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Littérature scientifique sur le sujet « Cortical organoids »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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Articles de revues sur le sujet "Cortical organoids"

Bao, Zhongyuan, Kaiheng Fang, Zong Miao, et al. "Human Cerebral Organoid Implantation Alleviated the Neurological Deficits of Traumatic Brain Injury in Mice." Oxidative Medicine and Cellular Longevity 2021 (November 22, 2021): 1–16. http://dx.doi.org/10.1155/2021/6338722.

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Traumatic brain injury (TBI) causes a high rate of mortality and disability, and its treatment is still limited. Loss of neurons in damaged area is hardly rescued by relative molecular therapies. Based on its disease characteristics, we transplanted human embryonic stem cell- (hESC-) derived cerebral organoids in the brain lesions of controlled cortical impact- (CCI-) modeled severe combined immunodeficient (SCID) mice. Grafted organoids survived and differentiated in CCI-induced lesion pools in mouse cortical tissue. Implanted cerebral organoids differentiated into various types of neuronal c

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Camp, J. Gray, Farhath Badsha, Marta Florio, et al. "Human cerebral organoids recapitulate gene expression programs of fetal neocortex development." Proceedings of the National Academy of Sciences 112, no. 51 (2015): 15672–77. http://dx.doi.org/10.1073/pnas.1520760112.

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Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the extent to which in vitro organoid systems recapitulate neural progenitor cell proliferation and neuronal differentiation programs observed in vivo remains unclear. Here we use single-cell RNA sequencing (scRNA-seq) to dissect and compare cell composition and progenitor-to-neuron lineage relationships in human cerebral organoids and fetal neocortex. Covariation network analysis using the fetal neocortex data reveals known and previously u

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Handcock, Sarah, Kay Richards, Timothy J. Karle, et al. "Three-Dimensional Morphological Characterisation of Human Cortical Organoids Using a Customised Image Analysis Workflow." Organoids 4, no. 1 (2025): 1. https://doi.org/10.3390/organoids4010001.

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Summary Statement: A tailored image analysis workflow was applied to quantify cortical organoid health, development, morphology and cellular composition over time. The assessment of cellular composition and viability of stem cell-derived organoid models is a complex but essential approach to understanding the mechanisms of human development and disease. Aim: Our study was motivated by the need for an image-analysis workflow, including high-cell content, high-throughput methods, to measure the architectural features of developing organoids. We assessed stem cell-derived cortical organoids at 4

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Yang, Woo Sub, Ferdi Ridvan Kiral, and In-Hyun Park. "Telencephalic organoids as model systems to study cortical development and diseases." Organoid 4 (January 25, 2024): e1. http://dx.doi.org/10.51335/organoid.2024.4.e1.

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The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete. Recently, 3-dimensional brain models, known as brain organoids, have attracted considerable attention in modern neurobiological research. Brain organoids have been proven to be valuable for studying the neurodevelopmental principles and pathophysiology of the brain, as well as for developing potential therapeutics. Brain organoids can change the paradigm of

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Revah, Omer, Felicity Gore, Kevin W. Kelley, et al. "Maturation and circuit integration of transplanted human cortical organoids." Nature 610, no. 7931 (2022): 319–26. http://dx.doi.org/10.1038/s41586-022-05277-w.

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AbstractSelf-organizing neural organoids represent a promising in vitro platform with which to model human development and disease1–5. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrate into sensory and motivation-related circuits. MRI reveals post-transplantation organoid growth across multiple stem cell lines and an

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Farcy, Sarah, Alexandra Albert, Pierre Gressens, Alexandre D. Baffet, and Vincent El Ghouzzi. "Cortical Organoids to Model Microcephaly." Cells 11, no. 14 (2022): 2135. http://dx.doi.org/10.3390/cells11142135.

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How the brain develops and achieves its final size is a fascinating issue that questions cortical evolution across species and man’s place in the animal kingdom. Although animal models have so far been highly valuable in understanding the key steps of cortical development, many human specificities call for appropriate models. In particular, microcephaly, a neurodevelopmental disorder that is characterized by a smaller head circumference has been challenging to model in mice, which often do not fully recapitulate the human phenotype. The relatively recent development of brain organoid technolog

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Bray, Natasha. "Inroads into cortical organoids." Nature Reviews Neuroscience 20, no. 12 (2019): 717. http://dx.doi.org/10.1038/s41583-019-0237-y.

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Conforti, P., D. Besusso, V. D. Bocchi, et al. "Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes." Proceedings of the National Academy of Sciences 115, no. 4 (2018): E762—E771. http://dx.doi.org/10.1073/pnas.1715865115.

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Increasing evidence suggests that early neurodevelopmental defects in Huntington’s disease (HD) patients could contribute to the later adult neurodegenerative phenotype. Here, by using HD-derived induced pluripotent stem cell lines, we report that early telencephalic induction and late neural identity are affected in cortical and striatal populations. We show that a large CAG expansion causes complete failure of the neuro-ectodermal acquisition, while cells carrying shorter CAGs repeats show gross abnormalities in neural rosette formation as well as disrupted cytoarchitecture in cortical organ

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Chandrasegaran, Praveena, Agatha Nabilla Lestari, Matthew C. Sinton, Jay Gopalakrishnan, and Juan F. Quintana. "Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids." F1000Research 12 (July 28, 2023): 437. http://dx.doi.org/10.12688/f1000research.131507.2.

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Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder. Sleeping sickness is traditionally studied using murine models of infection due to the lack of alternative in vitro systems that fully recapitulate the cellular diversity and functionality of the human brain. The aim of this study is to develop a much-needed in vitro system that reduces and replaces live animals for the study of infections in t

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Li, Xiaodong, Abdullah Shopit, and Jingmin Wang. "A Comprehensive Update of Cerebral Organoids between Applications and Challenges." Oxidative Medicine and Cellular Longevity 2022 (December 5, 2022): 1–10. http://dx.doi.org/10.1155/2022/7264649.

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The basic technology of stem cells has been developed and created organoids, which have established a strong interest in regenerative medicine. Different cell types have been used to generate cerebral organoids, which include interneurons and oligodendrocytes (OLs). OLs are fundamental for brain development. Abundant studies have displayed that brain organoids can recapitulate fundamental and vital features of the human brain, such as cellular regulation and distribution, neuronal networks, electrical activities, and physiological structure. The organoids contain essential ventral brain domain

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Thèses sur le sujet "Cortical organoids"

Pigeon, Julien. "The role of NEUROG2 T149 phosphorylation site in the developing human neocortex." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS092.

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Le développement des fonctions cognitives supérieures observée au cours de l'évolution des mammifères, repose sur la capacité des progéniteurs corticaux à augmenter leur production neuronale et ainsi étendre la surface du neocortex. Chez les mammifères dit gyrencéphaliques, où la période de production neuronale est allongée, la régulation du type de division, proliférative ou neurogénique, des progéniteurs corticaux est d'autant plus importante pour garantir l'accumulation de neurones. Dans le télencéphale dorsal, à l'origine du néocortex, c'est l'articulation de la voie de signalisation Notch

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Buchsbaum, Isabel Yasmin [Verfasser], and Silvia [Akademischer Betreuer] Cappello. "Discovering novel mechanisms of human cortical development & disease using in vivo mouse model and in vitro human-derived cerebral organoids / Isabel Yasmin Buchsbaum ; Betreuer: Silvia Cappello." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1215499760/34.

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RIZZUTI, LUDOVICO. "PATIENT-SPECIFIC MODELLING OF SYNDROMIC AUTISM: UNCOVERING THE ROLE OF ADNP IN CHROMATIN DYSREGULATION." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/907414.

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ADNP encodes Activity-Dependent Neuroprotective Protein, whose de novo heterozygous mutations cause Helsmoortel-Van der Aa Syndrome (HVDAS), a rare developmental syndrome affecting brain formation and neuronal functions, involving autism spectrum disorder and intellectual disability. Although ADNP is one of the single-gene most frequently mutated in ASD, its precise role in the syndrome onset has yet to be clarified. ADNP is the DNA-binding component of the newly identified chromatin remodeler complex ChAHP in mESC. It recognizes euchromatin regions to establish less accessible local chromatin

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Samaroo, Dominic. "Spatacsin in neurodevelopment : critical for lysosomal calcium & cortical progenitor function." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS212.

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La paraplégique spastique héréditaire de type 11 (SPG11) est un trouble neurogénétique rare caractérisé par une faiblesse progressive et une spasticité des membres inférieurs, et souvent par une déficience intellectuelle dès l'enfance. SPG11 est causée par des mutations de type perte de fonction dans le gène SPG11 qui code la protéine spatacsine. Quoique traditionnellement considérée comme une maladie neurodégénérative, des découvertes récentes suggèrent que SPG11 a également une composante neurodéveloppementale qui pourrait contribuer à l'étiologie de la maladie. Bien que le rôle subcellulair

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Guyomar, Tristan. "Roles of acto-myosin cortex dynamics in organoid self-organisation." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ100.

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Dans cette thèse, nous étudions les organoïdes, mini-organes auto-assemblés issus de quelques cellules souches, qui offrent une perspective unique pour étudier l'organogenèse. Notre recherche relie les formes et les mouvements collectifs des organoïdes à la dynamique hors équilibre du cortex d’acto-myosine. À l'interface entre la physique et la biologie, nous concevons des expériences pour quantifier les propriétés cellulaires et tissulaires et nous intégrons ces mesures dans des modèles physiques révélant les règles d’auto-organisation des organoïdes. En utilisant des cystes MDCK, un modèle o

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SKAROS, ADRIANOS. "CEREBRAL CORTICAL GENERIC CIRCUITS SELECTED IN ANATOMICALLY MODERN HUMAN EVOLUTION: A DISSECTION VIA ORTHOGONAL CRISPR PERTURBATIONS." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/945932.

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Anatomically modern humans (AMHs) have evolved neural features that differ significantly from those of archaic hominins and underlie their cognitive-behavioural specificities; their evolution, however, has thus far been predominantly inferred from the fossil record and from the comparison of modern and archaic genomes. In doing so, a vast number of genes have been found to harbour changes within protein-coding regions, rendering these different between the AMH genome and Neanderthal and Denisovan genomes. To investigate the functional importance of amino acid changes in the modern human cortex

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Kanton, Sabina. "Dissecting human cortical development evolution and malformation using organoids and single-cell transcriptomics." 2019. https://ul.qucosa.de/id/qucosa%3A71686.

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During the last years, important progress has been made in modeling early brain development using 3-dimensional in vitro systems, so-called cerebral organoids. These can be grown from pluripotent stem cells of different species such as our closest living relatives, the chimpanzees and from patients carrying disease mutations that affect brain development. This offers the possibility to study uniquely human features of brain development as well as to identify gene networks altered in neurological diseases. Profiling the transcriptional landscape of cells provides insights into how gene expressi

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Chapitres de livres sur le sujet "Cortical organoids"

Schütze, Theresa M., Nora Bölicke, Katrin Sameith, and Mareike Albert. "Profiling Cell Type-Specific Gene Regulatory Regions in Human Cortical Organoids." In Neuromethods. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2720-4_2.

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Suzuki, Ikuro. "Toxicological Assessment of Drugs Based on Electrical Activities of Human iPSC-Derived Cortical Neurons, Sensory Neurons and Cerebral Organoids." In Current Human Cell Research and Applications. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-4256-1_4.

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Uzoechi, Samuel, Balgees Khader, Shannon Byrrne, et al. "Cortical-Organoid Grafted Microvascular Bed on a Chip." In Neuromethods. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3999-3_19.

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Varela, Maria C., Ranmal Samarasinghe, and Jack M. Parent. "Functional Exploration of Epilepsy Genes in Patient-Derived Cells." In Jasper's Basic Mechanisms of the Epilepsies, 5th ed., edited by Jeffrey L. Noebels. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197549469.003.0042.

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Abstract Advances in human induced pluripotent stem cell (iPSC) approaches have greatly expanded the use of patient-derived cellular models, including cortical-like neurons and brain organoids, to study genetic epilepsies. New protocols to differentiate iPSCs into various neural cell types, and to generate brain region-specific organoids, have accelerated progress. In addition, the application of gene editing techniques adds rigor to these studies and offers the opportunity to model rare genetic epilepsies by enabling correction or insertion of mutations to generate isogenic controls or virtua

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Ribierre, Théo, and Stéphanie Baulac. "Brain Mosaicism in Epileptogenic Cortical Malformations." In Jasper's Basic Mechanisms of the Epilepsies, 5th ed., edited by Jeffrey L. Noebels. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197549469.003.0043.

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Abstract This chapter focuses on focal cortical dysplasia type II (FCDII) and mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE), a mild malformation of cortical development, for which genetic advances have been remarkable in recent years. There is now clear evidence that FCDII is caused by brain somatic mutations in genes belonging to the mTOR pathway, and that MOGHE, a mild malformation of cortical development, is due to somatic mutations in the SLC35A2 gene, encoding the major Golgi-localized UDP-galactose transporter. Numerous rodent models usin

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Kalpana, Kriti, Chandrika Rao, Stefan Semrau, Bin Zhang, Scott Noggle, and Valentina Fossati. "Generating Neuroimmune Assembloids Using Human Induced Pluripotent Stem Cell (iPSC)-Derived Cortical Organoids and Microglia." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/7651_2024_554.

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Actes de conférences sur le sujet "Cortical organoids"

Barton, Shawn, Alexia King, Anson Sing, Maureen Sampson, and Steven Sloan. "Elucidating Mechanism of Ammonia Toxicity Using Cortical Organoids (P5-7.001)." In 2023 Annual Meeting Abstracts. Lippincott Williams & Wilkins, 2023. http://dx.doi.org/10.1212/wnl.0000000000202187.

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Wilson, Madison N., Martin Thunemann, Francesca Puppo, et al. "Investigation of functional integration of cortical organoids transplanted in vivo towards future neural prosthetics applications." In 2023 11th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2023. http://dx.doi.org/10.1109/ner52421.2023.10123847.

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