Thèses sur le sujet « Conception de produits chimiques »
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Gallet, Sébastien. « Conception, synthèse et évaluation pharmacologique de thiadiazépines et oxathiazépines potentiellement anticancéreuses ». Lille 2, 2003. http://www.theses.fr/2003LIL2P002.
Texte intégralDiyani, Samira. « Elaboration d'un sel industriel : Le chlorure de potassium conception et mise au point d'un nouveau procédé de purification ». Mulhouse, 1997. http://www.theses.fr/1997MULH0480.
Texte intégralRivera, Gil Jose Luis. « A system approach to support a methodology for the design of formulated cosmetic products in the context of companies ». Electronic Thesis or Diss., Université de Lorraine, 2022. http://docnum.univ-lorraine.fr/ulprive/DDOC_T_2022_0268_RIVERA_GIL.pdf.
Texte intégralManaging a new chemical product design and development project is a complex task at different levels. In addition to the technical challenges of the formulation and the definition of process conditions, design teams should also consider the requirements of the organization where the product design is performed. Therefore, the organizational dimension and its importance in chemical product design are explored in this research. Through a bibliometric literature review, it was found that chemical product design methodologies integrating the organizational context have not been thoroughly analyzed and are highly required. In this research, through a systemic analysis based on information collected in semi-structured interviews with design experts of the cosmetic sector, the characteristics of the organizational context and its effects on the product design process of that sector were studied. Additionally, information captured during those interviews was formalized in an expert knowledge base of recommendations to support the cosmetic product design process. A tool to adapt those recommendations to the design process of specific companies was proposed. The tool is applied through collaborative workshops which enable the active participation of the design team in the evaluation of the design process in order to select and implement the most suitable recommendations. Finally, the tool is applied in a real organization showing how it can be used to evaluate and improve a real design process. In that case it was found that the tool proposes adapted improvement solutions aligned to the company's value concepts, where the design team has the role of evaluator and builder of its own design methodology
Mertens, Johann. « Conception d'un microlevier et analyse de sa réactivité avec un gaz : application à la réalisation d'un capteur de détection de florure d'hydrogène ». Dijon, 2003. http://www.theses.fr/2003DIJOS055.
Texte intégralThe objective of this work was the development of an hydrogen fluoride (HF) sensor by mechanical response of SiOx and Si3N4 microcantilevers that have typical dimensions of 2003́00́. 5 æm. Their fabrication uses thin films coating, lithography and reactive ion etching processes. A XPS, SIMS, AFM study of the dielectric layers shows a lateral etching orientation for SiOx and a transversal one for Si3N4. A gold layer (not reactive) is deposited on one face of the cantilever, making it sensitive to both temperature and surface stress. The sensitivity of the system to the temperature, pressure and humidity has been defined. SiOx and Si3N4 layers reactivity toward HF was measured in term of deflection and frequency resonance variation. The response of the sensor depends on the amount of HF introduced into the cell. The gas is then detected in term of irreversible deflection until 260 ppb. The influence of the surface roughness and stoichiometry of the reactive layers was demonstrated
Serna, Rodas Juliana. « Methodological approach for the sustainable design of structured chemical products during early design stages ». Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0219.
Texte intégralEmulsion based chemical products, which belong to the category of micro-structured chemical products, have a broad range of commercial applications. Despite their importance, there is not a general methodology for their design. With the aim to contribute to the progress on this matter, this research presents a product design methodology focused on emulsion design with the following characteristics: it proposes methods for customer needs analysis, product ideas generation and selection of the best product alternative. It considers the multivariate nature of emulsion design by taking into account the multiple effects of design variables into product properties. It integrates sustainability concepts into the product design process. The methodology comprises three design stages: needs stage, ideas generation stage and ideas selection stage. In the needs stage, customer needs are first analyzed and classified according to their effect on customer satisfaction and second translated into product specifications with the aid of experts and customers. The input is customer needs, i.e., statements expressing customers’ desires about the product, and the output corresponds to product specifications, i.e., product characteristics that can be measured. To perform this stage two methods are used: Kano model and Quality Functional Deployment. In ideas generation stage, product concepts accomplishing product specifications are generated in three sub-steps: First, problem specifications are classified into a predefined group of design sub-problems. Second, each sub-problem is connected with one or more pre-defined solution strategies through a prefilled relational matrix. Third, compatible solution strategies are selected and connected to ingredients and processing conditions through a second relational matrix. As result, a set of product concepts is generated. Thisprocedure is developed by the implementation of two relational matrices proposed in this research based on emulsion science and expert knowledge. The first connects sub-problems with solution strategies and the second connects solution strategies with ingredients and processing conditions. In the selection stage, generated product concepts are evaluated according to product specifications. In addition, appropriated sustainability indicators are included to assess and rank product alternatives according to a global sustainability index. To perform this stage, a set of indicators are selected and integrated by the implementation of multi-criteria analysis methods. The application of the methodology is exposed with a case study: the design of a moisturizing cream
Tomazeli, Duarte Leonardo. « Conception de réseaux de capteurs chimiques intelligents : une approche fondée sur les méthodes de séparation de sources ». Grenoble INPG, 2009. http://www.theses.fr/2009INPG0085.
Texte intégralLn this thesis, we study the problem of quantitative chemical analysis through sensor arrays. However, unlike the majority of the works in this line, we consider an unsupervised approach in which the adjustment of the signal processing method does not require a set of training (or calibration) points. This situation can be formulated as a Blind Source Separation (BSS) problem. The difficulty here lies in the fact that the chemical sensors considered in this research are dearly nonlinear devices, thus resulting in nonlinear mixing models. The main contributions of this research are related to the development of nonlinear BSS methods tailor-made for arrays of ion-selective electrodes. We consider a paradigm based upon the Independent Component Analysis but also upon other strategies that allow us to incorporate some information typical of the application considered in this research, like positivity of chemical activities
Zimmermann, Céline. « Conception, réalisation et étude de micro-capteurs à ondes de Love pour applications en milieu gazeux : Cas de la détection de composés organophosphorés ». Bordeaux 1, 2002. http://www.theses.fr/2002BOR12471.
Texte intégralBruniaux, Sophie. « Nouveaux hydrotropes biosourcés : conception, synthèse et propriétés physico-chimiques en milieu hautement salin ». Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2378.
Texte intégralHistorically, chemical industry was based on fossil ressources, but alternative processes have been developed since the nineteens to be green and to answer to the environmental eco-responsibility questions. In this context, a collaboration work between three public laboratories and the SAS PIVERT emerged to find new biosourced hydrotropes starting from various polyols – such as glycerol, main byproduct of the fuel production – and resistant to high saline conditions. A specific design was defined by our physico-chemical partner for the synthesis of hydrotropes. Differents approaches were used to obtain these compounds, such as a new method of methylation using sub/supercritical methanol with a phase of optimization, and another about the scope of the reaction that reduced the reaction steps. The transposition of the reductive alkylation of various alcohols was also realized – using a heterogeneous catalysis – with the obtention of various ethers, in continuous flow conditions, by the intermediate of the use of the HCube Pro from ThalesNano
Perez, Marc. « Conception, hémisynthèse et évaluation biologique de composés à visée antitumorale à partir de produits naturels ». Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066760.
Texte intégralThis manuscript reports the semisynthesis of anticancer compounds starting from securinine, an alkaloid found in the shrub Securinega suffruticosa. A set of compounds was obtained by cleavage and functionnalization of the scaffold of securinine. 1,6-addition reaction have been developed to afford further analogues. Palladium-catalyzed cross coupling reactions such as Heck, Sonogashira and Suzuki couplings have been used for the synthesis of new C14 or C15 substituted securinine derivatives. The anticancer properties of these derivatives were assayed against four cancer cell lines and were used to define the structure-activity relationship of securinine. Noteworthy, potent cytotoxic derivatives displaying an IC50 of 60 nM have been obtained
Lemagnen, Maud. « Intégration du risque chimique dans la conception de produits industriels. Application au secteur de l'aéronautique ». Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00587357.
Texte intégralSerna, Rodas Juliana. « Methodological approach for the sustainable design of structured chemical products during early design stages ». Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0219.
Texte intégralEmulsion based chemical products, which belong to the category of micro-structured chemical products, have a broad range of commercial applications. Despite their importance, there is not a general methodology for their design. With the aim to contribute to the progress on this matter, this research presents a product design methodology focused on emulsion design with the following characteristics: it proposes methods for customer needs analysis, product ideas generation and selection of the best product alternative. It considers the multivariate nature of emulsion design by taking into account the multiple effects of design variables into product properties. It integrates sustainability concepts into the product design process. The methodology comprises three design stages: needs stage, ideas generation stage and ideas selection stage. In the needs stage, customer needs are first analyzed and classified according to their effect on customer satisfaction and second translated into product specifications with the aid of experts and customers. The input is customer needs, i.e., statements expressing customers’ desires about the product, and the output corresponds to product specifications, i.e., product characteristics that can be measured. To perform this stage two methods are used: Kano model and Quality Functional Deployment. In ideas generation stage, product concepts accomplishing product specifications are generated in three sub-steps: First, problem specifications are classified into a predefined group of design sub-problems. Second, each sub-problem is connected with one or more pre-defined solution strategies through a prefilled relational matrix. Third, compatible solution strategies are selected and connected to ingredients and processing conditions through a second relational matrix. As result, a set of product concepts is generated. Thisprocedure is developed by the implementation of two relational matrices proposed in this research based on emulsion science and expert knowledge. The first connects sub-problems with solution strategies and the second connects solution strategies with ingredients and processing conditions. In the selection stage, generated product concepts are evaluated according to product specifications. In addition, appropriated sustainability indicators are included to assess and rank product alternatives according to a global sustainability index. To perform this stage, a set of indicators are selected and integrated by the implementation of multi-criteria analysis methods. The application of the methodology is exposed with a case study: the design of a moisturizing cream
Blanc, Claire-Line. « Conception et optimisation d’un procédé innovant pour la purification d’acides organiques issus de biotechnologie ». Thesis, Châtenay-Malabry, Ecole centrale de Paris, 2015. http://www.theses.fr/2015ECAP0008.
Texte intégralThe objective of this study is to evaluate the use of preparative chromatography in the context of the elaboration and optimization of an innovative purification process of organic acids from biotechnology. Lactic and succinic acids were mainly studied. They are produced by fermentation and used in industry as additive, for a long time. They are identified as promising building blocks for green chemistry development, from renewable carbon. In particular, they are monomers for bioplastic industry. Unlike historical utilizations, this new type of application requires much higher purity levels. Those purities are currently obtained by additional purification steps, like liquid-liquid extraction, distillation and/or crystallization. We tried to evaluate if the required specifications may be reached by the implementation of preparative chromatography. For this chromatography was studied in details as unitary operation, in order to better understand separation mechanisms of studied compounds and implementation parameters. Two resin types were mainly used, a strong cationic one and a strong anionic one. Firstly, thermodynamic study of the adsorption of three organic acids in pure solution was performed. It revealed very different performances for both resins: adsorption on strong cationic resin is quite linear, whereas on strong anionic one adsorption is strongly nonlinear and fits with Langmuir model. Elution velocity influence on peak shape and so on dispersion was then studied. Column efficiency decreases linearly with elution velocity, accordingly to Van Deemter model. It was shown that the line slope was identical at lab scale and on a pilot ten times bigger. Then it may be used to predict column efficiency evolution during scale-up. Mixing solutions from synthetic or real origin were studied, to evaluate operational parameter influence on the separation, as load, feed concentration, pH… On the strong anionic resin, a first modeling was developed for experimental results. It highlighted that Langmuir type adsorption mechanism is not able to explain peak shape and position. We supposed that an ion exchange mechanism with the organic acid dissociated part may happen. This exchange may have a significant impact on peak shape and position, even if organic acids are mainly in molecular form, because of a low work pH. 4 Separations established at lab scale were validated at pilot scale in continuous chromatography ISMB. It was demonstrated that the anionic resin allows to reach a higher productivity than the cationic one, with a similar productivity. A complete purification process was tested with succinic acid, using bipolar electrodialysis acidification, reverse osmosis concentration, preparative chromatography separation with a strong anionic resin and nanofiltration discoloration. Product was then crystallized, to be compared to an industrial product. Our crystals were close to waited specifications and relatively better than the industrial ones. An additional ion exchange step could have allows to reach polymer grade. We show that chromatography is useful in an organic acid purification process, in order to reach a very high purity
Fathallah, Houssem Eddine. « Conception d'un système temps-réel de surveillance de l'exposition aux polluants de l'air intérieur : application au formaldéhyde ». Electronic Thesis or Diss., Université de Lorraine, 2016. http://www.theses.fr/2016LORR0100.
Texte intégralFormaldehyde is classified as a "high priority" pollutant in the indoor air quality. Because of its health effects, the emerging French regulation (Action 7 of PNSE2) requires the measurement of formaldehyde in public places (schools, kindergartens etc.) from 2017. However, no device on the market is able to provide accurate measurements in real time and at low cost. This thesis forms part of the ANR project CAPFEIN (réseau de CAPteurs de FormaldEhyde intelligents pour la surveillance de l'air Intérieur) whose purpose is to develop a "smart Formaldehyde sensor". The thesis objective is to design a real-time monitoring system of human exposure to formaldehyde, and more generally to indoor air pollutant. The sensors must be equipped with a communication interface to automatically collect measurements at different points of the environment to be monitored. Two monitoring systems have been developed. The first is Designed with commercial off-the-shelf component and a centralized architecture based on the concept of the Internet of Things (IoT). The second was designed from the CRAN and corresponds to the development of a solution based on a distributed approach. A smart badge has been developed. It can monitor exposure levels to each cardholder. The major constraints of this work consist on the ability to locate people in an indoor environment and the ability to optimize the algorithms in terms of memory space and power consumption. For the optimization part, the moving average exponential weighting methods have been implemented and evaluated. Both prototypes were tested in buildings of CRAN and showed interest
Ruellan, Alexandre. « Conception raisonnée à l’aide de la formulation et du procédé d’un film souple biosourcé et biodégradable pour l’emballage alimentaire ». Electronic Thesis or Diss., Paris, AgroParisTech, 2015. http://www.theses.fr/2015AGPT0032.
Texte intégralThe use of renewable resources and the production of biodegradable materials are appropriate solutions to reduce the environmental impact of the sector of plastics. There is thus a demand for eco-friendly products on the market provided they obtain performance equal or superior to synthetic materials currently used. One possibility, widely used in the food sector, to achieve efficient packaging film is the creation of multilayer structures by combining advantageous properties of different plastics. In this case, recycling of materials is difficult and the biodegradability of the packaging becomes relevant. This study proposes designing biobased and biodegradable films for food packaging from polylactide and co- products of the oil mill industry as additives, in particular the deodorization condensates. Among these lasts, the partial solubility of their molecules and the synergetic effect of the liquid and solid fat components at room temperature, depending on their alkyl chain length and unsaturation ratio, have both been observed to be responsible for the ductility increase, while the higher than room temperature glass transition of PLA and its interesting rigidity were retained. Addition of PHBV to the formulated PLA with oil by-products has also been studied, mainly leading to a significant improvement in the thermomechanical resistance of the material. Scaled-up trials comprising the production of formulated pellets, cast extruded films and their printing using industrial devices were performed. Finally, with the help of the “Laboratoire National de Métrologie et d’Essais” (LNE), the compliance with requirements of Food Contact Material regulation of a formulated film of PLA, as well as its biodegradability according to the EN 13432 standard, have both been proved
Dandeu, Aurélie. « Maîtrise de la précipitation des polymorphes du carbonate de calcium en vue de la conception d’un procédé de purification en réacteur à lit fluidisé ». Thesis, Vandoeuvre-les-Nancy, INPL, 2006. http://www.theses.fr/2006INPL056N/document.
Texte intégralThe purification process of sodium chloride solutions consists of the precipitation of Ca2+ and Mg2+ ions as calcium carbonate and magnesium hydroxide. The impurity content is low, so the best results can be obtained when the precipitation takes place in a fluidized bed reactor where the solid concentration is high. The improvement of the precipitate quality, mainly composed of CaCO3, is necessary for the good running of the process, thus the control of the calcium carbonate polymorphism is essential. First, a reliable method for the quantitative determination of the polymorphic composition using Raman spectroscopy combined with multivariate curve resolution is developed. Then the key parameters which control the polymorphic. composition are identified through the experiments carried out in a batch reactor. Based on these results, a new process using a fluidized bed reactor is designed and experimentally tested. From these experiments, the optimal operating conditions allowing a high level of purification and a very good solid/liquid separation are determined
Fathallah, Houssem Eddine. « Conception d'un système temps-réel de surveillance de l'exposition aux polluants de l'air intérieur : application au formaldéhyde ». Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0100.
Texte intégralFormaldehyde is classified as a "high priority" pollutant in the indoor air quality. Because of its health effects, the emerging French regulation (Action 7 of PNSE2) requires the measurement of formaldehyde in public places (schools, kindergartens etc.) from 2017. However, no device on the market is able to provide accurate measurements in real time and at low cost. This thesis forms part of the ANR project CAPFEIN (réseau de CAPteurs de FormaldEhyde intelligents pour la surveillance de l'air Intérieur) whose purpose is to develop a "smart Formaldehyde sensor". The thesis objective is to design a real-time monitoring system of human exposure to formaldehyde, and more generally to indoor air pollutant. The sensors must be equipped with a communication interface to automatically collect measurements at different points of the environment to be monitored. Two monitoring systems have been developed. The first is Designed with commercial off-the-shelf component and a centralized architecture based on the concept of the Internet of Things (IoT). The second was designed from the CRAN and corresponds to the development of a solution based on a distributed approach. A smart badge has been developed. It can monitor exposure levels to each cardholder. The major constraints of this work consist on the ability to locate people in an indoor environment and the ability to optimize the algorithms in terms of memory space and power consumption. For the optimization part, the moving average exponential weighting methods have been implemented and evaluated. Both prototypes were tested in buildings of CRAN and showed interest
Rocklin, Pascal. « Conception de sondes de détection et développement de techniques de mesure in situ de la contamination de matrices solides (sols, déchets) par des composés organiques volatils ». Vandoeuvre-les-Nancy, INPL, 1996. http://www.theses.fr/1996INPL049N.
Texte intégralHaicour, Philippe. « La brevetabilité des produits chimiques ». Paris 2, 1992. http://www.theses.fr/1992PA020103.
Texte intégralA french patent directly protects chemicals as products and indirectly as results of manufacture processes or as applications means. That is ordinary and straight follows from the law of 1944. Since, chemistry highly advanced and mainly in the scope of molecular structures which were ignored by former science, technics and of course, industrial property rights. As former law, new ones such as this of 1968 and the epc are well fifted to the protection of material objets physically at human scale. Their provisions no more harmonize with protection of infinitesimal molecules than they do with new objets the industry uses today, such as new plant varieties, computer programs or integrated circuits. Moreover, the material tools, the law protects as inventions, are intented to definite uses apparent through their forms. In return, the same molecule may be used in various applications without any physical alteration in its presentatio. Regulations have yet taken in account such features. The patent law often interferes with it and will no longer be mended with dissimilar provisions as those relating to medecines, or the second therapeutical or non therapeutical applications or, may be soon, to biochemically modified plants and animals
Brass, Olivier. « Interactions physico-chimiques des produits de. . » Lyon 1, 1992. http://www.theses.fr/1992LYO1T257.
Texte intégralAvrillon, Yvan. « Traitements chimiques de l'hyperesthésie dentinaire ». Nantes, 1999. http://www.theses.fr/1999NANT008D.
Texte intégralRasoulifar, Golnoosh. « Conception intégrée de produits de marque ». Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENI020/document.
Texte intégralDesign of branded products involves consideration of both perceptual aspects of the product appearance (related to consumers’ evaluation and emotions and the brand values) as well as the technical and engineering aspects including manufacturing feasibility, performances, and cost. Within a multidisciplinary design context, product designers and engineering designers need to collaborate and communicate together to achieve a satisfactory product that is emotionally appealing to the consumers and is technically performing the intended functions, and is feasible to manufacture. However, such collaboration between product designers and engineering designers is difficult due to their different knowledge background, work approaches and responsibilities during the design process. This research deals with the questions of how to support the communication between product designers and engineering designers and how to support the integration of the engineering viewpoint earlier in the design process of branded product. Proposition and evaluation of three potential approaches to support communication between product designers and engineering designers is investigated in this research. Likewise an integration approach is proposed following the three steps of modeling, transforming and integrating the engineering knowledge to design knowledge. The results of this research contribute to the SKIPPI project, in the development of a software to support idea generation and the decision-making in the upstream design phase
Le, Coq Marc. « Approche integrative en conception de produits ». Paris, ENSAM, 1992. http://www.theses.fr/1992ENAM0037.
Texte intégralBois, Frédéric. « Modélisation mathématique de la cancérogenèse par des produits chimiques ». Metz, 1988. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/1988/Bois.Frederic.SMZ889.pdf.
Texte intégralA mathematical model of carcinogenesis is described for the case of vinyl chloride. The model includes a description of toxicokinetics, metabolism, cellular action of the compound. An assessment of the risk of cancer from drinking water contaminants is presented. For the risk estimates, confidence intervals have been obtained by Monte-Carlo simulations
Bois, Frédéric. « Modélisation mathématique de la cancérogenèse par des produits chimiques ». Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37612025d.
Texte intégralBois, Frédéric Vasseur Paule. « MODELISATION MATHEMATIQUE DE LA CANCEROGENESE PAR DES PRODUITS CHIMIQUES / ». [S.l.] : [s.n.], 1988. ftp://ftp.scd.univ-metz.fr/pub/Theses/1988/Bois.Frederic.SMZ889.pdf.
Texte intégralBenaissa, Wassila Gabas Nadine Cabassud Michel. « Développement d'une méthodologie pour la conduite en sécurité d'un réacteur continu intensifié ». Toulouse : INP Toulouse, 2008. http://ethesis.inp-toulouse.fr/archive/00000356.
Texte intégralCassier, Jean-Laurent. « Argumentation et conception collaborative de produits industriels ». Phd thesis, Grenoble INPG, 2010. http://tel.archives-ouvertes.fr/tel-00557483.
Texte intégralVERDOUCQ, ACHTE ISABELLE. « Etude epidemiologique de mortalite dans une usine de produits chimiques ». Lille 2, 1994. http://www.theses.fr/1994LIL2M167.
Texte intégralAlain, Eléonore. « Optimisation des paramètres chimiques du circuit primaire des centrales électronucléaires ». Paris 6, 1997. http://www.theses.fr/1997PA066772.
Texte intégralTitah-Benbouzid, Hosna. « Comportement physico-chimique des produits chimiques déversés accidentellement en milieu marin ». Phd thesis, Université de Bretagne occidentale - Brest, 2010. http://tel.archives-ouvertes.fr/tel-00744690.
Texte intégralGehin, Alexis. « Développement d’une méthodologie de conception de produits durables ». Grenoble INPG, 2007. http://www.theses.fr/2007INPG0190.
Texte intégralSustainable development obligate industrials to adopt a life cycle approach. The “principle of conservation” and the “extended producer responsibility” foster the development of closed-loop industrial systems, in which the product plays a central role. Products design adapted to these news systems is thus fundamental. In order to overcome the lack of methodologies in the early design phases for the evaluation of the environmental performance of the product and the benefits related to the component recovery strategies, we have developed a methodology for designing sustainable products. Based on simplified life cycle impact assessment and functional analysis, it aims at giving designers an additional design criteria for the decision process. Several propositions allow us to supply with a tool for simulating closed-loop lifecycles along with a product view supporting the products design
Maussang-Detaille, Nicolas. « Méthodologie de conception pour les systèmes produits-services ». Grenoble INPG, 2008. http://www.theses.fr/2008INPG0165.
Texte intégralThe paradigm of mass production and consumption based on the sale of physical products is considered because of strong competition and environmental impacts caused by this paradigm. To tackle these considerations, a service-based economy has emerged. The customer does not buy anymore a physical product, but pays for the use or for results provided by a system composed of products and services. Therefore, engineering designers must now reconsider the way they design these new systems and in particular physical objects involved in these systems. This doctoral thesis proposes a design methodology for structuring the development of these PSS from the design of the system to the detailed design of physical objects involved in the final solutions. Representations derived from the functional analysis and the establishment of operational scenarios enable the designers to describe the overall organization of the elements included into the system. This organisation is represented through the design buckles of the functional bloc diagram. Finally, the evaluation of the system from the design buckles enables engineering designers to link the parameters of physical objects and service units in order to assess that the whole system fulfil the performance expected by the customer
Drouet-Fleurizelle, Laurence Gillard. « Caractérisation physico-chimique des interfaces dans les multicouches polymères, à finalité peintures extérieures aéronautiques ». Toulouse 3, 1992. http://www.theses.fr/1992TOU30117.
Texte intégralKhemis, Serge. « Conception, développement et utilisation d'un appareillage pour l'étude des cinétiques d'évaporation des solvants de peintures ». Aix-Marseille 3, 1993. http://www.theses.fr/1993AIX30093.
Texte intégralJoussein, Emmanuel. « L'halloysite : origine de la variabilité des propriétés physico-chimiques ». Poitiers, 2004. http://www.theses.fr/2004POIT2343.
Texte intégralHalloysite clay minerals occur widely around the world, and are a major component of Andisols and soils derived from volcanic materials in wet tropical and subtropical regions. The structure and chemical composition of halloysite are similar to those of kaolinite but the unit layers in halloysite are separated by a monolayer of water molecules. However, halloysites present various characteristics toward their cation exchange capacity, potassium selectivity, hydration state, and intercalation properties. To better understand their physical chemical properties, reference and soil halloysites were used. The hydration state and the presence of charges are the key factor controlling the specific properties of halloysite. For the same sample, the intercalation of organic molecules or salts is favoured when the halloysite is hydrated. Their charge properties and K selectivity are influenced by the hydratation state. Many charged sites becomes innaccessible after dehydration. The presence of permanent charge due to heterovalent substitutions or to impurities was not evidenced in the studied samples. These permanent charges could be induce by structural defects due to defects in the distribution of protons
Hermelin, Damien. « Modélisation de dispositifs à ondes élastiques de surface en milieu contraint mécaniquement et applications ». Besançon, 2010. http://www.theses.fr/2010BESA2037.
Texte intégralThe manuscrit concerns the development of surface acoustic waves sensors for wireless monitoring of physical parameters dedicated to biomedical applications, and more specially for blood pressure monitoring. The work consists first in the development of a new physical modeling for surfac acoustic wave device submitted to inhomogeneous stress distribution. The model is detailed and used to optimise geometric size of a membrane-based pressure sensor. The study focuses on quartz based solution but can be applied to any piezoelectric material. This manuscript also presents the sensor construction. The application as sensor has been validated and compared with results obtained with the above evolve model. Comparisons between experimental and theoretical reveals a quite good agreement and allows to validate the model reliability and the efficiency of the proposed optimization, and the model had no equivalent until now. The developped model yields new computation tools which allows acurate and fast design acoustic wave devices sensors for measuring mechanical parameters as illustrated throughout the manuscript. The final application concerns blood pressure monitoring using an external use of the sensor
Claros, Salinas Maria Paz. « Contribution à l'ingénierie des exigences en conception de produits industriels ». Grenoble INPG, 2008. http://www.theses.fr/2008INPG0149.
Texte intégralLn order to satisfy the constraints on competiveness and globalisation, the industrial organisations became very complex. The engineering design process shifted from a sequential process to a concurrent engineering and integrated design. Additionally, products being designed had made more complex the design process because multiple technologies (mechanical, software. . . ) are used while designing. Ln such context, the requirement management and the requirement engineering became complex tasks to achieve during the design process. We showed that the problem is not addressed from the beginning of the design process but that there is coevolution between problem and solution. To answer this challenge on requirement engineering, we first addressed activities that support requirements expression and evolution ail over the design process. Four activities were chosen. The next step was to look for means used in industrial organisations to support these activities (we focussed on elicitation and formalisation activities). Finally we proposed two models. The first one, underline the complexity of deploying requirements ina design process, and the second one highlights the relations between four elements of the organisation and their impact on the requirements network formalisation
Romestant, Damien. « Le commerce international des matériels et produits sensibles ». Montpellier 1, 2002. http://www.theses.fr/2002MON10070.
Texte intégralGoulet, Lise 1953. « Association entre la mortinatalite et lexposition aux produits chimiques pendant la grossesse ». Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75883.
Texte intégralA case control study was conducted among women working in three sectors: Health, Personal services and Agriculture, and Manufacturing industries. Two hundred and twenty-seven (227) stillbirths aged 20 weeks of gestation or more, were matched to two hundred and twenty-seven (227) livebirths, for mother's age, gravidity and socio-economic status. Chemicals were divided into ten (10) groups. Exposure was assessed by visits to the workplaces, telephone calls or extrapolations. Conditional logistic regression analyses were done.
Women working as hairdressers-beauticians$ sp+$ (O.R. 0,01 (0,00-0,34)) and those working in the garment industry* (O.R. 0,24 (0,08-0,77)) had significantly less stillbirths while women working in metal-electrical-chemical industries* (O.R. 5,11 (0,99-26,37)) had a significant excess of stillbirth. Exposure to pesticides/germicides, irrespective of the level or frequency$ sp+$ (O.R. 2,06 (1,15-3,68)), and occasional exposure to "miscellaneous" chemicals (other chemicals potentially fetotoxic)* (O.R. 12,07 (1,22-119,9)) showed a significant increased risk of stillbirth while exposure to a low level of metals$ sp+$ (O.R. 0,28(0,10-0,83)) showed a significantly lower risk of stillbirth.
Leatherworkers* (O.R. 2,59 (0,47-14,33)), women working in the textile industry$ sp+$ (O.R. 2,55 (0,42-15,41)), agricultural workers* (O.R. 3,88 (0,47-31,88)), women exposed to a moderate (2) level of metals$ sp+$ (O.R. 2,32 (0,59-9,10)) and those exposed to a high (3) level of solvents$ sp+$ (O.R. 2,49 (0,47-13,30)) had a non significant (P $>$ 0,05) increased risk of stillbirth.
The author proposes that ergonomic factors could be a confounder of the association between stillbirth and exposure to pesticides/germicides or metals. A study looking more closely at the association between stillbirth and ergonomic factors is therefore suggested. Because exposure of pregnant workers to elevated levels of chemicals is quite rare, further epidemiological studies should include more subjects. ftn$ sp+$: stillbirths aged 20 weeks of gestation or more. ftn*: stillbirths aged 28 weeks of gestation or more.
Bonhoure, Patrick. « Typologie de produits pour une prise en compte de la culture en conception de produits ». Compiègne, 2004. http://www.theses.fr/2004COMP1494.
Texte intégralLopez-Ontiveros, Miguel Angel. « Intégration des contraintes de remanufacturabilité en conception de produits ». Grenoble INPG, 2004. http://www.theses.fr/2004INPG0047.
Texte intégralThe mass of products in end of life becomes a real problem for the environment. Thus, industrials carry their attention on the product end of life strategies. The remanufacturing is an end of life strategy that reduces the use of raw materials and saves energy while preserving the value added during the design and manufacturing processes. But, in most of the cases, remanufacturing processes must be adapted to existing products because products have not been designed to be remanufacturable. The aim of our research was to propose an approach for the designers to integrate remanufacturing constraints during the design process. The purpose of this study was to identify product profiles based on design criteria to structure rules and indicators that designers will use during the conceptual design phase. For the products profiles definition 8 categories of design criteria were identified based on a survey of about thirty products successfully remanufactured. Then, we have developed the tool REPROø (REmanufacturig with PROducts PROfiles) that should lead to a real integrated design of remanufacturable products. Indeed, with this tool, designers at the beginning of their design project can use products profiles. It gives specific information to improve the internal technical definition of the product under study from a remanufacturing point of view
Benaissa, Wassila. « Développement d'une méthodologie pour la conduite en sécurité d'un réacteur continu intensifié ». Phd thesis, Toulouse, INPT, 2006. http://oatao.univ-toulouse.fr/7500/1/benaissa.pdf.
Texte intégralBenaissa, Wassila. « Développement d'une méthodologie pour la conduite en sécurité d'un réacteur continu intensifié ». Phd thesis, Toulouse, INPT, 2006. https://hal.science/tel-04576129.
Texte intégralThe aim of this study is to develop a methodology in order to carry out safely an exothermic reaction in an intensified continuous reactor. It is established on a case study: the transposition of the esterification between propionic anhydride and 2-butanol in a new prototype of heatexchanger/reactor. The approach is divided in three steps. In a first part, experimental data obtained by calorimetry allow to determine the potential hazard of the compounds as well as the reaction and a kinetic model is validated. In a second stage a dedicated software model is used to calculate optimal operating conditions for safe control. Experiments are then achieved to test these conditions. In the last step, the inherently safer behaviour of the reactor is evaluated in the case of probable malfunctions (fluids shutdown) due to the thermal inertia of the apparatus. Finally, the evolution of the temperature profiles is obtained by dynamic simulation
Hayat, Aktar. « Biocapteurs pour la détection de deux biotoxines : l'acide okadaique et l'ochratoxine A ». Perpignan, 2012. http://www.theses.fr/2012PERP1110.
Texte intégralThis work was focused on the development of new bioanalytical methods, exploring different bioreceptors, immobilization techniques and transduction methods, for the detection of okadaic acid (OA) and ochratoxin A (OTA) in food samples. The first part was based on the development of colorimetric assays by exploiting the inhibitory effect of the OA on protein phosphatase 2A (PP2A). PP2A purchased from GTP Technology, ZEU Immunotec and Millipore was entrapped within several membranes: photopolymers, sol-gel and agarose gels. These different immobilization techniques were tested, optimized and compared to detect OA. The second part was focused on the development of colorimetric and electrochemical immunoassays for OA detection. Enzyme-linked indirect competitive immunoassays based on OA immobilization via MBs and diazonium chemistry were developed both in batch and automated flow mode. To avoid the complexity involved in labeling of biomolecules, label-free detection techniques based on antibody immobilization via physical adsorption, protein-G-Mbs and covalent attachment were also investigated to detect OA. In the third part, the development of aptasensors for the detection of OTA was carried out. The aptasensor were based on MBs and click chemistry to perform the labeled and non-labeled electrochemical detection
Blondin, Catherine. « Polysaccharides sulfatés extraits d'algues brunes : activité anticomplémentaire des fucanes ». Paris 13, 1992. http://www.theses.fr/1992PA132041.
Texte intégralDrevelle, Christophe Delobel René Duquesne Sophie Le Bras Michel. « Étude de la dégradation de films à base de résine acrylique utilisée dans l'industrie textile ». [S.l.] : [s.n.], 2002. http://www.univ-lille1.fr/bustl-grisemine/pdf/memoires/F2002-153.pdf.
Texte intégralSur la p. de titre : DEA-Structure et dynamique des systèmes réactifs, PERF-Procédés d'élaboration de revêtements fonctionnels. Bibliogr. f. : 21-22. Annexes.
Lefaux, Sandra Tremblin Gérard. « Biodégradation de films polymères à usage agricole caractérisation physico-chimique des résidus et identification biomoléculaire des bactéries actives / ». [S.l.] : [s.n.], 2005. http://cyberdoc.univ-lemans.fr/theses/2005/2005LEMA1011.pdf.
Texte intégralSavary, Saôde. « État de la gestion environnementale dans les PME de produits chimiques au Québec ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0016/MQ56968.pdf.
Texte intégralGuldemann, Joan. « Evaluation du potentiel de sensibilisation de produits chimiques en fonction de leur réactivité ». Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF052.
Texte intégralContact dermatitis is one of the most common health problems and is highly prevalent in industrialized countries. Currently, only the total eviction of the allergen can prevent further allergic reactions. Since several years, different tests have been developed to determine the sensitization potential of a large number of compounds. Some of them are based on animal models. However, the cosmetic legislation now bans this kind of tests. In this context, the development of integrated strategies based on in silico, in chemico and on in vitro assays seems to be necessary. The aim of this PhD work is to compare reactivity data from in chemico tests realized at the laboratory, with biological data obtained from in vitro tests concerning the activation of the Keap1/Nrf2/ARE pathway in THP-1 and MoDCs dendritic cells (INSERM UMR-996). The reactivity of 10 compounds known for their implication in allergic contact dermatitis has been studied to show if a correlation exists between the potential of sensitization of allergens and the oxidative stress inducing dendritic cells maturation
Millet, Mélanie. « Composition et mécanismes de formation des troubles physico-chimiques dans les produits cidricoles ». Thesis, Rennes, Agrocampus Ouest, 2018. http://www.theses.fr/2018NSARB311/document.
Texte intégralPhysico-chemical haze appearance during storage of clarified apple-based beverages is a concern for producers. These hazes are caused by interactions between several constituents of the beverage that lead to the formation of visible aggregates. This work had two main goals: analyze the composition of hazes in order to determine which families of compounds are responsible for their formation, and understand which mechanisms are involved. First, the composition of the haze gathered from three apple-based beverages (cider, apple juice and pommeau) was analyzed. The results revealed the implication of phenolic compounds and led to the hypothesis that their oxidation was probably one of the main factors responsible for haze formation. Proteins were found in quite large quantities in some apple juice hazes, which suggests their involvement in haze formation in this beverage.These two hypotheses have been verified using two model approaches: in a model pommeau and in a model apple juice. This work evidenced that different kinds of hazes exist in apple-based beverages. On the one hand, haze in pommeaux and ciders is mainly explained by procyanidin oligomers self-aggregation induced by their oxidation, with possible interactions with other beverage constituents. On the other hand, haze in some apple juices, which probably contain low polyphenol and high protein levels, is triggered by “Pathogenesis-Related Proteins” denaturation that lead to their self-aggregation, in interaction with oligomeric procyanidins