Littérature scientifique sur le sujet « Composés biarylés »
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Articles de revues sur le sujet "Composés biarylés"
Nguyen, Thien. « Impacts of basis sets, solvent models, and NMR methods on the accuracy of 1H and 13C chemical shift calculations for biaryls : a DFT study ». Science and Technology Development Journal, 2024. http://dx.doi.org/10.32508/stdj.v27i1.4182.
Texte intégralCen, Shouyi, Shan-Shan Li, Yin Zhao, Mei-Xin Zhao et Zhipeng Zhang. « Catalytic Asymmetric Synthesis of Unnatural Axially Chiral Biaryl δ‐Amino Acid Derivatives via a Chiral Phenanthroline‐Potassium Catalyst‐Enabled Dynamic Kinetic Resolution ». Angewandte Chemie International Edition, 15 juin 2024. http://dx.doi.org/10.1002/anie.202407920.
Texte intégralCen, Shouyi, Shan-Shan Li, Yin Zhao, Mei-Xin Zhao et Zhipeng Zhang. « Catalytic Asymmetric Synthesis of Unnatural Axially Chiral Biaryl δ‐Amino Acid Derivatives via a Chiral Phenanthroline‐Potassium Catalyst‐Enabled Dynamic Kinetic Resolution ». Angewandte Chemie, 15 juin 2024. http://dx.doi.org/10.1002/ange.202407920.
Texte intégralNagaki, Aiichiro, Naofumi Takabayashi, Yutaka Tomida et Jun-ichi Yoshida. « Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems ». Beilstein Journal of Organic Chemistry 5 (29 avril 2009). http://dx.doi.org/10.3762/bjoc.5.16.
Texte intégralOhta, Misuzu, Ayano Okuda, Shoichi Hosoya, Yusuke Yoshigoe et Shinichi Saito. « Synthesis of Interlocked and Non‐Interlocked Deca(para‐phenylene) Derivatives by Ni‐mediated Biaryl Coupling ». Chemistry – A European Journal, 10 janvier 2024. http://dx.doi.org/10.1002/chem.202304309.
Texte intégralMoeinpour, Farid. « Unveiling the potential of Pd(II)‐covalent organic polyimide framework in Suzuki coupling reactions : A study on synthesis, characterization, and catalytic efficiency ». Applied Organometallic Chemistry, 19 décembre 2023. http://dx.doi.org/10.1002/aoc.7333.
Texte intégralThèses sur le sujet "Composés biarylés"
Di, Xiaohui. « Zéolithes dopées au cuivre(I) comme catalyseurs verts pour la synthèse organique ». Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF012.
Texte intégralAryl rings are a predominant feature in numerous biologically active compounds. Most of them can exist as biaryl, phenol, and tetrahydroisoquinoline moieties, which are encountered in many natural products and in various important synthetic intermediates. In the last few decades, various (transition) metal-catalyzed coupling reactions have emerged to synthesize such motifs or molecules via the formation of carbon-carbon bonds or carbon-heteroatom bonds. However, most of them were performed under homogeneous conditions with unsatisfactory reaction conditions, such as high temperatures, toxic solvents, and additional bases and ligands. To improve the greenness and sustainability of these processes, the potential of copper-doped zeolites as heterogeneous and recyclable catalysts was evaluated for the synthesis of biaryls, phenols, and tetrahydroisoquinoline derivatives through the study of several coupling reactions, such as homocoupling-type reactions, Chan-Lam-Evans-type cross-coupling and cross-dehydrogenative coupling reactions. Several efficient and economical catalytic procedures were developed under greener and milder conditions without the need for any additional ligand and base.Furthermore, the application of the so-obtained important biaryl motifs has also been explored in Diels–Alder reactions for the construction of heterocycles of interest with high atom economies
Barder, Timothy E. « Structural studies on biaryl phosphines and palladium complexes composed of biaryl phosphines ». Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39676.
Texte intégralThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Vita.
Includes bibliographical references.
Pd-catalyzed cross-coupling processes have become one of the most important and useful class of transformations in organic synthesis in the past 25 years. Supporting ligand design has been crucial in developing more effective catalysts. One highly effective class of ligand is that of biaryl phosphines. Herein are presented experimental and theoretical structural data on this class of phosphine that aids in elucidating what aspects of ligand architecture are beneficial for catalyst stability and reactivity. Additionally, examples of traditionally difficult Suzuki-Miyaura reactions are presented along with a fluorescent sensor that can be used to monitor boronic acid consumption in Suzuki-Miyaura reactions in situ. Finally, a rationale behind the resistance of dialkylbiaryl phosphines toward oxidation by molecular oxidation is described. Chapter 1. Expansion of the Suzuki-Miyaura Coupling Reaction. Chapter 2. X-Ray Crystal Structures of Biaryl Phosphine Pd(0) and Pd(II) Complexes. Chapter 3. Structural Insights into Active Catalyst Structures and Oxidative Addition to Biaryl Phosphine-Palladium Complexes via Density Functional Theory and Experimental Studies.
(cont.) Chapter 4. Structural Insights into Amine Binding to Biaryl Phosphine-Palladium Complexes via Density Functional Theory and Experimental Studies. Chapter 5. Experimental and Theoretical Analysis of an Arene/Phosphine Ligated Pd(I) Dimer. Chapter 6. A Rationale for the Resistance of Dialkylbiaryl Phosphines Toward Oxidation by Molecular Oxygen. Chapter 7. Benchtop Monitoring of Reaction Progress via Visual Recognition with a Handheld UV Lamp: In Situ Sensing of Boronic Acids in the Suzuki-Miyaura Reaction.
Timothy E. Barder.
Ph.D.
Coulomb, Julien. « Cyclisation radicalaire de sulfinates et de sulfinamides : substitution homolytique sur l'atome de soufre et formatin de composés biaryles ». Paris 6, 2006. http://www.theses.fr/2006PA066352.
Texte intégralAugros, David. « Synthèses de biaryles atropoenrichis et de biphénylènes via des arynes substitués ». Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF040/document.
Texte intégralThis work consisted in the study of the “aryne coupling”, a transition-metal free process to access biaryl moieties, which involves the reaction between two in situ generated intermediates: a nucleophilic aryllithium derivative and an electrophilic aryne. This work resided in the optimization of the atropoenantioselective version of the aryne coupling and its application to the formal synthesis of (-)-steganacin. We then moved to the atropoenantioselective version of the reaction, by introducing chiral ligands in the reaction mixture, which aim was to coordinate the aryllithium species and to transfer their chiral information to the biaryl axis. After optimization of various reaction parameters, some enantiomeric excesses were obtained as well as various side products in some cases, among which biphenylene derivatives. According to the potential applications of these compounds, another part of this work was dedicated to their synthesis by means of aryne dimerization reactions
Kazmierski, Igor. « Activation d'halogénures ou de pseudo-halogénures aromatiques et formation de liaisons carbone-carbone par catalyse au cobalt : synthèse et réactivité d'organozinciques aromatiques, synthèse de biaryles dissymétriques ». Paris 12, 2004. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990002139300204611&vid=upec.
Texte intégralTwo features of the catalysis by cobalt(I) complexes, in situ chemically generated from cobalt(II), are discussed in the present work. Firstly, a study of the synthesis of functionalized aromatic organozinc reagents has been undertaken in order to comprehend processes that were developped in the laboratory. This allowed the efficient synthesis of organozinc reagents under mild and optimized conditions, starting from aromatic bromides, as well as from the poorly reactive chlorides and phenol derivatives. Secondly, these organometallics were used in previously unreported cobalt-catalyzed carbon-carbon bond forming reactions, to obtain compounds such as functionalized phenones. The methodology could be extended to reactions that did not require the preparation of organozinc compounds, especially in the case of the synthesis of unsymmetrical biaryls
Rérat, Alice. « Couplages croisés catalysés au cobalt entre des arylzinciques et divers substrats électrophiles ». Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLX066/document.
Texte intégralThis thesis presents new cobaltcatalyzed cross-coupling reactions between arylzinc derivatives and various electrophilic reagents. After a general introduction on cobalt-catalysis and arylzinc compounds, the first chapter is dealing with the formation of diaryl ketones. Reaction between arylzinc bromides and ethyl chloroformate in presence of cobalt bromide and bipyridine ligand leads to the formation of symmetrical diaryl ketones with very good yields under simple conditions. It has been shown that ethyl chloroformate decomposes into carbon monoxide during the reaction. First attempts to extend this method to the synthesis of unsymetrical diaryl ketones are also described from arylzinc bromides and various carbonyl containing substrates. As for the second chapter, it is focused on the Negishi coupling between arylzinc bromides and an aryl bromide or an heteroaryl chloride. The advantage of this method is that the cobalt used to form the arylzinc bromide also serves to form the biaryl, hence there is no addition of another catalyst in the second step of the reaction. Results about the formation of biaryls are promising, but this reaction needs to be thorough. A similar methodology was used for the synthesis of new delayed fluorescence molecules to obtain highly efficient organic light emitting diodes. The third chapter describes the cobalt-catalyzed reaction between an arylzinc bromide and an electrophilic source of sulfur, a Bunte salt. However, these aryl sulfides can be easily oxidized in the reaction mixture and give sulfoxides and sulfones, which limit the use of this method. Finally, the last chapter is about preliminary works on the trifluoromethylation of arylzinc bromides from electrophilic or nucleophilic trifluoromethyl sources
Bouchitté, Corinne. « Synthèses en série aromatique : synthèse d'arylcyclopentyléthers, synthèse de biaryles catalysée par le nickel à partir d'aryllithiens ». Montpellier 2, 2000. http://www.theses.fr/2000MON20021.
Texte intégralYalcouye, Boubacar. « Synthèse atropo-sélective de la partie biarylique de la (-)-stéganacine via le couplage croisé de Suzuki-Miyaura et le couplage ARYNE ». Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF059.
Texte intégralThe interesting biological properties of axially chiral biaryls and the challenge of Csp2-Csp2 bond formation ofthe biaryl motif have aroused keen interest among synthetic organic chemists. The axially chiral biaryls areprivileged structures in medicinal chemistry and in asymmetric catalysis. The goal of our research is based onthe control of the axial chirality of (-)-steganacin using two differents atropo-selective approaches: Suzuki-Miyaura cross-coupling (in presence of transition metals), and ARYNE coupling (without any transitionmetals). The atropo-diastereoselective Suzuki-Miyaura cross-coupling was carried out using enantiopure β-hydroxysulfoxydes as chiral auxiliary. The resulting diastereopure biaryl was converted into an intermediatereported in the literature without any epimerization of axial chirality. The second approach was the atropodiastereoselectiveARYNE coupling which was tested for the first time with the enantiopure p-tolylsulfoxyde.However, we encountered a problem due to lack of reactivity of lithiated arylsulfoxide. Finally, the axialchirality of (-)-steganacin was controlled using oxazolines as chiral auxiliary
Demangeat, Catherine. « Vers le contrôle de la chiralité axiale des (hétéro)biaryles en l’absence de métaux de transition via le couplage ». Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0232.
Texte intégralThe aim of this thesis work was to provide novel access to axially chiral heterobiaryls following a transition metal free atropoenantioselective synthetic route. This project combines the Csp2-Csp2 Aryne coupling methodology, and an enantioselective approach, the ICE concept (ionic chiral environment). This concept relies on the implementation of chiral ligands as metal (Li) stabilizers with organolithium coupling partners. The chiral environment resulting from the chiral aggregates obtained must induce chirality during the coupling step. The first part of this work aimed to develop an heterocyclic version of the Aryne route in achiral conditions. The results of this study revealed a clear correlation between the electronic nature of the heterocyclic partner and its reactivity in the Aryne coupling. Thiophene, especially, proved to furnish promising results and allowed us to further develop the method. Second part of this work aimed to develop the reaction in the appropriate solvent conditions so that chiral mixed metal aggregates could be envisioned. This study outlined the remarkable effect of external chelating ligands (polyethers, polyamines, aminoalkoxides,…) and salt additives (Li, Zn, K,…) on the aryne coupling reaction in apolar media. The best reaction conditions emerging from this work were then successfully applied to others heterocyclic coupling partners. In parallel, theoretical calculations using density functional theory showed good agreement with experimental work and allowed us to propose mechanistic scheme for the reaction. Last part of this work focused on the reaction of hindered heterocyclic coupling partners with thiophene and benzothiophene derivatives
Kazmierski, Igor Gosmini Corinne. « Activation d'halogénures ou de pseudo-halogénures aromatiques et formation de liaisons carbone-carbone par catalyse au cobalt synthèse et réactivité d'organozinciques aromatiques, synthèse de biaryles dissymétriques / ». Créteil : Université de Paris-Val-de-Marne, 2004. http://doxa.scd.univ-paris12.fr:80/theses/th0213930.pdf.
Texte intégral