Livres sur le sujet « Compatibility effects »

This chapter provides a concise summary of pertinent information for 37 drugs that are administered by CSCI. Each monograph includes information relating to clinical pharmacology, indications, adverse effects, doses, drug interactions, and an exhaustive list of compatibility and stability data. Opioid equianalgesia is discussed because several opioids are used in palliative care and it is often necessary to either change the drug or route of administration as a patient’s condition changes.

International law regime of conflicts between treaties is obtained by combining the principles of the succession of treaties over time (the later treaty abrogates the earlier one) and the principle concerning the effects of treaties on third-party States (Pacta tertiis neque nocent neque prosunt). In fact, conflicts between treaties are not frequent as states prefer to negotiate in order to avoid them. Most of the time, negotiations lead to the inclusion in a treaty of declarations of ‘compatibility’ or ‘subordination’ with another or a series of other treaties. Some of them are analysed in this chapter.

Following the discovery of the ABO blood groups by Landsteiner in 1901, Albert Hustin described the first transfusion of a whole blood unit in 1914. The modern transfusion era really begins in 1916 with the discovery of sodium citrate as an anticoagulant by the same physician, allowing blood conservation in dedicated packs. Since that time, many advances have been made especially over the past two decades in the storage, the conservation, and the laboratory testing of blood components and in transfusion medicine practice. Transfusion of whole blood has been replaced by blood component therapy, which consists of the administration of packed red blood cells, fresh frozen plasma, or platelets. Although blood transfusion is safer than ever, the risk of complications will never reach zero. The risk of infectious transfusion-transmitted diseases has been markedly reduced by the implementation of extensive infectious disease testing, donor selection, and pathogen-inactivation procedures. In countries with a high human development index, the leading causes of allogeneic blood transfusion-related deaths actually resulted from immunological and septic complications. The first section of this chapter describes the structure, function, and immunological aspects of the different blood components that are routinely transfused today. The second section details the composition of the different blood components, their indications, the pre-transfusion compatibility tests, and the main adverse effects associated with their transfusion.

An eighteenth-century musical topic is a familiar figure, texture, genre, or style that is imported into a new context, where it may interact with other topics and the prevailing discourse of a movement in ways that may spark creative meanings. These interactions are analogous to the processes that produce tropes in literary language. A merger of expressive meanings may produce an effect akin to metaphor, whereas resistance to merger may signal some form of irony. Degrees of compatibility, dominance, creativity, and productivity among topics and tropes are explored in Mozart’s instrumental works, with extended examples drawn from the first movements of Mozart’s Piano Sonatas in F major, K. 332, and D major, K. 576, and the second and fourth movements of his String Quartet in D minor, K. 421.

In our times of globalisation, an effective employment law that transcends national borders is of great public interest. In a project funded by the DFG (Germany’s central research funding organisation), the potential of transnational social dialogues in Europe to shape society innovatively was examined. To this end, 2500 agreements of European works councils and social dialogues according to the TFEU that are either specific to one industry or relate to a number of sectors, transnational company agreements and multi-actor agreements were collected, coded and comparatively assessed. Social dialogues have brought about innovations in employment law and/or have concretised abstract norms in the context of industry, as this study proves in the areas of health and safety, information and consultation, anti-discrimination rights and compatibility with European legal regulations. However, this study finds that in order for transnational social dialogues to have a sustainable effect in their approach to setting standards, they require more legal support on both a national and European level.

Population genetics is an inherently quantitative discipline. Because the focus of population genetics studies is usually on abstract concepts like the frequencies of genetic variants over time, it can at first glance be difficult to conceptualize and appropriately visualize. As more and more quantitative models and methods have become established in the discipline, it has become necessary for people just entering the field to quickly develop a good understanding of the many layers of complex approaches, so as to correctly interpret even basic results. An unfortunate side effect of the widespread implementation of ready-to-use quantitative software packages is that some facets of analysis can become rote, which at best might lead to implementation without the full understanding of the user and at worst, inappropriate application leading to misguided conclusions. In this book a “learning by doing” approach is employed to encourage readers to begin developing an intuitive understanding of population genetics concepts. The analytical software R, which has increasingly been the program of choice for early exposure to basic statistical programming, is freely available online, has cross-platform compatibility (Windows, Mac, and Linux all support distributions of R), and offers the potential for hands-on implementation by the students, in addition to using pre-packaged functions.

The quality of data collected in official spatial databases is crucial in making strategic decisions as well as in the implementation of planning and design works. Awareness of the level of the quality of these data is also important for individual users of official spatial data. The author presents methods and models of description and evaluation of the quality of spatial data collected in public registers. Data describing the space in the highest degree of detail, which are collected in three databases: land and buildings registry (EGiB), geodetic registry of the land infrastructure network (GESUT) and in database of topographic objects (BDOT500) were analyzed. The results of the research concerned selected aspects of activities in terms of the spatial data quality. These activities include: the assessment of the accuracy of data collected in official spatial databases; determination of the uncertainty of the area of registry parcels, analysis of the risk of damage to the underground infrastructure network due to the quality of spatial data, construction of the quality model of data collected in official databases and visualization of the phenomenon of uncertainty in spatial data. The evaluation of the accuracy of data collected in official, large-scale spatial databases was based on a representative sample of data. The test sample was a set of deviations of coordinates with three variables dX, dY and Dl – deviations from the X and Y coordinates and the length of the point offset vector of the test sample in relation to its position recognized as a faultless. The compatibility of empirical data accuracy distributions with models (theoretical distributions of random variables) was investigated and also the accuracy of the spatial data has been assessed by means of the methods resistant to the outliers. In the process of determination of the accuracy of spatial data collected in public registers, the author’s solution was used – resistant method of the relative frequency. Weight functions, which modify (to varying degree) the sizes of the vectors Dl – the lengths of the points offset vector of the test sample in relation to their position recognized as a faultless were proposed. From the scope of the uncertainty of estimation of the area of registry parcels the impact of the errors of the geodetic network points was determined (points of reference and of the higher class networks) and the effect of the correlation between the coordinates of the same point on the accuracy of the determined plot area. The scope of the correction was determined (in EGiB database) of the plots area, calculated on the basis of re-measurements, performed using equivalent techniques (in terms of accuracy). The analysis of the risk of damage to the underground infrastructure network due to the low quality of spatial data is another research topic presented in the paper. Three main factors have been identified that influence the value of this risk: incompleteness of spatial data sets and insufficient accuracy of determination of the horizontal and vertical position of underground infrastructure. A method for estimation of the project risk has been developed (quantitative and qualitative) and the author’s risk estimation technique, based on the idea of fuzzy logic was proposed. Maps (2D and 3D) of the risk of damage to the underground infrastructure network were developed in the form of large-scale thematic maps, presenting the design risk in qualitative and quantitative form. The data quality model is a set of rules used to describe the quality of these data sets. The model that has been proposed defines a standardized approach for assessing and reporting the quality of EGiB, GESUT and BDOT500 spatial data bases. Quantitative and qualitative rules (automatic, office and field) of data sets control were defined. The minimum sample size and the number of eligible nonconformities in random samples were determined. The data quality elements were described using the following descriptors: range, measure, result, and type and unit of value. Data quality studies were performed according to the users needs. The values of impact weights were determined by the hierarchical analytical process method (AHP). The harmonization of conceptual models of EGiB, GESUT and BDOT500 databases with BDOT10k database was analysed too. It was found that the downloading and supplying of the information in BDOT10k creation and update processes from the analyzed registers are limited. An effective approach to providing spatial data sets users with information concerning data uncertainty are cartographic visualization techniques. Based on the author’s own experience and research works on the quality of official spatial database data examination, the set of methods for visualization of the uncertainty of data bases EGiB, GESUT and BDOT500 was defined. This set includes visualization techniques designed to present three types of uncertainty: location, attribute values and time. Uncertainty of the position was defined (for surface, line, and point objects) using several (three to five) visual variables. Uncertainty of attribute values and time uncertainty, describing (for example) completeness or timeliness of sets, are presented by means of three graphical variables. The research problems presented in the paper are of cognitive and application importance. They indicate on the possibility of effective evaluation of the quality of spatial data collected in public registers and may be an important element of the expert system.