Thèses sur le sujet « Collisions de la route »
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Snyder, Sara Ann. « Examining the impacts of State Route 101 on wildlife using road kill surveys and remote cameras ». DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1296.
Texte intégralWills, Johnny. « DNA-based hair sampling to identify road crossings and estimate population size of black bears in Great Dismal Swamp National Wildlife Refuge, Virginia ». Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/34932.
Texte intégralThe planned widening of U.S. Highway 17 along the east boundary of Great Dismal Swamp National Wildlife Refuge (GDSNWR) and a lack of knowledge about the refugeâ s bear population created the need to identify potential sites for wildlife crossings and estimate the size of the refugeâ s bear population. I collected black bear hair in order to collect DNA samples to estimate population size, density, and sex ratio, and determine road crossing locations for black bears (Ursus americanus) in GDSNWR in southeastern Virginia and northeastern North Carolina. I also investigated bear/vehicle collisions to determine patterns of road crossing.
Genetic analysis of 344 hair samples collected on 2 trapping grids identified 85 unique individuals which I used in a mark-recapture analysis. Estimated population size on the trapping grids was 105 bears (95% CI = 91-148) and average density was 0.56 bears/km2. This density estimate projected over the entire Great Dismal Swamp ecosystem yielded a population estimate of 308 bears (550 km2 X 0.56 bears/km2). Similar population estimates generated by Hellgren (1988), Tredick (2005), and this study suggest a stable bear population in the Great Dismal Swamp ecosystem over a 20-year period.
I erected a 2.3-kilometer long strand of barbed wire along U. S. Highway 17 to monitor road crossing patterns near the Northwest River drainage. Genetic analysis identified 6 bears (4 males, 1 female, 1 unknown) that apparently crossed the highway in a 10-month period. Five of 6 bears deposited hair in a 171-m section which included the Northwest River corridor. The 6 bears detected crossed the road at least 11 times.
I investigated 10 reports of bear/vehicle collisions on the periphery of the refuge from June 2000 to May 2002. Six bears (4M:1F:1 unknown) were confirmed killed during this time period. Based on reported bear/vehicle collisions from Hellgren (1988), the Virginia Department of Game and Inland Fisheries database, and this study, a minimum of 4 to 5 bears are struck by vehicles each year on the periphery of the refuge. I identified 2 areas of multiple bear/vehicle collisions: highway 58 on the north side of the refuge near Hampton Airport and Highway 17 on the eastern side of the refuge in the vicinity of the Northwest River corridor.
Master of Science
Youssef, Dalal. « Améliorer la sécurité routière au Liban : un parcours multidimensionnel allant de l'analyse exhaustive des défis à l'intégration des données et l'examen du comportement des conducteurs ». Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0268.
Texte intégralRoad traffic collisions, a global public health and socio-economic concern, claim 1.19 million lives annually worldwide. Lebanon, with a population under 6 million, contends with nearly 1,000 road fatalities each year. Challenges are amplified by population growth, increased household vehicle ownership, deteriorating infrastructure, and the enduring impact of regional conflicts, all further obscured by fragmented data. The dearth of prior research on Lebanese road safety compounds the predicament, impeding informed policy formulation and precise solutions. The thesis unfolds along two main axes: road safety management and driver behaviour. The first axis provides a comprehensive analysis of the current state of road safety management in Lebanon. This analysis delves deeply into the challenges, as well as the historical, institutional, organizational, and financial complexities that shape the current framework for road safety. The thesis evaluates existing policies, enforcement mechanisms, budget allocations, and proposes evidence-based recommendations to improve both road safety and sustainability in Lebanon. This thorough analysis highlights the urgent need for a holistic strategy that covers a wide range of road safety aspects, from strict law enforcement to infrastructure improvements, sustainable funding allocation, and active international collaboration. Recognizing that data is the cornerstone of effective road safety management, the thesis addresses briefly the critical issue of fragmented and incomplete data on road traffic injuries in Lebanon. Focusing on the human factor, the second axis concentrates on driver behaviour, a key element of road safety that has lacked validated tools in the Lebanese context. The thesis advocates for the cross-cultural adaptation of four measurement scales (Traffic Locus of Control, Driver Behaviour Questionnaire, Driving Anger Scale, and Driver Skills Inventory) to understand and mitigate risky driver behaviours. This complex process involves translation, cross-cultural adaptation, rigorous validation, and the involvement of various groups of Lebanese drivers in data collection. Beyond validation, it explores the relationship between driver behaviour and road collisions, with the potential to influence road safety policies and promote good driving practices. This thesis thus serves as a transformative roadmap, aiming to create safer roads, reduce collisions, and improve the quality of life in Lebanon. It is a clarion call to address the urgent need for action and the pursuit of data-driven solutions
Despringre-Bessière, Karine. « Détection d'obstacles sur route par télémétrie laser : évaluation des caractéristiques d'un système intégré ». Grenoble INPG, 1996. http://www.theses.fr/1996INPG0071.
Texte intégralGupta, Anil K. « An algorithm to solve traveling-salesman problems in the presence of polygonal barriers ». Ohio : Ohio University, 1985. http://www.ohiolink.edu/etd/view.cgi?ohiou1184007096.
Texte intégralAugé, Patrick. « Spécification, modélisation et vérification d'une architecture multi-agents dédiée à la gestion des risques de collision automobile ». Paris 11, 2001. http://www.theses.fr/2001PA112345.
Texte intégralComputer sciences take a rising place in various industrial systems, complex spatial equipment are for instance controlled by computer systems. The equipment operates correctly when the behavior of the computer part is correct. Thus, verification methods are of great importance, as they prove the correct behavior according to rigorous and exhaustive analyses based on strong theories, the methods also bring appropriated tools. Within the verification scheme, a model of the system is described using languages which semantics associate to the model a state graph that represents all possible executions. This space makes it possible the identification of such states or sequences which are not allowed. The construction of this graph may lead to the combinatorial explosion problem. This key step takes thus preponderant place in this thesis, here are considered various construction strategies with reduction, based on partial orders and equivalency relations : verification tools implementing these strategies are compared according to various classical case studies. A more complex case study, that concerns an agent based system dedicated to road collision risks management, has also been dealt with. Consequently, specification, graph construction and verification aspects were considered. This part of the study associates researchers from different areas, highlighting key points of complex systems design. This collaboration allowed the definition of abstractions, focusing on interactions, reducing thus the size of state graphs, making possible the verification step. Modeling, within tools languages, of parallel processing, led us to propose several control schemes which verifications all succeeded
Revue, Alexandre. « Contribution des systèmes d'information géographiques à la sécurité routière : approche multicapteurs pour l'évaluation de configurations à risques ». Paris, ENMP, 2003. http://www.theses.fr/2003ENMP1147.
Texte intégralPoulard, David. « Influence de l’âge et du morphotype sur la réponse mécanique du thorax : étude expérimentale in vivo et analyse numérique à l'aide de modèles EF personnalisés du corps humain ». Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10332/document.
Texte intégralThis study deals with the topic of increased risk of rib fractures among elderly drivers infrontal impact. The analysis of the literature reveals that actual thorax injury assessment tools do nottake into account for the differences in anatomical features and biological material properties observedbetween adults and elderly. Personalized human body finite element (FE) models have great potentialas improved thorax injury assessment tools. However, experimental data are needed to validate thesemodels under real-world conditions. In addition, the choice of the level of personalization of the modeland the sensibility of the model response to this personalization must be assessed to predict thoracicinjury risk.In vivo sled tests were performed on belted volunteers of various anthropometries and age. These testswere used to assess the influence of age and corpulence on thorax mechanical response and allowed toobtain corridor responses needed to validate personalized FE models. The geometry of the FE modelTHUMS was adapted to the volunteers and the thorax material properties were modified consideringaging to carry out a similar analysis in the injurious domain. Numerical simulations highlighted anincreased risk of rib fractures for specific personalized models.This study should help to better estimate the injury risk for car occupants. It should contribute topromote personalized human body models as attractive thorax injury assessment tool ofvulnerable individuals
Hartmann, Jean-Michel. « Etude de l'absorption infra-rouge par des mélanges gazeux HO-CO-CO-Air à température élevée modélisation, pour l'ingénieur, des propriétés radiatives, approches théorique et expérimentale de l'élargissement par collisions ». Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37599390v.
Texte intégralRevue, Alexandre. « Contribution des systèmes d'informations géographiques à la sécurité routière : approche multicapteurs pour l'évaluation de configurations à risques ». Phd thesis, École Nationale Supérieure des Mines de Paris, 2003. http://pastel.archives-ouvertes.fr/pastel-00000833.
Texte intégralHartmann, Jean-Michel. « Etude de l'absorption infra-rouge par des mélanges gazeux H2O-CO2-CO-Air à température élevee : modélisation, pour l'ingenieur, des propriétés radiatives : approches théorique et expérimentale de l'élargissement par collisions de raies de H2O et CO ». Châtenay-Malabry, Ecole centrale de Paris, 1986. http://www.theses.fr/1986ECAP0013.
Texte intégralHenderson, Ryan Lynn. « Magnolia Star Route ». Master's thesis, Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-04092007-130126.
Texte intégralKantak, Advait Ashok. « Wet particle collisions ». Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p3190381.
Texte intégralNesbitt, Brian. « Heavy-particle collisions ». Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301028.
Texte intégralHolmquist, John. « NAVIGATION AIDS IN ROUTE TRAINING : INCREASE NAVIGATION SPEED, DECREASE ROUTE RETENTION ? » Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4014.
Texte intégralPh.D.
Other
Engineering and Computer Science
Modeling and Simulation
Fulati, Tayierjiang. « Route de la soie, route de la création : rencontres, frontières, contacts, croisements ». Thesis, Paris 1, 2017. http://www.theses.fr/2017PA01H306/document.
Texte intégralRelying on my personal artistic practice, this thesis analyzes the identity, origin, the value and the place of the "band" in the art in weaving through the old Silk Road. The analysis of my artistic creation, my culture, my multiple identities and my influences in the light of the legacy of the Silk Road and the road of the creation. The crossing of the Silk Road is structured around four themes : the meeting, contact. The crossing and the border. The research led me on a messianic trip, in the aim of finding answers to the questions that concern me : how the Silk Road influences artistic creation, is it a source of creativity? How can it be in the works of contemporary artists? How it emerges on my artistic creation? To answer these questions, I presented my band as a figure, which binds me to my multiple origins. In the first chapter I will analyze the concept of identity through the portraits of the band, then I will look into the notion of border visible and invisible. In the third chapter, I will analyze the touch, the taste and the crossing with the Silk Road. Finally, I will examine the context of interior landscapes and I will try to demonstrate the hidden legacy as well as the secrets of the local art impregnated in the culture of our region through crosses and cultural mixes
Tezcaner, Diclehan. « Multi-objective Route Selection ». Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610767/index.pdf.
Texte intégralminimizing distance traveled and minimizing radar detection threat
and proposed heuristics for the minimization of the composite single objective problem. We treat these two objectives separately. We develop an evolutionary algorithm to determine the efficient tours. We also consider an exact interactive approach to identify the best paths and tours of a decision maker. We tested the two solution approaches on both small-sized and large-sized problem instances.
Nikwigize, Adolphe. « Graph theory : Route problems ». Thesis, Linnéuniversitetet, Institutionen för datavetenskap, fysik och matematik, DFM, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-17397.
Texte intégralBottom, Jon Alan. « Consistent anticipatory route guidance ». Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/31095.
Texte intégralIncludes bibliographical references (p. 241-251).
Anticipatory route guidance consists of messages, based on traffic network forecasts, that assist drivers' path choice decisions. Guidance is consistent when the forecasts on which it is based are verified after drivers react to it. This thesis addresses the formulation and development of solution algorithms for the consistent anticipatory route guidance generation (RGG) problem. The thesis proposes a framework for the problem, involving a set of time-dependent variables and their relationships. Variables are network conditions, path splits and guidance messages. Relationships are the network loading map, transforming path splits into network conditions; the guidance map, transforming network conditions into guidance messages; and the routing map, transforming guidance messages into path splits. The basic relationships can be combined into three alternative composite maps that model a guidance problem. Consistent guidance corresponds to a fixed point of a composite map. With stochastic maps, RGG model outputs are stochastic process realizations. In this case, the consistency fixed point corresponds to stationarity of the RGG solution process. Numerical methods for fixed point computation were examined, focusing on approaches that are rigorous and applicable to large-scale problems. Methods included Gibbs sampling for highly stochastic maps; generalizations of functional iteration for deterministic maps; and the MSA and Polyak iterate averaging method for "noisy" (deterministic plus disturbance) maps. A guidance-oriented dynamic traffic simulator was developed to experiment with RGG solution methods. Computational tests using the simulator investigated the use of Gibbs sampling to compute general stochastic process outputs; and examined the performance of the averaging methods under different model formulations, problem settings and degrees of stochasticity. Gibbs sampling successfully generated realizations from the stationary solution process of a fully stochastic model, but entails considerable computational effort. For noisy problems, the MSA found fixed points in all cases considered. Polyak averaging converged between two and four times faster than the MSA in low or moderate stochasticity problems, and performed comparably to the MSA in other problems. Formulations involving path-level variables converged more quickly than those involving link-level variables.
by Jon Alan Bottom.
Ph.D.
Hultman, Tim. « Signal-Aware Route Planning ». Thesis, Linköpings universitet, Programvara och system, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128101.
Texte intégralMackman, Richard Laurence. « Isobacteriochlorins : a novel route ». Thesis, University of Cambridge, 1992. https://www.repository.cam.ac.uk/handle/1810/272523.
Texte intégralPlanchette, Carole. « Collisions de gouttes asymétriques ». Phd thesis, Université Paris-Est, 2011. http://tel.archives-ouvertes.fr/tel-00647892.
Texte intégralMcGuinness, Philip. « Electron-ion elastic collisions ». Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268236.
Texte intégralCopeland, Fiona B. M. « Low energy rearrangement collisions ». Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318881.
Texte intégralMcAlinden, Mary Trea. « Atomic collisions involving positrons ». Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317480.
Texte intégralGrishkevich, Sergey. « Ultracold collisions in traps ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16098.
Texte intégralThe ultracold atomic and molecular physics as it is accessible, e.g., in Bose-Einstein condensates of dilute gases was investigated. In such systems two-body collisions are dominant and their detailed study is one of the central topics of this work. They were done considering elementary chemical reactions as photoassociation, and magnetic Feshbach resonances. Additionally, studies of atoms in optical lattice sites were carried out. The many-body systems were not only considered within the usually adopted mean-field approach but also beyond that in order to simulate the fully correlated motion.
O'Connor, Daryl John. « Atomic collisions with surfaces ». Thesis, Canberra, ACT : The Australian National University, 1997. http://hdl.handle.net/1885/144473.
Texte intégralShin, Doh Kyoum. « Explanation of factors influencing cyclists' route choice using actual route data from cyclists ». Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13532/.
Texte intégralGillman, Malin. « Eco-route modelling using GIS : How to find the most sustainable route option ». Thesis, Umeå universitet, Institutionen för geografi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185860.
Texte intégralMack, S. K. « Single-route and dual-route approaches to reading aloud difficulties associated with dysphasia ». Thesis, Queen Margaret University, 1999. https://eresearch.qmu.ac.uk/handle/20.500.12289/7453.
Texte intégralPeng, Zhongren. « A Simultaneous Route-level Transit Patronage Model : Demand, Supply, and Inter-route Relationship ». PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/1159.
Texte intégralDahl, Valerie, et Mikael Davidsson. « Route flow estimation based on time-dependent route choice sets and historical travel times ». Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130007.
Texte intégralKelly, Joseph Pierre. « Route to administrative licensure perceptions of preparation regarding traditional and examination route assistant principals / ». Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1971755291&sid=11&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Texte intégralBasu, Nandita. « Pedestrian route choice behaviour : Influences of built environment on route preference, safety and security ». Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/236797/1/Thesis_Nandita%2BBasu_24112022.pdf.
Texte intégralFranck, Martin, et Roos Malin Holm. « COLLISIONS IN ICE : A STUDY OF COLLISIONS INVOLVING SWEDISH ICEBREAKERS IN THE BALTIC SEA ». Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-25468.
Texte intégralDenna studie genomfördes i syfte att utöka den akademiska kunskapen om kollisioner sominvolverar svenska isbrytare i Östersjön. Den ämnade identifiera orsakerna och de omedelbaraeffekterna av dessa kollisioner. Vidare sökte den fastslå huruvida regelverk och riktlinjer förden svenska isbrytartjänsten var tillräckliga och om de efterlevdes.Studien genomfördes som en kvalitativ litteraturstudie av all data, med anknytning tillisbrytarkollisioner, som fanns tillgänglig i Sjöfartsverkets och Transportstyrelsens arkiv. Ettflertal utländska myndigheter som utreder olyckor assisterade vid framtagandet av modellenför bearbetning av datan.Efter att ha bearbetat och undersökt datan kunde förekomsten av olika bidragande orsaker tillisbrytarkollisionerna slås fast. Alla kollisioner inträffade under isbrytarassistans. Det stodklart att den övergripande orsaken var svårigheten i att utvärdera isförhållandena och deåtgärder fartygen tvingas vidta för att kunna ta sig fram genom isen. Vidare fastslogs att deomedelbara effekterna, för såväl fartyg som besättning och miljö, inte var förödande utan avbegränsad karaktär. Det fastslogs även att de regelverk och riktlinjer som styr den svenskaisbrytarverksamheten överlag efterlevdes och var tillräckliga för att säkerställa entillfredställande säker och effektiv isbrytartjänst.
Billot-Grasset, Alice. « Typologie des accidents corporels de cyclistes âgés de 10 ans et plus : un outil pour la prévention ». Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10025/document.
Texte intégralIn many major cities, the growing modal share of cycling, mainly supported by public policies, raises the issue of cycling safety. Most of the existing work on this topic is based on police data. However, these data underreport cyclists, especially the victims of single accidents. In France, a recent study based on the Rhône road trauma registry, a medical database covering almost all cyclist falls or collisions, considers that a cyclist is 8 times more likely to be injured than a driver by hour spend on a road. The same review also reveals an increased risk of crash for women. Based on these observations, this thesis comes up with a full picture of cycling accidents, taking into account accident factors identified in the literature. The proposed work offers a better understanding on how the cyclist’s behavior interacts with them. It aims to describe accident configurations to propose preventive primary and secondary safety actions. To do so, we surveyed 3337 cyclists injured in 2009-2011 and identified in the Rhône Road Trauma Registry. Based on a significant response rate, descriptive analyses improve existing knowledge in cycling safety, some accident factors being examined for the first time in our survey. Following these analyses, gender roles were unclear, justifying an intensive investigation on cycling accidents through the prism of gender. In order to achieve this goal, we select the 44 accidents on utilitarian trips and built a logistical regression model to explain the likelihood that the victim is a woman. All factors being equal, when a injured cyclist had a load on his bike, did not know the route, fell ascending or descending a curbside, it is more likely that the victim is a woman. Conversely, the probability for the victim to be a men increases if the cyclist’s speed is one of the accident factors. These results are confirmed and illustrated analyzing textual data on accidents stories. The last part is dedicated to a proposal of a set of actions and ideas aiming at improving cycling safety. Some research perspectives are proposed to address the weaknesses of the thesis work
Stefanius, K. (Karoliina). « Colorectal carcinogenesis via serrated route ». Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514293993.
Texte intégralTiivistelmä Paksu- ja peräsuolisyöpä eli kolorektaalisyöpä on Suomessa kolmanneksi yleisin syöpätyyppi. Syöpää edeltävien muutosten tunnistaminen on tärkeää, jotta sen ehkäisy ja seuranta olisi tehokasta. Tavallisia adenoomapolyyppeja on pidetty tärkeimpinä kolorektaalisyövän esiastemuutoksina. 2000-luvulla on havaittu, että nk. sahalaitapolyypit edustavat tärkeää osaa esiastemuutoksista, ja näistä kehittyvää syöpää kutsutaan sahalaitaiseksi syöväksi. Sahalaitaisen syövän kehittymismekanismit eroavat huomattavasti tavallisesta kolorektaalisyövästä. Tässä väitöskirjassa keskityttiin tutkimaan sahalaitaiselle syövälle tyypillisiä morfologisia piirteitä sekä geneettisiä muutoksia. Työssä selvitettiin DNA mikrosatelliitti-instabiliteetin sekä DNA korjausgeenien hMLH1 ja MGMT promoottorialueiden hypermetylaation esiintyminen, nk. MAPK –signaalinsiirtoreitin komponenttien, KRAS ja BRAF -geenien, mutaatioiden yleisyys sekä PTCH1 geenin mutaatiokirjo sahalaitaisissa (n=42) ja tavallisissa kolorektaalisyövissä (n=75). DNA:n mikrosatelliitti-instabiliteetti, erityisesti matala-asteisena (MSI-L) (p=0.02) sekä MLH1 ja hMGMT -geenien metylaatio (p=0.004, p=0.026) olivat yleisempiä sahalaitaisissa syövissä. BRAF mutaatio oli yleinen sekä spesifinen sahalaitasyöville (p<0.001). Myös KRAS -mutaatiot olivat yleisempiä sahalaitaisissa syövissä (p=0.002). BRAF mutaatio, hMLH1 sekä MGMT metylaatio ja korkea-asteinen mikrosatelliitti-instabiliteetti (MSI-H) esiintyivät hyvin usein yhdessä sahalaitaisissa syövissä. Sahalaitaisissa syövissä KRAS –mutaatiot liittyivät MSI-L fenotyyppiin. hMLH1 geenin ilmentyminen tutkittiin myös immunohistokemiallisesti. Sahalaitaisissa syövissä MLH1 –proteiinin häviäiminen oli yhteydessä metylaatioon ja liittyi spesifisesti MSI-H:n esiintymiseen (p < 0.0001). PTCH1 geenin sekvensointi ei paljastanut proteiinin toimintaa vahingoittavia muutoksia, eikä tuloksen perusteella pystytä selittämään aikaisemmin havaittua geenin ilmentymisen häviämistä sahalaitaisessa syövässä. Tulosten perusteella sahalaitainen syöpä on oma, mutta heterogeeninen kolorektaalisyövän alatyyppi. KRAS ja BRAF –geenien aktivoivien mutaatioiden yleisyys (79–82%) osoittaa, että MAPK -reitin aktivaatio on tärkeää sahalaitaisen syövän kehityksessä. BRAF -mutaatiot ovat spesifisiä sahalaitaisille syöville, ja yhdessä metylaation sekä MSI-H:n kanssa identifioi osan sahalaitasyövistä omaksi ryhmäkseen. KRAS –mutaatioiden yleisyys sahalaitaisissa syövissä antaa aiheen epäillä, että merkittävä osa KRAS –mutaation sisältävistä kolorektaalisyövistä kehittyy sahalaitapolyypeista
Weetman, John. « A new route to oligonucleotides ». Thesis, University of Leicester, 1985. http://hdl.handle.net/2381/33983.
Texte intégralZhang, Xiaohui. « A cycloaddition route to pyrrolidines ». Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439241.
Texte intégralFarver, Jennifer M. (Jennifer Margaret) 1976. « Hybrid vehicle-centric route guidance ». Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33689.
Texte intégralIncludes bibliographical references (p. 223-228).
This thesis proposes a hybrid route guidance system in which predictive guidance is generated in a centralized layer and revised in a reactive, decentralized layer that resides on-board the vehicle. This hybrid approach is intended to improve guidance quality by balancing the ability of the centralized layer to generate consistent guidance with the ability of the decentralized layer to respond rapidly to incidents. Centralized guidance is computed using a rolling-horizon Dynamic Traffic Assignment routine based on the Method of Successive Averages. This guidance is disseminated to equipped vehicles in the form of prescribed paths, which may be subsequently revised by an on-board decentralized layer. This decentralized layer revises only the local portion of the vehicle's path in order to limit the potential negative impact of its myopic reactive algorithm. The layer uses a simple splitting algorithm in order to heuristically balance demand on alternate paths. Both layers utilize data collected by guided vehicles. The centralized layer uses position data from guided vehicles. The decentralized layer uses local arc travel time data which is shared among guided vehicles.
(cont.) This approach follows the vision of a vehicle-centric route guidance system whose design is focused on the vehicle, rather than on stationary components. In order to test the performance of the proposed system, a small test network is simulated in a simple network simulator. The primary experimental questions are: whether the hybrid system provides higher quality route guidance than either a fully centralized or fully decentralized system; and how hybrid guidance quality is affected by various parameters of the system and the testing environment. Results of testing confirm that the hybrid system provides higher quality guidance than either centralized or decentralized systems in most scenarios; in no scenario is the hybrid system found to perform measurably worse than the centralized or decentralized system. The greatest benefits of the hybrid system are found to be in incident scenarios, supporting the hypothesis that the decentralized layer may aid incident response.
by Jennifer Margaret Farver.
Ph.D.
Ramming, Michael Scott. « Network knowledge and route choice ». Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/49797.
Texte intégralIncludes bibliographical references (p. 225-236).
Models of urban traveler route choice are reviewed in the context of Intelligent Transportation Systems, particularly Advanced Traveler Information S ystems. Existing models suffer from assumptions of perfect information about travel conditions a nd infinite information processing capabilities of drivers. We present evidence that a majority of travelers fail to minimize travel time or distance. We also show that travelers with more network knowledge appear to vary their commute route to respond to changing travel conditions. Coefficient estimates of a model of network knowledge, based on the geographical idea of spatial ability, are presented. To better understand habitual route choice behavior, we examine many possible route generation algorithms. A simulation approach is preferred because it allows for heterogeneity in driver perceptions and it has a quick computational time. Alternative route choice model specifications such as Multinomial Logit, C-Logit, Path Size Logit, Cross-Nested Logit and Logit Kernel Probit are evaluated. The exponential specification of the Path S ize term, using a large parameter value, offers a considerable improvement in fit over MNL, C -Logit and CNL. A hybrid Path Size Logit and Logit Kernel Probit model offers the best overall fit; however, the stability of these estimates requires further examination. The hybrid Path S ize Logit and CNL model provides the next best empirical fit. Random coefficient specifications of MNL, PS L and LK Probit models were also examined.
Significant random coefficient parameter estimates were only obtained for the MNL model. This result suggests that random coefficients capture variation in route choice models that would be more effectively explained by a Path S ize or LK Probit specification. Model fit can be further improved by adding an Implicit Availability/Perception term that includes estimated network knowledge. However, this term provides limited explanatory power, as can be seen by its standard errors and by forecasts that are relatively insensitive to changes in traveler knowledge. These results suggest that continued development of better attitudinal surveys to assess network knowledge and wayfinding strategies would allow estimation of route choice models with better explanatory power.
by Michael Scott Ramming.
Ph.D.
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Texte intégralLoreau, Tanguy. « Construction automatique de modèles multi-corps de substitution aux simulations de crashtests ». Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLC082/document.
Texte intégralAt Renault, to fulfill upstream studies, teams in charge of crashworthiness use very simple models to pre-size the vehicle. Today, these models are built from the physical behavior of only one or some reference vehicles. They work and allow to size the project. But today, the company wishes to build its upstream models using all its vehicles. In other words, it wishes to get an automatic method to analyze crashtests simulations to capitalize their results in a database of simplified models.To meet this goal, we decide to use the multi-body model theory. We develop a method to analyze crashtests simulations in order to extract the data required to build a surrogate multi-body model : CrashScan. The analysis process implemented in CrashScan can be split into three major steps.The first one allows to identify the low deformed zones on a crashtest simulation. Then, we can build the topological graph of the future surrogate model. The second step is to analyze the relative kinematics between the low deformed zones : major directions and deformation modes (e.g. crushing or bending) are identified analysing relative movements. The last step is to analyze strengths and moments located between the low deformed zones, viewed in the frames associated to the major directions of deformations in function of the deformations. This allows us to identify equivalent Bouc-Wen hysteretic models. These models have three parameters that we can use : a stiffness, a threshold strength before plastification and a strain of hardening. These parameters can directly be used by upstream studies experts.Finally, we build multi-body models for three different use case. We compare them to their reference over the results they produce for the upstream criteria : models generated with CrashScan seems to grant the precision and the fidelity required to be used during automotive development's upstream phases.To continue this research work and get an industrial solution, there are still some locks to lift, the main ones are : synthesis of any movement into six elementary ones and multi-body synthesis on elements other than beams
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