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Littérature scientifique sur le sujet « CINP »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "CINP"

Fleming, James A., Leticia R. Vega et Frank Solomon. « Function of Tubulin Binding Proteins in Vivo ». Genetics 156, n^o 1 (1 septembre 2000) : 69–80. http://dx.doi.org/10.1093/genetics/156.1.69.

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Abstract Overexpression of the β-tubulin binding protein Rbl2p/cofactor A is lethal in yeast cells expressing a mutant α-tubulin, tub1-724, that produces unstable heterodimer. Here we use RBL2 overexpression to identify mutations in other genes that affect formation or stability of heterodimer. This approach identifies four genes—CIN1, CIN2, CIN4, and PAC2—as affecting heterodimer formation in vivo. The vertebrate homologues of two of these gene products—Cin1p/cofactor D and Pac2p/cofactor E—can catalyze exchange of tubulin polypeptides into preexisting heterodimer in vitro. Previous work suggests that both Cin2p or Cin4p act in concert with Cin1p in yeast, but no role for vertebrate homologues of either has been reported in the in vitro reaction. Results presented here demonstrate that these proteins can promote heterodimer formation in vivo. RBL2 overexpression in cin1 and pac2 mutant cells causes microtubule disassembly and enhanced formation of Rbl2p-β-tubulin complex, as it does in the α-tubulin mutant that produces weakened heterodimer. Significantly, excess Cin1p/cofactor D suppresses the conditional phenotypes of that mutant α-tubulin. Although none of the four genes is essential for viability under normal conditions, they become essential under conditions where the levels of dissociated tubulin polypeptides increase. Therefore, these proteins may provide a salvage pathway for dissociated tubulin heterodimers and so rescue cells from the deleterious effects of free β-tubulin.

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Masocha, Willias. « Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain : Studies in Animal Models ». Pain Research and Management 2018 (25 juillet 2018) : 1–9. http://dx.doi.org/10.1155/2018/5234943.

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There is a scarcity of drugs to either prevent or properly manage chemotherapy-induced neuropathic pain (CINP). Cannabis or cannabinoids have been reported to improve pain measures in patients with neuropathic pain. For this review, a search was done in PubMed for papers that examined the expression of and/or evaluated the use of cannabinoids or drugs that prevent or treat established CINP in a CB receptor-dependent manner in animal models. Twenty-eight articles that fulfilled the inclusion and exclusion criteria established were analysed. Studies suggest there is a specific deficiency of endocannabinoids in the periphery during CINP. Inhibitors of FAAH and MGL, enzymes that degrade the endocannabinoids, CB receptor agonists, desipramine, and coadministered indomethacin plus minocycline were found to either prevent the development and/or attenuate established CINP in a CB receptor-dependent manner. The studies analysed suggest that targeting the endocannabinoid system for prevention and treatment of CINP is a plausible therapeutic option. Almost 90% of the studies on animal models of CINP analysed utilised male rodents. Taking into consideration clinical and experimental findings that show gender differences in the mechanisms involved in pain including CINP and in response to analgesics, it is imperative that future studies on CINP utilise more female models.

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Hoyt, M. Andrew, Jennifer P. Macke, B. Tibor Roberts et John R. Geiser. « Saccharomyces cerevisiae PAC2 Functions With CIN1, 2 and 4 in a Pathway Leading to Normal Microtubule Stability ». Genetics 146, n^o 3 (1 juillet 1997) : 849–57. http://dx.doi.org/10.1093/genetics/146.3.849.

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The products of the Saccharomyces cerevisiae CIN1, CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function. In this article, we demonstrate that the product of PAC2 also functions in this pathway. PAC2 deletion mutants displayed phenotypes and genetic interactions similar to those caused by cin1Δ, cin2Δ and cin4Δ. These include cold-sensitive microtubule structures and sensitivity to the microtubule depolymerizing agent benomyl. Involvement in a common functional pathway is indicated by the observation that all double mutant combinations are viable and no more affected than any single mutant. In addition, extra copies of CIN1 were found to suppress the benomyl sensitivity of pac2Δ, cin2Δ and cin4Δ, but not that caused by other mutations that affect microtubule function. Cin1p and Pac2p were found to be related in sequence to mammalian proteins that aid in the folding of β-tubulin into an assembly-competent state. Alleles of CIN1 were identified that could suppress the benomyl sensitivity of cin4-4 in a highly specific fashion. Our findings suggest that the guanine nucleotide-binding Cin4p interacts with Cin1p and regulates its tubulin folding activity.

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Son, Dang Bao, Woosik Choi, Mingu Kim, Eun Jin Go, Dabeen Jeong, Chul-Kyu Park, Yong Ho Kim, Hanki Lee et Joo-Won Suh. « Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model ». Cells 10, n^o 3 (4 mars 2021) : 547. http://dx.doi.org/10.3390/cells10030547.

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Chemotherapy-induced neuropathic pain (CINP) is a severe adverse effect of platinum- and taxane-derived anticancer drugs. The pathophysiology of CINP includes damage to neuronal networks and dysregulation of signal transduction due to abnormal Ca2+ levels. Therefore, methods that aid the recovery of neuronal networks could represent a potential treatment for CINP. We developed a mouse model of paclitaxel-induced peripheral neuropathy, representing CINP, to examine whether intrathecal injection of decursin could be effective in treating CINP. We found that decursin reduced capsaicin-induced intracellular Ca2+ levels in F11 cells and stimulated neurite outgrowth in a concentration-dependent manner. Decursin directly reduced mechanical allodynia, and this improvement was even greater with a higher frequency of injections. Subsequently, we investigated whether decursin interacts with the transient receptor potential vanilloid 1 (TRPV1). The web server SwissTargetPrediction predicted that TRPV1 is one of the target proteins that may enable the effective treatment of CINP. Furthermore, we discovered that decursin acts as a TRPV1 antagonist. Therefore, we demonstrated that decursin may be an important compound for the treatment of paclitaxel-induced neuropathic pain that functions via TRPV1 inhibition and recovery of damaged neuronal networks.

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Lin, A. Y., et N. B. Kouzminova. « Predictors of oxaliplatin-induced peripheral neuropathy in patients with advanced colorectal cancer (CRC). » Journal of Clinical Oncology 29, n^o 4_suppl (1 février 2011) : 619. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.619.

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619 Background: Chemotherapy-induced neuropathy (CINP) is one of the major dose-limiting toxicities of oxaliplatin. The purpose of this study was to identify early predictors of CIPN and investigate the feasibility of using nerve conduction studies (NCS) to monitor CINP. Methods: Under IRB-approved protocol, we systematically examined patient-reported symptoms, neurological tests and bilateral NCS of the peroneal, superficial peroneal and sural nerves every 3 weeks before each dose of oxaliplatin (75-130 mg/m2) in 12 CRC patients receiving 8 to 13 cycles of XELOX. The severity of neuropathy was graded by the NCI Common Toxicity Criteria (CTC v.4.0) and the Oxaliplatin-Specific Neurotoxicity Scale (OSNS). Results: At the end of chemotherapy three of 12 patients developed peripheral sensory neuropathy CTC grade 3, five had grade 2, and four had grade 1 (3 of them had no self-reported symptoms with loss of Achilles tendon reflexes). At the eighth cycle test only 4 patients experienced CTC grade 2 criteria, but 7 of 12 patients had paresthesias persisting between the cycles of chemotherapy (OSNS grade 2 or higher). Development of grade 2 CINP by CTC or OSNS criteria by the eights cycle of chemotherapy was not associated with the total dose of oxaliplatin received (ANOVA p = 0.86 and 0.78 accordingly), but was significantly associated with administration of concomitant medication (Spearman correlation = 0.62, p = 0.03 for OSNS and 0.6, p = 0.04 for CTC grade 2 CINP). Presence of grade 2 or higher sensory neuropathy before the 8th cycle of oxaliplatin was significantly associated with development of grade 3 CINP by the time of chemotherapy completion (Spearman correlation = 0.8, p = 0.001). The maximal CINP grade that patients have reached during chemotherapy was also significantly associated with concomitant medication use (Spearman correlation = 0.76, p = 0.004). Conclusions: Concomitant administration of medications was the only factor significantly associated with severity of CINP in our study cohort. Further study is needed to verify if it is associated with altered bioavailability of oxaliplatin. No significant financial relationships to disclose.

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Meng, Xianze, Qing Sun, Ting Miao, Qiling Liu, Hongxian Ren et Yinglu Feng. « Involvement of spinal cannabinoid receptor type 2 in the analgesia effect of hyperbaric oxygen treatment on paclitaxel-induced neuropathic pain ». Undersea and Hyperbaric Medicine 49, n^o 2 (1 janvier 2022) : 65–75. http://dx.doi.org/10.22462/01.02.2022.6.

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Background: Chemotherapy-induced neuropathic pain (CINP) is intractable, and spinal cannabinoid receptors (CBRs) are potential therapeutic targets for CINP. Previous studies demonstrated that hyperbaric oxygen (HBO2) may contribute in alleviating specific peripheral neuropathic pain. However, neither CINP nor CBR have been clarified. We hypothesized that HBO2 is capable of alleviating CINP, and the effect could be explained by the activation of spinal CBRs. Methods: A series of paclitaxel-induced CINP models were established on male Sprague-Dawley rats. Then HBO2 treatment was administered for seven consecutive days at 2.5 atmospheres absolute. Two groups were treated with AM251 (an antagonist of CBR type-1, CBR1) or AM630 (an antagonist of CBR type-2, CBR2) respectively 30 minutes before each HBO2 treatment. The mechanical withdrawal threshold was assessed before, during and at two weeks after HBO2 treatment. Lumbar spinal cords were collected for Western blot analysis of CBR1, CBR2, GFAP and CD11b, and ELISA analysis of proinflammatory cytokines IL-1β and TNF-α. Results: A mechanical allodynia was successfully exhibited and the spinal GFAP, CD11b, IL-1β and TNF-α significantly increased after the modeling, and these effects could be further reversed by HBO2 treatment, which could be blocked by AM630, other than AM251. Conclusions: HBO2 treatment can alleviate paclitaxel-induced neuropathic pain, and be mediated by CBR2. Spinal glial cells and proinflammatory cytokines are involved in this process.

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Kim, Yeo Ok, Ji A. Song, Woong Mo Kim et Myung Ha Yoon. « Antiallodynic Effect of Intrathecal Korean Red Ginseng in Cisplatin-Induced Neuropathic Pain Rats ». Pharmacology 105, n^o 3-4 (2 octobre 2019) : 173–80. http://dx.doi.org/10.1159/000503259.

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Background: Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryptamine (5-HT)7 receptor at the spinal level. Methods: CINP was evoked by intraperitoneal injection of cisplatin in male Sprague-Dawley rats. After examining the effects of intrathecally administered KRG on CINP, 5-HT receptor antagonist (dihydroergocristine [DHE]) was pretreated to determine the involvement of 5-HT receptor. In addition, intrathecal 5-HT7 receptor antagonist (SB269970) was administered to define the role of 5-HT7 receptor on the effect of KRG. 5-HT7 receptor mRNA expression levels and 5-HT concentrations were examined in the spinal cord. Results: Intrathecally administered KRG produced a limited, but a dose-dependent, antiallodynic effect. Intrathecally administered DHE antagonized the antiallodynia caused by KRG. Furthermore, intrathecal SB269970 also reversed the effect of KRG. No changes in 5-HT7 receptor mRNA expression were seen in the dorsal horn of the spinal cord after cisplatin injection. After injecting cisplatin, 5-HT levels were decreased in the spinal cord, whereas those of 5-HT were increased by intrathecal KRG. Conclusions: Intrathecally administered KRG decreased CINP. In addition, spinal 5-HT7 receptors contributed to the antiallodynic effect of KRG.

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&NA;. « News from the XXIII CINP Congress ». Inpharma Weekly &NA;, n^o 1351 (août 2002) : 14–15. http://dx.doi.org/10.2165/00128413-200213510-00035.

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Gewandter, Jennifer S., Charles E. Heckler, Katie Devine, Supriya Gupta Mohile, Oxana Palesh, Joseph Roscoe, Gary R. Morrow, Martin Joseph Bury et Andrew Jacobs. « Pain, sleep disturbance, and fatigue symptom cluster in patients suffering from chronic chemotherapy-induced neuropathic pain (CINP). » Journal of Clinical Oncology 30, n^o 15_suppl (20 mai 2012) : 9113. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9113.

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9113 Background: Various symptom cluster combinations of pain, fatigue, sleep disturbance (SD), and depression have been identified in cancer patients. The presence of symptom clusters has not been assessed in patients with persistent CINP. This exploratory analysis aimed to determine which symptoms statistically clustered with pain in cancer survivors with CINP. Methods: The University of Rochester Cancer Center Community Clinical Oncology Program recruited 461 patients with CINP > 4 (on a 0-10 scale) who had completed chemotherapy (median 7 months ago) for a pain intervention trial. At baseline, groups of highly associated symptoms that included pain were identified empirically using factor and cluster analyses of the 11 symptoms in the University of Rochester Symptom Inventory plus the Hospital Anxiety and Depression Scale (HADS) scores. To investigate if associated symptoms track together over time, multiple linear regression (MLR) analysis was performed using changes in symptom severity between baseline and week 6, controlling for gender, age, education, race, and marital status. Results: Subjects were 88% white and 71% female, and on average 61 years old. Mean (standard deviation) baseline pain, fatigue, and SD were 5.7 (2.8), 5.0 (2.7), and 4.2 (3.1), respectively; 26% of subjects had borderline or abnormal HADS scores. Factor analysis identified 3 factors that accounted for 88% of the variance. One factor included pain, fatigue, SD, but not HADS, and accounted for 37% of the variance. Variable clustering also identified pain, SD, and fatigue as 1 symptom cluster. Changes in severity of SD and fatigue (p < 0.0001), but not HADS, were associated with changes in pain (adjusted R2 = 0.168) in MLR analysis. Conclusions: Pain, fatigue, and SD were identified as a symptom cluster by factor and cluster analyses, and were found to track together over time by MLR. Since these data suggest that pain is associated with sleep quality and fatigue in patients with persistent CINP, targeting one of these symptoms may lead to reductions in the others. Future research should investigate interventions that target pain, fatigue, and SD concurrently in cancer survivors suffering from CINP.

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Liu, Yan-Wen, Ying-Jung Chen, Yen-Hao Chen et Ming-Yen Tsai. « Therapeutic Efficacy of Traditional Chinese Medicine Syndrome-Based Formulae to Neuropathic Pain Caused by Chemotherapy ». Integrative Cancer Therapies 21 (janvier 2022) : 153473542211210. http://dx.doi.org/10.1177/15347354221121095.

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Objective: Chemotherapy-induced neuropathic pain (CINP) is a troublesome complication of anti-cancer treatment. The aim of this retrospective study was to investigate the effectiveness of classic Chinese herbal formulae (CHF) Huang Qi Gui Zhi Wu Wu Tang (HQGZWWT) and Dang Gui Si Ni Tang (DGSNT) in the treatment of CINP. Materials and Methods: Douleur Neuropathique 4 (DN4) and Functional Assessment of Cancer Therapy-General (FACT-G) questionnaires were rated at baseline and after 3-monthly CHF treatment. Results: By searching through our medical records of all the CIPN patients from 2018 to 2019, we identified and enrolled 37 patients with Deficiency-Cold syndrome in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed or intolerable. At the third month evaluation with the DN4 questionnaire, 13 patients had symptomatic remission, 15 patients remained stable, and 9 patients had no response to CHF. The 3-month mean DN4 score was significantly higher than that at the baseline ( P < .001). After CHF treatment, significant differences in quality of life were noted in the physical, social, emotional, and functional well-being subscales, and in the total score, of the FACT-G ( P < .001). No adverse events or instances of disease progression were observed. Conclusions: The results of our small study are the first in the literature to show the clinical effectiveness of CHF for CINP. Combination of HQGZWWT and DGSNT is well tolerated and may offer the possibility to ameliorate CINP more than conventional care can. It merits further investigation.

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Thèses sur le sujet "CINP"

DONVITO, GIULIA. « PHARMACOLOGICAL EFFECTS OF PALMITOYLETHANOLAMIDE (PEA) IN DIFFERENT ANIMAL MODELS OF NEUROPATHIC PAIN ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/101790.

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Neuropathic pain is defined by the International Association for the Study of Pain (IASP) as pain that arises as a direct consequence of a lesion or disease affecting the somatosensory system. Neuropathic pain is often poorly alleviated by first-, and second-line medications recommended by IASP due to lack of efficacy and/or dose-limiting side-effects. Hence, there is an urgent need to develop novel mechanism-based therapeutic agents that are highly efficacious and well tolerated to improve relief of neuropathic pain. Palmitoylethanolamide (PEA) is the parent molecule of ALIAmides (Autacoid Local Injury Antagonism Amides), a group of endogenous fatty acid derivatives sharing anti-inflammatory and antinociceptive effects with the endocannabinoid family mainly through the down-modulation of local mast cell degranulation. Several evidences in literature show the antinociceptive effect of PEA in different animal models of pain, such as spinal cord injury, chronic constriction injury of the sciatic nerve, carrageenan-induced acute inflammation, and complete Freund’s adjuvant-induced chronic inflammation. Based on these fundings, the aim of this study is to further explore the therapeutic potentiality of PEA in resolving painful states in three very common forms of neuropathic pain in human associated to osteoarthritis, diabetes, and chemotherapy. Osteoarthritis (OA) is the most common chronic joint disease characterized by a progressive destruction of cartilage, resulting in pain, and loss of articular function. The monosodium iodoacetate (MIA) rat model of OA was used to investigate the effects of PEA. Under a chronic treatment regiment, PEA was able to completely abolish knee swelling and thermal hyperalgesia, as index of inflammation. Moreover, treatment with PEA resulted in a significant relief of mechanical allodynia, as index of neuropathic pain. Futhermore, PEA treatment completely restored locomotor functionality, and is also able to preserve cartilage from damage. Diabetes mellitus is a metabolic syndrome today affecting 382 million people. One of the most disabling long-term complications of diabetes is diabetic neuropathy. The well established streptozotocin (STZ)-induced mice model of type 1 diabetes was emploied to explore the antinociceptive effect of PEA in diabetic neurophaty. PEA relieved mechanical allodynia, counteracted nerve growth factor deficit, improved insulin level, preserved Langherans islet morphology reducing the development of insulitis in diabetic mice. Chemotherapy-induced neuropathic pain (CINP) is another common form of neurophatic pain, affecting up to 90% of patients. The effect of PEA in paclitaxel model of CINP, one of the most common used antineoplastic drugs in clinic, was investigated. Preliminary results show that PEA is able to evoke a total antiallodynic effect in CINP model, after acute administration. The results of this thesis show the pharmacological effect of PEA to relieve neuropathic pain associated to osteoarthritis, diabetes, and chemotherapy, three very common diseases in human, that lack a resolutive, and effective treatment. These findings allow us to suggest a therapeutic use of PEA in clinic.

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BADRIKIAN, LAURENCE. « Neoplasies cervicales intraepitheliales et microcarcinome du col : analyse de 93 vaporisations de cin2 et cin3 et de 52 conisations ». Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13082.

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OLIVEIRA, ROBERTO OTO LOUREIRO DE. « CARAVELAS CINE CLUB : THE CINE IN THE SOUTH OF BAHIA ». PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23903@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O presente trabalho faz uma análise sobre os filmes produzidos pelo Cineclube Caravelas, localizado no município de Caravelas, sul da Bahia. Pretendemos, por meio desta análise, propor uma reflexão sobre a apropriação dos meios audiovisuais de produção por grupos comunitários de comunicação. Por este caminho, investigamos as dinâmicas históricas do município de Caravelas, a fim de entendermos o contexto político, social e cultural de surgimento do Cineclube Caravelas. No rastro dessa discussão, buscamos uma releitura dos espaços de legitimação e representação sociais num âmbito comunitário, possibilitados pela produção e veiculação de filmes por grupos à margem dos grandes centros de produção audiovisual.
This paper analyses the movie production of the Caravelas Cine Club, situated in the city of Caravelas, in the south of Bahia. Through this analysis we intend to propose a reflection on the appropriation of audiovisual production media by communication community groups. By doing so, we investigated the historic dynamic of Caravelas so as to understand the political, social and cultural context of the establishment of the Caravelas Cine Club. Following this debate, we sought a re-interpretation of the legitimating and social representation spaces in a community environment, made possible by the production and broadcasting of movies by groups acting on the margins of the big centers of audiovisual production.

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Tonini, Arnaldo <1992&gt. « Vino in Cina ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/11844.

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La tesi tocca la tematica del vino in tutte le sue sfaccettature con focus sulla Cina. Temi principali trattati sono: storia del vino cinese, produzione regione per regione, import, profilo consumatore cinese, metodi di autenticazione, controllo qualità, e-commerce cinese con specifica vino

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Vásquez, Landa Claudia Carolina. « Valores formales del cine tradicional del Siglo XX, caso Ex Cine Metro ». Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/655992.

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El trabajo de investigación tiene como finalidad mostrar al lector el valor formal existente en la arquitectura y diseño del Cine Tradicional del Siglo XX. Usando como caso de estudio el Ex Cine Metro, ubicado en el Centro Histórico de Lima. Para ello, se define el valor formal y se analiza desde 3 diferentes escalas: Escala urbana, escala del edificio y escala de detalles. Así mismo, se estudia como el contexto del inmueble puede afectar este valor formal, tomando como referencia la ubicación el Centro Histórico de Lima, área protegida por la UNESCO. De igual manera, se realiza una comparación con otros casos de estudio: Cine Teatro Colón, Cine Metropolitan y Cine Central para notar las diferencias o similitudes existentes y entender a qué se deben estas mismas. El trabajo se centra en descubrir el valor formal del inmueble mencionado, con el fin de concientizar sobre su importancia y reflexionar sobre qué se debería de mejorar para que se encuentre en óptimas condiciones.
The purpose of the research work is to show the reader the formal value existing in the architecture and design of the Traditional Cinema of the 20th century. Using as a case study the Ex Cine Metro, located in the Historic Center of Lima. To do this, the formal value is defined and analyzed from 3 different scales: urban scale, building scale and scale of details. Likewise, it is studied how the context of the property can affect this formal value, taking as a reference the location of the Historic Center of Lima, an area protected by UNESCO. In the same way, a comparison is made with other case studies: Cinema Theatre Colón, Cinema Metropolitan and Cinema Central to note the differences or existing similarities and understand what they are due to. The work focuses on discovering the formal value of the aforementioned property, in order to raise awareness about its importance and propose what should be improved so that it is sought in optimal conditions.
Trabajo de investigación

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Rinaldi, Serena <1992&gt. « La figura del leader in Cina e le nuove riforme di politica estera che regolano i rapporti tra Cina e Stati Uniti, Cina e Corea e Cina e Giappone ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/10761.

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Partendo dalla nascita della figura del leader in Cina, nella mia tesi, ho preso in esame la figura del dirigente all'interno dell'ordinamento giuridico cinese passando poi ad esaminare la situazione attuale. Negli ultimi capitoli, infatti, ho spostato la mia attenzione sul nuovo presidente analizzandolo sia come figura individuale sia attraverso le sue decisioni in campo internazionale. L'ultimo capitolo, in particolare, prenderà in esame i rapporti tra la Cina ed altri grandi paesi internazionali in campo di politica estera.

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Mota, Joana Isabel Marques. « Investigação fundo foto cine ». Master's thesis, Instituto Politécnico de Tomar, 2013. http://hdl.handle.net/10400.26/5770.

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O Projecto de Investigação incide no estudo do fundo fotográfico Foto Cine, tendo particular interesse pelos negativos em acetato de celulose. Este estudo tem como objectivo principal mostrar as várias etapas que constituem o trabalho do conservador de espécies fotográficas, nomeadamente na avaliação do estado de conservação, delineação de uma proposta de tratamento, e intervenção. Estas etapas resultam da conjugação de uma série de competências fundamentais ao exercício da actividade de conservação, como sejam a identificação das deteriorações presentes, a avaliação de dados recolhidos junto das entidades detentoras e, a partir da interpretação desses dados, apontar quais os possíveis tratamentos de conservação exequíveis tendo por base toda a investigação presente na literatura científica da especialidade. Os tópicos que se pretendem abordar neste projecto de investigação são: Introdução ao processo fotográfico em estudo e ao material usado como suporte (acetato de celulose); Breve história do fundo e sua contextualização histórica; Estudo pormenorizado das condições ambientais e de acondicionamento em que o fundo se encontra na actualidade; Análise do estado de conservação das espécies fotográficas, deteriorações encontradas, e tentativa de explicar quais as possíveis causas da sua ocorrência, tendo em conta o seu percurso; Apresentação de uma proposta de intervenção de Stripping, com os respectivos benefícios e custos.

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Ruiz, Vallejos Fernando. « Cine, educación y valores ». Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/117667.

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Samuel, Cueva Yauri Angello, et Carpio Pefaure Ruben. « Cine Digital-AV46-201601 ». Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/631947.

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Cine Digital es un curso de especialidad en la carrera de Comunicación Audiovisual y Medios Interactivos de carácter teórico - práctico dirigido a los estudiantes de noveno ciclo que busca desarrollar las competencias generales de Comunicación Escrita y Comunicación Oral y las competencias específicas de Construcción de un Relato y Técnica y Tecnología.Un relato cinematográfico dice más a través de lo que muestra que a través de los diálogos de los actores. Este curso está orientado a la enseñanza de herramientas para la construcción de un relato cinematográfico sólido. Al finalizar el curso podrás crear atmósferas visuales y plantear un diseño a cada uno de los proyectos audiovisuales a los que te enfrentes. Asimismo te otorgará herramientas que te permitirán insertarte en un rodaje con características profesionales.

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Samuel, Cueva Yauri Angello, et Anchi Leon Lino Jose. « Cine Digital-AV46-201602 ». Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/631948.

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Livres sur le sujet "CINP"

Ban, Thomas A., et Hanns Hippius, dir. Thirty Years CINP. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9.

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A, Ban Thomas, Healy David MRC Psych et Shorter Edward, dir. The rise of psychopharmacology and the story of CINP. Budapest : Animula, 1998.

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A, Ban Thomas, Healy David et Shorter Edward, dir. The triumph of psychopharmacology and the story of CINP. Budapest : Animula Publishing House, 2000.

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A, Ban Thomas, et Hippius Hanns, dir. Thirty years CINP : A brief history of the Collegium Internationale Neuro-Psychopharmacologicum. Berlin : Springer-Verlag, 1988.

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Cina Cina. Lecce : P. Manni, 1985.

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cing, cing, dir. cing cing. cing cing : cing cing the story, 2000.

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Cine, cine?, cine ! : La memoria vencida. Panamá : Ediciones Fotograma, 2009.

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Cine español actual. Madrid : Ediciones JC, 2001.

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Onghokham. Anti Cina, kapitalisme Cina, dan gerakan Cina : Sejarah etnis Cina di Indonesia. Depok : Komunitas Bambu, 2008.

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Guerra, Samuel Larson. Análisis de publicaciones periódicas sobre cine : Nuevo cine, Cine club, Otro cine, Octubre. [Mexico City, Mexico] : Cineteca Nacional, Departamento de Documentación e Investigación, 1986.

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Chapitres de livres sur le sujet "CINP"

Ban, Thomas A., et Hanns Hippius. « Introduction ». Dans Thirty Years CINP, 3–4. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_1.

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Hippius, H. « The 9th Congress — Paris 1974 ». Dans Thirty Years CINP, 30–33. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_10.

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Deniker, P. « The 10th Congress — Quebec 1976 ». Dans Thirty Years CINP, 34–36. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_11.

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Hollister, L. E. « The 11th Congress — Vienna 1978 ». Dans Thirty Years CINP, 37–41. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_12.

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Carlsson, A. « The 12th Congress — Gothenburg 1980 ». Dans Thirty Years CINP, 42–43. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_13.

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Janssen, P. « The 13th Congress — Jerusalem 1982 ». Dans Thirty Years CINP, 44–48. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_14.

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Kielholz, P. « The 14th Congress — Florence 1984 ». Dans Thirty Years CINP, 49–50. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_15.

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Wittenborn, J. R. « The 15th Congress — San Juan 1986 ». Dans Thirty Years CINP, 51–55. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_16.

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Bunney, W. E. « The 16th Congress — Munich 1988 ». Dans Thirty Years CINP, 56–57. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_17.

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Coppen, A. « Towards the 17th Congress — Kyoto 1990 ». Dans Thirty Years CINP, 58–59. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73956-9_18.

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Actes de conférences sur le sujet "CINP"

Borges, Isabella Sabião, João Victor Aguiar Moreira, Eustaquio Costa Damasceno Junior, Alencar Pereira dos Santos, Gabriela Tomás Alves, Leonardo Peixoto Garcia, Maria Fernanda Prado Rosa et al. « Chronic inflammatory demyelinating polyradiculoneuropathy induced by paclitaxel ». Dans XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.413.

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Background: Peripheral neuropathies in cancer are most often due to neurotoxic chemotherapeutic agents. Approximately 30% of patients receiving neurotoxic chemotherapy (CTX) will suffer from chemotherapy-induced peripheral neuropathy (CIPN). Paclitaxel is an extremely effective chemotherapeutic agent for the treatment of breast, ovarian, and lung cancer. However, paclitaxel-induced peripheral neuropathy occurs in 59-87% of patients who receive this drug. Paclitaxel is an anti-tubulin drug that causes microtubule stabilization, resulting in distal axonal degeneration, secondary demyelination and nerve fiber loss. Case: We present a case of a 68-year-old female patient with history of breast cancer who presented sensorial ataxia and progressive muscle weakness two months after starting CTX with paclitaxel. The physical examination showed tetraparesis with proximal predominance, areflexia, severe hypopalesthesia and postural instability. Electroneuromyography showed the existence of asymmetric demyelinating polyradiculoneuropathy, with conduction block and temporal dispersion in practically all evaluated nerves. The cerebrospinal fluid confirmed the albumin-cytological dissociation. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) was confirmed and patient underwent monthly treatment with methylprednisolone with good response. Discussion: Evidences has implicated neuroinflammation in the development of PIPN. While most CTX drugs do not cross the blood-brain-barrier, they readily penetrate the blood-nerve-barrier and bind to and accumulate in dorsal root ganglia and peripheral axons. CTX can induce neuroinflammation through activation of immune and immune- like glial cells. In fact, immune cells (e.g., macrophages, lymphocytes) and glial cells (e.g., Schwann cells) in the peripheral nervous system play important role in the induction and maintenance of neuropathy. Conclusion: CIDP should be included in the spectrum of CIPN.

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Inesi, Thomas. « Cino ». Dans ACM SIGGRAPH 99 Electronic art and animation catalog. New York, New York, USA : ACM Press, 1999. http://dx.doi.org/10.1145/312379.312880.

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Piedimonte, Sabrina, Nathaniel Jembere, Kyle Tsang, Julia Gao et Rachel Kupets. « EP184/#40 Defining the longitudinal risk of CIN3+ in patients with less than CIN2 colposcopy following index high grade cytology ». Dans IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.275.

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Feldtkeller, Jakob, Jan Richter-Brockmann, Pascal Sasdrich et Tim Güneysu. « CINI MINIS ». Dans CCS '22 : 2022 ACM SIGSAC Conference on Computer and Communications Security. New York, NY, USA : ACM, 2022. http://dx.doi.org/10.1145/3548606.3560614.

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Peihua Qiu, Yong Xiang, Yongsheng Ding, Demin Li et Lipo Wang. « Preface CISP 2011 ». Dans 2011 4th International Congress on Image and Signal Processing (CISP 2011). IEEE, 2011. http://dx.doi.org/10.1109/cisp.2011.6100658.

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« Reviewers CISP 2011 ». Dans 2011 4th International Congress on Image and Signal Processing (CISP 2011). IEEE, 2011. http://dx.doi.org/10.1109/cisp.2011.6100660.

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« CISP 2009 Preface ». Dans 2009 2nd International Congress on Image and Signal Processing (CISP). IEEE, 2009. http://dx.doi.org/10.1109/cisp.2009.5303538.

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« CISP 2009 Committees ». Dans 2009 2nd International Congress on Image and Signal Processing (CISP). IEEE, 2009. http://dx.doi.org/10.1109/cisp.2009.5303633.

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« CISP 2009 Reviewers ». Dans 2009 2nd International Congress on Image and Signal Processing (CISP). IEEE, 2009. http://dx.doi.org/10.1109/cisp.2009.5303782.

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« Reviewers : CISP 2010 ». Dans 2010 3rd International Congress on Image and Signal Processing (CISP). IEEE, 2010. http://dx.doi.org/10.1109/cisp.2010.5646796.

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Rapports d'organisations sur le sujet "CINP"

van de Sande, Anna, Malika Kengsakul, Margot Koeneman, Marta Jozwiak, Cornelis Gerestein, Arnold-Jan Kruse, Edith van Esch et al. Imiquimod in cervical dysplasia : a review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, novembre 2022. http://dx.doi.org/10.37766/inplasy2022.11.0046.

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Review question / Objective: To determine the efficacy of topical imiquimod in treatment of high-grade CIN (defined as regression CIN 1 or less), and to determine the clearance rate of high-risk human papillomavirus (hr-HPV), compared to surgical treatment and placebo. Condition being studied: Women with an untreated, histologically proven, CIN2-3 lesion or women who were persistent high-risk HPV positive. Eligibility criteria: Studies that evaluated the efficacy of imiquimod treatment in intraepithelial lesions or malignancy of other organs, and studies published as conference abstract, narrative review, editorial, letter, or short communication were excluded.

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Schilling, Duane T. Assessment of CINC Authorizations to CINC Requirements (ACAR) (Follow-On). Fort Belvoir, VA : Defense Technical Information Center, mars 2001. http://dx.doi.org/10.21236/ada411947.

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Shinn, Neal D. CINT 2020 Strategic Plan. Office of Scientific and Technical Information (OSTI), décembre 2014. http://dx.doi.org/10.2172/1173197.

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Rondinone, Adam. CINT 2026 Strategic Plan. Office of Scientific and Technical Information (OSTI), février 2021. http://dx.doi.org/10.2172/1764870.

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Henzlova, Daniela, Howard O. Menlove, Stephen J. Tobin, Robert M. Zedric, Carlos D. Rael, Isaac P. Martinez et Holly R. Trellue. Task 1 : CIPN in ROK. Office of Scientific and Technical Information (OSTI), septembre 2013. http://dx.doi.org/10.2172/1095214.

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Beecher, Cathy Jo. CINT Monthly News : February 2017. Office of Scientific and Technical Information (OSTI), février 2017. http://dx.doi.org/10.2172/1344347.

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Pietrass, Tanja. MPA CINT PPD-4 Search. Office of Scientific and Technical Information (OSTI), juillet 2019. http://dx.doi.org/10.2172/1544655.

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Martínez Parra, Marc. El vulcanismo en el cine. Ilustre Colegio Oficial de Geólogos, octobre 2021. http://dx.doi.org/10.21028/mmp.2021.10.06.

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Como recurso argumental o temático, o bien como soporte, el cine ha empleado conceptos de la vulcanología, desarrollando historias enmarcadas, en diversos géneros cinematográficos, especialmente el cine de catástrofes, de aventuras y el documental, con filmes basados en sucesos reales o bien ficticios, como las acaecidos en las ciudades de Pompeya y Dante’s Peak, respectivamente. Son filmes en lo que los efectos especiales tienen gran importancia. También el género documental, tanto en noticiarios como en largometrajes, a causa de la espectacularidad de las imágenes de la naturaleza más primigenia, ha tenido en el vulcanismo un imán en cuanto a interés del público.

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Allen, J., P. Leach et R. Hedberg. CIP Transport Protocols. RFC Editor, août 1999. http://dx.doi.org/10.17487/rfc2653.

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Wixom, Ryan R. CINT Monthly Report for May 2017. Office of Scientific and Technical Information (OSTI), mai 2017. http://dx.doi.org/10.2172/1367423.

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