Articles de revues : « CIM-11 »

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Pull, Charles B. « DSM-5 et CIM-11 ». Annales Médico-psychologiques, revue psychiatrique 172, n^o 8 (octobre 2014) : 677–80. http://dx.doi.org/10.1016/j.amp.2014.08.016.

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Stona, A. C., C. Kogan, J. Keeley, S. Evans et G. Reed. « Étude de terrain sur les troubles de l’alimentation et des conduites alimentaires dans le cadre du développement de la CIM 11 ». European Psychiatry 29, S3 (novembre 2014) : 568. http://dx.doi.org/10.1016/j.eurpsy.2014.09.249.

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ContexteDans le cadre du développement de la classification internationale des maladies (CIM-11), les groupes de travail ont développé des propositions avec pour objectif d’améliorer l’utilité clinique de la classification. Ces propositions sont testées via la plateforme internet « Réseau Mondial de Pratique Clinique (RMPC) » permettant de conduire à des études cliniques électroniques dans les langues officielles de l’OMS, dont le français. Cette étude s’intéresse aux catégories diagnostiques des troubles de l’alimentation et des conduites alimentaires (TCA). Des nouveaux diagnostics ont été proposés tels que le trouble d’hyperphagie et le trouble d’évitement et de restriction de l’apport alimentaire.Objectifs– évaluer l’impact des changements spécifiques des TCA entre la CIM-10 et la CIM-11 auprès des membres francophones du RMPC ;– évaluer la validité, l’utilité clinique des nouvelles propositions et l’accord inter-juges des participants.MéthodeÉtude mixte, internationale, conduite par internet auprès des membres francophones du RMPC.PopulationMembres du RMPC maîtrisant le français (environ 1000 professionnels) et exerçant une activité clinique.DéroulementLa population cible recevra un email d’invitation. Les participants seront amenés à lire deux vignettes puis à poser des diagnostics et à répondre à des questions complémentaires, en se basant sur la CIM-10 ou la CIM-11 qu’ils auront reçu de façon aléatoire.OutilsLes vignettes représenteront des cas cliniques réels et reflèteront les changements spécifiques entre la CIM-10 et la CIM-11. Elles seront ainsi présentées par pair (8 pairs possibles).AnalyseComparaisons :– interparticipants portant sur l’utilisation du système diagnostique (10 ou 11) et l’attribution du diagnostic en fonction des changements spécifiques ;– intra-participant sur l’évaluation des pairs de vignettes.Résultats attendusCette étude doit permettre d’évaluer les nouvelles propositions CIM en français, en tenant compte des spécificités culturelles et linguistiques de la francophonie.

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Fei, Kailun, Yundi Zhang, Yiting Dong, Liman Liman, Yiqi Li, Wenjing Yang, Jie Wang et Zhijie Wang. « Real-world burden and treatments of chemotherapy-induced myelosuppression among patients with extensive-stage small-cell lung cancer : A retrospective real-world study in China. » Journal of Clinical Oncology 42, n^o 16_suppl (1 juin 2024) : e20102-e20102. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e20102.

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e20102 Background: Chemotherapy-induced myelosuppression (CIM) is the major dose-limiting and severe complication for chemotherapy, particularly etoposide plus platinum-based therapy (EP), in patients with extensive-stage small-cell lung cancer (ES-SCLC). CIM adversely affects patient quality of life and imposes substantial economic burden. In China, there’s a scarcity of related studies, especially in large cohort. This study aims to summarize the burden and treatments of CIM in ES-SCLC patients using a nationally representative real-world database. Methods: Data were derived from 53 hospitals across 28 provinces, as part of the National Cancer Center (NCC) database. ES-SCLC patients receiving EP between 2018.1.1 and 2022.12.31 were included. CIM events, namely chemotherapy induced neutropenia (CIN), thrombocytopenia (CIT), and anemia (CRA) were identified based on laboratory tests and graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 5. Incidence, treatments and impact on hospitalization cost of CIM were described. Results: 7,505 patients were included, with an average age of 61.2 years (SD = 9.02) and an average of 5.0 chemotherapy cycles (SD = 2.01). The overall incidence of CIM was 91.95%, with grade 3-4 CIM occurring in 25.09% patients. Incidence of CIN, CIT, and CRA, were 44.74%, 39.20%, and 86.48%, respectively, with febrile neutropenia at 0.72%. Among patients with CIN, 90.89% patients used granulocyte colony stimulating factor (G-CSF), and 90.56% used it prophylactically. Among patients with CIT, 17.47% used recombinant human thrombopoietin (rhTPO) and 25.49% used recombinant human interleukin-11 (rhIL-11). Among patients with CRA, 10.26% used erythropoiesis-stimulating agent (ESA). Occurrence of grade 1-2 CIM and grade 3-4 CIM may increase 9.37% and 32.36% hospitalization cost per chemotherapy cycle, respectively (¥23,316.3 vs ¥21,318.2, ¥28,217.0 vs ¥21,318.2), compared to patients without any CIM. Conclusions: Incidence of CIM is notably high among ES-SCLC patients receiving EP, and treatments like G-CSF, rhTPO, rhIL-11 and ESA are widely used. Occurrence of CIM critically escalates hospitalization cost. Innovations to protect bone marrow from chemotherapy-induced damage are promising to alleviate the burden and benefit quality of life for ES-SCLC patients.[Table: see text]

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Bozinovic, I., et S. Guéant. « Conduite d'une étude d'impact de la transition CIM-10 vers CIM-11 et projet de déploiement ». Journal of Epidemiology and Population Health 72 (mars 2024) : 202222. http://dx.doi.org/10.1016/j.jeph.2024.202222.

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Wolfson, A. H., M. F. Brady, R. S. Mannel, Y. Lee, R. J. Futoran, D. Cohn, O. B. Ioffe et T. F. Rocereto. « A Gynecologic Oncology Group randomized trial of whole abdominal irradiation (WAI) vs cisplatin-ifosfamide+mesna (CIM) in optimally debulked stage I-IV carcinosarcoma (CS) of the uterus ». Journal of Clinical Oncology 24, n^o 18_suppl (20 juin 2006) : 5001. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5001.

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5001 Background: Besides initial surgery, there has been no established consensus regarding adjunctive therapy for optimally debulked patients with uterine CS. This study was designed to compare progression-free interval (PFI), overall survival (OS), toxicity, and failure patterns using WAI vs CIM chemotherapy for this uncommon group of female malignancies. Methods: Patients with stage I-IV disease, ≤ 1 cm residual tumor, and no extra-abdominal involvement were randomly assigned to either WAI (approximately 30 Gy followed by pelvic boost) or cisplatin 20 mg/m2/d × 4, ifosfamide 1.5 g/m2/d × 4 and mesna 120 mg/m2 loading dose, then 1.5 g/m2/d × 24 h, repeated q 3 weeks × 3 cycles. Results: 224 patients were enrolled, of whom 207 (WAI = 105; CIM = 102) were eligible. Patient demographics and characteristics were similar between arms. FIGO stage (both arms) was: I = 64 (31%); II = 26 (12%); III = 93 (45%); IV = 24 (11%). GI toxicity ≥ grade 2 occurred frequently and similarly (31%, both arms). CIM was associated with more ≥ grade 3 anemia (11% vs 1%) and neurotoxicity (9% vs 0%) compared to WAI. Two deaths were attributed to RT-induced hepatitis. Sites of first recurrence in WAI vs CIM among the 97 (47%) patients who relapsed were: vagina, 4 vs 10; pelvis, 12 vs 12; abdomen, 23 vs 14; lung, 13 vs 13; other, 13 vs 9. The estimated probability of recurring within 5 years is 55% (WAI) and 49% (CIM). Adjusting for stage, the recurrence rate was 28.5% lower for CIM patients relative to WAI patients (hazard ratio [HR]: 0.715, 95% confidence interval [CI]: 0.474–1.077, p = 0.108, 2-tail test). The estimated death rate for CIM is 32.8% lower relative to WAI (HR: 0.672, 95% CI: 0.458–.986, p = 0.042). Conclusion: Compared to WAI, adjuvant CIM reduces the recurrence rate and significantly prolongs OS in optimally debulked uterine CS patients; however, due to a high relapse rate and poor OS, the imperative for new adjuvant therapies remains. No significant financial relationships to disclose.

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Walji, N., A. Zachariah, C. Yap, S. A. Hussain, C. J. Poole, A. El-Modir, R. Ganesan et I. N. Fernando. « Carboplatin, ifosfamide, and mesna (CIM) for the treatment of gynecological carcinosarcoma ». Journal of Clinical Oncology 27, n^o 15_suppl (20 mai 2009) : e16539-e16539. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e16539.

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e16539 Background: A GOG trial comparing cisplatin/ifosfamide/mesna chemotherapy versus whole abdominal irradiation for FIGO stages I-IV carcinosarcoma (CS) showed an estimated median survival (MS) of 50 months for chemotherapy but high toxicity. This study investigates the efficacy and tolerability of a novel regimen using carboplatin AUC 5, ifosfamide 3 g/m2 and mesna 1 g/m2 (CIM) in both the adjuvant and metastatic setting. Methods: Retrospective analysis of women with CS treated from May 1997-May 2007 with CIM (group 1) versus other chemotherapy regimens (group 2). Toxicity was graded according to the Common Toxicity Criteria and MS estimated using the Kaplan-Meier method. Results: Of 51 eligible women (median age 71 years) 35 (69%) had stage 3 or 4 disease. 35/51 (69%) received chemotherapy; 2 with stage 1c disease received pelvic radiotherapy (pRT) alone whilst the remaining 14 were unfit for any treatment. Median follow-up for the treated patients is 45 months. 11/35 patients (31%) received CIM as first-line chemotherapy. Other regimens included: carboplatin (n = 14); carboplatin/paclitaxel (n = 3); carboplatin/epirubicin (n = 3); carboplatin/doxorubicin (n = 2); doxorubicin/ifosfamide (n = 1); cisplatin/ifosfamide (n = 1). 20/35 (57%) received adjuvant chemotherapy (AC) of which 8 received CIM; 11/20 patients also received adjuvant pRT. MS in the CIM AC group is 54.7 months compared to 37.4 months for other regimens. 3/8 patients (37.5%) in the CIM arm developed recurrent disease compared to 9/12 (75%) for other regimens. 4/16 patients received CIM as first- or second-line palliative chemotherapy. All patients responded of whom 2 achieved clinical and radiological complete response (CR). One woman subsequently relapsed and achieved a second CR with CIM. MS for all chemotherapy-treated patients is 54.7 months (group 1) versus 20.6 months (group 2) (p = 0.07). No patients in group 1 experienced any grade 3/4 toxicity and all patients completed the prescribed treatment. There were 2 unexpected treatment-related deaths in group 2, one of whom received carboplatin/paclitaxel and the other carboplatin/epirubicin. Conclusions: CIM appears to be efficacious and well tolerated in the treatment of CS and merits further investigation in clinical trials. No significant financial relationships to disclose.

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Yu, Qing-Qing, Heng Zhang, Yujin Guo, Baoqin Han et Pei Jiang. « The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis ». Oxidative Medicine and Cellular Longevity 2022 (9 mai 2022) : 1–29. http://dx.doi.org/10.1155/2022/7255497.

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Chemotherapy-induced intestinal mucositis (CIM) is a significant dose-limiting adverse reaction brought on by the cancer treatment. Multiple studies reported that reactive oxygen species (ROS) is rapidly produced during the initial stages of chemotherapy, when the drugs elicit direct damage to intestinal mucosal cells, which, in turn, results in necrosis, mitochondrial dysfunction, and ROS production. However, the mechanism behind the intestinal redox system-based induction of intestinal mucosal injury and necrosis of CIM is still undetermined. In this article, we summarized relevant information regarding the intestinal redox system, including the composition and regulation of redox enzymes, ROS generation, and its regulation in the intestine. We innovatively proposed the intestinal redox “Tai Chi” theory and revealed its significance in the pathogenesis of CIM. We also conducted an extensive review of the English language-based literatures involving oxidative stress (OS) and its involvement in the pathological mechanisms of CIM. From the date of inception till July 31, 2021, 51 related articles were selected. Based on our analysis of these articles, only five chemotherapeutic drugs, namely, MTX, 5-FU, cisplatin, CPT-11, and oxaliplatin were shown to trigger the ROS-based pathological mechanisms of CIM. We also discussed the redox system-mediated modulation of CIM pathogenesis via elaboration of the relationship between chemotherapeutic drugs and the redox system. It is our belief that this overview of the intestinal redox system and its role in CIM pathogenesis will greatly enhance research direction and improve CIM management in the future.

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Chams, Cyril, Ana Borda De Agua Reis, Chantal Berna et Marc R. Suter. « Douleurs chroniques liées au cancer : physiopathologie et classification CIM-11 ». Revue Médicale Suisse 18, n^o 787 (2022) : 1259–63. http://dx.doi.org/10.53738/revmed.2022.18.787.1259.

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Lorette, Adrien, et Juan-Pablo Lucchelli. « Présentation de la nouvelle Classification internationale des maladies (CIM-11) ». L'information psychiatrique 98, n^o 6 (1 juillet 2022) : 426–34. http://dx.doi.org/10.1684/ipe.2022.2437.

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Moeglin, Clotilde, et Othman Sentissi. « Appel à participation pour le développement de la CIM-11 ». Revue Médicale Suisse 10, n^o 421 (2014) : 626. http://dx.doi.org/10.53738/revmed.2014.10.421.0626.

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Bennetts, Shannon K., Amanda R. Cooklin, Sharinne Crawford, Fabrizio D’Esposito, Naomi J. Hackworth, Julie Green, Jan Matthews, Lyndall Strazdins, Stephen R. Zubrick et Jan M. Nicholson. « What Influences Parents’ Fear about Children’s Independent Mobility ? Evidence from a State-Wide Survey of Australian Parents ». American Journal of Health Promotion 32, n^o 3 (22 novembre 2017) : 667–76. http://dx.doi.org/10.1177/0890117117740442.

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Purpose: To identify factors associated with generalized and stranger-specific parental fear (PF) about children’s independent mobility (CIM), a critical aspect of physical activity. Design: Cross-sectional survey; random sampling frame, minimum quotas of fathers, rural residents. Setting: State of Victoria, Australia. Subjects: Parents of children aged 9 to 15 years (n = 1779), 71% response rate. Measures: Validated measures of PF and fear of strangers (FoS); parent, child, social, and environmental factors. Analysis: Unadjusted and adjusted linear regression stratified by child age (9-10; 11-13; 14-15). Results: Adjusted models explained a substantial proportion of variance across all age groups (PF: 33.6%-36.7%; FoS: 39.1%-44.0%). Perceived disapproval from others was consistently associated with both outcomes (PF: β =.11 to 23, p ≤ .05; FoS: β =.17-.21, p ≤ .001) as was parents’ perception of children’s competence to travel safely (PF: β = −.24 to −.11, p ≤ .05; FoS: β = −.16 to −.13, p ≤ .01). Factors associated with FoS included having a female child (β = −.21 to −.13, p ≤ .001), language other than English (β = .09 to.11, p ≤ .01), and low levels of parent education (β = −.14 to −08, p ≤ .05). Conclusion: The current study suggests that social norms, child competence, and perceptions about the benefits of CIM underpin PF. This evidence informs the development of interventions to reduce PF and promote CIM and children’s physical activity.

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Soomro, Abdul Wahab. « Evaluation of advanced cotton genotypes at the field conditions of different locations of Sindh and Balochistan ». International Journal of Cotton Research and Technology 3, n^o 1 (14 décembre 2021) : 15. https://doi.org/10.33865/ijcrt.003.01.0451.

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Thirty advanced candidate cotton lines were tested during two consecutively years (2019 and 2020) and at seven locations of Sindh and Baluchistan Provinces in national coordinated varietal trials (NCVT). The trials were conducted to evaluate promising line for seed cotton yield and fiber properties against standard check variety. The results revealed highly significant differences among the varieties during both the years. In 2019, on an average of seven locations, top ten high yielding varieties recorded were Rustam-11, GH-Sultan, Saim-102, CIM-775, Diamond-2, NIA-88, NIA-89, ASPL-710, IR-NIBGE-15 and CRIS-644 which given maximum seed cotton yield. In 2020, on an average of top ten high yielding varieties were GH-Sultan, CIM-775, NIA-88, Diamond-2, Cyto-535, Siam-102, FH-Anmol, Cyto-226, ASPL-710 and NIAB-512 which attained highest seed cotton yield. However, when the results of 2019 and 2020 were summed up, top ten high yielding varieties were GH-Sultan, CIM-775, Rustam-11, Diamond-2, NIA-88, Siam-102, Cyto-535, NIA-89, ASPL-710 and IR-NIBGE-15. It was noted from the present research that among top 10 high yielding varieties during both years, only six varieties (GH-Sultan, CIM-775, Diamond-2, NIA-88, Siam-102 and ASPL-710) were stable with yield performance due to the fact that these varieties keep their superiority in individual year (2019 and 2020) it is suggested that the top six high yielding varieties (GH-Sultan, CIM-775, Diamond-2, NIA-88, Siam-102 and ASPL-710) with stability in performance must be approved by the provincial seed council of Sindh and Balochistan to revive the cotton production of the provinces and not to waste/garbage this high yielding stuff.

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Morales Martinez, Elias David, et Thaís Regina Servidoni. « A influência do complexo industrial-militar na Política Externa dos Estados Unidos da América após os atentados do 11 de Setembro ». Carta Internacional 14, n^o 1 (21 mai 2019) : 127–52. http://dx.doi.org/10.21530/ci.v14n1.2019.866.

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O presente artigo analisa as influências do complexo industrial-militar (CIM) na tomadade decisões dos policymakers estadunidenses e o posterior aumento do orçamento militarno início do século XXI, a partir dos atentados terroristas de 11 de Setembro de 2001. Alémdisso, pretende-se discorrer sobre a legitimação da securitização da defesa e da consequenteadoção de uma política externa constantemente militarizada, justificada pela Guerra GlobalContra o Terror, a qual é subsidiada pelos trabalhos desenvolvidos por alguns think tanksespecíficos e que são financiados pelo CIM, sendo disseminadas as ideias securitizantes nosdiscursos dos principais stakeholders governamentais.

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Massimi, Luca, Emanuele Pravatà, Gianpiero Tamburrini, Simona Gaudino, Benedetta Pettorini, Federica Novegno, Cesare Colosimo et Concezio Di Rocco. « Endoscopic Third Ventriculostomy for the Management of Chiari I and Related Hydrocephalus : Outcome and Pathogenetic Implications ». Neurosurgery 68, n^o 4 (1 avril 2011) : 950–56. http://dx.doi.org/10.1227/neu.0b013e318208f1f3.

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Abstract BACKGROUND: Hydrocephalus affects 7% to 10% of patients with Chiari I malformation (CIM). It can be successfully treated by endoscopic third ventriculostomy (ETV), possibly improving related CIM and syringomyelia. OBJECTIVE: To confirm the effectiveness of ETV in the management of Chiari-related hydrocephalus and symptoms and to estimate the posterior cranial fossa volume (PCFV) to find the possible reasons for the success or failure of ETV. METHODS: Fifteen patients (11 children and 4 adults) underwent ETV for hydrocephalus associated with CIM (syringomyelia was present in 6 patients). Preoperative PCFV, posterior fossa brain volume (PFBV), and PFBV/PCFV ratio were calculated in the last 12 patients in the series by a magnetic resonance imaging–based computerized method. RESULTS: All patients had symptomatic hydrocephalus (mean third ventricle diameter, 14.1 mm). Mean tonsillar ectopia was 12.7 mm. Postoperatively, hydrocephalus symptoms improved in all cases (mean third ventricle diameter, 8.3 mm); signs and symptoms of CIM and syringomyelia resolved or improved in all patients, although the malformation remained radiologically stable in half of the patients (postoperative mean tonsillar ectopia, 8.8 mm). There were no remarkable differences between cases and controls with regard to PCFV and PFBV. The PFBV/PCFV ratio was comparable in pediatric cases and controls but not among adult patients, suggesting a PCF overcrowding in the controls. CONCLUSION: ETV is an effective treatment for hydrocephalus associated with CIM. It is successful in improving CIM and syringomyelia in patients with no overcrowding (mainly in children) or with reversible overcrowding of the PCF (mainly in adults).

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Azizah, Kunti Anis, Didik Pudji Restanto et Bambang Sugiharto. « Enhancement of Regeneration Efficiency through Callus Induction Media Using 2,4-Dicholorophenoxyacetic acid in Indica Rice (Oryza sativa L. var. Ciherang) ». Jurnal ILMU DASAR 18, n^o 2 (27 mai 2017) : 91. http://dx.doi.org/10.19184/jid.v18i2.2592.

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Indica rice variety Ciherang is the most planted variety in Indonesia, but the micropropagation technique is restricted because it is known has low regeneration frequency and included as recalcitrant cultivar for tissue culture and tranformation activities. One of solution to resolve that problem is developing a technique of somatic embryogenesis in callus of ciherang rice cultivar. The aims of study were to determine medium composition for inducting embryogenic callus in Ciherang rice and to know the effectivity of rice regeneration using callus as explant. The methods were included induction of embryogenic callus in callus induction media (CIM) containing MS basal, Proline 600 mg/l, Casein Hidrolisat 300 mg/l, phytagel 2,5 g/l, BAP 0.25 mg/l, sukrosa 30 %, and 2,4-D in different concentration, from 2,4-D 0 mg/l as control (CIM 1), 2,4-D 2 mg/l (CIM 2), 2,4-D 3 mg/l (CIM 3), and 2,4-D 4 mg/l (CIM 4). It then be continued to regenerate the calli in RM 1 medium containing MS basal, NAA 0,2 mg/l, Kinetin 2 mg/l, Agarose 10 g/l, and sukrosa 30 %, pH 5,8 for six days in dark and RM2 medium containing MS basal , NAA 0,2 mg/l, Kinetin 2 mg/l, Agarose 8 g/l, sukrosa 30 %, pH 5,8 in light room. Results showed CIM 4 medium using 2,4-D 4 mg/l gave optimum result in calli induction with procentage 57,63% and CIM 3 using 2,4-D 3 mg/l gave optimum result in embryonic calli induction with procentage 53,63%. Result of embryonic calli gave regeneration frequency procentage is 9,6%. The total planlet obtained after five weeks old in regeneration medum were 11 planlets ready for aclimatization. Keywords: Somatic embryo, Indica rice (Oryza sativa L. var. Ciherang), Callus

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Reed, Geoffrey, Nicolas Daumerie, Massimo Marsili, Patrice Desmons, Anne Lovell, Vincent Garcin et Jean-Luc Roelandt. « Développement de la CIM-11 de l'OMS dans les pays francophones ». L'information psychiatrique 89, n^o 4 (2013) : 303. http://dx.doi.org/10.3917/inpsy.8904.0303.

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Reed, Geoffrey, Nicolas Daumerie, Massimo Marsili, Patrice Desmons, Anne Lovell, Vincent Garcin et Jean-Luc Roelandt. « Développement de la CIM-11 de l'OMS dans les pays francophones ». L'information psychiatrique Volume 89, n^o 4 (15 mai 2013) : 303–9. http://dx.doi.org/10.1684/ipe.2013.1056.

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Gulhane, Avanti, Rafee Talukder, Atreya Dash, William J. Ellis, George Schade, Jonathan J. Chen, Emily Steinberger Weg et al. « Clinical impact of PSMA PET in patients with biochemically recurrent prostate cancer after locoregional definitive therapy. » Journal of Clinical Oncology 40, n^o 16_suppl (1 juin 2022) : e17009-e17009. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17009.

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e17009 Background: [68Ga]-PSMA-11 positron emission tomography (PSMA PET) detects sites of biochemically recurrent prostate cancer (BCR) at higher rates than conventional imaging. We hypothesized that PSMA PET would lead to high change in management (CIM) rates in this setting. Methods: We prospectively recruited patients (pts) with BCR, defined as confirmed PSA > 0.2 ng/mL > 6 weeks post-surgery or PSA ≥2 ng/mL above nadir post-radiation therapy, to undergo Ga-68 PSMA-11 PET. Some also had equivocal lesions on CT, MRI, bone scan, or fluciclovine PET obtained prior to PSMA PET. Pre-PET intended treatment, PSA (ng/mL), and PSA doubling time (PSAdt, months) from most recent 3 values were recorded prior to imaging. Post-PET treatment (intended or actual) was collected from medical record. CIM was categorized as major (change in or addition of treatment modality) vs minor (change within treatment modality, such as altered radiation field). Any lesion with uptake above blood pool was interpreted as positive for prostate cancer by an experienced PET reader (DLC). All values were represented as the median [interquartile range, IQR]. Kruskal Wallis analysis tested for significant differences among groups. Results: 44 pts with BCR age 71 [10] with Gleason scores (GS) at diagnosis of 6 (N = 2), 7 (N = 23), 8 (N = 5), and 9 (N = 13) enrolled, 14/44 with equivocal lesions on conventional imaging. 42 had post-PSMA PET treatment decisions available in medical records for CIM analysis. Time from PSA nadir to PSA at time of PSMA PET was 5 [7.25] months. PSMA PET was positive in 33 (8/33 with equivocal lesions on prior imaging; 7 local disease only; 11 regional nodal metastases, 2/11 also with local disease; and 15 with distant metastases, 4/15 also with local disease, 9/15 with regional nodal metastases), negative in 6, and equivocal in 5 pts. Of those with distant metastases, 8 had oligometastases, defined as 3 or fewer distinct sites (1 site = single nodal region or single bone lesion), 4 in bones and 4 in distant nodes. CIM rate was 71% (30/42) overall, 65.5% (16/29 major, 3/29 minor) in pts with BCR and negative conventional imaging; 84.6% (11/13, all major) in pts with equivocal lesions on conventional imaging. Of the patients with major CIM, a treatment modality was added in 21/27, modality switched in 3/27, and a modality removed in 3/27. PSA was significantly lower (p = 0.04) for those with negative or equivocal PSMA PET (0.5 [2.7]) than those with localized disease (4.1 [2.8]), regional nodal (1.1 [3.4]) or distant metastases (3.8 [5.3]), but not PSAdt (p = 0.2, negative/equivocal PET 5 [6.5], localized 15 [36], regional nodal metastases 11 [13], distant metastases 6 [6]). Conclusions: PSMA PET may impact decision making in pts with BCR after treatment of localized prostate cancer, particularly for those with equivocal findings on conventional imaging, regardless of clinical risk at diagnosis. Clinical trial information: NCT04777071.

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Gulhane, Avanti, Rafee Talukder, Atreya Dash, William J. Ellis, George Schade, Jonathan J. Chen, Emily Steinberger Weg et al. « Clinical impact of PSMA PET in patients with biochemically recurrent prostate cancer after locoregional definitive therapy. » Journal of Clinical Oncology 40, n^o 16_suppl (1 juin 2022) : e17009-e17009. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17009.

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e17009 Background: [68Ga]-PSMA-11 positron emission tomography (PSMA PET) detects sites of biochemically recurrent prostate cancer (BCR) at higher rates than conventional imaging. We hypothesized that PSMA PET would lead to high change in management (CIM) rates in this setting. Methods: We prospectively recruited patients (pts) with BCR, defined as confirmed PSA > 0.2 ng/mL > 6 weeks post-surgery or PSA ≥2 ng/mL above nadir post-radiation therapy, to undergo Ga-68 PSMA-11 PET. Some also had equivocal lesions on CT, MRI, bone scan, or fluciclovine PET obtained prior to PSMA PET. Pre-PET intended treatment, PSA (ng/mL), and PSA doubling time (PSAdt, months) from most recent 3 values were recorded prior to imaging. Post-PET treatment (intended or actual) was collected from medical record. CIM was categorized as major (change in or addition of treatment modality) vs minor (change within treatment modality, such as altered radiation field). Any lesion with uptake above blood pool was interpreted as positive for prostate cancer by an experienced PET reader (DLC). All values were represented as the median [interquartile range, IQR]. Kruskal Wallis analysis tested for significant differences among groups. Results: 44 pts with BCR age 71 [10] with Gleason scores (GS) at diagnosis of 6 (N = 2), 7 (N = 23), 8 (N = 5), and 9 (N = 13) enrolled, 14/44 with equivocal lesions on conventional imaging. 42 had post-PSMA PET treatment decisions available in medical records for CIM analysis. Time from PSA nadir to PSA at time of PSMA PET was 5 [7.25] months. PSMA PET was positive in 33 (8/33 with equivocal lesions on prior imaging; 7 local disease only; 11 regional nodal metastases, 2/11 also with local disease; and 15 with distant metastases, 4/15 also with local disease, 9/15 with regional nodal metastases), negative in 6, and equivocal in 5 pts. Of those with distant metastases, 8 had oligometastases, defined as 3 or fewer distinct sites (1 site = single nodal region or single bone lesion), 4 in bones and 4 in distant nodes. CIM rate was 71% (30/42) overall, 65.5% (16/29 major, 3/29 minor) in pts with BCR and negative conventional imaging; 84.6% (11/13, all major) in pts with equivocal lesions on conventional imaging. Of the patients with major CIM, a treatment modality was added in 21/27, modality switched in 3/27, and a modality removed in 3/27. PSA was significantly lower (p = 0.04) for those with negative or equivocal PSMA PET (0.5 [2.7]) than those with localized disease (4.1 [2.8]), regional nodal (1.1 [3.4]) or distant metastases (3.8 [5.3]), but not PSAdt (p = 0.2, negative/equivocal PET 5 [6.5], localized 15 [36], regional nodal metastases 11 [13], distant metastases 6 [6]). Conclusions: PSMA PET may impact decision making in pts with BCR after treatment of localized prostate cancer, particularly for those with equivocal findings on conventional imaging, regardless of clinical risk at diagnosis. Clinical trial information: NCT04777071.

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Reed, Geoffrey M. « Vers la CIM-11 : créer un espace pour une diversité de perspectives ». L'information psychiatrique 87, n^o 3 (2011) : 169. http://dx.doi.org/10.3917/inpsy.8703.0169.

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Bottéro, A. « Travaux préparatoires à la rédaction du chapitre V de la CIM-11 ». PSN 9, n^o 3 (30 juin 2011) : 131–38. http://dx.doi.org/10.1007/s11836-011-0175-x.

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Reed, Geoffrey M. « Vers la CIM-11 : créer un espace pour une diversité de perspectives ». L'information psychiatrique Volume 87, n^o 3 (1 mars 2011) : 169–73. http://dx.doi.org/10.1684/ipe.2011.0755.

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Aggarwal, Varun, Navodhya Jindal, Seema Rohilla, Hitesh Hitesh et Ishwar Singh. « Cerebrospinal Fluid Dynamics Study : A Unique Tool for Management of Chiari 1 Malformation Patients ». Iranian Journal of Neurosurgery 6, n^o 2 (1 avril 2020) : 57–66. http://dx.doi.org/10.32598/irjns.6.2.2.

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Background and Aim: Chiari I malformation(CIM) is defined as descent of cerebellar tonsils 5mm or more below the foramen magnum, with or without associated syrinx. Degree of tonsillar descent has a poor correlation with the progression of disease and symptomatology. Abnormal CSF dynamics at foramen magnum is the main pathophysiological factor responsible for the progression of tonsillar descent, syrinx formation and hence symptomatology. The aim of this study is to correlate CSF dynamic changes with the clinicoradiological profile of CIM patients. Methods and Materials/Patients: A prospective longitudinal study was done in 25 patients of CIM out of which 24 patients underwent standard midline suboccipital craniectomy with augmented duraplasty and 1 patient had ventriculoperitoneal shunt surgery for hydrocephalus. CSF flow study was done in sagittal as well as in axial sections at the level of foramen magnum using cine flow magnetic resonance imaging (MRI). Clinical and radiological assessment in reference to CSF flow parameters was done before and after decompression surgery. Results: After suboccipital decompression 23 out of 24 patients had relief in their symptoms and 1 patient had progressive syringomyelia. Postoperative MRI scan at 3months showed round shaped tonsils in all 24 patients. Ten out of 11 patients with syrinx had reduction in diameter of syrinx cavity. Peak CSF flow velocities reduced significantly (p value < 0.05) in the postoperative period and correlated well with the clinicoradiological improvement. Conclusion: Abnormal CSF flow dynamics is responsible for the progression of disease and symptomatology in CIM patients. Cine flow MRI is a useful tool in the management of CIM patients both for proper selection of surgical candidates and in post-operative follow-up.

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Nikiphorou, E., S. Péloquin, M. Augustyniak, A. Negoescu, D. Walker, F. Haq, P. Lazure et S. Murray. « POS1555-HPR EVALUATION OF CONVERSATIONS IN MOTION : A PROGRAM DESIGNED TO IMPROVE PATIENT-PROVIDER COMMUNICATION IN THE CARE OF RHEUMATOID ARTHRITIS ». Annals of the Rheumatic Diseases 81, Suppl 1 (23 mai 2022) : 1122.1–1123. http://dx.doi.org/10.1136/annrheumdis-2022-eular.115.

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BackgroundPrevious studies have found a need for improvement in communications between healthcare professionals (HCPs) and patients with rheumatoid arthritis (RA), especially in relation to shared-decision making (SDM), management of expectations, and goal-setting.1-2Conversations in Motion (CIM) is an educational program, consisting of four modules, that teaches HCPs how to use validated communication techniques to improve the quality and efficiency of their consultations with RA patients.ObjectivesThis pilot study assessed the impact of CIM deployed in the United Kingdom (UK) on HCPs’ knowledge, skills, confidence, beliefs, and performance using validated communication techniques in interactions with RA patients.MethodsA longitudinal mixed-methods study, consisting of three surveys (pre/before the program, 2-3 weeks post, and 5-6 months follow-up) and semi-structured interviews (4-6 weeks post) was used to evaluate CIM based on the outcome model by Moore et al.3 Surveys assessed outcomes via multiple choice or 11-point rating scale questions (0-none, 10-extreme). Participants included UK rheumatology physicians, nurses, and allied HCPs, all of whom had a minimum yearly caseload of 10 RA patients and participated in CIM between September and October 2020. Survey data was descriptively analysed in SPSS by comparing pre with post and pre with follow-up (matched samples). Interviews were thematically analysed using NVivo.ResultsAlmost half (15/34) of registrants completed all four CIM modules. Of those, 53% (n=8) completed pre and post surveys; 33% (n=5) pre and follow-up surveys; and 27% (n=4) completed interviews. Post surveys showed greater knowledge for strategies to build trust and empathy with RA patients and practice efficiency than at pre (Figure 1). A decrease in helplessness was noted for dealing with a patient who is nonadherent (pre=3.9/10; post=1.6/10). Interviewees described CIM as “thought provoking” and reported improvement in their ability and confidence to use patient’s own stories and words as a strategy to build trust and empathy (n=4). Post and follow-up surveys showed changes in skills and confidence were more pronounced for practice efficiency and discussing nonadherence (Table 1). At follow-up, most participants reported practicing at least one technique to build trust and empathy with patients (80%, 4/5), save time (100%, 5/5), engage in SDM, or discuss nonadherence (60%, 3/5).Table 1.Changes in skill and confidence post-CIMMatched respondents (n=8)Matched respondents (n=5)Survey itemPrePostΔPreFollow-upΔSkillAssisting patients in the conceptualization of treatment pros and cons5.67.1+15%5.46.4+10%Listening to and understanding patients’ emotions, expectations, and personal needs6.68.1+15%7.08.2+18%Simplifying complex terminology related to RA5.47.8+24%5.47.2+16%Discussing reasons for nonadherence5.47.8+24%4.26.4+22%ConfidenceEngaging in shared decision making6.17.9+18%5.06.2+12%Building trust and empathy via telemedicine5.96.9+10%5.06.0+10%Addressing patient concerns in limited consultation5.26.6+14%4.05.6+16%Support patients through treatment adherence6.07.5+15%4.06.2+22%Table description: All items were rated on an 11-point scale (0-none, 10-extreme). The matched sample of participants who completed the pre and 2-3 weeks post-CIM survey was not the same as the one who completed the pre and 5-6 months follow-up survey. Change (Δ) was measured as the percent difference between means.ConclusionThis pilot evaluation suggests that CIM has a measurable impact on HCPs’ learning and use of techniques that can enhance communication and collaboration with RA patients. Future studies should validate CIM impact in a larger sample size and/or by evaluating patients’ perspective on observed changes in their communication and collaboration with HCPs.References[1]Strand V et al. J Rheumatol 2015;42;2046-54.[2]Murray S et al. BMJ Open 11:e043960[3]Moore Jr DE et al. J Contin Education Health Prof 2009;29(1):1-15.AcknowledgementsThe authors thank all participants in this study and acknowledge the contributions and support of Olivier Jacob, Senior Project Manager, AXDEV Group Inc.Disclosure of InterestsElena Nikiphorou Speakers bureau: Celltrion, Pfizer, Sanofi, Gilead, Galapagos, AbbVie, Eli Lilly, Grant/research support from: Pfizer and Eli Lilly, Sophie Péloquin: None declared, Monica Augustyniak: None declared, Andra Negoescu Speakers bureau: Eli Lilly, Bristol Myers Squibb, Galapagos, Abbvie, David Walker Speakers bureau: Eli Lilly, Galapagos, Consultant of: Galapagos, Gilead Sciences, Grant/research support from: Gilead Sciences, Fasiha Haq Shareholder of: Eli Lilly, Employee of: Eli Lilly, Patrice Lazure: None declared, Suzanne Murray: None declared

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Sainz, R. D., et J. E. Wolff. « Evaluation of hypotheses regarding mechanisms of action of growth promotants and repartitioning agents using a simulation model of lamb metabolism and growth ». Animal Science 51, n^o 3 (décembre 1990) : 551–58. http://dx.doi.org/10.1017/s0003356100012587.

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ABSTRACTResponses of lambs to cimaterol (CIM), diethylstylbestrol (DES) and ovine growth hormone (GH) were examined using a mechanistic model of growing lamb metabolism. All three compounds increase growth of lean tissue (protein) and decrease fat gain, although the magnitudes of these responses vary. Our working hypothesis was that observed changes in nutrient partition between lean and fat gain were caused by alteration of rate constants for turn-over of muscle protein and fat. Individual experiments were simulated whilst varying values of the protein degradation constant (Kprolein) and Vmax for lipolysis (Kfat). Optimal parameter values were found by minimizing residual errors, calculated as the deviations of model predictions from experimental values for carcass protein and fat. Fitted values of Kfat and Kprotein (expressed as proportions of controls) for each simulation were: CIM (grazing), 1·20 (s.d. 0·05) and 0·86 (s.d. 0·025); CIM (pellet-fed), 1·11 (s.d. 0·115) and 0·87 (s.d. 0·032); DES, 1·33 (s.d. 0·111) and 0·94 (s.d. 0·024); GH, 1·77 (s.d. 0·139) and 0·97 (s.d. 0·025) respectively. These results demonstrate that different mechanisms may be responsible for the changes in carcass composition due to 3-adrenergic agonists, anabolic steroids and growth hormone. CIM probably exerts its effects via changes in protein and fat metabolism, whereas DES and GH appear to act mainly through changes in adipose tissue, with little or no effect on the rate constant for protein turn-over. Carcass composition is less sensitive to manipulation of adipose tissue metabolism than to changes in muscle protein metabolism.

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Drummond, Elislene Dias, Juliana Quero Reimão, Amanda Latercia Tranches Dias et Antônio Martins de Siqueira. « Comportamento de amostras ambientais e clínicas de Cryptococcus neoformans frente a fungicidas de uso agronômico e ao fluconazol ». Revista da Sociedade Brasileira de Medicina Tropical 40, n^o 2 (avril 2007) : 209–11. http://dx.doi.org/10.1590/s0037-86822007000200012.

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Avaliou-se a atividade de fungicidas azólicos de uso agronômico (epoxiconazol, difenoconazol e ciproconazol) em comparação ao antifúngico de uso terapêutico fluconazol sobre 23 amostras ambientais de Cryptococcus neoformans var neoformans isoladas de fezes de pombos, as quais foram coletadas em fazendas com práticas agrícolas empregando compostos azólicos e 11 amostras clínicas isoladas de pacientes portadores de criptococose. Os testes de sensibilidade foram realizados pela técnica de diluição em agar. A concentração inibitória mínima capaz de inibir 50% dos isolados ambientais (CIM 50) foi de 6,0µg/mL para epoxiconazol, 1,0µg/mL para difenoconazol, 2,0µg/mL para ciproconazol e 64,0µg/mL para fluconazol. Entre os isolados clínicos os valores de CIM 50 foram 2,0µg/mL, 0,38µg/mL, 1,0µg/mL e 16,0µg/mL para epoxiconazol, difenoconazol, ciproconazol e fluconazol, respectivamente. Os valores de CIM 50 em relação aos isolados de origem ambiental foram maiores do que os valores para os isolados de origem clínica. Em nosso estudo, frente ao mesmo antifúngico, as amostras ambientais apresentaram comportamento significativamente diferente em relação às amostras clínicas (p < 0,05). Diferenças (p<0,05) também foram observadas entre os valores de concentração inibitória apresentados pelo fluconazol e os outros antifúngicos de uso agronômico tanto no grupo dos isolados ambientais quanto clínicos.

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Kipper, Michael S., et Paul Dato. « Identification of bone involvement in patients with prostate cancer recurrence using 18F-fluciclovine PET/CT and impact on subsequent management. » Journal of Clinical Oncology 37, n^o 7_suppl (1 mars 2019) : 248. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.248.

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248 Background: Bone is the most frequent site of metastasis in prostate cancer. Accurate localization of recurrence following primary treatment can help optimize salvage therapy. Positron emission tomography (PET) tracer, 18F-fluciclovine, is approved in Europe and the US for men with rising prostate specific antigen (PSA) after prior treatment. LOCATE was a prospective trial to study the impact of 18F-fluciclovine PET/computed tomography (PET/CT) on management of men with prostate cancer recurrence and negative standard imaging after curative intent treatment. Here, we explore changes in management (CIM) in men with 18F-fluciclovine-avid bone lesions. Methods: 18F-Fluciclovine PET/CT was performed and interpreted according to standard practice at 15 US centers. Eligible men (≥ 18 y; prior curative intent treatment of prostate cancer; recurrence based on rising PSA; negative/equivocal findings on standard bone and pelvic imaging) had their treatment plans recorded pre- and post-scan. Results: A total of 213 men (median pre-scan PSA, 1.0 ng/mL) were enrolled. Overall, 18F-fluciclovine detected lesions in 122 (57%) and 126 (59%) had CIM post-scan. 18F-Fluciclovine-avid bone lesions were found in 23 (11%) men. Prior to the fluciclovine scan, 21 (91%) had a 99mTc-MDP scan (20 negative, 1 equivocal results), 1 (4%) had an unspecified bone scan (negative result) and 1 (4%) did not receive a bone-specific scan. Of the 23 men with positive scans, 15 (65%) had post-scan CIM: ADT added to planned radiotherapy (RT; 4, 27%); ADT replaced with targeted treatment of fluciclovine-positive extrapelvic bony areas (4, 27%); RT modified to target fluciclovine-positive areas (4, 27%); modified ADT regime (2, 13%); and watchful waiting in favor of RT (1, 7%). The majority of men with no post-scan CIM were prescribed ADT (6/8, 75%). Conclusions: Despite negative standard bone imaging,18F-fluciclovine localized recurrence of prostate cancer to bone in 11% of patients; the majority of whom had a management change as a result, frequently in order to target fluciclovine-positive sites. Further study to investigate the clinical outcomes of such changes is warranted. Clinical trial information: NCT02680041.

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Tanno, L. K., et P. Demoly. « L'anaphylaxie dans la Classification Internationale des Maladies (CIM)-11 : contexte, situation actuelle et perspectives ». Revue Française d'Allergologie 61, n^o 8 (décembre 2021) : 8S24–8S29. http://dx.doi.org/10.1016/s1877-0320(21)00438-3.

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Mokaddem, Y., N. Melin, M. Bensadon, J. Dubois et G. Rey. « Traduction française de la 11e révision de la Classification internationale des maladies (CIM-11) ». Revue d'Épidémiologie et de Santé Publique 68 (mars 2020) : S38. http://dx.doi.org/10.1016/j.respe.2020.01.084.

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Park, Soon O., Dermot P. Coyne, Geunhwa Jung, Paul W. Skroch, E. Arnaud-Santana et James R. Steadman. « 554 Mapping of QTL for Seed Size and Shape Traits in Common Bean ». HortScience 35, n^o 3 (juin 2000) : 491C—491. http://dx.doi.org/10.21273/hortsci.35.3.491c.

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Our objective was to identify QTL for seed weight (SW), length, and height segregating in a recombinant inbred line (RIL) population from the cross `PC-50' (Larger SW) × XAN-159 (Smaller SW). The parents and RILs were grown in two separate greenhouse experiments in Nebraska, and in field plots in the Dominican Republic and Wisconsin. Data analysis was done for individual environments separately and on the mean over all environments. A simple linear regression analysis of all data indicated that most QTL appeared to be detected in the mean environment. Composite interval mapping (CIM) analysis was then applied to the means over environments. Eight QTL for SW were detected on common bean linkage groups (LGs) 3, 4, 5, 6, 7, and 8. All eight markers associated with these QTL were significant in a multiple regression analysis (MRA), where the full model explained 63% of the variation among SW means. Six QTL for seed length were detected on LGs 2, 3, 4, 8, and 11 using CIM. The markers associated with the three seed length QTL on LGs 2, 8, and 11 were significant in a MRA with the full model explaining 48% of the variation among seed length means. Three QTL for seed height on LGs 4, 6, and 11 explained 36% of the phenotypic variation for trait means. Four of the six QTL for seed length and two of three QTL for seed height also appeared to correspond to QTL for SW.

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Silva, Viviane Araújo da, Andréia Fernanda Ramos de Freitas, Maria do Socorro Vieira Pereira et Andréia Vieira Pereira. « AVALIAÇÃO DA ATIVIDADE ANTIMICROBIANA “IN VITRO” DA Lippia sidoides CHAM SOBRE Staphylococcus aureus DE ORIGEM BOVINA ». AGROPECUÁRIA CIENTÍFICA NO SEMIÁRIDO 5, n^o 1 (29 septembre 2010) : 52–56. http://dx.doi.org/10.30969/acsa.v5i1.56.

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Staphylococus aureus apresenta-se como um microorganismo patogênico clássico sendo comumente reconhecido como agente etiológico de infecções hospitalares e comunitárias. Através do conhecimento das propriedades biológicas do Alecrim-pimenta (Lippia sidoides. Cham), esta pesquisa teve como objetivo avaliar a atividade antimicrobiana “in vitro” do óleo essencial desta planta em inibir o crescimento de cepas de S. aureus isoladas de secreções do úbere, fossas nasais e do leite. Os resultados mostraram destacável atividade anti-estafilococicas aureus do extrato da Lippia sidoides Cham notadas por halos de inibição do crescimento bacteriano (11 a 26 mm). A concentração inibitória mínima (CIM) encontrada foi de 1:8 para todas as amostras estudadas. A CIM apresentou eficácia na inibição da viabilidade de S. aureus em caldo durante vinte e quatro horas de interação, caracterizando efeito bacteriostático. Esses resultados demonstram a atividade anti-estafilococicas do extrato de Lippia sidoides, bem como, suportam a possibilidade de seu uso como agente antimicrobiano.

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Pfirrmann, Markus, Susanne Saussele, Michele Baccarani, Joelle Guilhot, Francisco Cervantes, Gert J. Ossenkoppele, Doris Lindoerfer et al. « Survival and Prognosis in Patients with First-Line Imatinib Treatment Under Particular Consideration of Death Due to Chronic Myeloid Leukemia ». Blood 124, n^o 21 (6 décembre 2014) : 153. http://dx.doi.org/10.1182/blood.v124.21.153.153.

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Abstract Introduction: The IN-study section of the European Treatment and Outcome Study (EUTOS) registry comprises data on imatinib-treated patients with chronic myeloid leukemia (CML) who were enrolled between 2002 and 2006 in prospective, controlled clinical trials. Of those, 2290 adult patients had Philadelphia chromosome-positive chronic-phase (CP) CML and were eligible for analysis and prognosis of long-term survival. Improved survival increased the percentage of deaths not related to CML. While adjusting for this, our analyses put death due to CML into focus. Aims: Based on the observed survival in our patient sample and on survival in matched population data, relative survival (RS) probabilities attributable to the excess hazard of CML should be calculated for the 2290 patients. These results were to be opposed to cumulative incidences of mortality (CIM) when only death due to CML is considered as an event and all other causes of death as competing risks. The ability to discriminate CIM of dying from CML should be assessed for the established prognostic models Sokal, Euro, and EUTOS score and a possibly identified new model. Candidate factors were age, sex, spleen enlargement, hemoglobin, platelets, leukocytes, and percentages of blasts, eosinophils, and basophils in peripheral blood. Methods:Survival time was calculated from the date of start of treatment to death or to the latest follow-up date. Survival was censored at the time of allogeneic stem cell transplantation in first CP. As “death due to CML”, only death after recorded disease progression was regarded. Progression was given by observation of accelerated phase or blast crisis, both defined in accordance with the recommendations of the ELN (Baccarani et al Blood 2013). RS probabilities were calculated by the method of Pohar-Perme (Comput Biol Med 2007) and CIM by the cumulative incidence function. Population data was downloaded from the Human Mortality Database (www.mortality.org). All prognostic factors were measured at baseline and the influence on CIM due to CML was estimated by the Fine and Gray (FG) model. Level of significance was 0.05. Results:The 2290 patients came from study groups in Germany, France, Italy, Spain, the Netherlands, and the Nordic study group and had a median observation time of 6.4 years. Observed 8-year overall survival probability was 89% [95% confidence interval (CI): 87-90%] and 8-year RS probability 96% [95% CI: 93-97%]. Cause of death was due to CML in 92 of 208 cases (44%), unrelated to CML in 104 (50%), and unknown in 12 cases (6%). Eight-year CIM were 4% [CI: 4-5%] for causes of death due to CML and 7% [CI: 6-8%] for causes of death due to other reasons, including the unknown causes where no progression prior to death was observed. From low to high risk groups, in 2205 evaluable patients, the Sokal score resulted in 8-year CIM of 3% [95% CI: 2-4%], 4% [95% CI: 3-6%], and 7% [n=499, 95% CI: 5-10%] and the Euro score in 8-year CIM of 4% [95% CI: 3-5%], 3% [95% CI: 2-4%], and 12% [n=222, 95% CI: 8-17%]. The EUTOS score suggested two groups with 8-year CIM of 4% [95% CI: 3-5%] and 9% [n=232, 95% CI: 5-13%]. Higher age, more blasts, a bigger spleen size enlargement, and low platelet counts significantly increased the CIM of dying from CML. The four factors were combined in a new prognostic model. Here, 8-year CIM were 2% [n=1349, 95% CI: 1-3%], 6% [n=596, 95% CI: 4-8%], and 11% [n=260, 95% CI: 8-16%]. Conclusions: An 8-year RS probability of 96% corresponded to an estimated 4% probability of dying due to CML which actually was the same result as the one calculated for the CIM. However, while for the first method, access to matched population data is necessary but no knowledge on the cause of death, in the second case, investigators need to assess whether an individual died from CML or not. Using the “progression prerequisite”, the FG model was most likely only based on “real” cases of death due to CML. As causes of death without prior progression, like infection or treatment-related toxicities, might well be attributable to CML, the CIM of death due to CML were supposedly underestimated. For assessment of comparability between patient samples, prognostic models built from baseline variables remain important. In comparison to other scores, only the new model identified three risk groups with pairwise significantly different CIM and led to the largest high-risk group with an 8-year CIM above 10%. Independent data for further comparisons are collected. Disclosures Pfirrmann: Novartis: Consultancy; Bristol-Myers Squibb: Honoraria. Saussele:Novartis: Honoraria, Research Funding, Travel grant Other. Baccarani:Novartis: Consultancy, Honoraria, Speakers Bureau; Bristol-Myers Squibb: Consultancy, Honoraria, Speakers Bureau; Pfizer: Consultancy, Honoraria, Speakers Bureau; Ariad: Consultancy, Honoraria, Speakers Bureau. Ossenkoppele:Novartis: Consultancy, Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding. Lindoerfer:Novartis: Research Funding. Hoffmann:Novartis: Research Funding. Castagnetti:Novartis: Consultancy, Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria. Hehlmann:Novartis: Research Funding; Bristol-Myers Squibb: Research Funding.

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Delègue, Anne. « Les « troubles du neuro-développement » : concept et diagnostic(s) problématique(s) aux multiples conséquences ». Nouvelle Revue de l'Enfance et de l'Adolescence N° 10, n^o 1 (19 juin 2024) : 131–66. http://dx.doi.org/10.3917/nrea.010.0131.

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Le concept de « troubles neurodéveloppementaux » diffusé depuis dix ans dans la nomenclature psychiatrique internationale par le DSM est examiné : historique, composition détaillée (DSM-5 et CIM-11), position de la CFTMEA, validité scientifique et épistémologique, lien avec la psychiatrie biologique , enfin conséquences : abandon d’une psychopathologie plurielle, neurologisation et « standardisation » conceptuelles, diagnostiques et soignantes de la pédopsychiatrie, posant des problèmes éthiques de la même importance que la pathologisation de l’homosexualité en son temps.

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Du Vall, Marilyn, Linda Weffald, Thomas Delate, Susan Shetterly et Elizabeth A. Bayliss. « Clinical Factors Associated With Nonadherence to Chronic Medications in People With Cognitive Impairment ». Senior Care Pharmacist 37, n^o 5 (1 mai 2022) : 191–99. http://dx.doi.org/10.4140/tcp.n.2022.191.

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Objective To study assessed adherence to 11 chronic medications and one medication class with high medical necessity in people with cognitive impairment (CIM) and identified clinical characteristics associated with nonadherence. Design This was a retrospective cohort study. 180-day adherence was calculated as the percent of days covered (PDC). Multi-variable logistic regression modeling was used to identify clinical factors associated with a PDC less than 80% (ie, nonadherence) to one or more studied chronic medication(s). Setting Primary care in an integrated health care delivery system. Patients People with CIM 65 years of age or older who were dispensed five or more chronic medications in one month between March 1, 2019, and October 31, 2019. Results Overall, the 1,109 patients included were older (mean age = 79.8 years of age), female (54.1%), White (78.6%), had a high burden of chronic disease, and 396 (35.7%) were nonadherent to one or more study medication(s). Two medications (tiotropium and venlafaxine) and one medication class (direct oral anticoagulants) had a mean PDC less than 80%. Alzheimer’s disease and related dementias (ADRD), chronic pain, chronic obstructive pulmonary disease (COPD), male, nonwhite race, and one or more mental health visits were associated independently with nonadherence. Conclusions Chronic pain, COPD, ADRD, male sex, nonwhite race, and mental health care use were associated with nonadherence. These findings can help guide clinicians as they navigate medication therapy in people with CIM.

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Da Fonseca Holz, Raquel, Clara Natalia Steigleder, Maurício Pinto da Silva et Pedro Mascarenhas de Souza Pinheiro. « Gestão para a sustentabilidade : a implementação do ODS 11 em evidência ». Expressa Extensão 28 (18 décembre 2023) : 7–15. http://dx.doi.org/10.15210/ee.v28i.25564.

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Este artigo explora as possibilidades advindas do Curso de Especialização Lato Sensu em Gestão para a Sustentabilidade do Centro de Integração do Mercosul (CIM), destacando a importância que adquire o ODS 11 para pensar a gestão na área. Enfatizando sua base sólida na interação entre a universidade e a sociedade, na integração dos Objetivos de Desenvolvimento Sustentável (ODS) e da ênfase na aplicação prática dos princípios da sustentabilidade, o curso reconhece a interligação e a indivisibilidade dos ODS. A partir de uma abordagem holística, envolvendo as áreas que compõem o curso (Hospitalidade urbana, Gestão Sustentável e Mobilidade Urbana Sustentável), o que permite uma análise abrangente da questão da sustentabilidade, neste artigo nos deteremos nas possibilidades de elaborar estudos e propostas visando a implementação do ODS 11. Palavras-chave: Sustentabilidade; Pós-graduação; ODS 11

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Marsili, M., A. C. Stona, D. Sebbane, M. Laporta et J. L. Roelandt. « Implication des usagers et des aidants dans le développement de la classification des troubles mentaux et du comportement, CIM-11 ». European Psychiatry 29, S3 (novembre 2014) : 620–21. http://dx.doi.org/10.1016/j.eurpsy.2014.09.107.

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ContexteL’Organisation mondiale de la santé (OMS) a inscrit la participation de tous les acteurs concernés par la classification internationale des maladies (CIM) dans son processus de révision. L’implication des usagers et des aidants jusque-là partielle, est de plus en plus importante et implique une nouvelle méthodologie de révision où leurs rôles ne soient pas annexes mais essentiels, tout en respectant le cadre contraint de la révision. Des travaux préliminaires menés à Lille et à Montréal ont souligné l’importance de travailler avec les usagers et aidants sur les lignes directrices de la CIM et sur l’intégration d’éléments contextuels à la classification.Objectifs– Garantir la participation des usagers et aidants au processus de révision de la CIM.– Intégrer des éléments contextuels à la classification.– Proposer des recommandations à l’OMS permettant d’aboutir à une classification des troubles mentaux et du comportement compréhensible et acceptable par toutes les parties prenantes.MéthodeÉtude internationale, formative et participative, multicentrique, conduite auprès des usagers, des aidants et des professionnels volontaires entre 2014 et 2015. Axes :– intégration d’éléments contextuels dans la classification des troubles mentaux et du comportement;– relecture de la classification sur le spectre de la schizophrénie et autres troubles psychotiques primaires.Recueil des données : utilisation d’une triangulation de méthodes :– réunions de travail et focus groupes;– analyse de documents;– questionnaire électronique.Analyse des donnéesRéalisation d’une analyse statistique, d’une analyse de contenu, et création de cartes mentalesRésultats attendusDes recommandations claires et précises pour l’OMS seront élaborées à l’issue de ce projet. Celles-ci devront permettre d’aboutir à une classification des troubles mentaux et du comportement compréhensible et acceptable par toutes les parties prenantes, et sur le long-terme moins stigmatisante pour les usagers et aidants.

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Furth, Christian, Ingo G. Steffen, Holger Amthauer, Juri Ruf, Daniel Misch, Stefan Schönberger, Carsten Kobe et al. « Early and Late Therapy Response Assessment With [18F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin's Lymphoma : Analysis of a Prospective Multicenter Trial ». Journal of Clinical Oncology 27, n^o 26 (10 septembre 2009) : 4385–91. http://dx.doi.org/10.1200/jco.2008.19.7814.

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Purpose In adult Hodgkin's lymphoma (HL) risk stratification after early therapy response assessment with [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) seems to allow tailoring therapy with less toxicity for patients with adequate metabolic response. This study delivers the first prospective data on the potential of FDG-PET for response assessment in pediatric HL. Patients and Methods FDG-PET was performed in 40 pediatric HL patients before polychemotherapy (PET-1), after two cycles of polychemotherapy (PET-2), and after completion of polychemotherapy (PET-3). Mean follow-up was 46 months (range, 26 to 72 months). Results At early and late response assessment, the proportion of PET-negative patients was significantly higher compared with those patients with negative findings in conventional imaging methods (CIMs; PET-2, 26 of 40 v CIM-2, one of 40; P < .001; PET-3, 21 of 29 v CIM-3, four of 29; P < .001). Sensitivity and negative predictive value were 100% for early and late therapy response assessment by PET. Both patients suffering a relapse during follow-up were identified by PET-2/3, whereas one of these patients was not detected by CIM-3. PET was superior to CIMs with regard to specificity in early and late therapy response assessment (68% v 3%, and 78% v 11%, respectively; both P < .001). Specificity of early therapy response assessment by PET was improved to 97% by quantitative analysis of maximal standardized uptake value reduction using a cutoff value of 58%. Conclusion Pediatric HL patients with a negative PET in response assessment have an excellent prognosis while PET-positive patients have an increased risk for relapse.

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Cervesato, Adrien, et E. Owen D. Waygood. « Children’s Independent Trips on Weekdays and Weekends : Case Study of Québec City ». Transportation Research Record : Journal of the Transportation Research Board 2673, n^o 4 (27 mars 2019) : 907–16. http://dx.doi.org/10.1177/0361198119837225.

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Children’s independent mobility (CIM) on school days (weekdays) and on the weekend are examined in this study. Previous studies have focused primarily on weekday trips, with a vast majority only examining trips to school. However, the types of trips and the available time differ between weekdays and weekends. Weekday trips are more regular and possibly more local, whereas on the weekend the children may have more free time (i.e., no school) to engage in activities. Parents (as a group) are also less likely to have work obligations, and thus potentially more time, on the weekend. Theoretically, each context for the weekend could facilitate more independent or active mode trips. Nonetheless, this may be linked to whether destinations are local, which is linked to the built environment. Using origin–destination data (2011) for the City of Québec, this paper will expand knowledge in the field of children’s travel by examining all trips during a weekday ( n = 979) and weekend ( n = 315) for children aged 9 to 11 across five built environment types. The findings show that weekend trips are rarely independent, and that the key explanatory factors for greater CIM are shorter distances, having an older sibling, and more urban environments. Other sociodemographic variables were not significant or were inconsistent between the two types of weekday.

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Gauld, Christophe, et Élise Mamimoué. « Dans quelle mesure la CIM-11 peut-elle être considérée comme un hub épistémique pour la psychiatrie ? » L'information psychiatrique 98, n^o 6 (1 juillet 2022) : 442–48. http://dx.doi.org/10.1684/ipe.2022.2439.

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Park, Soon O., Dermot P. Coyne, Geunhwa Jung, Paul W. Skroch, E. Arnaud-Santana, James R. Steadman, H. M. Ariyarathne et James Nienhuis. « Mapping of QTL for Seed Size and Shape Traits in Common Bean ». Journal of the American Society for Horticultural Science 125, n^o 4 (juillet 2000) : 466–75. http://dx.doi.org/10.21273/jashs.125.4.466.

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Our objective was to identify quantitative trait loci (QTL) for seed weight, length, and height segregating in a recombinant inbred line population derived from the common bean (Phaseolus vulgaris L.) cross `PC-50' × XAN-159. The parents and progeny were grown in two separate greenhouse experiments in Nebraska, and in field plots in the Dominican Republic and Wisconsin. Data analysis was done for individual environments separately and on the mean over all environments. A simple linear regression analysis of all data indicated that most QTL appeared to be detected in the mean environment. Based on these results, composite interval mapping (CIM) analysis was applied to the means over environments. For seed weight, strong evidence was indicated for five QTL on common bean linkage groups (LGs) 3, 4, 6, 7, and 8. Multiple regression analysis (MRA) indicated that these QTL explained 44% of the phenotypic variation for the trait. Weaker evidence was found for three additional candidate QTL on bean LGs 4, 5, and 8. All eight markers associated with these QTL were significant in a MRA where the full model explained 63% of the variation among seed weight means. For seed length, CIM results indicated strong evidence for three QTL on LG 8 and one on LG 2. Three additional putative QTL were detected on LGs 3, 4, and 11. The markers associated with the three seed length QTL on LG 8, and the QTL on LGs 2 and 11 were significant in a MRA with the full model explaining 48% of the variation among seed length means. For seed height, three QTL on LGs 4, 6, and 11 explained 36% of the phenotypic variation for trait means. Four of the seven QTL for seed length and two of three QTL for seed height also appeared to correspond to QTL for seed weight. Four QTL for common bacterial blight resistance [Xanthomonas campestris pv. phaseoli (Smith Dye)] and for smaller seed size were associated on LGs 6, 7, and 8. The implications of these findings for breeders is discussed.

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Matulonis, U., H. Lee, W. Lu, A. Goodman, A. Rosulek, A. Doherty, A. Kornblith et al. « Randomized trial of acupuncture versus sham control for prevention of myelosuppression in patients with gynecologic malignancies ». Journal of Clinical Oncology 25, n^o 18_suppl (20 juin 2007) : 19524. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19524.

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19524 Background: CIM is a significant toxicity that is treated with cytokine growth factors, dose reductions and/or delays. Preliminary uncontrolled Chinese studies suggest that acupuncture lessens CIM. Methods: Patients (pts) with newly diagnosed or recurrent gyn cancers receiving chemotherapy were eligible. Trial design was a double blinded, randomized trial of active acupuncture or sham for 5 weeks (administered 3x per week). Primary endpoints were first nadir WBC and ANC levels at chemo cycle 2; other endpoints were recovering counts following the cycle 2 nadir, QOL, G-CSF levels, and feasibility. Results: >460 patients were screened. 21 pts were randomized to either active acupuncture (n=11) or sham control (n=10). Median age of the pts was 55 yrs (range: 28–81). 15 pts have completed the acupuncture treatment to provide the baseline and nadir WBC and ANC. Toxicities related to either sham or active acupuncture were minimal. The active pts group showed higher baseline WBC (median: 3,600 vs. 2,600, NS) and ANC (median: 2,269 vs. 1,922, NS) values. The nadir WBC was higher in the pts receiving acupuncture (median 3,600 vs. 2,300) but the difference was not statistically significant after adjusting for the baseline difference (p=0.16). Nadir ANC was higher among the pts receiving acupuncture (median: 2,424 vs. 1,274) but the difference was not statistically significant after adjusting for the baseline difference (p=0.1107). Recovering WBC in the pts receiving acupuncture was higher (median: 8,600 vs. 4,400) after adjusting for the baseline difference (p=0.045). The recovering ANC in the pts receiving acupuncture was higher (median: 6,530 vs. 4,038) but this difference was not statistically significant after adjusting for the baseline difference (p=0.0919). QOL and G-CSF data will be presented at ASCO. Conclusions: Although a larger randomized trial is necessary to determine the effects of acupuncture on CIM, there were consistent trends, and recovering WBC counts were significantly higher in patients receiving acupuncture. Formal evaluation of CAM is vital to confirm potentially clinically meaningful benefits. No significant financial relationships to disclose.

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Pfirrmann, Markus, Susanne Saussele, Michele Baccarani, Joelle Guilhot, Francisco Cervantes, Gert J. Ossenkoppele, Doris Lindörfer et al. « Overall Survival and Prognosis In Patients With First-Line Imatinib Treatment Under Consideration Of Death Due To Any Cause and Death Due To Chronic Myeloid Leukemia Only ». Blood 122, n^o 21 (15 novembre 2013) : 382. http://dx.doi.org/10.1182/blood.v122.21.382.382.

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Abstract Introduction As a part of the European Treatment and Outcome Study (EUTOS), the IN-study registry collected data on patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) enrolled in prospective clinical trials. Patients had to have been in chronic phase (CP) and imatinib-based treatment been started within half a year after diagnosis. Meanwhile, median observation time seemed to allow the analysis of overall survival (OS) and a possible identification of prognostic factors. Aims For OS with death due to any cause and for cumulative incidences of mortality (CIM) due to CML only, we planned to describe probabilities as well as to analyze the prognostic influence of the candidate factors age, sex, spleen enlargement, hemoglobin, platelets, leukocytes, and percentages of blasts, eosinophils, and basophils in peripheral blood (PB) on the respective probabilities. Methods Survival of patients fulfilling the inclusion criteria was censored at the time of allogeneic stem cell transplantation (SCT) in first CP. Allowing any cause of death as an event, prognostic influence on OS was estimated with multiple Cox regression allowing fractional polynomials for continuous variables. These results were opposed to the findings when cause of death was restricted to CML only and then analyzing a) cause-specific hazards by standard Cox regression and b) subdistribution hazards of the CIM with the Fine and Gray model. All prognostic factors were measured at baseline. Level of significance was 0.05. Results Patients joined study groups in Germany, France, Italy, Spain, the Netherlands, or the Nordic study group. Analyses were based on 2127 patients of five studies with similar follow-up patterns. Median observation time was 6.4 years. Eight-year survival probability was 89% [95%-confidence interval (CI): 87-90%]. Allogeneic SCT in first CP was performed in 94 patients (4%). The sample for regression analysis comprised 2067 patients with complete data for the candidate prognostic factors. Their median age was 51 years [range: 18-88], 60% were male. Altogether, 187 patients died. With death due to any cause as event, higher age and bigger spleen size enlargement (cm below costal margin) significantly reduced OS probabilities. Besides, multiple modeling also suggested that the interaction between sex and hemoglobin had a significant influence on survival. Females with lower hemoglobin values had less favorable survival probabilities while hemoglobin showed no effect in males. Judged by experienced physicians, in 89 cases (48% of 187), cause of death was CML-related (not related to CML: n=87 (47%), unknown cause: n=11 (6%)). Eight-year CIM due to CML was 5% [95%-C.I.: 4-6%] and 6% [95%-C.I.: 5-8%] due to other causes. Cause-specific Cox regression with death due to CML as the only event resulted in the same prognostic factors as for the analysis with any cause of death as event – apart from one exception: now, higher percentages of blasts in PB had a significantly negative effect, too. The analysis of the influence of prognostic factors on the CIM due to CML via the Fine and Gray model, which took the competing risk of dying due to other cause (87+11=98) into account, led to the same prognostic factors as for the cause-specific Cox model where death due to other cause was censored. Conclusions Median observation time and the number of events actually allowed a reasonable modeling of OS probabilities and CIM, even though the restriction on the cause of death due to CML reduced the number of events by about 50% in the second case. Also when considering only deaths due to CML, age remained significant and seems to be a true prognostic factor for long-term survival outcome when suffering from CML. However, age did not become part of the EUTOS score investigating the influence of various factors on the achievement of complete cytogenetic remission within 18 months (Hasford et al., Blood 2011) and this showed that imatinib-based treatment helps in any age. After all, significantly higher but still relatively low hazards of dying due to CML in older age result in small absolute numbers. It appears to be conclusive that blasts in PB influence OS probabilities and CIM due to CML, as blasts in PB became also part of the Sokal and the Euro Score, both developed at times when OS probabilities were much lower, with most CML patients actually dying of CML. All findings will be checked in independent patient data. Disclosures: Pfirrmann: Novartis: Consultancy. Saussele:Pfizer: Honoraria; BMS: Honoraria, Research Funding, Travel, Travel Other; Novartis: Honoraria, Research Funding, Travel Other. Baccarani:Novartis: Research Funding. Lindörfer:Novartis: Research Funding. Hoffmann:Novartis Oncology: Research Funding. Castagnetti:Novartis: Consultancy, Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria. Hehlmann:Novartis: Research Funding.

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Huang, Hongmei, Ling Huang, Guangping Feng, Suhua Wang, Yue Wang, Jinling Liu, Nan Jiang et al. « Molecular Mapping of the New Blast Resistance Genes Pi47 and Pi48 in the Durably Resistant Local Rice Cultivar Xiangzi 3150 ». Phytopathology® 101, n^o 5 (mai 2011) : 620–26. http://dx.doi.org/10.1094/phyto-08-10-0209.

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The indica rice cultivar Xiangzi 3150 (XZ3150) confers a high level of resistance to 95% of the isolates of Magnaporthe oryzae (the agent of rice blast disease) collected in Hunan Province, China. To identify the resistance (R) gene(s) controlling the high level of resistance in this cultivar, we developed 286 F9 recombinant inbred lines (RILs) from a cross between XZ3150 and the highly susceptible cultivar CO39. Inoculation of the RILs and an F2 population from a cross between the two cultivars with the avirulent isolate 193-1-1 in the growth chamber indicated the presence of two dominant R genes in XZ3150. A linkage map with 134 polymorphic simple sequence repeat and single feature polymorphism markers was constructed with the genotype data of the 286 RILs. Composite interval mapping (CIM) using the results of 193-1-1 inoculation showed that two major R genes, designated Pi47 and Pi48, were located between RM206 and RM224 on chromosome 11, and between RM5364 and RM7102 on chromosome 12, respectively. Interestingly, the CIM analysis of the four resistant components of the RILs to the field blast population revealed that Pi47 and Pi48 were also the major genetic factors responsible for the field resistance in XZ3150. The DNA markers linked to the new R genes identified in this study should be useful for further fine mapping, gene cloning, and marker-aided breeding of blast-resistant rice cultivars.

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Billieux, J. « Inclusion du trouble lié aux jeux vidéos dans la CIM-11 : Réalité clinique ou pathologisation de la vie quotidienne ? » French Journal of Psychiatry 1 (novembre 2018) : S24. http://dx.doi.org/10.1016/s2590-2415(19)30058-3.

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Zhu, Kun, Xiaodong Zhang, Guanzhou Chen, Xiaoliang Tan, Puyun Liao, Hongyu Wu, Xiujuan Cui, Yinan Zuo et Zhiyong Lv. « Single Object Tracking in Satellite Videos : Deep Siamese Network Incorporating an Interframe Difference Centroid Inertia Motion Model ». Remote Sensing 13, n^o 7 (29 mars 2021) : 1298. http://dx.doi.org/10.3390/rs13071298.

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Satellite video single object tracking has attracted wide attention. The development of remote sensing platforms for earth observation technologies makes it increasingly convenient to acquire high-resolution satellite videos, which greatly accelerates ground target tracking. However, overlarge images with small object size, high similarity among multiple moving targets, and poor distinguishability between the objects and the background make this task most challenging. To solve these problems, a deep Siamese network (DSN) incorporating an interframe difference centroid inertia motion (ID-CIM) model is proposed in this paper. In object tracking tasks, the DSN inherently includes a template branch and a search branch; it extracts the features from these two branches and employs a Siamese region proposal network to obtain the position of the target in the search branch. The ID-CIM mechanism was proposed to alleviate model drift. These two modules build the ID-DSN framework and mutually reinforce the final tracking results. In addition, we also adopted existing object detection datasets for remotely sensed images to generate training datasets suitable for satellite video single object tracking. Ablation experiments were performed on six high-resolution satellite videos acquired from the International Space Station and “Jilin-1” satellites. We compared the proposed ID-DSN results with other 11 state-of-the-art trackers, including different networks and backbones. The comparison results show that our ID-DSN obtained a precision criterion of 0.927 and a success criterion of 0.694 with a frames per second (FPS) value of 32.117 implemented on a single NVIDIA GTX1070Ti GPU.

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Recio, C., A. E. Fallick et J. M. Ugidos. « A stable isotopic (δ18O, δD) study of the late-Hercynian granites and their host-rocks in the Central Iberian Massif (Spain) ». Earth and Environmental Science Transactions of the Royal Society of Edinburgh 83, n^o 1-2 (1992) : 247–57. http://dx.doi.org/10.1017/s0263593300007938.

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ABSTRACTStable isotopic ratios (mainly 18O/16O, but also D/H) have been measured for the three most important types of late-Hercynian granites, and their hosts, in the western area of the Central Iberian Massif (CIM), Spain. These granites are amphibole-bearing biotite granites, biotite granites and cordierite-bearing biotite granites. No intrusive relationships have been observed among them; the contact of each granite with the others is always gradational. Host-rocks are Precambrian/Cambrian metasediments, ranging from low-grade schists to migmatites (nebulites).Whole-rock δ18OSMOW values are as follows: amphibole-bearing biotite granites 8·9 ± 0·58% (1σ, n = 17); biotite granites 9·0 ± 0·35% (1σ, n = 11); cordierite-bearing biotite granites 9·6 ± 0·24% (1σ, n = 21). δ18O values for nebulites, into which some of these granites were emplaced, are significantly higher, at 11·1 ± 0·58‰ (1σ, n = 13). The Precambrian to Cambrian shales gave an average value of δ18O = 11·9 ± l·23‰ (lδ, n = 5). Whole-rock oxygen isotope ratios indicate that the origin of the granites was in neither purely sedimentary/metasedimentary rocks nor pristine mantle melts. δ18O values close to 9·0‰ require a crustal protolith, having an important recycled component.Oxygen isotope results are compatible with the cordierite-bearing granites being generated by assimilation of nebulite-like material by a biotite granite magma. However, 18O/16O of mineral separates obtained from the three different granites and the nebulite indicate that isotopic equilibrium, if ever reached, has not been preserved. The modified isotopic equilibrium is attributed to fluid activity, but mineral-pair δ-δ plots suggest that the granite system behaved as a closed system, and that the fluid was deuteric (magmatic) in origin. This implies that if assimilation did happen, it occurred at a temperature higher than the closure temperature of the different minerals to isotopic exchange. In a δ18O vs δD plot, hornblende and biotite separates from the granites plot within the igneous field. A simple mesocrustal anatectic origin for the peraluminous late Hercynian granites of the western area of the CIM is difficult to sustain on the basis of the stable isotope data, consistent with other field, petrographic and geochemical evidence. Cordierite in the cordierite-bearing granites is not “restitic” from a deep source area, but rather is xenocrystic from the high-grade metamorphic country rock (nebulites).

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Piccione, Francesco, Antonio Cerasa, Paolo Tonin, Simone Carozzo, Rocco Salvatore Calabrò, Stefano Masiero et Lucia Francesca Lucca. « Electrophysiological Screening to Assess Foot Drop Syndrome in Severe Acquired Brain Injury in Rehabilitative Settings ». Biomedicines 12, n^o 4 (16 avril 2024) : 878. http://dx.doi.org/10.3390/biomedicines12040878.

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Background: Foot drop syndrome (FDS), characterized by severe weakness and atrophy of the dorsiflexion muscles of the feet, is commonly found in patients with severe acquired brain injury (ABI). If the syndrome is unilateral, the cause is often a peroneal neuropathy (PN), due to compression of the nervous trunk on the neck of the fibula at the knee level; less frequently, the cause is a previous or concomitant lumbar radiculopathy. Bilateral syndromes are caused by polyneuropathies and myopathies. Central causes, due to brain or spinal injury, mimic this syndrome but are usually accompanied by other symptoms, such as spasticity. Critical illness polyneuropathy (CIP) and myopathy (CIM), isolated or in combination (critical illness polyneuromyopathy, CIPNM), have been shown to constitute an important cause of FDS in patients with ABI. Assessing the causes of FDS in the intensive rehabilitation unit (IRU) has several limitations, which include the complexity of the electrophysiological tests, limited availability of neurophysiology consultants, and the severe disturbance in consciousness and lack of cooperation from patients. Objectives: We sought to propose a simplified electrophysiological screening that identifies FDS causes, particularly PN and CIPNM, to help clinicians to recognize the significant clinical predictors of poor outcomes in severe ABI at admission to IRU. Methods: This prospective, single-center study included 20 severe ABI patients with FDS (11 females/9 males, mean age 55.10 + 16.26; CRS-R= 11.90 + 6.32; LCF: 3.30 + 1.30; DRS: 21.45 + 3.33), with prolonged rehabilitation treatment (≥2 months). We applied direct tibialis anterior muscle stimulation (DMS) associated with peroneal nerve motor conduction evaluation, across the fibular head (NCS), to identify CIP and/or CIM and to exclude demyelinating or compressive unilateral PN. Results: At admission to IRU, simplified electrophysiological screening reported four unilateral PN, four CIP and six CIM with a CIPNM overall prevalence estimate of about 50%. After 2 months, the CIPNM group showed significantly poorer outcomes compared to other ABI patients without CIPNM, as demonstrated by the lower probability of achieving endotracheal-tube weaning (20% versus 90%) and lower CRS-R and DRS scores. Due to the subacute rehabilitation setting of our study, it was not possible to evaluate the motor results of recovery of the standing position, functional walking and balance, impaired by the presence of unilateral PN. Conclusions: The implementation of the proposed simplified electrophysiological screening may enable the early identification of unilateral PN or CIPNM in severe ABI patients, thereby contributing to better functional prognosis in rehabilitative settings.

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Ahsan, Muhammad Zahir. « A comprehensive report of the National Coordinated Varietal Trial (NCVT) of Cotton conducted during 2019-20 in National Cotton Varietal Testing Program ». International Journal of Cotton Research and Technology 2, n^o 1 (8 octobre 2020) : 23. http://dx.doi.org/10.33865/ijcrt.002.01.0353.

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One hundred and two cotton cultivars, developed by the different scientists were grouped in four sets and tested at six locations in Punjab, four locations in Sindh, three locations in Balochistan and one location in KPK to test the adaptability of seed cotton yield. The quantitative and qualitative analysis of Bt toxin of these cultivars were conducted at four designated labs. The results revealed highly significant differences among the cultivars for seed cotton yield per hectare. In Set-A top performance cultivar is Saim-102 (2519kgha-1) followed by the Tahafuz 12 (2350kgha-1), in set-B Rustram-11 (2655kgha-1) and BF-1 (2288kgha-1) perform best as compared to the other cultivars. In Set–C cultivar, NIAB-1011 (2604kgha-1) and GH-Uhad (2531kgha-1) out yield the all other cultivars and in Set-D cultivar, Bt-CIM-775 (2588kgha-1) and Sahara-Klean-5 (2508kgha-1) surpass the yield from other candidate cultivars. Overall top varieties in Punjab, Sindh, Balochistan and National level were Rustam-11 (2484kgha-1), Sahara-Klean-5 (2714kgha-1), Diamon-2 (3742kgha-1), GH-Hamaliya (2594kgha-1), Rustam-11 (2655kgha-1),The average trait purity for BG-I (Cry1Ac) was 25 to 100%, for BG-II (Cry1Ac and Cry2Ab) none of the variety observed positive and for BG-III (Cry1Ac, Cry2Ab and RR) trait purity was 57 to 100%.

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Liao, Hong, Xiaolong Yan, Gerardo Rubio, Steve E. Beebe, Matthew W. Blair et Jonathan P. Lynch. « Genetic mapping of basal root gravitropism and phosphorus acquisition efficiency in common bean ». Functional Plant Biology 31, n^o 10 (2004) : 959. http://dx.doi.org/10.1071/fp03255.

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Root gravitropism determines the relative distribution of plant roots in different soil layers, and therefore, may influence the acquisition of shallow soil resources such as phosphorus (P). Growth pouch and field studies were conducted to evaluate root gravitropism of common bean (Phaseolus vulgaris L.) in response to P deficiency and to detect quantitative trait loci (QTL) associated with this trait. A deep-rooted genotype, DOR364, was crossed with a shallow-rooted genotype, G19833, to obtain 86 F5.7 recombinant inbred lines (RILs). Root gravitropic traits were measured as basal root growth angle (BRGA), shallow basal root length (SBRL, basal root length in the top 0–3 cm of soil) and relative shallow basal root length (RSBRL, percentage of basal root length in the top 0–3 cm of soil relative to total basal root length). Large genetic variability for these traits was found in the parents and RILs, with BRGA ranging from –18.73 to 56.69º and SBRL ranging from 0.42 to 2.63 m per plant. The parents and six RILs with contrasting root gravitropism were further evaluated in the field, where root shallowness was significantly correlated with plant growth and P uptake. QTL were detected by single point analysis (SPA), interval mapping (IM) and composite interval mapping (CIM) techniques with a genetic map for the DOR364 × G19833 population consisting of 236 molecular markers. The IM / CIM QTL were detected among the 11 linkage groups of common bean, with 16 QTL controlling the above root traits and six QTL controlling P acquisition efficiency (PAE) in the field study. At least three of the root trait QTL were associated with QTL for PAE, suggesting that root gravitropic traits are associated with PAE and that QTL for these traits can be used to facilitate selection and breeding for higher P efficiency in common bean and other crops.

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Liao, Hong, Xiaolong Yan, Gerardo Rubio, Steve E. Beebe, Matthew W. Blair et Jonathan P. Lynch. « Corrigendum to : Genetic mapping of basal root gravitropism and phosphorus acquisition efficiency in common bean ». Functional Plant Biology 33, n^o 2 (2006) : 207. http://dx.doi.org/10.1071/fp03255_co.

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Résumé :

Root gravitropism determines the relative distribution of plant roots in different soil layers, and therefore, may influence the acquisition of shallow soil resources such as phosphorus (P). Growth pouch and field studies were conducted to evaluate root gravitropism of common bean (Phaseolus vulgaris L.) in response to P deficiency and to detect quantitative trait loci (QTL) associated with this trait. A deep-rooted genotype, DOR364, was crossed with a shallow-rooted genotype, G19833, to obtain 86 F5.7 recombinant inbred lines (RILs). Root gravitropic traits were measured as basal root growth angle (BRGA), shallow basal root length (SBRL, basal root length in the top 0-3 cm of soil) and relative shallow basal root length (RSBRL, percentage of basal root length in the top 0-3 cm of soil relative to total basal root length). Large genetic variability for these traits was found in the parents and RILs, with BRGA ranging from -18.73 to 56.69� and SBRL ranging from 0.42 to 2.63 m per plant. The parents and six RILs with contrasting root gravitropism were further evaluated in the field, where root shallowness was significantly correlated with plant growth and P uptake. QTL were detected by single point analysis (SPA), interval mapping (IM) and composite interval mapping (CIM) techniques with a genetic map for the DOR364 � G19833 population consisting of 236 molecular markers. The IM�/�CIM QTL were detected among the 11 linkage groups of common bean, with 16 QTL controlling the above root traits and six QTL controlling P acquisition efficiency (PAE) in the field study. At least three of the root trait QTL were associated with QTL for PAE, suggesting that root gravitropic traits are associated with PAE and that QTL for these traits can be used to facilitate selection and breeding for higher P efficiency in common bean and other crops.

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