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Littérature scientifique sur le sujet « Chronic pruritus »

Auteur : Grafiati

Publié le 11 janvier 2025

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Articles de revues sur le sujet "Chronic pruritus"

Zhai, Savage, Qiu, Jin, Valdes-Rodriguez et Mollanazar. « Chronic Pruritus Responding to Dupilumab—A Case Series ». Medicines 6, n^o 3 (29 juin 2019) : 72. http://dx.doi.org/10.3390/medicines6030072.

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Background: Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in treating a number of conditions including atopic dermatitis (AD) and asthma. Its success in reducing pruritus in AD has generated interest regarding its potential application in other pruritic conditions, such as chronic pruritus of unknown origin, uremic pruritus, and pruigo nodularis. Methods: In this retrospective analysis, we present a series of 20 recalcitrant pruritus patients seen at a tertiary center treated with off-label dupilumab at standard AD dosing. Results: Dupilumab was successful at reducing itch in all treated patients, leading to complete resolution in 12/20 patients and an overall mean NRSi reduction of 7.55. Dupilumab was well tolerated with no significant adverse effects. Conclusions: Our case series suggests dupilumab may be a safe and efficacious therapeutic option in several pruritic conditions and demonstrates the need for further studies to better ascertain its place in the pruritus treatment armamentarium.

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Tareen, Attiya, Irfan Ullah, Ammara Safdar, Hadia Yaqub Khan, Uzma Rajar et Habiba Yaqub Khan. « Generalized Pruritus : An Etiological Breakup of 700 patients presenting to dermatology opd of a local hospital. » BMC Journal of Medical Sciences 3, n^o 2 (13 janvier 2023) : 65–69. https://doi.org/10.70905/bmcj.03.02.049.

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Background: Pruritus is an itching sensation or a constant urge to itch over skin that may be localized in response to a local stimulus or generalized due to an underlying condition with or without presence of causative agent. It can be caused by dermatological or systemic conditions, iatrogenic or as a response to external substances such as parasites. Generalized pruritus may not be necessarily due to dermatological causes and systemic, neurologic, endocrinologic, and psychogenic conditions may have pruritus as a primary cutaneous manifestation. Skin conditions like Scabies, eczema and airborne dermatitis are commonly incriminated as reason for intense itching and so lab workup or clinical examination and history taking is often omitted, in our busy outdoors. Therefore, the purpose of this study is to rule out underlying common systemic diseases like hypothyroidism, diabetes mellitus and chronic renal and liver disease as cause of severe generalized pruritus. Objective: To identify the underlying cause of generalized pruritus in patients presenting to dermatology outdoor excluding pruritic dermatological diseases. Methodology: This is a cross-sectional observational study conducted on 700 patients from January 2018 to October 2021, in Fauji Foundation hospital Rawalpindi. Patients between the ages of 15 to 69 years visiting dermatology OPD of the department with complaints of generalized pruritus, who were recruited for the study after filling the consent form. Clinical investigations (Blood Cp, LFTS, RFTs, TFTs) and past medical history were taken to identify the underlying cause of pruritus was conducted and diagnoses were documented Only the patients who were having non dermatological causes were included in the study and the diagnoses were further categorized as idiopathic, systemic, endocrinological, neurogenic, psychogenic and drug induced. Results were compiled and analyzed using SPSS version 22. Results: The results of this study show that 700 participants with mean age of 47.39, out of which 110 were males and 590 were females had generalized pruritus. Out of them, 126 (19%) had pruritus due to chronic renal disease, 119(17%) had chronic liver disease, 63 (9%) had diabetes mellitus, 42 (6%) had paraneoplastic, 126(18%) senile pruritis, 35(5%) had cholinergic pruritus,21 (3%) iron deficiency anemia. 14(2%) had atopic dermatitis of elderly. Drug induced pruritus 56(8%). Conclusion: Pruritus without known pruritic dermatoses is a common presenting complaint in patients presenting to outdoors having one of the underlying systemic disease. Further work is needed to evaluate impact of pruritus on quality of life in these already diseased patients.

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Yosipovitch, Gil, et Jeffrey D. Bernhard. « Chronic Pruritus ». New England Journal of Medicine 368, n^o 17 (25 avril 2013) : 1625–34. http://dx.doi.org/10.1056/nejmcp1208814.

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Ghassan, Ban, Jaffar N. Jaffar Alalsaidissa, Ali J. Hashim Al-Saedi et Sabah N. Alawchi. « Relationship of Pruritus with Biochemical and Haematological Parameters in Haemodialysis Patients (A Single Center Study). » Journal of the Faculty of Medicine Baghdad 57, n^o 4 (3 janvier 2016) : 306–11. http://dx.doi.org/10.32007/jfacmedbagdad.574396.

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Background: Pruritus often constitutes a major problem for patients with end stage renal disease. The pathophysiological mechanism of chronic kidney disease -associated pruritus is poorly defined.Objectives: To evaluate the prevalence of uremic pruritus in dialysis patients and their correlation with the laboratory and clinical parameters in some Iraqi patients with chronic renal disease.Patients & methods: This analytic, descriptive, cross-sectional study was performed on 103 patients on haemodialysis. Blood urea, creatinine, calcium, phosphorus, alkaline phosphatase and parathyroid hormone were determined. Complete blood count was also performed.Results: Of the 103 patients included in the study the, 79 patients (76.7%) had pruritus of whom, 27 (34.1%) had mild pruritus, 30 (38%) had moderate and 22 (27.9%) had severe pruritus. No significant association (p> 0.05) was found between pruritus and each of age and haemodialysis duration. There was no significant difference (p > 0.05) in the urea, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone, hemoglobin, hematocrit, white blood cells, neutrophils, eoisinophils, basophils mean values among patients who had no pruritus, mild, moderate and severe pruritus. A significant positive correlation (p > 0.05) was found between severity of pruritus in pruritic patients and each of age, hemoglobin and hematocrit levels.Conclusion: Our study showed that age, hemoglobin and hematocrit levels had a significant positive correlation with the severity of pruritus in pruritic patients.

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Kupsa, Romana, Alexandra Gruber-Wackernagel, Angelika Hofer, Franz Quehenberger, Peter Wolf et Franz J. Legat. « Narrowband-ultraviolet B vs Broadband-ultraviolet B in Treatment of Chronic Pruritus : A Randomized, Single-blinded, Non-inferiority Study ». Acta Dermato-Venereologica 103 (26 juin 2023) : adv9403. http://dx.doi.org/10.2340/actadv.v103.9403.

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Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g. in end-stage renal disease, broadband-ultraviolet B is recommended, but narrowband-ultraviolet B has also shown efficacy in reducing pruritus. This randomized, single blinded, non-inferiority study investigated the effects of narrowband-ultraviolet B compared with broadband-ultraviolet B. Patients with chronic pruritus were treated with either broadband- or narrowband-UVB 3 times a week for 6 weeks and clinical response was monitored. Pruritus, sleep disturbance, and the patients’ subjective overall response to treatment were evaluated by the patients on a visual analogue scale (0–10). Skin excoriations were evaluated by investigators on a 4-point scale (0–3). Both phototherapeutic modalities showed significant antipruritic activity (itch reduction 48% and 66.4%, respectively) by broadband-ultraviolet B and narrowband-ultraviolet B. Narrowband-ultraviolet B proved to be not inferior to broadband-ultraviolet B in treating pruritus in patients with chronic pruritus, assuming a 20% non-inferiority margin.

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Smith, Payton. « Treating Chronic Pruritus : Are We at the Threshold of a Breakthrough ? » SKIN The Journal of Cutaneous Medicine 8, n^o 4 (23 juillet 2024) : 1711–13. http://dx.doi.org/10.25251/skin.8.4.11.

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Chronic pruritis, characterized by persistent itchiness lasting more than six weeks, affects up to 15% of the population, significantly impairing quality of life. Despite its prevalence and impact, there is an absence of FDA-approved medications specifically for the treatment of chronic pruritus, highlighting a significant unmet need in dermatology. Advancements in dermatologic medications, however, including the development of biologics and Janus kinase (JAK) inhibitors, signal potential breakthroughs in pruritus management through a radically different mechanism of action that focuses on their effect on the nervous system. Currently, the most commonly utilized treatments for pruritis are sedating antihistamines, which have been largely ineffective for non-histamine-induced itch, underscoring the necessity for novel approaches. This editorial reviews key studies and clinical trials with a particular focus on cases of prurigo nodularis, where itch serves as the primary pathology rather than just a symptom. The effectiveness of dupilumab in phase III trials for treating prurigo nodularis, independent of its effects on dermatitis or atopic background, alongside the success of JAK inhibitors in managing chronic idiopathic pruritus, indicates a shift towards therapies that directly and specifically target itch nerve pathways instead of indirectly via immune system modulation or sedation. These developments suggest that significant progress may be on the horizon for treating chronic itch, providing hope for those suffering from pruritis, the number one cause of misery in dermatology.

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Yokoyama, Tomoaki. « Chronic Generalized Pruritus ». New England Journal of Medicine 386, n^o 6 (10 février 2022) : e12. http://dx.doi.org/10.1056/nejmicm2114503.

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Smucker, Joanne, Louis Portas et Joslyn S. Kirby. « Overevaluating Chronic Pruritus ». JAMA Internal Medicine 175, n^o 6 (1 juin 2015) : 895. http://dx.doi.org/10.1001/jamainternmed.2015.1041.

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Haq, Mazhar Ul, Rahmat Ali Khan, Najamud Din, Raza Muhammad Khan et Sultan Zafar. « The Epidemiology of Chronic Kidney Disease-Related Pruritus and its Effect with Sleep Quality in Hemodialysis Patients in Pakistan A Cross-Sectional Study ». Pakistan Journal of Medical and Health Sciences 16, n^o 8 (31 août 2022) : 957–59. http://dx.doi.org/10.53350/pjmhs22168957.

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A glomerular filtration rate of less than 60 ml/min/1.73 m2 for more than three months is the medical definition of chronic kidney disease (CKD) caused by damaged kidneys. The incidence of chronic kidney disease, which can be fatal if left untreated, has been rising for the past 30 years. An unpleasant condition, Pruritus due to chronic renal disease causes itching and decreases the quality of sleep. This study aims to examine the factors associated with Pruritus in CKD patients on maintenance hemodialysis and their impact on sleep quality. Duration and Place: Since 01/01 2019 and ending in 30/06/2019 that year, I will be working as a Post graduate trainee Nephrology in the Nephrology Department at the Institute of Kidney Diseases in Peshawar. Methodology: The department of Nephrology Institute of kidney diseases provided 120 patients with the chronic renal illness. Patients with chronic kidney disease who experienced Pruritus and sleep disruption were included in the study, but those with rashes and Pruritus unrelated to CKD were not. All patients were questioned about their age, gender, typical sleeping habits, illness severity, poor sleep quality, and the location of any pruritus they experienced. Results: CKD-associated This is how pruritis was dispersed: Eighty-one Percent of patients were older than 90, while the remaining 24 percent were younger. Only 43% of those diagnosed with Pruritus reported it affecting their ability to sleep, while 57% reported no such disruptions; also, only 31% of those diagnosed were female, and 74% were male. About 56 percent of those suffering from Pruritus have it quite seriously, whereas 44 percent do not. 62% of Pruritus people experience it on their trunks, compared to 38% elsewhere. A high degree of Pruritus was associated with the female gender, affected body parts, and lack of sleep. Conclusion: Pruritus (sometimes called "uremic pruritus") is the most prevalent skin symptom among persons with ESRD. Despite the absence of evidence linking it to uremia, a significant connection exists in men over 45, causes sleep disruption, and predominates in the trunk. Keywords: CKD-Related Pruritus, Effect, Sleep Quality, Hemodialysis

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Ishii, N., T. Nishiyama, Y. Sugita, H. Nakajima et I. Aoki. « Pruritic papular eruption of the acquired immunodeficiency syndrome. » Acta Dermato-Venereologica 74, n^o 3 (1 mai 1994) : 219–20. http://dx.doi.org/10.2340/0001555574221223.

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We report a case of acquired immunodeficiency syndrome with pruritic papular eruption. The patient, a hemophiliac, presented with generalized pruritic, skin-colored papules and nodules. The chronic lesions were excoriated and hyper-pigmented. The eosinophil count was elevated, but IgE was normal. The lesions and pruritus responded only to ultraviolet B phototherapy. While the mechanism is not known, ultraviolet B phototherapy may provide relief of AIDS-related pruritus.

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Thèses sur le sujet "Chronic pruritus"

Roque, Cunha Ferreira Bárbara Isabel. « Prurit psychogène ». Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0058.

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Le prurit psychogène est un diagnostic distinct chez les patients souffrant de prurit chronique et concerne les patients sans dermatose primaire ou une affection systémique liée au prurit chez qui des facteurs psychogènes sont identifiés. Ces patients peuvent présenter un stress psychique, une dynamique psychosociale ou une psychopathologie qui pourraient être à l’origine du prurit. Le groupe français de psychodermatologie a proposé des critères pour le diagnostic : 3/3 obligatoires et au moins 3/7 optionnels. Alors que les classifications disponibles ne permettent pas d’identifier les caractéristiques psychologiques et la psychopathologie associées, aucune étude prospective n’a été réalisée jusqu’à présent sur ce sujet. Nous avons donc fait une étude avec des patients diagnostiqués avec un prurit psychogène, en les comparant avec des patients souffrant de prurit chronique dû à d’autres étiologies. Certaines caractéristiques psychosociales liées au prurit psychogène permettent de le différencier des autres types de prurit, en particulier, des scores plus élevés d’alexithymie, d’anxiété, d’expériences dissociatives, sur l’échelle de stress de Holmes et Rahe les derniers 24 mois et de certaines stratégies de coping dysfonctionnelles. L’analyse des données souligne l’importance de considérer la présence d’une dynamique psychologique liée au contexte socio-familial du patient, renforçant la pertinence d’une approche psychodermatologique appliquée au prurit chronique et permettant d’identifier cette population de patients, dont l’approche thérapeutique devrait donner la priorité à l’approche du lien entre cette dynamique psychosociale et l’évolution des symptômes
Psychogenic pruritus is a distinct diagnosis in patients with chronic pruritus which refers to patients without a primarydermatosis or systemic disorder related to pruritus in whom psychogenic factors are identified. These patients may present with psychological stress, a psychosocial dynamic and psychopathology that could be at the origin of pruritus. The French psychodermatology group has proposed criteriafor diagnosis : 3/3 mandatory and at least 3/7 optional. As the available classifications do not allow for the identification of associated psychological characteristics and psychopatholoy, no prospective studies have yet been conducted on this subject. A prospective study was performed on patients diagnosed with psychogenic pruritus, compraing themwith patients suffering from chronic pruritus due to other disorders. There are some psychosocial characteristics associated with psychogenic pruritus, allowing it to be differentiated from other types of chronic pruritus, in particular, higher scores of alexithymia, anxiety and dissociative experiences, as welle as higher scores on the Holmes and rabe stress scale the last 24 mo,nths and certain dysfunctional coping strategies. Analysis of the data underlines the importance of considering the rpesence of a psychological dynamic linked to the patient’s socio-familial context, reinforcing the relevanceof a psychodermatological approach applied to chronic pruritus, making it possible to identify this population of patients, whose therapeutic approach should give priority to addressing the link between these psychosocial dynamics and the evolution of symptoms

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Ikoma, Akihiko. « Painful stimuli evoke itch in patients with chronic pruritus : Central sensitization for itch ». Kyoto University, 2004. http://hdl.handle.net/2433/147466.

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Kossuth-Cabrejos, Stefano, Arquímedes M. Gavino-Gutiérrez et Wilmer Silva-Caso. « Factors associated with the severity of pruritus in patients with terminal chronic kidney disease undergoing hemodialysis in Lima, Peru ». Page Press Publications, 2020. http://hdl.handle.net/10757/655593.

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The objective of the study is to analyze the factors associated with the severity of pruritus in patients with terminal chronic kidney disease undergoing hemodialysis. The methodology used is based on a cross-sectional study in patients receiving hemodialysis at the Centro Nacional de Salud Renal. Severe pruritus was defined as a score on the visual analogue scale greater than or equal to 7, and the strength of association with the possible risk factors was assessed by calculating prevalence ratios. Regarding the results, 264 patients were included, 59.9% were male, with a mean time on hemodialysis of 10.26 ± 7.14 years. 75% experienced pruritus, of this group, 1 in 3 presented severe pruritus. Hyperphosphatemia and the use of antihistamines were associated with a higher prevalence of severe pruritus (RP 1.71, 95% CI 1.09-267 and RP 2.39, 95% CI 1.51-3.75, respectively). The positive serology for Hepatitis C Virus was described as a protective factor for presenting severe pruritus (RP 0.55, 95% CI 0.33 - 0.89). In conclusion, severe uremic pruritus is a frequent problem in patients with chronic terminal kidney disease who have hyperphosphatemia and treatment with antihistamines independently of the time they have been on hemodialysis.
Revisión por pares

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Nattkemper, Leigh. « MEDIATORS AND RECEPTORS OF CHRONIC ITCH IN PRIMATES AND HUMANS ». Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/360207.

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Biomedical Sciences
Ph.D.
Chronic itch has a significant impact on quality of life for millions of patients worldwide, on a level comparable to that of chronic pain. Yet, although there are a host of effective drugs available for pain, there are no therapies that specifically target chronic itch. Current experimental approaches to investigate the pathogenesis of chronic pruritus and to test novel therapeutic agents are largely limited to rodent models. However, rodent models display significant dermatological, neurophysiological, and immunological differences from humans with chronic itch. The disadvantages of the current rodent paradigms call for the design of a valid primate model of chronic itch. For four years, we have monitored scratching behavior in a primate colony (n=35) of Cynomolgus macaques (Macaca fascicularis) suffering from idiopathic chronic itch. By comparing molecular and genetic analyses of the primates’ skin to their quantified scratching behavior, we attempted to characterize the underlying mechanisms of chronic itch in this model. Furthermore, the expression of itch-related proteins was examined in both the primate model and in humans with pruritic diseases. The first aim of the study was to characterize the underlying molecular and genetic basis of chronic itch in the primate model. We were able to distinguish specific peripheral targets related to pruritus by correlating the genetic and protein expression results to the primates’ scratching severity. In Aim 1a, RNA-sequencing was performed on skin biopsies from the primates to identify differentially expressed genes in pruritic, lichenified versus non-pruritic, non-lichenified skin. These results were then correlated to the quantified primate scratching behavior. This led to the identification of over 400 genes that were differentially expressed in the skin based on scratching intensity. Many of these differentially expressed transcripts were associated with sensory nerve fibers, keratinocytes, mast cells, or lymphocytes. Selected genes that were overexpressed and correlated to itch intensity were then targeted for immunohistochemical and proteomic analysis in Aim 1b. Immunohistochemical examination of the primate skin biopsies revealed that histamine levels were not elevated in primates that exhibited increased scratching behavior. However, mast cells containing tryptase were significantly increased in the skin of primates with severe scratching as compared to primates with mild scratching. The increased levels of gastrin-releasing peptide and substance P in lichenified skin were also found to be correlated to the primates’ scratching behavior. Of note, transient receptor potential channels V1, V3, and A1 were increased in the epidermis of primate skin, but the numbers of TRPV1+ and TRPA1+ nerve fibers were not significantly different between lichenified and non-lichenified skin. Transcriptome analysis of the opioid receptors and their ligands showed that primates with severe scratching behavior had a significant imbalance between the µ- and κ-opioid receptors and ligands. The µ-opioids had upregulated gene expression, while the κ-opioids were downregulated. In Aim 2, to further characterize this primate model of chronic itch, we compared immunohistochemical results from the primate studies to human findings. Lesional and non-lesional skin biopsies from patients with atopic dermatitis, psoriasis, and cutaneous T-cell lymphoma underwent immunohistochemical analysis in order to reveal the similarities and differences between the primate model and different types of chronic itch in humans. As in the primate model, substance P was found to be increased in the skin of lesional atopic and psoriasis skin. Additionally, similar to primate skin, human atopic and psoriatic skin had high levels of tryptase and its receptor in the epidermis. While IL-31 was only slightly elevated in primates, patients with cutaneous T-cell lymphoma or atopic dermatitis showed a significant correlation between itch severity and IL-31 levels. In conclusion, our primate model displayed expression patterns of many endogenous pruritogens and receptors that were similar to those of humans with atopic dermatitis or psoriasis. While the primate model did not completely mimic these specific pruritic diseases, the overlap of pruritic components suggests a commonality of signaling pathways across several different chronic itch states. The similarity of this primate model to human disease offers the combined advantages of experimental modeling and long-term behavioral follow-up.
Temple University--Theses

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Searles, Mona. « Acupuncture in the control of chronic pruritus ». 2004. http://www.ocomlibrary.org/images/PDF/studentpapers/monasearles.pdf.

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Livres sur le sujet "Chronic pruritus"

Pathogenesis and Treatment of Chronic Pruritus. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03943-101-4.

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Bowker, Lesley K., James D. Price, Ku Shah et Sarah C. Smith. Skin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198738381.003.0023.

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This chapter provides information on the ageing skin, photoageing, cellulitis, other bacterial skin infections, fungal skin infections, chronic venous insufficiency, leg ulcers, management of venous leg ulcers, pruritus, pruritic conditions, blistering diseases, skin cancers and pre-cancers, and other skin lesions.

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Voinescu, Alexandra, Nadia Wasi Iqbal et Kevin J. Martin. Management of chronic kidney disease-mineral and bone disorder. Sous la direction de David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0118_update_001.

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In all patients with chronic kidney disease (CKD) stages 3–5, regular monitoring of serum markers of CKD-mineral and bone disorder, including calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25-hydroxyvitamin D, and alkaline phosphatase, is recommended. Target ranges for these markers are endorsed by guidelines. The principles of therapy for secondary hyperparathyroidism include control of hyperphosphataemia, correction of hypocalcaemia, use of vitamin D sterols, use of calcimimetics, and parathyroidectomy. of hyperphosphataemia is crucial and may be achieved by means of dietary P restriction, use of P binders, and P removal by dialysis. Dietary P restriction requires caution, as it may be associated with protein malnutrition. Aluminium salts are effective P binders, but they are not recommended for long-term use, as Aluminium toxicity (though from contaminated dialysis water rather than oral intake) may cause cognitive impairment, osteomalacia, refractory microcytic anaemia, and myopathy. Ca-based P binders are also quite effective, but should be avoided in patients with hypercalcaemia, vascular calcifications, or persistently low PTH levels. Non-aluminium, non-Ca binders, like sevelamer and lanthanum carbonate, may be more adequate for such patients; however, they are expensive and may have several side effects. Furthermore, comparative trials have failed so far to provide conclusive evidence on the superiority of these newer P binders over Ca-based binders in terms of preventing vascular calcifications, bone abnormalities, and mortality. P removal is about 1800–2700 mg per week with conventional thrice-weekly haemodialysis, but may be increased by using haemodiafiltration or intensified regimens, such as short daily, extended daily or three times weekly nocturnal haemodialysis. Several vitamin D derivatives are currently used for the treatment of secondary hyperparathyroidism. In comparison with the natural form calcitriol, the vitamin D analogue paricalcitol seems to be more fast-acting and less prone to induce hypercalcaemia and hyperphosphataemia, but whether these advantages translate into better clinical outcomes is unknown. Calcimimetics such as cinacalcet can significantly reduce PTH, Ca, and P levels, but they have failed to definitively prove any benefits in terms of mortality and cardiovascular events in dialysis patients. Parathyroidectomy is often indicated in CKD patients with severe persistent hyperparathyroidism, refractory to aggressive medical treatment with vitamin D analogues and/or calcimimetics. This procedure usually leads to rapid improvements in biochemical markers (i.e. significant lowering of serum Ca, P, and PTH) and clinical manifestations (such as pruritus and bone pain); however, the long-term benefits are still unclear.

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Chapitres de livres sur le sujet "Chronic pruritus"

Mettang, Thomas. « Chronic Kidney Diseases ». Dans Pruritus, 241–51. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33142-3_33.

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Mettang, Thomas. « Chronic Kidney Disease-Associated Pruritus ». Dans Pruritus, 166–75. London : Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-322-8_27.

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Pogatzki-Zahn, Esther, Manuel P. Pereira et Martin Tegenthoff. « Measurement of Sensory Function in Chronic Pruritus ». Dans Pruritus, 57–65. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33142-3_7.

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Stumpf, Astrid, et Bettina Pfleiderer. « Sex- and Gender-Specific Differences in Chronic Pruritus ». Dans Pruritus, 117–22. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33142-3_16.

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Steinke, Sabine, Christine Blome et Matthias Augustin. « Patient Needs and Treatment Goals in Clinical Care of Chronic Pruritus ». Dans Pruritus, 111–16. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33142-3_15.

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Zylicz, Zbigniew, et Małgorzata Krajnik. « Serotonin Reuptake Inhibitors and Other Antidepressants in the Treatment of Chronic Pruritus ». Dans Pruritus, 301–6. London : Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-322-8_47.

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Azimi, Ehsan, Ethan A. Lerner et Sarina B. Elmariah. « Pruritus in Chronic Kidney Disease ». Dans Dermatological Manifestations of Kidney Disease, 81–89. New York, NY : Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2395-3_7.

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Gram, W. Dunbar. « Pruritus, Atopic Dermatitis, and Pyoderma ». Dans Chronic Disease Management for Small Animals, 23–38. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119201076.ch2.

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Lester, Jenna, et Leslie Robinson-Bostom. « Pruritus and Other Dermatological Problems in Chronic Kidney Disease ». Dans Management of Chronic Kidney Disease, 287–95. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54637-2_21.

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Marin, Benjamin Gallo, Cathy M. Massoud et Leslie Robinson-Bostom. « Pruritus and Other Dermatological Problems in Chronic Kidney Disease ». Dans Management of Chronic Kidney Disease, 345–55. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-42045-0_23.

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Actes de conférences sur le sujet "Chronic pruritus"

Rallis, Efstathios, Eleni Sfyri et Vasiliki Kefala. « Etiology of chronic pruritus ». Dans 1st Conference of the Hellenic Scientific Society of Aesthetics. PHARMAKON-Press, 2024. http://dx.doi.org/10.61873/zefl9915.

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Pruritus is considered a very frequent symptom and defined as chronic when its duration is longer than 6 weeks. The prevalence and the etiology of chronic pruritus (CP) are associated with various factors such as, age, atopy, underly- ing diseases, ethnicity, climate and humidity, as well as access to local healthcare system. The CP significantly affects the patients’ quality of life. Over time, patients often report sleep and mood disorders, with a negative psycho-social impact. From skin to brain, pruritus transmission occurs via multiple pathways, which are regulated by numerous cells, mediators, and receptors. A complete history and careful clinical examination are the keys to the diagnostic approach and determining treatment steps. Dermatological examination is essential and sometimes, an extensive laboratory testing must be carried out. The complexity in the presentation of this symptom, its obscure pathophysiology and multifactorial etiology, and the absence of clearly defined therapeutic goals, make CP a diagnostic and therapeutic challenge.

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Sharma, Akanksha, Saritha Shamsunder, Geetika Khanna, Neeti Khunger et Vijay Zutshi. « Chronic vulval problems : A gynaecologist’s perspective ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685355.

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Introduction: Chronic vulval symptoms are common complaints in women seeking health care and can significantly interfere with a woman’s sexual function and sense of well being. Many practitioners feel diagnostically challenged, particularly by chronic or recurrent forms of vulval disease. The aim of this study was to assess the role of various diagnostic modalities in evaluation of chronic vulval symptoms. Methods: Between August 2012 and February 2014, 100 women presenting with chronic vulval symptoms (i.e. ≥ 3 months duration) were evaluated. All of them had a thorough clinical history taken including use of vulval washes and creams, a general and gynaecological examination. Patients having chronic vaginal discharge in addition had urethral, vaginal and cervical smear and culture. All women had a careful examination of the vulva with and without magnification. Vulval scrape cytology was taken after moistening the vulva with normal saline and stained by Pap stain. Colposcopy of the vulva was then carried out after applying 5% acetic acid and 1% toluidine blue dye. Vulval biopsy was taken from suspicious areas on colposcopy and further management was based on histopathology report. Results: The mean age of women in our study was 43.57 years (range 22-80 years.), 70% women were pre-menopausal and 30% were post-menopausal. The mean duration of symptoms was 1.625 years (range 6 months - 15 years) and atypical vulval hygiene practices (excessive washing with soaps) was used in 77% of women. The commonest presenting complaint was pruritus in 92% of women; visible lesions on vulva were seen in 20%, pain in 6% and burning sensation in vulva in 5% of women. The histopathology was abnormal in 77 patients; the most common histopathological finding was non-neoplastic epithelial disorders in 64 women {Squamous cell hyperplasia (n=52), Lichen Sclerosus et atrophicus (n=6), other dermatoses including lichen Planus (n=6)}. Vulvar Intra-epithelial Neoplasia (VIN) was seen in 6 patients, 5 were squamous type VIN and 1 was non-squamous type (Paget’s disease). Squamous cell carcinoma was seen in 3 patients; malignant melanoma, benign appendiceal tumor, angiofibroma and neurofibroma in 1 patient. Examination without magnification had sensitivity of 25.97% and with magnification was 29.87% and specificity was 100% for both of them. Cytology had sensitivity and specificity of 75.32% and 86.95% respectively and sensitivity and specificity of colposcopy was 77.92% and 17.39% respectively. Conclusion: Clinical examination with and without magnification had low sensitivity but were highly specific in diagnosing vulvar lesions. A normal vulval smear and colposcopy have a high negative predictive value and are very reassuring. Colposcopy and biopsy is the gold standard for diagnosis, however clinical examination with naked eyes and magnifying glass are invaluable and can diagnose most of the neoplastic lesions.

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Argentina, Fifa, Ramdani, M. Zulkarnain, Debby Hidayati Harahap et Citra Tresna Murti. « Association between Xerosis and Severity of Pruritus in Patients with Chronic Renal Failure Undergoing Hemodialysis at Dr. Mohammad Hoesin (RSMH) General Hospital Palembang, Indonesia ». Dans The 23rd Regional Conference of Dermatology 2018. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008154602310235.

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Wiraputranto, Maria Clarissa, Oktatika Pratiwi Agustinus, Tamarachiara Kuntjoro et Heryanto Syamsuddin. « Uremic Pruritus Characteristics in Hemodialysis Patients with Chronic Kidney Disease in Relation to Blood Urea Levels and Dialysis Adequacy at Jakarta Pelabuhan Hospital, Indonesia ». Dans The 23rd Regional Conference of Dermatology 2018. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008151000680072.

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Georgieva, F. G. « PRURITUS IN LICHEN SIMPLEX CHRONICUS : PSYCHOLOGY OR PHYSIOLOGY ». Dans The 4th Global Virtual Conference. Publishing Society, 2016. http://dx.doi.org/10.18638/gv.2016.4.1.745.

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Maia, Fernanda Pimentel Arraes, Eduarda Sousa Machado, Fabiana Germano Bezerra, Brenda Regio Garcia et Luiz Gonzaga Porto Pinheiro. « LIVER TRANSPLANTATION IN A FEMALE PATIENT WITH PREVIOUS HISTORY OF BREAST CANCER ». Dans XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1052.

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Bile duct injury is a complication of cholecystectomy and may lead the patient to develop secondary biliary cirrhosis (SBC), an irreversible damage to the liver parenchyma caused by the chronic interruption of bile flow. Clinically, cirrhosis manifests when 80% of the liver parenchyma is affected with symptoms like pruritus, jaundice, coagulopathy, and ascites in advanced stages. Liver transplantation is an option of the treatment for SBC, especially when its progression leads to liver failure but there are conditions that strongly contraindicate the procedure, such as an active extrahepatic malignancy. We report a situation in which a patient with breast cancer underwent a liver transplant with good results over 10 years of follow-up. We report a 63-year-old woman, retired, healthy until 2001, when she was submitted for a cholecystectomy. After 15 days, the patient underwent a bile duct reconstruction due to an iatrogenic lesion of the bile duct. After 5 years of asymptomatic, she began to present anorexia, weight loss, jaundice, choluria, and fecal acholia, being diagnosed with SBC. The treatment with endoscopic retrograde cholangiopancreatography and the placement of stents in the bile ducts was initiated with no success. Therefore, she was referred to the liver transplant clinic of the Hospital Universitário Walter Cantídio, placed in Fortaleza-Ceará. On admission, the patient presented a regular general condition, oriented, icteric (++/4), and slimmer. The physical examination showed a symmetric thorax with a palpable lump in the right breast. Cardiac and pulmonary auscultations were normal. The patient had plane, flaccid, painless abdomen, with the presence of incisional hernia with spleen and palpable bowel loops. The laboratory tests showed the following results: creatinine 0.4 mg/dL; international normalized ratio (INR) 1.68; total bilirubin 17.9 mg/dL, being classified as CHILD B MELD 23. The patient also underwent an upper digestive endoscopy that exhibited esophageal varices. The abdominal ultrasound (US) presented signs of chronic liver disease, splenomegaly, and dilated intrahepatic bile ducts. In this case, it was also requested a breast US that revealed a lump on the right breast, measuring 1.5×1.1 cm. Then, she was referred to a mastologist, who requested a mammogram that showed an irregular, spiky, and high-density lump in the upper side quadrant of the right breast, measuring 12 mm. It was requested for a positron emission tomography, whose results excluded the possibility of metastasis. Then, the patient was submitted to a breast quadrantectomy with axillary dissection and removal of five lymph nodes, with freeze biopsy, confirming breast cancer with free margins and sentinel lymph node research. Histopathology of the breast piece revealed grade 2 infiltrating ductal carcinoma of the right breast, measuring 1.8×1.5 cm with angiolymphatic invasion and metastasis to 1 axillary lymph node of 3 mm. Immunohistochemistry examination was positive for estrogen and progesterone receptors, with low Ki-67 and negative HER-2, subtypes of LUMINAL A breast carcinoma. She underwent hormonal treatment, and adjuvant chemotherapy was not indicated. Due to the high risk of mortality associated with SBC, the patient was released by oncology and, in a multidisciplinary meeting with the participation of surgeons, hepatologists, and radiologists, it was decided to include the patient on the liver transplant list, performed 2 months after breast cancer surgery. After 10 years, the patient was monitored by the liver transplant service without recurrence of breast disease and with good liver graft function, using immunosuppressive therapy with everolimus 3.5 mg/day.

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Chernysheva, E. S., O. V. Shundeva et A. I. Laponova. « PRURITIC DERMATOSES IN CERTAIN PARASITOSIS. THE USE OF CRYOGENIC THERAPY IN COMBINED TREATMENT ». Dans THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.513-519.

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Pruritic dermatosis is chronic persistent processes. The principal symptom is tormenting itchy sensation excruciating for patients affected. Medical treatment is often ineffective. Itchy skin may be caused by parasite invasions. Whether external or endogenic, they are highly toxic, which is important in pathogenesis. Therefore, it is necessary to exclude parasitosis in patients with itchy skin. Intoxications and allergic reactions caused by polypragmasy are also capable to cause itching. In total, 64 patients were examined. They underwent histocoprological analysis for helminthic infections. Of them, 41 patients were found to have mono- and polyinvasions and abnormal intestinal macro- and microbiome, which required specific therapy. In 13 patients, the cause was polypharmacotherapy. General cryogenic therapy was applied in 12 patients with generalized itching. Exposure of skin parasites to extreme law temperatures discontinues their life cycle. The effects of general cryogenic treatment result in itching elimination, reduced inflammation, pain attenuation and wound healing. The skin is an informative organ showing therapeutic efficacy when properly treated. Application of general cryogenic treatment as an etiologically focused method is especially prescribed against external parasite infections (such as scabies, dirofilariasis, Morgellons disease).

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Rapports d'organisations sur le sujet "Chronic pruritus"

Ghirozi, Isadora Bueloni, Rebeka Bustamante Rocha, Heloi Jose Stefani, Yasmin Luz Lima de Mesquita, Everton Bruno Castanha et Lais Lopes Almeida Gomes. Efficacy and safety of dupilumab for atopic dermatitis in children and adolescents. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, mai 2022. http://dx.doi.org/10.37766/inplasy2022.5.0160.

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Review question / Objective: Is dupilumab effective for treatment of children and adolescentes with moderate to severe atopic dermatitis? Does it improve SCORAD outomes? Does it reduce pruritus? Does it improve quality of life? Does improve sleep quality? Condition being studied: Atopic dermatitis is a common and chronic skin disease characerized by inflammation, pruritus and dryness of the skin. Diminished quality of life, sleeping problems and intense chronic pruritus are among the consequences faced by patients with atopic dermatitis, especially those with moderate to severe presentations of the disease.

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Wala, Kamila, et Jacek Szepietowski. Difelikefalin in the treatment of chronic kidney disease-associated pruritus : a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, mai 2022. http://dx.doi.org/10.37766/inplasy2022.5.0154.

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Review question / Objective: The objective of this study is to evaluate the clinical efficacy and safety as well as to summarize the current knowledge of difelikefalin in treatment of patients with CKD-aP based on the available clinical trials. Condition being studied: Chronic kidney disease-associated pruritus (CKD-aP), also known as uremic pruritus, is a condition that significantly reduces the quality of life of patients with end-stage renal disease. There were unmet needs in the treatment of this condition. Difelikefalin is a novel opioid agonist with high selectivity for kappa opioid re-ceptors (KOR) that has been shown to be effective in the treatment of this type of chronic pruritus.

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Wang, Jie, Xinwei Yang, Jianli Huang, Yihua Xu et Xianbo Wu. Efficacy and safety of Chinese herbal medicine in the treatment of chronic pruritus : a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, juin 2022. http://dx.doi.org/10.37766/inplasy2022.6.0103.

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