Bibliographies thématiques / Chitosan nanoparticle

Littérature scientifique sur le sujet « Chitosan nanoparticle »

Auteur : Grafiati
Publié le 14 mars 2023

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Articles de revues sur le sujet "Chitosan nanoparticle"

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Wang, Cheng, Hong Lin et Yu Yue Chen. « Study on the Preparation of Steady-State Chitosan Nanoparticle as Silk-Fabric Finishing Agent ». Advanced Materials Research 175-176 (janvier 2011) : 745–49. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.745.

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The chitosan nanoparticles can be prepared by ionotropic gelation method in dispersion system. Chitosan nanoparticle has advantages of both the chitosan and the nano particles, and so it has a wide application in the textile finishing field. In this paper, the effects of the concentration of TPP, Span-80, deposited time and pH value on the diameter distribution of the chitosan nanoparticles are discussed in order to obtain the optimized preparation technics of steady state chitosan nanoparticle. The results show that chitosan nanoparticles are successfully prepared by ionotropic gelation method. Under the optimized preparation technics, chitosan nanoparticles disperse homogeneously in the system and have a good steady state. The average diameter of chitosan nanoparticle in the dispersion system is 20.82nm. Compared with the ordinary silk fabric, the B. mori silk fabric treated with chitosan nanoparticle dispersion system has better deepen effect of reactive dyes. The chitosan nanopartilce dispersion system is helpful to improve the dye uptake and dye fixation of silk fabrics.
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Yang, Ming-Hui, Shyng-Shiou Yuan, Ying-Fong Huang, Po-Chiao Lin, Chi-Yu Lu, Tze-Wen Chung et Yu-Chang Tyan. « A Proteomic View to Characterize the Effect of Chitosan Nanoparticle to Hepatic Cells : Is Chitosan Nanoparticle an Enhancer of PI3K/AKT1/mTOR Pathway ? » BioMed Research International 2014 (2014) : 1–9. http://dx.doi.org/10.1155/2014/789591.

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Chitosan nanoparticle, a biocompatible material, was used as a potential drug delivery system widely. Our current investigation studies were the bioeffects of the chitosan nanoparticle uptake by liver cells. In this experiment, the characterizations of chitosan nanoparticles were measured by transmission electron microscopy and particle size analyzer. The average size of the chitosan nanoparticle was224.6±11.2 nm, and the average zeta potential was+14.08±0.7 mV. Moreover, using proteomic approaches to analyze the differential protein expression patterns resulted from the chitosan nanoparticle uptaken by HepG2 and CCL-13 cells identified several proteins involved in the PI3K/AKT1/mTOR pathway. Our experimental results have demonstrated that the chitosan nanoparticle may involve in the liver cancer cell metastasis and proliferation.
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Wang, Cheng, Hong Lin, Yu Yue Chen et Yan Hua Lu. « Preparation and Application of Low Molecular Weight Chitosan Nanoparticle as a Textile Finishing Agent ». Advanced Materials Research 796 (septembre 2013) : 92–97. http://dx.doi.org/10.4028/www.scientific.net/amr.796.92.

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Due to the advantages of both the chitosan and the nanomaterial, chitosan nanoparticle has a broad application in a lot of fields, such as medicine carrier, food process, cosmetics and agriculture protect. And there also appears a lot of research about chitosan nanoparticle in textile finishing in recent years. In former research, steady state chitosan nanoparticles were prepared by ionotropic gelation method in dispersion system. In this paper, in order to confirm the preparation of low molecular weight chitosan nanoparticle, it was also characterized by Fourier Transform Infrared (FT-IR) Spectrometry, X-ray diffraction (XRD) and Transmission Electron Microscope (TEM). Focusing on the application value, chitosan nanoparticles dispersion solution were used as one kind of textile finishing agent to modifyB.morisilk fabrics in order to realize the functionalization of silk fabrics. The wrinkle resistance and bacteria repellency of silk fabrics were tested in the paper. The results showed that chitosan nanoparticles were successfully prepared and confirmed accrording to the XRD, FT-IR and TEM tests. In addition, compared with the ordinaryB. morisilk fabric and theB. morisilk fabric treated with chitosan accordingly, theB. morisilk fabrics treated with chitosan nanoparticle dispersion system had better wrinkle resistance and bacteria repellency.
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Verma, Devendra Kumar, Rajdeep Malik, Jagram Meena et Rashmi Rameshwari. « Synthesis, characterization and applications of chitosan based metallic nanoparticles : A review ». Journal of Applied and Natural Science 13, no 2 (22 mai 2021) : 544–51. http://dx.doi.org/10.31018/jans.v13i2.2635.

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Chitosan as a natural biopolymer has been produced to be the important host for the preparation of metallic nanoparticles (MNPs) because of its excellent characteristics like:- good stabilizing and capping ability, biocompatibility, biodegradability, eco-friendly and non-toxicity properties. Chitosan can play a very important role for synthesis of metallic nanoparticles, as chitosan is a cationic polymer. It attracts metal ions and reduces them and also Capps and stabilizes. So basically chitosan can be responsible for the controlled synthesis of metallic nanoparticle. Chitosan has a very good chelating property. This property is due to its –NH2 and –OH functional groups. Size and shape of metallic nanoparticles are much affected by chitosan concentration, molecular weight, time of reaction, degree of acetylation of chitosan, pH of the medium, method of synthesis and type of derivative of chitosan etc. Metallic nanoparticles`s properties and applications are much associated with their size and shape. Optimization of the metallic nanoparticle size and shape has been the subject of curiosity for nanotechnology scientist. Chitosan can solve this problem by applying the optimization conditions. But a very little work is reported about: - how chitosan can affect the size and shape of metallic nanoparticles and how can it reduce metal salts to prepare metallic nanoparticle, stablilized in chitosan metrics. This is very first report as a review article highlighting the effect of chitosan on synthesis of metallic nanoparticles and optimization conditions. This review will also be beneficial for scientist working on food sensing application of nanoparticles. Various synthesis methods and applications of chitosan based metallic nanoparticles have also been reported in details.
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Akmaz, Solmaz, Esra Dilaver Adıgüzel, Muzaffer Yasar et Oray Erguven. « The Effect of Ag Content of the Chitosan-Silver Nanoparticle Composite Material on the Structure and Antibacterial Activity ». Advances in Materials Science and Engineering 2013 (2013) : 1–6. http://dx.doi.org/10.1155/2013/690918.

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The aim of this study is to investigate the antibacterial properties and characterization of chitosan-silver nanoparticle composite materials. Chitosan-silver nanoparticle composite material was synthesized by adding AgNO3and NaOH solutions to chitosan solution at 95°C. Different concentrations (0,02 M, 0,04 M, and 0,06 M) of AgNO3were used for synthesis. Chitosan-silver nanoparticle composite materials were characterized by Transmission electron microscopy (TEM), X-ray diffraction (XRD), ultraviolet (UV) spectrophotometer, and Fourier transform infrared (FTIR) spectrometer techniques.Escherichia coli,Acinetobacter baumannii,Staphylococcus aureus,Enterococcus faecalis,Pseudomonas aeruginosa, andStreptococcus pneumoniaewere used to test the bactericidal efficiency of synthesized chitosan-Ag nanoparticle composite materials. The biological activity was determined by the minimum bacterial concentration (MBC) of the materials. Antibacterial effect of chitosan-silver nanoparticle materials was increased by increasing Ag amount of the composite materials. The presence of small amount of metal nanoparticles in the composite was enough to significantly enhance antibacterial activity as compared with pure chitosan.
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Vifta, Rissa Laila, et Fania Putri Luhurningtyas. « Nanoparticle from Medinilla speciosa with Various of Encapsulating Agent and Their Antioxidant Activities Using Ferric Reducing Assay ». Indonesian Journal of Cancer Chemoprevention 11, no 1 (6 mars 2020) : 22. http://dx.doi.org/10.14499/indonesianjcanchemoprev11iss1pp22-29.

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Antioxidants are agents that can reduce free radicals. Parijoto fruit (Medinilla speciosa) contains flavonoids that could act as an antioxidant. However, those flavonoids are water-soluble and show low bioavailability. Nanotechnology is a potential approach to improve the bioavailability of flavonoids from Parijoto fruit. This study was conducted to determine the antioxidant activity of parijoto nanoparticles with variations of the chitosan, alginate, and chitosan/alginate encapsulants. Secondary metabolites of parijoto fruit were using the maceration method. The synthesis of parijoto nanoparticles was conducted using the ionic gelation method with chitosan, alginate, and chitosan/alginate encapsulation. Parijoto nanoparticle size and distribution were characterized using Particle Size Analyzer (PSA). The formation of nanoparticles in colloids was determined as a percent. The antioxidant activity of nanoparticle was evaluated using Ferric Reducing Antioxidant Power (FRAP) method using a UV-Vis spectrophotometer. Chitosan encapsulation produced nanoparticles with a size of 269.3 nm, pdI 0.372 and transmittance 99.379%. Alginate encapsulation produced a particle size of 366.4 nm, pdI 0.589 and transmittance 99.690%. The combination of chitosan/alginate encapsulants produced a particle size of 187.00 nm, pdI 0.239 and transmittance 99.894%. Parijoto nanoparticles obtained from chitosan, alginate, and chitosan/alginate encapsulant showed strong antioxidant powers indicated by IC50 values 2.442±0.047 ppm, 3.175±0.169 ppm and 2.115±0.045 ppm, respectively. Altogether, our study shows that parijoto nanoparticles are potent as antioxidant agents.Keywords: Alginate, antioxidant, chitosan, FRAP, Medinilla speciosa, nanoparticle
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Barbosa, Ana, Sofia Costa Lima et Salette Reis. « Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery ». Molecules 24, no 2 (18 janvier 2019) : 346. http://dx.doi.org/10.3390/molecules24020346.

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Polymeric nanoparticles based on fucoidan and chitosan were developed to deliver quercetin as a novel functional food. Through the polyelectrolyte self-assembly method, fucoidan/chitosan (F/C) nanoparticles were obtained with three different weight ratios (1/1, 3/1, and 5/1). The content of quercetin in the fucoidan/chitosan nanoparticles was in the range 110 ± 3 to 335 ± 4 mg·mL−1, with the increase of weight ratio of fucoidan to chitosan in the nanoparticle. Physicochemically stable nanoparticles were obtained with a particle size within the 300–400 nm range and surface potential higher than +30 mV for the 1F/1C ratio nanoparticle and around −30 mV for the 3F/1C and 5F/1C ratios nanoparticles. The 1F/1C ratio nanoparticle became larger and more unstable as the pH increased from 2.5 to 7.4, while the 3F/1C and 5F/1C nanoparticles retained their initial characteristics. This result indicates that the latter nanoparticles were stable along the gastrointestinal tract. The quercetin-loaded fucoidan/chitosan nanoparticles showed strong antioxidant activity and controlled release under simulated gastrointestinal environments (in particular for the 3F/1C and 5F/1C ratios), preventing quercetin degradation and increasing its oral bioavailability.
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Валентина Геннадьевна, Матвеева,, Тихонов, Борис Борисович, Стадольникова, Полина Юрьевна, Лисичкин, Даниил Русланович, Манаенков, Олег Викторович et Сульман, Михаил Геннадьевич. « OPTIMIZATION OF CHITOSAN NANOPARTICLES SYNTHESIS CONDITIONS ». Вестник Тверского государственного университета. Серия : Химия, no 3(49) (28 octobre 2022) : 13–20. http://dx.doi.org/10.26456/vtchem2022.3.2.

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В работе методом ионотропного гелеобразования синтезированы стабильные наночастицы хитозана. Изучены свойства образца хитозана - определены его степень дезацетилирования (83,7%), а также относительная и характеристическая вязкости его растворов. Определены размеры наночастиц и дзета-потенциал методом динамического рассеяния света. Проведено исследование влияния соотношений реагентов - хитозана и триполифосфата натрия на средний диаметр синтезированных частиц и дзета-потенциал. Получены спектры образцов наночастиц в области 400-800 нм, свидетельствующие об образовании агрегатов частиц при определенных соотношениях реагентов. The article describes the synthesis of stable chitosan nanoparticles by ionotropic gelation. The properties of the chitosan sample were studied. A degree of deacetylation was determined to be 83.7%. Moreover, the relative and intrinsic viscosity of chitosane solutions were estimated. Nanoparticle sizes and zeta potential wer determined by dynamic light scattering method. The effect of reagent ratios - chitosan and sodium tripolyphosphate - on the average diameter of synthesized particles and zeta-potential was studied. Spectra of nanoparticle samples were obtained in the region of 400-800 nm, indicating the formation of particle aggregates at certain ratios of reagents.
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Wahyuni, S., K. R. P. Wibowo, H. T. Prakoso, M. Bintang et Siswanto. « Chitosan-Ag nanoparticle antifungal activity against Fusarium sp., causal agent of wilt disease on chili ». IOP Conference Series : Earth and Environmental Science 948, no 1 (1 décembre 2021) : 012064. http://dx.doi.org/10.1088/1755-1315/948/1/012064.

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Abstract Chitosan is a polysaccharides compound derived from nature and has an amine group and a hydroxyl group that gives it unique physicochemical properties, which are polychationic and chelating agent. This shows that chitosan can be used as a stabilizer and reducer of Ag nanoparticles. Unlike other studies, chitosan that was used in this study was derived from Black Soldier Fly exuviae which has been through demineralization, deproteination, depigmentation, and deacetylation processes. This study aims to obtain an alternative environmentally friendly fungicide with Ag-chitosan nanoparticle formulation which has antifungal activity against Fusarium sp. that causes wilt disease in chili plants. We analysed particle size, functional group by FTIR, and antifungal test against Fusarium sp. on 1000, 750, 500, 250, and 100 ppm of chitosan-Ag nanoparticle. The chitosan-Ag nanoparticles have a particle size of 188.4 nm with a polydispersity index of 0.344. FTIR analysis showed that Ag+ ions are successfully grafted into the chitosan matrix. All the chitosan-Ag nanoparticle concentration tested showed significant results with negative and positive control, except the concentration of 100 ppm which is not significantly differ from negative control. The antifungal test showed a concentration of 750 ppm chitosan-Ag nanoparticles had a growth inhibition of 72.17%.
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Smith, Raven A., Rebecca C. Walker, Shani L. Levit et Christina Tang. « Single-Step Self-Assembly and Physical Crosslinking of PEGylated Chitosan Nanoparticles by Tannic Acid ». Polymers 11, no 5 (27 avril 2019) : 749. http://dx.doi.org/10.3390/polym11050749.

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Chitosan-based nanoparticles are promising materials for potential biomedical applications. We used Flash NanoPrecipitation as a rapid, scalable, single-step method to achieve self-assembly of crosslinked chitosan nanoparticles. Self-assembly was driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions; tannic acid served to precipitate chitosan to seed nanoparticle formation and crosslink the chitosan to stabilize the resulting particles. The size of the nanoparticles can be tuned by varying formulation parameters including the total solids concentration and block copolymer to core mass ratio. We demonstrated that hydrophobic moieties can be incorporated into the nanoparticle using a lipophilic fluorescent dye as a model system.
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Thèses sur le sujet "Chitosan nanoparticle"

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Zarate-Triviño, D. G., Acosta E. M. Valenzuela, E. Prokhorov, G. Luna-Bárcenas, Padilla C. Rodríguez et Molina M. A. Franco. « Chitosan-Gold Nanoparticle Composites for Biomedical Application ». Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35404.

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The aim of this work is to synthesize chitosan-gold nanoparticles films by direct chemical reduction of HAuCl4 in a chitosan solution and to investigate the influence of gold nanoparticles concentration on the structure of films, conductivity and healing effect on mice skin after surgery. Results obtained have shown that new chitosan-gold nanoparticle-collagen bionananocomposites demonstrated better healing effect on the mice skin after surgery than control performed on commercial TheraFormTM material. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35404
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Saner, Brandon. « Physiochemical and Antibacterial Properties of Quaternized Chitosan Nanoparticle-Surfactant Mixtures ». University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525440791263562.

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Patel, Nimitt G. « Fabrication and characterization of gold nanoparticle reinforced Chitosan nanocomposites for biomedical applications ». Thesis, Clarkson University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3636199.

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Chitosan is a naturally derived polymer, which represents one of the most technologically important classes of active materials with applications in a variety of industrial and biomedical fields. Polymeric materials can be regarded as promising candidates for next generation devices due to their low energy payback time. These devices can be fabricated by high-throughput processing methodologies, such as spin coating, inkjet printing, gravure and flexographic printing onto flexible substrates. However, the extensive applications of polymeric films are still limited because of disadvantages such as poor electromechanical properties, high brittleness with a low strain at break, and sensitivity to water. For certain critical applications the need for modification of physical, mechanical and electrical properties of the polymer is essential. When blends of polymer films with other materials are used, as is commonly the case, device performance directly depends on the nanoscale morphology and phase separation of the blend components. To prepare nanocomposite thin films with the desired functional properties, both the film composition and microstructure have to be thoroughly characterized and controlled.

Chitosan reinforced bio-nanocomposite films with varying concentrations of gold nanoparticles were prepared through a solution casting method. Gold nanoparticles (∼ 32 nm diameter) were synthesized via a citrate reduction method from chloroauric acid and incorporated in the prepared Chitosan solution. Uniform distribution of gold nanoparticles was achieved throughout the chitosan matrix and was confirmed by SEM images. Synthesis outcomes and prepared nanocomposites were characterized using TEM, SAED, SEM, EDX, XRD, UV-Vis, particle size analysis, zeta potential and FT-IR for their physical, morphological and structural properties. Nanoscale mechanical properties of the nanocomposite films were characterized at room temperature, human body temperatures and higher temperatures using instrumented indentation techniques. The obtained films were confirmed to be biocompatible by their ability to support the growth and proliferation of human tissue cells in vitro. Statistical analysis on mechanical properties and biocompatibility results, were conducted. Results revealed significant enhancement on both the mechanical properties and cell adherence and proliferation. The results will enhance our understanding of the effect of nanostructures reinforcement on these important functional polymeric thin films for potential biomedical applications.

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Han, Yi. « Development and Evaluation of Mucoadhesive Chitosan Nanoparticle-based Salmonella Vaccine for Oral Delivery in Broiler Birds ». The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587571015936815.

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Picone, Carolina Siqueira Franco 1983. « Formação de nanopartículas por associação de biopolímeros e surfactantes = Formation of nanoparticles by biopolymer - surfactant association ». [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254194.

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Orientador: Rosiane Lopes da Cunha
Texto em português e inglês
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-20T12:57:32Z (GMT). No. of bitstreams: 1 Picone_CarolinaSiqueiraFranco_D.pdf: 4074904 bytes, checksum: 1a2779daa118fabb35ba241a8f6bf16f (MD5) Previous issue date: 2012
Resumo: As nano partículas possuem grande potencial para a liberação controlada de bioativos, porém ainda são pouco exploradas na área de alimentos. Neste trabalho foi estudada a formação de nanopartículas a partir da autoagregação de surfactantes, associação surfactante-polissacarídeo e complexação eletrostática entre diferentes polissacarídeos, no caso, quitosana e gelana. A compreensão das interações moleculares responsáveis pela formação das partículas e o conhecimento das variáveis que afetam sua formação permitem predizer e controlar suas propriedades. Tais interações dependem fortemente das características de cada macromolécula, como flexibilidade, estado conformacional e densidade de cargas que são diretamente afetadas pelas condições físico-químicas do meio como pH, força iônica e temperatura. Por isso, este trabalho foi dividido em três etapas. (I) Inicialmente foi avaliado o comportamento em solução dos polissacarídeos utilizados posteriormente para a formação de complexos. Os efeitos do pH e da temperatura nas características reológicas e no estado conformacional de soluções puras de gelana e quitosana foram estudados. A agregação da gelana foi mais sensível às alterações do meio que a quitosana. (II) Na segunda etapa, nanopartículas foram formadas por autoassociação de polissorbatos na presença de quitosana. A influência do comprimento da cauda hidrofóbica do surfactante e do pH do meio nas propriedades das partículas foi estudada por espalhamento de luz, reologia, condutivimetria e microscopia de luz polarizada. O tamanho e estrutura das partículas formadas pelo surfactante de menor cadeia hidrofóbica foram mais favoráveis à associação com a quitosana. O pH do meio (3,0 ou 6,7) não influenciou de maneira significativa as características das partículas. O efeito da concentração de quitosana na estrutura e tamanho de partículas foi analisado. Maiores concentrações levaram a viscosidades mais elevadas, impedindo a agregação das micelas e formando partículas menores. (III) No terceiro estudo, nanopartículas foram obtidas pela complexação eletrostática de gelana e quitosana. Os efeitos da razão de concentração de cada polissacarídeo, do tempo de estocagem a 25 °C e da presença de um surfactante nãoiônico (polissorbato) no tamanho, carga e quantidade de partículas formadas foram avaliados. Devido à menor densidade de carga e flexibilidade da gelana, maior quantidade deste polissacarídeo foi necessária para obtenção de partículas neutras. De forma geral, as partículas apresentaram aumento de tamanho ao longo das primeiras 100 horas após o preparo e não foram observadas mudanças significativas das propriedades das partículas devido à adição de surfactante. O método de preparo das amostras também foi estudado. Partículas preparadas pela mistura das soluções de polissacarídeos em dois passos foram consideravelmente maiores que as preparadas pela mistura em uma única etapa. Este trabalho confirmou a possibilidade de formação de nanopartículas promissoras para a encapsulação de bioativos em alimentos a partir da associação de biopolímeros e surfactantes, cujas propriedades poderiam ser moduladas em função da composição e condições de processo
Abstract: Nanoparticles are promising vehicles for bioactive delivery, but their potential has not been fully explored by the food industry. This work studied the formation of nanoparticles by self-assembly of surfactants, polysaccharide-surfactant association, and electrostatic complexes formed by different polysaccharides, especially chitosan and gellan gum. The knowledge of molecular interactions and the variables that affect particle formation allows predicting and controlling the properties of nanoparticles. These interactions depend on the characteristics of each macromolecule such as conformation, charge density and flexibility, which are affected by the physicol-chemical properties of the solution, such as pH, ionic strength and temperature. This work was divided in three parts: (I) Firstly it was studied the behaviour of each polysaccharide alone. The influence of the pH and temperature on the rheological properties and structural conformation of the pure gellan and chitosan samples was determined. Gellan aggregation was more strongly affected by such variables than chitosan. (II) In the second part, nanoparticles were obtained by polysorbate-chitosan association. The effect of the length of surfactant tail and the solution pH on the particle properties was studied by dynamic light scattering, rheological and conductivity measurements and polarizing microscopy. The size and structure of nanoparticles composed by the shorter surfactant were more appropriated to chitosan assembly. The pH (6.7 or 3.0) did not affect significantly the particle properties. The effects of chitosan concentration on particle structure and size were studied. Greater chitosan concentration led to smaller particles due to the increase in viscosity values which prevented micelles aggregation. (III) In the third study nanoparticles were produced by electrostatic complexation of chitosan and gellan gum. Particle size, charge density, stability and complexes number were evaluated as a function of polysaccharide concentration, chitosan:gellan ratio and the presence of a non-ionic surfactant. Due to the stiffness and low charge density of gellan gum, a greater amount of such polysaccharide was necessary to obtain neutral particles. Overall particles showed an increase in size during 100 hours of storage at 25 °C, but no significant changes on particle properties were observed due to surfactant addition. The methodology of particle preparation was also evaluated. Particles prepared by 2 mixing steps were markedly larger than those prepared by mixing polysaccharides in a single step (all together). This work showed that it is possible to produce nanoparticles with promising application on bioactive delivery by biopolymer-surfactant association, since their properties could be modulated as a function of composition and process conditions
Doutorado
Engenharia de Alimentos
Doutor em Engenharia de Alimentos
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Rayasam, Revanth. « Oral delivery of insulin for diabetes therapy : the design, fabrication and characterisation of a modified-chitosan based nanoparticle system ». Thesis, Kingston University, 2017. http://eprints.kingston.ac.uk/41955/.

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A number of innovative techniques were developed for the extra-vascular delivery of insulin, of which oral delivery of insulin being one of the most active fields of study in pharmaceutics. Interest in this domain is due to two factors: the therapeutic potential of the approach and lack of delivery systems which demonstrate promising results for clinical implementation. Oral delivery of insulin is of a particular challenge due to highly evolved and complex barriers presented by the gastrointestinal tract (GIT). Long-term s.c. injections are invasive and are associated with major drawbacks such as pain, weight gain, hypoglycaemia, hyperinsulinemia, leading to low patient compliance and adherence. The present work aims to develop novel insulin-loaded chitosan (CS) and pegylated chitosan (CS-O-mPEG) based nanoparticles (NPs) and investigate them for potential colonic delivery. PEG-Chitosan was chemically conjugated using low molecular weight chitosan and mPEG-2000. Insulin loaded pegylated chitosan (CS-O-mPEG) NPs were prepared via the iontropic gelation technique by cross-linking with tripolyphosphate (TPP). The characteristics of the NPs i.e. particle morphology, particle size and zeta potential was evaluated. The effect of pH and the polymer:TPP wieght ratios on NP characteristics was also evaluated. An HPLC analytical method to quantify insulin was developed and validated. In vitro release and entrapment studies of the nanoparticles were conducted using the Franz diffusion cells. Prepared nanoparticle formulations were assessed for biocompatibility using the MTT (Tetrazolim dye) assay and permeability studies on the Caco-2 and MDCK monolayers. Successful CS-O-mPEG conjugation was confirmed by FTIR and 1H NMR spectroscopy. SEM revealed the spherical nature of CS and CS-O-mPEG NPs. A mean diameter ranging from 50 - 250 nm was recorded for the NPs. Characterisation of NPs for zeta potential was carried out for both the CS and CS-O-mPEG formulations. Particle size measurements for the NPs revealed size ranges between 110-250 nm, in accordance to the hydradynamic diameter measured by DLS. RP- HPLC analytical method was developed and validated according to ICH guidelines to quantify Insulin. The data showed presence of well-defined single insulin peak, being successfully recovered at retention time between 7.5 - 9 minutes. CS-O-mPEG NPs demonstrated maximum release in simulated intestinal fluids (SIF). There was some encouraging data obtained in regard to the biocompatibility studies for the prepared Insulin loaded NP formulations using MTT assay. Permeability studies were also conducted for the prepared NP formulations on Caco-2 and MDCK monolayers, revealing better permeation of insulin through the CS-O-mPEG NPs. Insulin-loaded NPs of CS and CS-O-mPEG were successfully formulated. CS-O-mPEG NPs demonstrated superior in vitro characteristics over the conventional CS NPs in terms of aqueous solubility, particle size, entrapment efficiency and drug release profile, In addition, permeation studies revealed that CS-O-mPEG NPs enabled a significantly higher insulin transfer across Caco-2 and MDCK cell monolayer models compared to the CS NPs making the former a promising candidate for oral delivery of insulin.
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Malli, Sophia. « Formulations multifonctionnelles pour le traitement des infections parasitaires cutanéo-muqueuses ». Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS043.

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Ce projet vise à proposer des nouveaux candidats médicaments pour lutter contre les infections parasitaires cutanéo-muqueuses qui représentent un problème de santé majeur. C’est notamment le cas de la Trichomonose urogénitale et la leishmaniose cutanée.Malheureusement, l’administration systémique de première intention par le métronidazole (MTZ) pour traiter la trichomonose urogéntitale occasionne des problèmes de résistances et des effets secondaires indésirables. Ainsi, nous avons développé de nouvelles stratégies thérapeutiques en ciblant à la fois les mécanismes pharmacologiques et physiques de l’infection par Trichomonas vaginalis. Après avoir réussi à augmenter la solubilité apparente du MTZ dans l’eau en utilisant une beta-cyclodextrine méthylée, nous l’avons formulé dans un hydrogel thermosensible et mucoadhésif composé de pluronic® F127 et d’un biopolymère cationique et mucoadhésif, le chitosane. Cette formulation est spécifiquement adaptée à une application topique tout en offrant un contrôle de la libération du MTZ et une réduction de son passage systémique à travers la muqueuse vaginale. La viscosité élevée de l’hydrogel à température corporelle nous a conduit à étudier son effet sur la mobilité du protozoaire Trichomonas vaginalis. Il s’agit d’une stratégie physique d’immobilisation du parasite en parallèle à la chimiothérapie par le MTZ. Le suivi des trajectoires des parasites par vidéo-microscopie a montré la capacité de l’hydrogel seul ou en association avec le chitosane à immobiliser complètement T. vaginalis et à inhiber son attachement à la muqueuse. Ces évaluations ont été réalisées chez la souris. Cependant, le chitosane seul n’a pas permis d’immobilier les parasites et n’a pas montré une activité anti-T. vaginalis propre. Dans ce contexte, nous nous sommes inspirés des travaux antérieurs menés par notre équipe sur le développement de formulations à base de chitosane, et plus particulièrement des nanoparticules (NPs) composées de poly(isobutylcyanoacrylates) recouvertes de chitosane. Ces NPs ont une activité trichomonacide propre, même sans rajouter des substances actives, alors que des NPs sans chitosane étaient inactives. Nous avons étudié le mécanisme d’action et nous avons montré une meilleure internalisation des NPs lorsqu’elles étaient recouvertes de chitosane. Ces NPs ont provoqué des altérations morphologiques drastiques de la membrane du parasite. Cette activité pourrait être due en partie à l’interaction électrostatique entre la surface de T. vaginalis chargée négativement et les NPs recouvertes de chitosane cationique.Dans le but d’élargir le champ des applications de ces NPs à d’autres parasites, nous nous sommes intéressés à l’évaluation de leur effet anti-leishmanien vis-à-vis de Leishmania major. En effet, le chitosane connu pour ces propriétés cicatrisantes nous a paru particulièrement adapté pour cette pathologie. Nous avons ainsi montré in vitro et in vivo que les NPs recouvertes de chitosane avaient une activité anti-L. major propre, sans ajouter de substances actives. Dans un deuxième temps, nous avons décidé de nous orienter vers des particules de formes allongées et d’évaluer leur activité anti-leishmanienne. Ces particules appelées « plaquettes » sont constituées d’assemblages de chitosane hydrophobisé avec l’acide oléique et l’alpha-cyclodextrine dans l’eau. Cette stratégie nous a paru intéressante pour améliorer l’interaction des plaquettes avec la membrane de L. major, vue que ces parasites sont également de morphologie non-sphérique. Les résultats histologiques et immunohistochimiques des lésions cutanées ont montré une diminution significative du granulome inflammatoire et une réduction de la charge parasitaire par rapport à l'amphotéricine B seule utilisée comme référence.En conclusion, au cours de cette thèse, plusieurs formulations ont été développées et ont montré des efficacités biologiques en agissant sur des mécanismes pharmacologiques et/ou physiques des parasites
This project aims at developing new therapeutic strategies against parasitic muco-cutaneous infections such as urogenital trichomonosis and cutaneous leishmaniasis which still represents a major health problem worldwide.Unfortunately, metronidazole (MTZ) is a first-line systemic treatment for urogenital trichomoniasis that causes resistance and side effects. We have thus developed new strategies by acting on both the pharmacological and the physical mechanisms of Trichomonas vaginalis infection. After a successfull increase of the apparent solubility of MTZ in water using a methylated -cyclodextrin, we formulated it in a thermosensitive and mucoadhesive hydrogel composed of pluronic® F127 and a cationic and mucoadhesive biopolymer, chitosan. This formulation is specifically adapted for topical application providing a control of MTZ release and reduction of its systemic passage through the vaginal mucosa.Then, the ability of the high viscosity hydrogel to immobilize T. vaginalis was investigated by video-microscopy. Monitoring the trajectories of each parasite by multiple particle tracking showed the ability of the hydrogel alone or in combination with chitosan to completely immobilize T. vaginalis and to inhibit parasite attachment to the mucosa. These evaluations were performed on mice experimental model. However, chitosan alone did not allow parasite immobilization and did not show any anti-T. vaginalis activity. In this context, we were inspired by previous works conducted by our team on the development of formulations based on chitosan, and more particularly nanoparticles (NPs) composed of poly(isobutylcyanoacrylates) coated with chitosan. These NPs have their own trichomonacidal activity, even without adding active substances, while NPs without chitosan were inactive. Investigated of the mechanism of the activity showed better internalization of NPs when coated with chitosan. These NPs caused drastic morphological alterations on the parasite membrane. This activity could be due to the electrostatic interaction between negatively charged T. vaginalis surface and cationic chitosan coated NPs.In order to broaden the applications of these NPs to other parasites, we were interested in evaluating the anti-L. major activity of NPs coated or not with chitosan. Indeed, chitosan known for its healing properties could be particularly adapted for this pathology. We thus showed in vitro and in vivo that NPs coated with chitosan had intrinsic anti-L. major activity without adding any drug. In a second step, we decided to design chitosan elongated particles and to evaluate their anti-leishmanial activity. These particles called "platelets" are composed of chitosan hydrophobically-modified with oleic acid and cyclodextrin in water. This strategy could be interesting to improve the interaction of platelets with the L. major membrane, as these parasites had also non-spherical morphology. The histological and immunohistochemical results of skin lesions showed a significant decrease in inflammatory granuloma and a reduction in parasitic load compared with amphotericin B alone, used as a reference.In conclusion, during this thesis, several formulations were developed and showed biological activities by acting on pharmacological and/or physical mechanisms of the parasites
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Bissonnette, Caroline. « Biodegradable Polylactide-co-Glycolide-Chitosan Janus Nanoparticles for the Local Delivery of Multifaceted Drug Therapy for Oral Squamous Cell Carcinoma Chemoprevention ». The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1590751959128008.

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Yoshida, Jony Takao. « Nanopartículas de quitosana como veículo de vacinação contra a hepatite B via nasal ». Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9134/tde-15032013-163603/.

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A imunização por via nasal pode representar uma alternativa as imunizações intramusculares, pois a aplicação por essa rota não é invasiva e há fácil acesso da vacina à mucosa. Além disso, a mucosa nasal apresenta diversas características que podem favorecer a imunização, por exemplo, há uma grande área superficial altamente vascularizado disponível para a absorção dos antígenos. Outra característica fundamental é a capacidade da mucosa de responder a antígenos, através das células imunocompetentes presentes, como as células M e dendríticas. Apesar disso, outros métodos podem ser empregados para melhorar absorção e disponibilidade dos antígenos pela mucosa, como a utilização de polímeros biodegradáveis. Entre estes, a quitosana é um biopolímero, derivado da desacetilação da quitina, que tem como principal característica, a possibilidade de estrutura-los em nanopartículas. Outra característica importante é sua propriedade catiônica a qual possibilita a sua ligação a proteínas e também à mucosa, que provoca maiores taxas de retenção de antígenos pela mucosa. Assim, neste trabalho, foi avaliado a imunogenicidade da inoculação do antígeno de superfície da hepatite B (HBsAg), via mucosa nasal em camundongos, os quais produziram anticorpos IgG contra HBsAg, apresentaram aumento da secreção de IgA pela mucosa nasal, e também ao avaliar a resposta de citocinas em células RAW 264.7, houve secreção de TNF-α .
The nasal vaccination is not invasive since its do not require needles for your application and your administration for is easy, thus the immunization via nasal route could be an alternative to intramuscular immunizations. Furthermore, the nasal mucosa has several characteristics like highly vascularized surface area available for absorption of antigen that could elicited the mucosal immune response caused by the competents cell available on the mucosal tissue. Nevertheless, other methods can be employed to improve absorption and availability of antigens to the mucosa, such as the use of nanoparticles of chitosan. Chitosan is a biopolymer product of deacetylation reaction of chitin, that has as main characteristic, the moldability, which enables the production of nanoparticles and its cationic property which allows its binding to proteins and also to the mucosa, which would lead to higher rates of absorption of antigens through the nasal mucosa. Thus, this work investigated the immunogenicity of the administration nanoparticles of chitosan with the surface anti-gen of hepatitis B (HBsAg) via the nasal mucosa in mice, which show levels of IgA in nasal lavages and serum IgG, as well as cytokines such as TNF-α released by RAW 264.7 cells of mice.
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Cover, Natasha Faith. « A Novel Device and Nanoparticle-Based Approach for Improving Diagnosis and Treatment of pelvic Inflammatory Disease ». Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4020.

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Pelvic Inflammatory Disease (PID) is one of the most common causes of morbidity in women. PID is a polymicrobial infection of the female reproductive tract, and is associated with pelvic pain, abnormal uterine bleeding, and tubal damage that can lead to ectopic pregnancies and infertility. It is curable but the effects of PID can be permanent if not properly diagnosed and treated. PID presents as a spectrum of disease and is often missed at early stages; even acute PID can be difficult to diagnose, as there is no single conclusive diagnostic test. Currently, PID is identified and treated syndromically because pelvic pain is the only consistent clinical finding. The Center for Disease Control and Prevention (CDC) recommends doxycycline, a broad-spectrum antibiotic, for treatment but doxycycline can cause gastrointestinal irritation and local inflammation leading to an incomplete treatment. Most cases of PID are polymicrobial infections of the tubes and endometrium, which are not accessible to culture due to the difficulty of procuring samples above the naturally contaminated vagina and distal cervix. Given the difficulty of properly diagnosing PID and the limitations and side effects of the current treatments, there is an urgent need for new approaches for improving the accuracy for diagnosis and treatment of PID. We propose a new and practical approach to collect sterile specimen samples from the endometrium for more accurate PID diagnosis, and to treat the reproductive tract locally using doxycycline-loaded nanoparticles. The proposed research presents a novel sterile uterine sampler cover (SUSC) device that can safely and effectively collect uncontaminated specimen samples from the uterus, and also deliver nano-encapsulated drugs directly to the site of infection. The analysis of uncontaminated endometrium samples is expected to provide an understanding of uterine flora in symptomatic and asymptomatic women, and will lead to the identification of infective microbes in symptomatic women for pathogen-specific treatment. The use of nano-encapsulated doxycycline will enable localized drug delivery to lower drug dosage and minimize side effects for the patient. The doxycycline-loaded nanoparticles are characterized and evaluated based on their drug release properties, size distribution, and tissue response in vitro. This research will lead towards a more effective approach for the diagnosis and treatment of PID while freeing women from prolonged systemic treatments and their adverse effects. Moreover, this research will increase our understanding of the uterine biome under various hormonal and pathologic conditions, in symptomatic and asymptomatic women.
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Livres sur le sujet "Chitosan nanoparticle"

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Porous structure and adsorption behaviours of chitosan. Hauppauge, N.Y : Nova Science Publishers, 2010.

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Gupta, Abhishek. Chitosan Nanoparticles. Arcler Education Inc, 2017.

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Gama, Miguel, Paula Pereira, Vera Carvalho et Reinaldo Ramos. Chitosan Nanoparticles for Biomedical Applications. Nova Science Publishers, Inc., 2010.

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Chapitres de livres sur le sujet "Chitosan nanoparticle"

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Lee, Dongwon, et Shyam S. Mohapatra. « Chitosan Nanoparticle-Mediated Gene Transfer ». Dans Methods in Molecular Biology, 127–40. Totowa, NJ : Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-237-3_8.

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de Oliveira, André Luiz Barros, Francisco Thálysson Tavares Cavalcante, Katerine da Silva Moreira, Paula Jéssyca Morais Lima, Rodolpho Ramilton de Castro Monteiro, Bruna Bandeira Pinheiro, Kimberle Paiva dos Santos et José Cleiton Sousa dos Santos. « Chitosan Nanoparticle : Alternative for Sustainable Agriculture ». Dans Nanomaterials and Nanotechnology, 95–132. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6056-3_4.

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Revathi, G., S. Elavarasi et K. Saravanan. « Antidiabetic Activity of Drug Loaded Chitosan Nanoparticle ». Dans Drug Development for Cancer and Diabetes, 249–62. Includes bibliographical references and index. : Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-21.

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Jain, Shardool, et Mansoor Amiji. « Target-Specific Chitosan-Based Nanoparticle Systems for Nucleic Acid Delivery ». Dans Chitosan-Based Systems for Biopharmaceuticals, 275–99. Chichester, UK : John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119962977.ch16.

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Vong, Long Binh, Nhu-Thuy Trinh, Van Toi Vo et Dai-Nghiep Ngo. « Chitosan Oligosaccharide-Based Nanoparticle Delivery Systems for Medical Applications ». Dans Chitooligosaccharides, 157–71. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92806-3_10.

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Malhotra, Meenakshi, Catherine Tomaro-Duchesneau, Shyamali Saha et Satya Prakash. « Intranasal Delivery of Chitosan–siRNA Nanoparticle Formulation to the Brain ». Dans Methods in Molecular Biology, 233–47. New York, NY : Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0363-4_15.

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Andersen, Morten Østergaard, Kenneth Alan Howard et Jørgen Kjems. « RNAi Using a Chitosan/siRNA Nanoparticle System : In Vitro and In Vivo Applications ». Dans Methods in Molecular Biology™, 77–86. Totowa, NJ : Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-295-7_6.

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Aslan, Burcu, Hee Dong Han, Gabriel Lopez-Berestein et Anil K. Sood. « Chitosan Nanoparticles ». Dans Encyclopedia of Nanotechnology, 525–31. Dordrecht : Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-017-9780-1_71.

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Peroulis, Dimitrios, Prashant R. Waghmare, Sushanta K. Mitra, Supone Manakasettharn, J. Ashley Taylor, Tom N. Krupenkin, Wenguang Zhu et al. « Chitosan Nanoparticles ». Dans Encyclopedia of Nanotechnology, 427–33. Dordrecht : Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_71.

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Akbuga, Julide, Suna Ozbas-Turan et Ceyda Ekentok. « Chitosan Nanoparticles in Gene Delivery ». Dans Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement, 337–51. Berlin, Heidelberg : Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47862-2_22.

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Actes de conférences sur le sujet "Chitosan nanoparticle"

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Musa, Nafisah, et Tin Wui Wong. « Nanoparticles-in-soft microagglomerates as oral colon-specific cancer therapeutic vehicle ». Dans 3rd International Congress of Engineering Sciences and Technology. Facultad de Ciencias de la Ingenierí­a y Tecnología, 2021. http://dx.doi.org/10.37636/recit.cicitec21.1.

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Polymeric nanoparticles can be conjugated with targeting ligand such as folate to elicit oral colon-specific drug delivery to treat colon cancer. Oral chemotherapy can be used as adjuvant, neo-adjuvant, or primary therapy. Nonetheless, oral cancer chemotherapeutics may experience premature drug release at the upper gastrointestinal tract due to the availability of a large specific dissolution surface area of nanoparticles leading to failure in colon cancer targeting. This study designed soft microagglomerates as carrier of nanoparticles to delay drug release. High molecular weight chitosan/pectin with covalent 5-fluorouracil/folate was processed into nanoparticles. Low molecular weight chitosan was spray-dried into nanoparticle aggregation vehicle. The soft agglomerates were produced by blending of nanoparticles and aggregation vehicle in specific weight ratios through vortex method. Adding aggregation vehicle promoted soft agglomeration with nanoparticles deposited onto its surfaces with minimal binary coalescence. Soft agglomerates prepared from 10:18 weight ratio of nanoparticles to nanoparticle aggregation vehicle using 1% chitosan solution concentration reduced the propensity of premature drug release of nanoparticles in the upper gastrointestinal region. Soft agglomerates reduced early drug release of cancer chemotherapeutics and was responsive to intracapsular sodium alginate coat to further sustain drug release. The soft microagglomerates are a viable dosage form in colon-specific drug delivery. Further study will focus on investigating intracapsular-coated soft agglomerates in vivo pharmacokinetics and pharmacodynamics behaviours with respect to local colorectal cancer.
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Cetin, Barbaros, Serdar Taze, Mehmet D. Asik et S. Ali Tuncel. « Microfluidic Device for Synthesis of Chitosan Nanoparticles ». Dans ASME 2013 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fedsm2013-16349.

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Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed.
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Fithriyah, Nurul Hidayati, et Erdawati. « Mechanical properties of paper sheets coated with chitosan nanoparticle ». Dans 4TH INTERNATIONAL CONFERENCE ON MATHEMATICS AND NATURAL SCIENCES (ICMNS 2012) : Science for Health, Food and Sustainable Energy. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4868781.

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Kim, Song-Bae, et Seung-Chan Lee. « Iron Oxide Nanoparticle-Chitosan Composites for Phosphate Removal from Water ». Dans The 3rd World Congress on Recent Advances in Nanotechnology. Avestia Publishing, 2018. http://dx.doi.org/10.11159/icnei18.103.

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« Synthesis of Aloe Vera Loaded Chitosan Nanoparticle with Ionic Gelling Method ». Dans 2019 Scientific Meeting on Electrical-Electronics & Biomedical Engineering and Computer Science (EBBT). IEEE, 2019. http://dx.doi.org/10.1109/ebbt.2019.8742077.

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« Antifungal Activities of Chitosan and Nanoparticle Derivatives under Various pH Conditions ». Dans International Conference on Advances in Science, Engineering, Technology and Natural Resources. International Academy of Engineers, 2016. http://dx.doi.org/10.15242/iae.iae1116413.

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Movahedi, Sara, Farshad Bahramian et Fatemeh Ghorbani-Bidkorbeh. « An experimental and numerical study of microfluidic preparation of chitosan nanoparticle ». Dans 2022 29th National and 7th International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2022. http://dx.doi.org/10.1109/icbme57741.2022.10052866.

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Jiang, Dahai, Lingegowda S. Mangala, Hongyu Wang, Sherry Wu, Lokesh G. Rao, Cristian Rodriguez-Aguayo, Sunila Pradeep, David E. Volk, Gabriel Lopez-Berestein et Anil K. Sood. « Abstract 4468 : Tumor vasculature targeting using cell-specific thioaptamer decorated chitosan nanoparticle ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4468.

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Rozana, R., Y. Yulizar, A. Saefumillah et D. O. B. Apriandanu. « Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle ». Dans PROCEEDINGS OF THE 5TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES (ISCPMS2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0007923.

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Wahab, Malik Abdul, et E. Yegan Erdem. « Chitosan Coated Iron-Oxide Nanoparticle Synthesis Using a Droplet Based Microfluidic Reactor ». Dans 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE, 2019. http://dx.doi.org/10.1109/transducers.2019.8808426.

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Rapports d'organisations sur le sujet "Chitosan nanoparticle"

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Yoncheva, Krassimira. Benefits and Perspectives of Nanoparticles Based on Chitosan and Sodium Alginate. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, mars 2020. http://dx.doi.org/10.7546/crabs.2020.03.01.

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Oliveira, Mariana, Vívian Souza, Guilherme Tavares, Rodrigo Fabri et Ana Carolina Apolônio. Effects of antibiotic-loaded chitosan nanoparticles against resistant bacteria : a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, juin 2021. http://dx.doi.org/10.37766/inplasy2021.6.0069.

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