Littérature scientifique sur le sujet « Chemokine-Triggered LFA-1 »
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Articles de revues sur le sujet "Chemokine-Triggered LFA-1"
Feigelson, Sara W., Valentin Grabovsky, Eugenia Manevich-Mendelson, Ronit Pasvolsky, Ziv Shulman, Vera Shinder, Eugenia Klein, Amos Etzioni, Memet Aker et Ronen Alon. « Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1:ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells ». Blood 117, no 26 (30 juin 2011) : 7042–52. http://dx.doi.org/10.1182/blood-2010-12-322859.
Texte intégralWu, Xing, Tao Yu, Daniel C. Bullard et Dennis F. Kucik. « SDF-1α (CXCL12) regulation of lateral mobility contributes to activation of LFA-1 adhesion ». American Journal of Physiology-Cell Physiology 303, no 6 (15 septembre 2012) : C666—C672. http://dx.doi.org/10.1152/ajpcell.00190.2012.
Texte intégralShulman, Ziv, Ronit Pasvolsky, Eilon Woolf, Valentin Grabovsky, Sara W. Feigelson, Noam Erez, Yoshinori Fukui et Ronen Alon. « DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration ». Blood 108, no 7 (1 octobre 2006) : 2150–58. http://dx.doi.org/10.1182/blood-2006-04-017608.
Texte intégralMargraf, Andreas, Giulia Germena, Hannes C. A. Drexler, Jan Rossaint, Nadine Ludwig, Barbara Prystaj, Sina Mersmann et al. « The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1 ». Blood 136, no 19 (5 novembre 2020) : 2200–2205. http://dx.doi.org/10.1182/blood.2020004948.
Texte intégralSáez de Guinoa, Julia, Laura Barrio, Mario Mellado et Yolanda R. Carrasco. « CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics ». Blood 118, no 6 (11 août 2011) : 1560–69. http://dx.doi.org/10.1182/blood-2011-01-332106.
Texte intégralWeber, Kim S. C., Georg Ostermann, Alma Zernecke, Andreas Schröder, Lloyd B. Klickstein et Christian Weber. « Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α : Implications for Leukocyte Transmigration ». Molecular Biology of the Cell 12, no 10 (octobre 2001) : 3074–86. http://dx.doi.org/10.1091/mbc.12.10.3074.
Texte intégralChen, Ying-Yu, Mobeen Malik, Brian E. Tomkowicz, Ronald G. Collman et Andrzej Ptasznik. « BCR-ABL1 Disrupts SDF-1-Dependent Hematopoietic Cell Migration and Adhesion through the LFA-1 Integrin-Mediated Mechanism. » Blood 110, no 11 (16 novembre 2007) : 1011. http://dx.doi.org/10.1182/blood.v110.11.1011.1011.
Texte intégralPasvolsky, Ronit, Sara W. Feigelson, Sara Sebnem Kilic, Amos J. Simon, Guy Tal-Lapidot, Valentin Grabovsky, Jill R. Crittenden et al. « A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets ». Journal of Experimental Medicine 204, no 7 (18 juin 2007) : 1571–82. http://dx.doi.org/10.1084/jem.20070058.
Texte intégralFlaishon, Liat, Gili Hart, Einat Zelman, Christine Moussion, Valentin Grabovsky, Guy Lapidot Tal, Sara Feigelson et al. « Anti-inflammatory effects of an inflammatory chemokine : CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions ». Blood 112, no 13 (15 décembre 2008) : 5016–25. http://dx.doi.org/10.1182/blood-2007-12-129122.
Texte intégralWeber, Kim S. C., Lloyd B. Klickstein et Christian Weber. « Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains ». Molecular Biology of the Cell 10, no 4 (avril 1999) : 861–73. http://dx.doi.org/10.1091/mbc.10.4.861.
Texte intégralThèses sur le sujet "Chemokine-Triggered LFA-1"
TOFFALI, Lara. « Identification of Jak PTK-regulated rho-specific GEFs involved in activation of lymphocyte adhesion ». Doctoral thesis, 2013. http://hdl.handle.net/11562/546549.
Texte intégralThe rapid integrin affinity up-regulation is a crucial dynamic process in leukocyte recruitment that is controlled by a complex inside-out signalling pathway induced by chemokines. Small GTP binding proteins of rap and rho family are certainly the most studied signaling molecules involve in this pathway; in addition our recent data identified Jak PTKs as new upstream regulator of these small GTPases. Considering that Guanosine Exchange Factors (GEFs) are the main direct activators of small GTPases, they represent obvious molecule candidates to fill out the functional gap between Jak PTKs and rho-module. In this study we show the concurrent regulatory role of four rho specific GEFs Vav1, Sos1, Arhgef1 and Dock2 in CXCL12-induced LFA-1 affinity triggering and mediated-adhesion in human T lymphocytes. A reduced expression of these four molecules resulted in an impaired chemokine-induced LFA-1 affinity up-regulation and in a reduced cell adhesion to ICAM-1 in static and under-flow conditions. Importantly, CXCL12-activation of these four proteins is mediated by Jak PTKs and occurs in a time frame coherent with LFA-1 affinity triggering by chemokine. Moreover the activation of RhoA and Rac1 is strictly dependent on Vav1, Sos1, Arhgef1 and Dock2 activity. Collectively in this study we identified and fully characterized the role of four rho-GEFs in CXCL12-induced LFA-1 mediated adhesion providing a comprehensive signalling link between Jak PTKs and rho-module. Considering our results from a quantitative point of view, we observed some variability in the relative regulatory role of these proteins, with a major role for Vav1 and Sos1 with respect to Arhgef1 and Dock2 activity. This variable involvement of multiple rho-GEFs with apparently the same function may support the new emergent quantitative-concurrency view of signal transduction in which this complexity in mechanisms controlling integrin activation is essential to generate a very flexible signalling system able to efficiently respond to a variety of environmental conditions.