Littérature scientifique sur le sujet « Cerebrospinal fluid, amyotrophic lateral sclerosis, microrna »
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Articles de revues sur le sujet "Cerebrospinal fluid, amyotrophic lateral sclerosis, microrna"
Ricci, Claudia, Carlotta Marzocchi et Stefania Battistini. « MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis ». Cells 7, no 11 (20 novembre 2018) : 219. http://dx.doi.org/10.3390/cells7110219.
Texte intégralGentile, Giulia, Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Francesca Luisa Conforti et Sebastiano Cavallaro. « Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases ». Journal of Personalized Medicine 12, no 5 (10 mai 2022) : 770. http://dx.doi.org/10.3390/jpm12050770.
Texte intégralEyileten, Ceren, Lucia Sharif, Zofia Wicik, Daniel Jakubik, Joanna Jarosz-Popek, Aleksandra Soplinska, Marek Postula, Anna Czlonkowska, Agnieszka Kaplon-Cieslicka et Dagmara Mirowska-Guzel. « The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke ». Molecular Neurobiology 58, no 1 (17 septembre 2020) : 329–47. http://dx.doi.org/10.1007/s12035-020-02101-2.
Texte intégralGeekiyanage, Hirosha, Shima Rayatpisheh, James A. Wohlschlegel, Robert Brown et Victor Ambros. « Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides ». Proceedings of the National Academy of Sciences 117, no 39 (14 septembre 2020) : 24213–23. http://dx.doi.org/10.1073/pnas.2008323117.
Texte intégralNakayama, Yui, Satoru Morimoto, Misao Yoneda, Shigeki Kuzuhara et Yasumasa Kokubo. « Cerebrospinal Fluid Biomarkers for Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex ». Journal of Neurodegenerative Diseases 2013 (27 mars 2013) : 1–4. http://dx.doi.org/10.1155/2013/679089.
Texte intégralMatías-Guiu, J., L. Galán, R. García-Ramos, J. A. Barcia et A. Guerrero. « Cerebrospinal fluid cytotoxicity in lateral amyotrophic sclerosis ». Neurología (English Edition) 25, no 6 (2010) : 364–73. http://dx.doi.org/10.1016/s2173-5808(10)70068-7.
Texte intégralFinsterer, Josef, et Bruno Mamoli. « Cerebrospinal fluid filtration in amyotrophic lateral sclerosis ». European Journal of Neurology 6, no 5 (septembre 1999) : 597–600. http://dx.doi.org/10.1046/j.1468-1331.1999.650597.x.
Texte intégralBrettschneider, Johannes, Karin Widl, Dagmar Schattauer, Albert C. Ludolph et Hayrettin Tumani. « Cerebrospinal fluid erythropoietin (EPO) in amyotrophic lateral sclerosis ». Neuroscience Letters 416, no 3 (avril 2007) : 257–60. http://dx.doi.org/10.1016/j.neulet.2007.02.002.
Texte intégralKornhuber, Malte E., et Johannes Kornhuber. « Cerebrospinal fluid amino acids in amyotrophic lateral sclerosis ». Annals of Neurology 31, no 4 (avril 1992) : 449. http://dx.doi.org/10.1002/ana.410310418.
Texte intégralThompson, Alexander G., Elizabeth Gray, Marie-Laëtitia Thézénas, Philip D. Charles, Samuel Evetts, Michele T. Hu, Kevin Talbot, Roman Fischer, Benedikt M. Kessler et Martin R. Turner. « Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis ». Annals of Neurology 83, no 2 (février 2018) : 258–68. http://dx.doi.org/10.1002/ana.25143.
Texte intégralThèses sur le sujet "Cerebrospinal fluid, amyotrophic lateral sclerosis, microrna"
Kostesky, Trisha Ehren. « A study of potential sporadic amyotrophic lateral sclerosis biomarkers in cerebrospinal fluid ». Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35690.
Texte intégralZetterström, Per. « Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis ». Doctoral thesis, Umeå universitet, Klinisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43898.
Texte intégralJonsson, P. Andreas. « Superoxide dismutase 1 and amyotrophic lateral sclerosis ». Doctoral thesis, Umeå : Medical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-611.
Texte intégralGrundström, Eva. « On pathophysiological mechanisms in amyothrophic lateral sclerosis ». Doctoral thesis, Uppsala University, Department of Neuroscience, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521.
Texte intégralAmyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disease with unknown ethiology. The aim of this study was to increase understanding of the pathophysiological mechanisms of dying motor neurons and wasting muscle tissue in this particular disorder.
Quantitative receptor autoradiographic methodology was applied on cervical spinal cord sections from patients with ALS to evaluate the specific binding of the acetylcholine transporter 3H-vesamicol in motor neurons. Despite a significant reduction of the number of ventral motor neurons in ALS, the 3H-vesamicol binding was not reduced in ALS compared to control cases, which suggests an increased metabolic activity in remaining motor neurons.
Motor neurons dying in ALS might go through apoptosis (programmed cell death), so immunohistochemical and TUNEL techniques were applied on thoracic spinal cord from ALS patients to evaluate the possibility of an apoptotic process. The increased Bax expression indicates an apoptotic process and further, motor neurons were TUNEL-positive, indicating DNA degradation caused by programmed cell death.
Muscle biopsies were obtained from ALS patients, and mRNA levels for the neurotrophic factors GDNF and BDNF were measured and compared to control subjects. GDNF levels were increased in muscle tissue in ALS whereas BDNF levels were unaltered.
Levels of GDNF and BDNF were also measured in cerebrospinal fluid from ALS patients and controls using ELISA methodology. Levels of BDNF were unaltered in ALS cornpared to controls. GDNF however was not detectable in controls whereas 12 out of 15 ALS patients had measurab1e levels of GDNW. A marked upregulation of endogenous GDNF and GDNF mRNA in ALS CSF and muscle respectively is of special interest in relation to clinical trials where GDNF is administered to this group of patients.
Johansson, Anders. « Search for biomarkers in ALS and Parkinson's Disease positron emission tomography and cerebrospinal fluid studies / ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univeritetsbiblioteket [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102040.
Texte intégralWuolikainen, Anna. « Metabolomics studies of ALS a multivariate search for clues about a devastating disease / ». Doctoral thesis, Umeå : Department of Pharmacology and Clinical Neuroscience, Umeå university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26894.
Texte intégralRamström, Margareta. « Analysis of Complex Biological Samples using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry ». Doctoral thesis, Uppsala University, Analytical Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5729.
Texte intégralStudies of protein and peptide expression are vital in order to understand complex biological systems. As demonstrated in this thesis, on-line packed capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS) is a useful analytical tool for such studies.
A proteomics method, based on global tryptic digestion and subsequent separation and detection of the peptides by LC-FTICR MS, was developed for qualitative analysis of body fluids. Initial experiments on cerebrospinal fluid (CSF) provided results that were comparable or superior to those achieved by more time- and sample-consuming techniques. The method was also successfully applied on plasma and amniotic fluid. One of the major challenges in proteomics is the broad dynamic range of proteins in biological matrices. The advantages of removing high-abundant components from CSF and plasma prior to MS were demonstrated.
In order to search for potential biomarkers, mass chromatograms of CSF from patients suffering from amyotrophic lateral sclerosis (ALS) and controls were compared using an in-house constructed pattern recognition program. ALS-specific patterns were observed, and four out of five unknown samples were correctly assigned. Alternative strategies to quantitatively compare two pools of samples rely on differential chemical labeling. The performance of one such method, quantification-using-enhanced-signal-tags, was investigated in complex sample analysis. The experimental intensity ratios were proven to be consistent with the prepared concentration ratios of abundant proteins in CSF.
Finally, the thesis reports on the first experiments where electron capture dissociation (ECD) was successfully incorporated in on-line LC-MS experiments. ECD and nozzle-skimmer fragmentation were applied to a sample of endocrine peptides extracted from mouse pancreatic islets. The two fragmentation methods provided complementary information. However, the method needs further optimization before it can be applied in the analysis of more complex samples, such as body fluids.
Lind, Anne-Li. « Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids ». Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-326180.
Texte intégralUppsala Berzelii Technology Centre for Neurodiagnostics
CORRADETTI, RENATO. « Cerebrospinal fluid and serum miRNAs in sporadic amyotrophic lateral sclerosis : potential biomarkers and pathogenic role ». Doctoral thesis, 2016. http://hdl.handle.net/2158/1036322.
Texte intégralFindlater, Joseph. « Peripherin-28 as a Biomarker of ALS : A Methodological Study ». Thesis, 2010. http://hdl.handle.net/1807/25578.
Texte intégralChapitres de livres sur le sujet "Cerebrospinal fluid, amyotrophic lateral sclerosis, microrna"
Silani, V., A. Pizzuti, L. M. Redaelli, R. Bassani, I. R. Causarano, M. Buscaglia, G. Zuliani et G. Scarlato. « ALS Cerebrospinal Fluid Enhances Human Foetal Astroglial Cell Proliferation in Vitro ». Dans Amyotrophic Lateral Sclerosis, 79–81. Boston, MA : Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5302-7_13.
Texte intégralBowser, Robert, James Connor et Martin Turner. « Cerebrospinal fluid-based biomarkers for amyotrophic lateral sclerosis ». Dans Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias, 249–63. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199590674.003.0017.
Texte intégralWormser, Uri, Jessica Mandrioli, Marco Vinceti, Nicola Fini, Amnon Sintov, Berta Brodsky, Elena Proscura et Yoram Finkelstein. « Analysis of Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients : Reduction in Alpha-1-antitrypsin and Increase in IL-23 ». Dans Perspective of Recent Advances in Medical Research Vol. 10, 89–101. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/pramr/v10/4520e.
Texte intégralAhmad Malik, Jonaid, Jeba AjgarAnsari, Sakeel Ahmed, Archana Rani, Shabana Yasmeen Ansari et Sirajudheen Anwar. « Emerging Selenium Nanoparticles for CNS Intervention ». Dans Biomedical Engineering. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109418.
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