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Articles de revues sur le sujet « Cellule vive »

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Auteur : Grafiati
Publié le 11 mars 2023

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1

Farhat, Raed, Ayman El-Seedy, Kamal El-Moussaoui, Marie-Claude Pasquet, Catherine Adolphe, Eric Bieth, Jeanne Languepin, Isabelle Sermet-Gaudelus, Alain Kitzis et Véronique Ladevèze. « Multi-physiopathological consequences of the c.1392G>T CFTR mutation revealed by clinical and cellular investigations ». Biochemistry and Cell Biology 93, no 1 (février 2015) : 28–37. http://dx.doi.org/10.1139/bcb-2014-0042.

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This study combines a clinical approach and multiple level cellular analyses to determine the physiopathological consequences of the c.1392G>T (p.Lys464Asn) CFTR exon 10 mutation, detected in a CF patient with a frameshift deletion in trans and a TG(11)T(5) in cis. Minigene experiment, with different TG(m)T(n) alleles, and nasal cell mRNA extracts were used to study the impact of c.1392G>T on splicing in both in cellulo and in vivo studies. The processing and localization of p.Lys464Asn protein were evaluated, in cellulo, by western blotting analyses and confocal microscopy. Clinical and channel exploration tests were performed on the patient to determine the exact CF phenotype profile and the CFTR chloride transport activity. c.1392G>T affects exon 10 splicing by inducing its complete deletion and encoding a frameshift transcript. The polymorphism TG(11)T(5) aggravates the effects of this mutation on aberrant splicing. Analysis of mRNA obtained from parental airway epithelial cells confirmed these in cellulo results. At the protein level the p.Lys464Asn protein showed neither maturated form nor membrane localization. Furthermore, the in vivo channel tests confirmed the absence of CFTR activity. Thus, the c.1392G>T mutation alone or in association with the TG repeats and the poly T tract revealed obvious impacts on splicing and CFTR protein processing and functionality. The c.[T(5); 1392G>T] complex allele contributes to the CF phenotype by affecting splicing and inducing a severe misprocessing defect. These results demonstrate that the classical CFTR mutations classification is not sufficient: in vivo and in cellulo studies of a possible complex allele in a patient are required to provide correct CFTR mutation classification, adequate medical counseling, and adapted therapeutic strategies.
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Sheng, Guojun. « Vive la difference ». Cell Adhesion & ; Migration 4, no 3 (juillet 2010) : 439. http://dx.doi.org/10.4161/cam.4.3.12642.

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Wong, RaymondChing-Bong, et Tu Nguyen. « Neuroregeneration using in vivo cellular reprogramming ». Neural Regeneration Research 12, no 7 (2017) : 1073. http://dx.doi.org/10.4103/1673-5374.211182.

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Peng, Tao, et Howard C. Hang. « SORTing out cellular proteomes in vivo ». Nature Biotechnology 32, no 5 (mai 2014) : 445–46. http://dx.doi.org/10.1038/nbt.2898.

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Trani, Jose L., Howard K. Song, Susan M. Lerner, Hooman Noorchashm, Joseph W. Markmann, Jing Wang, Clyde F. Barker, Ali Naji et James F. Markmann. « IN VIVO CHARACTERIZATION OF CELLULAR XENOIMMUNITY ». Transplantation 67, no 9 (mai 1999) : S554. http://dx.doi.org/10.1097/00007890-199905150-00072.

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Modo, Michel, Mathias Hoehn et Jeff W. M. Bulte. « Cellular MR Imaging ». Molecular Imaging 4, no 3 (1 juillet 2005) : 153535002005051. http://dx.doi.org/10.1162/15353500200505145.

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Cellular MR imaging is a young field that aims to visualize targeted cells in living organisms. In order to provide a different signal intensity of the targeted cell, they are either labeled with MR contrast agents in vivo or prelabeled in vitro. Either (ultrasmall) superparamagnetic iron oxide [(U)SPIO] particles or (polymeric) paramagnetic chelates can be used for this purpose. For in vivo cellular labeling, Gd3+- and Mn2+- chelates have mainly been used for targeted hepatobiliary imaging, and (U)SPIO-based cellular imaging has been focused on imaging of macrophage activity. Several of these magneto-pharmaceuticals have been FDA-approved or are in late-phase clinical trials. As for prelabeling of cells in vitro, a challenge has been to induce a sufficient uptake of contrast agents into nonphagocytic cells, without affecting normal cellular function. It appears that this issue has now largely been resolved, leading to an active research on monitoring the cellular biodistribution in vivo following transplantation or transfusion of these cells, including cell migration and trafficking. New applications of cellular MR imaging will be directed, for instance, towards our understanding of hematopoietic (immune) cell trafficking and of novel guided (stem) cell-based therapies aimed to be translated to the clinic in the future.
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Boppart, Stephan A., Brett E. Bouma, Costas Pitris, James F. Southern, Mark E. Brezinski et James G. Fujimoto. « In vivo cellular optical coherence tomography imaging ». Nature Medicine 4, no 7 (juillet 1998) : 861–65. http://dx.doi.org/10.1038/nm0798-861.

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Rice, Andrew P., et Jason T. Kimata. « Cellular cofactors and HIV-1 infectionin vivo ». Future Virology 1, no 3 (mai 2006) : 337–47. http://dx.doi.org/10.2217/17460794.1.3.337.

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Hornsby, P. J. « Cellular Senescence and Tissue Aging In Vivo ». Journals of Gerontology Series A : Biological Sciences and Medical Sciences 57, no 7 (1 juillet 2002) : B251—B256. http://dx.doi.org/10.1093/gerona/57.7.b251.

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Tréton, J. A. « Cellular aging, in vitro and in vivo ». Aging Clinical and Experimental Research 5, no 4 (août 1993) : 291–97. http://dx.doi.org/10.1007/bf03324177.

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Srivastava, Deepak, et Natalie DeWitt. « In Vivo Cellular Reprogramming : The Next Generation ». Cell 166, no 6 (septembre 2016) : 1386–96. http://dx.doi.org/10.1016/j.cell.2016.08.055.

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Frederick, Jane, Ranya Virk, Greta Wodarcyk, Luay M. Almassalha, David VanDerway, Vasundhara Agrawal, John Carinato, Igal Szleifer et Vadim Backman. « Targeting chromatin mediated cellular plasticity in vivo ». Biophysical Journal 122, no 3 (février 2023) : 491a. http://dx.doi.org/10.1016/j.bpj.2022.11.2626.

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Masrina, Angel Bintang, Muhammad Amin et Pristiyanilicia Putri. « Implementasi E-CRM Untuk Meningkatkan Penjualan Produk Di Toko Matrix Celluler Berbasis Web ». JUTSI (Jurnal Teknologi dan Sistem Informasi) 2, no 2 (28 juin 2022) : 77–84. http://dx.doi.org/10.33330/jutsi.v2i2.1683.

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Abstract : Matrix Celluler who is on the road Prof. H.M. Yamin No.16, Kisaran Naga, Kec. Kisaran Eastern, Asahan Regency, North Sumatera namely store that process transactions in cash and credit with sales products namely Handphone Samsung, Vivo, Oppo, dan Nokia. Besides Handphone, Matrix Celluler also provide Accessories in the form of Charger, Antigores, Handsfree, and Softcase. This research was conducted with the aim of designing a new system, namely Customer Relationship Management that is attractive and effective for sales and customer service according to the needs of the store and customers, Helping Cellular Matrix give trust to customers by implementing cash, credit and COD (Cash) transaction features. On Delivery) in the system and provide solutions to increase sales revenue at Matrix Celluler stores such as implementing coin and voucher features to customers. The research method use qualitative methods with a qualitative descriptive design format with data collection techniques, namely interview, observation and library research. This system is designed using several software namely Sublime Text 3, XAMPP, PHP, dan MySQL. Keywords : Increase Sales; CRM, Design; and Website. Abstrak : Matrix Celluler yang berada di jalan Prof. H.M. Yamin No.16, Kisaran Naga, Kec. Kisaran Timur, Kabupaten Asahan, Sumatera Utara yakni sebuah toko yang melakukan proses transaksi secara cash dan kredit dengan produk penjualan yaitu Handphone Samsung, Vivo, Oppo, dan Nokia. Selain Handphone, Matrix Celluler juga menyediakan Accessories berupa Charger, Antigores, Handsfree, dan Softcase. Penelitian ini dilakukan dengan tujuan untuk merancang suatu sistem yang baru yaitu Customer Relationship Management yang menarik dan efektif untuk penjualan dan pelayanan pelanggan sesuai dengan kebutuhan pihak toko dan pelanggan, Membantu Matrix Celluler memberikan kepercayaan kepada pelanggan dengan menerapkan fitur transaksi cash, kredit dan COD (Cash On Delivery) di sistem dan memberikan solusi dalam meningkatkan hasil pendapatan penjualan di toko Matrix Celluler seperti menerapkan fitur koin dan voucher kepada pelanggan. Metode penelitian menggunakan metode kualitatif dengan format desain deskriptif kualitatif dengan teknik pengumpulan data yaitu wawancara, observasi dan penelitian kepustakaan. Sistem ini di rancang dengan menggunakan beberapa software yaitu Sublime Text 3, XAMPP, PHP, dan MySQL. Kata Kunci : Meningkatkan Penjualan; CRM; Perancangan; Website.
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Genet, F. « Para-ostéoarthropathies neurogènes : de la cellule au patient et vice et versa ». Annals of Physical and Rehabilitation Medicine 55 (octobre 2012) : e172. http://dx.doi.org/10.1016/j.rehab.2012.07.440.

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Arizono, Misa, et U. Valentin Nägerl. « Plus vive, plus nette : la microscopie STED du cerveau ». Photoniques, no 114 (2022) : 36–39. http://dx.doi.org/10.1051/photon/202111436.

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La microscopie à super-résolution (SRM) désigne une nouvelle catégorie de techniques de microscopie optique qui permettent de surmonter la barrière de diffraction classique,- barrière qui a rendu difficile l’observation des structures et des activités qui constituent la base de la vie cellulaire biologique. La microscopie STED, qui est l'une des techniques SRM, a attiré l'attention des neurobiologistes, car elle permet de révéler la nanostructure des cellules cérébrales non seulement dans une boîte de Pétri, mais aussi à l'intérieur du tissu cérébral réel, voire dans le cerveau intact in vivo.
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Schatten, Gerald. « Cellular promiscuity : explaining cellular fidelity in vivo against unrestrained pluripotency in vitro ». EMBO reports 14, no 1 (11 décembre 2012) : 4. http://dx.doi.org/10.1038/embor.2012.198.

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Schatten, Gerald. « Cellular promiscuity : explaining cellular fidelity in vivo against unrestrained pluripotency in vitro ». EMBO reports 14, no 2 (21 décembre 2012) : 212. http://dx.doi.org/10.1038/embor.2012.216.

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Obert, Laurent, Florelle Gindraux, Karim Oudina, Hervé Petite, Alain Meunier, Patrick Garbuio, Patrick Hervé et Frédéric Deschaseaux. « 83 Utilisation des cellules souches ostéorégénératrices : étude in vivo préliminaire ». Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Moteur 90, no 6 (octobre 2004) : 70–71. http://dx.doi.org/10.1016/s0035-1040(04)70550-4.

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Ivanovic, Z., et J. M. Boiron. « Expansion ex vivo des cellules hematopoiétiques : concept et utilité clinique ». Transfusion Clinique et Biologique 16, no 5-6 (novembre 2009) : 489–500. http://dx.doi.org/10.1016/j.tracli.2009.10.002.

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Grigoryeva, N. A., M. S. Zhukov et Yu Yu Vladimirova. « EFFECT OF THE DRUG GENTABIFERON-S ON THE STATE OF CELLULAR IMMUNITY IN THE EXPERIMENT IN VIVO ». BULLETIN OF VETERINARY PHARMACOLOGY 4, no 17 (2021) : 8–18. http://dx.doi.org/10.17238/issn2541-8203.2021.4.8.

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Antonyan, I. М., O. A. Omelchenko et A. S. Zabirnik. « Animal Hormonal Status Changes in Androgen Deficiency (AD) Settings under Influence of Stem Cells Syngeneic Culture. Cellular Tracking and Fluorescence Imaging ex vivo/in vivo ». Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 2, no 2 (24 mai 2017) : 7–15. http://dx.doi.org/10.26693/jmbs02.02.007.

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Dasnur Nanjappa, Madhusudan, Anup Pandith, Svetlana Sankaran, Dorothy Priyanka Dorairaj, Anusha Anjaneya Reddy et Hari Prasad Badubanahalli Ramesh. « Recent Advancements in Developments of Novel Fluorescent Probes : In Cellulo Recognitions of Alkaline Phosphatases ». Symmetry 14, no 8 (9 août 2022) : 1634. http://dx.doi.org/10.3390/sym14081634.

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Alkaline phosphatase (ALP) is one of the vital phospho-ester bond cleaving biocatalysts that has inevitable significance in cellular systems, viz., early-stage osteoblast differentiation, cell integrity in tissues, bone mineralization, cancer biomarker, liver dysfunction, cellular osmotic pressure, protein folding and many more. Variation from optimal levels of ALP in intra and extracellular fluids can cause severe diseases, including death. Due to these reasons, ALP is considered as a vital biomarker for various preclinical and medical diagnosis. Fluorescence image-based diagnosis is the most widely used method, owing to its simplicity, robustness, non-invasive properties and excellent spatio-temporal resolution (up to the nM/pM level), as compared to conventional analytical techniques, such as the electroanalytical method, nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC). Most of the reviews reported for ALP’s recognition in the literature scarcely explain the structurally related, photophysical and biophysical parameters; and the sub-cellular localizations. Considering these facts, in order to enhance the opto-analytical parameters of fluorescence-based diagnostic materials at the cellular level, herein we have systematically documented recent developments in the opto-analytical capabilities of quencher-free probes for ALP, used in in vitro (biological buffers) to in cellulo conditions, along with in vivo models.
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Prieto, Luis I., Sara I. Graves et Darren J. Baker. « Insights from In Vivo Studies of Cellular Senescence ». Cells 9, no 4 (13 avril 2020) : 954. http://dx.doi.org/10.3390/cells9040954.

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Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells remain metabolically active and often acquire a distinctive bioactive secretory phenotype. Much of our molecular understanding in senescent cell biology comes from studies using mammalian cell lines exposed to stress or extended culture periods. While less well understood mechanistically, senescence in vivo is becoming appreciated for its numerous biological implications, both in the context of beneficial processes, such as development, tumor suppression, and wound healing, and in detrimental conditions, where senescent cell accumulation has been shown to contribute to aging and age-related diseases. Importantly, clearance of senescent cells, through either genetic or pharmacological means, has been shown to not only extend the healthspan of prematurely and naturally aged mice but also attenuate pathology in mouse models of chronic disease. These observations have prompted an investigation of how and why senescent cells accumulate with aging and have renewed exploration into the characteristics of cellular senescence in vivo. Here, we highlight our molecular understanding of the dynamics that lead to a cellular arrest and how various effectors may explain the consequences of senescence in tissues. Lastly, we discuss how exploitation of strategies to eliminate senescent cells or their effects may have clinical utility.
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Girard, Nadine J., et Charles A. Raybaud. « In Vivo MRI of Fetal Brain Cellular Migration ». Journal of Computer Assisted Tomography 16, no 2 (mars 1992) : 265–67. http://dx.doi.org/10.1097/00004728-199203000-00016.

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Brown, David R., Kefeng Qin, Jochen W. Herms, Axel Madlung, Jean Manson, Robert Strome, Paul E. Fraser et al. « The cellular prion protein binds copper in vivo ». Nature 390, no 6661 (décembre 1997) : 684–87. http://dx.doi.org/10.1038/37783.

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Nourshargh, Sussan, et Timothy J. Williams. « Molecular and cellular interactions mediating granulocyteaccumulation in vivo ». Seminars in Cell Biology 6, no 6 (décembre 1995) : 317–26. http://dx.doi.org/10.1016/s1043-4682(05)80002-9.

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Rank, Andreas, Rienk Nieuwland, Ruth Delker, Anton Köhler, Bettina Toth, Verena Pihusch, Ralf Wilkowski et Rudolf Pihusch. « Cellular origin of platelet-derived microparticles in vivo ». Thrombosis Research 126, no 4 (octobre 2010) : e255-e259. http://dx.doi.org/10.1016/j.thromres.2010.07.012.

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Prieur, Alexandre, et Daniel S. Peeper. « Cellular senescence in vivo : a barrier to tumorigenesis ». Current Opinion in Cell Biology 20, no 2 (avril 2008) : 150–55. http://dx.doi.org/10.1016/j.ceb.2008.01.007.

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Arbab, Ali, Branislava Janic, Jodi Haller, Edyta Pawelczyk, Wei Liu et Joseph Frank. « In Vivo Cellular Imaging for Translational Medical Research ». Current Medical Imaging Reviews 5, no 1 (1 février 2009) : 19–38. http://dx.doi.org/10.2174/157340509787354697.

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Berry, Ryan, et Matthew S. Rodeheffer. « Characterization of the adipocyte cellular lineage in vivo ». Nature Cell Biology 15, no 3 (24 février 2013) : 302–8. http://dx.doi.org/10.1038/ncb2696.

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Aigner, A. « Cellular Delivery In Vivo of siRNA-Based Therapeutics ». Current Pharmaceutical Design 14, no 34 (1 décembre 2008) : 3603–19. http://dx.doi.org/10.2174/138161208786898815.

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Bryans, Margaret, Erin Harley et Susan K. Gilmour. « Elevated Cellular Polyamine Levels Enhance Promoter Activityin Vivo ». Biochemical and Biophysical Research Communications 226, no 3 (septembre 1996) : 618–25. http://dx.doi.org/10.1006/bbrc.1996.1405.

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Behle, Eric, Julian M. Herold et Alexander H. Schug. « Towards cellular digital twins of in vivo tumors ». Biophysical Journal 122, no 3 (février 2023) : 301a—302a. http://dx.doi.org/10.1016/j.bpj.2022.11.1700.

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Brovko, Lubov Y., et Mansel W. Griffiths. « Illuminating Cellular Physiology : Recent Developments ». Science Progress 90, no 2-3 (juillet 2007) : 129–60. http://dx.doi.org/10.3184/003685007x215986.

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Bioluminescent methods are gaining more and more attention among scientists due to their sensitivity, selectivity and simplicity; coupled with the fact that the bioluminescence can be monitored both in vitro and in vivo. Since the discovery of bioluminescence in the 19th century, enzymes involved in the bioluminescent process have been isolated and cloned. The bioluminescent reactions in several different organisms have also been fully characterized and used as reporters in a wide variety of biochemical assays. From the 1990s it became clear that bioluminescence can be detected and quantified directly from inside a living cell. This gave rise to numerous possibilities for the in vivo monitoring of intracellular processes non-invasively using bioluminescent molecules as reporters. This review describes recent developments in the area of bioluminescent imaging for cell biology. Newly developed imaging methods allow transcriptional/translational regulation, signal transduction, protein–protein interaction, oncogenic transformation, cell and protein trafficking, and target drug action to be monitored in vivo in real-time with high temporal and spatial resolution; thus providing researchers with priceless information on cellular functions. Advantages and limitations of these novel bioluminescent methods are discussed and possible future developments identified.
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Ivanovic, Z., P. Duchez, J. Chevaleyre, M. Vlaski, P. Brunet de la Grange et G. Wouters. « Cryoconservation de cellules souches et progénitrices hématopoïétiques amplifiées ex vivo à partir de cellules CD34+ de sang placentaire ». Transfusion Clinique et Biologique 20, no 3 (juin 2013) : 343. http://dx.doi.org/10.1016/j.tracli.2013.03.183.

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Norol, F., M. Drouet, N. Debili, W. Vainchenker et F. Herodin. « Expansion ex-vivo des cellules hématopoïétiques : étude dans le modèle primate ». Hematology and Cell Therapy 41, no 2 (avril 1999) : 75–77. http://dx.doi.org/10.1007/s00282-999-0075-x.

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Warrick, Emilie, Valérie Bergoglio, Françoise Bernerd et Thierry Magnaldo. « Cellules souches épidermiques et thérapie génique cutanéeex vivo : application auxeroderma pigmentosum ». Journal de la Société de Biologie 202, no 1 (2008) : 33–41. http://dx.doi.org/10.1051/jbio:2008005.

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Athanasopoulou, Sophia, Marianna Kapetanou, Michel Georges Magouritsas, Nikoletta Mougkolia, Polykseni Taouxidou, Michael Papacharalambous, Fotios Sakellaridis et Efstathios Gonos. « Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex : Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial ». Antioxidants 11, no 3 (26 février 2022) : 468. http://dx.doi.org/10.3390/antiox11030468.

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Aging is a dynamic procedure that is developed in multiple layers and characterized by distinct hallmarks. The use of biomarkers that target different hallmarks of aging is substantial in predicting adverse outcomes during the aging process, implementing specifically designed antiaging interventions and monitoring responses to these interventions. The present study aimed to develop a novel composition of plant extracts, comprising identified active ingredients that synergistically target different hallmarks of aging in cellulo and in vivo. The selected single extracts and the developed composition were tested through a powerful set of biomarkers that we have previously identified and studied. The composition of selected extracts simultaneously increased cellular lifespan, reduced the cellular oxidative load and enhanced antioxidant defense mechanisms by increasing proteasome activity and content. In addition, the combination prevented telomere attrition and preserved optimum DNA methylation levels. Remarkably, biomarker profiling of healthy volunteers who received the identified combination in the form of a nutritional supplement within the frame of a prospective, randomized, controlled 3-month trial revealed an unprecedented antioxidant capacity in humans. In conclusion, our results support the notion that interventions with specifically designed combinations of natural compounds targeting multiple hallmarks of aging represent an effective way to improve healthspan and well-being.
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Li, Joanne, Madison N. Wilson, Andrew J. Bower, Marina Marjanovic, Eric J. Chaney, Ronit Barkalifa et Stephen A. Boppart. « Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin ». Journal of Innovative Optical Health Sciences 13, no 02 (15 janvier 2020) : 2050007. http://dx.doi.org/10.1142/s1793545820500078.

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To date, numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases, but few have attempted to characterize these cellular events under conditions similar to the native environment. To address this challenge, a three-dimensional (3D) multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin, which was then utilized to process in vivo wound healing data to demonstrate its applicability. Special attention is focused on in vivo biological parameters that are difficult to study with ex vivo analysis, including 3D cell tracking and techniques to connect biological information obtained from different imaging modalities. These results here open new possibilities for evaluating 3D cellular dynamics in vivo, and can potentially provide new tools for characterizing the skin microenvironment and pathologies in the future.
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Di Lullo, A. M., M. Scorza, F. Amato, M. Comegna, V. Raia, L. Maiuri, G. Ilardi, E. Cantone, G. Castaldo et M. Iengo. « An “ex vivo model” contributing to the diagnosis and evaluation of new drugs in cystic fibrosis ». Acta Otorhinolaryngologica Italica 37, no 3 (juin 2017) : 207–13. http://dx.doi.org/10.14639/0392-100x-1328.

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La fibrosi cistica (FC) è una malattia autosomica recessiva causata da mutazioni nel gene CFTR (Cystic Fibrosis Transmembrane conductance Regulator). Finora sono state descritte circa 2000 mutazioni, ma per la maggior parte di esse è difficile definirne l’effetto senza complesse procedure in vitro. Abbiamo effettuato il campionamento (mediante brushing), la cultura e l’analisi di cellule epiteliali nasali umane (HNEC) utilizzando una serie di tecniche che possono aiutare a testare l’effetto delle mutazioni CFTR. Abbiamo eseguito 50 brushing da pazienti FC e controlli, e in 45 casi si è ottenuta una coltura positiva. Utilizzando cellule in coltura: i) abbiamo dimostrato l’espressione ampiamente eterogenea del CFTR nei pazienti e nei controlli; ii) abbiamo definito l’effetto di splicing di una mutazione sul gene CFTR; iii) abbiamo valutato l’attività di gating di CFTR in pazienti portatori di differenti mutazioni; iv) abbiamo dimostrato che il butirrato migliora in modo significativo l’espressione di CFTR. I dati provenienti dal nostro studio sperimentale dimostrano che l’uso del modello ex-vivo di cellule epiteliali nasali è un importante e valido strumento di ricerca e di diagnosi nella studio della FC e può anche essere mirato alla sperimentazione ed alla verifica di nuovi farmaci. In definitiva, in base ai nostri dati è possibile esprimere le seguenti conclusioni: 1) il prelievo delle cellule epiteliali nasali mediante brushing è applicabile senza alcuna anestesia ed è ben tollerato da tutti i pazienti affetti da FC (bambini e adulti), è scarsamente invasivo e facilmente ripetibile, è anche in grado di ottenere una sufficiente quantità di HNECs rappresentative, ben conservate, idonee allo studio della funzionalità di CFTR; 2) la conservazione delle cellule prelevate è possibile fino a 48 ore prima che si provveda all’allestimento della coltura e ciò permette di avviare studi multicentrici con prelievi in ogni sede e quindi di ottenere una ampia numerosità campionaria; 3) la coltura di cellule epiteliali nasali può essere considerata un modello adatto a studiare l’effetto molecolare di nuove mutazioni del gene CFTR e/o mutazioni specifiche di pazienti “carriers” dal significato incerto; 4) il modello ex-vivo delle HNECs consente inoltre di valutare, prima dell’impiego nell’uomo, l’effetto di farmaci (potenziatori e/o correttori) sulle cellule di pazienti portatori di mutazioni specifiche di CFTR; tali farmaci possono modulare l’espressione genica del canale CFTR aprendo così nuove frontiere terapeutiche e migliori prospettive di vita per pazienti affetti da una patologia cronica come la Fibrosi Cistica; 5) la metodologia da noi istituita risulta essere idonea alla misura quantitativa, mediante fluorescenza, dell’attività di gating del canale CFTR presente nelle membrane delle cellule epiteliali nasali prelevate da pazienti portatori di differenti genotipi; in tal modo è possibile individuare: a) pazienti FC portatori di 2 mutazioni gravi con un’attività < 10% (in rapporto ai controlli -100%), b) soggetti FC portatori contemporaneamente di una mutazione grave e di una lieve con un’attività tra 10-30%, c) i cosiddetti portatori “carriers”- eterozigoti - con un’attività tra 40-70%. In conclusione la possibilità di misurare l’attività del canale CFTR in HNECs fornisce un importante contributo alla diagnosi di FC, mediante individuazione di un “cut-off diagnostico”, ed anche alla previsione della gravità fenotipica della malattia; quindi quanto rilevabile dalla misura del suddetto canale permette di prospettare per il futuro la possibilità di valutare meglio i pazienti per i quali il test del sudore ha dato risultati ambigui (borderline o negativi). La metodica da noi sperimentata consente anche di monitorare i pazienti durante il trattamento farmacologico, valutando in tal modo i reali effetti delle nuove terapie.
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41

Duchez, Pascale, Laura Rodriguez, Philippe Brunet De La Grange et Zoran Ivanovic. « Cryoconservation de cellules souches et de progéniteurs hématopoïétiques amplifiés ex vivo à partir de cellules CD34+ de sang placentaire ». Transfusion Clinique et Biologique 24, no 3 (septembre 2017) : 377. http://dx.doi.org/10.1016/j.tracli.2017.06.300.

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Ito, Kenji, et Yasuhiro Yamada. « Cellular reprogramming technology for dissecting cancer epigenome in vivo ». Epigenomics 9, no 7 (juillet 2017) : 997–1011. http://dx.doi.org/10.2217/epi-2017-0018.

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Radbruch, Helena, Daniel Bremer, Ronja Mothes, Robert Günther, Jan Rinnenthal, Julian Pohlan, Carolin Ulbricht, Anja Hauser et Raluca Niesner. « Intravital FRET : Probing Cellular and Tissue Function in Vivo ». International Journal of Molecular Sciences 16, no 12 (21 mai 2015) : 11713–27. http://dx.doi.org/10.3390/ijms160511713.

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Keating, John H., R. Alan Wilson et Patrick J. Skelly. « No Overt Cellular Inflammation Around Intravascular Schistosomes In Vivo ». Journal of Parasitology 92, no 6 (décembre 2006) : 1365–69. http://dx.doi.org/10.1645/ge-864r.1.

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Cooper, Curtis, L. « Antiretroviral therapy influences cellular susceptibility to apoptosis in vivo ». Frontiers in Bioscience 9, no 1-3 (2004) : 338. http://dx.doi.org/10.2741/1230.

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Hamza, T., M. Dietz, D. Pham, N. Clovis, S. Danley et B. Li. « Intra-cellular Staphylococcus aureus alone causes infection in vivo ». European Cells and Materials 25 (8 juillet 2013) : 341–50. http://dx.doi.org/10.22203/ecm.v025a24.

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Joshi, Radhika S., et Mitradas M. Panicker. « Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs ». eneuro 5, no 5 (septembre 2018) : ENEURO.0220–18.2018. http://dx.doi.org/10.1523/eneuro.0220-18.2018.

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Bass, K. D., A. Byrne, C. Ulrich et L. Mockros. « OPTIMIZATION OF CELLULAR FUNCTION DURING EX-VIVO EXTRACORPOREAL CIRCULATION ». ASAIO Journal 43, no 2 (mars 1997) : 35. http://dx.doi.org/10.1097/00002480-199703000-00127.

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Delikatny, Edward J., et Harish Poptani. « MR techniques for in vivo molecular and cellular imaging ». Radiologic Clinics of North America 43, no 1 (janvier 2005) : 205–20. http://dx.doi.org/10.1016/j.rcl.2004.07.004.

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Boretius, Susann, Lars Kasper, Roland Tammer, Thomas Michaelis et Jens Frahm. « MRI of cellular layers in mouse brain in vivo ». NeuroImage 47, no 4 (octobre 2009) : 1252–60. http://dx.doi.org/10.1016/j.neuroimage.2009.05.095.

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