Bibliographies thématiques / Cellular Targeting, Imaging and Therapy

Littérature scientifique sur le sujet « Cellular Targeting, Imaging and Therapy »

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Publié le 7 septembre 2023

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Articles de revues sur le sujet "Cellular Targeting, Imaging and Therapy"

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Guan, Jiankun, Yuxin Wu, Huimin Wang, Haowen Zeng, Zifu Li et Xiangliang Yang. « A DiR loaded tumor targeting theranostic cisplatin-icodextrin prodrug nanoparticle for imaging guided chemo-photothermal cancer therapy ». Nanoscale 13, no 46 (2021) : 19399–411. http://dx.doi.org/10.1039/d1nr05824j.

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A novel theranostic nanoplatform DPtFIP exhibited outstanding tumor targeting ability, imaging and photothermal properties, increased cellular uptake, selective drug release, and potent antitumor effect with decreased toxicity.
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Serda, Rita E., Natalie L. Adolphi, Marco Bisoffi et Laurel O. Sillerud. « Targeting and Cellular Trafficking of Magnetic Nanoparticles for Prostate Cancer Imaging ». Molecular Imaging 6, no 4 (1 juillet 2007) : 7290.2007.00025. http://dx.doi.org/10.2310/7290.2007.00025.

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Antibody-conjugated iron oxide nanoparticles offer a specific and sensitive tool to enhance magnetic resonance (MR) images of both local and metastatic cancer. Prostate-specific membrane antigen (PSMA) is predominantly expressed on the neovasculature of solid tumors and on the surface of prostate cells, with enhanced expression following androgen deprivation therapy. Biotinylated anti-PSMA antibody was conjugated to streptavidin-labeled iron oxide nanoparticles and used in MR imaging and confocal laser scanning microscopic imaging studies using LNCaP prostate cancer cells. Labeled iron oxide nanoparticles are internalized by receptor-mediated endocytosis, which involves the formation of clathrin-coated vesicles. Endocytosed particles are not targeted to the Golgi apparatus for recycling but instead accumulate within lysosomes. In T1-weighted MR images, the signal enhancement owing to the magnetic particles was greater for cells with magnetic particles bound to the cell surface than for cells that internalized the particles. However, the location of the particles (surface vs internal) did not significantly alter their effect on T2-weighted images. Our findings indicate that targeting prostate cancer cells using PSMA offers a specific and sensitive technique for enhancing MR images.
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Jiang, Shan, Muthu Kumara Gnanasammandhan et Yong Zhang. « Optical imaging-guided cancer therapy with fluorescent nanoparticles ». Journal of The Royal Society Interface 7, no 42 (16 septembre 2009) : 3–18. http://dx.doi.org/10.1098/rsif.2009.0243.

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The diagnosis and treatment of cancer have been greatly improved with the recent developments in nanotechnology. One of the promising nanoscale tools for cancer diagnosis is fluorescent nanoparticles (NPs), such as organic dye-doped NPs, quantum dots and upconversion NPs that enable highly sensitive optical imaging of cancer at cellular and animal level. Furthermore, the emerging development of novel multi-functional NPs, which can be conjugated with several functional molecules simultaneously including targeting moieties, therapeutic agents and imaging probes, provides new potentials for clinical therapies and diagnostics and undoubtedly will play a critical role in cancer therapy. In this article, we review the types and characteristics of fluorescent NPs, in vitro and in vivo imaging of cancer using fluorescent NPs and multi-functional NPs for imaging-guided cancer therapy.
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Santoso, Michelle R., et Phillip C. Yang. « Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial Infarction ». Stem Cells International 2016 (2016) : 1–9. http://dx.doi.org/10.1155/2016/4198790.

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Stem cell therapy has broad applications in regenerative medicine and increasingly within cardiovascular disease. Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. Injuries to the heart are often permanent due to the limited proliferation and self-healing capability of cardiomyocytes; as such, stem cell therapy has become increasingly important in the treatment of cardiovascular diseases. Despite extensive efforts to optimize cardiac stem cell therapy, challenges remain in the delivery and monitoring of cells injected into the myocardium. Other fields have successively used nanoscience and nanotechnology for a multitude of biomedical applications, including drug delivery, targeted imaging, hyperthermia, and tissue repair. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed for molecular and cellular imaging. In this mini-review, we focus on the application of superparamagnetic iron oxide nanoparticles in targeting and monitoring of stem cells for the treatment of myocardial infarctions.
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Chen, Bin, Brian W. Pogue, P. Jack Hoopes et Tayyaba Hasan. « Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy ». International Journal of Radiation Oncology*Biology*Physics 61, no 4 (mars 2005) : 1216–26. http://dx.doi.org/10.1016/j.ijrobp.2004.08.006.

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Jin, Zhao-Hui, Atsushi B. Tsuji, Mélissa Degardin, Pascal Dumy, Didier Boturyn et Tatsuya Higashi. « Multiplexed Imaging Reveals the Spatial Relationship of the Extracellular Acidity-Targeting pHLIP with Necrosis, Hypoxia, and the Integrin-Targeting cRGD Peptide ». Cells 11, no 21 (4 novembre 2022) : 3499. http://dx.doi.org/10.3390/cells11213499.

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pH (low) insertion peptides (pHLIPs) have been developed for cancer imaging and therapy targeting the acidic extracellular microenvironment. However, the characteristics of intratumoral distribution (ITD) of pHLIPs are not yet fully understood. This study aimed to reveal the details of the ITD of pHLIPs and their spatial relationship with other tumor features of concern. The fluorescent dye-labeled pHLIPs were intravenously administered to subcutaneous xenograft mouse models of U87MG and IGR-OV1 expressing αVβ3 integrins (using large necrotic tumors). The αVβ3 integrin-targeting Cy5.5-RAFT-c(-RGDfK-)4 was used as a reference. In vivo and ex vivo fluorescence imaging, whole-tumor section imaging, fluorescence microscopy, and multiplexed fluorescence colocalization analysis were performed. The ITD of fluorescent dye-labeled pHLIPs was heterogeneous, having a high degree of colocalization with necrosis. A direct one-to-one comparison of highly magnified images revealed the cellular localization of pHLIP in pyknotic, karyorrhexis, and karyolytic necrotic cells. pHLIP and hypoxia were spatially contiguous but not overlapping cellularly. The hypoxic region was found between the ITDs of pHLIP and the cRGD peptide and the Ki-67 proliferative activity remained detectable in the pHLIP-accumulated regions. The results provide a better understanding of the characteristics of ITD of pHLIPs, leading to new insights into the theranostic applications of pHLIPs.
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Liang, Zhiquan, Ziwen Lu, Yafei Zhang, Dongsheng Shang, Ruyan Li, Lanlan Liu, Zhicong Zhao et al. « Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy ». Current Cancer Drug Targets 19, no 6 (21 juin 2019) : 449–67. http://dx.doi.org/10.2174/1568009618666181010091246.

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Ovarian cancer is a leading cause of death worldwide from gynecological malignancies, mainly because there are few early symptoms and the disease is generally diagnosed at an advanced stage. In addition, despite the effectiveness of cytoreductive surgery for ovarian cancer and the high response rates to chemotherapy, survival has improved little over the last 20 years. The management of patients with ovarian cancer also remains similar despite studies showing striking differences and heterogeneity among different subtypes. It is therefore clear that novel targeted therapeutics are urgently needed to improve clinical outcomes for ovarian cancer. To that end, several membrane receptors associated with pivotal cellular processes and often aberrantly overexpressed in ovarian cancer cells have emerged as potential targets for receptor-mediated therapeutic strategies including specific agents and multifunctional delivery systems based on ligand-receptor binding. This review focuses on the profiles and potentials of such strategies proposed for ovarian cancer treatment and imaging.
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Liu, Huiting, Xiaoqin Wang, Ran Yang, Wenbing Zeng, Dong Peng, Jason Li et Hu Wang. « Recent Development of Nuclear Molecular Imaging in Thyroid Cancer ». BioMed Research International 2018 (2018) : 1–10. http://dx.doi.org/10.1155/2018/2149532.

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Therapies targeting specific tumor pathways are easy to enter the clinic. To monitor molecular changes, cellular processes, and tumor microenvironment, molecular imaging is becoming the key technology for personalized medicine because of its high efficacy and low side effects. Thyroid cancer is the most common endocrine malignancy, and its theranostic radioiodine has been widely used to diagnose or treat differentiated thyroid cancer. This article summarizes recent development of molecular imaging in thyroid cancer, which may accelerate the development of personalized thyroid cancer therapy.
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Tanasova, Marina, Vagarshak V. Begoyan et Lukasz J. Weselinski. « Targeting Sugar Uptake and Metabolism for Cancer Identification and Therapy : An Overview ». Current Topics in Medicinal Chemistry 18, no 6 (28 juin 2018) : 467–83. http://dx.doi.org/10.2174/1568026618666180523110837.

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Metabolic deregulations have emerged as a cancer characteristic, opening a broad avenue for strategies and tools to target cancer through sugar uptake and metabolism. High expression levels of sugar transporters in cancer cells offered glycoconjugation as an approach to achieve enhanced cellular accumulation of drugs and imaging agents, with the sugar moiety anchoring the bioactive cargo to cancer cells. On the other hand, high demand for sugar nutrients in cancers provided a new avenue to target cancer cells with metabolic or sugar uptake inhibitors to induce cancer cells starvation or death. This overview summarizes recent advances in targeting cancer cells through sugar transport for cancer detection and therapy.
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Lalatonne, Y., M. Monteil, H. Jouni, J. M. Serfaty, O. Sainte-Catherine, N. Lièvre, S. Kusmia, P. Weinmann, M. Lecouvey et L. Motte. « Superparamagnetic Bifunctional Bisphosphonates Nanoparticles : A Potential MRI Contrast Agent for Osteoporosis Therapy and Diagnostic ». Journal of Osteoporosis 2010 (2010) : 1–7. http://dx.doi.org/10.4061/2010/747852.

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A bone targeting nanosystem is reported here which combined magnetic contrast agent for Magnetic Resonance Imaging (MRI) and a therapeutic agent (bisphosphonates) into one drug delivery system. This new targeting nanoplatform consists of superparamagneticγFe2O3nanoparticles conjugated to 1,5-dihydroxy-1,5,5-tris-phosphono-pentyl-phosphonic acid (di-HMBPs) molecules with a bisphosphonate function at the outer of the nanoparticle surface for bone targeting. The as-synthesized nanoparticles were evaluated as a specific MRI contrast agent by adsorption study onto hydroxyapatite and MRI measurment. The strong adsorption of the bisphosphonates nanoparticles to hydroxyapatite and their use as MRIT2∗contrast agent were demonstrated. Cellular tests performed on human osteosarcoma cells (MG63) show thatγFe2O3@di-HMBP hybrid nanomaterial has no citoxity effect in cell viability and may act as a diagnostic and therapeutic system.
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Thèses sur le sujet "Cellular Targeting, Imaging and Therapy"

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Nordberg, Erika. « EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy : Preclinical Studies ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8721.

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Steyer, Grant J. « IMAGING OF CARDIOVASCULAR CELLULAR THERAPEUTICS WITH A CRYO-IMAGING SYSTEM ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1271182554.

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Naik, Jay Dolatrai. « Cellular carriers of viral vectors for turmour selective targeting of cancer gene therapy ». Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505080.

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Cancer gene therapy holds promise for patients, yet key issues involving the delivery of vector and achieving tumour selective cytotoxicity, has limited progress over recent years. In this thesis a combination of cell-based carriers, viral vectors and tumour selective promoters are assessed to tackle these two important issues directly. Initially two retroviral systems were considered: intracellular carriage of a rapamycin-inducible retrovirus and extracellular carriage ('hitchhiking') of a self-inactivating (SIN) retroviral vector. Both systems controlled transgene expression using the tumour selective human telomerase reverse transcriptase and telomerase RNA promoters (hTERTp & hTRp). Direct transduction of target cells with SIN marker virus, expressing enhanced Green Fluorescent Protein (eGFP) under the internal control of human telomerase reverse transcriptase promoter (hTERTp) demonstrated similar activity to a positive control virus, with some evidence of telomerase selectivity. Hitchhiking of the same SIN marker vectors also mediated eGFP expression in target cells. In contrast the therapeutic SIN vectors containing suicide transgenes did not achieve a reliable direct telomeraseltumour selective cytotoxic effect, with no discernible toxicity seen with hitchhiked vector. The rapamycin-inducible vectors in contrast to the SIN vectors only demonstrated retroviral genome expression following single cell cloning of a positive-control producer cell line. The retrovirus from this producer successfully mediated low-level target cell eGFP expression, however the data did not support development of therapeutic vectors in,corporating either telomerase promoter. Incorporating oncolytic viruses into the system allowed in vitro therapy. An eGFP expressing oncolytic vesicular stomatitis virus (VSV) and wild-type reovirus, showed direct cytotoxicity against a range of target cell lines. T-cell and non-T-cell peripheral blood mononuclear cell (PBMC) fractions were resistant to both viruses indicating their suitability as oncolytic viral carriers. Finally VSV was successfully hitchhiked on donor T-Iymphocytes leading to the release of VSV .and widespread replication within the malignant Molt-4 cell line.
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Rodrigues, Margret S. Tong Alex W. « Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene ». Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5016.

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Liu, Jian. « POLYMER MODIFICATION OF FULLERENE FOR PHOTODYNAMIC TUMOR THERAPY AND TUMOR IMAGING ». 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120886.

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Calì, Bianca. « Cellular communication and cancer therapy : targeting Ca2+and NO signalling within the tumour microenvironment ». Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423745.

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Cell death and bystander effect are crucial for both the efficacy of cancer therapy and the modulation of anti-tumour immune response. The ‘bystander effect’ refers to a process whereby untreated cells exhibit either the deleterious or beneficial indirect effects as a result of signals received from nearby targeted cells. Various molecular players and pathways have been suggested to mediate the bystander effects, nevertheless to date it is not known which are the key molecules and cellular mechanisms underpinning cell death signal propagation. Several reports suggest the involvement of both nitric oxide (NO) and reactive nitrogen species (RNS) in mediating the bystander effect. Nevertheless their role in the process has not been totally defined since these molecules can either inhibit or sustain tumour progression. Additionally, the methods conventionally applied for NO tracking do neither necessarily reflect real-time NO production nor allow studies into intact three-dimensional tumour mass. The primary aim of this study was to investigate and characterize cell signals responsible for the bystander effect within the tumour microenvironment, paying particular attention to NO. To this purpose, we exploited intravital microscopy by taking advantage of the novel fluorecent probe for NO (CuFL) and the dorsal skinfold chamber model on living tumour-bearing mice subjected to photodynamic therapy (PDT). Notably, the PDT-triggered bystander effect was associated to the generation of very fast NO and Ca2+ waves within the whole tumour mass, supported the hypothesis that constitutive NOS activity might be crucial for the beneficial spread of bystander response and death signals propagation. Additionally, we demonstrated that PDT triggered apoptosis in bystander cells, through gap junction intercellular communication. Finally, our results, provide the first direct evidence of NO involvement in bystander responses within a three-dimensional tumour mass, and strikingly corroborate the notion that connexin gap junction are instrumental for mediating bystander death signals propagation.
La morte cellulare e l’effetto bystander rappresentano degli elementi decisivi per l’efficacia della terapia antitumorale nonchè per la modulazione della risposta immunitaria contro il cancro. Per “effetto bystander” si intende il processo per il quale le cellule non soggette a determinati trattamenti farmacologici subiscono indirettamente gli effetti terapeutici, siano essi positivi o negativi, risultanti dal trattamento esclusivo delle cellule vicine. Nonostante siano state proposte diverse molecole e vie di segnalazione coinvolte nell’effetto bystander, i messaggeri molecolari essenziali ed i meccanismi che sottendono alla propagazione dei segnali di morte non sono ancora noti. Diversi studi suggeriscono un coinvolgimento dell’ossido nitrico (NO) e delle specie reattive dell’azoto (RNS) nell’effetto bystander tuttavia, il loro ruolo nel processo non è tuttora totalmente chiaro, considerato che essi possono sia inibire che sostenere la progressione del tumore. Inoltre, i metodi tradizionalmente usati per lo studio dell’ossido nitrico non riflettono necessariamente la produzione di NO in tempo reale nè consentono studi su complesse masse tumorali tridimensionali. L’obiettivo principale di questo studio è stato quello di individuare e caratterizzare i segnali cellulari responsabili dell’effetto bystander all’interno del microambiente tumorale, rivolgendo particolare attenzione all’NO. A questo scopo, abbiamo utilizzato delle tecniche di microscopia intravitale, avvalendoci di una nuova sonda fluorescente per l’NO (CuFL) e del modello sperimentale delle camerette dorsali impiantate su topi affetti da tumore e sottoposti a terapia fotodinamica (PDT). Da questo studio è emerso che l’effetto bystander indotto dalla terapia fotodinamica è associato alla generazione all’interno della massa neoplastica di onde molto rapide di segnali di NO e di Ca2+. Questi eventi avallano l’ipotesi che l’attività delle isoforme costitutive dell’enzima NOS possa esercitare un ruolo cruciale nella diffusione delle risposte bystander e nella trasmissione dei segnali di morte. Questo lavoro inoltre ci ha consentito di dimostrare che la terapia fotodinamica è in grado di indurre l’apoptosi delle cellule vicine non trattate (bystander) attraverso i meccanismi di comunicazione intercellulare mediati dalle giunzioni comunicanti. Infine, i risultati ottenuti hanno fornito la prima evidenza diretta della partecipazione dell’NO all’effetto bystander all’interno di una massa tumorale tridimensionale e corroborano efficacemente l’ipotesi che le giunzioni comunicanti formate da connesine siano essenziali per garantire la propagazione dei segnali di morte osservati nell’effetto bystander.
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Jing, Ying. « Magnetic nanoparticle tagging and application of magnetophoresis to cellular therapy and imaging ». Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1153422245.

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Mickler, Frauke Martina. « Live-cell imaging elucidates cellular interactions of gene nanocarriers for cancer therapy ». Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-165829.

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Uttamapinant, Chayasith. « Cellular delivery and site-specific targeting of organic fluorophores for super-resolution imaging in living cells ». Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79263.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Recent advances in super-resolution fluorescence microscopy have pushed the spatial resolution of biological imaging down to a few nanometers. The key element to the development of such imaging modality is synthetic organic fluorophores with suitable brightness and photostability. However, organic fluorophores are very difficult to use in live cells because of their chemical compositions. Many excellent fluorophores, such as cyanine and Alexa Fluor dyes, are highly charged with sulfonate groups and do not cross the plasma membrane. Even if the fluorophores get inside cells, there exist few methods that can be used to target these nongenetically encoded probes to specific cellular proteins with high specificity and minimal interference. We describe herein the development of new methods for cellular delivery and sitespecific targeting of organic fluorophores to proteins in living cells. Building on our lab's previous work on engineering new substrate specificity for E. coli lipoic acid ligase (LplA), we created a mutant ligase that catalyzes covalent conjugation of a 7-hydroxycoumarin fluorophore onto a 13-amino acid peptide substrate, called LAP. We showed that enzymatic fluorophore ligation is compatible with the living cell interior and is highly specific for LAP fusion proteins. To extend the repertoire of fluorophores targetable by LplA inside cells, we devised a two-step labeling approach based on enzymatic azide ligation, followed by chemoselective derivatization with any membrane-permeable fluorophore via strain-promoted cycloaddition. As an auxiliary tool for enzymatic probe ligation, we also developed a very efficient and biocompatible variant of copper-catalyzed azide-alkyne cycloaddition that can be used for modification of cell-surface proteins. To overcome the lack of membrane permeability of sulfonated fluorophores, we identified a chemical reaction that efficiently masks charged sulfonate groups as esterase-labile sulfonate esters. Such masked sulfonated fluorophores enter cells readily and can be sitespecifically targeted to intracellular proteins. Our efforts in developing protein labeling and fluorophore delivery methods culminated in their application to super-resolution imaging of cellular proteins in living cells.
by Chayasith Uttamapinant.
Ph.D.
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Persson, Mikael. « Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6798.

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Livres sur le sujet "Cellular Targeting, Imaging and Therapy"

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D, Kumar Rakesh Ph, dir. Molecular targeting and signal transduction. Boston : Kluwer Academic Publishers, 2004.

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Kahn, Michael. Targeting the Wnt pathway in cancer. New York : Springer, 2011.

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D, Kumar Rakesh Ph, dir. Molecular targeting and signal transduction. Boston : Kluwer Academic Publishers, 2004.

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Rakesh, Kumar. Nuclear signaling pathways and targeting transcription in cancer. New York : Humana Press, 2014.

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1953-, Marasco Wayne A., dir. Intrabodies : Basic research and clinical gene therapy applications. Berlin : Landes Bioscience, 1998.

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Targeted cancer therapy : A handbook for nurses. Sudbury, MA : Jones and Bartlett, 2010.

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Stem cell labeling for delivery and tracking using noninvasive imaging. Boca Raton : Taylor & Francis, 2012.

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Kumar, Rakesh. Molecular Targeting and Signal Transduction (Cancer Treatment and Research). Springer, 2004.

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Kraitchman, Dara L., et Joseph Wu. Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging. Taylor & Francis Group, 2011.

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Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging. Taylor & Francis Group, 2020.

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Chapitres de livres sur le sujet "Cellular Targeting, Imaging and Therapy"

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Demchenko, Alexander P. « Phototheranostics : Combining Targeting, Imaging, Therapy ». Dans Introduction to Fluorescence Sensing, 649–91. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-19089-6_17.

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Ryan, Allen F., Lina M. Mullen et Joni K. Doherty. « Cellular Targeting for Cochlear Gene Therapy ». Dans Gene Therapy of Cochlear Deafness, 99–115. Basel : KARGER, 2009. http://dx.doi.org/10.1159/000218210.

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Dürr, Ralf, Oliver Keppler, Frauke Christ, Emmanuele Crespan, Anna Garbelli, Giovanni Maga et Ursula Dietrich. « Targeting Cellular Cofactors in HIV Therapy ». Dans Topics in Medicinal Chemistry, 183–222. Berlin, Heidelberg : Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/7355_2014_45.

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Yanase, Kae, et Toshiwo Andoh. « Cellular resistance to DNA Topoisomerase I-targeting drugs ». Dans DNA Topoisomerases in Cancer Therapy, 129–43. Boston, MA : Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0141-1_7.

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Iqbal, Zafar, Longguang Jiang, Zhuo Chen, Cai Yuan, Rui Li, Ke Zheng, Xiaolei Zhou, Jincan Chen, Ping Hu et Mingdong Huang. « 13 Tumor-specific imaging and photodynamic therapy targeting the urokinase receptor ». Dans Imaging in Photodynamic Therapy, 259–74. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 : CRC Press, 2017. http://dx.doi.org/10.1201/9781315278179-14.

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Villers, Arnauld, et Adil Ouzzane. « Multimodality MRI-Guided Targeting ». Dans Imaging and Focal Therapy of Early Prostate Cancer, 133–40. Totowa, NJ : Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-182-0_10.

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Gooden, C. S. R., et A. A. Epenetos. « Design, Synthesis, and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy ». Dans Targeting of Drugs 5, 107–14. Boston, MA : Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6405-8_11.

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Ahmed, Khalil, Gretchen Unger, Betsy T. Kren et Janeen H. Trembley. « Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach ». Dans Protein Kinase CK2 Cellular Function in Normal and Disease States, 299–315. Cham : Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14544-0_17.

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Hao, Fang, Neelu Yadav et Dhyan Chandra. « Targeting Cellular Signaling for Cancer Prevention and Therapy by Phytochemicals ». Dans Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy, 219–43. New York, NY : Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9326-6_11.

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Ludwig, Wesley W., Mohamad E. Allaf et Dan Stoianovici. « Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy ». Dans Imaging and Focal Therapy of Early Prostate Cancer, 265–73. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-49911-6_20.

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Actes de conférences sur le sujet "Cellular Targeting, Imaging and Therapy"

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Squires, Alexander, John Oshinski et Zion Tsz Ho Tse. « Instrument Guidance System for MRI-Guided Percutaneous Spinal Interventions ». Dans 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3400.

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In Amyotrophic Lateral Sclerosis (ALS), neurons controlling voluntary muscles die, resulting in muscle weakness. Small animal studies have shown that neurons experience some regeneration when stem cells are injected into the ventral horn of the spinal cord [1]. These results led to large animal and human trials investigating the effects of injecting stem cells into the spinal cord. Direct injection is used for delivering cells as cells do not have to migrate to the therapy site and visual confirmation is possible [2]. This requires a multi-level laminectomy as well as dissection of the dura mater to expose the cell delivery site. In order to adopt this ALS treatment in regular clinical workflow, a minimally invasive alternative for spinal cord cell therapy is desirable. Image-guided needle targeting and positioning systems have been developed by numerous groups which use computed tomography or ultrasound for image guidance. However, MRI must be used for this ALS study because it is the only imaging system capable of visualizing the necessary anatomical locations for delivering cellular therapeutics to the spinal cord; the cell therapy target is the gray matter within the ventral horn of the spinal cord, and only MRI can detect the contrast between gray and white matter. Innomotion and NeuroArm have been used for MRI-guided interventions [3, 4] but they are complex, take a long time to set up, and take up a great deal of space in the MRI bore. An initial solution by our research group provided targeting solutions using an adjustable template on the spine, but was manually adjusted, targeted solely on a grid, and lacked a second rotation axis[5]. The presented device, SpinoBot, percutaneously directs therapeutics under MRI guidance into the spinal cord, allowing accurate and minimally invasive spinal therapies. This study examines the accuracy and workflow of MRI-guided cellular therapeutics injections using SpinoBot, a targeting and injection needle guidance system.
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Liu, Tzu-Ming. « Near Infrared Active Nanomaterials for the Theragnosis of Tumors In Vivo ». Dans JSAP-OSA Joint Symposia. Washington, D.C. : Optica Publishing Group, 2017. http://dx.doi.org/10.1364/jsap.2017.5p_a409_6.

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With the engineering of nanomaterials, they become dipolar active to near infrared (NIR) light and form valuable contrasts for deep tissue in vivo imaging at a sub-cellular resolution. The involved physical mechanisms include plasmonic resonance, quantum confinement effects, d-band transition, metal-to-semiconductor transition, bandgap alignment, and lifetime quenching. Some materials can even have multiple contrasts for different molecular imaging modalities like positron emission tomography, magnetic resonance imaging, and computed X-ray tomography. Not only serving as contrast agents in optical microscopy, these materials can also sense the physiological parameters of tumor microenvironment and treat the cancer cells by the photothermal or photodynamic effects. The critical parameters to be sensed include insulin level, oxygen level, and energy metabolism. These NIR imaging tools and molecular probes together provide a theragnosis platform for the study of tumor biology. Especially for the heterogeneous cancer environments, trancing few but important clones like cancer stem cells will be very important for the understanding of their niche environment and the design of targeting therapy. In this presentation, we will show the up-to-date strategies and material systems designed for the theragnosis of tumor. The integrated collaboration among different expertise is required.
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Thomas, Antony, Paige Baldwin et Yaling Liu. « Ultrasound Mediated Enhancement of Nanoparticle Uptake in PC-3 Cancer Cells ». Dans ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93115.

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Ultrasound in the presence of microbubbles brings in transient increase in cell membrane permeability, which allows the entry of foreign molecules into cells. This platform has been applied in in vitro and in vivo gene delivery studies in recent years[1–2]. The frequently used microbubbles are air or inert gas encapsulated in a protein, lipid or polymer which is commonly used as FDA approved contrast agents in diagnostic ultrasound. On exposure to ultrasound the microbubbles lead to formation of small pores on the cell membrane. This work concentrates on application of this platform to enhance cellular uptake of nanoparticles and thereby achieve enhanced drug delivery. Nanoparticles can be manipulated at the nano level and have been applied in the realm of cancer detection and treatment for imaging, targeting tumors, and drug delivery purposes [2].
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Buyukhatipoglu, Kivilcim, Tiffany A. Miller et Alisa Morss Clyne. « Biocompatible, Superparamagnetic, Flame Synthesized Iron Oxide Nanoparticles : Cellular Uptake and Toxicity Studies ». Dans ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68049.

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Superparamagnetic iron oxide nanoparticles, including magnetite (Fe3O4), are widely used in applications such as targeted drug delivery, magnetic resonance imaging, tissue engineering, gene therapy, hyperthermic malignant cell treatment, and cell membrane manipulation. These nanoparticles are particularly interesting for in vivo and in vitro applications since they do not exhibit magnetic behavior once the magnetic field has been removed. In the current work, superparamagnetic iron oxide nanoparticles were produced using a flame synthesis method, which provides significant advantages over other material synthesis processes such as solgel processing, chemical vapor deposition, and laser ablation. Flame synthesis allows control of particle size, size distribution, phase and composition by altering flame operating conditions. Flame synthesis is further capable of commercial production rates with minimal post-processing of the final product materials. This study focuses on the interaction of flame synthesized iron oxide nanoparticles with porcine aortic endothelial cells and compares the results to those obtained using commercially available iron oxide nanoparticles. The materials characteristics of the flame synthesized iron oxide nanoparticles, including morphology, elemental composition, particle size, were analyzed by electron microscopy (TEM, ESEM, EDS), and Raman Spectroscopy. The data verified production of a heterogenous mixture of hematite and magnetite nanoparticles, which exhibit superparamagnetic properties. Monodisperse iron oxide particles of 6–12 nm diameter and aggregated clusters of these 6–12nm nanoparticles have been synthesized. Nanoparticle biocompatibility was assessed by incubating flame synthesized and commercially available iron oxide nanoparticles with endothelial cells for 24 hours. Both alamar blue and Live/Dead cell assays showed no significant toxicity difference between flame synthesized and commercially available nanoparticles. Cells exposed to both types of nanoparticles maintained membrane integrity, as indicated by minimal lactase dehydrogenase release. Endothelial cells imaged by ESEM and confirmed by EDS demonstrated that uncoated flame synthesized nanoparticles are ingested into cells in a similar manner to commercially available nanoparticles. These data suggest that flame synthesized iron oxide nanoparticles are comparable to commercially available nanoparticles for biological applications. Flame synthesis has the advantage of a relatively simple synthesis process with higher purity products and lower time and energy manufacturing costs. Future work will include functionalizing the nanoparticle surfaces for specific biological applications, including specific cell targeting and bioactive factor delivery.
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Skala, Melissa C., Alex J. Walsh, Amy T. Shah, Joseph T. Sharick, Tiffany M. Heaster, Rebecca S. Cook, Carlos L. Arteaga, Melinda E. Sanders et Ingrid Meszoely. « Imaging Cellular Metabolic Heterogeneity in Cancer ». Dans Cancer Imaging and Therapy. Washington, D.C. : OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.jw4a.1.

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Zhou, Quan, Zhao Li, Juan Zhou, Bishnu P. Joshi, Gaoming Li, Xiyu Duan, Rork Kuick, Scott R. Owens et Thomas D. Wang. « EGFR Targeting Photoacoustic Probe for Hepatocellular Carcinoma Imaging in Vivo ». Dans Cancer Imaging and Therapy. Washington, D.C. : OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.cth2a.6.

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Breger, Joyce, James B. Delehanty, Kelly Boeneman Gemmill, Lauren D. Field, Juan B. Blanco-Canosa, Philip E. Dawson, Alan L. Huston et Igor L. Medintz. « Membrane-targeting peptides for nanoparticle-facilitated cellular imaging and analysis ». Dans SPIE BiOS, sous la direction de Wolfgang J. Parak, Marek Osinski et Xing-Jie Liang. SPIE, 2015. http://dx.doi.org/10.1117/12.2077026.

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Mallidi, Srivalleesha, Marvin Xavierselvan, Zhiming Mai et Tayyaba Hasan. « Can photoacoustic imaging to predict cellular photodynamic therapy efficacy ? » Dans Photons Plus Ultrasound : Imaging and Sensing 2021, sous la direction de Alexander A. Oraevsky et Lihong V. Wang. SPIE, 2021. http://dx.doi.org/10.1117/12.2579029.

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Mallidi, S., B. Wang, M. Mehrmohammadi, M. Qu, Y. S. Chen, P. Joshi, S. Kim et al. « Ultrasound-based imaging of nanoparticles : From molecular and cellular imaging to therapy guidance ». Dans 2009 IEEE International Ultrasonics Symposium. IEEE, 2009. http://dx.doi.org/10.1109/ultsym.2009.5441484.

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Lyer, Stefan, Frank Wiekhorst, Rainer Tietze, Jan Zaloga, Christina Janko, Ralf Friedrich, Iwona Cicha et al. « Imaging and quantification of SPIONs for cancer therapy with magnetic drug targeting ». Dans 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). IEEE, 2015. http://dx.doi.org/10.1109/iwmpi.2015.7106996.

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