Bibliographies thématiques / Cancer Cell Imaging - Gold Nanoclusters

Littérature scientifique sur le sujet « Cancer Cell Imaging - Gold Nanoclusters »

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Publié le 7 septembre 2023

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Articles de revues sur le sujet "Cancer Cell Imaging - Gold Nanoclusters"

Chattoraj, Shyamtanu, Md Asif Amin, Saswat Mohapatra, Surajit Ghosh et Kankan Bhattacharyya. « Cancer Cell Imaging Using in Situ Generated Gold Nanoclusters ». ChemPhysChem 17, n^o 1 (23 octobre 2015) : 61–68. http://dx.doi.org/10.1002/cphc.201500731.

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Zheng, Youkun, Weiwei Liu, Yun Chen, Hui Jiang et Xuemei Wang. « Mercaptopyrimidine-directed gold nanoclusters : a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification ». Journal of Materials Chemistry B 6, n^o 22 (2018) : 3650–54. http://dx.doi.org/10.1039/c8tb00791h.

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Kuo, Jui-Chi, Tsung-Rong Kuo, Fajar Rinawati, Erna Susilowati, Sucipto et Dyah Ika Krisnawati. « Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters ». Acta Biochimica Indonesiana 4, n^o 2 (1 mars 2022) : 69. http://dx.doi.org/10.32889/actabioina.69.

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Background: Metal nanoclusters (NCs) with outstanding structural and optical properties have been intensively validated for applications in nanomedicine and nanotechnology. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is overexpressed in many cancer cells. Objective: The gold nanoclusters conjugated with a single domain antibody targeting CEACAM6 of 2A3 (2A3-AuNCs) were synthesized for the inhibition of cancer cells. Methods: 2A3-AuNCs were prepared via a facile hydrothermal approach. The cell viability was measured by resazurin dye reduction assay. The cell death was analyzed by fluorescence imaging. Results: Structural and optical characterizations demonstrated the successful synthesis of 2A3-AuNCs with a roughly spherical shape and a size of 2.35 nm. The 2A3-AuNCs revealed a maximum fluorescence intensity at 350 nm with a fluorescence quantum yield of 4.0%. The cell viability assay indicated that 2A3-AuNCs could inhibit the growths of cancer cells with overexpressed CEACAM6, including breast cancer MDA-MB-231 and MDA-MB-468 cells. The fluorescence imaging results also demonstrated that 2A3-AuNCs could inhibit the growth of cancer cells with MDA-MB-231 and MDA-MB-468 cells. Conclusion: Combination with the results of cell viability assay and fluorescence imaging, the surface ligand of 2A3 antibody on 2A3-AuNCs exhibited promising inhibition of CEACAM6 overexpressed cancer cells. Our work provides a potential application of AuNCs in cancer therapy.

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Wang, Jianling, Leifeng Chen, Jing Ye, Zhiyong Li, Hui Jiang, Hong Yan, Marina Yu Stogniy, Igor B. Sivaev, Vladimir I. Bregadze et Xuemei Wang. « Carborane Derivative Conjugated with Gold Nanoclusters for Targeted Cancer Cell Imaging ». Biomacromolecules 18, n^o 5 (4 avril 2017) : 1466–72. http://dx.doi.org/10.1021/acs.biomac.6b01845.

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Pan, Yiting, Qinzhen Li, Qin Zhou, Wan Zhang, Ping Yue, Changzhi Xu, Ximing Qin, Haizhu Yu et Manzhou Zhu. « Cancer cell specific fluorescent methionine protected gold nanoclusters for in-vitro cell imaging studies ». Talanta 188 (octobre 2018) : 259–65. http://dx.doi.org/10.1016/j.talanta.2018.05.079.

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Lee, Eun Sung, Byung Seok Cha, Seokjoon Kim et Ki Soo Park. « Synthesis of Exosome-Based Fluorescent Gold Nanoclusters for Cellular Imaging Applications ». International Journal of Molecular Sciences 22, n^o 9 (23 avril 2021) : 4433. http://dx.doi.org/10.3390/ijms22094433.

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In recent years, fluorescent metal nanoclusters have been used to develop bioimaging and sensing technology. Notably, protein-templated fluorescent gold nanoclusters (AuNCs) are attracting interest due to their excellent fluorescence properties and biocompatibility. Herein, we used an exosome template to synthesize AuNCs in an eco-friendly manner that required neither harsh conditions nor toxic chemicals. Specifically, we used a neutral (pH 7) and alkaline (pH 11.5) pH to synthesize two different exosome-based AuNCs (exo-AuNCs) with independent blue and red emission. Using field-emission scanning electron microscopy, energy dispersive X-ray microanalysis, nanoparticle tracking analysis, and X-ray photoelectron spectroscopy, we demonstrated that AuNCs were successfully formed in the exosomes. Red-emitting exo-AuNCs were found to have a larger Stokes shift and a stronger fluorescence intensity than the blue-emitting exo-AuNCs. Both exo-AuNCs were compatible with MCF-7 (human breast cancer), HeLa (human cervical cancer), and HT29 (human colon cancer) cells, although blue-emitting exo-AuNCs were cytotoxic at high concentrations (≥5 mg/mL). Red-emitting exo-AuNCs successfully stained the nucleus and were compatible with membrane-staining dyes. This is the first study to use exosomes to synthesize fluorescent nanomaterials for cellular imaging applications. As exosomes are naturally produced via secretion from almost all types of cell, the proposed method could serve as a strategy for low-cost production of versatile nanomaterials.

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Qiao, Juan, Xiaoyu Mu, Li Qi, Jingjing Deng et Lanqun Mao. « Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging ». Chemical Communications 49, n^o 73 (2013) : 8030. http://dx.doi.org/10.1039/c3cc44256j.

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Chattoraj, Shyamtanu, Md Asif Amin, Saswat Mohapatra, Surajit Ghosh et Kankan Bhattacharyya. « Inside Cover : Cancer Cell Imaging Using in Situ Generated Gold Nanoclusters (ChemPhysChem 1/2016) ». ChemPhysChem 17, n^o 1 (janvier 2016) : 2. http://dx.doi.org/10.1002/cphc.201501148.

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Ye, Jing, Tianxiang Hu, Yanqi Wu, Hui Chen, Qianqian Qiu, Rongqing Geng, Hui Ding et Xiaojuan Zhao. « Near-Infrared Liposome-Capped Au-Rare Earth Bimetallic Nanoclusters for Fluorescence Imaging of Tumor Cells ». Journal of Biomedical Nanotechnology 18, n^o 9 (1 septembre 2022) : 2113–22. http://dx.doi.org/10.1166/jbn.2022.3423.

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Early detection of cancer can effectively improve the survival rate of cancer patients. Fluorescence imaging has the advantages of high sensitivity and rapid imaging, and is widely used in the precise imaging detection of tumors. In this study, five kinds of Au-rare earth bimetallic nanoclusters (Au/Ln NCs) were prepared by template method using five representative rare earth elements doped with gold. The morphologies, surface charges, sizes, fluorescence quantum yields and maximum fluorescence emission wavelengths of these five kinds of Au/Ln NCs were characterized and contrasted. The findings indicated that the Au/Ce nanoclusters (Au/Ce NCs) prepared by Ce doping have the longest fluorescence emission wavelength (695 nm) and higher quantum yield, which could effectively avoid the interference of autofluorescence, and was suitable for fluorescence imaging of tumor cells. In order to improve the specific accumulation of nanoclusters in tumor cells, Au/Ce NCs were coated with folic acid modified liposomes (lip-FA) to constructed a targeted fluorescent imaging probe with near-infrared response (Au/Ce@lip-FA), which was successfully used for fluorescence imaging of tumor cells. The probe has the characteristics of stable fluorescence signal, good targeting, easy internalization, and safe metabolism, and can provide high-resolution and high-brightness imaging information, which is expected to play an important role in the clinical diagnosis and surgical treatment of tumors.

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Wang, Chensu, Jingyuan Li, Christian Amatore, Yu Chen, Hui Jiang et Xue-Mei Wang. « Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells ». Angewandte Chemie International Edition 50, n^o 49 (11 octobre 2011) : 11644–48. http://dx.doi.org/10.1002/anie.201105573.

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Thèses sur le sujet "Cancer Cell Imaging - Gold Nanoclusters"

Huang, Xiaohua. « Gold Nanoparticles Used in Cancer Cell Diagnostics, Selective Photothermal Therapy and Catalysis of NADH Oxidation Reaction ». Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/10565.

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Gold nanoparticles strongly absorb and scatter visible and near infrared light because of the strongly enhanced electric fields at the surface. This provides the potential of designing novel optically active reagents for simultaneous molecular imaging and photothermal cancer therapy. In this thesis, gold nanospheres and nanorods conjugated with anti-epidermal growth factor receptor (anti-EGFR) antibodies that specifically target EGFR on the cell surface are shown to be used for dual diagnostics and therapy. Using micro-absorption spectroscopy and light scattering imaging, cancerous (HOC 313 and HSC 3) and noncancerous cells (HaCat) can be differentiated due to the overexpression of EGFR on the surface of cancer cells. By irradiating the cells with a CW laser, selective photothermal cancer therapy is realized in visible region by using gold nanospheres and in near infrared region by using gold nanorods. The use of nanorods allow for in vivo therapy due to the fact that their absorption is in the near infrared region at which the laser light meets less interference from the tissue absorption. In addition, the catalytic effect of gold nanoparticles on the oxidization of NADH to NAD+ is investigated. The addition of gold nanoparticles is found to quench the NADH fluorescence intensities but has no effect on the fluorescence lifetime. This suggests that the fluorescence quenching is not due to coupling with the excited state, but due to changing the ground state of NADH. The intensity of the 340 nm absorption band of NADH is found to decrease while that of the 260 nm band of NAD+ is found to increase as the concentration of gold nanoparticles increase. This conversion reaction is further supported by nuclear magnetic resonance and mass spectroscopy. The linear relationship between the initial reaction rate of NADH and the concentration of gold nanoparticles strongly supports that NADH is surface catalyzed by the gold nanoparticles. The catalytic property of this important reaction might have important future applications in biological and medical fields.

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TERRACCIANO, ROSSANA. « Enhancing the Biodistribution and Physicochemical Properties of Gold Nanoparticles by Modifying their Surface Characteristics ». Doctoral thesis, Politecnico di Torino, 2023. https://hdl.handle.net/11583/2976597.

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Chapitres de livres sur le sujet "Cancer Cell Imaging - Gold Nanoclusters"

Balakrishnan, Solaimuthu, Firdous Ahmad Bhat et Arunakaran Jagadeesan. « Applications of Gold Nanoparticles in Cancer ». Dans Biomedical Engineering, 780–808. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3158-6.ch035.

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This chapter deals with the applications of gold nanoparticle in cancer and various strategies to target cancer cells by using gold nanoparticles. They are in great demand for biomedical applications such as DNA/Protein detection, bimolecular regulators, cell imaging and cancer cell diagnostics. The ability to tune the surface of the particle provides access to cell –specific targeting and controlled drug release. Depending on their size, shape, degree of aggregation, and local environment, gold nanoparticles can appear red, blue, or other colors. The novel drug delivery systems offer the opportunity to improve poor solubility, limited stability, bio distribution, and pharmacokinetics of drug as well as offering the potential ability to target specific tissues and cell types. The multifunctional gold nanoparticles are attractive organic –inorganic hybrid material composed of an inorganic metallic gold core surrounded by an organic or bimolecular monolayer they provide desirable attributes for the creation of drug delivery in cancer.

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Balakrishnan, Solaimuthu, Firdous Ahmad Bhat et Arunakaran Jagadeesan. « Applications of Gold Nanoparticles in Cancer ». Dans Integrating Biologically-Inspired Nanotechnology into Medical Practice, 194–229. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0610-2.ch008.

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Choudhury, Ananya, et Peter Hoskin. « Urological cancers ». Dans Imaging for Clinical Oncology, 168–92. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198818502.003.0014.

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Prostate cancer is the most common cancer in males. There have been significant advances in imaging over the past decade, leading to improvements in diagnosis, staging, response assessment, and patient follow-up. This chapter covers urological cancers, including prostate cancer, bladder cancer, upper urinary tract urothelial tumours, testicular cancer, penile cancer, renal cell carcinoma, and urethral cancer. The current gold standard in imaging is discussed, with a look at imaging modalities on the horizon which are likely to impact cancer treatment in the next few years. Ultrasound, cross-sectional and radioisotope imaging all have a place in the management of urological cancers and radiotherapy planning.

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Bhat, Firdous Ahmad, Balakrishnan S et Arunakaran J. « Applications of Nanotechnology in Cancer ». Dans Advances in Environmental Engineering and Green Technologies, 184–217. IGI Global, 2015. http://dx.doi.org/10.4018/978-1-4666-6304-6.ch007.

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This chapter examines the importance of nanotechnology in cancer prevention, cure, and diagnosis. This chapter deals with the applications of nanomedicine in cancer and various strategies to target cancer cells by using nanotechnology such as gold nanoparticles, liposomes, nanodots, nanorods, etc. Nanotechnology is an interdisciplinary area with potential applications in fighting many diseases including cancer. Conventional drugs have poor cell specificity, solubility, and high toxicity. The continued development of cancer nanotechnology holds the promise for personalized oncology. For accurate and self-confirming cancer diagnosis, it is essential to combine dual-mode and multi-mode imaging functionalities within one nanoparticle system. Nanoparticles improve the solubility of poorly water-soluble drugs and prolong the half-life of drugs. Disadvantages of nanotechnology include the potential for mass poisoning. Understanding how nano-materials affect live cell functions, controlling such effects, and using them for disease therapeutics are now the principal aims and most challenging aspects of nanobiotechnology and nanomedicine.

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Actes de conférences sur le sujet "Cancer Cell Imaging - Gold Nanoclusters"

Wu, Yue, Moustafa R. Ali, Ning Fang et Mostafa A. El-Sayed. « Abstract LB-365 : Microscopic imaging for understanding gold nanorods-protein interactions in inhibiting cancer cell migration ». Dans Proceedings : AACR Annual Meeting 2018 ; April 14-18, 2018 ; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-lb-365.

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Manuchehrabadi, N., A. Attaluri, H. Cai, R. Edziah, E. Lalanne, C. Bieberich, R. Ma, A. M. Johnson et L. Zhu. « Visualization and Quantification of Gold Nanorods Distribution in Prostatic Tumors Using MicroCT Imaging ». Dans ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80317.

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One uncertainty in use of gold nanorods for laser photothermal therapy is the non-uniform spreading of gold nanorods in tissue after either systemic delivery or intratumoral injections. High concentration of gold nanorods in certain areas influences the resulted optical absorption of the laser and thermal damage to tumors. This also provides challenges in designing optimal heating protocols via modeling thermal transport in laser photothermal therapy. For successful cancer treatment, the tissue should be heated with minimum thermal dosage to induce tumor cell damage, while minimizing overheating in the surrounding healthy tissues. Thus, one of the main challenges for reliable cancer therapy is to precisely control loading and distribution of gold nanorods in the tumour tissue. The critical mass transport processes are the distribution of gold nanorods after injection to the tumor and the redistribution of gold nanorods during laser treatment. Since tumors are opaque, nanostructure distribution in tissue is often studied either by theoretical modeling approaches1, or via dye enhanced imaging on superficial layers of tumors.2 It is important to find a technique which can directly visualize and analyze three-dimensional nanostructure distribution of tumors. Three-dimensional reconstructions of tumors with the ability to trace gold nanorod spreading have the potential for precise theoretical simulation of temperature fields. Previous studies showed that computer tomography (CT) scan is a promising technique to be utilized to characterize the distribution of intratumorally injected magnetic nanoparticles in tumors 3.

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