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1
Garcia, Rosselló Jaume. « Análisis traceológico de la cerámica : modelado y espacio social durante el postalayótico (V-I A.C.) en la Península de Santa Ponça (Calvià, Mallorca) ». Doctoral thesis, Universitat de les Illes Balears, 2010. http://hdl.handle.net/10803/291944.
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La tesis doctoral que presentamos a continuación bajo el título: “Análisis traceológico de la cerámica: modelado y espacio social durante el postalayótico (V-I A.C.) en la Península de Santa Ponça (Calvià, Mallorca) tiene una doble orientación: Por una parte es una nueva propuesta metodológica fundamentada en la reconstrucción de los sistemas de modelado por medio de la traceología cerámica. Por otro, es una aplicación metodológica sobre un conjunto de cerámicas adscritas a la edad de hierro y procedentes de diferentes yacimientos del sur de la isla de Mallorca.
En este sentido, los datos e interpretaciones que aquí se exponen son deudores de una línea de investigación sobre tecnología cerámica que inició un joven equipo de investigadores de la universidad de las Islas Baleares allá por el año 1999. Se trata por tanto de una propuesta que siguiendo una línea de investigación ya consolidada en la Universidad de las islas Baleares a través del grupo de investigación arqueobalear, desarrolla un nuevo método de análisis del modelado cerámico fundamentado en la identificación de las macrotrazas de manufactura presentes en las vasijas cerámicas. Se trata de una metodología que debe enmarcarse dentro de las recientes propuestas de la arqueología francófona orientadas a identificar las técnicas y procesos de modelado a través de la traceología cerámica. En este trabajo, al igual que ocurre con otros que hemos ido publicando, se propone un modelo teórico-analítico basado en el concepto de cadena operativa en el que encuadrar la secuencia de operaciones técnicas documentadas.
Sin embargo, estamos convencidos, que identificar los sistemas de fabricación no debería ser el fin último de un trabajo arqueológico. Saber cómo se fabrica una vasija no pasa de lo anecdótico si no la insertamos en su contexto y empleamos los estudios tecnológicos para inferir comportamientos sociales.
Como conclusión planteamos que, el modelado, más que otras fases de la cadena operativa, está fuertemente imbricado en los procesos de aprendizaje y en las dinámicas sociales. A partir de esta premisa hemos podido establecer que la alta variabilidad en las cadenas operativas permite visualizar una fragmentación de los procesos de aprendizajes que tendría mucho que ver con la progresiva desestructuración social que sufre la sociedad indígena durante las postrimerías de la influencia púnica en la islaThe PhD thesis here presented with the title Traceological Analysis of Pottery: Modelling and Social Space during the post-Talayotic (5st-1st century BC) in Santa Ponça Peninsula (Calvià, Mallorca) (v.gr. Análisis traceológico de la cerámica: modelado y espacio social durante el postalayótico (V-I BC) in Santa Ponça Peninsula (Calvià, Mallorca)) was developed under a twofold orientation. On the one hand, it constitutes an innovative methodological proposal grounded on the reconstruction of modelling systems by means of ceramic traceology. On the other hand, this methodology is exemplified on a pottery assemblage dated to the Iron Age which was recovered in several sites in southern Mallorca. Hence, both the data and the interpretations discussed are heir to a research line on ceramic technology set up by a young research team from the University of the Balearic Islands, Arqueobalear, around 1999. The proposal follows the research line already consolidated in the aforementioned university while expanding on a new analytical method for the analysis of pottery modelling by identifying the macrotraces present on ceramic vessels. The methodology used should thus be framed on the recent proposals of French-speaking archaeology, which is interested in recording modelling techniques and processes using ceramic traceology. In this way, the research work presented here, in line with previous publications, enlarges on a theoretical-analytical model based on the concept of châine opératoire which defines the sequence of technical operations documented. However, it is further assumed that the identification of modelling systems should not be regarded the ultimate aim of an archaeological research. Knowing how a vessel was made is not more than an anecdote unless it is embedded in its social context, as technological studies should be used to infer social behaviours. Finally, it may be concluded that modelling, even more than the remaining phases of the châine opératoire, is highly imbricated in learning processes and social dynamics. From this premise, it can be stablished that the large variability detected in the châine opératoire makes visible the fragmentation of the learning processes, a fact closely related to the progressive social disintegration of the indigenous society at the close of the Punic influence on the island.
2
Haines, Alexander S. « Calvin and Conciliation ». Scholarship @ Claremont, 2010. http://scholarship.claremont.edu/cmc_theses/220.
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The popular conception of John Calvin today is as a divisive figure within Christianity, who vehemently opposed some beliefs while demanding rigid acceptance of others. In this thesis, I intend to investigate the accuracy of that conception by exploring how Calvin approached ecumenicalism theologically and practically. This will cover Calvin's understanding of the Church, his cooperation and disagreements with other Christians, and evaluate what Calvin might contribute to an ecclesiology useful for the Church today. Calvin has gained a poor reputation in modern times both for participation in historical events, including the execution of Servetus, and also for the association of Calvin with the Calvinism that arose after his death in the Netherlands and then in the United States. Calvin is associated with a strong anti-secularism, rigid doctrine (particularly arising out of five point Calvinism), exclusive claims with strictly delineated in and out groups, and ultimately with conservative Christians who are frequently perceived as theocratic far right-wingers. These perceptions stand somewhat, although not fully, in contrast to the very human John Calvin, whose work was frequently designed to build up the Christian Church.
3
Barrier, Alice Ce´cile Madeleine. « Effects of a difficult calving on the subsequent health and welfare of the dairy cows and calves ». Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6527.
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Yearly calvings are essential to the sustainability of modern dairy farming. Currently, calving difficulty (or dystocia) affects one in six calvings among UK dairy herds but vary from 2 to 50% internationally. In dairy cows, despite reports of impaired performance, the extent and threshold of the effect of dystocia on health and performance remains unclear. Over the past years, there has also been increasing concerns about the levels of pain experienced by the dystocial cows. Better understanding of their parturition progress and behaviours is needed so that informed decisions on pain mitigation can be taken. Additionally, the impact of dystocia (besides stillbirth) should also be addressed in dairy calves. The objective of this study was to address the effects of a difficult calving on the health and welfare of both dairy cows and calves. Retrospective analyses of an experimental farm’s detailed records were used to relate calving difficulty with health and performance of the dairy cow. The results showed that after any difficulty at calving, dairy producers incur long-lasting shortfalls in milk sales. Dystocial cows also have impaired fertility, are more likely to leave the herd early and have a higher risk of dystocia at the following calving, thus there is a long-term detrimental impact on dystocial cows. Video monitoring of calvings allowed detailed investigation of the parturition progress and behaviours of dystocial Holstein cows giving birth to singleton liveborn calves. The study of calving behaviours and parturition progress indicated longer later stages of parturition, increased restlessness and tail raising in the six hours preceding expulsion of the calf, for dystocial cows receiving farm assistance compared with cows calving unaided. This may relate to the expression of higher levels of pain when dystocia occurs. The onset of maternal behaviour was not delayed following calving difficulty, and firm conclusions could not be drawn from investigation of some behavioural indicators of pain in the first three hours postpartum. Experimental work allowed the monitoring of a cohort of 496 calves born with various degrees of birth difficulty over two years. All but one vet assisted calves were born dead, and farmer assisted calves were more likely to be stillborn than calves born without assistance. Stillborn dystocial calves displayed larger internal damage, than stillborn eutocial calves, but they did not have a different body shape at birth than dystocial calves that survived. Dystocial dairy calves that survived the birth process had lower vigour at birth, had higher salivary cortisol, acquired lower passive immunity and received more health treatments in the neonatal period. Dystocial heifers also had higher mortality rates by weaning but had similar growth to first service. Historical records from the farm also showed that dystocial heifer calves were three times more likely to have died by weaning and by first service than calves born without assistance. For those who survived, there was, however, no indication of altered growth to weaning or subsequent impaired fertility. This may be explained by the early mortality of the most badly affected calves or by farm management. However, their high mortality rates still raise welfare concerns. Altogether, results suggest that dairy calves born with any difficulty have poorer welfare in the neonatal period and possibly beyond. The experience of any calving difficulty in dairy cattle therefore not only impairs the welfare of the cow, but also the welfare from their resulting calf. Any strategy implemented to lower the occurrence and mitigate the effects of dystocia will therefore improve the welfare of the cows, their calves and enhance the farm’s economic sustainability.
4
Choi, Sung Rual. « Union with Christ ? : re-reading Calvin as constructive proposal for Korean Calvin reception ». Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97797.
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Thesis (PhD)--Stellenbosch University, 2015.ENGLISH ABSTRACT: The starting point of this dissertation is the presence of a theological deficit regarding the reception of Calvin’s “union with Christ (unio cum Christo)” thought. It is argued that the notion of “union with Christ” should not be treated merely as a doctrinal theme within soteriology and the doctrine of the Sacraments but as having an interrelationship with various other important doctrines in Calvin’s theology, thus functioning as a core thought. Hence this dissertation re-interprets and re-evaluates the original scope, content and meaning of Calvin’s use of the notion of “union with Christ,” attending in the process to the various metaphorical expressions and theological meanings associated with this notion. This research dissertation attempted to recover the importance of what is described as Calvin’s “union with Christ” thought in the following manner. Firstly, it examines the main causes for the reduction of the scope and importance of “union with Christ” thought in Korean Reformed theology and the American Reformed theology (or Calvinistic theology) that influenced it. Secondly, it also examines more concretely the various metaphorical expressions and theological meanings associated with “union with Christ” thought. Lastly, the study strives to verify systematically that the “union with Christ” thought (or ‘union with the Triune God’ thought) functions as a core thought in Calvin’s theology. This is done through the explication of the close inter-relationship between the structure of the Institutes and “union with Christ” thought, as well as by indicating the way in which “union with Christ” thought is interrelated with other important doctrines in Calvin’s theology.
AFRIKAANSE OPSOMMING: Die vertrekpunt van hierdie verhandeling is die stelling dat daar in gereformeerde teologie ‘n reduksie ten opsigte van Calvyn se gedagte van die unio cum Christo (die eenheid of vereniging met Christus) bestaan. Die studie argumenteer dat “eenheid met Christus” nie alleenlik as ‘n leerstellige tema binne die soteriologie en die leerstelling oor die sakramente in Calvyn se teologie beskou moet word nie, maar dat die interrelasie van hierdie tema met ander belangrike leerstellige temas deeglik en duidelik verreken moet word. “Eenheid met Christus” funksioneer dus as ‘n kerngedagte in Calvyn se teologie. Daarom herinterpreer en herevalueer hierdie proefskrif die oorspronklike reikwydte, inhoud en betekenis van Calvyn se gebruik van die “eenheid met Christus”- gedagte, en in die proses word onder meer in fyn besonderhede aan die onderskei metaforiese uitdrukkings en teologiese temas wat met hierdie gedagte gepaardgaan, aandag gegee. Die navorsing poog in die proses om die belangrikheid van Calvyn se “eenheid met Christus”-gedagte te herontdek langs die volgende weë: Ten eerste word daar gekyk na die reduksie in reikwydte, betekenis en belangrikheid van Calvyn se “eenheid met Christus”- gedagte in Koreaanse gereformeerde teologie, sowel as in die Amerikaanse gereformeerde (of Calvinistiese) teologie wat so ‘n groot impak daarop gehad het. In die tweede plek word daar heel konkreet en in groot detail na die onderskeie metaforiese uitdrukkings en teologiese betekenisse wat met die “eenheid met Christus”-gedagte geassosieer word, ondersoek ingestel. Derdens poog die studie om oortuigend op ‘n sistematiese wyse aan te toon dat “eenheid met Christus” as ‘n kerngedagte in Calvyn se teologie funksioneer. Dit word gedoen deur aan te toon dat daar ‘n noue interrelasie tussen die struktuur van die Institusie en die “eenheid met Christus”-gedagte is, sowel as deur die noue interrelasie tussen hierdie gedagte en ander belangrike dogmatiese loci in Calvyn se teologie aan te dui.
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Hunter, Alissa L. « Association of Serum Calcium Status at Calving on Survival, Health, and Performance of Post-partum Holstein Cows and Calves ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429743557.
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Islam, Md Nurul. « The effects of pre-calving nutrition on the performance of single and twin pregnant beef cows and their calves ». Thesis, University of Aberdeen, 1988. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU010517.
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Three experiments were carried out to assess the energy and protein requirments of single and twin-bearing beef cows during the last three months of pregnancy and also to observe the effects of pregnancy nutrition on the subsequent lactational performance of cows and calves. A wide range of energy level was applied to single and twin-bearing cows. As assessed from body weight change, calf birthweight, milk yield, calf growth rate and blood parameters, it was found that there was no benefit in giving high levels of dietary energy to cows during pregnancy. It was concluded that feeding 50 and 70 MJ ME/day to single and twin-bearing cows respectively together with a high proportion of UDP may be acceptable levels during the latter part of gestation, provided that the cows are in good body condition at the start of the last trimester of pregnancy and they are given adequate nutrition during early lactation. Another three experiments were conducted with pregnant ewes, wethers, pregnant heifers and steers to measure the digestibility and to determine the metabolisable energy value of two mixed diets which differed in rumen degradability of protein. Such diets were used in experiments with pregnant cows. A comparison was made between the digestive capacity in different species and sex of animals. Digestibility co-efficients of two diets, two sexes and two species did not differ significantly. Therefore, it was concluded that metabolisable energy value determined for mixed diets using sheep can be used for cattle. ME value of mixed diets was less than that calculated in these experiments but the extent of the decrease may be acceptable under farm conditions.
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Balke, Willem. « Calvin and the Anabaptist Radicals / ». Ann Arbor [Mich.] : UMI-Books on demand, 1998. http://catalogue.bnf.fr/ark:/12148/cb37006352v.
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Blacketer, Raymond Andrew. « The school of God : pedagogy and rhetoric in Calvin's interpretation of deuteronomy / ». Dordrecht : Springer, 2006. http://www.loc.gov/catdir/enhancements/fy0824/2007440798-d.html.
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Chiarot, Kevin. « Calvin, the papacy, and the ascension ». Theological Research Exchange Network (TREN) Access this title online Theological Research Exchange Network (TREN), 2007. http://www.tren.com.
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Chong, Kenneth Tze Aun School of English UNSW. « Donne???s Holy Sonnets and Calvin ». Awarded by:University of New South Wales. School of English, 2006. http://handle.unsw.edu.au/1959.4/26154.
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Criticism on Donne???s Holy Sonnets has traditionally been concerned with trying to find an explanation for the doubt, anxiety, and despair that is often expressed by the speaker of those poems. In recent decades, critics have increasingly made recourse to Calvinist theology in an effort to explain these melancholy states of mind. The accounts that such critics provide of ???Calvinism,??? however, have been varied and largely inadequate, mainly because they fail to engage with Calvin???s work at the level it requires. My thesis seeks to correct such deficiencies by providing a detailed reading of Calvin???s view on salvation and the way in which it is received. Calvin argues that we obtain salvation through a firm and certain faith, a faith that is nevertheless attacked by the unbelief that still resides in the believer. In other words, there is a division between the flesh and the spirit within the soul of the believer, which means that he or she is never free (until death) from the sinful temptations of this life. This division, which Calvin invokes to reconcile the uncertainties of the Christian life with the assurance of faith, is dramatised in the Holy Sonnets. In the five poems that I analyse, the speaker is torn between a desire for righteousness and an inclination toward evil, a division that is also represented in the structural qualities of the text. The various temptations which the speaker registers and confronts (and often falls to) are, I believe, a demonstration of Calvin???s view that the regenerate person is in continuous warfare against the remnants of the flesh.
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Spicer, Nellie Mae. « Theological reflection with Calvin and Hobbes ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ55446.pdf.
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Roberts, Dean Edward Giraud. « Calvin, Anabaptism, and the visible church ». Theological Research Exchange Network (TREN), 1991. http://www.tren.com.
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Piva, Daniel. « Convergências e divergências conceituais sobre o livre arbítrio em Santo Agostinho e Calvino ». Universidade Presbiteriana Mackenzie, 2010. http://tede.mackenzie.br/jspui/handle/tede/2546.
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Previous issue date: 2010-02-23In this work the author begins with a short historic introduction about Saint Augustine, John Calvin and Free Will in order to deal specifically with their similarities and differences concerning this subject. His goal is to contribute to a larger understanding about the human will and its limitations from the perspective of Science of Religion, thus enlarging the field of knowledge of the humanities.
Neste trabalho o autor faz uma pequena introdução histórica sobre Santo Agostinho, João Calvino e o tema Livre-Arbítrio para tratar especificamente das convergências e divergências entre estes dois teólogos sobre o referido tema. Seu objetivo é contribuir para o maior entendimento sobre a questão da vontade humana e suas limitações sob o ponto de vista das Ciências da Religião, ampliando assim o campo do conhecimento das humanidades.
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Poolman, Mark Graham. « Computer modelling applied to the Calvin Cycle ». Thesis, Oxford Brookes University, 1999. http://radar.brookes.ac.uk/radar/items/23a3e616-7ec2-6ace-9ab0-9b266a9a61f8/1.
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This thesis developes computer modelling techniques, and their use in the investigation of biochemical systems, principally the photosynthetic Calvin cycle. A set of metabolic modelling software tools, "Scampi", constructed as part of this project is presented. A unique feature of Scampi is that it allows the user to make a particular model the subject of arbitrary algorithms. This provides a much greater flexibility than is available with other metabolic modelling software, and is necessary for work on models of (or approaching) realistic complexity. A detailed model of the Calvin cycle is introduced. It differs from previously published models of this system in that all reactions are assigned explicit rate equations (no equilibrium assumptions are made), and it includes the degradation, as well as the synthesis, of starch. The model is later extended to include aspects of the thioredoxin system, and oxidative pentose phosphate pathway. Much of the observed behaviour is consistent with experimental observation. In particular, Metabolic Control Analysis of the model shows that control of assimilation flux is likely to be shared between two enzymes, rubisco and sedoheptulose bisphosphotase (SBPase), and can readily be transferred between them. This appears to offer an explanation of experimental evidence, obtained by genetic manipulation, that both of these enzymes can exert high control over assimilation. A further finding is that the output fluxes from the cycle (to starch and the cytosol), show markedly different patterns of control from assimilation, and from each other. An novel observation in behaviour of the Calvin cycle model is that, under certain circumstances, particularly at low light levels, the model has two steady-states and can be induced to switch between them. Although this exact behaviour has not been described experimentally, published results show charecteristics suggesting the potential is there in vivo. An explanation of all the observed behaviour is proposed, based upon the topology of the model. If this is correct then it may be concluded that the qualitative behaviour observed in the model is to be expected in vivo, although the quantitative detail may vary considerably.
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Chang, Paul. « John Calvin on the doctrine of assurance ». Theological Research Exchange Network (TREN), 1992. http://www.tren.com.
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Meneghello, Helena Coimbra. « Italo Calvino ». Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/94790.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2011Made available in DSpace on 2012-10-25T16:17:53Z (GMT). No. of bitstreams: 1 296716.pdf: 523542 bytes, checksum: 1e9159d076cd052f50634ee04ef4b73f (MD5)
Este trabalho tem como objetivo discutir o pensamento de Italo Calvino a respeito da tradução literária. Ele estuda especificamente as reflexões do autor sobre tradução, contidas em alguns de seus ensaios críticos selecionados para esta pesquisa, e também na metalinguagem do romance Se um viajante numa noite de inverno (1990). O que se quer é identificar e discutir quais são, na concepção do autor, as potencialidades e as limitações da tradução na sua relação com a literatura.
The present work intends to discuss the thought of Italo Calvino concerning translation of literary works. It specifically studies the reflections of the author on translation as expressed in his critical essays selected for this research and in the metalinguistic novel If on a winter's night a traveler (1981). The main objective of this work is to identify and to discuss the author.s conceptions on potentials and limitations of translation in its relation with literature.
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Assonville, Victor E. d'. « Der Begriff "doctrina" bei Johannes Calvin : eine theologische Analyse / ». Münster : Lit, 2001. http://catalogue.bnf.fr/ark:/12148/cb38880569v.
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Elonheimo, Kalle. « Das universale Recht bei Johannes Calvin : mit besonderer Berücksichtigung seines Naturrechtsverständnisses / ». Åbo : Åbo akademis förlag, 2006. http://catalogue.bnf.fr/ark:/12148/cb401774226.
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Michels, Andreas. « Untersuchungen zur Regulation des Calvin-Zyklus in Kieselalgen ». [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=963944622.
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Johnson, Ronn. « John Calvin on the original state of man ». Theological Research Exchange Network (TREN), 1990. http://www.tren.com.
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Wegener, David Jonathan. « In principio John Calvin on scripture and science / ». Theological Research Exchange Network (TREN) Access this title online, 1989. http://www.tren.com.
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Wegener, David Jonathan. « I̲n̲ p̲r̲i̲n̲c̲i̲p̲i̲o̲ John Calvin on scripture and science / ». Theological Research Exchange Network (TREN), 1989. http://www.tren.com.
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Song, Yong Won. « Common good in the theology of John Calvin ». Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6433.
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The aim of my thesis is to explore Calvin's understanding of the term „the common good‟ (commune bonum, bien commun): its theological grounding within his works, and its role as an inspiration for both ecclesial and social application. I seek to illustrate how his notion of the common good is constructed theologically (part A) and practically (part B). Although Calvin‟s notion of the common good has been partly dealt with by numerous scholars (mainly from a variety of socio-economic perspectives), there has been no comprehensive or systematic study to illustrate its theological significance and its doctrinal context. The aim of this study is to illuminate the wide-ranging and consistent thought on the common good discernable within Calvin‟s works; it is hoped that this indepth study of the topic will be a valuable addition to Calvin scholarship. The structure of Part A reflects how Calvin‟s three theological foundations - God‟s image, sanctification, and Law - are shaped dynamically through the three stages of humankind‟s salvation - before the Fall, after the Fall, and in Christ‟s redemption. Chapters Two - Four show how these theological foundations operate towards the restoration of God‟s original order designed for the common good in the correlation between the two fields of church and humankind, both at the divine and moral level and the spiritual and social level. In addition, the willingness and mutuality which constitute the cornerstone of Christ‟s redemption are decisive in the realization of the common good. Chapter Two argues, first, that Calvin‟s notion of the common good, drawn from his doctrine of God‟s image, is shaped by the threefold dimension of that image - the relational, substantial, and communal. For the restoration of the original order in God's creation, the universal love of humankind based upon the surviving substantial-communal image of God in humanity plays a limited part; however, the Christian‟s sanctified universal love based upon the restored relational-communal image of God in Christ plays a pivotal role. With relation to the restored image in Christ, Chapter Three shows that the most essential element of sanctified life for participating in the divine economy for the common good within the Trinitarian mode is Christian self-denial; that is, the composition of the present life designed for eternal life through the multiple sub-analyses of Christ‟s example, consecration, humility, and stewardship. Chapter Four shows how Calvin‟s integrated legalistic approach, in terms of the common good, can help us to explore another facet of his multiple understanding of God‟s image in humanity with regards to both ecclesial and social life. For Calvin, the three uses or functions of the Law can be regarded as both distinctively and inseparably incorporated into work for the common good of all people. In relation to the Law in Christ, Christian freedom can be analyzed from pedagogical, responsive, and pastoral perspectives in terms of the life for the common good. As the Decalogue is a spiritual-moral space within the mutual function of the third use and second use of the Law, Calvin‟s understanding of the two tablets demonstrates how his interpretation of both divine and natural law in terms of the common good can be co-embodied in the right relation between God and humanity and amongst people. With the above theological background in mind, Part B of this thesis, through Chapters Five and Six, continues to elucidate how, for Calvin, the notion of „the common good‟ reveals its value when it is established within the divine system of voluntary giftgiving, where it can engage with the mutual relation of the common good of the church and the common good of humankind. Calvin‟s discussion of the above theological foundations of the common good plays a vital role in the formation of its application both at ecclesial and social levels: the common good of the church (commune ecclesiae bonum) is actualized when the gifts of the Spirit given to believers in union with Christ are shared mutually, in a way which reflects the restoration of God‟s image in believers - through prayer, sacrament, office, and property through the third use of the Law. The common good of humankind (publicum generis humani bonum) is actualized when the common grace given to humanity is exchanged and shared mutually through politics, economics, and social welfare, through the interplay between the third and second use of the Law. This thesis concludes that, although the ecclesial and social common good are cooperative in a distinctive but inseparable way, the former takes priority over the latter for the current and consummative restoration of the original order both at divine and moral levels.
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Naphy, William G. « Calvin and the consolidation of the Genevan Reformation ». Thesis, University of St Andrews, 1993. http://hdl.handle.net/10023/13605.
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This study is concerned with the process involved in Calvin's consolidation of his power in Geneva and his success in implementing his vision of a Reformed society and structure in the city. The principal aim is to re-evaluate all of the relevant data and to correct, where necessary, the present understanding of this process. This has involved detailed research in the primary, unpublished documentation held in the Genevan State Archives. This material has then been compared with the traditional interpretation of Genevan history which is derived largely from Calvin and his supporters. In an attempt to discover the true reasons which explain Calvin's triumph, particular attention has been focussed on the various groups in Geneva at the time. Thus, detailed examination has been made of the relevant documents to identify the various social, economic, and political links which bound together the opposing factions. In particular, the research in this study has examined the impact which the French religious refugees had on every aspect of Calvin's struggle in Geneva. In addition, the direct effect which the predominantly French pastors had on the city, through their ministerial and political activities, has been detailed. Special emphasis has also been laid upon the personal relationships which existed among Geneva's ruling élite. The results of this study show that the interpretation of Calvin's triumph in Geneva is, in fact, based too heavily on Calvin's own view of the events and personalities involved. Calvin's opponents are shown to be men determined to maintain their magisterial power in the city in the face of the threat posed by the French ministers and their refugee compatriots. The local Genevans who supported Calvin have been found to be men who profited, both personally and politically, from Calvin's defeat of his opponents. Therefore, the study presents a thorough re-examination of Calvin's Genevan ministry and demonstrates the motives and methods which produced Calvin's victory in the mid-1550s.
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Shin, Jung Woo. « God hidden and revealed in Luther and Calvin ». Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/30753.
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The main purpose of my thesis is a comparative study of the theme ‘God hidden and revealed’ in Luther and Calvin, with a focus on the relation between the hidden God and the revealed God. One of the serious issues debated in theological scholarship is the relation between the hidden God and revealed God. Some say the relation is antithetical, arguing from the apparently dualistic and irreconcilable aspects such as the arbitrariness of God and God as love. Some say that it is identical, seeing that in a single event of revelation, the eye of faith discerns the Deus revelatus, where sense-perception can only find Deus absconditus. While there have been many diverse critical views surrounding the issue of Luther’s God hidden and revealed, not much attention has been given to Calvin’s doctrine of hiddenness of God. Nor has a comparison been made of the relation between the hidden God and revealed God in Luther and Calvin. In this thesis, Luther’s concept of the hidden God is put on the matrix of his central theme of theology of the Cross, a theme which runs through his whole theology. Luther’s hidden God in the theology of the Cross is characterized as the God wearing the mask, who works abscondita sub contrariis in relation to his creature. Compared to Luther, however, this thesis shows that the concept of Deus absconditus is not only as native to Calvin’s theology as it is to Luther’s, but also parallels Luther’s in large parts. If the mask is the trademark of Luther’s hidden God, the idea of ‘accommodation’ can be Calvin’s trademark. The accommodating God speaks to us like a mother babbles to her child, in baby talk. As Luther’s God hides himself in masks to reveal himself, Calvin’s God accommodates himself to our human weakness and sinfulness to reveal himself. Luther’s ideas are deeply rooted in paradox. Much more so than Calvin, Luther describes so sheer and serious a contradiction between God hidden and revealed as to threaten the unity of God hidden and revealed. At the same time, Luther never loses his strong view of unity of God. ‘Unity in contradiction’ in God hidden and revealed can be understood only in Divine paradox, which tells us that contradiction is just in the human eye, not in God’s eye.
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Morehead, Daniel R. « Auricular confession in the theology of John Calvin ». Online full text .pdf document, available to Fuller patrons only, 2002. http://www.tren.com.
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Mein, Chong Eng. « The teaching of John Calvin on church discipline ». Theological Research Exchange Network (TREN), 1985. http://www.tren.com.
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Bell, M. Charles. « Calvin and Scottish theology : the doctrine of assurance / ». Edinburgh : Handsel press, 1985. http://catalogue.bnf.fr/ark:/12148/cb34936679g.
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Lange, van Ravenswaay J. Marius J. « Augustinus totus noster : das Augustinverständnis bei Johannes Calvin / ». Göttingen : Vandenhoeck & ; Ruprecht, 1986. http://catalogue.bnf.fr/ark:/12148/cb355621107.
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Garcia, Adelson Luiz. « A contribuição do pensamento social de João Calvino para a formação do cidadão ». Universidade Presbiteriana Mackenzie, 2015. http://tede.mackenzie.br/jspui/handle/tede/2466.
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Previous issue date: 2015-08-12Igreja Presbiteriana do Brasil
It deals of a work that finds to show the contribution of the social thought of John Calvin to the formation of the citizen. Thinking about this topic, we study that in the end of the Middle Age there was a great migration of the population to the cities. Before it a well-known picture was of the peasant and now it goes by to be the picture of the townsman. Naturally this transformation there would be to change the focus of the communal life and consequently the life in society. It increases the intensity of the social ties and thereafter more social problems. The society in transformation will need solid and balanced structure to develop and maintain itself through the laws and citizens that will regulate these laws. During the Middle Age, there was little assistance to the small existing society. With the Renaissance and the Religious Reform of the Sixteenth Century new contours of social and assistance thoughts go by to be applied in the society in this time. In this yeast of social transformation arises the picture of the reformer John Calvin, that, grounded in the Bible Scriptures of Ancient and New Testament, brought to the society of his age, over his thoughts and ideas, new directions to the citizen and his army of citizenship. John Calvin, in spite of not to be a sociologist, and to be a theologian person, brought social ideas of living together and citizenship through of his works and of the example-model too, that was left in the city of Geneva, where he could apply all of his concepts related to the society. Therefore, aspect such as: politic-administrative, educational and assistance were punctual and outstanding in help that John Calvin gave to the government of the city of Geneva. His performance was so special that many others inhabitants from other regions of Europe came to Geneva to learn his model and they will take to his lands. The processes that involve the study of citizen and the exercise of citizenship are always discussed, since the society lives in constant transformations. However, the citizen must prioritize principles that must be applied in any kind of transformation that the society may have. The citizen is involved intrinsically with the society. He is an integral part of its. Thus, he needs of high level formation that takes to be a contribute agent of the society, aiming to the common good of the same. The citizen must act in the society to participate so good of his government, practicing justice, how as governed, obeying the laws and serving to the Magistrates and Governments. John Calvin took his teachings to the citizens for that they were good examples of the citizenship to the society.
Trata-se de um trabalho que procura mostrar a contribuição do pensamento social de João Calvino para a formação do cidadão. Ao valer-nos deste tema, estudamos que em fins da Idade Média houve uma grande migração da população para as cidades. Antes uma figura muito conhecida era do camponês e agora passa a ser a figura do citadino. Naturalmente que essa transformação haveria de mudar o foco da vida comunitária e consequentemente a vida em sociedade. Aumentam a intensidade dos laços sociais e consequentemente mais problemas sociais. A sociedade em transformação precisará de estrutura sólida e equilibrada para se desenvolver e se manter através de leis e cidadãos que irão regular essas leis. Durante a Idade Média, houve pouca assistência à pequena sociedade existente. Com o Renascimento e Reforma Religiosa do Século XVI novos contornos de pensamento social e assistência passaram a ser aplicados na sociedade de então. Nesse fermento de transformações sociais surge a figura do Reformador João Calvino, que, fundamentado nas Escrituras do Antigo e Novo Testamentos, trouxe para a sociedade de sua época, através de seus pensamentos e idéias, novos rumos para o cidadão e seu exercício da cidadania. João Calvino, embora não fora um sociólogo, e sim teólogo, trouxe idéias sociais de convivência e cidadania através de suas obras e também do modelo-exemplo, deixado na cidade de Genebra, onde pôde aplicar todos os seus conceitos relativos à sociedade. Assim, aspectos como: político-administrativo, educacional e assistencial foram pontuais e marcantes na ajuda que João Calvino deu para o governo da cidade de Genebra. Sua atuação foi tão especial que muitos outros habitantes de outras regiões da Europa vieram até Genebra para aprenderem seu modelo e levarem para as suas terras. Os processos que envolvem o estudo do cidadão e exercício da cidadania são sempre discutidos, uma vez que a sociedade vive em constantes transformações. No entanto, o cidadão deve priorizar princípios que possam ser aplicados em qualquer tipo de transformação que a sociedade possa ter. O cidadão está intrinsecamente envolvido com a sociedade. É parte integrante dela. Sendo assim, necessita de uma formação de alto nível que o leve a ser agente contributivo da sociedade, visando ao bem comum da mesma. O cidadão deve atuar na sociedade de forma a participar tão bem de seu governo, exercendo justiça, quanto como governado, obedecendo as leis e servindo aos magistrados e governos. João Calvino levou os seus ensinos aos cidadãos para que fossem bons exemplos de cidadania para a sociedade.
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Jung, Hong Joo. « Civil authority, magisterial and individual responsibility in John Calvin's political theology ». Theological Research Exchange Network (TREN), 1994. http://www.tren.com.
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Sutter, Franziska [Verfasser]. « Diagnosis of failure of passive transfer in dairy calves and procedures after calving to improve harvesting of high-quantity and high-quality colostrum / Franziska Sutter ». Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1236897501/34.
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Eraso, Pichot Abel. « Adaptive regulation of calcium excitability and energy metabolism by CREB-dependent transcription in astrocytes : study of the mechanisms governing astrocyte plasticity ». Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664170.
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Cada cop més evidencies suggereixen que els astròcits participen en les altes funcions cerebrals, controlant des de la transmissió sinàptica fins a les ones cerebrals globals i els processos d’aprenentatge i memòria. Diferents mecanismes han sigut proposats com a responsables d’aquests processos mediats per astròcits, entre ells, l’alliberació de gliotransmissors a partir de les senyals de calci així com la de lactat semblen els principals efectors. L’existència d’aquest control de les funcions cerebrals per part dels astròcits suggereix que aquestes cèl·lules poden regular les funcions cerebrals en resposta a experiència tan com les neurones, constituint el fenomen de plasticitat astrocitària. En neurones s’ha demostrat que el conegut factor de transcripció CREB, coordina les plasticitats sinàptica i intrínseca. El fet que, en astròcits, l’activació de CREB també està regulada per activitat cerebral, situa aquest factor de transcripció com a la diana ideal per promoure canvis dependents d’activitat en astròcits. En aquesta tesi hem analitzat l’efecte de l’activació de la transcripció depenent de CREB en astròcits, centrant-nos en l’excitabilitat del calci i en el metabolisme d’aquestes cèl·lules. Hem demostrat que l’activació de la transcripció depenent de CREB redueix les senyals citosòliques de calci a través del mitocondri a la vegada que augmenta l’alliberació de lactat, dos canvis que poden tenir impacte en la transmissió sinàptica. Una altra contribució important d’aquest estudi es l’anàlisi molecular dels mitocondris dels astròcits, que ha revelat que aquestes cèl·lules poden utilitzar metabòlits que no són glucosa, com ara àcids grassos, per respondre a les necessitats metabòliques energètiques. Els nostres resultats estableixen el CREB en astròcits con un eix de la plasticitat astrocitària i revelen la interacció entre la plasticitat i el metabolisme energètic en astròcits. Aquests descobriments constitueixen un avenç mecanístic i conceptual en el coneixement de la biologia dels astròcits i com aquestes cèl·lules poden controlar l’aprenentatge i la memòria.An increasing body of evidence suggests that astrocytes participate in higher-brain functions, controlling from synaptic transmission to global brain waves and learning and memory processes. Different mechanisms have been proposed to mediate these astrocyte-dependent processes, astrocytic lactate release and calcium-dependent gliotransmission being the main known effectors. The existence of control of brain functions by astrocytes suggests that astrocytes may shape brain functions in response to experience as much as neurons, thus constituting the phenomenon of astrocyte plasticity. In neurons, the transcription factor CREB is the best known coordinator of synaptic and intrinsic plasticity. The fact that, in astrocytes, CREB activation is also activity-dependent, positions CREB as an ideal target to promote plasticity-related changes in astrocytes, too. In this thesis, we have analyzed the effect of the activation of CREB-dependent transcription in astrocytes, specifically regarding calcium signals and metabolism. We have demonstrated that activation of CREB-dependent transcription reduces cytosolic calcium events via mitochondria and increases in lactate release, which may have impact on synaptic transmission. An important contribution of the study is the molecular analysis of astrocytic mitochondria, which has revealed that astrocytes may use fuels other than glucose such as fatty acids to meet basic energy metabolic demands. Taken together, our results establish astrocytic CREB as a hub in astrocyte-plasticity and shed light on the interplay between plasticity and energy metabolism in astrocytes; these findings constitute a conceptual and mechanistic advance in the knowledge of astrocytic biology and how these cells may control learning and memory.
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Mikkonen, Juha. « Luther and Calvin on Paul's Epistle to the Galatians : an analysis and comparison of substantial concepts in Luther's 1531/35 and Calvin's 1546/48 Commentaries on Galatians / ». Åbo (Finland) : Åbo Akademi University Press ; Åbo akademis förlag, 2007. http://www.loc.gov/catdir/toc/fy0710/2007413415.html.
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Halsey, Michael D. « Persuasive strategies as seen in selected sermons of Calvin Miller ». Theological Research Exchange Network (TREN), 2000. http://www.tren.com.
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Cardoso, Dario de Araujo. « A influência do Saltério de Genebra na solidificação da fé reformada ». Universidade Presbiteriana Mackenzie, 2011. http://tede.mackenzie.br/jspui/handle/tede/2382.
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Previous issue date: 2011-02-22Fundo Mackenzie de Pesquisa
This research has as its object the Calvin´s proposal to produce metrical psalms for liturgical singing of the Reformed Church, which culminated in making the Geneva Psalter. The goal is to show how the Geneva Psalter served as an instrument of expression and the spread of Reformed theology. Seeks to demonstrate how the singing of psalms was introduced into the devotional practice of the Christian Church and its state before the Reformation. Then comes the resumption of congregational singing by Luther and Calvin and the principles that led him to defend the singing of metrical psalms and other biblical texts. This proposal gave rise to the Geneva Psalter that became a hallmark of Reformed Protestantism and influenced in different ways to hymnody of the Reformed churches.
A presente pesquisa tem como seu objeto a proposta de Calvino de produzir salmos metrificados para o cântico litúrgico da igreja reformada e que culminou na confecção do Saltério de Genebra. O objetivo é demonstrar como o Saltério de Genebra serviu de instrumento de expressão e propagação da teologia reformada. Procura demonstrar como o cântico de salmos se inseriu na prática devocional da Igreja Cristã e seu estado antes da Reforma. Trata então da retomada do canto congregacional por Lutero e Calvino e os princípios que levaram-no a defender o cântico de salmos metrificados e outros textos bíblicos. Essa proposta deu origem ao Saltério de Genebra que se tornou uma marca do protestantismo reformado e influenciou de maneiras diversas a hinologia das igrejas reformadas.
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Sifoleli, Israel. « A leitura da Bíblia na perspectiva de João Calvino : uma introdução à hermenêutica calvinista a partir dos salmos de lamento ». Universidade Presbiteriana Mackenzie, 2007. http://tede.mackenzie.br/jspui/handle/tede/2473.
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Previous issue date: 2007-08-31In this work the author looks for to rescue the reading that Calvin made of the Psalms of lament. It has as intention to present an introduction to the Calvin s hermeneutics. It calls attention for the fact of that although the great contribution of Calvin, its hermeneutics still is, in many aspects, stranger in Brazil. The author makes an attempt to establish the influences on Calvin s thought that had contributed for his hermeneutics. It continues demonstrating the importance of the authority of the Bible for Calvin. After that he presents the main points of Calvin s hermeneutics and for a better understanding, he divides them in presuppositions, principles and approaches. In the last chapter the focus is in an analysis of Calvin s hermeneutics, having the modern study of Psalms as aid. Finally, it presents an attempt of dialogue between Calvin s hermeneutics and contemporary Brazilian Protestantism. This dialogue is presented in the form of some challenges.
Neste trabalho, o autor procura resgatar a leitura que Calvino fez dos Salmos de lamento. Ele tem como propósito apresentar uma introdução à hermenêutica de Calvino. Ele chama atenção para o fato de que apesar da grande contribuição de Calvino, sua hermenêutica ainda é, em muitos aspectos, desconhecida no Brasil. O autor faz uma tentativa de estabelecer as influências sobre o pensamento de Calvino que contribuíram para a sua hermenêutica. Ele prossegue demonstrando a importância da autoridade da Bíblia para Calvino, em seguida, apresenta os pontos principais da hermenêutica de Calvino e, para uma melhor compreensão, divide-os em pressupostos, princípios e enfoques. No último capítulo, se propõe a fazer uma análise da hermenêutica de Calvino de forma mais focada, tendo o estudo moderno dos Salmos como ajuda. Finalmente, ele apresenta uma tentativa de diálogo entre a hermenêutica de Calvino e o protestantismo brasileiro, diálogo este apresentado em forma de alguns desafios.
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Souza, Mauricio de Castro e. « O empréstimo a juros em João Calvino ». Universidade Presbiteriana Mackenzie, 2006. http://tede.mackenzie.br/jspui/handle/tede/2510.
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Previous issue date: 2006-12-05Fundo Mackenzie de Pesquisa
The practice on interest on lent is present in everyday life. The Bible dealt with this issue, and the matter was a subject treated in the Code of Hammurabi and in the Roman Law. The loan interest, in the Middle Ages, was important to promote development, trade, marine exploration trips, and even in the Crusades. The Christian Church simultaneously condemned the practice of usury, that is, the lent on interest. But sometimes it not only authorized the practice, the Church did also benefit from it. Calvin, although personally contrary to the practice of lent on interest, realized the impossibility of its abolition and showed himself in favor of the lent on interest. Nonetheless, he separated between the loan for consumption and the loan for production, to be used to promote development. In his understanding, the loan for production was fair because the borrower, working out the money, intends to obtain a superior amount than the money taken. However, conscious that the interest affects directly the cost of living, resulting negatively to the poor, Calvin restricts and systematizes the loan on interest to aim two targets: 1) Our actions must glorify God; 2) Our benefits must affect positively the surrounding community.
A prática do empréstimo a juros sempre esteve presente na vida das pessoas, visto que a Bíblia, o Código de Hamurabi e o Direito Romano já tratavam do assunto. O empréstimo a juros na Idade Média foi importante para promover o desenvolvimento, sendo utilizado no comércio, nas viagens marítimas, e até mesmo nas épocas das Cruzadas. A Igreja Cristã, ao mesmo tempo em que condenava a prática da usura, isto é, empréstimo a juros, por muitas vezes não só autorizou mas, também, usufruiu de ganhos adquiridos com juros. Calvino, apesar de contrário à prática do empréstimo a juros, mas por perceber que seria impossível aboli-lo, manifestou-se de certa forma favorável à temática em questão. Todavia, separou o empréstimo de consumo, do empréstimo de produção, o qual foi utilizado para promover o desenvolvimento. No entender de Calvino, o empréstimo de produção era justo, pois, o que empresta nesta linha de ganho, pretende ganhar outro tanto superior o valor emprestado. Mas, consciente que os juros afetam diretamente o custo de vida, e os menos favorecidos financeiramente serão os mais afligidos, restringe e sistematiza o empréstimo a juros, com a dupla finalidade: 1) que as nossas atitudes glorifiquem a Deus; 2) que devem beneficiar a comunidade em que vivemos.
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Ong, Meng-Chai. « John Calvin on providence : the Locus Classicus in context ». Thesis, King's College London (University of London), 2003. https://kclpure.kcl.ac.uk/portal/en/theses/john-calvin-on-providence--the-locus-classicus-in-context(1ff65682-501d-49ee-8dea-f2ea6e513130).html.
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Temming, Maria C. « Melvin Calvin : Nobel-Winning chemist and SETI scientist wannabe ». Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112626.
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Thesis: S.M. in Science Writing, Massachusetts Institute of Technology, Department of Comparative Media Studies/Writing, 2017.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 26-27).
Melvin Calvin spent more than a decade answering one longstanding question in biochemistry: how did plants use carbon dioxide to manufacture carbohydrates in photosynthesis? This research earned Calvin a Nobel Prize-an honor that catapulted him to international fame, secured him spots on presidential advisory committees, and got him plenty of textbook mentions. But even though Calvin's claim to fame was his work on photosynthesis, his longestrunning passion project was investigating the origins of life in the universe. Astrobiology efforts peppered his career, from theorizing about chemical evolution to inspecting meteorites and moon rocks to joining the Order of the Dolphin at the first Search for Extraterrestrial Intelligence (SETI) conference in 1961.
by Maria C. Temming.
S.M. in Science Writing
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Ra, Young Hwan. « The eschatological hermeneutics of John Calvin and Wolfhart Pannenberg ». Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615906.
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Park, Gon-Taik. « La problématique de la liberté dans l'oeuvre de Calvin ». Paris 4, 2006. http://www.theses.fr/2006PA040061.
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Notre recherche sur la problématique de la liberté chez Calvin selon sa vie permet de mieux comprendre, 1) la relation et l'évolution de la liberté civile et de la liberté chrétienne pour Calvin, à partir de son Commentaire du De clementia et son Institution ; 2) sa conception de la liberté en relation avec la notion de la Vérité, d'après les textes contre les nicodémites ; 3) sa conception de la liberté en rapport à la responsabilité, d'après les textes contre les Anabaptistes ou les libertins spirituels ; 4) sa notion de la liberté de conscience ou de la liberté religieuse dont l'homme ne peut jouir pratiquement que sous la législation de l'Etat, bien que la conscience soit un don de Dieu. Mais pour avoir une synthèse de la conception calvinienne de la liberté. Il est nécessaire d'examiner la dernière Institution où l'on peut élaborer un schéma de la liberté. Notre liberté — liberté chrétienne — est au carrefour de toutes les libertés verticlaes (libertés divine et humaine) et horizontales (libertés intérieure et extérieure). Ainsi, le concept calvinien de la liberté parait bien pondéré et apte à gouverner la vie spirituelle et la vie corporelle. Nous pouvons donc dire qu'à côté d'un Calvin moderne, il y a un Calvin introspectifThis research for the issue of the freedom of Calvin through his life permit to understand better, 1) the relation and the evolution of the civil freedom and of the christian freedom for Calvin, from his Commentary on De clementia and his Institutes ; 2) his conception of the freedom with relation to the notion of the Truth, according to his anti-nicodemite texts ; 3) his conception of the freedom in relation to the responsibility, according to his texts against the Anabaptists or the spirituals libertines ; 4) his notion of the freedom of conscience or of the religious freedom which man can enjoy practically only under the legislation of the State, although the conscience is a gift of God. But in order to synthesize Calvin's conception of the freedom. It is necessary to examine the definitive edition of the Institutes where one can make a diagram of the freedom. Our freedom — christian freedom — is located on the crossroad of all "vertical"(divine-human) and “horizontal"(interior-exterior) freedoms. Thus, Calvin's concept of the freedom appear well level-headed and capable of governing the spiritual life and the corporal life. One can say that besides "a modern Calvin", there is also "a introspective Calvin"
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Johnsson, Tomas. « Reformationen och kyrkorummet : Luther, Calvin och det gestaltade rummet ». Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175948.
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Kim, Choong-Hwan. « Abendmahlsverständnis und Abendmahlsfrömmigkeit bei Calvin und im koreanischen Presbyterianismus / ». Regensburg : Roderer Verl, 1997. http://catalogue.bnf.fr/ark:/12148/cb38883284n.
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Boudreaux, Keith. « Calvin and the Sermon on the Mount an investigation into his theological method / ». Theological Research Exchange Network (TREN), 1987. http://www.tren.com.
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Butin, Philip Walker. « Revelation, redemption and response : Calvin's trinitarian understanding of the divine-human relationship / ». New York ; Oxford : Oxford university press, 1995. http://catalogue.bnf.fr/ark:/12148/cb370325224.
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Yance, Chávez Tula del Carmen. « Estudio y caracterización de la nueva quinasa dependiente de calmodulina : CKK2 ». Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396284.
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La familia de CaM quinasas (CAMK por sus siglas en inglés) son una familia de quinasas, dependientes del complejo Ca2+/CaM importantes por su implicación en diferentes funciones como la transcripción de genes, la supervivencia/muerte celular (apoptosis), la organización del citoesqueleto, el aprendizaje y la memoria (Swulius & Waxham, 2008). Se ha demostrado la funcionalidad de esta familia de quinasas al expresar la CAMKII humana en Schizosaccharomyces pombe produciendo un arresto del ciclo celular. Tambien se ha descrito en S. pombe una quinasa a homologa a la CAMKI de mamíferos funcional, la cual necesita para su activación la unión del complejo Ca2+/CaM y la fosforilación por una quinasa upstream. Nuestro grupo encontró que la fosforilación de Cmk1 en respuesta a Ca2+ desaparece al mutar la CAMKK, ckk2 (Cisneros-Barroso et al., 2014). En este trabajo planteamos como primer objetivo determinar si la fosforilación de Cmk1 es debida a la actividad de la quinasa Ckk2 de manera directa. Encontramos que fosforila a Cmk1 in vivo e in vitro, como su homóloga en mamíferos la CAMKK2, estableciendo una cascada de las CAMK en S. pombe. Encontramos también que Ckk2 es una quinasa dependiente del complejo Ca2+/CaM constituyéndose como una CAMK propiamente dicha.
La viabilidad de un mutante nos puede indicar si el gen mutado esta implicado en la vía del estrés al que es sometido. Al evaluar el mutante Δckk2 encontramos que la deleción de ckk2 compromete la viabilidad celular frente agentes que modifican el citoesqueleto (tiabendazol, Latrunculina) y es resistente frente agentes que compromete la pared celular (calcofluor). Del mismo modo quisimos evaluar el mutante Δckk2 en condiciones de deprivación de nutrientes y encontramos que la deleción de ckk2 no afecta la viabilidad celular, a diferencia de Ssp1, otra CAMKK en S. pombe (Hanyu et al. 2009), sin embargo es importante para la citocinesis. Observamos un retraso en la citocinesis en condiciones de deprivación de glucosa reflejado en un aumento del índice de septación entre las 4 y 12 horas de deprivación, y en condiciones de deprivación de nitrógeno encontramos que el mutante Δckk2 presenta un alto índice de septación con respecto a la cepa salvaje (26% y 0% respectivamente); esto nos indicaría que Ckk2 probablemente esté implicada en algún proceso que dé lugar a la citocinesis.
Addicionalmente, encontramos que la expresión de ckk2 aumenta tanto en condiciones de deprivación de glucosa como de nitrógeno, y este aumento se ve reflejado a nivel proteico. La proteína aumenta especialmente a partir de las 12 horas en deprivación, y además se observa una modificación pos-traduccional correspondiente a una sumoilación. Del análisis de la secuencia encontramos una lisina la K202, consenso de sumoilación (Beauclair et al. 2015; Zhao et al. 2014) y que se encuentra conservada en las CAMKK2, la homóloga en mamíferos de esta K202 está descrita como una lisina de ubiquitinación (Kim et al. 2011). Nosotros hemos estudiado la ubiqüitinizacón de nuestra proteína mediante anticuerpos pero no parece ubiquitinada. Por otra parte, tampoco está descrito que la CAMKK de mamíferos se encuentre sumoilada en alguna condición. Las modificaciones por sumo pueden alterar la actividad de una proteína, su localización, y/o estabilidad. En algunos casos sumo y ubiquitina tienen roles opuestos, donde la sumoilación protege la proteína de degradación ocupando la misma lisina
para la ubiquitinación (Miteva et al. 2010). Es presumible pensar que en condiciones ricas de nutrientes Ckk2 sea diana de ubiquitina y se degrade, explicando los bajo niveles de la proteína en medio rico; y por el contrario en condiciones de deprivación de nutrientes, se favorezca su sumoilación para estabilizarla, en acorde con la acumulación de Ckk2 a lo largo del tiempo.CAMK´s are a family of Ca2+/CaM dependent kinases important for several cellular processes such as gene transcription, surveillance and cell death, cytoskeleton organization, learning and memory (Swulius & Waxham 2008). Functionality of this family of kinases has been demonstrated in fission yeast where expression of human CAMKII in Schizosaccharomyces pombe produced cell cycle arrest. Moreover, a mammalian CAMKI homolog has been described in S. pombe, Cmk1. Cmk1 is activated by binding to Ca2+/CaM complex and phosphorylation by an upstream kinase. Our group has observed that phosphorylation of Cmk1 in response to calcium stress is absent in deletion of the CaMKK, Ckk2. (Cisneros-Barroso et al. 2014). At the present work, we have defined that Ckk2 phosphorylates in vivo and in vitro Cmk1, like its mammalian counterpart CAMKK2; establishing a CAMK cascade in S. pombe. Besides, Ckk2 binds to Ca2+/CaM complex constituting a CaM kinase itself . Cell viability of mutants exposed to certain conditions, gives some clues about the function of the mutated gene. So we found that Δckk2 mutant was sensitive to cytoskeleton disrupting agents (thiabendazol, latrunculina) and resistant to a chemical that disrupt cell wall (calcofluor). On the other hand, we analyzed Δckk2 in starving conditions and found that ckk2 deletion doesn’t have impact on cell viability, but it’s important for cytokinesis. We observed a delayed in cytokinesis upon glucose starvation and a high septation index in nitrogen starvation. Furthermore, we find that Ckk2 expression is upregulated at both, upon nitrogen and glucose starvation, and a modification by sumo is also observed. The lysine 202 is a consensus sequence for sumoylation and is conserved between CAMKK homologs. However, in mammalian CAMKK2, the K202 is ubiquitinated (Kim et al. 2011). We have evaluated Ckk2 ubiquitination, using antibodies and Ckk2 is not ubiquitinated. It is reported that the same lysine could be a target for ubiquitine and sumo, where sumoylation protects proteins from degradation by ubiquitynation (Miteva et al. 2010). According to our results, its reasonable to think that in rich nutrient media Ckk2 is target for degradation, and when nutrient availability is limited Ckk2 is expressed and stabilized by sumo.
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Aquino, Martínez Rubén Francisco. « Cooperation of calcium, BMP and WNT signalling for optimal osteoblast differentiation. Application for bone tissue engineering ». Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399725.
Texte intégralRésumé :
At least two specific features differentiate bone from other tissues, a blend of organic and mineral components, and a cellular organization with a hierarchical commitment degree. During bone remodeling osteoclasts dissolve the mineral and degrade the organic bone components, releasing the degradation products to the extracellular space.
Bone is one of the hardest connective tissues in the human body. However, skeletal tissue can be injured by trauma, atrophied by tooth loss, destroyed by pathological conditions or incompletely formed during congenital craniofacial bone defects, such as cleft palate. Autogenous bone is considered the “gold standard” to regenerate bone defects. However, wherever bone is harvested undesirable and detrimental effects are produced at the donor area. To avoid these drawbacks, bone tissue engineering has emerged to provide an alternative to autogenous bone harvesting drawbacks.
It has been shown by several “in vitro” an “in vivo” studies that BMP-2 promotes osteogenic differentiation and bone formation. High doses are required (e.g. 1-45 mg/ml in animal models) to obtain acceptable outcomes. However, several side effects, such as inflammation and ectopic bone formation, have been reported after using elevated amounts of BMP-2.
In this work we employed a composite Gelatin/CaSO4 scaffold that allows for an early expansion of seeded MSC´s, which is followed by an increased level of osteogenic differentiation after 10 days in culture. Furthermore, this seeded scaffold enhanced bone formation in a mouse model of critical-size calvarial defects. More importantly, ex vivo pretreatment of MSC´s with low amounts of BMP-2 (2nM) and Wnt3a (50 ng/ml) for 24 hours cooperatively increases the expression of osteogenic markers in vitro and bone regeneration in the critical-size calvarial defect in the mouse model.
Moreover, we determined the molecular mechanisms involved in cooperation between Ca2+ and BMP-2 in MSC´s at early and late differentiating points. Early, at 24 hours, we observed an intracellular network activation which is antagonistic to BMP-2/Smad signalling. More importantly, a significant cooperative effect between Ca2+ and BMP-2 is observed after 10 days. Ca2+ promotes an autocrine/paracrine feed-forward loop that reinforces the BMP-2 osteogenic input. Of note, Ca2+ alone induced similar osteogenic effects as BMP-2 alone in long-term cell culture.
In conclusion, cytokine signalling (such as BMP-2) and signalling from the mineral component (such as Ca2+) signals interact during bone remodeling. Early on, Ca2+ inhibits BMP-2 differentiation effect but later amplifies and reinforces the osteogenic BMP-2 effect.Al menos dos características distinguen al hueso de otros tejidos, es una mezcla de elementos orgánicos y minerales y además tiene una organización celular con diferentes niveles de diferenciación. Durante el remodelado óseo los osteoclastos disuelven el componente mineral y degradan la fase orgánica liberando sus productos de degradación hacia el espacio extracelular. El tejido óseo puede ser dañado después de un trauma, puede sufrir atrofia por la pérdida de dientes, podría ser destruido por condiciones patológicas o incompletamente formado en pacientes que sufren paladar hendido. El injerto autólogo ha sido considerado la mejor alternativa para regenerar defectos óseos. Sin embargo, se produce una morbilidad en la zona donante. La ingeniería de tejidos óseos ha surgido como una alternativa al hueso autólogo. Ha sido demostrado por estudios in vitro e in vivo que BMP-2 favorece la diferenciación de osteoblastos. Altas dosis son necesarias para obtener resultados aceptables. Sin embargo, varios efectos adversos han sido reportados después de usar estas dosis elevadas. En este trabajo hemos utilizado una combinación de Gelatina/CaSO4 como andamiaje para cultivar células madre mesenquimales. Pretratamiento de MSC´s “ex vivo” con dosis bajas de BMP-2 (2nM) y Wnt3a (50 ng/ml) durante 24 horas incrementó cooperativamente la expresión de marcadores osteogénicos “in vitro” y la regeneración ósea en defectos de tamaño critico en cráneo de ratón. Además, determinamos el mecanismo molecular involucrado en la cooperación entre Ca2+ y BMP-2 a corto y largo término. Al inicio (24 horas), observamos la activación de una red de señalización intracelular antagónica a BMP-2/Smad. A los 10 días, un efecto cooperativo entre Ca2+ y BMP-2 es observado. Ca2+ promueve la secreción endógena de BMP-2 lo cual produce un efecto autocrino y paracrino que refuerza la acción inicial de BMP-2. Notablemente, un efecto similar en la diferenciación osteoblástica fue observado en MSC´s tratadas únicamente con Ca2+ comparado con las tratadas solo con BMP-2. En conclusión, BMP-2 y Ca2+ interactúan durante el remodelado óseo. Inicialmente, Ca2+ regula el estímulo de BMP-2 inhibiendo la diferenciación celular producida por BMP-2 pero después de 10 días amplifica y refuerza el efecto de BMP-2.
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Wainwright, Daniel. « Calving front dynamics : External forces that lead to specific sized calving events ». Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237686.
Texte intégralRésumé :
Currently there is no extended study that explicitly focuses on themagnitude, frequency and timing of glacial calving resulting from externalforces. Past studies have identified the size and timing of calving events butthe links between them and the external factors that cause them are stillmissing. Here I present a method to identify the size, time and frequency ofcalving events on the Rink Glacier in Greenland. Using time lapse imagesspaced 30 minutes apart of the calving front, coupled with weather and tidedata, I plan on identifying the main driving force for calving. Results showthat atmospheric pressure and temperature have no positive correlation withcalving magnitude or size. Tidal influences and sea surface temperatureappear to have the strongest influence on the frequency of calving. As seasurface temperatures rapidly decrease though the study period, calvingfrequency also reduces. Strong calving correlations for the entire studyperiod were difficult to identify for tidal influences, as images could only betaken during the sunlit periods of the day. As this study was conductedduring autumn when atmospheric temperatures remained below 0°C, theavailability of melt water for crevasse creation and basal lubrication was notpresent. Therefore it is suggested that future studies on glacial stabilityshould use external forces to measure ice loss over the entire calving season.
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Kim, Jeong Woo. « The relevance of Calvin's ethics to basic issues in contemporary virtue ethics ». Theological Research Exchange Network (TREN) Access this title online, 1992. http://www.tren.com.
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