Thèses sur le sujet « Calcium activated chlorine channels »
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Adair, Jeanette. « Alternate channel therapy for the pancreatic disease of Cystic Fibrosis ». Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251005.
Texte intégralSharma, Aarushi. « HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM ». OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1252.
Texte intégralBrookfield, Rebecca. « The pharmacology and cardiovascular function of TMEM16A channels ». Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-pharmacology-and-cardiovascular-function-of-tmem16a-channels(bdc16466-cecd-4343-9d40-b20bc647d70f).html.
Texte intégralGeorgiou, Panayiotis Paulou. « Calcium-activated potassium-channels in mammalian eggs ». Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/29774.
Texte intégralFarrington, Jasmine. « Calcium release activated calcium channels in human lung mast cells ». Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6609/.
Texte intégralConrad, Rachel [Verfasser]. « Trafficking of voltage-activated calcium channels / Rachel Conrad ». Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1136717919/34.
Texte intégralMillership, Joanne Ella. « Regulation and function of calcium-activated potassium channels ». Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503016.
Texte intégralMarsey, Laura Louise. « Molecular and functional investigations of the calcium activated chloride channel in cystic fibrosis pancreatic duct cells ». Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445193.
Texte intégralHagen, Brian M. « Regulation of calcium-activated potassium channels by localized calcium transients in murine colon ». abstract and full text PDF (free order & ; download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209955.
Texte intégralD'hoedt, Dieter. « Structure-function analyses of small-conductance, calcium-activated potassium channels ». Diss., [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00006036.
Texte intégralLippiat, Jonathan David. « Molecular properties of recombinant large conductance calcium-activated potassium channels ». Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29928.
Texte intégralDeng, Zhihui. « SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS ». Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.
Texte intégralBohm, Rudy Ashish. « Transcriptional control of slowpoke, a calcium activated potassium channel gene / ». Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004218.
Texte intégralMacdonald, Stephen Hsiao-Feng. « Alternative splicing of large-conductance calcium- and voltage-activated potassium (BK) channels ». Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29237.
Texte intégralDoorty, Kevina Bridget. « Identification of novel toxin inhibitors of apamin-sensitive calcium-activated potassium channels ». Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286597.
Texte intégralMcCartney, Claire Elizabeth. « Effect of hypoxia on neuronal large conductance calcium-activated potassium (BKca) channels ». Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410156.
Texte intégralClarke, Alison L. « Mechanism of Fatty Acid Modulation of Calcium-Activated Potassium Channel Activity ». eScholarship@UMMS, 1997. http://escholarship.umassmed.edu/gsbs_diss/277.
Texte intégralMatias, Madeleine Gundayao. « Animal calcium release-activated calcium (CRAC) channels are homologous and derived from the ubiquitous Cation Diffusion Facilitators ». Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1453033.
Texte intégralTitle from first page of PDF file (viewed June 25, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 48-51).
Inglis, Victoria. « The effect of ã-dendrotoxin on calcium-activated potassium channels in neuroblastoma cells ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0008/MQ60131.pdf.
Texte intégralJoshi, Atul. « A possible link between calmodulin and calcium-activated potassium channels in bovine chromaffin cells / ». Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55663.
Texte intégralBahia, Parmvir Kaur. « A study of small and intermediate conductance calcium-activated potassium channels in sensory neurones ». Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445301/.
Texte intégralChu, Benson. « Alcohol Modulation of N-methyl-D-aspartate Gated Receptor/Channels and Large Conductance Calcium-Activated Potassium Channels : a Dissertation ». eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/164.
Texte intégralPetrik, David. « The role of the ß4 subunit in phosphorylation of calcium-activated potassum [sic] channels a dissertation / ». San Antonio : UTHSC, 2008. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1588771871&sid=3&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Texte intégralSane, Mukta. « Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries ». Diss., North Dakota State University, 2016. http://hdl.handle.net/10365/25665.
Texte intégralSaqar, Wedad Ali. « Characterization of Small Conductance Calcium-Activated Potassium Channels in a Human Lens Epithelium Cell Line (B3) ». Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1401279427.
Texte intégralKrishnamoorthy, Gayathri. « MECHANISM OF CALCIUM DEPENDENT GATING OF BKCa CHANNELS : RELATING PROTEIN STRUCTURE TO FUNCTION ». online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1144444855.
Texte intégralMurphy, Matthew M. « Investigating the Effects of CyPPA on Small-Conductance Calcium-Activated Potassium Channels in SOD1G93A Transgenic Mouse Model ». Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1589929963490428.
Texte intégralRo, Seungil. « SK channels : distribution, function and regulation in mouse colonic myocytes / ». abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.
Texte intégralKye, Min-Jeong. « Regulation of small-conductance, calcium-activated potassium channels (SK) in mouse brain in response to aging and stress ». [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/kye/kye.pdf.
Texte intégralHuston, Elaine. « Involvement of voltage activated calcium channels in neurotransmitter release and its modulation in cultured rat cerebellar granule neurones ». Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283291.
Texte intégralTjong, Yung-wui. « Mechanisms of attenuated large conductance calcium-activated potassium channel activity in rat hippocampal CA1 pyramidal neurons in chronic intermittent hypoxia ». Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793953.
Texte intégralHermann, David [Verfasser], et Andreas [Akademischer Betreuer] Draguhn. « Effects of Abeta Oligomers and State-Dependent Channel Blockers on High Voltage-Activated Calcium Channels / David Hermann ; Betreuer : Andreas Draguhn ». Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177148390/34.
Texte intégralHillman, David James. « Membrane currents evoked by vasoactive compounds in vascular endothelial cells : contributions of small and intermediate conductance calcium-activated potassium channels ». Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445578/.
Texte intégralShah, Yousef. « Effects of point mutations on the block of SK3 small-conductance calcium-activated potassium channels expressed in mammalian cell lines ». Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446491/.
Texte intégralHolland, Michael. « A patch clamp study of pharmacological and physiological regulators of large conductance calcium-activated potassium channels in arterial smooth muscle cells ». Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29937.
Texte intégralBraxton, Joi Requan. « Effect of preload on the response of mouse trachea smooth muscle to cholinergic stimulation a thesis / ». San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=33&CISOBOX=1&REC=10.
Texte intégralDegen, Rudolf [Verfasser], Marc [Akademischer Betreuer] Spehr et Ivan [Akademischer Betreuer] Manzini. « Identification and physiological characterization of calcium-activated ion channels in vomeronasal sensory neurons of the mouse / Rudolf Degen ; Marc Spehr, Ivan Manzini ». Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1238693865/34.
Texte intégralTharp, Darla L. « Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation ». Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5936.
Texte intégralThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2007" Includes bibliographical references.
Apolinar, Sanrda. « BK channel involvement in beta-adrenergic relaxation of murine tracheal smooth muscle a thesis / ». San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=32&CISOBOX=1&REC=3.
Texte intégralWynne, Patricia M. « Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels : A Dissertation ». eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.
Texte intégralFeinberg-Zadek, Paula Leslie. « Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance : A Dissertation ». eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/195.
Texte intégralAssadian, Sarah. « Rodent FDG-PET imaging for the pre-clinical assessment of novel glioma therapies ». Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101836.
Texte intégralLa découverte accélérée de nouvelles molécules thérapeutiques qui ciblent lesmécanismes de progression du cancer tels que l'invasion et l'angiogenèse, nécessite lamise au point et la validation de techniques efficaces qui permettent d'évaluer l'efficacitéthérapeutique de ces agents in vivo. Le développement récent des scanners detomographie à émission de positron (TEP) dédiés à l'imagerie de petits animaux(microPET, CT! Concorde R4), permet aujourd'hui d'obtenir une image fonctionnelle etmoléculaire de haute résolution des modèles rongeurs. Cette étude s'intéresse au potentieldu 18F-2-fluoro-2-deoxyglucose (FDG) en utilisant l'imagerie microPET dansl'évaluation de l'efficacité de nouveaux agents thérapeutiques dans un modèle de gliomechez le. rat. Cette technique pourrait éventuellement mener à une évaluation rapide et àgrande échelle de la réponse tumorale, ainsi que la mesure de l'efficacité d'agentsthérapeutiques in vivo au stade d'étude préclinique. Globalement, cette étude a pour butde faciliter la transition entre la découverte de nouvelles molécules thérapeutiques et leursapplications cliniques.
Waiczies, Sonia. « Modulation of human antigen-specific T-cell response therapeutic implications for multiple sclerosis / ». Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969681844.
Texte intégralHerr, Julia Emily. « Mechanisms of Rupture of Mucin Vesicles from the Slime of Pacific Hagfish (Eptatretus stoutii) : Roles of Inorganic Ions and Aquaporin Water Channels ». Thesis, 2012. http://hdl.handle.net/10214/3687.
Texte intégralNSERC Discovery Grant, NSERC CGSM scholarship, Canada Foundation for Innovation, Ontario Ministry of Research and Innovation
Leverköhne, Ina [Verfasser]. « The novel CLCA gene family of multifunctional calcium-activated chloride channels : genetic, structural and expression studies in the murine model system / by Ina Leverköhne ». 2003. http://d-nb.info/969346182/34.
Texte intégralGao, Yadong [Verfasser]. « The role of calcium-activated potassium channels and store-operated calcium channels in human macrophages / vorgelegt von Yadong Gao ». 2007. http://d-nb.info/986359440/34.
Texte intégralD'hoedt, Dieter [Verfasser]. « Structure-function analyses of small-conductance, calcium-activated potassium channels / Dieter D'hoedt ». 2005. http://d-nb.info/982304323/34.
Texte intégral« Functional expression of sperm Ca²⁽-activated K⁽ channels in xenopus oocytes and their modulations by Ca²⁽-evoking agonists ». 2000. http://library.cuhk.edu.hk/record=b6073247.
Texte intégral"September 2000."
Thesis (Ph.D.)--Chinese University of Hong Kong, 2000.
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Mode of access: World Wide Web.
Abstracts in English and Chinese.
Wang, Ya-Jean, et 王雅貞. « Stimulatory Effects of the Estrogen-Receptor Modulators on Large-Conductance Calcium-Activated Potassium Channels ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/13761727049091187819.
Texte intégral國立成功大學
基礎醫學研究所
96
The large conductance Ca2+-activated K+ (BKCa) channels, which are formed by ��-subunit tetramers, are encoded by a nearly ubiquitous, alternatively spliced gene, SLO (KCNMA1). Activation of the channel is under dual control, i.e., allosterically switched on either by membrane depolarization or by increased [Ca2+]i. Recent studies demonstrated that in addition to their binding to estrogen receptors, the modulators of estrogen receptors (ERs) may have direct effects on the activity of these channels in a non-genomic pathway. In these studies, a series of compounds known to bind to ERs were investigated concerning their possible effects on ion currents. First, diosgenin (3��-hydroxy-5-spirostene), originally extracted from the root of wild yam (Dioscorea villosa), was reported to antagonize the binding of estradiol to ERs. The results of this study provide the evidence that it can activate BKCa channels in HCN-1A neuronal cells through increased [Ca2+]i. Second, resveratrol (trans-3,4',5-trihydroxystilbene) is a common phytoalexin that was found in some edible materials, including grape skins, peanuts, and red wine. Several lines of evidence suggest that resveratrol may exert protective effects on the cardiovascular system. Our results also demonstrated that this compound can directly stimulate the activity of BKCa channel in human cardiac fibroblasts (HCFs). It is likely that the observed increase in activity of BKCa channels by resveratrol is due to its stimulation of the probability of channel openings which occurred in rapid open-close transitions. However, no modification in single-channel conductance of BKCa channels was found. Third, PPT (4,4′,4′′-(4-propyl-[1H]-pyrazole-1,3,5-triyl) tris-phenol) and DPN (2,3-bis(4-hydroxyphenyl)-propionitrile) were ER agonists selective for ER-�� and ER-β, respectively. PPT or DPN applied to the intracellular face of the membrane enhanced the activity of BKCa channels with no change in single-channel conductance. PPT- and DPN-stimulated increase in BKCa channels revealed novel pharmacological properties attributable to the activity of these channels, and their direct increase in BKCa-channels activity may contribute to cellular function. Finally, the theoretical simulations were used to predict effection of action potential duration by alterations in the BKCa channel conductance. The increase of BKCa channel conductance may reduce cardiac action potential duration. Resveratrol (or DPN) induced stimulation of BKCa channels may regulate cardiac action potential. Prolongation of action potential in electrically coupled cardiomyocytes can be reversed by increase of BKCa channel activity. Taken together, the regulation by ER modulators of BKCa-channel activity in a variety of cells can be due to a mechanism unlinked to their binding to ERs. These modulators of the channels may provide a therapeutic potential in neurological disorders and cardiovascular disease.
« High voltage activated calcium channels in pancreatic beta-cells : Possible role in glucose desensitization ». Tulane University, 2005.
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