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Littérature scientifique sur le sujet « C812 »

Auteur : Grafiati
Publié le 26 juillet 2024

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Articles de revues sur le sujet "C812"

1

Baxter, Brady. « Management of chronic iron overload ». Paediatric Care 14, no 7 (septembre 2002) : 14–16. http://dx.doi.org/10.7748/paed2002.09.14.7.14.c812.

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Brodsky, J. L. « Insulin activation of brain Na(+)-K(+)-ATPase is mediated by alpha 2-form of enzyme ». American Journal of Physiology-Cell Physiology 258, no 5 (1 mai 1990) : C812—C817. http://dx.doi.org/10.1152/ajpcell.1990.258.5.c812.

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The sensitivity of the synaptosomal Na(+)-K(+)-ATPase to insulin was examined and found to be stimulated by the hormone when physiological intracellular sodium concentrations were present. Activation was not mediated by a sodium influx into the vesicles, as shown using sodium uptake experiments and by the fact that tetrodotoxin did not inhibit insulin action. Because the brain Na(+)-K(+)-ATPase catalytic subunit exists as two forms with different affinities for the inhibitory cardiac glycoside ouabain, the sensitivity of each form for insulin was examined. As previously observed in adipocytes, only the high-affinity component, alpha 2, was insulin sensitive. A dose-response curve of insulin activation of the Na(+)-K(+)-ATPase demonstrated a maximal insulin effect at relatively high hormone concentrations. It is unknown, therefore, whether stimulation of the brain Na(+)-K(+)-ATPase occurs in vivo.
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Janigro, D., G. A. West, E. L. Gordon et H. R. Winn. « ATP-sensitive K+ channels in rat aorta and brain microvascular endothelial cells ». American Journal of Physiology-Cell Physiology 265, no 3 (1 septembre 1993) : C812—C821. http://dx.doi.org/10.1152/ajpcell.1993.265.3.c812.

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The endothelium plays an important role in the modulation of vascular tone and blood cell activation. Extensive work has demonstrated that the release of endothelium-derived relaxing factor (EDRF) from the endothelium is evoked by a number of physical and chemical stimuli requiring Ca2+. Because endothelial cells do not express voltage-dependent Ca2+ channels, Ca2+ influxes following receptor activation may be facilitated by cell hyperpolarizations mediated by the activation of K+ conductances. There has been recent interest in the role of ATP-sensitive K+ channels (KATP) suggesting that KATP may play a role in the regulation of blood flow. We have investigated the electrophysiological properties of an ATP-sensitive K+ conductance in whole cell and membrane patches from rat aorta and brain microvascular endothelial cells. Whole cell as well as single-channel currents were increased by either intracellular dialysis of ATP or application of glucose-free/NaCN (2 mM) solutions. Both currents were reversibly blocked by glibenclamide (1-100 microM). The KATP channel opener pinacidil (30 microM) caused activation of an outward current in the presence of physiological intracellular ATP concentrations. In inside-out patches, 10 microM-1 mM ATP invariably caused a dramatic decrease in channel activity. We conclude that both rat aorta and brain microvascular endothelial cells express KATP channels. KATP may play a role in the regulation of endothelial cell resting potential during impaired energy supply and therefore modulate EDRF release and thus cerebral blood flow.
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Valenti, G., J. M. Verbavatz, I. Sabolic, D. A. Ausiello, A. S. Verkman et D. Brown. « A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells ». American Journal of Physiology-Cell Physiology 267, no 3 (1 septembre 1994) : C812—C820. http://dx.doi.org/10.1152/ajpcell.1994.267.3.c812.

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The water channel CHIP28 accounts for the high water permeability of proximal tubules and thin descending limbs of Henle; a homologous water channel, WCH-CD, in the apical membrane of collecting duct principal cells, may be the vasopressin-sensitive water channel. We show here that one antiserum, raised against CHIP28, immunostains the basolateral membrane of collecting duct principal cells, in addition to staining CHIP28 in other cells. This serum was named anti-basolateral integral protein (anti-BLIP) to distinguish it from other anti-CHIP28 antisera. By Western blotting, BLIP serum recognized both CHIP28 and MIP26, and it stained lens fibers, which contain MIP26 but not CHIP28. BLIP antiserum immunoprecipitated a 28-kDa band, a broad 35- to 50-kDa band, and an approximately 16-kDa band from kidney papilla. It also stained the basolateral membrane of gastric parietal cells, which were not stained with anti-CHIP28 or anti-MIP26 antibodies. BLIP antiserum immunoprecipitated a 28-kDa protein band from stomach; this protein was not precipitated by anti-CHIP28 antibodies. These results suggest that basolateral membranes of principal cells and parietal cells contain a protein(s) that shares common epitopes with CHIP28 and MIP26. Finally, BLIP but not CHIP28 antiserum stained mesothelial (but not epithelial) cells of toad urinary bladder, a further indication that the BLIP antiserum recognizes a protein distinct from CHIP28.
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Hattori, M., K. Sakamoto, N. Fujihara et I. Kojima. « Nitric oxide : a modulator for the epidermal growth factor receptor expression in developing ovarian granulosa cells ». American Journal of Physiology-Cell Physiology 270, no 3 (1 mars 1996) : C812—C818. http://dx.doi.org/10.1152/ajpcell.1996.270.3.c812.

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the present study was designed to assess the involvement of nitric oxide (NO) in the regulation of the epidermal growth factor (EGF) receptor during development of rat granulosa cells, which were prepared by puncturing ovaries of diethylstilbestrol-treated rats. The immature cells were cultured for 48 h with follicle-stimulating hormone (FSH) to be transformed into mature cells. A marked accumulation of guanosine 3',5' -cyclic monophosphate (cGMP) was observed during development. The accumulation of cGMP, but not of adenosine 3',5'-cyclic monophosphate (cAMP), was suppressed by specific inhibitors of NO synthase, L-NG-monomethyl-L-arginine (L-NMMA) and L-N(G)-nitro-L-arginine, and a selective inhibitor of the inducible NO synthase, aminoguanidine. The L-NMMA-induced suppression was partially reversed by addition of L-arginine to cultures but not D-arginine, indicating that NO formation is inhibited by competing with analogues of L-arginine for NO synthase. Treatment with 2-(4-carboxyphenyl)-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide , an antagonist of NO, caused suppression in the increase of EGF binding sites, whereas exposure of the cells to sodium nitroprusside (SNP), an NO donor, caused elevation in EGF binding sites, with increasing extra- and intracellular cGMP levels. Analysis of the EGF receptor by affinity labeling with 125I-labeled EGF revealed that the intensity of the cross-linked receptor molecular with a molecular mass of 180 kDa was increased by exposure to SNP. The facilitatory effect of SNP on the EGF receptor was observed when the cAMP-dependent pathway was fully activated by FSH. However, the NO effect may be mediated by a cGMP-independent pathway, as 8-bromo-cGMP did not mimic the action of SNP. These results indicate that the L-arginine-NO system may contribute to the regulation of EGF receptor expression in developing granulosa cells stimulated by FSH.
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Fischer, Silvia, Matthias Clauss, Marion Wiesnet, Dieter Renz, Wolfgang Schaper et Gerhard F. Karliczek. « Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO ». American Journal of Physiology-Cell Physiology 276, no 4 (1 avril 1999) : C812—C820. http://dx.doi.org/10.1152/ajpcell.1999.276.4.c812.

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In this study, an in vitro model of the blood-brain barrier, consisting of porcine brain-derived microvascular endothelial cells (BMEC), was used to evaluate the mechanism of hypoxia-induced hyperpermeability. We show that hypoxia-induced permeability in BMEC was completely abolished by a neutralizing antibody to vascular endothelial growth factor (VEGF). In contrast, under normoxic conditions, addition of VEGF up to 100 ng/ml did not alter monolayer barrier function. Treatment with either hypoxia or VEGF under normoxic conditions induced a twofold increase in VEGF binding sites and VEGF receptor 1 (Flt-1) mRNA expression in BMEC. Hypoxia-induced permeability also was prevented by the nitric oxide (NO) synthase inhibitor NG-monomethyl-l-arginine, suggesting that NO is involved in hypoxia-induced permeability changes, which was confirmed by measurements of the cGMP level. During normoxia, treatment with VEGF (5 ng/ml) increased permeability as well as cGMP content in the presence of several antioxidants. These results suggest that hypoxia-induced permeability in vitro is mediated by the VEGF/VEGF receptor system in an autocrine manner and is essentially dependent on reducing conditions stabilizing the second messenger NO as the mediator of changes in barrier function of BMEC.
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da Costa, Maria, Sheldon P. Rothenberg, Easwara Sadasivan, Annette Regec et Lian Qian. « Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules ». American Journal of Physiology-Cell Physiology 278, no 4 (1 avril 2000) : C812—C821. http://dx.doi.org/10.1152/ajpcell.2000.278.4.c812.

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A folate-binding protein (FBP) anchored to cell membranes by a glycosyl phosphatidylinositol (GPI) adduct is constitutively expressed in some transformed and cultured cell lines. Its expression is upregulated when these cells are grown in medium containing low folate, but whether this occurs in vivo with nutritional folate deficiency is unknown. To address this question, the GPI-FBP in the liver, kidney, and brain of rats on control and folate-deficient (FD) diets was measured. The GPI-FBP in the kidney of FD rats decreased significantly in contrast to the upregulation of this protein in cultured cells. Northern blot analysis and nuclear run-on assays indicated that transcription of the GPI-FBP gene in the kidney was not reduced by folate deficiency. This decrease of the GPI-FBP appears to result from its proteolysis, similar to the enzymatic degradation of the apoprotein that occurs in vitro. Because the GPI-FBP is on the brush borders of the proximal renal tubules and provides for the reabsorption of folate, this function diminishes when the protein decreases in folate deficiency.
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Vasquez Chavez, Jule Franve, Arturo Zapata, Juan Luis Garcia, Carlos Barrionuevo, Edgar Diaz, Ebert Poquioma, Tatiana Vidaurre et Luis Malpica. « Incidence and survival of Hodgkin lymphoma patients treated at a national cancer center in a middle-income country from 1999-2018 : A report of 1,382 cases. » Journal of Clinical Oncology 39, no 15_suppl (20 mai 2021) : e19523-e19523. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19523.

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e19523 Background: Hodgkin lymphoma (HL) is classically described as a malignancy with a good prognosis and bimodal pattern. We aim to describe the incidence and survival of HL patients treated at the National Cancer Institute (NCI) in Peru. Methods: We evaluated the database at the NCI Epidemiology Department in Peru from 1999-2018. The international classification of diseases (ICD)-10 codes C810-C813, C817, C819 and ICD for Oncology (version 3) codes 96503-96533, 96573-96593, 96533-96553, 96573, 99903 were used to classify both nodal and extra-nodal HL. The estimate of overall survival (OS) curves was performed by the Kaplan-Meier method, and the difference was computed by the log-rank test. Results: During the study period 12,092 patients with lymphoma were found, of which 1,382 (11.4%) were HL. The median age was 24 years (range 2-88). Male patients were 62.4%. Patients of ≤14 years were 32.9%, with the most frequent 5-year interval group those aged 5-9 years-old representing 16.7% of patients. The adolescent and young adults (AYA) (15-39 years) group represented 38.4%. A total of 1,360 (98.4%) were classified as nodal HL. The classification according to the subtypes was as follows: 1,148 (83.1%) were one of the five subtypes [classical HL (cHL) and nodular lymphocyte-predominant HL (NLPHL)], 196 (14.2%) were HL, not otherwise specified, and 38 (2.7%) were HL without pathological confirmation. The classifiable 1,148 patients were categorized as follows: 1,107 patients (96.4%) were cHL and 41 (3.6%) were NLPHL. The cHL patients were classified as mixed cellularity HL (MCHL) in 52.3%, nodular sclerosis HL (NSHL) in 36.7%, lymphocyte-rich HL (LRHL) in 8.1%, and lymphocyte-depleted HL (LDHL) in 2.9%. The whole classifiable cohort (n = 1,148) showed a trimodal pattern. The MCHL subtype was most frequent in the 5-9 years group and in the 60-64 years group. The NSHL subtype was most frequent in the 20-24 years group. The median 5-year OS of the entire cohort (n = 1,382) was 86.3% (95%CI, 83.9-88.5). The OS according to the interval age groups were as follows: for the 0-14 years group the 5-yr OS was 94.9% (95%CI, 91.8-96.8), for the 15-39 years was 84% (95%CI, 79.5-87.68), for the 40-64 years group was 82.5% (95%CI, 75.2-87.8), and for the ≥65 years group was 58.6% (95%CI, 43.4-71.1). The OS according to age range showed a statistically significant difference p < 0.01. Conclusions: In our study, patients with HL are younger compared to those in developed countries. The most frequent 5-year interval group is the 5-9 years group. HL incidence had a trimodal pattern. Extra-nodal presentation was extremely rare. NLPHL was also rare. The most frequent subtype was MCHL, however, in AYA patients the most frequent subtype was NSHL. Better OS was seen in the 0-14 year group, this being statistically significant compared to the older groups. Worse OS was observed in patients aged 65 and older.
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Ashenfelter, Orley. « Comparing Real Wage Rates ». American Economic Review 102, no 2 (1 avril 2012) : 617–42. http://dx.doi.org/10.1257/aer.102.2.617.

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A real wage rate is a nominal wage rate divided by the price of a good and is a transparent measure of how much of the good an hour of work buys. It provides an important indicator of the living standards of workers, and also of the productivity of workers. In this paper I set out the conceptual basis for such measures, provide some historical examples, and then provide my own preliminary analysis of a decade long project designed to measure the wages of workers doing the same job in over 60 countries—workers at McDonald's restaurants. The results demonstrate that the wage rates of workers using the same skills and doing the same jobs differ by as much as 10 to 1, and that these gaps declined over the period 2000–2007, but with much less progress since the Great Recession. (JEL C81, C82, D24, J31, N30, O57)
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Demir, Semahat S., John W. Clark et Wayne R. Giles. « Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart : a unifying model ». American Journal of Physiology-Heart and Circulatory Physiology 276, no 6 (1 juin 1999) : H2221—H2244. http://dx.doi.org/10.1152/ajpheart.1999.276.6.h2221.

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We have extended our compartmental model [ Am. J. Physiol. 266 ( Cell Physiol. 35): C832–C852, 1994] of the single rabbit sinoatrial node (SAN) cell so that it can simulate cellular responses to bath applications of ACh and isoprenaline as well as the effects of neuronally released ACh. The model employs three different types of muscarinic receptors to explain the variety of responses observed in mammalian cardiac pacemaking cells subjected to vagal stimulation. The response of greatest interest is the ACh-sensitive change in cycle length that is not accompanied by a change in action potential duration or repolarization or hyperpolarization of the maximum diastolic potential. In this case, an ACh-sensitive K+ current is not involved. Membrane hyperpolarization occurs in response to much higher levels of vagal stimulation, and this response is also mimicked by the model. Here, an ACh-sensitive K+ current is involved. The well-known phase-resetting response of the SAN cell to single and periodically applied vagal bursts of impulses is also simulated in the presence and absence of the β-agonist isoprenaline. Finally, the responses of the SAN cell to longer continuous trains of periodic vagal stimulation are simulated, and this can result in the complete cessation of pacemaking. Therefore, this model is 1) applicable over the full range of intensity and pattern of vagal input and 2) can offer biophysically based explanations for many of the phenomena associated with the autonomic control of cardiac pacemaking.
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Thèses sur le sujet "C812"

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Howard, David John. « Psychological, social and emotional changes experienced by student nurses undertaking the Project 2000 system of training ». Thesis, Nottingham Trent University, 1999. http://eprints.lincoln.ac.uk/7343/.

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The research reported in this thesis examined the changes that students undertaking the Project 2000 (UKCC, 1986) course in nursing experience. It was carried out in one school of nursing in the Midlands over a period of 3 years and the various stages of empirical enquiry involved a total of 218 questionnaires, 10 interviews and 30 stress studies. A phenomenological methodology was adopted which incorporated a 3 stage mixed method approach. During the initial 2 stages complementary data were collected from two cohorts of students (cohort 1 n=40, cohort 2 n=19) to explore their experiences of the course and identify significant issues. To identify possible changes in their methods of studying the Revised Approaches to Studying Inventory (Tait & Entwistle, 1996) was used. Insight into other changes that occurred during the course was afforded by supplementing these data with demographic data and qualitative data obtained from interviews. Two main themes arose; Changes in Approaches to Studying and Psychological Distress. In the final stage of this research each theme was considered using quantitative methods. Two instruments were developed and data was obtained from 2 samples of students (n=76, n=30). These were analysed using descriptive and inferential statistical tests and the results compared with those from earlier stages of this research and the literature. Linking the findings of this research to other enquiries also suggests that these students are typical of all Project 2000 students at this time (Yin, 1994; Bassey, 1998). Therefore, this research contends that Project 2000 students are likely; in terms of approaches to studying: (a) to change their approach to studying from a Surface Approach in favour of a Deep Approach as they see the relevance of the theory to the practice of nursing; (b) to exhibit the pattern which is common in higher education that older students tend towards a Deep Approach to studying; in terms of confidence and ability in studying: (c) by the end of the first year of the course to show no difference in confidence or ability in studying which can be attributed to their academic qualifications on entry to the course; in terms of psychological distress: (d) to experience various intensities of distress during the course associated with: • the theory component of the course (due to perceptions of irrelevance of the “health” model taught, particularly during the CFP); • loss of control (concerning the administration of the course and also the adverse group pressure exerted by the Adult Branch students in the CFP); • clinical practice (due to perceptions of not being prepared for the “curative-illness” model during the CFP, a lack of clinical skills, and sometimes due to hostility from placement staff); • assignments (due to lack of co-ordination between the different modules and clinical experiences, and related problems of time-management); • financial pressures (often resulting in additional employment to supplement bursaries); and; in terms of personal development and personal relationships: (e) to become more self-aware, assertive and non-judgemental in professional settings; (f) to have a high chance of personal difficulties with spouses or partners, particularly those students between the ages of 25-34 years.
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Hernon-Jarvis, Jane. « The role of emotions in initial teacher training in English further education ». Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/28655/.

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This thesis examines the emerging role of emotional labour in the context of Further Education (FE) colleges in England. These colleges provide Initial Teacher Training (ITT) courses of study for Further Education teachers who are training to become qualified practitioners in the English lifelong learning sector. Using four teacher trainees and four teacher trainers, the thesis explores the nature and scope of how emotional labour can impact on teacher trainees’ learning and the well-being of both teacher trainees and teacher trainers in order to investigate how the insights gleaned would help to develop practice in the field of English ITT in English FE. The findings evidenced that when teaching, a relationship can form. This can be a professional relationship or a relationship that exceeds the boundaries of professionalism. Over a six-month period in 2013/2014 the teacher trainee participants completed an autobiographical life-grid, whilst both trainees and trainers completed a diary and end interview. An exploratory study using two FE colleges and analysis of data using thematic analysis was used to explore the role of emotions in ITT in FE colleges. Two significant findings presented themselves within this thesis. Firstly, the emotional dimensions of a) FE teaching are explored, and b) it is recommended that the support that is given for new teachers in FE in England become an explicit part of the curricula and of staff development in ITT delivery. Secondly, in supporting teaching staff to alleviate the burden of emotional labour, social sharing (i.e. talking about emotional aspects with peers, colleagues) should be encouraged.
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Kerner, Charlotte Lynn. « Relationships between body image, motivation and physical education (PE) experiences in 13-14 year old boys and girls ». Thesis, University of Bedfordshire, 2013. http://hdl.handle.net/10547/315360.

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Research has established that body image disturbance is associated with a number of negative physical and psychological health outcomes. It is recognised that body image is subject to situational variability, yet to date, research seems to have overlooked the explicit exploration of the stability of the construct within physical education. With this in mind the overarching aim of this thesis was to explore relationships between body image, perceptions of competence and motivation, with specific attention paid to the influence of the physical education environment upon year nine boys and girls situational body satisfaction. Secondly, the thesis explores the role that these three psycho-social constructs play in transfer of learning. The design of the research was a correlational, repeated measures study conducted across two time points, combined with focus group sessions. Quantitative data collection at time point one consisted of 620 pupils from 37 year 9 physical education classes. Time point two consisted of 461 pupils from 38 physical education classes. At both quantitative time points students responded to a questionnaire package which explored perceptions of competence towards physical education, motivation for physical education and aspects of trait and state body image. Participants at time point one also provided demographic information. Additionally, 159 pupils at time point one underwent anthropometric assessments of body fat and BMI. The findings from the thesis identify that 71%-80% of year 9 boys and girls are dissatisfied with their current body size. It was identified that the majority of variance in situational body satisfaction within physical education can be attributed to factors operating at the pupil and time level, with a smaller yet significant proportion of variance being attributed to between-class factors. Lesson content did not significantly predict variations in body satisfaction scores within physical education and evidence from the focus group sessions suggest that classroom entry factors such as the changing rooms maybe more influential that factors operating within the lesson itself. Results revealed higher levels of body satisfaction within physical education are associated with higher perceptions of competence within physical education, higher levels of autonomous towards physical education, higher transfer of learning scores and lower amotivation towards physical education scores. Collectively, the results of the thesis identify the prevalence of body dissatisfaction in 13-14 year old boys and girls and the potential implications negative body satisfaction can have for experiences of physical education. Findings of the thesis warrant further investigation of how the psychological variables explored relate to further contextual and pedagogical factors.
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Bliss, Carly May. « Immune responses to vaccines against malaria ». Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:98c507b1-c812-4857-9ca8-4beaa57e1c35.

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The development of a malaria vaccine is necessary for disease eradication. Successful vaccine candidates to date have targeted the asymptomatic, pre-erythrocytic stage of the disease, however even the most efficacious vaccines are only partially protective. Research undertaken in our laboratory has demonstrated that one such regimen, using an 8 week prime-boost viral vector approach of ChAd63 ME-TRAP and MVA ME-TRAP, induces sterile efficacy in 21% of vaccinees, with a key role identified for TRAP-specific CD8+ T cells. The work described in this thesis explores the most immunogenic regimen by which to administer these two pre-erythrocytic malaria vaccines. A shortening of the prime-boost interval from 8 to 4 weeks, and the addition of an extra ChAd63 ME-TRAP priming vaccination, both demonstrated improved T cell immunogenicity over the standard 8 week regimen. Further to this, novel assays were developed to aid the evaluation of vaccine-induced immune responses. Adaptations of the existing methodology for ELISpot analysis and to whole blood flow cytometry techniques, enabled more detailed analyses of paediatric vaccine-induced T cell responses in The Gambia. This work also permitted the comparison of vaccine immunogenicity in this paediatric population, with malaria-naïve and malaria-exposed adult vaccinees. The results suggest that vaccine-induced T cell responses in infants of 8 weeks and older are comparable to that of adults. A second approach involved the development of a novel functional assay. This assay quantitatively measured the in vitro inhibition of intrahepatic Plasmodium parasite development using T cells from ChAd63.MVA ME-TRAP vaccinated volunteers. The assay demonstrated the ability of CD8+ T cells to inhibit parasite development in a TRAP-specific manner, and provides a platform with which to further explore pre-erythrocytic immune responses.
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Chow, K. « Simulation and analysis of gas freeing of oil tanks ». Thesis, Coventry University, 2010. http://curve.coventry.ac.uk/open/items/692c76ab-c812-3ea9-29fe-0fe6cab4e469/1.

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This thesis presents an in-depth study of the gas freeing of marine crude oil tanks using numerical simulation, beginning with a general summary of the problem, followed by an outline of the objectives of this work and the main difficulties involved. To outline essential background, a review of numerical methods, fluid flow, and related physical mechanisms has been undertaken, in addition to related ventilation fields, jet and jet impingement, and tanker-borne ventilation, in order to determine the state of the art and draw useful parallels between different ventilative fields, as well as identifying potential areas for model validation. A room-ventilation test case was studied in order to demonstrate the numerical method. It was found that assuming adiabatic walls and ignoring radiation resulted in highly idealised temperature predictions, and that radiation played a large part in enhancing vertical temperature prediction by redistributing thermal energy. For the gas-freeing analysis, the geometric models and solution procedures are introduced before simulation results presented and validated with analytical jet models and impingement penetration parameters. Analysis showed that the internal temperature of the tank was approximately homogeneous, allowing the tank to be considered isothermal. 2D simulations showed that after an initial period of time, the relative concentration distribution reaches steady state with decreasing average concentration as gas-freeing continues. Discussion of the results followed, examining aspects surrounding heat transfer and the choice of turbulence model, analysing the differences in the results between the first and secondmoment closure schemes and justification of assuming isothermal conditions. The variation in concentration was examined, and an analytical expression was derived which approximates the reduction in average gas concentration decay due to gas-freeing. It has been shown that double-hulled construction renders the internal temperature variation to around 10% of the temperature difference between the sea and deck. During the gasfreeing process proper, it was shown that after any stratified layer has been eroded and a stable flow field established, the relative concentration distribution remains constant. Gas freeing times were shown to be heavily dependent on the volume flux (and thus air change rate), and mathematical relations derived in order to provide approximately predict the time to gas free a crude oil tank (COT) given particular initial conditions.
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Haag, Markus. « Personal knowledge development in online learning environments : a personal value perspective ». Thesis, University of Bedfordshire, 2010. http://hdl.handle.net/10547/134937.

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This thesis investigates personal knowledge development in online learning environments and the impact that personal values have on it. Personal knowledge development was investigated from the perspective of Nonaka’s SECI model of organisational knowledge creation. This model served as the basis for an adapted model that conceptualises personal knowledge development in online learning at the individual level. The personal value types of the Schwartz Value Survey and the Portrait Values Questionnaire were adopted to measure personal values and their impact on personal knowledge development in online learning environments. Three data collection approaches were used. First, an exploratory study was conducted which elicited online learners’ experiences of their personal knowledge development in online learning; this study used online discussion forums for data collection. Second, a Delphi study was carried out. Experts were asked which of the ten individual-level value types by Schwartz are likely to be particularly relevant in the context of online learning. Third, an online survey was created. Its aim was to measure the impact that personal values and background variables, such as gender and age, have on personal knowledge development in online learning. A measurement instrument was devised that measures three of the SECI modes, namely Externalisation, Combination and Internalisation. This instrument measures the magnitude of online learners’ Externalisation and Combination activities as well as their level of Internalisation, i.e. the outcomes of personal knowledge development. Results of the exploratory study show that there are widely diverging experiences of personal knowledge development in online learning. The literature review suggests that the cultural situatedness of an online learning environment is an important influencing factor on personal knowledge development. The results of the Delphi study suggest that Self-Direction, Stimulation, and Achievement are particularly relevant value types in the context investigated here. Finally, the online survey confirms this view, as all three value types were found to be positively correlated with Externalisation, Combination, and Internalisation, with the exception of the Achievement-Combination relationship. A modified version of the SECI model is proposed, which extends the applicability of the original SECI model from the organisational to the individual level. It is argued that this model is suitable to describe personal knowledge development in the context of online learning. The study also contributes to closing the gap in research on the impact of personal values in the context investigated in this study. Moreover, a measurement instrument was created that can be used to measure Externalisation and Combination, i.e. personal knowledge development processes, and Internalisation, i.e. personal knowledge development outcomes.
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Kuegel, Christina. « Creating a functional play framework for children with autism and severe learning difficulties ». Thesis, University of Bedfordshire, 2017. http://hdl.handle.net/10547/622700.

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Play is an important contributor to children’s development: it reflects, reinforces, and results in development (Johnson, Christie, Wardle, 2005). However, the tools available to support planning and measurement of play are not sufficiently detailed or focused on children with autism and severe learning difficulties (SLD). Play for children with autism is consistently identified as restrictive and repetitive. Although extensive research examines symbolic play, the content and structure of functional play, which is considered a valuable precursor of symbolic play, is rarely the subject of focused research (Williams, 2003; Lifter, Foster-Sanda, Arzamarski, Briesch, & McClure, 2011). Given the developmental potential that play presents, the aim of this study was to examine the functional play presented by children with autism and SLD, with a view to designing a play framework that enables teachers to support functional play development in the classroom. A pragmatic mixed methods approach was adopted across a three-stage study in three schools. Study 1 provides the background for creating a functional play framework, while Study 2 focuses on the creation of the framework through objective observations of the play activity of a total of 27 children with autism and SLD, as well as interviews with nine classroom teachers. Study 3 was a process of trialling the framework in two schools and collaborating with eight teachers to finalise the functional play framework, in particular by considering its usability. Data collected across the three studies provided a description of functional play that suggests it is more complex than traditionally defined. Four key areas of functional play were identified: interacting with one object; interacting with two (or more) objects; interacting with self; and interacting with the environment. Additionally, 12 subcategories were established as components related to functional play. Teachers reported that they could use the framework to baseline play, set targets and measure play progression for children with autism and SLD. The framework was also identified as a tool that supports classroom management and continuing professional development. The proposed framework facilitates the identification of small increments of progress and extends on other available play frameworks. By developing detailed descriptions of the play that children with autism and SLD present, the framework provides a greater ability to identify precise deficits and, more specifically, to target support in the area of play. Additionally, the collaborative approach with classroom teachers provides diverse viewpoints but also begins to merge the gap between researchers and practitioners in order to ensure a useful resource. Recommendations for further descriptive accounts, greater involvement of classroom professionals in the development of resources and additional trials of the framework are acknowledged.
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Martin, Florian, Vera Hemmelmayr et Tina Wakolbinger. « Integrated service selection, pricing and fullfillment planning for express parcel carriers - Enriching service network design with customer choice and endogenous delivery time restrictions ». WU Vienna University of Economics and Business, 2019. http://epub.wu.ac.at/6986/1/SSPFP.pdf.

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Express parcel carriers offer a wide range of guaranteed delivery times in order to separate customers who value quick delivery from those that are less time but more price sensitive. Such segmentation, however, adds a whole new layer of complexity to the task of optimizing the logistics operations. While many sophisticated models have been developed to assist network planners in minimizing costs, few approaches account for the interplay between service pricing, customer decisions and the associated restrictions in the distribution process. This paper attempts to fill this research gap by introducing a heuristic solution approach that simultaneously determines the ideal set of services, the associated pricing and the fulfillment plan in order to maximize profit. By integrating revenue management techniques into vehicle routing and eet planning, we derive a new type of formulation called service selection, pricing and fulfillment problem (SSPFP). It combines a multi-product pricing problem with a cycle-based service network design formulation. In order derive good-quality solutions for realistically-sized instances we use an asynchronous parallel genetic algorithm and follow the intuition that small changes to prices and customer assignments cause minor changes in the distribution process. We thus base every new solution on the most similar already evaluated fulfillment plan. This adapted initial solution is then iteratively improved by a newly-developed route-pattern exchange heuristic. The performance of the developed algorithm is demonstrated on a number of randomly created test instances and is compared to the solutions of a commercial MIP-solver.
Series: Schriftenreihe des Instituts für Transportwirtschaft und Logistik - Supply Chain Management
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Robertson, Welsh Bradley. « On the influence of nozzle geometries on supersonic curved wall jets ». Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/on-the-influence-of-nozzle-geometries-on-supersonic-curved-wall-jets(bc8817e4-c812-44bc-8dfb-f5d0fdf62a72).html.

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Circulation control involves tangentially blowing air around a rounded trailing edge in order to augment the lift of a wing. The advantages of this technique over conventional mechanical controls are reduced maintenance and lower observability. Despite the technology first being proposed in the 1960s and well-studied since, circulation control is not in widespread use today. This is largely due to the high mass flow requirements. Increasing the jet velocity increases both the efficiency (in terms of mass flow) and effectiveness. However, as the jet velocity exceeds the speed of sound, shock structures form which cause the jet to separate. Recent developments in the field of fluidic thrust vectoring (FTV) have shown that an asymmetrical convergent-divergent nozzle capable of producing an irrotational vortex (IV) has the potential to prevent separation through eliminating stream-wise pressure gradients. In this study, the feasibility of preventing separation at arbitrarily high jet velocities through the use of asymmetrical nozzle geometries designed to maintain irrotational (and stream-wise pressure gradient free) flow is explored. Furthermore, the usefulness of an adaptive nozzle geometry for the purpose of extending circulation control device efficiency and effectiveness is defined. Through a series of experiments, the flow physics of supersonic curved wall jets is characterised across a range of nozzle geometries. IV and equivalent area ratio symmetrical convergent-divergent nozzles are compared across three slot height to radius ratios (H/R): H/R = 0.1, H/R = 0.15, H/R = 0.2. The conclusion of this study is that at low H/R (0.1 and 0.15), there is no significant difference in behaviour between IV and symmetrical nozzles, whilst at high H/R (0.2), the IV nozzles begin separating whilst correctly expanded due to the propagation of pressure upstream from the edge of the reaction surface via the boundary layer. Consequently, it is shown that symmetrical nozzles of equivalent mass flow at high H/R have a higher separation NPR compared to IV nozzles. Specifically, the elimination of favourable, in addition to adverse stream-wise pressure gradients contradicts the expected behaviour of IV nozzles. The separation NPR for nozzles tested in this study, in addition to past studies is subsequently plotted against the throat height to radius ratios (A*/R). This shows that in fact, no previous experiments have shown a higher separation NPR for IV nozzles compared to symmetrical nozzles of equivalent mass flow. The overall outcome is that neither fixed geometry IV, nor adaptive nozzles are justified to maintain attachment, or to improve efficiency. This is because fixed nozzle geometries designed for higher separation NPR do not show any performance deficit when operating at lower NPRs. However, the throat height could be varied to maximise effectiveness (at the expense of mass flow). The contributions to new knowledge made by this study are as follows: the development of a new method of combining shadowgraph and schlieren images to simplify and enhance visualisation of supersonic flows; the use of pressure sensitive paint (PSP) to study the structure of the supersonic curved wall jet before and after separation; the identification of a clear mechanism for the separation of supersonic curved wall jets, valid over a broad range of nozzle geometries (including a clarification of previously unexplained behaviour witnessed in prior studies); the explanation that reattachment hysteresis occurs due to the upstream movement of the point of local separation at full separation (specifically, this explains why certain geometries such as backward-facing steps prevent reattachment hysteresis).
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McIvor, Stephen. « Mentally tough teams in professional Rugby Union : important factors, processes and mechanisms ». Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/25464/.

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The aim of this research is to further enhance our understanding of the construct mental toughness in professional rugby union teams. While mental toughness is synonymous with sporting success, considerable ambiguity exists concerning what it actually is, how it is developed and, most pertinently in the demanding environment of professional rugby, how it can be elicited on a game-to-game basis. To achieve these aims, an initial semi-structured interview-based study with nine elite players and three elite coaches explored their understanding of mental toughness. The results highlight that mental toughness involves player-specific processes and coaching processes along with an emphasis upon group processes. Building on these results, a second interview-based study was conducted with five super-elite coaches. The results from this cohort reaffirm the importance of group identity in consistently eliciting mental toughness. The results highlight the integral role that the coach plays in challenging group standards and in fostering togetherness and respect. Moreover, the results identify processes that coaches may utilise in developing, integrating and harnessing mentally tough leaders, the alignment of formal leaders and, crucially, how coaches communicate mentally tough messages to their players via the media. In conclusion, in order to elicit mental toughness in rugby union the coach needs to manage the multiple messages within the team environment that enhances group identity and the motivation to act mentally tough. In this regard, in order to elicit mental toughness in a rugby team on a consistent basis, it is essential that the coach is aware of, and manages, individual processes, coaching processes and, most importantly, the wider environment and social milieu. This requires coaches to create an aligned leadership and to manage the multiple messages that players receive, including those from the media, in order to create a mentally tough mindset.
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Livres sur le sujet "C812"

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Antunes, António Lobo. Os cus de Judas. Lisboa : Dom Quixote, 1986.

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Antunes, António Lobo. Le cul de Judas. Paris : Christian Bourgois, 2006.

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C, Ornstein Allan, Behar-Horenstein Linda S et Pajak Edward 1947-, dir. Contemporary issues in curriculum. 3e éd. Boston : Allyn and Bacon, 2003.

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International Congress of Prehistoric and Protohistoric Sciences (15th 2006 Lisbon, Portugal). Methods of art history tested against prehistory : Session C74. Spiral and circular forms : the most common rock art in the world ? : session C81. European cave art : session C85. Euro-Mediterranean rock art studies : session S02. Global state of the art : session S07. Current state of North American rock art : session WS37. Oxford : Archaeopress, 2010.

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Khan, Shamus Rahman. Privilege : The making of an adolescent elite at St. Paul's School. Princeton : Princeton University Press, 2011.

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Notes, Just. Booklets - Books - Notes : Music Manuscript Paper, 5-Line Staves, with Simple Clean Design. Cover Pink Squares C81. Independently Published, 2020.

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Hefte, Just. Hefte - Blöcke - Notizen : Vokabelheft DIN A4, 50 Seiten, Soft Cover, Inhaltsverzeichnis, 2 Spalten, Erfolgs-Tracker, Ideal Zum Lernen C81. Independently Published, 2020.

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Booklets - Books - Notes : Music Manuscript Paper, 5-Line Staves, with Simple Clean Design. Cover Black and White Squares 3d C82. Independently Published, 2020.

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Infinite Citizen of the Shaking Tent. McClelland & Stewart, 2015.

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Mrs. Spring Fragrance : Large Print. Independently Published, 2021.

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Chapitres de livres sur le sujet "C812"

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Vogt, J. « 683 C8H2 1,2,3,4,5,6,7-Octaheptaenylidene ». Dans Asymmetric Top Molecules. Part 3, 186. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-14145-4_105.

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Kumar, M., et R. Gupta. « Magnetic susceptibility exaltation data of C8H12 ». Dans Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds, 211. Berlin, Heidelberg : Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-44736-8_143.

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Kumar, M., et R. Gupta. « Magnetic susceptibility exaltation data of C8H12 ». Dans Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds, 212. Berlin, Heidelberg : Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-44736-8_144.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1623. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1587.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1624. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1588.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1625. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1589.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1626. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1590.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1627. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1591.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1628. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1592.

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Kalinowski, H. O., M. Kumar, V. Gupta et R. Gupta. « Nuclear magnetic resonance data of C8H12 ». Dans Chemical Shifts and Coupling Constants for Carbon-13, 1629. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-45285-0_1593.

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Actes de conférences sur le sujet "C812"

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Xu, Shu-mei, et Yuan-shuo Yang. « The design of the real-time acquisition system of temperature and humidity based on ADμC812 ». Dans 2011 International Conference on Electrical and Control Engineering (ICECE). IEEE, 2011. http://dx.doi.org/10.1109/iceceng.2011.6057578.

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Rahmer, J. « ESR Investigations on 13C enriched Sc3@C82 ». Dans STRUCTURAL AND ELECTRONIC PROPERTIES OF MOLECULAR NANOSTRUCTURES : XVI International Winterschool on Electronic Properties of Novel Materials. AIP, 2002. http://dx.doi.org/10.1063/1.1514065.

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Grobis, M. « Spatially Dependent Inelastic Tunneling in Gd@C82 ». Dans ELECTRONIC PROPERTIES OF NOVEL NANOSTRUCTURES : XIX International Winterschool/Euroconference on Electronic Properties of Novel Materials. AIP, 2005. http://dx.doi.org/10.1063/1.2103809.

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Weiß, M., et S. J. Rupitsch. « C8.2 - Simulation-based Homogenization and Characterization Approach for Piezoelectric Actuators ». Dans AMA Conferences 2017. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2017. http://dx.doi.org/10.5162/sensor2017/c8.2.

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Vanselow, C., B. Espenhahn, D. Stöbener, A. Fischer, L. Schumski et D. Meyer. « C8.2 Near Process Coolant Flow Field Measurements in a Grinding Machine ». Dans SMSI 2021. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2021. http://dx.doi.org/10.5162/smsi2021/c8.2.

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Bizzarri, A., M. Cajlakovic, M. Suppan et V. Ribitsch. « C8.2 - Optochemical Sensor Intrumentation for Continuous Monitoring of Abdominal Oxygen Tension by Microdialysis ». Dans SENSOR+TEST Conferences 2011. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2011. http://dx.doi.org/10.5162/sensor11/c8.2.

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Maier, F., St Dierneder, G. Weidenholzer et A. Berger. « C8.2 - An Electro-Dynamic Energy Harvester Supplying a Wireless Sensor Node ». Dans AMA Conferences 2013. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2013. http://dx.doi.org/10.5162/sensor2013/c8.2.

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Fleßner, M., M. Blauhöfer, E. Helmecke, T. Hausotte et A. Staude. « C8.2 - CT measurements of microparts : Numerical uncertainty determination and structural resolution ». Dans AMA Conferences 2015. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2015. http://dx.doi.org/10.5162/sensor2015/c8.2.

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Marciu, D., C. Figura, S. Wang, J. R. Heflin, P. Burbank, S. Stevenson et H. C. Dorn. « Enhanced Degenerate Four-Wave Mixing in an Endohedral Metallofullerene Through Metal-to-Cage Charge-Transfer ». Dans Organic Thin Films for Photonic Applications. Washington, D.C. : Optica Publishing Group, 1997. http://dx.doi.org/10.1364/otfa.1997.the.15.

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Since the initial discovery and development of a technique for macroscopic preparation of the archetypal and most abundant fullerene C60, a wealth of fullerene-based structures have been produced including higher fullerenes, charge-transfer complexes, fullerene derivatives, superconducting exohedral-doped fullerenes, and carbon nanotubes. One of the most intriguing fullerene classes is the endohedral fullerene in which the spheroidal molecular structure is employed to encapsulate a small number of atoms (one to four) internal to the cage.1,2 Until recently, the difficult separation process of endohedral fullerenes had limited their availability to submilligram levels. Consequently, initial studies of these materials had primarily been restricted to electron paramagnetic resonance (EPR) and linear spectroscopy. EPR measurements demonstrated that, for the case of La@C82, the La atom transfers three electrons to the fullerene cage and resides in the +3 oxidation state.2 Metal-to-cage charge transfer appears to be a common feature of transition metal-containing endohedral metallofullerenes. Meanwhile, nonlinear optical studies of empty-cage C60 and C70 have shown that these materials possess both large third order susceptibilities χ(3)(−ω4;ω1,ω2,ω3)3 (~10-11 esu) and strong optical limiting behavior.4,5 We report here the first nonlinear optical measurements of an endohedral metallofullerene and find a dramatic enhancement in the third order nonlinear optical response. Degenerate four-wave mixing (DFWM) experiments on solutions of the endohedral metallofullerene Er2@C82 show that the metal-to-cage charge transfer provides a mechanism for increasing χ(3)(−ω4;ω1,ω2,ω3) by orders of magnitude relative to empty-cage fullerenes.
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Kerr, William G., Robert Brooks, Mi-Young Park, Matthew Gumbleton, Sonia Iyer, Dennis Viernes, John Chisholm et Gwenny Manel Fuhler. « Abstract C81 : Therapeutic potential of SHIP1 and SHIP2 inhibitors in cancer. » Dans Abstracts : AACR-NCI-EORTC International Conference : Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011 ; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-c81.

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Rapports d'organisations sur le sujet "C812"

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Barber, E. The effects on vapor pressure and heat of vaporization of adding the liquid coolant C816 to the evaporative coolant R-114. Office of Scientific and Technical Information (OSTI), août 1988. http://dx.doi.org/10.2172/7007244.

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