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Littérature scientifique sur le sujet « C07X »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "C07X"

SZEIMIES, R., et M. LANDTHALER. « C070 Photodynamic therapy ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S73. http://dx.doi.org/10.1016/s0926-9959(97)89142-8.

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HOLZLE, E. « C078 Photopatch testing ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S75. http://dx.doi.org/10.1016/s0926-9959(97)89152-0.

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ROELANDTS, R. « C077 Investigation of photodermatoses ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S75. http://dx.doi.org/10.1016/s0926-9959(97)89154-4.

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DELEO, V. « C075 Drug-induced photosensitivity ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S74. http://dx.doi.org/10.1016/s0926-9959(97)90098-2.

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BEANI, J. « C076 Photoprovocation of idiopathic photodermatoses ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S74—S75. http://dx.doi.org/10.1016/s0926-9959(97)89150-7.

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WULF, H. « C079 Assessment of skin type ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S75. http://dx.doi.org/10.1016/s0926-9959(97)89151-9.

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KRUTMANN, J. « C073 Indications for UVA 1 phototherapy ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S74. http://dx.doi.org/10.1016/s0926-9959(97)89146-5.

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THOMAS, P. « C072 PUVA, how to do it safely ? » Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S74. http://dx.doi.org/10.1016/s0926-9959(97)89148-9.

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Rodrigues, Ayane Araújo, Tereza Cristina de Carvalho Souza Garcês, André dos Santos Carvalho, Maria Isabel de Vasconcelos Mavignier Neta, Even Herlany Pereira Alves, Thayaná Ribeiro Silva Fernandes, Jacks Renan Neves Fernandes et al. « Scientific and technological prospection of Pilocarpus microphyllus and epiisopilothurin related to their anti-inflammatory activity in wound treatment ». International Journal of Advanced Engineering Research and Science 9, n^o 10 (2022) : 346–64. http://dx.doi.org/10.22161/ijaers.910.39.

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Wounds are a serious public health problem and tissue healing is a complex process that requires clinical intervention. Thus, the use of biomolecules, mainly extracted from plants, presents itself as an alternative that facilitates the innate mechanisms of tissue repair. Among the different species, it is possible to highlight the Pilocarpus microphyllus, commonly known as jaborandi, which has the imidazolic alkaloid epiisopiloturin (EPI) which has emerged in research due to its anthelmintic, anti-inflammatory and antinociceptive action. Therefore, this article aims to carry out a scientific and technological prospection of P. microphyllus and EPI focused on the treatment of wounds on publication sites and articles and national and international patents deposits. For this, a survey was carried out in the following databases: Scientific Electronic Library Online (SciELO), PubMed and Web of ScienceTM for articles and the National Institute of Industrial Property of Brazil (INPI), Latin American Patent Bank (LATIPAT), European Patent Office (EPO), World Intellectual Property Organization (WIPO) and United States Patent and Trademark Office (USPTO) for patents. The search was carried out from October to November 2021, the following descriptors were used: “Pilocarpus microphyllus”, “epiisopilloturin”, “anti-inflammatory”, “in silico” and “wounds” according to the Descriptors in Sciences of Health (DeCs), as well as combinations were performed using the Boolean operator “and”. From the articles it was possible to observe that there is no published study with the use of P. microphyllus or EPI for the treatment of wounds, however they reinforce its anti-inflammatory, antinociceptive and anthelmintic activity. In addition, conducting research in silico has emerged in recent years, expanding the field of research. In patent searches for “Pilocarpus microphyllus”, the classification that registered the highest number of deposits in technological prospecting was CIP A61K, with 68.6% frequency, followed by A01N (6.9%), C07D (5.8%) , A01H (3.4%), C12N (3.4%), A61P (2.3%), A23G (2.3%), C12P (2.3%), C07K (1.1%), A23L (1.1%), A61L (1.1%), A01P (1.1%), respectively. It is noteworthy that the largest number of patents are filed in section A (human needs) and section C (chemistry and metallurgy) of the CIP, totaling 75 and 11 records, respectively. Therefore, the use of P. mycrophyllus and EPI in the development of drugs to be used in the treatment of wounds is a promising scenario for further studies due to their biological activities, which are already well described in the scientific literature.

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VANDEKERKHOF, P. « C074 Photobiology ; Increasing the efficacy by using combinations ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S74. http://dx.doi.org/10.1016/s0926-9959(97)89149-0.

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Thèses sur le sujet "C07X"

NGAHANG, KAMTE LANDRY STEPHANE. « Searching for effective natural products against Human African Trypanosomiasis (HAT) with special reference to African natural resources ». Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/428679.

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For centuries, African natives have been facing various infectious tropical illnesses, among which African trypanosomiases are some of the most frequent relevant parasitic diseases. African trypanosomiases, commonly called sleeping sickness in humans (HAT; Human African Trypanosomiasis) and Nagana in domestic livestock, affect a huge number of people living in poverty in 36 sub-Saharan countries, resulting in a key socioeconomic impact. After a century of outbreaks, due to political instability and lack of funding, around 70 million people and 50 million cattle are still at risk of exposure in Africa. Trypanosomiasis is transmitted by the bite of insects from the Glossina spp (Glossinidae) and is fatal in humans, if untreated. While taking a blood meal, infected Glossina flies can spread extracellular protozoans from the species Trypanosoma brucei. There are three morphologically indistinguishable subspecies of T. brucei. The subspecies T. b. gambiense is responsible for a chronic form of the human disease, while T. b. rhodesiense causes an acute form, which more rapidly leads to death. Both subspecies are infective to humans, whereas T. b. brucei is only infective to animals. During the early stage of the disease or hemolymphatic phase, the parasite is restricted to the blood and lymph and after months or years it invades the central nervous system resulting in various neurological symptoms including sleeping disturbance. As for other neglected tropical diseases, the chemotherapeutical arsenal against HAT is based on limited, expensive and often toxic medicines that are administered parentally in a context of poverty and lack of qualified personnell in healthcare centers. The few drugs that are available are pentamidine and suramin for the early stage disease and eflornithine (also in combination with nifurtimox) and melarsoprol for the late stage when the parasite infects the brain. Overall, the situation described above highlights the critical nature of this phenomena and the urgent need to explore new sources of potentially effective and safe compounds for therapy. In this scenario the naturally-occurring products may play a crucial role as source of bioactive drug candidates. With this vision in mind, in Chapter 2 I performed a complete phytochemical analysis on both polar and volatile compounds of T. diversifolia collected from a geographically isolated population living in Dschang, Cameroon and I assessed their biological activities (antitrypanosomal and amtimicrobial activities). The main secondary metabolites occurring in the T. diversifolia methanolic extract were isolated by column chromatography and structurally elucidated by MS and NMR techniques. Tagitinins C emerged as the most active compound against T. brucei (TC221) with an IC50 value of 0.0042 μg/mL. This activity was 4.5 times better than that of the reference drug suramin. Then I analysed the chemical composition and the antimicrobial effects of the essential oil (EO) hydrodistilled from inflorescences of T. diversifolia. Results showed that T. diversifolia EO was mostly active against Staphylococcus aureus and selectively inhibited in vitro the NAD biosynthetic enzyme NadD from S. aureus (IC50 of ∼60 g/mL). Besides its extensive utilizations in the traditional medicine, the plant is believed to have a great potential in agriculture. For this reason, I decided to evaluate the T. diversifolia polar extracts against the two-spotted spider mite Tetranychus urticae (Tetranychidae), which is one of the most economically important arthropod pests worldwide. The ethyl acetate extract resulted as the most active oviposition inhibitor, with an ED50 value of 44.3 µg.cm-3 and an ED90 of 121.5 µg.cm-3. In Chapter 3, I investigated a lipophilic extract of Onosma visianii roots containing 12% of shikonin derivatives. The phytochemical investigation of the lipophilic extract resulted in the isolation of 12 naphtoquinone derivatives which were evaluated against Trypanosoma brucei. Isobutylshikonin and isovalerylshikonin emerged as the most active naphtoquinone derivatives, showing an IC50 of 3.3 and 2.7 g/mL, respectively. Furthermore, isovalerylshikonin provided an inhibition of Glossina palpalis acetylcholinesterase (gpAChE) (IC50 = 7.1 μg/mL), stronger than isobutyrylshikonin (IC50 = 91.3 μg/mL), with a significant tse-tse fly versus human selectivity (SI = 7.2). In Chapter 4, I oriented my attention to the Apiaceae family, which is a class of aromatic plants rich of EOs. Four out of nine Apiaceae EOs resulted active against T. brucei showing an IC50 in the range 2.7-10.7 g/mL. Terpinolene, one the major isolated component of these oils, was particularly active with an IC50 value of 0.035 g/mL (0.26 µM) and a selectivity index (SI) of 180. As part of the extended family of naturally-occurring products, sesquiterpenes hold promising inhibitory effects against the bloodstream forms of T. brucei. For this reason, in Chapter 5, I decided to explore the potential of Smyrnium olusatrum EOs obtained and its main oxygenated sesquiterpenes, namely germacrone, isofuranodiene, and β-acetoxyfuranoeudesm-4(15)-ene, as potential inhibitors of T. brucei. The EOs obtained efficiently inhibited the growth of parasite with IC50 ranging from 1.9 to 4.0 g/mL. Among the isolated main EOs components, isofuranodiene exhibited a significant and selective inhibitory activity against T. brucei (IC50 = 0.6 g/mL, SI = 30). In Chapter 6, I finally selected six medicinal and aromatic plants traditionally used in Cameroon to treat several disorders, including infections and parasitic diseases. Then I evaluated the activity of their EOs against T. brucei TC221 and their selectivity against Balb/3T3 cells, used as counter-screen for cytotoxicity. The most relevant outcomes showed that the EOs from A. indica, A. daniellii and E. giganteus were the most active ones, with IC50 values of 15.21, 7.65 and 10.50 g/mL, respectively. Overall, the results of my PhD thesis provided new insights into the potential of naturallyoccurring compounds as valuable sources for the development of innovative trypanocidal drugs or botanical insecticides.

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NGOUADJEU, NGNINTEDEM MICHAEL ALLIANCE. « Synthesis and Biological Evaluation of new Ligands for the Adenosine Receptors ». Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/428735.

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Adenosine (Ado) is an endogenous nucleoside ubiquitous in mammals promoting protection and cells repair during metabolic stress conditions. Through interaction with the four Ado receptor subtypes (ARs), AR ligands have shown potential therapeutic interest for many disorders. In this work both new A2AAR agonists and A3AR antagonists were designed, synthesized and tested in vitro. Although Ado 5’-N-ethylcarboxamide derivatives like VT 7 and GCS21680 display a good affinity and selectivity for A2AAR, the development of new agonists for this receptor subtype is still a big challenge in nucleoside chemistry. In this current decade, some papers have reported that a tetrazolyl residue in 4’-position of Ado derivatives led to compounds endowed with good A2AAR affinity. Hence, in this work, compounds bearing the Nethyltetrazoyl moiety in 4’- position of the Ado ribose portion together with different arylalkylthio and arylalkylamino chains in C2-position were designed and synthesized. The new compounds were prepared using a convergent approach. To this purpose, 2,6- dichloropurine was coupled with the suitable modified sugar to afford a nucleoside which was further modified by introducing an amino group at the C6- and the suitable side chain at the C2- position. The modified sugar used in the coupling reaction was synthesized starting from the commercially available D-ribose in seven steps. The binding assay and functional study performed with the new compounds at all AR subtypes transfected on Chinese hamster ovary (CHO) cells revealed that the 2-phenylethylthio derivative was the compound endowed with the better affinity for the A2AAR/A3AR subtypes (17: Ki hA2AR = 5.8 nM; Ki hA3R = 1.2 nM). It is worthwhile to note that the presence of the ethyltetrazolyl substituent in the sugar moiety favors the interaction with the receptor respect to the ethylcarboxamido group. As expected, the new derivatives show a dual behavior at ARs, resulting A2AAR agonists and A3AR antagonists (17: IC50 at hA3AR of 8.4 nM). Furthermore, the wound healing potential of the news nucleosides was evaluated respect to VT 7, CGS21680 and epidermal growth factor (EGF, used as positive control). The compounds, 17, 19, 20, 21 and 22 showed all better wound healing potential respect to VT 7, CGS21680 and EGF. Therefore such compounds are good candidates for further investigation in in vivo model of wound healing. New A3AR antagonists were also prepared based on the observations that, the substitution of the 8-bromine atom of 8-bromo-9-ethyladenine (Ki hA2AAR = 52 nM, Ki hA3AR = 2,800 nM) with phenylacetylene shifts the preference of the resulting compound (Ki hA3AAR = 86 nM, hA2AAR= 600 nM) from A2AAR to A3AR. Hence, from these facts, three series of compounds were prepared. The first one was 8-phenylethynyladenine derivatives substituted at N-9 position with different alkyl/arylalkyl chains. The second one combines substitution on the phenyl ring of 8- phenylethynyladenine with either N-9 cyclopentyl or N9 phenethyl since they resulted being the best N-9 substituents of the first series. The third series combines a fixed para-methoxy- phenylacetylene in C-8 with either N-9 cyclopentyl or N-9 phenethyl, 2-chloro, and with different N6 substituents. The 8-arylethynyladenine derivatives substituted at 9 position with different alkyl/arylalkyl chains, and the corresponding compounds further substituted at the 2 and N6 position, were synthesized starting from commercially available adenine or 2,6- dichlorpurine in three/five steps, respectively. The results of the in vitro test reported that: N-9 cyclopentyl improved affinity while N-9 phenylethyl improved selectivity, the chlorine atom is well tolerated especially when combined with C-8 para-methoxy-phenylacetylene, the N6 substitution gave compounds with maintained selectivity in the same range of the non- substituted derivatives but with a slight decrease of the affinity. Most of the new compounds are endowed with high affinity and different degree of selectivity for the A3AR subtype. In particular, the tetrasubstituted adenine derivative 38 (Ki A3R = 8.4 nM; Ki A1R and Ki A2AR >30,000 nM) resulting the most active and selective ligand and it represents a very good ligand to study the A3AR subtype and its function.

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LUPIDI, GABRIELE. « Functionalization of Cyclic Structures for Advanced Biological and Pharmaceutical Applications ». Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/428901.

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The key components of the scaffold in pharmaceutical chemistry are ring systems, of different sizes, and are the fundamental factors of most of the drugs on the market today. Nowadays, the importance of cyclic structures is well understood by medicinal chemists, since they play a significant role in molecular properties such as the electronic distribution, three dimensionality, and molecule rigidity. They are often key factors in whole molecule properties such as lipophilicity or polarity and can determine molecular reactivity, metabolic stability, and toxicity. Cyclic structures have always fascinated organic and medicinal chemists, and many organic molecules form cycles with appealing biological properties. Research in cyclic chemistry continued to advance in synthetic methods development, conformational studies and investigation of their role for controlling biological functions. This work, carried out in the Prof. Marcantoni’s research group at the University of Camerino (Camerino, Italy) with the collaboration of Dompé S.p.A. (L’Aquila, Italy) from December 2015 to December 2018 and in the Prof. Poli’s research group from January 2018 to July 2018 at the University Pierre and Marie Curie (Paris, France), had the objective to investigate new synthetic methodologies for the functionalization of cyclic compounds, as well as the formation of cyclic structures from acyclic precursor, for advanced biological purposes. The first chapter focuses on the functionalization of the primary face of a β-cyclodextrin, in order to obtain a synthetic human receptor model, used for studying the possible interactions of this compound with a new class of biologically active compounds in development at Dompé S.p.A. The second chapter, carried out in the Poli’s research group, describes the selective C-3 functionalization trials of 2-furaldehyde and its derivatives by Directed ortho Metalation (DoM) chemistry in presence of organolithium compounds and focuses on the study of degradation products. The reaction of an alkyllithium compound with an aromatic structure bearing a Direct Metalation Group (DMG) normally leads to an ortho-metalated intermediate. Good DMGs are strong complexing or chelating groups that have the effect of increasing the kinetic acidity of protons in the ortho position. The third chapter focuses on the in-depth study of the mechanistic aspect on the formation of 5acylaminothiazoles starting from α-chloroglycinates, obtained by a new synthetic methodology developed in the Marcantoni’s research group. Finally, the fourth chapter focuses on the study of the role of Cerium trichloride in the formation of cyclic compounds via Nazarov cyclization.

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STEFANINI, NICOLA. « Optimization of Industrial Polymeric Products to Improve Quality and Reduce Environmental Impact ». Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/428907.

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The present thesis is the result of three years’ collaboration between the University of Camerino and ELANTAS Europe Srl. The strong collaboration between university and companies allows to students like others and me to do research with an industrial approach, facing with the problematics of working life. The work was carried out among the laboratory of Organic Chemistry of Prof. Enrico Marcantoni at the University of Camerino (Camerino, Italy), the R&D laboratory of ELANTAS Europe in Ascoli Piceno (Italy) and the R&D laboratory of ELANTAS PDG INC in Saint Louis (Missouri, USA). The thesis concern the environmental impact of some industrial polymeric materials. Polymeric materials are very important in modern society: they have considerable advantages over products of other origins with lower costs with the same performance. Nevertheless, they allow some applications that some years ago would have been unthinkable (microencapsulation, shape memory materials, and many others). At the same time, environmental impact is a crucial topic strictly linked to polymeric materials (as all others materials), and to the period we are living. The production of such materials is constantly growing, exceeding the production of many others materials, and it is becoming increasingly important to find ways to produce them more efficiently and to recover waste products. The consequences of a production without limitation and control could be catastrophic for the whole world and humankind too. During my PhD, I worked on three industrial products in order to reduce their environmental impact, keeping their physical properties unchanged. After a first general introduction on polymeric materials, their uses, and their production, the second chapter concern about improving a recovery process for waste PMMA. The study allowed identifying undesirable by-products formed during the thermal depolymerization of PMMA and removing them in the consequent re-polymerization by an innovative dissolution/re-precipitation method. The third and fourth chapters deal with two coatings for wires electrical insulation, one based on polyurethanes (PU) and the other on polyesterimides (PEI). With the PU-based one, the target was to reduce the amount of loss material during the application stage and to increase the speed of application in order to reduce the energy consumption of the process. Whereas with the PEI-based enamel the purpose was to synthesized a solvent-free product using a twin-screw extruder and using recycled PET as alternative raw material to form the polyester part. The extruder technology is less energy consuming compare to the batches ones and allows working without solvents, since it can work with high viscosity materials. Moreover, the extruded product, with an additional system, can be potentially applied onto the wire with a higher thickness compare to the respective solventbased product, allowing a greater flow of current along the wire, thus improving the performance of the finished products (i.e. reducing the charging time of electrical motors).

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TOMBESI, ALESSIA. « Advanced functional coating for self-cleaning and anti-corrosion applications ». Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/432253.

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This thesis is focused on the preparation of organic-inorganic hybrid systems with targeted properties. In particular, thesis presents the synthesis, characterization and application of two types of functional coating, which are hydrophobic / self-cleaning and anticorrosion coatings. Chapter 1 is dedicated to general introduction and the state of art of advanced functional coating. The chapter includes a brief description of the current functional market size and possible applications of functional coatings. Chapter 2 provides a general introduction of superhydrophobic coatings, their possible applications on the glass surface and methods to produce them. In the chapter 3, sol-gel methods has been describe in detail. The sol gel process by employed alkoxysilanes was used in this work to fabricate the functional coatings. Chapters 4, 5 and 6 describes the experimental works of this thesis. In the chapter 4, the solgel process and dip-coating technique were employed for the preparation of hydrophobic self-cleaning hybrid materials. The process has been optimized to obtain transparent and highly hydrophobic sol-gel coatings by using different alkoxysilane. These hybrid sol-gel coatings are a good alternative to provide anti-stick and easy-to-clean properties to glass substrates being quite easy to scale up. In the chapter 5, a method for the preparation of transparent superhydrophobic silica coatings on glass substrates via aerosol‐assisted chemical vapour deposition (AACVD) is described. A multi-layer process to produce dual scale silica nanoparticles films, by using different functional alkoxysilanes was investigated. In this study, a novel strategy to achieve highly transparent superhydrophobic glass surfaces using AACVD of alkoxysilanes, to produce surfaces with excellent durability is described. This shows great potential to obtain silica superhydrophobic films for large–scale applications Finally, in the chapter 6, a preliminary study about the protective barrier coating to protect the integrity of the silver from deleterious chemical degradation in a mirror structure is investigated. Sol-gel hybrid coating has been deposited on mirror to avoid corrosion degradation process of silver layer. Salt spray test was performed on mirror coated with hybrid coating and the results showed a no signs of corrosion on the mirror. The results indicate excellent barrier protection performance of the coating.

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Zhang, Huajun. « Functional characterisation of cardiac progenitors from patients with ischaemic heart disease ». Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3b8a7199-c077-436c-bb89-cd354efe4414.

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Ischaemic heart disease (IHD) is the leading cause of death worldwide. Currently, even optimal medical therapies do not attenuate deterioration of the left ventricular (LV) function completely. Stem cell therapies, and recently cardiac stem cell therapies, have emerged as potential novel treatments for IHD. However, clinical evidence from randomised controlled studies has shown mixed results. Thus understanding what patient-related factors may affect the therapeutic performance of the cells may help improving treatment outcomes. The studies described in this thesis aim to understand how cardiac progenitor cells (CPCs) can re-vascularise ischaemic myocardium and promote functional repair of the heart. Resident CPCs were isolated and expanded from the right atrial appendage of 68 patients following the ‘cardiosphere’ method (cardiosphere-derived cells or CDCs). They resemble mesenchymal progenitors as they lack the expression of endothelial and haematopoietic cell surface markers but express mesenchymal progenitor cell markers (e.g. CD105, CD90). Cell function was evaluated by support of angiogenesis, mesenchymal lineage differentiation potential in vitro, and improvement in heart function in vivo. Notably in vitro, CDC from different patients differed in their angiogenic supportive and differentiation potentials. In a rodent model of myocardial infarction (MI), transplantation of CDC reduced infarct size significantly (p<0.05). However, only those CDCs with a robust pro-angiogenic ability in vitro improved vessel density and heart systolic function (p<0.05) in vivo. A multiple regression model, which accounted for 51% of the variability observed, identified New York Heart Association (NYHA) class, smoking, hypertension, type of ischaemic disease and diseased vessel as independent predictors of angiogenesis. In addition, gene expression analyses revealed that differential gene expression of several extracellular matrix components (e.g. CUX1, COL1A2, BMP1 genes and microRNA-29b) could explain the differences observed in CDC’s vascular supportive function. In summary, this is the first description of variability in the pro-angiogenic and differentiation potential of CDCs and its correlation with their therapeutic potential. This study indicates that patient stratification may need to be included in the design of future trials to improve the efficacy of cell-based therapies.

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Krutikova, Sofya. « Schooling and beyond : essays on skill formation and learning in deprived contexts ». Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:92f43078-c076-41e0-84da-6f9f93e16b0b.

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This thesis explores learning and formation of cognitive and non-cognitive skills within formal and non-formal environments, as well as the impact of migration on fertility behaviour in three separate empirical studies. In two of the papers (Chapters 2 and 4) I utilise a 13 year individual-level panel data-set from rural Tanzania, while the third one (Chapter 3) is based on cross-sectional data that I collected in urban Bombay slums in 2007. I consider skill acquisition and learning in a number of spheres. First, I adopt the conventional notion of school-based learning and examine the role of income shocks in evolution of schooling inequalities, in rural Tanzania. I find evidence of shock-induced permanent changes in the schooling of those affected by the shocks in later childhood (age 7-13), 10-13 years later. Further, I find suggestive evidence that the household short-term labour response may to be one of the mechanisms for these long-term effects. Next, I broaden the definition of learning to include acquisition of non-cognitive skills. Although there is growing recognition of the importance of these, there is no evidence, within a developing country context, on effectiveness of interventions targeting them. The second paper is an evaluation of a long-term non-formal schooling intervention in Bombay slums, which works on raising non-cognitive skills, including self-esteem, a sense of agency, and aspirations of children. It shows that, like cognitive skills, non-cognitive skills can be effectively raised through sustained intervention, offering evidence of substantial positive programme effects. The final paper turns to examining the impact of migration among young women on fertility behaviour. Econometric panel data methods are combined with an instrumenting strategy to offer evidence of a causal positive impact of migration on the age at which women start having children, which is shown to be likely to have permanent effects on total fertility. The findings are most consistent with the presence of temporary post migration disruption effects.

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Hardy, Edward. « Supersymmetry and electroweak fine tuning ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:832194dd-c075-4f18-bc88-3822fa745aea.

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Low scale supersymmetry (SUSY) is a compelling solution to the electroweak hierarchy problem. However, increasingly strong limits on the masses of superpartners, first from LEP and now the LHC, mean that the simplest models require significant fine tuning. This thesis is dedicated to the study of a possible alternative low energy superpartner spectrum, natural SUSY, in which only superparticles directly involved in stabilising the electroweak scale are light, alleviating collider limits and potentially reducing tuning. After reviewing how low scale SUSY is motivated by the hierarchy problem, we build a model of SUSY breaking and mediation that successfully generates a natural SUSY spectrum. This also suppresses the first two generation fermion Yukawas, and leads to small parameters in the hidden sector, which are required for successful SUSY breaking. A challenge in models of natural SUSY is raising the physical Higgs mass to 125 GeV, and we study the possibility that this could occur through the addition of a singlet to the theory. If stops are very light, the coupling of the singlet to the Higgs needs to be so large that it becomes nonperturbative before the scale of grand unification, raising the concern that precision gauge coupling unification may be upset. However, we find that this is not necessarily the case. Rather it is possible this could correct for the present ∽ 3% discrepancy in the two-loop minimal supersymmetric model's unification prediction. We then turn to the fine tuning in models of natural SUSY, emphasising that this should be measured with respect to the theory's ultraviolet (UV) parameters. We show that the first two generation sfermions can be made relatively heavy, beyond LHC reach, without introducing tuning. However, the gluino generates a significant tuning through the stops during the renormalisation group flow. As a result, there is no fine tuning benefit in reducing the stop masses below (50 - 75)% of the weak scale gluino mass, and we obtain strong lower bounds on the tuning of theories compatible with collider limits. We also study theories with Dirac gauginos, which have relatively low fine tuning even if the scale of mediation is high. Finally, we consider the effect of relaxing a common assumption and allowing the hidden SUSY breaking sector to modify the running of the visible sector soft masses. This may plausibly occur in realistic models and could dramatically reduce the fine tuning of SUSY theories.

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Hawas, Ahmed. « Peri-implantis : associated microbiota, biofilm formation and decontamination ». Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/periimplantis-associated-microbiota-biofilm-formation-and-decontamination(a8d44329-c073-4359-a2cf-d8866c5cc84b).html.

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Peri-implantitis is a bacterially induced inflammatory condition that results in resorption of the bone supporting an implant. The methods for treating it are mainly empirical, and none have been shown to be universally successful. The first part of this research aimed to identify and compare the composition of the microbiota around dental implants with and without peri-implantitis. Subgingival plaque samples were collected from twenty-one subjects and samples were cultured using non-selective media and bacterial identification was carried out using 16S rRNA PCR. The second phase of the study investigated surface characteristics of implants that could influence the formation of a biofilm. Using a clinically relevant organism (Streptococcus oralis), an in vitro biofilm was developed and biofilm formation on four titanium implant surfaces exhibiting varying degrees of roughness with and without fluoride ions incorporated was evaluated using confocal laser scanning electron microscopy, bacterial culturing and scanning electron microscopy. The final phase examined the effects of mechanical debridement and air-polishing using glycine or 45S5 bioactive glass powders in re-establishing biocompatibility of the previously contaminated implant surfaces. Biocompatibility of the surfaces was tested using cell culture with alveolar human osteoblasts for cell viability, proliferation and cell differentiation. Results showed that a complex subgingival microbiota was found around dental implants. Peri-implantitis was associated with an increased bacterial load. Filifactor alocis, Streptococcus constellatus, Parvimonas micra and Actinomyces meyeri were significantly more prevalent in peri-implantitis, while Veillonella parvula/ dispar and Neisseria elongata were more prevalent in healthy sites. There were no significant differences in biofilm volume, surface area covered by the biofilm, nor number of bacteria found on any of the surfaces tested or at different levels within the biofilm suggesting that once colonization has been established, the effect of the surface diminishes with maturation of the biofilm. Although cleaning efficiency was different, all decontamination methods tested were shown to yield a biocompatible implant surface.

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Higgins, Anna-Gret. « Counsellors' experience of being changed by clients : a narrative autoethnographic inquiry ». Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/counsellors-experience-of-being-changed-by-clients-a-narrative-autoethnographic-inquiry(b87cc478-c073-4fb3-a925-28aa3b105d78).html.

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This thesis addresses four research questions: 1. Are counsellors changed by their clients? 2. If so, how do they make meaning of any change? 3. How does the academic literature explain these changes? 4. How do counsellors ensure change is positive?Previous research has largely focused on the negative effects of clients' stories on counsellors. The potentially positive impact is relatively unexplored - despite the fact that research suggests that it is possible for people who directly experience a wide range of traumatic experiences to grow as a result (Tedeschi & Calhoun, 1996). Moreover, a handful of research studies has suggested that it is possible to experience these changes vicariously (Manning-Jones, deTerte & Stephens, 2015). This thesis describes a qualitative research study carried out with eight counsellors who worked either in a hospice (counselling clients experiencing bereavement or illness) or in private practice (counselling clients who had experienced sexual violence). Narrative inquiry and autoethnography were used to collect and analyse counsellors' stories of being changed by their clients and re-presented as poetic representation, visual art and polyvocal texts. The results show that counsellors do indeed share stories of being changed: sometimes for the worse but often for the better. These changes are in the areas of self-perception, interpersonal relationships and life philosophy and are largely consistent with conceptualisations of vicarious posttraumatic growth. However, what drives change is different. In hospice counsellors, mortality awareness is the driver for change; whereas human cruelty and brutality is the driver in counsellors who work with clients who have experienced sexual violence. Counsellors draw on a number of alternative discourses to make meaning of their experience and this reflects different counselling modalities. The counsellors' stories of change may represent personal growth or reflect western metanarratives linked to a quest for identity. These findings are discussed in relation to the training and supervision of practitioners.

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Livres sur le sujet "C07X"

Thomson, Margaret L., et Joseph H. Brisch, dir. Lime : Building on the 100-Year Legacy of The ASTM Committee C07. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959 : ASTM International, 2012. http://dx.doi.org/10.1520/stp1557-eb.

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Lime : Building on the 100-year legacy of the ASTM Committee C07. West Conshohocken, PA : ASTM International, 2012.

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Titus, Donald D. General Chemistry Lab II : Chemistry C074. Kendall/Hunt Publishing Company, 1993.

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Realms of Reading : Grades 4-8 (Accelerated Reader Book Set C07). Renaissance Learning Inc, 2000.

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Chapitres de livres sur le sujet "C07X"

Tate, Michael J. « ASTM Committee C07 on Lime : A Reflection ». Dans Lime : Building on the 100-Year Legacy of The ASTM Committee C07, 3–13. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959 : ASTM International, 2012. http://dx.doi.org/10.1520/stp20120020.

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Tate, Michael J. « ASTM Committee C07 on Lime : A Reflection ». Dans Lime : Building on the 100-Year Legacy of The ASTM Committee C07, 1–11. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959 : ASTM International, 2012. http://dx.doi.org/10.1520/stp20120020t.

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« Six Orchestral Serenades from South Germany and Austria, Part 2 ». Dans Recent Researches in the Music of the Classical Era, 70. A-R Editions, 2003. http://dx.doi.org/10.31022/c070.

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« Three Masses from Vienna ». Dans Recent Researches in the Music of the Classical Era, 71. A-R Editions, 2004. http://dx.doi.org/10.31022/c071.

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« Arias for Francesco Benucci ». Dans Recent Researches in the Music of the Classical Era, 72. A-R Editions, 2004. http://dx.doi.org/10.31022/c072.

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Cannabich, Christian. « Ballet Music Arranged for Chamber Ensemble ». Dans Recent Researches in the Music of the Classical Era, 73. A-R Editions, 2004. http://dx.doi.org/10.31022/c073.

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Travers, John. « Eighteen Canzonets for Two and Three Voices ». Dans Recent Researches in the Music of the Classical Era, 74. A-R Editions, 2005. http://dx.doi.org/10.31022/c074.

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Grenser, Johann Friedrich. « Landsby Mölleren i Provence (Les Meunièrs provenceaux) ». Dans Recent Researches in the Music of the Classical Era, 75. A-R Editions, 2006. http://dx.doi.org/10.31022/c075.

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« Der Stein der Weisen ». Dans Recent Researches in the Music of the Classical Era, 76. A-R Editions, 2007. http://dx.doi.org/10.31022/c076.

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Grétry, Lucile. « Le Mariage d'Antonio ». Dans Recent Researches in the Music of the Classical Era, 77. A-R Editions, 2008. http://dx.doi.org/10.31022/c077.

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Actes de conférences sur le sujet "C07X"

Paulino, Yvette C., Alisha N. Yamanaka, Patrick F. P. Sotto, Grazyna Badowski, Lynne R. Wilkens et Brenda Y. Hernandez. « Abstract C074 : Areca (betel) nut chewing and metabolic conditions ». Dans Abstracts : Eleventh AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; November 2-5, 2018 ; New Orleans, LA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp18-c074.

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Sipilä, Jussi, Susanna Ylönen et Kari Majamaa. « C07 Intergenerational cag stability across chromosome 4 haplogroups ». Dans EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/jnnp-2018-ehdn.78.

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Chen, Hang, Katherine Slemmons, Heather Ha, Robert Stanley, Qian Cai, Irene Yuan, Lee Helman et Ping Cao. « Abstract C072 : Discovery of highly potent and selective covalent inhibitors of FGFR4 ». Dans Abstracts : AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics ; October 26-30, 2019 ; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-c072.

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Arceo, Candice S., Grazyna Badowski, Gary R. W. Denton et Renata Bordallo. « Abstract C075 : Indoor radon exposure and thyroid cancer incidence among Guam residents ». Dans Abstracts : Eleventh AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; November 2-5, 2018 ; New Orleans, LA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp18-c075.

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Gathirua-Mwangi, Wambui G., Julie R. Palmer, Victoria Champion, Lucile L. Adams-Campbell, Andrew Marley, Michele Forman, Lynn Rosenberg et Kimberly A. Bertrand. « Abstract C072 : Maximum body mass index and breast cancer incidence in Black women ». Dans Abstracts : Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; September 20-23, 2019 ; San Francisco, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp19-c072.

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Hossain, Fokhrul, Denise Danos, Aubrey Gilliland, Claudia Leonardi, Tekeda Ferguson, Neal Simonsen, Qingzhao Yu, Om Prakesh, Richard Scribner et Lucio Miele. « Abstract C070 : Social determinants of health disparities in triple-negative breast cancer in Louisiana ». Dans Abstracts : Eleventh AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; November 2-5, 2018 ; New Orleans, LA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp18-c070.

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Moore, Jaleesa, Maureen Sanderson, Tuya Pal, Mary Kay Fadden, Steffie-Ann Dujon, Sonya Reid, Anne Tezak et Loren Lipworth. « Abstract C075 : Association of obesity with breast cancer subtypes among non-Hispanic Black women ». Dans Abstracts : Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; September 20-23, 2019 ; San Francisco, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp19-c075.

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Percy-Laurry, Antoinette, et Zaria Tatalovich. « Abstract C07 : Utilizing state cancer profiles for communicating lung cancer disparities ». Dans Abstracts : Sixth AACR Conference : The Science of Cancer Health Disparities ; December 6–9, 2013 ; Atlanta, GA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7755.disp13-c07.

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Kim, Ji-Won, Kui-Jin Kim, Ji Hea Sung, Koung Jin Suh, Ji Yun Lee, Se Hyun Kim, Jin Won Kim et al. « Abstract C074 : Preclinical study of antitumor effect of alpelisib combined with paclitaxel in gastric caner ». Dans Abstracts : AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics ; October 26-30, 2019 ; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-c074.

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Díaz, Carola T. Sánchez, et Garth H. Rauscher. « Abstract C078 : Racial/ethnic disparities in breast cancer survival by subtypes : The role of obesity ». Dans Abstracts : Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved ; September 20-23, 2019 ; San Francisco, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp19-c078.

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