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Articles de revues sur le sujet « C03X »

Auteur : Grafiati
Publié le 9 mars 2023

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1

León Pacheco, Rommel Igor, Ender Manuel Correa Álvarez, Jorge Luis Romero Ferrer, Heriberto Arias Bonilla, Juan Camilo Gómez-Correa, Marlon Jose Yacomelo Hernández et Lumey Pérez Artiles. « Accumulation of degree days and their effect on the potential yield of 15 eggplant (Solanum melongena L.) accessions in the Colombian Caribbean ». Revista Facultad Nacional de Agronomía Medellín 72, no 3 (1 septembre 2019) : 8917–26. http://dx.doi.org/10.15446/rfnam.v72n3.77112.

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The growing degree-days (GDD) provide an estimate of the accumulated thermal energy available for the development of a crop. The use of GDD allows measuring the heat requirements associated with the phenological stages of the crop, which allows in turn, to predict when a certain plant stage will occur knowing the daily temperatures. The aim of this study was to establish relationships among the effect of degree days (DD) to vegetative growth, first flowering and fructification (VG, Fl and Fr), on total yield per plant (TY/P) of eggplant grown under open-field conditions employing a randomized complete block design with 15 genotypes and four replicates. The results showed that: 1) The genotypes that initiated fruit production in less time required fewer GDD (892.14-1,077.71 °C) for this phenological phase, obtaining higher productivity. 2) The genotypes C035 and C040 had an average yield higher than the national average with values of 83.75 and 84.86 t ha-1, being identified as future varieties to be produced in the Caribbean region. 3) The Caribbean region is suitable for the establishment of the crop as there were no events with limiting temperatures for this species (higher than 35 °C and lower than 15 °C). 4) The principal component analysis showed associations among the variable YT/P with the genotypes C011, C042, and C015; meanwhile, C032, C025, and C028 were associated with the variables DD to VG, Fl, and Fr. These results would be useful in developing a model to estimate yield with DD.
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FERGUSON, J. « C039 Photopatch testing ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S67. http://dx.doi.org/10.1016/s0926-9959(97)89116-7.

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DEGRUIJL, F., R. BERG, H. VANSTEEG et H. VANKRANEN. « C033 Mechanisms of UV carcinogenesis ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S65. http://dx.doi.org/10.1016/s0926-9959(97)89107-6.

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GARMYN, M. « C032 Photoageing and chronic effects ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S65. http://dx.doi.org/10.1016/s0926-9959(97)89109-x.

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MARKS, R. « C034 Sunlight and skin cancer ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S65—S66. http://dx.doi.org/10.1016/s0926-9959(97)89110-6.

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ANDERSEN, K. « C035 Useful patch test batteries ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S66. http://dx.doi.org/10.1016/s0926-9959(97)89111-8.

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Sangiogo, Maurício, Daniela Pimentel Rodriguez, Renata Moccellin, Johan Manuel Murcia Bermudez, Bianca Obes Corrêa et Andrea Bittencourt Moura. « Foliar spraying with bacterial biocontrol agents for the control of common bacterial blight of bean ». Pesquisa Agropecuária Brasileira 53, no 10 (octobre 2018) : 1101–8. http://dx.doi.org/10.1590/s0100-204x2018001000003.

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Abstract: The objective of this work was to evaluate the effect of foliar spraying with bacterial biocontrol agents (BBAs) on the control of common bacterial blight (CBB) of bean, and on the induction of systemic resistance in bean plants. CBB control by BBAs was evaluated by spraying bean leaves 48 and 24 hours before and after pathogen inoculation (BPI and API, respectively), with: DFs93, Bacillus cereus; DFs513, Pseudomonas veronii; DFs769, B. cereus; the C01 combination, DFs93 + DFs769 + DFs831 (Pseudomonas fluorescens); the C03 combination, DFs348 (Bacillus sp.) + DFs769 + DFs831; and water (control). Systemic effects were analyzed after spraying DFs513, DFs769, C03, and water 72 and 48 hours BPI. Phaseolin production induced by DFs348, DFs513, DFs769, DFs831, and water was also assessed. DFs513, DFs769, and C03 significantly reduced disease incidence (area under disease progress curve), regardless of spraying time and disease severity when sprayed 72 and 48 hours BPI. The DFs769 and DFs831 isolates induced the accumulation of phytoalexin (phaseolin). Therefore, DFs513, DFs769, and C03 show potential for the biocontrol of CBB when applied preventively on bean leaves, besides inducing systemic resistance.
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ORTONNE, J. « C031 The molecular bases of tanning ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S65. http://dx.doi.org/10.1016/s0926-9959(97)89108-8.

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KANERVA, L., R. JOLANKI et T. ESTLANDER. « C038 Patch test battery for plastics ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S66—S67. http://dx.doi.org/10.1016/s0926-9959(97)89114-3.

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Legfros, R. Z., T. Sakae, C. Bautista, M. Retino et J. P. Legeros. « Magnesium and Carbonate in Enamel and Synthetic Apatites ». Advances in Dental Research 10, no 2 (novembre 1996) : 225–31. http://dx.doi.org/10.1177/08959374960100021801.

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This study aimed to: determine the Mg and C03 distribution in the outer (surface), middle, and inner (closest to the enamel-dentin junction, EDJ) layers of human enamel; and determine the factors affecting the incorporation of Mg into synthetic apatites and the consequence of such incorporation on the properties of the apatites. Results demonstrated that the concentrations of Mg, C03, and organic components increased from the surface to the inner layers close to the EDJ and a difference in crystallinity from the outer to the inner layers. Initial results indicated that the extent of dissolution of the inner layer enamel is greater than that in the outer or surface enamel. Results on synthetic apatites showed the following: (1) Limited Mg incorporation into apatite was dependent on solution [Mg/Ca] molar ratio, temperature, pH, and the presence of C03 or fluoride (F); (2) incorporation of Mg causes reduction in crystallinity and an increase in the extent of dissolution of the apatite: (3) the negative effect of Mg on the properties of apatites is synergistic to that of C03 and antagonistic to that of F; and (4) exposure to acid of Mg-containing apatites causes the dissolution of Mg-rich apatite and precipitation of Mg-poor apatite. The observed decrease in the [Mg/Ca] of enamel and synthetic apatites after acid exposure may explain the observed 'preferential loss' of Mg and C03 in the initial stages of caries.
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Atayde, Vanessa D., Mauro Cortez, Renata Souza, José Franco da Silveira et Nobuko Yoshida. « Expression and Cellular Localization of Molecules of the gp82 Family in Trypanosoma cruzi Metacyclic Trypomastigotes ». Infection and Immunity 75, no 7 (16 avril 2007) : 3264–70. http://dx.doi.org/10.1128/iai.00262-07.

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ABSTRACT A member of the Trypanosoma cruzi gp82 family, expressed on metacyclic trypomastigote surface and identified by monoclonal antibody (MAb) 3F6, plays a key role in host cell invasion. Apart from the gp82 defined by MAb 3F6, no information is available on members of this protein family. From cDNA clones encoding gp82 proteins sharing 59.1% sequence identity, we produced the recombinant proteins J18 and C03, the former containing and the latter lacking the epitope for MAb 3F6. Polyclonal antibodies to J18 and C03 proteins were generated and used, along with MAb 3F6, to analyze the expression and cellular localization of gp82 family members in metacyclic forms of CL and G strains, which belong to highly divergent genetic groups. By two-dimensional gel electrophoresis and immunoblotting, molecules of 82 to 86 kDa, focusing at pH 4.6 to 5.4, and molecules of 72 to 88 kDa, focusing at pH 4.9 to 5.7, were visualized in CL and G strains, respectively. Flow cytometry and microscopic analysis revealed in both strains similar expression of MAb 3F6-reactive gp82 in live and permeabilized parasites, indicating its surface localization. The reaction of live parasites of both strains with anti-J18 antibodies was weaker than with MAb 3F6 and was increased by permeabilization. Anti-C03 antibodies bound predominantly to flagellar components in permeabilized G strain parasites, but in the CL strain the flagellum was not the preferential target for these antibodies. Host cell invasion of metacyclic forms was inhibited by J18 protein, as well as by MAb 3F6 and anti-J18 antibodies, but not by C03 protein or anti-C03 antibodies.
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Patton, Dean, Susan Marlow, Monder Ram et Kul Sanghera. « Interpretive Analysis as an Evaluative Tool : The Case of Mustard.UK.Com, a High-Growth Small Business Programme ». Environment and Planning C : Government and Policy 21, no 6 (décembre 2003) : 813–24. http://dx.doi.org/10.1068/c031.

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Morello-Frosch, Rachel A. « Discrimination and the Political Economy of Environmental Inequality ». Environment and Planning C : Government and Policy 20, no 4 (août 2002) : 477–96. http://dx.doi.org/10.1068/c03r.

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Over the last decade there has been a surge in academic and scientific inquiry into disparities in environmental hazards among diverse communities. Much of the evidence points to a general pattern of disproportionate exposures to toxics among communities of color and the poor, with racial differences often persisting across economic strata. Although results have implications for the politics of environmental decisionmaking, most of these analyses are limited to illustrating how inequities in exposures and health risks are spread across the landscape, while shedding little light on their origins or the reasons for their persistence. Previous attempts to theorize the causes of environmental inequality have focused on procedural justice in the regulatory arena, emphasizing civil rights jurisprudence and social theories on individual and institutional discrimination. Although these approaches offer insights into the epistemology of environmental inequality, they fail adequately to account for the political economy of discrimination relating to industrial location behavior and racialized labor markets. By integrating relevant social and legal theories with a spatialized economic critique, this paper formulates a more supple theory of environmental discrimination. How the political economy of place shapes distributions of people and pollution and ultimately gives rise to environmental inequality are revealed by exploring the following factors: historical patterns of industrial development and racialized labor markets; suburbanization and segregation; and economic restructuring. This multidisciplinary approach to theorizing the dynamic of environmental discrimination provides a new framework for future policymaking and community organizing to address environmental and economic justice. Implications of this broader framework for policy and politics are discussed in the conclusion.
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PODMORE, P. « C037 Series for shoes and clothing dermatitis ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S66. http://dx.doi.org/10.1016/s0926-9959(97)89112-x.

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Padua, R., C. Le Pogam, S. Beurlet, M. Reboul, P. Krief, R. West, M. Pla, D. Charron et C. Chomienne. « C035 DNA vaccination as immunotherapy adjuvant in MDS ». Leukemia Research 33 (mai 2009) : S52. http://dx.doi.org/10.1016/s0145-2126(09)70073-6.

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Hasselluhn, Marie C., Lukas J. Vlahos, Dafydd Thomas, Alvaro Curiel Garcia, Amanda R. Decker, Tanner C. Dalton, Stephen A. Sastra, Carmine F. Palermo, Andrea Califano et Kenneth P. Olive. « Abstract C032 : Combination CAF/myeloid targeting in PDAC ». Cancer Research 82, no 22_Supplement (15 novembre 2022) : C032. http://dx.doi.org/10.1158/1538-7445.panca22-c032.

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Abstract Immunotherapy has revolutionized clinical care for many cancers, yet these treatments fail to control disease in many patients and new strategies are needed to improve anti-tumor immunity and enhance response rates. There is great need for an increased understanding of the cellular crosstalk within tumors and the identification of stromal and immune populations involved in shaping the tumor microenvironment (TME). Local immunosuppression (LIS) is one of the striking hallmarks of Pancreatic Ductal Adenocarcinoma (PDAC), a disease that is highly resistant to existing immunotherapies. Oncogenic Kras activation in tumor cells promotes the invasion and proliferation of tumor-supporting stromal cells, while excluding cancer-targeted cytotoxic T cells. LIS is mediated by multiple subtypes of cancer-associated fibroblasts (CAFs) and myeloid cells resident within the tumor parenchyma. Multiple prior attempts to reverse LIS in PDAC by targeting individual stromal cell populations have been unsuccessful, alluding to the complexity of stromal crosstalk within the TME. The stromal diversity of PDAC complicates investigating paracrine cascades involving multiple cell types. To decipher diverse drug effects on altering the TME, we employ in vivo studies in mouse models recapitulating the human disease, as well as a novel tumor explant model that enables the short-term culture of intact human or murine PDAC. Importantly, PDAC explants maintain their histopathological architecture and cellular diversity over time. This medium-throughput platform allows for testing of multiple drugs and mechanistic hypotheses in the native PDAC TME. We show in preliminary data that Smoothened inhibition (SMOi) decreases proliferation and activity of myCAFs, but provokes the expansion of CD11b-positive myeloid cells in vivo. Thus, we hypothesize that LIS in PDAC is maintained by a delicate balance between myCAFs and myeloid cells, preventing effective T cell invasion. Single cell RNA-seq data comparing ctrl vs. SMOi-treated murine PDAC elucidates stromal subpopulations involved in the LIS phenotype and guides the identification of myeloid subtypes emerging after SMOi. Strikingly, we demonstrated that simultaneous SMOi and targeting myeloid cells via anti-Gr1 or CCR1 inhibition (CCR1i) significantly elevates cytotoxic T cell numbers within the TME. We are currently investigating whether the activity of these T cells may be further potentiated through combination with immunomodulatory agents. By testing various treatment combination in the same TME, we will identify the best synergistic effects for future immunotherapy approaches in human PDAC. In summary, we are elucidating the complex mechanism behind LIS in PDAC by employing our novel explant culture system alongside in vivo studies. We aim to develop a translatable regimen to neutralize LIS, reactivating the cytotoxic T cells in the tumor periphery to invade, proliferate, and attack cancer cells. Citation Format: Marie C. Hasselluhn, Lukas J. Vlahos, Dafydd Thomas, Alvaro Curiel Garcia, Amanda R. Decker, Tanner C. Dalton, Stephen A. Sastra, Carmine F. Palermo, Andrea Califano, Kenneth P. Olive. Combination CAF/myeloid targeting in PDAC [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer; 2022 Sep 13-16; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2022;82(22 Suppl):Abstract nr C032.
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ITO, Shinichiro, Taketo MIZOTA, Katsumi AOKI, Takeshi ASAI, Motomu NAKASHIMA et Kazuya SEO. « C03 Scientific Analysis of Olympic Games ». Reference Collection of Annual Meeting 2008.9 (2008) : 3–4. http://dx.doi.org/10.1299/jsmemecjsm.2008.9.0_3.

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SCHWARZ, T. « C030 Biological effects and cellular responses to UV radiation ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S64—S65. http://dx.doi.org/10.1016/s0926-9959(97)89106-4.

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Zhao, Houyu. « Smooth Solutions of a Class of Iterative Functional Differential Equations ». Abstract and Applied Analysis 2012 (2012) : 1–13. http://dx.doi.org/10.1155/2012/954352.

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By Faà di Bruno’s formula, using the fixed-point theorems of Schauder and Banach, we study the existence and uniqueness of smooth solutions of an iterative functional differential equationx′(t)=1/(c0x[0](t)+c1x[1](t)+⋯+cmx[m](t)).
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Pułka, Andrzej. « C03 : Transaction level models analyzer in prolog ». IFAC Proceedings Volumes 37, no 20 (novembre 2004) : 278–83. http://dx.doi.org/10.1016/s1474-6670(17)30611-0.

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Ramarozatovo, L., F. M. P. Randrianasolo, M. Ranivontsoarivony, H. Ravelomanantena, C. Ratrimoarivony et F. Rapelanoro Rabenja. « C035 - Observations malgaches d’association lupus érythémateux et thyroïdite de Hashimoto ». Annales de Dermatologie et de Vénéréologie 134, no 1 (janvier 2007) : 46. http://dx.doi.org/10.1016/s0151-9638(07)89068-5.

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Diallo, O., R. Zoungrana, F. Barro-Traoré, L. C. Lougué-Sorgho, M. Windsouri, A. Siko, A. Kabré, K. Ouoba, R. Cissé et L. Kam. « C037 - Masses et fistules de la région frontonasale de l’enfant ». Annales de Dermatologie et de Vénéréologie 134, no 1 (janvier 2007) : 47. http://dx.doi.org/10.1016/s0151-9638(07)89070-3.

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Lallogo, S., S. Tiendrebeogo, S. R. M. Tiendrebeogo, M. Dabal et F. Barro-Traore. « C038 - Manifestations cutanées de l’intoxication à l’arsenic au Burkina Faso ». Annales de Dermatologie et de Vénéréologie 134, no 1 (janvier 2007) : 47–48. http://dx.doi.org/10.1016/s0151-9638(07)89071-5.

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GOOSSENS, A. « C036 The use of patch-test batteries : Pros and cons ». Journal of the European Academy of Dermatology and Venereology 9 (septembre 1997) : S66. http://dx.doi.org/10.1016/s0926-9959(97)89113-1.

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Ciprut, A., et F. Akdas. « C037 Outcome of cochlear implantation in children with cochlear malformations ». International Journal of Pediatric Otorhinolaryngology 75 (mai 2011) : 39–40. http://dx.doi.org/10.1016/s0165-5876(11)70205-1.

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Aksoy, G., T. Kandogan, L. Olgun, M. Z. Özüer, G. Gültekin et G. Malkoç. « C039 Evaluation of articulatory characteristics of voice after pediatric CI ». International Journal of Pediatric Otorhinolaryngology 75 (mai 2011) : 40. http://dx.doi.org/10.1016/s0165-5876(11)70207-5.

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Merzoug, L., S. Skali et K. H. Benchikhi. « C033 - Profil épidémiologique du psoriasis pustuleux : étude rétrospective sur 16 ans ». Annales de Dermatologie et de Vénéréologie 134, no 1 (janvier 2007) : 45. http://dx.doi.org/10.1016/s0151-9638(07)89066-1.

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Fauvel Gauberti, A. M. « C034 - Exemples de soins donnés aux bébés dans le monde : réflexions ». Annales de Dermatologie et de Vénéréologie 134, no 1 (janvier 2007) : 45–46. http://dx.doi.org/10.1016/s0151-9638(07)89067-3.

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LEE, M. « C031 Relaxation methods for blood pressure (BP) overswinging ; Need for timing ». American Journal of Hypertension 11, no 4 (avril 1998) : 55A. http://dx.doi.org/10.1016/s0895-7061(97)90906-7.

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MEERT, R. « C033 A simple way to mark guidelines on blood pressure cuffs ». American Journal of Hypertension 11, no 4 (avril 1998) : 56A. http://dx.doi.org/10.1016/s0895-7061(97)90908-0.

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Haumann, S., N. Wardenga, Th Lenarz, A. Lesinski-Schiedat et A. Büchner. « C032 Testing speech perception with varying Speakers, speech and noise levels ». International Journal of Pediatric Otorhinolaryngology 75 (mai 2011) : 38–39. http://dx.doi.org/10.1016/s0165-5876(11)70200-2.

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Chan, L., L. Gu et R. Wells. « C036 The effects of iron overload on hematopoiesis in the mouse ». Leukemia Research 33 (mai 2009) : S53. http://dx.doi.org/10.1016/s0145-2126(09)70074-8.

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Hutson, S. « Colloquium C03 : Modeling brain metabolism : challenges and controversies ». Journal of Neurochemistry 94 (juin 2005) : 9–10. http://dx.doi.org/10.1111/j.1474-1644.2005.03228_6.x.

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IKEUCHI, Toru, Tetsuo TSUKUNI, Masahiro NISHIKAWA et Tadashi EGAMI. « 1A2-C03 Development of Experimental space Elevator Climber ». Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2010 (2010) : _1A2—C03_1—_1A2—C03_2. http://dx.doi.org/10.1299/jsmermd.2010._1a2-c03_1.

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YOSHIZAKI, Wataru, et Satoshi KAGAMI. « 2P1-C03 AR control system for humanoid robot ». Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2010 (2010) : _2P1—C03_1—_2P1—C03_4. http://dx.doi.org/10.1299/jsmermd.2010._2p1-c03_1.

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SAGAE, Shuta, Yuki UEDA et Atsushi AKISAWA. « C03 Motion analysis of vibration type steam engine ». Proceedings of the Symposium on Stirlling Cycle 2014.17 (2014) : 61–62. http://dx.doi.org/10.1299/jsmessc.2014.17.61.

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Fenner, H. « Differentielle C0X-2/C0X-1-Hemmung und Nutzen-Risiko-Bewertung von nicht-steroidalen Antirheumatika (NSAR) : Neue Antworten auf alte Fragen ? » Aktuelle Rheumatologie 23, no 02 (mars 1998) : 29–34. http://dx.doi.org/10.1055/s-2008-1043577.

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Fenner, H. « Differentielle C0X-2/C0X-1-Hemmung und Nutzen-Risiko-Bewertung von nicht-steroidalen Antirheumatika (NSAR) : Neue Antworten auf alte Fragen ? » Aktuelle Rheumatologie 23, no 03 (mai 1998) : 83. http://dx.doi.org/10.1055/s-2008-1043587.

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RAMOS, F. « C035 Pulse pressure and left ventricular mass in ?non-dippers ? and ?peakers ? » American Journal of Hypertension 11, no 4 (avril 1998) : 56A. http://dx.doi.org/10.1016/s0895-7061(97)90910-9.

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Osberger, M. J., D. Burton Koch, L. Arnold et P. Boyle. « C035 Outcomes in young deaf children who received simultaneous bilateral cochlear implants ». International Journal of Pediatric Otorhinolaryngology 75 (mai 2011) : 39. http://dx.doi.org/10.1016/s0165-5876(11)70203-8.

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SHIMIZU, Yohei, Masahiko YOSHINO et Akinori YAMANAKA. « C03 Cutting experiments of silicon using external hydrostatic pressur ». Proceedings of The Manufacturing & ; Machine Tool Conference 2010.8 (2010) : 155–56. http://dx.doi.org/10.1299/jsmemmt.2010.8.155.

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Okazakl, M., H. Ohmae, J. Takahashi, H. Kimura et M. Sakuda. « Insolubilized properties of UV-irradiated C03 apatite-collagen composites ». Biomaterials 11, no 8 (octobre 1990) : 568–72. http://dx.doi.org/10.1016/0142-9612(90)90080-a.

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Tajima, Noriaki, Shuuta Inari, Ryoutarou Sawai, Takashi Nishiyama, Masato Adachi et Hiroyuki Kawamoto. « C03 Performance of Electrostatic Shield for Charged Lunar Regolith ». Proceedings of the Space Engineering Conference 2014.23 (2014) : _C03–1_—_C03–4_. http://dx.doi.org/10.1299/jsmesec.2014.23._c03-1_.

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NAKANO, Taiga, Yoshihiro SHIRAKAWA, Naohiko SUGITA, Takashi UEDA, Yasuhiro TAMAKI et Mamoru MITSUISHI. « 1P1-C03 A Parallel Robot to Assist Retinal Surgery ». Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) 2008 (2008) : _1P1—C03_1—_1P1—C03_3. http://dx.doi.org/10.1299/jsmermd.2008._1p1-c03_1.

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SHIOMI, Daiki, Masahiro OTA, Toshio OTAKA et Hiroshi SEKITANI. « C03 Pressure loss at kind of matrix of regenerator ». Proceedings of the Symposium on Stirlling Cycle 2001.5 (2001) : 107–10. http://dx.doi.org/10.1299/jsmessc.2001.5.107.

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USHIJIMA, Yoh, Kazuhiro HAMAGUCHI et Yoshikatsu HIRATSUKA. « C03 Basic characteristics of pulse tube engine (3^ Report) ». Proceedings of the Symposium on Stirlling Cycle 2006.10 (2006) : 35–38. http://dx.doi.org/10.1299/jsmessc.2006.10.35.

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Kawada, H., S. Saita, M. Takagi, Y. Shono et K. Tsushima. « C03 Behavior recording device using the optical passing sensor ». Medical Entomology and Zoology 54, supplement (2003) : 44. http://dx.doi.org/10.7601/mez.54.44_1.

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Hamy, Anne-Sophie, Amyn Kassara, Hamid Hocini, Clementine Garin, Luis Teixeira, Caroline Cuvier, Paul Gougis et al. « Abstract 3348 : Impact of comedications on pCR rates and relapse in breast cancer. Analysis of the Saint-Louis observational cohort ». Cancer Research 82, no 12_Supplement (15 juin 2022) : 3348. http://dx.doi.org/10.1158/1538-7445.am2022-3348.

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Abstract Context: There is a growing interest in drug repurposing and pathological complete response (pCR) that may influence the progression and treatment of breast cancer (BC). However, few studies focus on the influence of comedications, i.e., non-anticancerous drugs taken for coexisting conditions in cancer patients on neoadjuvant chemotherapy (NAC), and even less regarding the impact of response to treatment and relapse in breast cancer. Objectives: To assess whether the use of comedications modifies pCR and patient relapse probability in BC. Methods: We retrospectively analyzed data from Saint-Louis Hospital (Paris, France). Characteristics from 664 patients with neoadjuvant chemotherapy. Response to chemotherapy was assessed by pathological complete response (pCR). We analyzed comedication according to levels 1 and 2 of the Anatomical Therapeutic Chemical Classification System (ATC). A chronic comedication was defined by a comedication declared at diagnosis, excluding local and/or non-continuous administration. To estimate the average causal effect of comedication on pCR, we employed Inverse Probability Weighting (IPW) and Super Learner strategy to pick the best regression model. We used a Cox multivariate regression model to analyze the average causal effect of comedications on relapse probability. Results: 664 patients were included in this study. The median age at inclusion was 51.4 years. Of 664 patients, 194 patients (29.2%) had at least one comedication (433 total comedications). The repartition of comedications, according to the 1st level of ATC, was as follows: Cardiovascular system (C): 40.2% (n=174), Nervous system (N): 23.8% (n=103) and Alimentary tract and metabolism (A): 15.2% (n=66). Among the population with collected pCR, 112 tumors achieved pCR (18.6%). After IPW adjusted for clinical, pathological, and treatment variables, C03 (Diuretics) was associated with an increased likelihood of positive pCR (C03 versus no C03, OR = 5.0, CI95% [1.25-12.2]). By contrast, N06 (Psychoanaleptics) was associated with a decrease in pCR rates (OR= 0.3, CI95% [0.1-0.6]). The multivariate survival analysis showed a significant effect on the relapse probability of Selective Serotonin reuptake inhibitors (SSRIs, NO6) (OR = 2.3 CI95% [1.2-4.4], p = 0.01). Discussion: In this observational analysis, the use of chronic cardiovascular diuretics (C03) during NAC was associated with improvement of pCR rates. On the contrary, Psychoanaleptics (N06) were significantly associated with lower pCR rates and a higher probability of relapse. This finding prompts for further research on the interactions between chemotherapy, nervous system drugs such as SSRIs, and pathological complete response. Citation Format: Anne-Sophie Hamy, Amyn Kassara, Hamid Hocini, Clementine Garin, Luis Teixeira, Caroline Cuvier, Paul Gougis, Elise Dumas, Fabien Reyal, Beatriz Grandal, Nadir Sella, Eric Daoud, Aurélien Latouche, Thierry Dubois, Annabelle Ballesta, Samar Alsafadi, Elaine Del Nery, Élodie Anthony, Benjamin Marande, Cedric de Bazelaire, Anne de Roquancourt, Catherine Michel, Sylvie Giacchetti, Marc Espie. Impact of comedications on pCR rates and relapse in breast cancer. Analysis of the Saint-Louis observational cohort [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3348.
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Kraishan, G. M., et N. M. Lemont. « SIDERITE AS A CONSTRAINT ON DEPOSITIONAL AND EARLY DIAGENETIC HISTORY : EXAMPLES FROM BARROW SUB-BASIN, NORTH WEST SHELF, WESTERN AUSTRALIA ». APPEA Journal 38, no 1 (1998) : 238. http://dx.doi.org/10.1071/aj97012.

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Siderite cement is one of the most volumetrically important diagenetic minerals in the Late Triassic to Early Cretaceous sandstones of the Barrow Sub-basin. It constitutes up to 60 per cent of the rock volume, and where abundant, occludes the primary intergranular porosity. Petrogriiphic, chemical and isotopic studies indicate the early precipitation of much of this siderite prior to significant compaction. Siderite samples and concretions were taken from a variety of depositional environments ranging from fluvial to deep marine from Late Triassic to Early Cretaceous sequences.Of the early phases, three distinct siderite types were recognised and vary according to depositional environment. The first type, mostly collected from fluvial deposits, is Fe-rich with a mean composition of (Fe96.3 Mg1.8 Ca0.9 Mn1.0) C03. The second type of siderite cement is relatively Mg-rich, Ca-poor and has a higher Mn content, with a mean composition of (Fe87.1 Mg9.6 Ca1.2 Mn2.1) C03. The third type of siderite cement is typically Mg−, Ca-rich, with a low Mn content and an average composition of (Fe78.7 Mg12.4 Ca8.4 Mn0.5) C03. The second and third siderite cements occur in marine facies. The δ13C and δ180 values for siderite cements range from −2.8 to −14.3 %. PDB and 17.4 to 28.2 %. SMOW, respectively.Petrographic and chemical isotopic studies and other sedimentological data from siderite can be used to distinguish between different depositional environments. Chemical and isotopic compositions of the early authigenic siderites indicate precipitation from fluids with significant meteoric input. Siderite cements formed during sulphate reduction and early methanogenesis from mixed marine and meteoric pore-waters at temperatures below 30°C. While an influx of meteoric water to the fluvial and deltaic sediments of the Triassic Mungaroo Formation is easily envisaged, the siderites show that some mixing of sea water is also required. The concept of introduction of meteoric water to the marine sediments of the Birdrong Formation requires an appreciation of the sea level fluctuations at the time. In these situations, the recognition of meteoric or marine input to an early siderite cement can assist in the determination of sea level fluctuations.
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SEGERS, P. « C039 A generalised pressure transfer function between central and upper limb arterial pressure ». American Journal of Hypertension 11, no 4 (avril 1998) : 57A. http://dx.doi.org/10.1016/s0895-7061(97)90914-6.

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