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Littérature scientifique sur le sujet « Breathomics »

Auteur : Grafiati

Publié le 10 mars 2023

Mis à jour le 11 mars 2023

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Articles de revues sur le sujet "Breathomics"

van der Schee, Marc Philippe, Tamara Paff, Paul Brinkman, Willem Marinus Christiaan van Aalderen, Eric Gerardus Haarman et Peter Jan Sterk. « Breathomics in Lung Disease ». Chest 147, n^o 1 (janvier 2015) : 224–31. http://dx.doi.org/10.1378/chest.14-0781.

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Zolkipli-Cunningham, Zarazuela, Jane C. Naviaux, Tomohiro Nakayama, Charlotte M. Hirsch, Jonathan M. Monk, Kefeng Li, Lin Wang et al. « Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder ». PLOS ONE 16, n^o 3 (18 mars 2021) : e0248771. http://dx.doi.org/10.1371/journal.pone.0248771.

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Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD). The current study in mice was conducted to characterize the bioenergetic, metabolomic, breathomic, and behavioral features of acute hyperpurinergia triggered by systemic injection of the purinergic agonist and danger signal, extracellular ATP (eATP). Responses were studied in C57BL/6J mice in the maternal immune activation (MIA) model and controls. Basal metabolic rates and locomotor activity were measured in CLAMS cages. Plasma metabolomics measured 401 metabolites. Breathomics measured 98 volatile organic compounds. Intraperitoneal eATP dropped basal metabolic rate measured by whole body oxygen consumption by 74% ± 6% (mean ± SEM) and rectal temperature by 6.2˚ ± 0.3˚C in 30 minutes. Over 200 metabolites from 37 different biochemical pathways where changed. Breathomics showed an increase in exhaled carbon monoxide, dimethylsulfide, and isoprene. Metabolomics revealed an acute increase in lactate, citrate, purines, urea, dopamine, eicosanoids, microbiome metabolites, oxidized glutathione, thiamine, niacinamide, and pyridoxic acid, and decreased folate-methylation-1-carbon intermediates, amino acids, short and medium chain acyl-carnitines, phospholipids, ceramides, sphingomyelins, cholesterol, bile acids, and vitamin D similar to some children with ASD. MIA animals were hypersensitive to postnatal exposure to eATP or poly(IC), which produced a rebound increase in body temperature that lasted several weeks before returning to baseline. Acute hyperpurinergia produced metabolic and behavioral changes in mice. The behaviors and metabolic changes produced by ATP injection were associated with mitochondrial functional changes that were profound but reversible.

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Peel, Adam M., Yoon K. Loke et Andrew M. Wilson. « Asthma Breathomics and Biomedium Consideration ». Chest 153, n^o 5 (mai 2018) : 1283. http://dx.doi.org/10.1016/j.chest.2018.02.029.

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Drera, Giovanni, Sonia Freddi, Aleksei V. Emelianov, Ivan I. Bobrinetskiy, Maria Chiesa, Michele Zanotti, Stefania Pagliara et al. « Exploring the performance of a functionalized CNT-based sensor array for breathomics through clustering and classification algorithms : from gas sensing of selective biomarkers to discrimination of chronic obstructive pulmonary disease ». RSC Advances 11, n^o 48 (2021) : 30270–82. http://dx.doi.org/10.1039/d1ra03337a.

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Kistenev, Yury, Alexey Borisov, Victor Nikolaev, Denis Vrazhnov et Dmytry Kuzmin. « Laser photoacoustic spectroscopy applications in breathomics ». Journal of Biomedical Photonics & ; Engineering 5, n^o 1 (28 mars 2019) : 010303. http://dx.doi.org/10.18287/jbpe19.05.010303.

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Freddi, Sonia, Camilla Marzuoli, Stefania Pagliara, Giovanni Drera et Luigi Sangaletti. « Targeting biomarkers in the gas phase through a chemoresistive electronic nose based on graphene functionalized with metal phthalocyanines ». RSC Advances 13, n^o 1 (2023) : 251–63. http://dx.doi.org/10.1039/d2ra07607a.

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An electronic nose based on graphene chemiresistor sensors functionalized with phthalocyanines has been developed to detect selected biomarkers in the gas phase for breathomics, environmental monitoring, and food control applications.

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Ivan, Ignatius, Ignatius Ivan, Maureen Miracle Stella, Maureen Miracle Stella, Kevin Tandarto, Kevin Tandarto, Fanny Budiman, Fanny Budiman, Freggy Spicano Joprang et Freggy Spicano Joprang. « Plasmodium falciparum Breath Metabolomics (Breathomics) Analysis as a Non-Invasive Practical Method to Diagnose Malaria in Pediatric ». Indonesian Journal of Tropical and Infectious Disease 9, n^o 1 (27 avril 2021) : 24. http://dx.doi.org/10.20473/ijtid.v9i1.24069.

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Children under 5 years of age are particularly vulnerable to malaria. Malaria has caused 445,000 deaths worldwide. Currently, rapid diagnostic tests (RDTs) are the fastest method to diagnose malaria. However, there are limitations that exist such as low sensitivity in detecting infections with low parasitemia. Practical, non-invasive and high ability tests to detect parasite are needed to find specific biomarkers for P. falciparum infection to determine the potential of P. falciparum 4 thioether in breathomics analysis by GC-MS as a practical non-invasive method in diagnosing malaria in pediatrics. Literature reviews from Google Scholar and ProQuest were published no later than the last 5 years. The concept of breathomics is that the breath’s volatile organic compounds (VOCs) profile is altered when the health condition changes. Breath samples from individuals infected with P. falciparum malaria were taken by exhalation. Through GC-MS analysis, it was found that 4 thioether compounds (allyl methyl sulfide (AMS), 1-methylthio-propane, (Z) -1-methylthio-1-propene and (E) -1-methylthio-1-propene) underwent a significant change in concentration during the infection. Based on experiments conducted on mice and humans, the breathomics method is known to be able to detect parasitemia levels up to <100 parasites/µL, has a sensitivity level of about 71% to 91% and a specificity of about 75% to 94%. The discovery of 4 thioether compounds by GC-MS is a strong indication of malaria, because it has the potential for high sensitivity and specificity, and the detection power exceeds the ability of RDTs.

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Azim, Adnan, Clair Barber, Paddy Dennison, John Riley et Peter Howarth. « Exhaled volatile organic compounds in adult asthma : a systematic review ». European Respiratory Journal 54, n^o 3 (4 juillet 2019) : 1900056. http://dx.doi.org/10.1183/13993003.00056-2019.

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The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds (VOCs). Given the number of studies reporting “breathomics” findings and its growing integration in clinical trials, we performed a systematic review of the literature to summarise current evidence and understanding of breathomics technology in asthma.A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-oriented systematic search was performed (CRD42017084145) of MEDLINE, Embase and the Cochrane databases to search for any reports that assessed exhaled VOCs in adult asthma patients, using the following terms (asthma AND (volatile organic compounds AND exhaled) OR breathomics).Two authors independently determined the eligibility of 2957 unique records, of which 66 underwent full-text review. Data extraction and risk of bias assessment was performed on the 22 studies deemed to fulfil the search criteria. The studies are described in terms of methodology and the evidence narratively summarised under the following clinical headings: diagnostics, phenotyping, treatment stratification, treatment monitoring and exacerbation prediction/assessment.Our review found that most studies were designed to assess diagnostic potential rather than focus on underlying biology or treatable traits. Results are generally limited by a lack of methodological standardisation and external validation and by insufficiently powered studies, but there is consistency across the literature that exhaled VOCs are sensitive to underlying inflammation. Modern studies are applying robust breath analysis workflows to large multi-centre study designs, which should unlock the full potential of measurement of exhaled volatile organic compounds in airways diseases such as asthma.

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Brinkman, Paul, Anke-Hilse Maitland-van der Zee et Ariane H. Wagener. « Breathomics and treatable traits for chronic airway diseases ». Current Opinion in Pulmonary Medicine 25, n^o 1 (janvier 2019) : 94–100. http://dx.doi.org/10.1097/mcp.0000000000000534.

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Ferraro, Valentina Agnese, Silvia Carraro, Paola Pirillo, Antonina Gucciardi, Gabriele Poloniato, Matteo Stocchero, Giuseppe Giordano, Stefania Zanconato et Eugenio Baraldi. « Breathomics in Asthmatic Children Treated with Inhaled Corticosteroids ». Metabolites 10, n^o 10 (29 septembre 2020) : 390. http://dx.doi.org/10.3390/metabo10100390.

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Background: “breathomics” enables indirect analysis of metabolic patterns underlying a respiratory disease. In this study, we analyze exhaled breath condensate (EBC) in asthmatic children before (T0) and after (T1) a three-week course of inhaled beclomethasone dipropionate (BDP). Methods: we recruited steroid-naive asthmatic children for whom inhaled steroids were indicated and healthy children, evaluating asthma control, spirometry and EBC (in asthmatics at T0 and T1). A liquid-chromatography–mass-spectrometry untargeted analysis was applied to EBC and a mass spectrometry-based target analysis to urine samples. Results: metabolomic analysis discriminated asthmatic (n = 26) from healthy children (n = 16) at T0 and T1, discovering 108 and 65 features relevant for the discrimination, respectively. Searching metabolomics databases, seven putative biomarkers with a plausible role in asthma biochemical–metabolic processes were found. After BDP treatment, asthmatic children, in the face of an improved asthma control (p < 0.001) and lung function (p = 0.01), showed neither changes in EBC metabolomic profile nor in urinary endogenous steroid profile. Conclusions: “breathomics” can discriminate asthmatic from healthy children, with prostaglandin, fatty acid and glycerophospholipid as putative markers. The three-week course of BDP—in spite of a significant clinical improvement—was not associated with changes in EBC metabolic arrangement and urinary steroid profile.

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Thèses sur le sujet "Breathomics"

FREDDI, SONIA. « Sviluppo di piattaforme a base di carbonio nanostrutturato per applicazioni avanzate di gas sensing ». Doctoral thesis, Università Cattolica del Sacro Cuore, 2022. http://hdl.handle.net/10280/117007.

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Tra le applicazioni all'avanguardia di materiali a base di carbonio nanostrutturato, come grafene e nanotubi di carbonio (CNTs), l'analisi del respiro (i.e. breathomics), il monitoraggio ambientale e l'industria alimentare stanno oggigiorno sfidando la fisica, la chimica e l’ingegneria dei materiali a sviluppare piattaforme di sensori estremamente sensibili, affidabili e stabili, che siano in grado di rilevare piccolissime quantità (ordine dei ppb) di molecole di gas nell’ambiente che le circonda. In questa tesi, verrà presentato lo sviluppo di 6 piattaforme di sensori di gas. Queste piattaforme saranno sviluppate con carbonio nanostrutturato e avranno come scopo principale quello di discriminare potenziali patologie attraverso il riconoscimento di pattern molecolari presenti nel respiro esalato, nonché la loro possibile applicazione nel monitoraggio ambientale degli inquinanti e nell’industria alimentare. Questo obbiettivo verrà realizzato sviluppando dapprima piattaforme a base di CNTs su un substrato di plastica o su silicio/ossido di silicio e successivamente a base di grafene su nitruro di silicio. Verranno esplorati diversi metodi di funzionalizzazione sia per i CNTs che per il grafene, per aumentarne la sensitività, e verranno utilizzati diversi materiali per la funzionalizzazione, incluse nanoparticelle, molecole organiche o sali di diazonio. Tecniche di spettroscopie Raman ed elettroniche unitamente a microscopia a forza atomica verranno utilizzare per caratterizzare i campioni, mentre le esposizioni di gas verranno effettuate in aria, condizione più simile a quella delle applicazioni finali dei sensori, cercando di indagare concentrazioni dei gas selezionati nel sub-ppm o di poche decine di ppm. L’analisi delle componenti principali (PCA) verrà utilizzata per testare le capacità di discriminazione dei gas delle piattaforme sviluppate. Infine, uno dei nasi elettronici sviluppati verrà testato con il respiro esalato di soggetti sani o affetti da broncopneumopatie cronico ostruttive (COPD), dimostrando un’ottima capacità di discriminare e riconoscere le due classi di pazienti.
Among forefront applications of nanostructured carbon materials such as graphene and nanotubes, breathomics, environmental monitoring and food industry are challenging physics, chemistry and device engineering to develop extremely sensitive, selective, and stable platform to recognize ppb amount of target molecules in the environment. In this thesis, the development of 6 platforms will be presented. The platforms are based on nanostructured carbon aimed mostly to discriminate potential pathologies through pattern recognition in molecular fingerprint of breath samples, but also for environmental monitoring or food industry applications. This objective will be realized through properly developed devices based first on CNTs on a plastic substrate or on silicon/silicon oxide substrate and then on graphene on silicon nitride. Different kinds of functionalization techniques of graphene and CNTs will be explored to enhance the sensitivity of the pristine layers, as well as different functionalization materials, going from nanoparticles to organic molecules or diazonium salt precursors. The characterization of the materials involves electron and Raman spectroscopies, as well as atomic force microscopy, while gas exposures are carried out in the lab environment, which is much closer to the destination of the developed sensors, trying to investigate a low-ppm range or sub-ppm range of the considered gases. The gas discrimination is assessed through principal component analysis (PCA). Finally, one of the developed devices is exposed to the exhaled breath of healthy subjects or patients affected by chronic obstructive pulmonary diseases (COPD), demonstrating a remarkable capability to discriminate between healthy and sick patients.

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Rufo, João Pedro Cavaleiro. « Paediatric asthma : from environmental determinants towards diagnostic breathomics ». Doctoral thesis, 2018. https://hdl.handle.net/10216/112357.

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Rufo, João Pedro Cavaleiro. « Paediatric asthma : from environmental determinants towards diagnostic breathomics ». Tese, 2018. https://hdl.handle.net/10216/112357.

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Chapitres de livres sur le sujet "Breathomics"

Kistenev, Yury V., Alexey V. Borisov et Denis A. Vrazhnov. « Breathomics for Lung Cancer Diagnosis ». Dans Multimodal Optical Diagnostics of Cancer, 209–43. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44594-2_6.

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Beale, David J., Oliver A. H. Jones, Avinash V. Karpe, Ding Y. Oh, Iain R. White, Konstantinos A. Kouremenos et Enzo A. Palombo. « Breathomics and its Application for Disease Diagnosis : A Review of Analytical Techniques and Approaches ». Dans Volatile organic compound analysis in biomedical diagnosis applications, 159–94. Toronto ; New Jersey : Apple Academic Press, 2019. : Apple Academic Press, 2018. http://dx.doi.org/10.1201/9780429433580-7.

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Lammers, A., J. J. M. H. van Bragt, P. Brinkman, A. H. Neerincx, L. D. Bos, S. J. H. Vijverberg et A. H. Maitland-van der Zee. « Breathomics in Chronic Airway Diseases ». Dans Systems Medicine, 244–55. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-801238-3.11589-2.

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Actes de conférences sur le sujet "Breathomics"

Lüno, M., G. Meyer-Lotz, C. Metzger, D. Gescher, C. Hoeschen, L. Gbauoui et T. Frodl. « Breathomics for depressive disorders ». Dans Abstracts of the 2nd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402998.

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Fens, Niki, Renée A. Douma, Peter J. Sterk et Pieter W. Kamphuisen. « Breathomics As A Diagnostic Tool For Pulmonary Embolism ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2678.

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Santini, Giuseppe, Stefano Di Carlo, Alfredo Benso, Nadia Mores, Paul Brinkman, Salvatore Valente, Paolo Montuschi et al. « Breathomics can discriminate between anti IgE-treated and non-treated severe asthma adults ». Dans Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa1463.

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Fens, Niki, Annelot G. van Rossum, Pieter Zanen, Bram van Ginneken, Rob J. van Klaveren, Aeilko H. Zwinderman et Peter J. Sterk. « Cluster Analysis Identifies COPD Subphenotypes By Combining Pulmonary Function, CT Imaging And Breathomics ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1009.

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Pattnaik, Bijay, Rohit Vadala, Sunil Bangaru, Naveen Bhatraju, Jaya Tak, Divyanjali Rai, Seetu Kashyap et al. « Application of breathomics in early detection of lung cancer in indian population : a pilot study ». Dans ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.oa4316.

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Peel, AM, A. Sinha, YK Loke, AM Wilson, M. Wilkinson et SJ Fowler. « P12 Asthma breathomics – a systematic review of exhaled volatile organic compounds associated with diagnosis and disease characteristics ». Dans British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2019. http://dx.doi.org/10.1136/thorax-2019-btsabstracts2019.155.

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