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Articles de revues sur le sujet « Biosensing tool »

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Auteur : Grafiati
Publié le 11 mars 2023

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1

Sharma, Diksha, et Neeraj Tripathi. « Microcantilever : An Efficient Tool for Biosensing Applications ». International Journal of Intelligent Systems and Applications 9, no 10 (8 octobre 2017) : 63–74. http://dx.doi.org/10.5815/ijisa.2017.10.08.

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Huang, Tianci, Qi Yu, Shujuan Liu, Wei Huang et Qiang Zhao. « Phosphorescent iridium(iii) complexes : a versatile tool for biosensing and photodynamic therapy ». Dalton Transactions 47, no 23 (2018) : 7628–33. http://dx.doi.org/10.1039/c8dt00887f.

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Huang, Qiong, et Ling Dang. « Graphene-labeled synthetic antigen as a novel probe for enhancing sensitivity and simplicity in lateral flow immunoassay ». Analytical Methods 14, no 11 (2022) : 1155–62. http://dx.doi.org/10.1039/d1ay02158c.

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González-Pedro, Victoria, Mauricio E. Calvo, Hernán Míguez et Ángel Maquieira. « Nanoparticle Bragg reflectors : A smart analytical tool for biosensing ». Biosensors and Bioelectronics : X 1 (juin 2019) : 100012. http://dx.doi.org/10.1016/j.biosx.2019.100012.

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Graves, Jennifer S., et Xavier Montalban. « Biosensors to monitor MS activity ». Multiple Sclerosis Journal 26, no 5 (22 janvier 2020) : 605–8. http://dx.doi.org/10.1177/1352458519888178.

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Advances in wearable and wireless biosensing technology pave the way for a brave new world of novel multiple sclerosis (MS) outcome measures. Our current tools for examining patients date back to the 19th century and while invaluable to the neurologist invite accompaniment from these new technologies and artificial intelligence (AI) analytical methods. While the most common biosensor tool used in MS publications to date is the accelerometer, the landscape is changing quickly with multi-sensor applications, electrodermal sensors, and wireless radiofrequency waves. Some caution is warranted to ensure novel outcomes have clear clinical relevance and stand-up to the rigors of reliability, reproducibility, and precision, but the ultimate implementation of biosensing in the MS clinical setting is inevitable.
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Alcanzare, Maria Michiko, Mikko Karttunen et Tapio Ala-Nissila. « Propulsion and controlled steering of magnetic nanohelices ». Soft Matter 15, no 7 (2019) : 1684–91. http://dx.doi.org/10.1039/c8sm00037a.

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Aguedo, Juvissan, Lenka Lorencova, Marek Barath, Pavol Farkas et Jan Tkac. « Electrochemical Impedance Spectroscopy on 2D Nanomaterial MXene Modified Interfaces : Application as a Characterization and Transducing Tool ». Chemosensors 8, no 4 (7 décembre 2020) : 127. http://dx.doi.org/10.3390/chemosensors8040127.

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This review presents the basic characteristics of MXene, a novel 2D nanomaterial with many outstanding properties applicable to electrochemical sensing and biosensing. The second part deals with electrochemical impedance spectroscopy (EIS) and its beneficial features applicable to ultrasensitive electrochemical sensing and label-free biosensing. The main part of the review presents recent advances in the integration of MXene to design electrochemical interfaces. EIS was used to evaluate the effect of anodic potential on MXene and the effect of the MXene preparation route and for characterization of MXene grafted with polymers. It also included the application of EIS as the main transducing tool for antibody- and aptamer-based biosensors or biosensors integrating molecularly imprinted polymers.
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Rodríguez-Sevilla, P., L. Labrador-Páez, D. Jaque et P. Haro-González. « Optical trapping for biosensing : materials and applications ». Journal of Materials Chemistry B 5, no 46 (2017) : 9085–101. http://dx.doi.org/10.1039/c7tb01921a.

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Optical trapping has been evidence as a very powerful tool for the manipulation and study of biological entities. This review explains the main concepts regarding the use of optical trapping for biosensing, focusing its attention to those applications involving the manipulation of particles which are used as handles, force transducers and sensors.
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Das, Gour Mohan, Stefano Managò, Maria Mangini et Anna Chiara De Luca. « Biosensing Using SERS Active Gold Nanostructures ». Nanomaterials 11, no 10 (12 octobre 2021) : 2679. http://dx.doi.org/10.3390/nano11102679.

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Surface-enhanced Raman spectroscopy (SERS) has become a powerful tool for biosensing applications owing to its fingerprint recognition, high sensitivity, multiplex detection, and biocompatibility. This review provides an overview of the most significant aspects of SERS for biomedical and biosensing applications. We first introduced the mechanisms at the basis of the SERS amplifications: electromagnetic and chemical enhancement. We then illustrated several types of substrates and fabrication methods, with a focus on gold-based nanostructures. We further analyzed the relevant factors for the characterization of the SERS sensor performances, including sensitivity, reproducibility, stability, sensor configuration (direct or indirect), and nanotoxicity. Finally, a representative selection of applications in the biomedical field is provided.
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Singh, Suchita, Aksha Dhawan, Sonali Karhana, Madhusudan Bhat et Amit Kumar Dinda. « Quantum Dots : An Emerging Tool for Point-of-Care Testing ». Micromachines 11, no 12 (29 novembre 2020) : 1058. http://dx.doi.org/10.3390/mi11121058.

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Quantum dots (QDs) are semiconductor crystals in the nanodimension having unique optical and electronic properties that differ from bulk material due to quantum mechanics. The QDs have a narrow emission peak, size-dependent emission wavelength, and broad excitation range which can be utilized for diverse biomedical applications such as molecular imaging, biosensing, and diagnostic systems. This article reviews the current developments of biomedical applications of QDs with special reference to point-of-care testing.
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Leitão, Cátia, Sónia O. Pereira, Carlos Marques, Nunzio Cennamo, Luigi Zeni, Madina Shaimerdenova, Takhmina Ayupova et Daniele Tosi. « Cost-Effective Fiber Optic Solutions for Biosensing ». Biosensors 12, no 8 (28 juillet 2022) : 575. http://dx.doi.org/10.3390/bios12080575.

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In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.
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Scognamiglio, Viviana, et Amina Antonacci. « Structural Changes as a Tool for Affinity Recognition : Conformational Switch Biosensing ». Crystals 12, no 9 (27 août 2022) : 1209. http://dx.doi.org/10.3390/cryst12091209.

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Biosensors draw inspiration from natural chemosensing based on molecular switches between different bond-induced conformational states. Proteins and nucleic acids can be adapted into switch-based biosensors with a wide plethora of different configurations, taking advantage of the variety of transduction systems, from optical to electrochemical or electrochemiluminescence, as well as from nanomaterials for signal augmentation. This review reports the latest trends in conformational switch biosensors reported in the literature in the last 10 years, focusing on the main representative and recent examples of protein-based switching biosensors, DNA nanomachines, and structure-switched aptamers being applied for the detection of a wide range of target analytes with interest in biomedical and agro-environmental sectors.
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Soylemez, Saniye. « A Conjugated Polymer and SWCNTs Transducer for an Effective Biosensing Tool ». Journal of The Electrochemical Society 166, no 10 (2019) : B853—B858. http://dx.doi.org/10.1149/2.0051912jes.

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Ryken, Jef, Jiaqi Li, Tim Steylaerts, Rita Vos, Josine Loo, Karolien Jans, Willem Van Roy et al. « Biosensing with SiO2-covered SPR substrates in a commercial SPR-tool ». Sensors and Actuators B : Chemical 200 (septembre 2014) : 167–72. http://dx.doi.org/10.1016/j.snb.2014.04.060.

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Lin, Xiaoxiao, Zhiguang Wang, Xuexia Jia, Ruipeng Chen, Yingkai Qin, Yalan Bian, Wei Sheng, Shuang Li et Zhixian Gao. « Stimulus-responsive hydrogels : A potent tool for biosensing in food safety ». Trends in Food Science & ; Technology 131 (janvier 2023) : 91–103. http://dx.doi.org/10.1016/j.tifs.2022.12.002.

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Malon, Radha S. P., Sahba Sadir, Malarvili Balakrishnan et Emma P. Córcoles. « Saliva-Based Biosensors : Noninvasive Monitoring Tool for Clinical Diagnostics ». BioMed Research International 2014 (2014) : 1–20. http://dx.doi.org/10.1155/2014/962903.

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Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.
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Sundaresan, Savita M., S. M. Fothergill, Tanveer A. Tabish, Mary Ryan et Fang Xie. « Aptamer biosensing based on metal enhanced fluorescence platform : A promising diagnostic tool ». Applied Physics Reviews 8, no 4 (décembre 2021) : 041311. http://dx.doi.org/10.1063/5.0065833.

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P J, Jandas, K. Prabakaran, Jingting Luo et Derry Holaday M G. « Effective utilization of quartz crystal microbalance as a tool for biosensing applications ». Sensors and Actuators A : Physical 331 (novembre 2021) : 113020. http://dx.doi.org/10.1016/j.sna.2021.113020.

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Mao, Zefeng, Ruipeng Chen, Xiaojuan Wang, Zixuan Zhou, Yuan Peng, Shuang Li, Dianpeng Han et al. « CRISPR/Cas12a-based technology : A powerful tool for biosensing in food safety ». Trends in Food Science & ; Technology 122 (avril 2022) : 211–22. http://dx.doi.org/10.1016/j.tifs.2022.02.030.

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Bi, Sai, Shuzhen Yue et Shusheng Zhang. « Hybridization chain reaction : a versatile molecular tool for biosensing, bioimaging, and biomedicine ». Chemical Society Reviews 46, no 14 (2017) : 4281–98. http://dx.doi.org/10.1039/c7cs00055c.

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21

Guo, Qiushi, Tao Kong, Ruigong Su, Qi Zhang et Guosheng Cheng. « Noise spectroscopy as an equilibrium analysis tool for highly sensitive electrical biosensing ». Applied Physics Letters 101, no 9 (27 août 2012) : 093704. http://dx.doi.org/10.1063/1.4748931.

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Baldrich, Eva, et Francesc X. Muñoz. « Carbon Nanotube Wiring : A Tool for Straightforward Electrochemical Biosensing at Magnetic Particles ». Analytical Chemistry 83, no 24 (15 décembre 2011) : 9244–50. http://dx.doi.org/10.1021/ac201137q.

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Komarova, E., K. Reber, M. Aldissi et A. Bogomolova. « New multispecific array as a tool for electrochemical impedance spectroscopy-based biosensing ». Biosensors and Bioelectronics 25, no 6 (février 2010) : 1389–94. http://dx.doi.org/10.1016/j.bios.2009.10.034.

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Tarnowska, Monika, et Tomasz Krawczyk. « Click chemistry as a tool in biosensing systems for sensitive copper detection ». Biosensors and Bioelectronics 169 (décembre 2020) : 112614. http://dx.doi.org/10.1016/j.bios.2020.112614.

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Grattieri, Matteo, Kamrul Hasan et Shelley D. Minteer. « Bioelectrochemical Systems as a Multipurpose Biosensing Tool : Present Perspective and Future Outlook ». ChemElectroChem 4, no 4 (16 novembre 2016) : 834–42. http://dx.doi.org/10.1002/celc.201600507.

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Martín-Yerga, Daniel. « Electrochemical Detection and Characterization of Nanoparticles with Printed Devices ». Biosensors 9, no 2 (28 mars 2019) : 47. http://dx.doi.org/10.3390/bios9020047.

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Innovative methods to achieve the user-friendly, quick, and highly sensitive detection of nanomaterials are urgently needed. Nanomaterials have increased importance in commercial products, and there are concerns about the potential risk that they entail for the environment. In addition, detection of nanomaterials can be a highly valuable tool in many applications, such as biosensing. Electrochemical methods using disposable, low-cost, printed electrodes provide excellent analytical performance for the detection of a wide set of nanomaterials. In this review, the foundations and latest advances of several electrochemical strategies for the detection of nanoparticles using cost-effective printed devices are introduced. These strategies will equip the experimentalist with an extensive toolbox for the detection of nanoparticles of different chemical nature and possible applications ranging from quality control to environmental analysis and biosensing.
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Mazlan, Nur-Fadhilah, Ling Ling Tan, Nurul Huda Abd Karim, Lee Yook Heng et Mohammad Imam Hasan Reza. « Optical biosensing using newly synthesized metal salphen complexes : A potential DNA diagnostic tool ». Sensors and Actuators B : Chemical 242 (avril 2017) : 176–88. http://dx.doi.org/10.1016/j.snb.2016.11.032.

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Zhu, Hengjia, Peng Liu, Lizhang Xu, Xin Li, Panwang Hu, Bangxiang Liu, Jianming Pan, Fu Yang et Xiangheng Niu. « Nanozyme-Participated Biosensing of Pesticides and Cholinesterases : A Critical Review ». Biosensors 11, no 10 (9 octobre 2021) : 382. http://dx.doi.org/10.3390/bios11100382.

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To improve the output and quality of agricultural products, pesticides are globally utilized as an efficient tool to protect crops from insects. However, given that most pesticides used are difficult to decompose, they inevitably remain in agricultural products and are further enriched into food chains and ecosystems, posing great threats to human health and the environment. Thus, developing efficient methods and tools to monitor pesticide residues and related biomarkers (acetylcholinesterase and butylcholinesterase) became quite significant. With the advantages of excellent stability, tailorable catalytic performance, low cost, and easy mass production, nanomaterials with enzyme-like properties (nanozymes) are extensively utilized in fields ranging from biomedicine to environmental remediation. Especially, with the catalytic nature to offer amplified signals for highly sensitive detection, nanozymes were finding potential applications in the sensing of various analytes, including pesticides and their biomarkers. To highlight the progress in this field, here the sensing principles of pesticides and cholinesterases based on nanozyme catalysis are definitively summarized, and emerging detection methods and technologies with the participation of nanozymes are critically discussed. Importantly, typical examples are introduced to reveal the promising use of nanozymes. Also, some challenges in the field and future trends are proposed, with the hope of inspiring more efforts to advance nanozyme-involved sensors for pesticides and cholinesterases.
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Ortiz-Riaño, Edwin J., Mariana D. Avila-Huerta, Diana L. Mancera-Zapata et Eden Morales-Narváez. « Quenching of Fluorescence Caused by Graphene Oxide as an Immunosensing Platform in a Microwell Plate Format ». Proceedings 60, no 1 (2 novembre 2020) : 60. http://dx.doi.org/10.3390/iecb2020-07017.

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Immunoassays are, at present, an important tool for diagnostics, drug development, and environmental monitoring. However, most immunoassays involve procedures that require many elements for their development. We introduce a novel biosensing platform based on fluorescence quenching caused by graphene oxide (GO) for the detection of Human-IgG and Prostate-Specific Antigen (PSA). We employ a single antibody for the capture and detection processes, avoiding washing steps. FITC fluorophore was conjugated with antibodies for H-IgG detection, whereas quantum dots were conjugated with antibodies for PSA detection. The simple biosensing platform consists of covering a 96-well microplate (with a polystyrene bottom) with GO. The graphene oxide adhesion is possible by way of electrostatic interactions between the plate surface modified with amino groups (positively charged) and the graphene oxide (negatively charged). This proposal showed an excellent response for the detection of Human-IgG, with acceptable precision (from 0.27% to 5%). The limit of detection reached for H-IgG was 3.35 ng mL-1. In the same manner, for PSA detection, the limit of detection reached was 0.02 ng mL-1 and the precision range was from 0.7% to 15.2%. Furthermore, this biosensing platform was demonstrated to operate with real samples of human urine doped with different concentrations of prostate-specific antigen.
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Heileman, Khalil, Jamal Daoud et Maryam Tabrizian. « Dielectric spectroscopy as a viable biosensing tool for cell and tissue characterization and analysis ». Biosensors and Bioelectronics 49 (novembre 2013) : 348–59. http://dx.doi.org/10.1016/j.bios.2013.04.017.

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Fiorito, Pablo A., Vinicius R. Gonçales, Eduardo A. Ponzio et Susana I. Córdoba de Torresi. « Synthesis, characterization and immobilization of Prussian blue nanoparticles. A potential tool for biosensing devices ». Chem. Commun., no 3 (2005) : 366–68. http://dx.doi.org/10.1039/b412583e.

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Piscitelli, Alessandra, Anna Pennacchio, Sara Longobardi, Raffaele Velotta et Paola Giardina. « Vmh2 hydrophobin as a tool for the development of “self-immobilizing” enzymes for biosensing ». Biotechnology and Bioengineering 114, no 1 (26 juillet 2016) : 46–52. http://dx.doi.org/10.1002/bit.26049.

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Xinyu, Bian, Fan Sun et Zhixuan Xu. « How Protein Labeling Applying ». E3S Web of Conferences 290 (2021) : 01020. http://dx.doi.org/10.1051/e3sconf/202129001020.

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In recent years, biosensing has played an irreplaceable position in scientific fields as well as our daily lives. A biosensor is an instrument that is sensitive to biological substances and converts its concentration into electrical signals for detection. It is an analysis tool or system composed of immobilized biologically sensitive materials as identification elements, appropriate physical and chemical transducers and signal amplification devices, and it has the functions of both a receiver and a converter. Pregnancy test sticks, blood glucose testing, etc. in life are all potential biosensors. The main point of this paper is to introduce several main techniques of biosensing for better understanding, like ELISA, fusion proteins, fluorescent probe and others. In the future, the bright future for them is also worth looking forward to if more researches and experiments can be processed in this area, for example, in the detection and treatment of cancer, medical technology can be further improved.
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Azam, Tehmina, Syed Hassan Bukhari, Usman Liaqat et Waheed Miran. « Emerging Methods in Biosensing of Immunoglobin G—A Review ». Sensors 23, no 2 (6 janvier 2023) : 676. http://dx.doi.org/10.3390/s23020676.

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Human antibodies are produced due to the activation of immune system components upon exposure to an external agent or antigen. Human antibody G, or immunoglobin G (IgG), accounts for 75% of total serum antibody content. IgG controls several infections by eradicating disease-causing pathogens from the body through complementary interactions with toxins. Additionally, IgG is an important diagnostic tool for certain pathological conditions, such as autoimmune hepatitis, hepatitis B virus (HBV), chickenpox and MMR (measles, mumps, and rubella), and coronavirus-induced disease 19 (COVID-19). As an important biomarker, IgG has sparked interest in conducting research to produce robust, sensitive, selective, and economical biosensors for its detection. To date, researchers have used different strategies and explored various materials from macro- to nanoscale to be used in IgG biosensing. In this review, emerging biosensors for IgG detection have been reviewed along with their detection limits, especially electrochemical biosensors that, when coupled with nanomaterials, can help to achieve the characteristics of a reliable IgG biosensor. Furthermore, this review can assist scientists in developing strategies for future research not only for IgG biosensors but also for the development of other biosensing systems for diverse targets.
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Campuzano, Susana, Paloma Yáñez-Sedeño et José Manuel Pingarrón. « Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases ». Sensors 21, no 1 (30 décembre 2020) : 189. http://dx.doi.org/10.3390/s21010189.

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The multifaceted key roles of cytokines in immunity and inflammatory processes have led to a high clinical interest for the determination of these biomolecules to be used as a tool in the diagnosis, prognosis, monitoring and treatment of several diseases of great current relevance (autoimmune, neurodegenerative, cardiac, viral and cancer diseases, hypercholesterolemia and diabetes). Therefore, the rapid and accurate determination of cytokine biomarkers in body fluids, cells and tissues has attracted considerable attention. However, many currently available techniques used for this purpose, although sensitive and selective, require expensive equipment and advanced human skills and do not meet the demands of today’s clinic in terms of test time, simplicity and point-of-care applicability. In the course of ongoing pursuit of new analytical methodologies, electrochemical biosensing is steadily gaining ground as a strategy suitable to develop simple, low-cost methods, with the ability for multiplexed and multiomics determinations in a short time and requiring a small amount of sample. This review article puts forward electrochemical biosensing methods reported in the last five years for the determination of cytokines, summarizes recent developments and trends through a comprehensive discussion of selected strategies, and highlights the challenges to solve in this field. Considering the key role demonstrated in the last years by different materials (with nano or micrometric size and with or without magnetic properties), in the design of analytical performance-enhanced electrochemical biosensing strategies, special attention is paid to the methods exploiting these approaches.
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Lechuga, Yolanda, Gregoire Kandel, Jose Angel Miguel et Mar Martinez. « Development of an Automated Design Tool for FEM-Based Characterization of Solid and Hollow Microneedles ». Micromachines 14, no 1 (3 janvier 2023) : 133. http://dx.doi.org/10.3390/mi14010133.

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Microneedle design for biomedical applications, such as transdermal drug delivery, vaccination and transdermal biosensing, has lately become a rapidly growing research field. In this sense, finite element analysis has been extendedly used by microneedle designers to determine the most suitable structural parameters for their prototypes, and also to predict their mechanical response and efficiency during the insertion process. Although many proposals include computer-aided tools to build geometrical models for mechanical analysis, there is a lack of software utilities intended to automate the design process encompassing geometrical modeling, simulation setup and postprocessing of results. This work proposes a novel MATLAB-based design tool for microneedle arrays that permits personalized selection of the basic characteristics of a mechanical model. The tool automatically exports the selected options to an ANSYS batch file, including instructions to run a static and a linear buckling analysis. Later, the subsequent simulation results can be retrieved for on-screen display and potential postprocessing. In addition, this work reviews recent proposals (2018–2022) about finite element model characterization of microneedles to establish the minimum set of features that any tool intended for automating a design process should provide.
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Ma, Jianbo, Peng Cai, Wei Qi, Desheng Kong et Hua Wang. « The layer-by-layer assembly of polyelectrolyte functionalized graphene sheets : A potential tool for biosensing ». Colloids and Surfaces A : Physicochemical and Engineering Aspects 426 (juin 2013) : 6–11. http://dx.doi.org/10.1016/j.colsurfa.2013.02.039.

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Deng, Jinan, Dandan Han et Jun Yang. « Applications of Microfluidics in Liquid Crystal-Based Biosensors ». Biosensors 11, no 10 (12 octobre 2021) : 385. http://dx.doi.org/10.3390/bios11100385.

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Liquid crystals (LCs) with stimuli-responsive configuration transition and optical anisotropic properties have attracted enormous interest in the development of simple and label-free biosensors. The combination of microfluidics and the LCs offers great advantages over traditional LC-based biosensors including small sample consumption, fast analysis and low cost. Moreover, microfluidic techniques provide a promising tool to fabricate uniform and reproducible LC-based sensing platforms. In this review, we emphasize the recent development of microfluidics in the fabrication and integration of LC-based biosensors, including LC planar sensing platforms and LC droplets. Fabrication and integration of LC-based planar platforms with microfluidics for biosensing applications are first introduced. The generation and entrapment of monodisperse LC droplets with different microfluidic structures, as well as their applications in the detection of chemical and biological species, are then summarized. Finally, the challenges and future perspectives of the development of LC-based microfluidic biosensors are proposed. This review will promote the understanding of microfluidic techniques in LC-based biosensors and facilitate the development of LC-based microfluidic biosensing devices with high performance.
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Franco, Jefferson Honorio, Shelley D. Minteer et Adalgisa R. De Andrade. « Ethanol Biofuel Cells : Hybrid Catalytic Cascades as a Tool for Biosensor Devices ». Biosensors 11, no 2 (4 février 2021) : 41. http://dx.doi.org/10.3390/bios11020041.

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Biofuel cells use chemical reactions and biological catalysts (enzymes or microorganisms) to produce electrical energy, providing clean and renewable energy. Enzymatic biofuel cells (EBFCs) have promising characteristics and potential applications as an alternative energy source for low-power electronic devices. Over the last decade, researchers have focused on enhancing the electrocatalytic activity of biosystems and on increasing energy generation and electronic conductivity. Self-powered biosensors can use EBFCs while eliminating the need for an external power source. This review details improvements in EBFC and catalyst arrangements that will help to achieve complete substrate oxidation and to increase the number of collected electrons. It also describes how analytical techniques can be employed to follow the intermediates between the enzymes within the enzymatic cascade. We aim to demonstrate how a high-performance self-powered sensor design based on EBFCs developed for ethanol detection can be adapted and implemented in power devices for biosensing applications.
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Kim, Seong-Eun, My Van Tieu, Sei Young Hwang et Min-Ho Lee. « Magnetic Particles : Their Applications from Sample Preparations to Biosensing Platforms ». Micromachines 11, no 3 (13 mars 2020) : 302. http://dx.doi.org/10.3390/mi11030302.

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The growing interest in magnetic materials as a universal tool has been shown by an increasing number of scientific publications regarding magnetic materials and its various applications. Substantial progress has been recently made on the synthesis of magnetic iron oxide particles in terms of size, chemical composition, and surface chemistry. In addition, surface layers of polymers, silica, biomolecules, etc., on magnetic particles, can be modified to obtain affinity to target molecules. The developed magnetic iron oxide particles have been significantly utilized for diagnostic applications, such as sample preparations and biosensing platforms, leading to the selectivity and sensitivity against target molecules and the ease of use in the sensing systems. For the process of sample preparations, the magnetic particles do assist in target isolation from biological environments, having non-specific molecules and undesired molecules. Moreover, the magnetic particles can be easily applied for various methods of biosensing devices, such as optical, electrochemical, and magnetic phenomena-based methods, and also any methods combined with microfluidic systems. Here we review the utilization of magnetic materials in the isolation/preconcentration of various molecules and cells, and their use in various techniques for diagnostic biosensors that may greatly contribute to future innovation in point-of-care and high-throughput automation systems.
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Sarcina, Lucia, Luisa Torsi, Rosaria Anna Picca, Kyriaki Manoli et Eleonora Macchia. « Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms ». Sensors 20, no 13 (30 juin 2020) : 3678. http://dx.doi.org/10.3390/s20133678.

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The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarkers are normally quantified from the same biological sample simultaneously. Therefore, it is critically important to translate lab-based bioelectronic devices based on electrolyte gated thin-film transistor technology into a cost-effective portable multiplexing array prototype. In this perspective, the assessment of cost-effective manufacturability represents a crucial step, with specific regard to the optimization of the bio-functionalization protocol of the transistor gate module. Hence, we have assessed, using surface plasmon resonance technique, a sustainable and reliable cost-effective process to successfully bio-functionalize a gold surface, suitable as gate electrode for wide-field bioelectronic sensors. The bio-functionalization process herein investigated allows to reduce the biorecognition element concentration to one-tenth, drastically impacting the manufacturing costs while retaining high analytical performance.
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Wang, Jing, Xifang Yang, Xueliang Wang et Wanhe Wang. « Recent Advances in CRISPR/Cas-Based Biosensors for Protein Detection ». Bioengineering 9, no 10 (28 septembre 2022) : 512. http://dx.doi.org/10.3390/bioengineering9100512.

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CRISPR is an acquired immune system found in prokaryotes that can accurately recognize and cleave foreign nucleic acids, and has been widely explored for gene editing and biosensing. In the past, CRISPR/Cas-based biosensors were mainly applied to detect nucleic acids in the field of biosensing, and their applications for the detection of other types of analytes were usually overlooked such as small molecules and disease-related proteins. The recent work shows that CRISPR/Cas biosensors not only provide a new tool for protein analysis, but also improve the sensitivity and specificity of protein detections. However, it lacks the latest review to summarize CRISPR/Cas-based biosensors for protein detection and elucidate their mechanisms of action, hindering the development of superior biosensors for proteins. In this review, we summarized CRISPR/Cas-based biosensors for protein detection based on their mechanism of action in three aspects: antibody-assisted CRISPR/Cas-based protein detection, aptamer-assisted CRISPR/Cas-based protein detection, and miscellaneous CRISPR/Cas-based methods for protein detection, respectively. Moreover, the prospects and challenges for CRISPR/Cas-based biosensors for protein detection are also discussed.
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Min, Hayeon, Sophie Zhu, Lydia Safi, Munzer Alkourdi, Bich Hong Nguyen, Akshaya Upadhyay et Simon D. Tran. « Salivary Diagnostics in Pediatrics and the Status of Saliva-Based Biosensors ». Biosensors 13, no 2 (30 janvier 2023) : 206. http://dx.doi.org/10.3390/bios13020206.

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Salivary biomarkers are increasingly being used as an alternative to diagnose and monitor the progression of various diseases due to their ease of use, on site application, non-invasiveness, and most likely improved patient compliance. Here, we highlight the role of salivary biosensors in the general population, followed by the application of saliva as a diagnostic tool in the pediatric population. We searched the literature for pediatric applications of salivary biomarkers, more specifically, in children from 0 to 18 years old. The use of those biomarkers spans autoimmune, developmental disorders, oncology, neuropsychiatry, respiratory illnesses, gastrointestinal disorders, and oral diseases. Four major applications of salivary proteins as biomarkers are: (1) dental health (caries, stress from orthodontic appliances, and gingivitis); (2) gastrointestinal conditions (eosinophilic esophagitis, acid reflux, appendicitis); (3) metabolic conditions (obesity, diabetes); and (4) respiratory conditions (asthma, allergic rhinitis, small airway inflammation, pneumonia). Genomics, metabolomics, microbiomics, proteomics, and transcriptomics, are various other classifications for biosensing based on the type of biomarkers used and reviewed here. Lastly, we describe the recent advances in pediatric biosensing applications using saliva. This work guides scientists in fabricating saliva-based biosensors by comprehensively overviewing the potential markers and techniques that can be employed.
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Manickam, Pandiaraj, Jayasudha Velayutham, Vignesh Magudeeswaran, Sriraja Subhasri Paramasivam et Gopi Karuppaiah. « Aptamer Functionalized Hydrogel Nanocomposite for Electrochemical Sensing of Progesterone ». ECS Transactions 107, no 1 (24 avril 2022) : 16369–74. http://dx.doi.org/10.1149/10701.16369ecst.

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Among the numerous analytical techniques, electrochemical devices have emerged as a cost-effective tool for point-of-care (POC) diagnosis. Electrochemical biosensing devices combine the peculiar features of the bioreceptors, such as selectivity and specificity, with a cost-effective and miniaturised electronic readout system. In this work, aptamer functionalised AuNCs integrated with a hybrid hydrogel employed as a reliable aptamer modified sensing platform for detecting progesterone (p4). The binding features of the p4 sensor are studied using square wave voltammetry. The p4 sensor was responsive to p4 concentration ranging from 1 to 100 nM with a detection limit of 0.3 ng/mL.
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Flores-Hernandez, Domingo R., Vivian J. Santamaria-Garcia, Elda M. Melchor-Martínez, Juan Eduardo Sosa-Hernández, Roberto Parra-Saldívar et Jaime Bonilla-Rios. « Paper and Other Fibrous Materials—A Complete Platform for Biosensing Applications ». Biosensors 11, no 5 (21 avril 2021) : 128. http://dx.doi.org/10.3390/bios11050128.

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Paper-based analytical devices (PADs) and Electrospun Fiber-Based Biosensors (EFBs) have aroused the interest of the academy and industry due to their affordability, sensitivity, ease of use, robustness, being equipment-free, and deliverability to end-users. These features make them suitable to face the need for point-of-care (POC) diagnostics, monitoring, environmental, and quality food control applications. Our work introduces new and experienced researchers in the field to a practical guide for fibrous-based biosensors fabrication with insight into the chemical and physical interaction of fibrous materials with a wide variety of materials for functionalization and biofunctionalization purposes. This research also allows readers to compare classical and novel materials, fabrication techniques, immobilization methods, signal transduction, and readout. Moreover, the examined classical and alternative mathematical models provide a powerful tool for bioanalytical device designing for the multiple steps required in biosensing platforms. Finally, we aimed this research to comprise the current state of PADs and EFBs research and their future direction to offer the reader a full insight on this topic.
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Yang, Yuan, Zhen Fang, Yang-Yang Yu, Yan-Zhai Wang, Saraschandra Naraginti et Yang-Chun Yong. « A mediator-free whole-cell electrochemical biosensing system for sensitive assessment of heavy metal toxicity in water ». Water Science and Technology 79, no 6 (15 mars 2019) : 1071–80. http://dx.doi.org/10.2166/wst.2019.101.

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Abstract A bioelectrochemical sensing system (BES) based on electroactive bacteria (EAB) has been used as a new and promising tool for water toxicity assessment. However, most EAB can reduce heavy metals, which usually results in low toxicity response. Herein, a starvation pre-incubation strategy was developed which successfully avoided the metal reduction during the toxicity sensing period. By integrating this starvation pre-incubation procedure with the amperometric BES, a sensitive, robust and mediator-free biosensing method for heavy metal toxicity assessment was developed. Under the optimized conditions, the IC50 (half maximal inhibitory concentration) values for Cu2+, Ni2+, Cd2+, and Cr6+ obtained were 0.35, 3.49, 6.52, 2.48 mg L−1, respectively. The measurement with real water samples also suggested this method was reliable for practical application. This work demonstrates that it is feasible to use EAB for heavy metal toxicity assessment and provides a new tool for water toxicity warning.
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Calderon, Irene, Luca Guerrini et Ramon A. Alvarez-Puebla. « Targets and Tools : Nucleic Acids for Surface-Enhanced Raman Spectroscopy ». Biosensors 11, no 7 (9 juillet 2021) : 230. http://dx.doi.org/10.3390/bios11070230.

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Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.
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Santhanam, Manikandan, Itay Algov et Lital Alfonta. « DNA/RNA Electrochemical Biosensing Devices a Future Replacement of PCR Methods for a Fast Epidemic Containment ». Sensors 20, no 16 (18 août 2020) : 4648. http://dx.doi.org/10.3390/s20164648.

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Pandemics require a fast and immediate response to contain potential infectious carriers. In the recent 2020 Covid-19 worldwide pandemic, authorities all around the world have failed to identify potential carriers and contain it on time. Hence, a rapid and very sensitive testing method is required. Current diagnostic tools, reverse transcription PCR (RT-PCR) and real-time PCR (qPCR), have its pitfalls for quick pandemic containment such as the requirement for specialized professionals and instrumentation. Versatile electrochemical DNA/RNA sensors are a promising technological alternative for PCR based diagnosis. In an electrochemical DNA sensor, a nucleic acid hybridization event is converted into a quantifiable electrochemical signal. A critical challenge of electrochemical DNA sensors is sensitive detection of a low copy number of DNA/RNA in samples such as is the case for early onset of a disease. Signal amplification approaches are an important tool to overcome this sensitivity issue. In this review, the authors discuss the most recent signal amplification strategies employed in the electrochemical DNA/RNA diagnosis of pathogens.
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Zhu, Zongwei, Hongqian Zhang, Xiaoxue Dong, Meng Lin et Chuanxu Yang. « Niosome-Assisted Delivery of DNA Fluorescent Probe with Optimized Strand Displacement for Intracellular MicroRNA21 Imaging ». Biosensors 12, no 8 (24 juillet 2022) : 557. http://dx.doi.org/10.3390/bios12080557.

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MicroRNAs play a vital role in cancer development and are considered as potential biomarkers for early prognostic assessment. Here, we propose a novel biosensing system to achieve fluorescence imaging of miRNA21 (miR21) in cancer cells. This system consists of two components: an optimized “off-on” double-stranded DNA (dsDNA) fluorescent for miR21 sensing by efficient strand-displacement reaction and a potent carrier vesicle, termed niosome (SPN), to facilitate the efficient intracellular delivery of the dsDNA probe. A series of dsDNA probes based on fluorescence energy resonance transfer (FRET) was assembled to target miR21. By optimizing the appropriate length of the reporter strand in the dsDNA probe, high accuracy and sensitivity for miR21 recognition are ensured. To overcome the cellular barrier, we synthesized SPN with the main components of a nonionic surfactant Span 80 and a cationic lipid DOTAP, which could efficiently load dsDNA probes via electrostatic interactions and potently deliver the dsDNA probes into cells with good biosafety. The SPN/dsDNA achieved efficient miR21 fluorescent imaging in living cells, and could discriminate cancer cells (MCF-7) from normal cells (L-02). Therefore, the proposed SPN/dsDNA system provides a powerful tool for intracellular miRNA biosensing, which holds great promise for early cancer diagnosis.
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Beeram, Reshma, Kameswara Rao Vepa et Venugopal Rao Soma. « Recent Trends in SERS-Based Plasmonic Sensors for Disease Diagnostics, Biomolecules Detection, and Machine Learning Techniques ». Biosensors 13, no 3 (27 février 2023) : 328. http://dx.doi.org/10.3390/bios13030328.

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Surface-enhanced Raman spectroscopy/scattering (SERS) has evolved into a popular tool for applications in biology and medicine owing to its ease-of-use, non-destructive, and label-free approach. Advances in plasmonics and instrumentation have enabled the realization of SERS’s full potential for the trace detection of biomolecules, disease diagnostics, and monitoring. We provide a brief review on the recent developments in the SERS technique for biosensing applications, with a particular focus on machine learning techniques used for the same. Initially, the article discusses the need for plasmonic sensors in biology and the advantage of SERS over existing techniques. In the later sections, the applications are organized as SERS-based biosensing for disease diagnosis focusing on cancer identification and respiratory diseases, including the recent SARS-CoV-2 detection. We then discuss progress in sensing microorganisms, such as bacteria, with a particular focus on plasmonic sensors for detecting biohazardous materials in view of homeland security. At the end of the article, we focus on machine learning techniques for the (a) identification, (b) classification, and (c) quantification in SERS for biology applications. The review covers the work from 2010 onwards, and the language is simplified to suit the needs of the interdisciplinary audience.
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