Littérature scientifique sur le sujet « Biometerial »

ABSTRAK Pemanfaatan biometerial sebagai bahan konstruksi jalan merupakan salah satu penelitian inovasi dalam mendukung pembangunan berkelanjutan pada sektor transportasi. Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan damar terhadap penetrasi aspal modifikai , dan untuk menemukan seberapa banyak penggunaan damar sebagai material substitusi aspal sehingga memenuhi persyaratan penetrasi sesuai ketentuan SNI. Persentase Damar yang digunakan sebagai bahan modifikasi antara 2.5%-10% terhadap berat total aspal modifikasi dengan interval 2,5%. Jenis damar yang digunkan adalah damar mata kucing dan aspal minyak yang digunakan adalah aspal pen 60/70. Pengujian penetrasi mengacu pada SNI 06-.2456-199. Alat yang digunakan adalah penetrometer. Hasil penelitian menunjukan bahwa nilai penertrasi aspal modifikasi pada kadar damar 2,5%, 5%, 7,5%, dan 10% secara berturut-turut adalah 65, 64, 63, 52, dan 48. Penggunaan Damar sebagai substitusi Aspal Minyak hingga 5,4% masih dalam rentang persyaratan spesifikasi yakni 60-70 (dmm). Kata Kunci : Damar, Aspal Pen 60/70, PenetrasiABSTRACT The use of biomaterials as a road construction material is one of the research innovations in supporting sustainable development in the transportation sector. This study aims to analyze the effect of the usage of damar on the penetration of modified asphalt, to find out how much damar which used as an asphalt substitution material that meets the penetration requirements according to the provisions of SNI, and to find the equation model of damar content and penetration relationship. The Damar content used as a modified material is between 0% -10% of the total weight of Modified Asphalt with an interval of 2.5%. The type of Damar used is Cat's Eye Damar, and the Petroleum Asphalt used is Penetration Asphalt - 60/70. The penetration testing uses a penetrometer and refers to SNI 06-.2456-199. The results showed that the penetration value of Modified Asphalt is 65, 64, 63, 52, and 48 mm by correspondings to Damar content of 0%, 2,5%, 5%, 7,5%, and 10%. The use of damar content up to 5,4% as a substitute for Petroleum Asphalt is still within the range of SNI specification requirements, namely 60-70 (0,1 mm). Keywords : Damar, Petroleum Asphalt, Penetration

2012 - 2013
This PhD project is focused on the development of new polymeric materials with antibacterial and antifungal activity. The first part of the work was dedicated to the synthesis and the insertion of a modified amino acid into an antimicrobial peptide (AMP), with the aim to retain the action mechanism on bacterial membranes. Understanding the mechanism of action of AMPs is important for the rational design of new drugs. For this reason, I have collected structural properties, antimicrobial activity values and biological origin of antimicrobial peptides from published data. I have calculated the most relevant chemical physical properties like charge, hydrophobic moment, helicity, flexibility, isoelectric point, Boman and instability index and penetration capabilities. This data collection work permitted us to create YADAMP (www.yadamp.unisa.it), a web database with detailed informations on AMPs. YADAMP database contains the highest number of active sequences with proven antimicrobial activity. YADAMP peremitted me to do a work of data mining that end up with the choice of a peptide, a defensine, to be used as template for developing a new photoresponsive peptide. The peptide, hereafter indicated as ALY, is a short α-helix, membrane active AMP with a tyrosine in the sequence. I have developed the modified analogue replacing the tyrosine by a modified tyrosine with azobenzene group in the side chain. The modified amino acid, named Fmoc-azoTyr, was synthesized according to the classic scheme of diazocopulation reactions. I have chosen the azobenzene group because it permits a reversible trans to cis photochemical isomerization... [edited by author]
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