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Littérature scientifique sur le sujet « Biomaterials, neural stem cell »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Biomaterials, neural stem cell"

Russell, Lauren N., et Kyle J. Lampe. « Engineering Biomaterials to Influence Oligodendroglial Growth, Maturation, and Myelin Production ». Cells Tissues Organs 202, n^o 1-2 (2016) : 85–101. http://dx.doi.org/10.1159/000446645.

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Millions of people suffer from damage or disease to the nervous system that results in a loss of myelin, such as through a spinal cord injury or multiple sclerosis. Diminished myelin levels lead to further cell death in which unmyelinated neurons die. In the central nervous system, a loss of myelin is especially detrimental because of its poor ability to regenerate. Cell therapies such as stem or precursor cell injection have been investigated as stem cells are able to grow and differentiate into the damaged cells; however, stem cell injection alone has been unsuccessful in many areas of neural regeneration. Therefore, researchers have begun exploring combined therapies with biomaterials that promote cell growth and differentiation while localizing cells in the injured area. The regrowth of myelinating oligodendrocytes from neural stem cells through a biomaterials approach may prove to be a beneficial strategy following the onset of demyelination. This article reviews recent advancements in biomaterial strategies for the differentiation of neural stem cells into oligodendrocytes, and presents new data indicating appropriate properties for oligodendrocyte precursor cell growth. In some cases, an increase in oligodendrocyte differentiation alongside neurons is further highlighted for functional improvements where the biomaterial was then tested for increased myelination both in vitro and in vivo.

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Little, Lauren, Kevin E. Healy et David Schaffer. « Engineering Biomaterials for Synthetic Neural Stem Cell Microenvironments ». Chemical Reviews 108, n^o 5 (mai 2008) : 1787–96. http://dx.doi.org/10.1021/cr078228t.

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Agbay, Andrew, John M. Edgar, Meghan Robinson, Tara Styan, Krista Wilson, Julian Schroll, Junghyuk Ko, Nima Khadem Mohtaram, Martin Byung-Guk Jun et Stephanie M. Willerth. « Biomaterial Strategies for Delivering Stem Cells as a Treatment for Spinal Cord Injury ». Cells Tissues Organs 202, n^o 1-2 (2016) : 42–51. http://dx.doi.org/10.1159/000446474.

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Ongoing clinical trials are evaluating the use of stem cells as a way to treat traumatic spinal cord injury (SCI). However, the inhibitory environment present in the injured spinal cord makes it challenging to achieve the survival of these cells along with desired differentiation into the appropriate phenotypes necessary to regain function. Transplanting stem cells along with an instructive biomaterial scaffold can increase cell survival and improve differentiation efficiency. This study reviews the literature discussing different types of instructive biomaterial scaffolds developed for transplanting stem cells into the injured spinal cord. We have chosen to focus specifically on biomaterial scaffolds that direct the differentiation of neural stem cells and pluripotent stem cells since they offer the most promise for producing the cell phenotypes that could restore function after SCI. In terms of biomaterial scaffolds, this article reviews the literature associated with using hydrogels made from natural biomaterials and electrospun scaffolds for differentiating stem cells into neural phenotypes. It then presents new data showing how these different types of scaffolds can be combined for neural tissue engineering applications and provides directions for future studies.

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Xia, Lin, Wenjuan Zhu, Yunfeng Wang, Shuangba He et Renjie Chai. « Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials ». Neural Plasticity 2019 (16 octobre 2019) : 1–11. http://dx.doi.org/10.1155/2019/3608386.

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The transplantation of neural stem cells (NSCs) has become an emerging treatment for neural degeneration. A key factor in such treatments is to manipulate NSC behaviors such as proliferation and differentiation, resulting in the eventual regulation of NSC fate. Novel bionanomaterials have shown usefulness in guiding the proliferation and differentiation of NSCs due to the materials’ unique morphological and topological properties. Among the nanomaterials, graphene has drawn increasing attention for neural regeneration applications based on the material’s excellent physicochemical properties, surface modifications, and biocompatibility. In this review, we summarize recent works on the use of graphene-based biomaterials for regulating NSC behaviors and the potential use of these materials in clinical treatment. We also discuss the limitations of graphene-based nanomaterials for use in clinical practice. Finally, we provide some future prospects for graphene-based biomaterial applications in neural regeneration.

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Finch, L., S. Harris, C. Adams, J. Sen, J. Tickle, N. Tzerakis et DM Chari. « WP1-22 DuraGen™ as an encapsulating material for neural stem cell delivery ». Journal of Neurology, Neurosurgery & ; Psychiatry 90, n^o 3 (14 février 2019) : e7.2-e7. http://dx.doi.org/10.1136/jnnp-2019-abn.22.

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ObjectivesAchieving neural regeneration after spinal cord injury (SCI) represents a significant challenge. Neural stem cell (NSC) therapy offers replacement of damaged cells and delivery of pro-regenerative factors, but >95% of cells die when transplanted to sites of neural injury. Biomaterial scaffolds provide cellular protective encapsulation to improve cell survival. However, current available scaffolds are overwhelmingly not approved for human use, presenting a major barrier to clinical translation. Surgical biomaterials offer the unique benefit of being FDA-approved for human implantation. Specifically, a neurosurgical grade material, DuraGen™, used predominantly for human duraplasty has many attractive features of an ideal biomaterial scaffold. Here, we have investigated the use of DuraGen™ as a 3D cell encapsulation device for potential use in combinatorial, regenerative therapies.MethodsPrimary NSCs were seeded into optimised sheets of DuraGen™. NSC growth and fate within DuraGen™ were assessed using 3D microscopic fluorescence imaging techniques.ResultsDuraGen™ supports the survival (ca 95% viability, 12 days) and 3D growth of NSCs. NSC phenotype, proliferative capacity and differentiation into astrocytes, neurons and oligodendrocytes were unaffected by DuraGen™.ConclusionsA ‘combinatorial therapy’, consisting of NSCs protected within a DuraGen™ matrix, offers a potential clinically translatable approach for neural cell therapy.

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Assunção-Silva, Rita C., Eduardo D. Gomes, Nuno Sousa, Nuno A. Silva et António J. Salgado. « Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration ». Stem Cells International 2015 (2015) : 1–24. http://dx.doi.org/10.1155/2015/948040.

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Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells. Although promising, cell transplantation is often overturned by the poor cell survival in the treatment of spinal cord injuries. Alternatively, the therapeutic role of different cells has been used in tissue engineering approaches by engrafting cells with biomaterials. The latter have the advantages of physically mimicking the CNS tissue, while promoting a more permissive environment for cell survival, growth, and differentiation. The roles of both cell- and biomaterial-based therapies as single therapeutic approaches for SCI repair will be discussed in this review. Moreover, as the multifactorial inhibitory environment of a SCI suggests that combinatorial approaches would be more effective, the importance of using biomaterials as cell carriers will be herein highlighted, as well as the recent advances and achievements of these promising tools for neural tissue regeneration.

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Kang, Phillip H., Sanjay Kumar et David V. Schaffer. « Novel biomaterials to study neural stem cell mechanobiology and improve cell-replacement therapies ». Current Opinion in Biomedical Engineering 4 (décembre 2017) : 13–20. http://dx.doi.org/10.1016/j.cobme.2017.09.005.

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Dai, Xizi, et Yen-Chih Huang. « Pluripotent Stem Cell Derived Neural Lineage Cells and Biomaterials for Neuroscience and Neuroengineering ». Journal of Neuroscience and Neuroengineering 2, n^o 2 (1 avril 2013) : 119–40. http://dx.doi.org/10.1166/jnsne.2013.1047.

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Soria, Jose Miguel, María Sancho-Tello, M. Angeles Garcia Esparza, Vicente Mirabet, Jose Vicente Bagan, Manuel Monleón et Carmen Carda. « Biomaterials coated by dental pulp cells as substrate for neural stem cell differentiation ». Journal of Biomedical Materials Research Part A 97A, n^o 1 (11 février 2011) : 85–92. http://dx.doi.org/10.1002/jbm.a.33032.

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Maclean, Francesca L., Alexandra L. Rodriguez, Clare L. Parish, Richard J. Williams et David R. Nisbet. « Integrating Biomaterials and Stem Cells for Neural Regeneration ». Stem Cells and Development 25, n^o 3 (février 2016) : 214–26. http://dx.doi.org/10.1089/scd.2015.0314.

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Thèses sur le sujet "Biomaterials, neural stem cell"

Ma, Weili. « Engineered Biomaterials for Human Neural Stem Cell Applications ». Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/594172.

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Bioengineering
Ph.D.
Within the last decade, neurodegenerative diseases such as Alzheimer’s and Parkinson’s have emerged as one of the top 5 leading causes of death globally, and there is currently no cure. All neurodegenerative diseases lead to loss of the functional cells in the nervous system, the neurons. One therapeutic approach is to replace the damaged and lost neurons with new, healthy neurons. Unfortunately, this is a difficult endeavor since mature neurons are not capable of cell division. Instead, researchers are turning to neural stem cells, which are able to self-renew and be rapidly expanded before being differentiated into functional cell phenotypes, such as neurons, allowing for large numbers of cells to be generated in vitro. Controlled differentiation of human neural stem cells into new neurons has been of interest due to the immense potential for improving clinical outcomes. Adult neural stem cell behavior, however, is not well understood and the transplanted stem cells are at risk for tumorigenesis. The focus of this dissertation is the development of engineered biomaterials as tools to study human neural stem cell behavior and neurogenesis (differentiation). A novel cell penetrating peptide was developed to enhance intracellular delivery of retinoic acid, a bioactive lipid known to induce differentiation. A hydrogel platform fabricated from hyaluronic acid, a naturally-occurring polysaccharide found in brain extracellular space, was designed to serve as a biomimetic soft substrate with similar mechanical properties to the brain. The biological behavior of the stem cells was characterized in response to chemical and physical cues.
Temple University--Theses

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Edgar, Yuji Egawa. « Biomaterials for neural cells replacement therapy ». 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199333.

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Ma, Weili. « Development of Hyaluronic Acid Hydrogels for Neural Stem Cell Engineering ». Master's thesis, Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/340372.

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Bioengineering
M.S.
In this work, a hydrogel made from hyaluronic acid is synthesized and utilized to study neural stem cell behavior within a custom tailored three dimensional microenvironment. The physical properties of the hydrogel have been optimized to create an environment conducive for neural stem cell differentiation by mimicking the native brain extracellular matrix (ECM) environment. The physical properties characterized include degree of methacrylation, swelling ratios, enzymatic degradation rates, and viscoelastic moduli. One dimensional proton nuclear magnetic resonance (1HNMR) confirms modification of the hyaluronic acid polymers, and is used to quantify the degree of methacrylation. Rheological measurements are made to quantify the viscoelastic moduli. Further post-processing by lyophilization leads to generation of large voids to facilitate re-swelling and cell infiltration. ReNcell VM (RVM), and adult human neural stem cell line derived from the ventral mesencephalon, are cultured and differentiated inside the hydrogel for up to 2 weeks. Differentiation is characterized by immunocytochemistry (ICC) and real time quantitative polymerase chain reaction (qRT-PCR).
Temple University--Theses

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Ham, Trevor Richard. « Covalent Growth Factor Tethering to Guide Neural Stem Cell Behavior ». University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555347467862553.

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TARABALLI, FRANCESCA. « Computational and experimental characterization of self-assembling peptides for nanobiomedical applications ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7475.

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The design and application of bionanotechnologies aimed at the nervous system provide powerful new approaches for studying cell and molecular biology and physiology. The successful and development of bionanotechnologies designed to interact with the nervous system as research or clinical tools requires an understanding of the relevant neurophysiology and neuropathology, and an understanding of the relevant chemistry and materials science and engineering. Materials designed molecularly for regeneration of tissues are becoming of great interest in advanced medicine and improvements in the understanding of self-assembly process offer new opportunities in molecular design of biomaterials for vary applications. In this project, two classes of biomaterials were studied with the same final achievement: the application to the regeneration of nervous systems. RADA16-I (AcN-RADARADARADARADA-CNH2), representative of a class of self-assembling peptides with alternate hydrophobic and hydrophilic residues, self-assembles into β-sheet bilayer filaments. Though molecular studies for this class of peptides has been recently developed, new investigations are required to explain how RADA16-I functionalization with biological active motifs, may influence the self-assembling tendency of new functionalized peptides (FP). Since FPs recently became a promising class of biomaterials, a better understanding of the phenomenon is necessary to design new scaffolds for cell biology and nanobiomedical applications. The first part of this project was based on the investigation with computational and experimental tools about the self-assembly of different FPs showing diverse sequences and "in vitro" behaviors. For the first time spectroscopic techniques (Raman and ATR/FTIR) was applied to these class of peptides and new vibrational modes were used to describe the nanostructure. Thanks to molecular dynamic simulations it was possible increase the experimental findings. The functionalizing self-assembling peptides can strongly influence or prevent assembly into nanostructure. Moreover the designing strategies were enhanced thanks to a deep investigation about the Glicines hinge between self assembling core and biological functionalization. The study of this structural group involved a refinement of a functionalized self-assembling peptide with the direct application on neural stem cells, and a then a future in vivo application. In the second part of this project electrospun tubes, formed by micro and nanofibers, were used to regenerate a 10-mm nerve gap in rat sciatic nerve in vivo. This work provided evidence that electrospun micro- and nanofiber PCL/PLGA channels are promising bioabsorbable scaffolds for stimulating and guiding peripheral nerve regeneration in rat models of sciatic nerve transection. This nanotechnological approach shows very encouraging results in peripheral nervous system regeneration that can ameliorate with surgery shrewdness, rehabilitative training and biomaterial modification, or better a combination of both eletrospun and self-assembling fibers. Finally in this project it was shown how a deeply investigation about self-assembling process, starting from theoretical part, could be applied directly in the development of many new biomaterials for specific nanobiomedical applications with the hope of increasing of the application range.

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Dai, Xizi. « Fiber Scaffolds of Poly (glycerol-dodecanedioate) and its Derivative via Electrospinning for Neural Tissue Engineering ». FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1852.

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Peripheral nerves have demonstrated the ability to bridge gaps of up to 6 mm. Peripheral Nerve System injury sites beyond this range need autograft or allograft surgery. Central Nerve System cells do not allow spontaneous regeneration due to the intrinsic environmental inhibition. Although stem cell therapy seems to be a promising approach towards nerve repair, it is essential to use the distinct three-dimensional architecture of a cell scaffold with proper biomolecule embedding in order to ensure that the local environment can be controlled well enough for growth and survival. Many approaches have been developed for the fabrication of 3D scaffolds, and more recently, fiber-based scaffolds produced via the electrospinning have been garnering increasing interest, as it offers the opportunity for control over fiber composition, as well as fiber mesh porosity using a relatively simple experimental setup. All these attributes make electrospun fibers a new class of promising scaffolds for neural tissue engineering. Therefore, the purpose of this doctoral study is to investigate the use of the novel material PGD and its derivative PGDF for obtaining fiber scaffolds using the electrospinning. The performance of these scaffolds, combined with neural lineage cells derived from ESCs, was evaluated by the dissolvability test, Raman spectroscopy, cell viability assay, real time PCR, Immunocytochemistry, extracellular electrophysiology, etc. The newly designed collector makes it possible to easily obtain fibers with adequate length and integrity. The utilization of a solvent like ethanol and water for electrospinning of fibrous scaffolds provides a potentially less toxic and more biocompatible fabrication method. Cell viability testing demonstrated that the addition of gelatin leads to significant improvement of cell proliferation on the scaffolds. Both real time PCR and Immunocytochemistry analysis indicated that motor neuron differentiation was achieved through the high motor neuron gene expression using the metabolites approach. The addition of Fumaric acid into fiber scaffolds further promoted the differentiation. Based on the results, this newly fabricated electrospun fiber scaffold, combined with neural lineage cells, provides a potential alternate strategy for nerve injury repair.

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Erlandsson, Anna. « Neural Stem Cell Differentiation and Migration ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3546.

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Hopp, I. « Novel synthetic biomaterials for kidney-derived progenitor/stem cell differentiation ». Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004383/.

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End-stage kidney disease is increasing in prevalence and is associated with high levels of morbidity and mortality. At present, the only treatment options are dialysis or renal transplantation. However, dialysis is very costly and is associated with high levels of morbidity, whereas the problem with transplantation is that there is a shortage of organ donors. For these reasons, over recent years, there has been an increasing interest in developing novel therapies in the field of regenerative medicine including stem cell based therapies and tissue engineering. Stem cells could be used in a number of ways to develop new therapies for kidney disease. Firstly, they could be administered as cell therapies to patients with kidney disease, and secondly, they could be used to generate specific types of renal cells in vitro that could be used for understanding disease mechanisms and for drug discovery programmes. The barriers to the development of novel stem cell therapies include the difficulties in expanding kidney-derived stem cells in culture without altering their phenotype, and directing their differentiation to specific types of renal cells. These issues could be addressed by developing biomaterial substrates that provide an appropriate microenvironment for the successful culture and differentiation of stem cells. Within this study we interrogated a wide range of biomaterial substrates for their capability to direct the differentiation of kidney derived progenitor / stem cells. These materials were thoroughly characterised in terms of their physicochemical properties, such as surface chemistry, nanotopography and wettability by employing a wide range of analytic techniques, including X-Ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), colorimetry and contact angle measurements. We firstly investigated a range of polyacrylates. These substrates were novel in that, they were precisely designed to mimic cell binding motifs of the extracellular matrix stereochemically by using monomeric precursors that display particular chemical functional group chemistries, namely amine, hydroxyl, carboxyl groups or aliphatic spacer groups. We found that these materials differed strongly in the presence and distribution of surface functional group chemistries and topographical features, including the distribution of surface artefacts on a macroscale. Moreover, some of these materials were able to direct the differentiation into specialised renal cell lines. Two substrates, namely ESP 003 and ESP 004, directed the differentiation of kidney derived stem cells into podocytes and two further substrates, namely ESP 007 and BTL 15, directed differentiation into functional proximal tubule cells. These four substrates stimulated cell differentiation to an extent of about 40 to 50% after only 96 h in cell culture. We were moreover able to identify surface physicochemical cues, including surface micro- and nanoscale topography and surface functional group chemistries that are important to stimulate the differentiation process. In addition, we investigated a range of plasma polymer coatings composed of allylamine and octadiene that were provided as homo-or copolymers and in form of chemical gradients, the latter one differing in the amount of nitrogen functional group chemistries across the surfaces. We found that substrates with higher allylamine content displayed a greater amount of nitrogen functional groups and therefore increased in wettability. Moreover, those plasma polymer substrates with higher amine functionality directed kidney progenitor cell differentiation into podocytes, whereas substrates with higher octadiene concentration directed cell differentiation into functional proximal tubule cells, both to an extent of 35 to 45% after only 96 h in culture. To further study cell differentiation, we then incorporated gold nanoparticles underneath these plasma coatings, either in form of homogeneous coatings or in form of a nanoparticle density gradient. We found that surface topographic gradients increased cell differentiation into podocytes 3- to 4-fold, whereas differentiation into proximal tubule cells was only dependent on surface chemistry. Our studies on plasma polymer substrates highlighted not only the great potential of plasma polymers to modify surface functionality of a wide range of surfaces, but also emphasized the great capabilities of surface gradients, whether chemical or topographical in nature, to effect cellular fate. In summary, the results of this study include the identification of biomaterial substrates that have the potential to differentiate kidney-derived progenitor/stem cells in vitro and of the cues that are necessary to assist in the differentiation process. In the future, these biomaterials could be useful for directing the differentiation of pluripotent stem cell-derived renal progenitors to specific types of renal cells that could be used for applications in regenerative medicine and drug discovery programmes.

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Clem, William Charles. « Mesenchymal stem cell interaction with nanonstructured biomaterials for orthopaedic applications ». Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/clem.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2008.
Additional advisors: Yogesh K. Vohra, Xu Feng, Jack E. Lemons, Timothy M. Wick. Description based on contents viewed July 8, 2009; title from PDF t.p. Includes bibliographical references.

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Albertson, Roger Joseph. « Establishing asymmetry in Drosophila neural stem cells / ». view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3112998.

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Thesis (Ph. D.)--University of Oregon, 2003.
Typescript. Includes vita and abstract. Includes bibliographical references (leaves 101-117). Also available for download via the World Wide Web; free to University of Oregon users.

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Livres sur le sujet "Biomaterials, neural stem cell"

Kaur, Navjot, et Mohan C. Vemuri, dir. Neural Stem Cell Assays. Hoboken, NJ, USA : John Wiley & Sons, Inc, 2014. http://dx.doi.org/10.1002/9781118308295.

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V, Greer Erik, dir. Neural stem cell research. New York : Nova Science Publishers, 2006.

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Roy, Krishnendu, dir. Biomaterials as Stem Cell Niche. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13893-5.

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E, Bottenstein Jane, dir. Neural stem cells : Development and transplantation. Boston : Kluwer Academic Publishers, 2003.

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Neil, Scolding, dir. Neural cell transplantation : Methods and protocols. New York : Humana, 2009.

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Taupin, Philippe. Neural stem cells and cellular therapy. Hauppauge, NY : Nova Science Publishers, 2009.

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Taupin, Philippe. Neural stem cells and cellular therapy. Hauppauge, NY : Nova Science Publishers, 2009.

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Taupin, Philippe. Adult neurogenesis and neural stem cells in mammals. New York : Nova Science Publishers, 2006.

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Paul, Alexander J. Local and Long-range Regulation of Adult Neural Stem Cell Quiescence. [New York, N.Y.?] : [publisher not identified], 2016.

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Neural stem cells in health and diseases. New Jersey : World Scientific, 2015.

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Chapitres de livres sur le sujet "Biomaterials, neural stem cell"

Amiryaghoubi, Nazanin, Marziyeh Fathi, Khosro Adibkia, Jaleh Barar, Hossein Omidian et Yadollah Omidi. « Chitosan-Based Biomaterials : Their Interaction with Natural and Synthetic Materials for Cartilage, Bone, Cardiac, Vascular, and Neural Tissue Engineering ». Dans Engineering Materials for Stem Cell Regeneration, 619–50. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4420-7_22.

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Kaphle, Pranita, Li Yao et Joshua Kehler. « Stem Cell- and Biomaterial-Based Neural Repair for Enhancing Spinal Axonal Regeneration ». Dans Glial Cell Engineering in Neural Regeneration, 59–84. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02104-7_4.

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Nanduri, Lalitha Sarad Yamini. « Chitosan–Stem Cell Interactions ». Dans Chitosan for Biomaterials III, 343–59. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/12_2021_83.

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Parekh, Yash, Ekta Dagar, Khawaja Husnain Haider et Kiran Kumar Bokara. « Neural Stem Cells ». Dans Handbook of Stem Cell Therapy, 821–47. Singapore : Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2655-6_38.

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Parekh, Yash, Ekta Dagar, Khawaja Husnain Haider et Kiran Kumar Bokara. « Neural Stem Cells ». Dans Handbook of Stem Cell Therapy, 1–27. Singapore : Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6016-0_38-1.

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Mateos-Timoneda, Miguel Angel, Melba Navarro et Josep Anton Planell. « Bioresponsive Surfaces and Stem Cell Niches ». Dans Biomaterials Surface Science, 269–84. Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527649600.ch9.

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Genchi, Angela, Beatrice Von Wunster, Paola Panina-Bordignon et Gianvito Martino. « Neural Stem Cell Biology ». Dans Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases, 78–85. Boca Raton : CRC Press, 2021. http://dx.doi.org/10.1201/9781315151366-9.

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Castrén, Maija. « Neural Stem Cells ». Dans Results and Problems in Cell Differentiation, 33–40. Berlin, Heidelberg : Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21649-7_3.

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Kubis, Nathalie, et Martin Catala. « Neural Stem Cells ». Dans Stem Cell Biology and Regenerative Medicine, 461–94. 2^e éd. New York : River Publishers, 2022. http://dx.doi.org/10.1201/9781003339618-18.

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Kubis, Nathalie, et Martin Catala. « Neural Stem Cells ». Dans Stem Cell Biology and Regenerative Medicine, 477–97. New York : River Publishers, 2022. http://dx.doi.org/10.1201/9781003339601-22.

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Actes de conférences sur le sujet "Biomaterials, neural stem cell"

Monteiro, Gary A., et David I. Shreiber. « Guiding Stem Cell Differentiation Into Neural Lineages With Tunable Collagen Biomaterials ». Dans ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206752.

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The long-term objective of this research is to develop tunable collagen-based biomaterial scaffolds for directed stem cell differentiation into neural lineages to aid in CNS diseases and trauma. Type I collagen is a ubiquitous protein that provides mechanostructural and ligand-induced biochemical cues to cells that attach to the protein via integrin receptors. Previous studies have demonstrated that the mechanical properties of a substrate or tissue can be an important regulator of stem cell differentiation. For example, the mechanical properties polyacrylamide gels can be tuned to induce neural differentiation from stem cells [1, 2]. Mesenchymal stem cells (MSCs) cultured on ployacrylamide gels with low elastic modulus (0.1–1 kPa) resulted in a neural like population. MSCs on 10-fold stiffer matrices that mimic striated muscle elasticity (Emuscle ∼8–17 kPa) lead to spindle-shaped cells similar in shape to myoblasts. Still stiffer gels (25–40 kPa) resulted in osetoblast differentiation. Based on these observations, collagen gels may provide an ideal material for differentiation into neural lineages because of their low compliance.

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Kawazoe, Naoki, Likun Guo, Guoping Chen et Tetsuya Tateishi. « Manipulation of Stem Cell Functions On Grafted Polymer Surfaces ». Dans In Commemoration of the 1st Asian Biomaterials Congress. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812835758_0015.

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Chirasatitsin, Somyot, Priyalakshmi Viswanathan, Giuseppe Battaglia et Adam J. Engler. « Directing Stem Cell Fate in 3D Through Cell Inert and Adhesive Diblock Copolymer Domains ». Dans ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14442.

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Adhesions are important cell structures required to transduce a variety of chemical and mechanics signals from outside-in and vice versa, all of which regulate cell behaviors, including stem cell differentiation (1). Though most biomaterials are coated with an adhesive ligand to promote adhesion, they do not often have a uniform distribution that does not match the heterogeneously adhesive extracellular matrix (ECM) in vivo (2). We have previously shown that diblock copolymer (DBC) mixtures undergo interface-confined de-mixing to form nanodomins of one copolymer in another (3). Here we demonstrate how diblock copolymer mixtures can be made into foams with nanodomains to better recapitulate native ECM adhesion regions and influence cell adhesion.

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Khetan, Sudhir, Wesley R. Legant, Christopher S. Chen et Jason A. Burdick. « Stem Cell Fate Within 3D Hydrogels is Mediated by Network Structure-Dependent Traction Generation ». Dans ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80277.

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A continuing goal in biomaterials research is to understand how cell adhesion to the surrounding materials and/or matrix regulates cell behavior in 3D. Advanced understanding of these processes may aid the development of synthetic biomaterials for tissue engineering applications, as well as to help understand basic cellular processes. The majority of past work, however, has focused on cell behavior atop 2D substrates that poorly recapitulate the 3D in vivo microenvironment [1]. Recent reports have suggested that within 3D hydrogels, encapsulated human mesenchymal stem cell (hMSC) fate is not determined by cell morphology or matrix mechanics alone [2], but by gel-structure dependent traction force generation [3]. As hMSCs represent a promising cell source for regenerative applications [4], it is critical to better develop our understanding of the link between cell fate and microenvironmental physical and biochemical cues in 3D, with a focus on the range of materials used in regenerative medicine. In the current work, hMSCs were encapsulated within degradable and non-degradable hyaluronic acid (HA) hydrogels of similar elastic moduli to assess the influence of hydrogel remodeling and cellular traction generation on differentiation lineage specification.

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Fadhilah, Shabrina, et Yudan Whulanza. « Flow focusing microfluidics or stem cell dual layers droplet microencapsulation ». Dans THE 5TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES : Proceedings of the 5th International Symposium of Biomedical Engineering (ISBE) 2020. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0047168.

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Rigaud, Stéphane U., et Nicolas Loménie. « Neural stem cell tracking with phase contrast video microscopy ». Dans SPIE Medical Imaging, sous la direction de Benoit M. Dawant et David R. Haynor. SPIE, 2011. http://dx.doi.org/10.1117/12.877651.

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Chen, Taoyi, Yong Zhang, Changhong Wang, Zhenshen Qu et Stephen T. C. Wong. « Neural stem cell segmentation using local complex phase information ». Dans 2010 17th IEEE International Conference on Image Processing (ICIP 2010). IEEE, 2010. http://dx.doi.org/10.1109/icip.2010.5652071.

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Juncosa-Melvin, Natalia, Jason T. Shearn, Marc T. Galloway, Gregory P. Boivin, Cynthia Gooch et David L. Butler. « Effect of Mechanical Stimulation on the Biomechanics of Stem Cell : Collagen Sponge Constructs for Patellar Tendon Repair ». Dans ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175814.

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Tendons (rotator cuff, Achilles and patellar tendons) are among the most commonly injured soft tissues [1]. Many techniques for repair/reconstruction have been attempted (e.g. sutures, resorbable biomaterials, autografts, and allografts) with varying success. A tissue engineered repair using mesenchymal stem cells (MSCs) is and attractive option [2–4] but the stiffness and strength of currently available constructs are insufficient for clinical use [6].

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Kato-Negishi, Midori, Hiroaki Onoe et Shoji Takeuchi. « Specially patterned and aligned neural bundle formed by neural stem cell microfibers ». Dans 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2013. http://dx.doi.org/10.1109/memsys.2013.6474194.

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Ratushnyak, Mariya, et Yuliya Semochkina. « STEM CELL EXOSOMES CAN IMPROVE THE SURVIVAL OF NEURAL STEM CELLS AFTER RADIATION EXPOSURE ». Dans XVIII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2022. http://dx.doi.org/10.29003/m2901.sudak.ns2022-18/282-283.

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Rapports d'organisations sur le sujet "Biomaterials, neural stem cell"

Felding-Habermann, Brunhilde. Neural Stem Cell Delivery of Therapeutic Antibodies to Treat Breast Cancer Brain Metastases. Fort Belvoir, VA : Defense Technical Information Center, octobre 2009. http://dx.doi.org/10.21236/ada541313.

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