Thèses : « Biochemical of exercises »

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Mizuno, Julio [UNESP]. « Efeitos de uma sequência de prática do yoga sobre parâmetros bioquímicos e hemodinâmicos de pacientes com hipertensão arterial ». Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/87401.

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A prática de exercícios de Yoga pode proporcionar inúmeros benefícios à saúde, atuando como terapia complementar em patologias como a hipertensão arterial. O objetivo deste estudo foi descrever os efeitos de uma combinação de seqüências de práticas de yoga realizadas durante quatro meses sobre os parâmetros hemodinâmicos (frequência cardíaca e pressão arterial), bioquímicos (concentração plasmática de colesterol e suas frações, triglicerídeos e glicemia) e a percepção da qualidade de vida em pacientes portadores de hipertensão arterial. Trinta e três voluntários (64±9 anos) participaram do estudo. Três homens e 14 mulheres (68±7 anos) realizaram aulas de yoga durante quatro meses (GY), enquanto dois homens e 14 mulheres (58±8 anos) constituíram o grupo controle (GC), sem intervenção. Os alunos do GY compareceram nas aulas três vezes por semana e realizaram exercícios de yoga em uma seqüência composta por alongamentos, exercícios de respiração, posturas do yoga, relaxamento e meditação. Durante o experimento foram observadas a pressão arterial sistólica e diastólica, frequência cardíaca e respiratória, perfil bioquímico (glicemia de jejum, colesterol total, LDL-colesterol, HDL-colesterol e triglicerídeos) e qualidade de vida (SF-36). Os dados foram submetidos a análise estatística para verificar a normalidade (Shapiro Wilk), a diferença entre os grupos (Mann-Whitney) e entre momentos pré e pós intervenção (Wilcoxon); a variação ao longo dos meses (ANOVA para medidas repetidas) e correlação entre valores iniciais e diferenças finais (Sperman). Foi adotado nível de significância de p<0,05. Os resultados apontaram melhora significativa no valor médio de pressão arterial sistólica final do GY comparado com o valor inicial (113,8±7,7 versus 120,7±7,9; p<0,05), enquanto a pressão arterial diastólica não apresentou diferenças...
The practice of Yoga exercises can provide numerous health benefits, acting as a complementary therapy in diseases like hypertension. The aim of this study was to describe the effects of a combination of yoga sequences carried out during four months, on the hemodynamic parameters (heart rate and blood pressure), biochemical (plasma cholesterol concentrations and its fractions, triglycerides and glucose) and the perception of quality of life in hypertension patients. Thirty-three volunteers (64 ± 9 years) participated in the study. Three men and 14 women (68 ± 7 years) conducted yoga classes for four months (YG), while two men and 14 women (58 ± 8 years) constituted the control group (CG) without intervention. The yoga goers attended the YG classes three times a week and did yoga exercises in a sequence consisting of stretching, breathing exercises, yoga postures, relaxation and meditation. During the experiment it was measured systolic and diastolic blood pressure, heart rate and respiratory rate, biochemical profile (fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) and quality of life (SF-36). Data were subjected to statistical analysis to ensure normality (Shapiro Wilk), the difference between the groups (Mann-Whitney test) and between pre and post intervention (Wilcoxon), the variation over the months (repeated measures ANOVA) and correlation differences between initial and final values (Spearman). The significance level was p <0.05. The results showed significant improvement in the average of final systolic blood pressure compared with the initial value (113.8 ± 7.7 versus 120.7 ± 7.9, p <0.05) in the YG, while diastolic blood pressure did not showed differences between times. In the CG the initial and final mean of systolic and diastolic blood pressure showed no difference statistically significant. Regarding the biochemical profile, we found... (Complete abstract click electronic access below

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Mizuno, Julio. « Efeitos de uma sequência de prática do yoga sobre parâmetros bioquímicos e hemodinâmicos de pacientes com hipertensão arterial / ». Rio Claro : [s.n.], 2010. http://hdl.handle.net/11449/87401.

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Orientador: Henrique Luiz Monteiro
Banca: Angelina Zanesco
Banca: Elisa Harumi Kozasa
Resumo: A prática de exercícios de Yoga pode proporcionar inúmeros benefícios à saúde, atuando como terapia complementar em patologias como a hipertensão arterial. O objetivo deste estudo foi descrever os efeitos de uma combinação de seqüências de práticas de yoga realizadas durante quatro meses sobre os parâmetros hemodinâmicos (frequência cardíaca e pressão arterial), bioquímicos (concentração plasmática de colesterol e suas frações, triglicerídeos e glicemia) e a percepção da qualidade de vida em pacientes portadores de hipertensão arterial. Trinta e três voluntários (64±9 anos) participaram do estudo. Três homens e 14 mulheres (68±7 anos) realizaram aulas de yoga durante quatro meses (GY), enquanto dois homens e 14 mulheres (58±8 anos) constituíram o grupo controle (GC), sem intervenção. Os alunos do GY compareceram nas aulas três vezes por semana e realizaram exercícios de yoga em uma seqüência composta por alongamentos, exercícios de respiração, posturas do yoga, relaxamento e meditação. Durante o experimento foram observadas a pressão arterial sistólica e diastólica, frequência cardíaca e respiratória, perfil bioquímico (glicemia de jejum, colesterol total, LDL-colesterol, HDL-colesterol e triglicerídeos) e qualidade de vida (SF-36). Os dados foram submetidos a análise estatística para verificar a normalidade (Shapiro Wilk), a diferença entre os grupos (Mann-Whitney) e entre momentos pré e pós intervenção (Wilcoxon); a variação ao longo dos meses (ANOVA para medidas repetidas) e correlação entre valores iniciais e diferenças finais (Sperman). Foi adotado nível de significância de p<0,05. Os resultados apontaram melhora significativa no valor médio de pressão arterial sistólica final do GY comparado com o valor inicial (113,8±7,7 versus 120,7±7,9; p<0,05), enquanto a pressão arterial diastólica não apresentou diferenças... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The practice of Yoga exercises can provide numerous health benefits, acting as a complementary therapy in diseases like hypertension. The aim of this study was to describe the effects of a combination of yoga sequences carried out during four months, on the hemodynamic parameters (heart rate and blood pressure), biochemical (plasma cholesterol concentrations and its fractions, triglycerides and glucose) and the perception of quality of life in hypertension patients. Thirty-three volunteers (64 ± 9 years) participated in the study. Three men and 14 women (68 ± 7 years) conducted yoga classes for four months (YG), while two men and 14 women (58 ± 8 years) constituted the control group (CG) without intervention. The yoga goers attended the YG classes three times a week and did yoga exercises in a sequence consisting of stretching, breathing exercises, yoga postures, relaxation and meditation. During the experiment it was measured systolic and diastolic blood pressure, heart rate and respiratory rate, biochemical profile (fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) and quality of life (SF-36). Data were subjected to statistical analysis to ensure normality (Shapiro Wilk), the difference between the groups (Mann-Whitney test) and between pre and post intervention (Wilcoxon), the variation over the months (repeated measures ANOVA) and correlation differences between initial and final values (Spearman). The significance level was p <0.05. The results showed significant improvement in the average of final systolic blood pressure compared with the initial value (113.8 ± 7.7 versus 120.7 ± 7.9, p <0.05) in the YG, while diastolic blood pressure did not showed differences between times. In the CG the initial and final mean of systolic and diastolic blood pressure showed no difference statistically significant. Regarding the biochemical profile, we found... (Complete abstract click electronic access below
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Basnet, Ram Manohar. « Biochemical correlates of synaptic plasticity in exercise ». Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17375.

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Current views of the brain are shifting towards a more changeable, plastic brain than previously envisaged. Physical training has been shown to be one of few strategies that seems able to increase the plasticity of the brain. Little is known, however, about the molecular mechanisms that regulate synaptic plasticity during training. The aim of the project is to explore training based synaptic plasticity at a molecular level, focusing primarily on the excitatory glutamatergic synapses. Most of the research done on exercise has been focused on a specific brain region. I have tried to investigate global effects of exercise on the synapse. Crude synaptosomes were prepared from trained and sedentary groups of mice, and semiquantitative western blotting was done to determine possible changes in synaptic expression of functionally crucial proteins, i.a. glutamate receptors. I found increased level of syntaxin, GluR1 AMPA receptor subunits, and the 2A/2B subunits of the NMDA receptor. There was also a decreased level of Arc in trained compared to sedentary mice. There was no significant change in the expression of the neuronal marker, beta tubulin, of the synaptic markers synaptophysin and PSD-95, or in the AMPA receptor subunit GluR2. Taken together, my results may indicate that physical exercise may lead to an increased level of ongoing hebbian plasticity, a reduction in homeostatic plasticity, an increased presynaptic release capacity, with no apparent change in the density of neurons or synapses.

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Liu, Xun. « Physiological and biochemical changes during cardiac rehabilitation ». Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368005.

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Meulen, Jacob Hendrikus van der. « Exercise-induced muscle damage : morphological, biochemical and functional aspects ». [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=5654.

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Kerr, Morag Graham. « Biochemical and physiological aspects of endurance exercise in the horse ». Thesis, University of Glasgow, 1985. http://theses.gla.ac.uk/3993/.

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A number of biochemical and haematological changes are known to occur in horses involved in long distance riding competitions of 40- 160 km, particularly changes associated with disturbances in fluid/ electrolyte balance, catabolism of body fuel stores and alterations in the integrity of the muscle cell membrane. This study investigated these changes in more detail in 50 horses involved in competitive rides and in four horses undergoing two 80 km rides under controlled conditions. In addition, experiments were carried out on horses and ponies exposed to a hot, humid environment (41°C, 33°C wet bulb) and during intravenous adrenaline infusion, in order to study further the fluid/ electrolyte alterations associated with sweating and in particular the composition of equine sweat. Changes in plasma and urine biochemistry were also studied over 24 hours in horses at rest for comparative purposes. Significant changes were shown in 13 of the 14 plasma parameters measured in the resting horses. Most of these could be related to feeding, in particular to hay feeding which caused alterations in fluid/ electrolyte balance associated with salivary secretion. Urine composition changed very markedly during the 24 hours. Urine flow rate and creatinine and urea excretion were higher during the day and increased following drinking, as in man. Urine potassium and chloride excretion were much higher than sodium excretion and all three electrolytes (and pH, which was alkaline) showed diurnal variations markedly different from those in man. The competing endurance horses demonstrated moderate haemoconcentration, but plasma electrolyte alterations, particularly an increase in sodium concentration, were not always consistent with the production of apparently hypertonic sweat. The pattern of fuel utilisation was one of exhaustion of liver glycogen after about 40 km with extensive fat mobilisation and the use of glycerol for gluconeogenesis. Breakdown of phosphocreatine was extensive and evidence of protein catabolism was observed. Large variable increases in plasma CK and AST activities unassociated with fatigue suggested a non-pathological alteration in muscle cell membrane integrity in a number of horses. During heat exposure changes in PCV and plasma proteins were poorly related to fluid losses but changes in electrolyte concentrations were consistent with the sweat tonicity. Hypertonic chloride and potassium, and isotonic sodium concentrations (relative to plasma) were maintained in the sweat for 4.5 hours. In contrast sweat magnesium and protein concentrations were initially high but decreased exponentially with time. There was a very close correlation between these two parameters. Most of the changes in plasma parameters seen during adrenaline infusion were attributable to the adrenaline per se, but the profuse sweating induced in the horses caused some haemoconcentration. Small ponies sweated much less in response to adrenaline than Thoroughbred horses. Hypertonic sweat concentrations of chloride, sodium and potassium were maintained for 3 hours and significant differences, particularly in Na/K ratio, were found between heat and adrenalineinduced sweat. Sweat urea concentration was related to plasma urea concentration and glucose appeared in the sweat when the plasma glucose concentration exceeded 10 - 12 mmol/l. The sweat magnesium was not protein-bound and the two main electrophoretic fractions of the sweat protein were not present in serum. The possible function of this protein as a wetting agent was discussed. During the controlled 80 km rides total fluid loss was 33.5% of the total ECF volume: 78% of this was sweat and 22% respiratory evaporation. Although sweat electrolyte concentrations were again hypertonic to plasma, theoretical concentrations in total body (sweat plus respiratory) water loss were much closer to plasma concentrations - slightly hypotonic for sodium, slightly hypertonic for chloride. As a result changes in plasma electrolyte concentrations were small, an increase of 9 mmol/1 (5.7%) in sodium and a decrease of 4 mmol/l (3.5%) in chloride. Potassium appeared to move out of the intracellular fluid at the start of exercise and back in immediately afterwards and this obscured any effect of sweat losses on plasma concentration. The only urinary constituent which was conserved in the exercising horses was chloride, and the absence of any decrease in urea excretion suggested that the increase in plasma urea concentration was due to increased protein catabolism, probably from the liver. Body fuel utilisation was similar to that seen in the competing horses and plasma CK and AST activities again suggested that a non-pathological disruption of muscle cell membrane integrity was occurring in some horses which continued intermittently for several months. It was concluded that in the horse, unlike man, the thermoregulatory fluid is approximately isotonic to plasma, which minimises electrolyte imbalances and allows prolonged exercise with less need for drinking. After exercise the large caecum and colon and the sodium contained in them appear to be important in the controlled replacement of the extensive water and electrolyte losses which result.

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Polychronis, Jan A. « Energy cost of resistive exercise ». PDXScholar, 1989. https://pdxscholar.library.pdx.edu/open_access_etds/3926.

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The energy cost of performing 1 and 3 sets of strength-type (6-8 RM) and endurance-type (30-35 RM) bench press exercise was estimated by indirect calorimetry in 10 male college students. The total net energy cost of performing 3 sets of endurance-type resistive exercise (20.57 ± 1.86 kcal) was significantly (p-1) the strength-type exercise (2.35 ± 0.19) resulted in a significantly (p

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Li, feifei. « Effects of maximal intermittent exercise in normoxic and hypoxic environments on the release of cardiac biomarkers and the potential mechanism ». HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/41.

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The purposes of this study were 1) to investigate the release of cardiac biomarkers resulting from acute bouts of maximal intermittent exercise in a laboratory-based setting and set up an exercise-induced cardiac biomarker release (EICBR) model; 2) to compare the changes in cardiac biomarkers in normoxic and hypoxic environments and determine the effects of hypoxia; 3) to investigate the changes in oxidative stress biomarkers resulting from acute bouts of maximal intermittent exercise in normoxic and hypoxic environments at multiple time points; and 4) to observe the relationship between oxidative stress and EICBR and explore the hypothesis that lipid peroxidation triggers the release of cardiac biomarkers from the cytosolic pool. The maximal oxygen consumption (VO2max) and the corresponding velocity of VO2max (vVO2max) of ten well-trained male marathon runners (age 22.1±2.6 y, body mass 64.0±4.9 kg and height 177.3±3.9 cm) was determined under normoxic (FIO2=21.0%, VO2max_N=64.72±5.63 ml∙kg-1∙min-1 and vVO2max_N=18.2±1.0 km∙h-1) and hypoxic (FIO2=14.4%, VO2max_H=62.16±6.74 ml∙kg-1∙min-1 and vVO2max_H=16.7±0.7 km∙h-1) conditions in two experimental trials. One set of conditions was tested in each trial. The order in which each participant faced each trial was selected at random and the trials were separated by 72 h. The ten participants also completed three maximal intermittent exercise protocols, under normoxic (trial N, FIO2=21.0%), absolutely hypoxic (trial AH, FIO2=14.4%) and relatively hypoxic (trial RH, FIO2=14.4%) conditions. The order in which the participants faced the three conditions was once again selected at random and the protocols were separated by at least 7 d. Each bout of maximal intermittent exercise in trials N and AH consisted of a hard run of 16.4±0.9 km∙h-1 (90% vVO2max_N) for 2 min, followed by an easy run of 9.1±0.5 km∙h-1 (50% vVO2max_N) for 2 min with a 2% slope. In trial RH, each bout of exercise consisted of a hard run of 15.0±0.6 km∙h-1 (90% vVO2max_H) for 2 min, followed by an easy run of 8.4±0.3 km∙h-1 (50% vVO2max_H) for 2 min with a 2% slope. Each of the three trials consisted of 23 bouts of maximal intermittent exercise, performed over 92 min. Measurements of the serum of the antecubital venous blood were performed pre- and post- (0 h, 2 h, 4 h and 24 h) exercise. The measurements were taken at five time points for each of the three conditions. The cardiac damage biomarkers of high sensitivity cardiac troponin T (hs-cTnT) and cardiac troponin I (cTnI) and the oxidative stress biomarkers of malondialdehyde (MDA), lipid hydroperoxide (LH), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total antioxidant capacity (TAOC) were analysed. Heart rate (HR) and arterial oxygen saturation (SaO2) were recorded before and during exercise. Due to the skewed distribution of the data (P<0.05), a non-parametric Friedman’s test was used to compare the differences in the levels of hs-cTnT and cTnI between pre- and post-exercise and at each time point for the three conditions. MDA, LH, SOD, CAT, GSH, TAOC and HR were normally distributed (P>0.05) and were analysed using one-way repeated ANOVA tests. Pearson’s product moment correlation coefficients were used to determine the degree of association between the peak levels of hs-cTnT and cTnI, and MDA, LH, SOD, CAT, GSH and TAOC. In trial N, the level of hs-cTnT was elevated 0 h post-exercise (9.628±3.797 pg∙ml-1 was significantly different from the pre-exercise level of 5.118±1.857 pg∙ml-1, P=0.005), reached its peak level 2 h post-exercise (24.290±18.628 pg∙ml-1 was significantly different from the pre-exercise level, P=0.005) and returned to the baseline level at 24 h post-exercise (5.978±1.849 pg∙ml-1). The peak levels of hs-cTnT (N, AH 37.001±31.995 pg∙ml-1, RH 28.614±23.628 pg∙ml-1) and cTnI (N 0.0375±0.0437 ng∙ml-1, AH 0.0475±0.0533 ng∙ml-1, RH 0.0345±0.0375 ng∙ml-1) did not significantly differ under the three conditions. In trial AH, the peak levels of hs-cTnT (2 h, 4 h) and cTnI (2 h, 4 h) were highly related to the MDA_0h and the TAOC_24h. In trial RH, the peak levels of hs-cTnT (2 h, 4 h) and cTnI (2 h, 4 h) were highly related to the TAOC_4h. It was concluded that maximal intermittent exercise can be used to trigger EICBR. The stimulus of hypoxia did not induce more cardiac damage in this exercise model. Maximal intermittent exercise potentially triggers EICBR through oxidative stress, especially lipid peroxidation. Keywords: cardiac biomarkers, hs-cTnT, cTnI, oxidative stress, hypoxia

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Almarwaey, Omar A. O. « Physiological and biochemical responses to exercise and training in adolescent runners ». Thesis, Liverpool John Moores University, 2006. http://researchonline.ljmu.ac.uk/5807/.

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This thesis aims to identify physiological and biochemical variables, comparing sex, training status, age and maturity in sub-elite, endurance trained adolescents. Maximal lactate steady state was investigated and the effects of endurance training programmes measured.T he first study assessedth e reliability of absolute running speed, V02, and HR that correspond to the fixed blood lactate reference values of 2.0 and 2.5 mmo1. L"1 and the lactate threshold (LT) and found these measures to be reliable after endurance-trained adolescent runners completed two identical incremental treadmill tests within a 7-10 d period The second study was designed to determine the relationship between physiological variables and endurance running performance in this age group. Track-based, running performance times were available for 18 boys and 14 girls for the 800 m, and 16 boys and 13 girls for the 1500 m. The participants were tested using a step-wise incremental treadmill test and a Wingate anaerobic power test (WAnT) on separate occasions. The results from this study found that for the 1500m, running speeds corresponding to the fixed [BLa ] were a useful measure for assessing performance in endurance trained boys and girls. Unlike previous studies, peak V02 was not a significant physiological predictor of 1500m performance in either boys or girls. For the 1500 m performance in girls the anaerobic measure was no longer significant once variations in size or age had been taken into consideration. Whereas V VO2 peak and running economy may prove to be of some value when considering the 800m for boys, the running speed corresponding to a [BLa ] of 2.5 mmol-L-1 was the only meaningful physiological predictor variable for girls once differences in age and body size had been accounted for. The third study had three main objectives: (1) to identify the exercise intensity that corresponds to the (MLaSS) in adolescent, endurance trained runners, (2) to examine possible between sex differences, and (3) to compare the MLaSS with commonly cited fixed blood lactate reference variables. The participants were first tested using a step-wise incremental treadmill test to establish the blood lactate profile and peak VO 2. The running speed and % peak VO 2 at the MLaSS were not significantly different to those corresponding to the fixed [BL& ] of 2.0 and 2.5 mmol-L-1 (P>0.05). The % HR max at 2.5 mmol-L-1 was also not different to that at the MLaSS, whereas at 2.0 mmol-L-1 it was slightly lower (P<0.05). The running speed, % peak VO 2, and % HR max at the fixed [BLa] of 4.0 mmol-L-1 were significantly higher than those at the MLaSS (P<0.05). In conclusion, it is clear that the MLaSS corresponded to the relatively high exercise intensity in this sample of athletes. It would appear that the running speed, % peak VO 2, and % HR max at the MLaSS lies somewhere between the fixed [BLa ] of 2.0 and 2.5 mmol"L-1. These results confirm earlier work that has suggested a fixed [BLa ] of 2.5 mmol-L-1 may be used with young people' to assess and monitor endurance running performance in place of the more commonly used 4.0 mmol-L-1 that has received so much attention in adult-based studies. The fourth study examined the effect of exercise training on endurance performance, blood lactate profile in relation to running speed (RV) and cardio respiratory function (peak V02) in adolescent runners. This study demonstrated that resting HR, LT and 1 Use of the expression young people is increasingly common since the publication of the text, Young People and Physical Activity by Armstrong and Weisman in 1997. It is used within this document to generically represent the 6 to 18 year age group. 11 RV, HR, V02 and peak V02 at LT were significantly influenced by endurance training. When running time, running velocity and run performance time pre and postintervention were included in the analysis, the intervention did not have a significant effect on peak VO2. When percentage body fat was included as a covariate, there was a positive association with pre and post-training for all groups. The conclusion from these data is that maturity and training both have an effect, especially at supra suggested training levels. The results of the four inter-linked studies support an age-related increase in endurance in aerobic and anaerobic performance and indicated significant differences between boys and girls. From a coaching viewpoint the results reveal that, from the age of 14 to 18 years, runners should be introduced to high intensity training and that changes to the format of middle distance running performance in adolescent competition are recommended.

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Carter, Lindsay G. « Offspring and Maternal Health Benefits of Exercise during Pregnancy ». UKnowledge, 2013. http://uknowledge.uky.edu/nutrisci_etds/6.

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Maternal lifestyle and nutrient intake during pregnancy can have long-lasting effects on the health of offspring as well as the mother. This dissertation focuses on the impact of maternal exercise during pregnancy on offspring insulin sensitivity and glucose uptake and the maternal effects of exercise during pregnancy. The first aim of this dissertation was to investigate if exercise prior to and during pregnancy and nursing would improve glucose uptake and insulin sensitivity in mice and rats. In both mice and rats, it was concluded that maternal exercise could enhance whole-body insulin sensitivity and increase glucose uptake into skeletal muscle and adipose tissue in adult offspring compared with offspring from sedentary dams. Maternal exercise also positively influenced male but not female adult offspring body composition; male offspring from exercised dams had significantly decreased fat mass and increased lean mass compared with offspring from sedentary dams. The second aim of this dissertation was to test whether exercise during pregnancy would improve glucose disposal in mouse dams with diet-induced obesity. Maternal running was effective in reducing fat mass accumulation and glucose intolerance associated with high fat feeding during pregnancy. In high fat diet mice, exercise was also able to improve insulin sensitivity in adipose tissue compared to tissue from sedentary high fat diet mice. The findings in this dissertation provide new insight into the long-term effects exercise during pregnancy can have on offspring health. Women may be encouraged to start an exercise regimen before and during their pregnancy if they are aware of the life-long benefits it can have for their children. The findings from the second aim present new insight into how exercise can affect pregnancies complicated by maternal obesity and glucose intolerance, and the animal model can be used in the future studies to investigate the offspring effects of maternal exercise during a diabetic pregnancy.

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Parkinson, Joel T. « Functional connectivity as a biomarker for depression : effects of physical exercise and electroconvulsive therapy ». Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236195.

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Conventional treatments for depression, such as pharmacological interventions, are often ineffective. Up to half of patients do not respond, resulting in a poor prognosis for depression. Therefore, treatment options can be invaluable for increasing rates of remission. It is generally assumed that aerobic exercise benefits affective state. However, exercise remains a controversial treatment, possibly due to inconsistent evidence and unknown mechanisms. It is hypothesised variable results (literature is conflicting) are due to/because of heterogeneity in exercise interventions and subjective reports of exercise and mood state. If a biomarker for depression can be identified, the effects of exercise on depression could be objectively assessed. Neuroimaging research has elucidated numerous biomarkers, but has had little benefit on the diagnosis, prognosis or treatment of depression. However, if research can identify which biomarkers respond to treatments, can stratify patients and which can predict response outcome, targets for new interventions can be developed. Therefore, this thesis first establishes the effect of ECT treatment on emotionally salient brain regions in MDD, establishing the basis of a treatment responsive biomarker and potential targets for other interventions. The same functional connectivity methods are then used to analyse the effects of a single bout of aerobic exercise in a healthy population. Similar reductions in functional connectivity were observed in brain structures relevant to depression, suggesting exercise might target relevant brain structures. Finally, using the same functional connectivity methods, a long-term aerobic exercise intervention is shown to reduce functional hyperconnectivity in mildly depressed participants compared to healthy controls. This supports two primary hypotheses: that hyperconnectivity may underlie depressive disorders, constituting a biomarker for depression; and that aerobic exercise is an effective treatment for milder forms of depression.

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Taivassalo, Tanja. « Exercise training as therapy for mitochondrial myopathies : physiological, biochemical and genetic effects ». Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37845.

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Patients with mitochondrial myopathies characteristically exhibit pronounced exercise intolerance, often associated with lactic acidosis, tachycardia and muscle weakness. These clinical features are attributable to impaired electron transport chain function in skeletal muscle. The usual etiology is a primary defect in mitochondrial DNA (mtDNA), where the severity of impairment is presumably linked to the ratio of mutant to wild-type mtDNA. This dissertation presents novel therapeutic approaches to these genetic defects, aimed at attenuating mitochondrial dysfunction and ameliorating the clinical condition by employing exercise training alone or in conjunction with pharmacological therapy. Dichloroacetate (DCA) was administered to augment mitochondrial capacity by activating pyruvate dehydrogenase, thereby decreasing lactic acidosis. Endurance and resistance training paradigms were employed to induce mitochondrial and satellite cell proliferation respectively. The goals were to augment respiratory chain function, increase levels of wild type mtDNA, and reverse effects of chronic inactivity. The effects of these treatments on functional and mitochondrial capacity were defined by changes in: (1) work capacity, oxygen utilization, and circulatory responses during maximal exercise; (2) heart rate and blood lactate during submaximal exercise; (3) recovery kinetics of phosphate-containing metabolites measured using phosphorus magnetic resonance spectroscopy ( 31P MRS); (4) scores on a quality of life questionnaire. The cellular correlates for these indices were defined by changes in: (1) mitochondrial volume, (2) respiratory chain enzyme activity, and (3) levels of mutant/wild-type mtDNA. Although DCA administration alone lowered blood lactate, endurance training was more effective in improving exercise capacity, heart rate and blood lactate, 31P MRS recovery kinetics, and quality of life. Increased mitochondrial volume and respiratory chain function were closely linked

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Pereira, Mariana Aparecida de Alencar Jeronymo Simão [UNESP]. « Avaliação das concentrações séricas de lactato, creatina quinase, aspartato aminotransferase, lactato desidrogenase, parâmetros clínicos e hematológicos de equinos Quarto de Milha submetidos à prova de laço em dupla ». Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132430.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O objetivo do trabalho foi avaliar a influência de diferentes frequências de treinamento sobre as concentrações séricas de lactato, CK, AST e LDH e sobre os parâmetros clínicos e hematológicos de equinos após exercício físico de alta intensidade e curta duração. Amostras de sangue venoso foram obtidas de 16 equinos da raça Quarto de Milha, divididos em dois grupos: grupo de treinamento regular (GTR) e grupo de treinamento esporádico (GTE), em sete diferentes momentos: 30 minutos antes do exercício (M0), imediatamente após (M1), 30 minutos (M2), uma (M3), duas (M4), seis (M5) e 24 (M6) horas após o exercício. Diferenças entre os grupos foram observadas em relação ao VG, à concentração de hemoglobina, ao VCM e ao número de linfócitos, inclusive no repouso. Entre os momentos, no GTE foram observadas diferenças significativas após o exercício quanto ao lactato, VG, PPT, número de granulócitos e LDH e no GTR quanto ao VG, contagem total de hemácia, concentração de hemoglobina e LDH. Conclui-se que os equinos avaliados apresentaram alterações nas concentrações séricas de lactato e enzimas musculares e nos parâmetros clínicos e hematológicos após o exercício. A menor magnitude de elevação após o exercício, observada no GTR, quanto às FC, FR e ao VG sugere que esses animais estariam melhor adaptados ao exercício imposto. A baixa magnitude das elevações das concentrações de CK, AST e LDH e o rápido retorno aos valores basais, inclusive do lactato, das FC e FR e dos parâmetros hematológicos, sugerem que os animais avaliados estavam condicionados e aptos a realizar o tipo de exercício estabelecido, não havendo diferença entre o treinamento regular e o treinamento esporádico.
The objective was to evaluate the influence of different frequencies of training on serum concentrations of lactate, CK, AST and LDH and on clinical and hematological parameters of horses after exercise of high intensity and short duration. Venous blood samples were obtained from 16 Quarter Horses, divided into two groups: regular training group (GTR) and sporadic training group (GTE) in seven different times: 30 minutes before exercise (M0), immediately after (M1), 30 minutes (M2), one (M3), two (M4), six (M5) and 24 (M6) hours after exercise. Differences between groups were observed in VG, hemoglobin concentration, VCM and number of lymphocytes, including on resting. Between the moments, in GTE significant differences were observed after exercise for lactate, VG, PPT, granulocyte number and LDH and in GTR for VG, total count of red blood cells, hemoglobin concentration and LDH. We conclude that the assessed horses showed changes in serum concentrations of lactate and muscle enzymes and in clinical and hematological parameters after exercise. The lower magnitude of elevation after exercise, observed in GTR, for HR, RR and VG suggests that these animals were better adapted to exercise. The low magnitude of elevations of CK, AST and LDH concentrations and the rapid return to baseline, including lactate, HR, RR and hematological parameters suggest that evaluated animals were conditioned and able to perform the established type of exercise, with no difference between regular training and the sporadic training.
FAPESP: 2014/09362-5

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Jones, Angela Jane. « Normal and diseased equine digital flexor tendon : blood flow, biochemical and serological studies ». Thesis, Royal Veterinary College (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324895.

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Wootten, David F. « Short Term Time Course Skeletal Responses to High Intensity Physical Exercise ». Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27880.

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The purpose of this randomized controlled trial was to investigate temporal skeletal responses to short-term high intensity physical activity. Twenty-eight normal active females [age: 20.7 +/- 2.1 yr (mean +/- SD)] were randomized into exercise (EX, n = 15) or control (CN, n = 13) groups. The exercise group trained 6 days/wk for 6 wk, which consisted of maximal isokinetic knee flexion/extension 3 days/wk, combined with 3 days/wk running. The purpose was to expose the tibiae to a period of abruptly increased loading forces. Tibial bending stiffness (EIMRTA), and serum concentrations of biochemical markers of bone formation [osteocalcin (OC)], and bone resorption [n-telopeptide of type I collagen (NTx)] were measured at baseline, 2 wks, 4 wks, and 6 wks. Isokinetic concentric knee extension/flexion peak torque, as well as total body and site-specific bone mineral density (BMD) were measured at baseline and 6 wk. After training, the exercise group significantly increased (p < 0.05) isokinetic concentric peak torque for the dominant (13.6%) and non-dominant (5.7%) quadriceps, as well as dominant (7.7%) and non-dominant (9.5%) hamstrings, compared to the controls. No differences for total body or site-specific BMD were noted. A two-way multivariate repeated measures ANOVA revealed no timeâ ¢group interactions for composite tibial bending stiffness [(EIMRTA); p = 0.57] or the biochemical markers of bone turnover [(OC and NTx); p = 0.15] across the four sampling periods. While there were no main effects for group, a trend for time (p = 0.051) for composite EIMRTA was observed. The exercise group demonstrated a 20% increase in EIMRTA from baseline (74.8 +/- 22.3 Nm2) to 6 wk (89.8 +/- 24 Nm2), compared to controls who demonstrated a 4% increase (Baseline 86.5 +/- 23.8 Nm2; 6 wk 90 +/- 23.7 Nm2). Significant group differences (p = 0.05) were noted for OC, but not NTx. Differences (p < 0.05) for OC were observed at baseline [13.2 +/- 2.4 ng/ml (CN), 15.6 +/- 2.7 ng/ml (EX)], and follow-up ANCOVA revealed no differences for subsequent sampling periods. Main effects for time were found for OC and NTx (p < 0.001). Main effects for time in OC were attributable to changes in the exercise group (p < 0.01) and NTx (p < 0.01), but not the control group.
Ph. D.

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Ho, Thanh C. « Metabolic and biochemical responses during sustained forearm exercise in patients with chronic fatigue syndrome / ». Title page and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09SB/09sbh678.pdf.

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Thesis (B. Sc.(Hons.))--University of Adelaide, Dept. of Physiology, 1998?
Spine title: Metabolic responses during exercise in patients with chronic fatigue syndrome. Includes bibliographical references (leaves 14-16).

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Lam, Man-kin. « A cross-sectional study of leisure-time physical activity prevalence and its association with cardiovascular biochemical risk factors in Hong Kong ». Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25101353.

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Murphy, Margaret O'Bryan. « The Role of Exercise in Polychlorinated Biphenyl Induced Cardiovascular Disease ». UKnowledge, 2014. http://uknowledge.uky.edu/nutrisci_etds/13.

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Cardiovascular disease remains the leading cause of death in Western societies. Endothelial dysfunction is one of the initiating steps in the development of atherosclerosis. While there is a strong correlation with a person’s genetics, lifestyle factors including smoking, physical activity, and diet can significantly increase a person’s susceptibility to the development of atherosclerosis. In addition to these lifestyle factors, there is a strong body of evidence linking exposure to environmental pollutants including persistent organic pollutants such as polychlorinated biphenyls to increased cardiovascular disease and mortality. It has been well-established that exercise protects against cardiovascular disease, but whether exercise can modulate PCB-induced cardiovascular inflammation and dysfunction is unknown. To investigate the effects of exercise on PCB-induced cardiovascular disease, two murine models of atherosclerosis, the ApoE-/- and the LDLr-/- mouse were utilized. Risk factors for cardiovascular disease including adiposity, glucose intolerance, hyperlipidemia, hypertension, oxidative stress, and inflammation, were assessed in these two models as well as mean atherosclerotic lesion size. Exercise positively modulates several risk factors associated with cardiovascular disease including hypertension, hyperlipidemia, adiposity and obesity, systemic levels of oxidative stress, inflammation, and glucose tolerance. Exercise significantly reduced mean lesion size in vehicle-treated animals. To assess the mechanism of protection of exercise in chapter 4, vascular reactivity studies were performed to measure endothelial function after exposure to PCB 77. Exercise prevented PCB-impaired endothelial function implicating the role of superoxide as a cause of impairment. Exercise upregulated phase II antioxidant enzymes. The work in this dissertation demonstrates several protective properties of exercise against PCB-induced cardiovascular disease; however, additional studies are needed to determine if exercise enhances metabolism and excretion of these environmental pollutants.

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Brown, Malcolm. « The acute effects of exercise and postprandial hypertriglyceridemia on physiological and biochemical risk factors for disease ». Thesis, Ulster University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701436.

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Oxidative stress is an integral component in the pathology of cardiovascular disease, the leading cause of global mortality. Metabolic disturbances observed during postprandial hypertriglyceridemia have been identified as an independent risk factor within the aetiology of this disease, mainly via oxidative stress and pro-inflammatory mechanisms. Physical exercise has shown promising signs in ameliorating the symptoms of cardiovascular disease, but its role in the generation of oxidative stress, inflammation and associated molecular damage to lipids, protein and DNA is not fully understood. The principal aim of this thesis is to examine the transient effects of differing walking exercise trials on free radical metabolism, inflammation and subsequent molecular damage over time, in conditions of fasting and metabolic disturbance.

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Karlsson, Linn. « Chronic Pain and Exercise : Studies on pain intensity, biochemistry, adherence and attitudes ». Doctoral thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137076.

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Chronic pain is common in western countries and entails considerable consequences for the afflicted individuals as well as for the society. Furthermore, chronic pain is complex including an advanced interplay between biological-, psychological- and social aspects. Treatment of chronic pain attempts to decrease pain intensity and increase physical-, psychological- and social functioning. However, the treatment of chronic pain is still not optimized. Different types of physical activity and exercise (PA&E) are commonly applied as non-pharmacological treatment strategies for chronic pain, but the most efficient type and dose of PA&E are unclear. In addition, adherence to prescribed PA&E is often troublesome, which further complicates the application of PA&E as treatment for chronic pain. The aim of this thesis is to increase the knowledge about PA&E as treatment for chronic pain regarding pain intensity, biochemical substances, adherence and attitudes. The findings of this thesis were that a long-term, home-based PA&E intervention comprising strength exercises as well as stretch exercises decreased pain intensity and increased function in women with chronic neck- and shoulder pain. Using microdialysis technique, differences in pain modulatory biochemical substances were found, before the intervention, in painful trapezius muscle compared to pain-free trapezius muscle. In addition, alterations in pain modulatory substances in painful trapezius muscle after the intervention were found, which possibly could imply peripheral physiological effects of PA&E. Furthermore, psychological factors could be associated to the effects of and adherence to the PA&E intervention. An intention to be physically active were expressed by patients with chronic pain, but a discordance between the intention and PA&E-behaviour were evident, even though the PA&E were experienced as valuable. In conclusion, this thesis strengthens the importance of PA&E as treatment for chronic pain. Especially, this thesis increases the knowledge about; possible peripheral pain inhibitory effects after long-term exercise; how psychological factors might affect the results of PA&E; and also about important behavioural aspects that might affect adherence to prescribed PA&E. This thesis highlights the need of more research on physiological pain inhibitory effects of long-term PA&E in chronic pain. Furthermore, improved methods for ensured adherence to prescribed PA&E are necessary in order to optimize the effect of PA&E as treatment for chronic pain.

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Cherry, Paul Warren. « Influence of average pedalling rate upon the magnitude of the mechanical and biochemical changes arising from high-intensity exercise ». Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/33061.

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The process of fatigue during 30 s of high-intensity exercise results in rapid and substantial mechanical, electrical and biochemical changes in muscle fibres. This thesis describes a series of experiments, performed upon a friction-loaded cycle ergometer, which investigated whether the magnitude of the mechanical and biochemical changes is affected by changes in average pedalling rate. The ability to generate peak power in a subsequent sprint of 6 s duration was used to assess the magnitude of the mechanical changes. Changes in the concentrations of blood and muscle metabolites pre- and post-exercise permitted some of the biochemical changes to be measured.

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Li, Xihua. « Alterations in Histochemical and Biochemical Properties of Cardiac and Skeletal Muscles to Endurance Exercise Following Myocardial Infarction in Rats ». Kyoto University, 2001. http://hdl.handle.net/2433/150750.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(人間・環境学)
甲第9035号
人博第128号
12||130(吉田南総合図書館)
新制||人||31(附属図書館)
UT51-2001-F365
京都大学大学院人間・環境学研究科人間・環境学専攻
(主査)教授田口貞善, 教授森谷敏夫, 助教授小田伸午, 講師野原隆司
学位規則第4条第1項該当

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林文健 et Man-kin Lam. « A cross-sectional study of leisure-time physical activity prevalence and its association with cardiovascular biochemical risk factors inHong Kong ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970631.

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Peterson, Jonathan M., Ryan Mart et Cherie E. Bond. « Effect of Obesity and Exercise on the Expression of the Novel Myokines, Myonectin and Fibronectin Type III Domain Containing 5 ». Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/71.

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Metabolic dysfunction in skeletal muscle is a major contributor to the development of type 2 diabetes. Endurance exercise training has long been established as an effective means to directly restore skeletal muscle glucose and lipid uptake and metabolism. However, in addition to the direct effects of skeletal muscle on glucose and lipids, there is renewed interest in the ability of skeletal muscle to coordinate metabolic activity of other tissues, such as adipose tissue and liver. The purpose of this study was to examine the effects of endurance exercise on the expression level of two novel muscle-derived secreted factors, or myokines, Myonectin and Fibronectin type III domain containing 5 (FNDC5), the precursor for Irisin. Methods. We performed immunoblot analysis and quantitative real-time PCR analysis of Myonectin and FNDC5 in the diaphragm muscles of obese Zucker rat (OZR) and lean Zucker rat (LZR) with 9 weeks of aerobic training on a motorized treadmill. Results. We show that myonectin gene expression is increased in the OZR model of obesity and decreases with exercise in both lean and obese Zucker rats. Conversely, myonectin protein concentration was elevated with exercise. Similarly, FNDC5 mRNA levels are significantly higher in the OZR, however exercise training had no effect on the expression level of FNDC5 in either the LZR or OZR. We did not observe any difference in muscle protein content of Irisin with obesity or exercise. Conclusion. Our data shows that exercise training does not increase either FNDC5 or myonectin gene expression, indicating that increased transcriptional regulation of these myokines is not induced by exercise. However, our data also indicates a yet to be explored disconnect between myonectin gene expression and protein content. Further, this report highlights the importance of verifying reference genes when completing gene expression analysis. We found that many commonly used reference genes varied significantly by obesity and/or exercise and would have skewed the results of this study if used to normalize gene expression data. The unstable reference genes include: beta-Actin, beta-2-microglobulin, Non-POU domain containing, octamer-binding, Peptidylprolyl isomerase H, 18S ribosomal RNA, TATA box binding protein and Transferrin receptor.

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Abbott, Rebecca A. « Physical activity in childhood and its relation to biochemical and physiological markers of cardiovascular health ». Thesis, Queensland University of Technology, 2000. https://eprints.qut.edu.au/36776/1/36776_Digitised%20Thesis.pdf.

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There is considerable concern, worldwide, that the current lifestyles that children lead are placing them at increased risk of a range of adult diseases later in life, as well as having more immediate short-term consequences for their health. Of particular concern is the concept that children are becoming more sedentary and less physically active. The importance, in adulthood, of regular and appropriate physical activity with regards to health has been convincingly shown. In particular, individuals who are more active are less likely to develop coronary heart diseases and cerebrovascular disease. When combined these account for the major cause of death in Australia and developed countries across the world. With the knowledge that physical activity patterns developed in childhood carry through into adulthood, declining activity levels in the first two decades of life could clearly have strong implications for subsequent health. In the short term, reduced physical activity has been linked with a worsening cardiovascular risk profile. However the exact relationship of physical activity with risk factors is not clear due to the inconsistent and varied methodologies used to determine physical activity. This thesis therefore, investigated physical activity levels in 6.0 to 10.5 year old children by a number of techniques, which ranged from the accurate measurement of total energy expenditure through to the more subjective assessment by diary and questionnaire. The parameters of activity were then related to both novel and standard markers of cardiovascular risk, in particular flow-mediated dilation - a measure of arterial health. Total energy expenditure levels and time spent in moderate to vigorous intense physical activity matched published recommendations. Furthermore, as a group, the children had habitual physical activity levels that categorised the children as moderately active. However, both habitual physical activity and intensity of activity were positively related to endothelial function. In addition, increasing levels of habitual activity and intense physical activity were inversely related to both percentage body fat and an unfavourable blood lipid profile. This research showed that although the children were moderately active, reduced physical activity was associated with increased cardiovascular risk, even at this young age.

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Lindsay, Angus John Chisholm. « Acute and chronic individualised psychophysiological stress assessment of elite athletes through non-invasive biochemical analysis ». Thesis, University of Canterbury. School of Biological Sciences, 2015. http://hdl.handle.net/10092/10737.

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Intense exercise is known to cause alterations in the psychophysiological status of an athlete. Monitoring the health and recovery of an athlete is imperative for the maintenance of performance and reduced fatigue and injury incidence. The physicality associated with select sports results in significant elevations and suppression of psychophysiological biomarkers that are often modulated by game-related impacts, intense training regimes and psychosocial aspects associated with the professional era. The aim of the studies outlined in this thesis were to determine the effectiveness of selected “stress” markers in several sports that result in significant “stress”, and quantify the level of acute and chronic “stress” following individual games and competitions to improve athlete management and recovery. Study one aimed at developing a new strong-cation exchange high performance liquid chromatography (SCX-HPLC) method for the detection and quantification of urinary pterins and creatinine in a body-building cohort completing high intensity resistance training. The method had an intra- and inter-assay variability of 3.04 % and 5.42 % respectively, with visibly clear peaks and no tailing. Urinary neopterin (NP) and 7,8-dihydroneopterin during a week of competitive natural body-building did not significantly change indicating no alteration in immune system function and oxidative stress. It did provide evidence for the use of specific gravity as a similarly reliable method for urine volume correction following exercise. Study two focused on a playoff game of elite amateur rugby. The time course changes of NP, cortisol, salivary immunoglobulin A (sIgA) and myoglobin in 11 elite amateur rugby players were measured up to 86 hours post-game. Cortisol increased 4-fold, myoglobin 2.85-fold, NP 1.75-fold and total NP 2.3-fold, all significant, whilst sIgA did not change. All markers returned to baseline within 17 hours providing valuable information for sample collection schedule optimization. Respiratory elastance was also measured by ventilation for the assessment of exercise induced lung inflammation/injury following the game (Chapter three). There was an increase in elastance in selected individuals that did not correlate with either global positioning system (GPS) or impact data. It was shown however, that a ventilator is capable of measuring respiratory changes in a conscious and healthy individual. Study three focused on the final three games of professional rugby in the 2013 ITM Cup. The acute and cumulative changes in the same four markers were analysed following three home games. There were significant increases in NP, total NP, cortisol and myoglobin along with significant suppression of sIgA (p < 0.05). Large intra- and inter-individual variation existed between players with changes associated with total impacts. Moreover, impact induced muscle damage may account for changes in oxidative status. Specific gravity (SG) was shown to be a more reliable marker for urine volume correction in comparison to creatinine; while some players showed signs of cumulative stress. Study four examined stress in a professional team throughout the 22 week 2014 Super 15 competition. Part one investigated changes in oxidative stress and muscle damage markers to solidify the muscle damage/oxidative status theory postulated in the previous study. Experimental evidence showed iron and myoglobin are separately capable of oxidizing 7,8-dihydroneopterin to NP in vitro. It was then identified that players who suffered the greatest muscle damage as a result of impacts also had the greatest change in oxidative status (NP). This evidence suggests rugby union induces significant alterations in oxidative status that may be exacerbated by the impact induced release of myoglobin. Part two measured urinary NT-proBNP during the last two consecutive home games to identify whether rugby union causes significant cardiovascular stress and if the pre to post-game change can be explained by GPS technology. Significant individualized elevations were observed in games one and two which did not correlate with any GPS measurements or impacts. Concentrations returned to normal ~ 36 hours post-game suggesting no permanent damage to cardiac muscle had occurred. The lack of correlation suggests GPS technology is not an accurate measure of cardiovascular stress in professional rugby union. Part three involved the measurement of cortisol, total NP and sIgA throughout the season to assess the degree of cumulative stress. Samples were taken at regular intervals ~ 36 hours post-game for 22 weeks. Extreme inter-individual variation was present. Select individuals showed continual elevation in immune system activation and psychophysiological stress, whilst others presented with a continual decline in immune system function. Collectively however, minor deviations from baseline in all markers were observed and participation in long distance travel did not significantly affect the psychophysiological status of the group. Together this suggests a season does not cause an accumulation in psychophysiological stress, although careful individual player analysis is warranted. Understanding rugby union positional demands is essential for training program specification and position specific development of players. Part four used GPS, video-analysis and biochemical analysis to identify positional demands in five regular season games. Forwards tended to be involved in more impacts and covered less distance, while backs covered more distance and carried the ball into contact more regularly. There was no difference in the psychophysiological status between positions indicating both aspects of stress (impacts and distance covered) may induce a similar response. Alternatively, individual biological variation may be solely responsible for this change suggesting careful consideration should be given when using traditional work-load measures such as GPS when quantifying “stress”. Part five assessed the effectiveness of varied recovery interventions. Total NP, cortisol, myoglobin and sIgA were measured pre- post- and ~ 36 hours post game to identify which intervention was most effective at returning players to a psychophysiological state that allowed for the resumption of normal training. Findings concluded the immediate post-game strategy employed by the team (cold bath, consumption of protein and carbohydrates, compression garments and eight hours sleep) seemed to provide the greatest psychophysiological improvement regardless of the “next-day” intervention. There was large inter-individual variation and players were still in a state of recovery ~ 36 hours post-game as indicated by the elevated total NP and sIgA concentrations. Study five had four aspects. Develop a new, cost-effective and simple reverse phase HPLC (RP-HPLC) method for the quantification of urinary myoglobin in a clinically relevant range, quantify the level of structural stress following a simulated mixed martial arts (MMA) contest, determine whether cold water immersion attenuates the level of inflammation and muscle damage following a contest, and whether this hypothesized attenuation may be explained by cryotherapy induced mononuclear cell activation suppression in vitro. The RP-HPLC method had an intra- and inter-assay variations from 0.32 - 2.94 %. Linearity was in the range of 5 – 1000 µg/mL which detected significant increases in urinary myoglobin following the MMA contest. Total NP was found to significantly increase following the contest and return to approximately pre-contest levels 24 hours later for the passive group only. Cold water immersion was further found to attenuate the total NP increase in the first two hours post-contest solidifying its use as a recovery technique following intense exercise, while cryotherapy significantly suppressed T-cell activation. This study provides a reliable and repeatable assay for muscle damage quantification in a clinically relevant range, evidence of the physicality associated with MMA, and indicates cold water immersion is a reliable recovery intervention that may impart its positive benefits through T-cell suppression. The data generated by these investigations highlights the necessity for individual physiological analysis. Group data often masks the extreme variation that exists in clinical and exercise trials where treatment and management of athletes is conducted for recovery and performance. Biochemical analysis provides an added sophistication of work-load and psychophysiological assessment that common technological methods cannot emulate. With a lack of correlation between the quantitative changes in specific non-overlapping biomarkers and GPS, video-analysis and questionnaires, it would seem pertinent to develop a non-invasive quantitative approach in elite sport to understand the level of exercise-induced psychophysiological stress for the precise management of athletes.

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Ana, Marijanac. « Uticaj modela programa vežbanja na koštanu gustinu i biohemijske markere koštanog remodelovanja kod žena u pre- i postmenopauzi ». Phd thesis, Univerzitet u Novom Sadu, Fakultet sporta i fizičkog vaspitanja u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107239&source=NDLTD&language=en.

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Generalni cilj ovog istraživanja je da se utvrdi da li postoji uticaj primenjenogprograma vežbanja na parametre koštane gustine i biohemijske markere koštanogremodelovanja kod žena u periodu premenopauze i postmenopauze.Uzorak ispitanica je činilo 26 žena starosti 45 do 55 godina, od kojih su 13 u periodupremenopauze, a 13 u periodu postmenopauze. Ispitanice su učestvovale u programu vežbanjau trajanju od 6 meseci, koji se realizovao u Novom Sadu, 4 puta nedeljno u trajanju od satvremena. Za utvrđivanje uticaja programa vežbanja na koštanu gustinu merena su 3osteodenzitometrijska parametra na kičmi, vratu butne kosti i kuku i 5 parametarabiohemijskih markera koštanog remodelovanja.Da bi se utvrdio uticaj vežbanja kod ispitanica, primenjena je multivarijatna analizevarijanse (MANOVA). Na celokupnom uzorku ispitanica nije utvrđena statistički značajnarazlika ni u jednom merenom parametru koštane gustine. U odnosu na biohemijske markere,došlo je do značajnog smanjenja nivoa ukupne alkalne fosfataze. Kod žena u periodupremenopauze i kod žena u periodu postmenopauze, program vežbanja nije značajno uticaona parametre koštane gustine merene na kičmi, vratu butne kosti i kuku (DXA, LunarProdrigy), kao ni na parametre biohemijskih markera koštanog remodelovanja.Primenom multivarijatne analize kovarijanse (MANCOVA) utvrđena je značajnarazlika u uticaju programa vežbanja između žena u pre- i postmenopauzi u mineralnojkoštanoj gustini vrata butne kosti (BMD VF) i markera beta-crosslaps (CTX). Mineralnakoštana gustina je nakon programa vežbanja veća, a nivo beta-crosslapsa niži kod žena upremenopauzi nego kod žena u periodu postmenopauze.Na osnovu dobijenih rezultata, zaključujemo da je potreban duži vremenski periodrealizacije programa vežbanja kako bi se mogla primetiti statistički značajna promenamerenih parametara. Ispitanicama se savetuje da nastave sa vežbanjem kako bi usporilegubitak kosti
The genaral aim of this research is to determine is there an effects of the applied exerciseprogram on bone mineral density and and biochemical markers of bone turnover in thepremenopausal and postmenopausal period.The sample was consisted of 26 women aged 45 to 55 years, of which 13 were inpremenopausal and 13 in postmenopausal period. Subjects were included (had performing) in 6-monthexercise program, which was implemented (maintained) in Novi Sad, 4 times a week in duration for anhour. Three osteodensitometric parameters on lumbar spine, femoral neck and hip (DXA, LunarProdrigy) and five parameters of biochemical markers of bone turnover were measured to assessed(to determine) the effects of exercise program on bone density.Multivariate analysis of variance (MANOVA) was used to determine the effect of exercise.For the entire sample of subjects, there were no statistically significant difference in any measuredbone density parameter, but looking at biochemical markers, total alkaline phosphatase level weresignificanly reduced. There were no significant changes in bone density parameters on the lumbarspine, femoral neck and hip nor on the parameters of biochemical markers of bone turnover in womenin premenopausal and postmenopausal period.Applying multivariate analyse of covariance it was found a significant difference in theexercise program effect between pre- and postmenopausal women in bone mineral density of femoralneck (BMD VF) and beta-crosslaps marker of turnover (CTX). Femoral neck BMD was higher, andbeta-crosslaps level was lower in premenopausal women than in postmenopausal women aftercompletion exercise program.Based on obtained results, we conclude that is required a longer perod of exercise programralization in order to notice a statistically significant change in measured parameters. Subjects areadvised to continue their exercising in order to slow down the bone loss

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Illera, Dominguez Victor. « Respuestas musculares agudas y crónicas del tren inferior al entrenamiento iso-inercial ». Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671590.

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El objetivo de esta tesis doctoral es el de identificar y caracterizar las respuestas agudas y crónicas del tren inferior ante sesiones de entrenamiento iso-inercial utilizando el ejercicio de media sentadilla. El documento está compuesto por cuatro estudios consecutivos. El Estudio 1 valora la validez de un codificador de fricción contra una medida criterio para proporcionar valores de fuerza, velocidad y potencia en el dispositivo de entrenamiento iso-inercial. Los resultados sugieren que el codificador de fricción proporciona medidas válidas de velocidad, fuerza y potencia. Este dispositivo es una solución para el control de sesiones de entrenamiento que permite proporcionar retroalimentación en vivo a los atletas día a día. El estudio 2 investiga los efectos agudos de una sesión de entrenamiento iso- inercial en diferentes indicadores de rendimiento, incluyendo sprint y salto, y la capacidad de generación de fuerza isométrica. La respuesta entre los participantes fue muy heterogénea, y algunos participantes mostraron signos de daño muscular moderado, que afectaron el rendimiento funcional hasta 72 horas después del ejercicio. Estos resultados destacan la necesidad de pruebas específicas para evaluar la disponibilidad y la recuperación tras las sesiones. El estudio 3 investiga los efectos crónicos de un programa estructurado de entrenamiento iso-inercial de 4 semanas sobre la función muscular y la hipertrofia (volumen total) medido por resonancia magnética. Los participantes mostraron grandes aumentos de volumen en el cuádriceps después de dos (+ 5.5%) y cuatro (+ 8.6%) semanas de entrenamiento. Estos resultados se acompañaron de aumentos en la fuerza (≈ 30% en cuatro semanas) y la potencia (≈ 50% en cuatro semanas) en la media sentadilla. También se observaron aumentos en la fuerza en el ejercicio de extensión de rodilla (+ 28%) después de cuatro semanas, pero no se observaron cambios en el ejercicio de flexión de rodilla. Este estudio reporta del inicio más temprano de hipertrofia de músculo completo documentado hasta la fecha (5 sesiones / 14 días). Finalmente, el Estudio 4 investiga el efecto protector conferido por las sesiones de entrenamiento iso-inercial contra el daño muscular causado por el ejercicio intenso. Los parámetros evaluados incluyen: fuerza isométrica, altura de salto vertical, dolor muscular y marcadores bioquímicos sanguíneos de daño muscular (p. Ej., Creatina quinasa, creatina quinasa mitocondrial sarcomérica, creatina quinasa isoforma MB, aspartato aminotransferasa, alanina aminotransferasa, titina y troponina cardíaca I). A pesar de realizar cargas de trabajo mucho más altas después del período de entrenamiento (+ 38.9%, + 21.0% y + 65.3% de producción de fuerza concéntrica, velocidad y potencia, respectivamente), todos los marcadores de daño muscular se atenuaron y los procesos de recuperación fueron más rápidos (El índice de protección varió del 75.4% al 79.7% para los parámetros de función muscular, del 52.5% al 85.5% para los marcadores bioquímicos sanguíneos y fue del 48.0% para el dolor muscular).
In this doctoral thesis, I aim to identify and characterise the acute and chronic responses of the lower limbs to iso-inertial training sessions using the half-squat exercise. The document is composed of four consecutive studies. Study 1 investigates the validity of a friction encoder against a criterion measure at providing force, velocity and power measures on the iso-inertial resistance training device. The results suggest that the friction encoder provides valid measures of velocity, force and power on flywheel exercise devices. Such a device is a solution for the control of training sessions which can provide athletes with live-augmented feedback on a day by day basis. Study 2 investigates the acute effects of an iso-inertial training session on different indicators of performance. These indicators include sprint and jump performance, and isometric force generating capacity. The response of the participants was highly heterogeneous, with some showing signs of moderate muscle damage that affected functional performance until 72 hours post exercise. These results highlight the need for specific tests for assessing readiness and recovery after sessions. Study 3 investigates the chronic effects of a structured 4-week iso-inertial training programme on muscle function and hypertrophy (total volume) measured by magnetic resonance imaging (MRI). Participants showed great increases in quadriceps volume after two (+ 5.5%) and four (+ 8.6%) weeks of training. These results were accompanied by increases in half-squat force (≈ 30% over four weeks) and power (≈ 50% over four weeks). Increases in strength were also seen in knee extensor exercise (+ 28%) after four weeks, but no changes were seen in knee flexor exercise. This study reports the earliest onset of whole-muscle hypertrophy documented to date (5 sessions / 14 days). Finally, Study 4 investigates the protective effect conferred by iso-inertial training sessions against muscle damage from intense exercise. The parameters assessed include: isometric force, vertical jump height, muscle soreness, and blood biochemical markers of muscle damage (Creatine kinase, sarcomeric mitochondrial creatine kinase, creatine kinase MB isoform, aspartate aminotransferase, alanine aminotransferase, titin, and cardiac troponin I). Despite performing much higher workloads after the training period (+38.9%, +21.0%, and +65.3% in production of concentric force, velocity, and power, respectively), all markers of muscle damage were attenuated, and the recovery processes were faster (the index of protection ranged from 75.4% to 79.7% for the muscle function parameters and from 52.5% to 85.5% for blood biochemical markers: and was 48.0% for muscle soreness).

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INNOCENTI, GIOVANNI, et F. Schena. « From biology to training : basis and mechanisms of peak-performance in gymnastics and impact with other sports ». Doctoral thesis, 2015. http://hdl.handle.net/2158/1003945.

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Previous studies: starting point. Aim: training optimization to grow from Talent to Peak Performance. SEARCH → Recruitment → Detection and discovery; DIAGNOSIS → Identification and validation → Goodwill; PROGNOSIS → Development, maintenance and control → Selection; Dosage and methodological; TREATMENT → Strengthening care. SUBJECTS FOR THE STUDIES: 16 athletes (gymnasts Team FGI / Olympic Club CONI). Average age: 20 years (± 4,17). DATA ALREADY KNOWN: genotype; history; athletic and physical parameters; performance indicators. MONITORED FOR: training plans and technical control. PERIOD OF INVESTAGATION: 2013 - 2015, still TEST EVENT qualifying final OG. THIS POJECT WORK WILL BE DEVELOPED INTO FOLLOWING FOUR OPERATIVE SECTIONS. I study: Biological Survey. Task: monitor also try to do it or how, any DNA methylation and histone modifications, which lead to persistent effects on the availability of DNA for transcription. Goal: induced a result of special agents such as nutrition, nutraceuticals, nutrigenomics/genetic and stress factors. II study: Training to peak performance. Task: implementation and monitoring of the new system of performance gymnastics workout through specific experimental protocols intake on the field. Goal: surveying methods, control, adjustment and validation shall be those provided by the FIG and therefore relevant to so-called "International Standard” for a peak performance in male artistic gymnastics. III study: Time related muscle adaptations. Task: evaluation of different dimensions of phenomena that characterize, from time to time, all the “adaptation to performance" caused by the administration of loads (chronic) and overloads (acute). Goal: definition of the specific time related of changes after high intensity training including the phenomena of repairs after ‘regular’ damages producing by strenous exercise (vigorous eccentric muscle contraction). IV study: Training load analysis. Task: analysis of the specific effects of the training loads on muscle morphology and functions with relationship to the technical performance Goal: to meet the three main factors for the conditioning of high level performance, namely the "Olympic Records".

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Carrabre, James Emmett. « Biochemical markers of eccentrically aerobic induced post exercise muscle soreness ». 1986. http://hdl.handle.net/1993/15358.

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YU, CHENG PEI, et 鄭培毓. « Effects of Exercise Intervention on Physical activity, Blood Biochemical Index and Exercise Self-Efficacy in patients during hemodialysis ». Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8682u6.

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碩士
美和科技大學
護理系健康照護碩士班
106
Abstract Background: The prevalence of end-stage renal disease was high, combined with the aging of dialysis, mortality and complication were relatively higher, hospitalization rate and medical expenses also increased. Dialysis patients‘s exercise habit is poor, exercise is beneficial to the patient's physiology and psychology. Providing safe and effective sports facilities, promoting the exercise self-efficac, and promoting the patient's continuous movement are very important issues. However, there are few studies incorporating simple bike into the patients’ exercise program in the clinical field. Therefore, the researcher would like to study how eight weeks exercise influence on the dialysis patients’ body activities, physiological indicators. At the same time, exercise self-efficacy. And providing nursing staffs refer to execute the patients’ exercise program in the clinical area. Purpose: The purpose of this study is to explore the effectiveness of exercise during dialysis on the dialysis patients’ body activities, biochemical indicators and exercise self-efficacy. Methods: Participants of this current experimental study were recruited from a reagional hospital in south Taiwan. Participants were randomly assigned to experimental group and control group. In experimental group, the patients rode bike for exercise during dialysis for eight weeks and the reasearcher and assistants recorded the patients’ body activities, biochemical indicators and exercise self-efficacy before and after exercise. SPSS software (version 23.0) was used to analyze the participants’ characteristics. T-test and 2-test was used to examine if the two groups have homogeneity. Then the participants’ body activities, biochemical indicators and exercise self-efficacy before and after exercise were compared by using paired t-test and ANCOVA was used to analyze the data of repeated measurements. Results: In this study, there are twentyeight persons in the experimental group and thirtyfive persons in the control group. Compared to control group, there were significant improvements in their body activities in the experimental group, such as eye open and stand on right foot (F=20.28, p<.001), sit down and reach test (F=12.64, p<.001), stand and sit for 20 seconds (F=22.213, p<.001), lift of knee test for 30 seconds (F=55.57, p<.001), waistline (F=11.779, p<.001). There are also significant improvements found in the experimental group on exercise self-efficacy. Kt/V、Phosphorum and blood sugar of the biochemical indicators were slightly improved in the experimental group but TG level of the experimental group was elevated. Conclusion: The results of this study showed that exercise in patients during hemodialysis can improve the physical activity of dialysis patients and enhance their self-efficacy. At the same time, the exercise is safe and effective in dialysis, which is suitable for further promotion. Hopefully, we can provide dialysis patients with relevant sports training toimprove their physical activities and enhance their quality of life.

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Ho, Ying-Chih, et 何應志. « The effects of glutamine supplementation on biochemical parameters of recovery after endurance exercise ». Thesis, 2007. http://ndltd.ncl.edu.tw/handle/26786182183087466597.

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博士
國立體育學院
體育研究所
95
This study investigated the effects of glutamine supplement on metabolic responses during recovery after endurance exercise. In this randomized, crossover study, seven healthy male judo athletes were randomly divided into two groups and performed a single bout of exercise at an estimated speed corresponding to the 75﹪VO2max for 60 min, and then, took either a placebo or glutamine at 0.1g/kg-wt. Blood samples of each athlete were collected before exercise, and 0, 15, 30, 45, 60, 90, 120 minutes after exercise, respectively. The experiment was repeated two weeks later, but treatments were exchanged for two groups. The concentrations of glucose, insulin, free fatty acid, glycerol, IL-6, lactate, ammonia, creatine kinase, and 19 amino aicds in blood were examined. No differences in the levels of glucose, insulin, lactate, ammonia, or creatine kinase between two groups were observed. Compared to the placebo group, the concentration of glycerol in the glutamine group was significantly lower at 45, 60, and 120-min recovery period, and the concentration of IL-6 was significantly higher at 30, 45, 60, and 120-min recovery period. In the concentration of blood amino acids, the glutamine concentration were significantly higher during the 120-min recovery period in glutamine group, and the alanine and glutamate concentration in glutamine group also show significantly higher at the 15-min recovery period. Furthermore, the BCAA concentration in glutamine group was lower at 45-min recovery period, and the phenylalanine and tyrosine concentration were lower at 120-min recovery period. The concentration of most amino acids in placebo group at 120-min recovery period were significant lower than pre-exercise, but only glutamate in glutamine group. The results indicate that glutamine supplement during exercise recovery period could inhibit the lipolysis, and induce the higher IL-6 level, and this make advantage to glucose utilization for body. Glutamine supplement also prevent the glutamine depletion, maintain the blood concentration of glutamine and other amino aicds after the endurance exercise, and high level of blood glutamine concentration may reduce the BCAA metabolism, decreased the proteolysis during the recovery period.

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劉鈞華. « Effects of Coenzyme Q10 Supplementation on Submaximal Exercise Induced Physiological and Biochemical Responses ». Thesis, 2004. http://ndltd.ncl.edu.tw/handle/50203781013501533828.

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碩士
中國文化大學
運動教練研究所
92
The purpose of this study was to investigate the effects of different dosageof coenzyme Q10 supplementation on the physiological response duringsubmaximal exercise bout and the blood biochemical response in recovery bout.Subjects were male students recruited from department of physical educationChinese Culture University (n = 8; age: 20.62 ± 1.69 yrs; height: 172.75 ± 6.65cm; weight: 63.25 ± 5.75 kg) . All subjects ingested placebo or different dosages of coenzyme Q10 at 2 mg/kg、3 mg/kg、4 mg/kg respectively every three days 6 hours prior to 30 minutes of 70％ VO2max exercise on cycle ergometer. Thecollected data was analyzed by Dependent ANOVA with a significance level ofα = .05. The result indicated that there was no effects of different dosagepre-supplementation Q10 on the oxygen uptake, ventilatory threshold, bloodpressure and heart rate during exercise bout, and on the blood lactate, creatinekinase (CK), bloodureanitrogen, triglyceride and cholesterol during recoverybout after exercise. Further study is required to examine the effects of coenzymeQ10 supplementation on aerobic exercise.

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WU, MENG-FANG, et 吳孟芳. « Effects of E-Cigarette Exposure on Exercise Performance and Biochemical Profile in Mice ». Thesis, 2017. http://ndltd.ncl.edu.tw/handle/97712579998538669882.

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碩士
國立體育大學
運動與健康科學學院
105
Electronic cigarettes (EC) are becoming a preferred replace for nicotine delivery among many smokers in recent year. In some research support that EC could be useful for smoking cessation. However, EC effects of on human health are inconclusive due to lack of empirical research investigating the presence of EC-induced health hazards or benefits. Thus, we examined the effect of vapor produced by EC on exercise performance and health-related profile in mice model. Female ICR mice were divided into 5 groups (n = 6 per group) for 14 days with no intervention, exposure in air, 0, 0.6mg/mL and 6mg/mL nicotine designated control, Air, ELN-0X, ELN‐1X and ELN‐10X groups, respectively. The results indicated that the EC decreased the grip strength (p = 0.0024) with ELN-10X. EC treatments also produced dose-dependent decreases in liver and muscle glycogen storage (p = 0.0009; p = 0.0003) with ELN-10X. In addition, EC treatment had no negative effect on levels of biochemical indices. We also found the major organ had no adverse effect on morphology. Therefore, we suggest that after use EC could reduce explosive force and glycogen storage capacity. In addition, we could not found any negative effect on biochemical profile and organ morphology.

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何應志. « The effects of glutamine supplementation on biochemical parameters of recovery after endurance exercise ». Thesis, 2007. http://ndltd.ncl.edu.tw/handle/93023987903211891648.

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博士
國立體育大學
體育研究所
95
This study investigated the effects of glutamine supplement on metabolic responses during recovery after endurance exercise. In this randomized, crossover study, seven healthy male judo athletes were randomly divided into two groups and performed a single bout of exercise at an estimated speed corresponding to the 75﹪VO2max for 60 min, and then, took either a placebo or glutamine at 0.1g/kg-wt. Blood samples of each athlete were collected before exercise, and 0, 15, 30, 45, 60, 90, 120 minutes after exercise, respectively. The experiment was repeated two weeks later, but treatments were exchanged for two groups. The concentrations of glucose, insulin, free fatty acid, glycerol, IL-6, lactate, ammonia, creatine kinase, and 19 amino aicds in blood were examined. No differences in the levels of glucose, insulin, lactate, ammonia, or creatine kinase between two groups were observed. Compared to the placebo group, the concentration of glycerol in the glutamine group was significantly lower at 45, 60, and 120-min recovery period, and the concentration of IL-6 was significantly higher at 30, 45, 60, and 120-min recovery period. In the concentration of blood amino acids, the glutamine concentration were significantly higher during the 120-min recovery period in glutamine group, and the alanine and glutamate concentration in glutamine group also show significantly higher at the 15-min recovery period. Furthermore, the BCAA concentration in glutamine group was lower at 45-min recovery period, and the phenylalanine and tyrosine concentration were lower at 120-min recovery period. The concentration of most amino acids in placebo group at 120-min recovery period were significant lower than pre-exercise, but only glutamate in glutamine group. The results indicate that glutamine supplement during exercise recovery period could inhibit the lipolysis, and induce the higher IL-6 level, and this make advantage to glucose utilization for body. Glutamine supplement also prevent the glutamine depletion, maintain the blood concentration of glutamine and other amino aicds after the endurance exercise, and high level of blood glutamine concentration may reduce the BCAA metabolism, decreased the proteolysis during the recovery period.

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36

Teixeira, Manuel António Cardoso. « Proteostasis, inflamatory and vasoactive biomarkers in patients with hypertension : effect of exercise training ». Master's thesis, 2018. http://hdl.handle.net/10773/25071.

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Background: Physical exercise is a consensual and well-established strategy to control blood pressure. Nonetheless, its effects on protein homeostasis in individuals with hypertension are not clearly defined. Aims: This study aimed to evaluate the effects of regular exercise on inflammatory, oxidative stress and vasoactive markers in circulation, as well as on protein homeostasis and quality of life in individuals with hypertension. Furthermore, we intended to correlate quality of life with the levels of the above-mentioned biomarkers. Methods: A total of 20 individuals with hypertension were recruited and divided into 2 groups of 10: a group who regularly participated in physical exercise (”EH”, age: 68.3 ± 4.2 years), and an age-matched group without regular exercise practice (“H”, age: 67.7 ± 5.1 years). Proteostasis and vasoactive markers were assessed in plasma using immunoblotting techniques (western blot or slot-blot) and Fourier-transform infrared spectroscopy (FTIR). The levels of ubiquitin, Hsp70, IL-6, C-reactive protein, TWEAK, IL-10, eNOS, endothelin-1, MMP-2, TIMP-2, connexin 43 and superoxide dismutase (SOD) were analysed by immunoblotting. Results: Significant higher levels of eNOS (p=0.011), Cx43 (p=0.020), TIMP-2 (p=0.038) and SOD-3 (p=0.001), with a fold increase of 1.2, 2.1, 1.3 and 1.2 respectively, were found in the EH group. The overall quality of life (60.1 ± 4.3 vs. 53.2 ± 5.9, p=0.009), as well as mental health (59.4 ± 7.9 vs. 50.7 ± 7.2, p=0.024) was significantly higher in the EH group. A strong inverse correlation was observed between the quality of life (total score of the SF-36) and the levels of IL-6 (r=-0.510, p=0.026). The levels of IL-6 are significantly higher in the H group (p=0.014), with a 1.5-fold increase in comparison with the EH group, and the analysis by FTIR showed high correlation between the levels of IL-6 and the 1500-900 cm-1 region of the infrared spectra, in which high levels of IL-6 are characterized by peaks related with collagen and low levels are related to carotenes. Multivariate analysis showed a good discrimination between the two groups in the 1500-900 cm-1 region (fingerprint region) and 1700-1600 cm-1 region (Amide I band). Furthermore, the H group showed peaks that are related with anti-parallel β-sheets, while EH group showed peaks related to parallel β-sheets and α-helices. Conclusion: Regular exercise participation reduced the circulating levels of the inflammatory biomarkers, increased the antioxidant defences and the levels of the vasodilator biomarkers and improved proteostasis and quality of life in individuals with hypertension.
Introdução: A prática regular de exercício físico é vista como uma estratégia terapêutica consensual no controlo da pressão arterial. No entanto, o seu efeito na homeostasia proteica em indivíduos com hipertensão ainda não está muito bem definido. Objetivo: Com este estudo pretendemos avaliar os efeitos da prática regular de exercício físico em biomarcadores vasoativos, inflamatórios e de stresse oxidativo presentes no plasma, assim como a homeostasia proteica e a qualidade de vida de adultos com hipertensão. Pretendemos também avaliar a correlação entre a qualidade de vida e os níveis dos marcadores acima mencionados. Métodos: Foram recrutados 20 indivíduos hipertensos, divididos em 2 grupos de 10: um grupo com indivíduos que praticavam regularmente exercício físico (grupo ”EH”, idade: 68,3 ± 4,2 anos), e um grupo com caraterísticas idênticas, mas sem prática regular de exercício (grupo “H”, idade: 67,7 ± 5,0 anos). A homeostasia proteica e os marcadores vasoativos foram avaliados através de técnicas de immunoblotting (western blot e slot blot) e da análise de Fourier-transform infrared spectroscopy (FTIR). Os níveis de ubiquitina, Hsp70, IL-6, proteína C-reativa, TWEAK, IL-10, eNOS, endotelina-1, MMP-2, TIMP-2, conexina 43 e SOD foram analisadas por immunoblotting. Resultados: O grupo EH apresentou níveis significativamente maiores de eNOS (p=0.011), Cx43 (p=0.020), TIMP-2 (p=0.038) e SOD-3 (p=0.001). A saúde mental (59.4 ± 7.9 vs. 50.7 ± 7.2, p=0.024) e a qualidade de vida geral (60.1 ± 4.3 vs. 53.2 ± 5.9, p=0.009) foram significativamente maiores no grupo EH. Os níveis de IL-6 foram significativamente maiores no grupo H (p=0.014), com um aumento de 1.5 vezes em relação ao grupo EH. Observou-se uma forte correlação inversa entre a qualidade de vida (pontuação total do SF-36) e os níveis de IL-6 (r=-0.510, p=0.026). A análise por FTIR permitiu correlacionar os níveis de IL-6 com a região 1500-900 cm-1 do espetro de infravermelhos, na qual elevados níveis de IL-6 são caraterizados pelas bandas relacionados com a acumulação de colagénio e níveis baixos estão relacionados com os níveis de carotenos. A análise multivariável permitiu diferenciar os dois grupos na região fingerprint (1500-900 cm-1) e na região da amida I (1700-1600 cm-1). O grupo H é caraterizado por picos relacionados com folhas-β anti-paralelas e o grupo EH é caraterizado por picos relacionados com folhas-β e α-hélices. Conclusão: A prática regular de exercício reduziu os níveis de biomarcadores inflamatórios em circulação, aumentou as defesas antioxidantes e os biomarcadores vasodilatadores, melhorando ainda a homeostasia proteica e a qualidade de vida de indivíduos com hipertensão.
FCT - PTDC/DTPPIC/5587/2014; Centro-01-0145-FEDER-000003
Mestrado em Biomedicina Molecular

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Lin, Shi-hui, et 林淑惠. « A Case Study on Biochemical Responses between 100-Km Running and Maximal treadmill Exercise ». Thesis, 2001. http://ndltd.ncl.edu.tw/handle/60808350328658158949.

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碩士
國立臺灣師範大學
體育研究所
90
During regular exercise, the determination of the energy system varies with the intensity and duration of exercise. The main source of energetic metabolism comes from carbohydrate during short duration, high intensity exercise, while during long duration exercise, the source switches gradually from carbonhydrate to fat and protein. Therefore, as far as energetic system goes, the over-consumption of bodily energy substance will lead to the inadequate supply of energy and resulting in fatigue. Fatigue is the key factor to the performance during the exercise of the runner, especially of those who participate in long duration exercise(Wilmore & Costill, 1999; Powers & Howley, 2001; Hsieh, 1997).This study is aimed at the bio-chemical influence variations on the ultramarathon and maximal treadmill exercise.Descriptive statistics will be used to analysis the results. The study selects the best male marathon runner in Taiwan as the subject of this case study. The runner is 24 years old, 164 centimeters height and weights 49 kilograms. The best record of 100-Km marathon is 7:55’57”. The study is divided into two stages. In the first stage, the runner attends a 100-Km marathon race, and his blood were sampled one day before the race and 5minutes, half an hour, 24 hours, 48 hours after the race respectively. In the other stage, the runner receives the single maximal treadmill exercise test by Bruce protocol and the blood sampling were examined in the same way as described above. The study then observes of the change of LA, glucose,HDL, LDL, TC and TG of the runner in the ultramarathon race and in the treadmill for his maximal exercise. The conclusions of the study, after a keen discussion, are as follows： I. During post-ultramarathon period, the plasma LA and TG concentrations increase; the plasma LDL and TC concentrations dwindle, while Glucose and HDL concentrations do not show significantly different. II.No great changes were found in LDL, TG and TC, whereas the concentrations of LA, glucose and HDL increase after treadmill maximal exercise. III.After ultramarathon and single maximal exercise,We found the change conditions of LA,glucose,HDL,LDL,TC and TG are different.

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JUAN, TING-FEI, et 阮庭妃. « Biochemical Evaluation of Exercise Load during Technical Training Periods in Male Collegiate Tennis Players ». Thesis, 2017. http://ndltd.ncl.edu.tw/handle/54392085921464402170.

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碩士
國立體育大學
競技與教練科學研究所
105
The intensity of training and the training load shouldn’t go beyond the limit of human body. Otherwise, athletes’ health could be jeopardized. In practice, we use creatine kinase (CK) and lactic acid (LA) in blood were used to monitor the intensity, and blood urea nitrogen (BUN) and hemoglobin (Hb) were used to monitor the loading. The purpose of this study was to evaluate the exercise load by biochemical and physiological indicators during five days technical training in tennis players. Ten male collegiate tennis players were recruited to join the training program, which was conducted by the tennis team of National Taiwan Sport University. Blood was drawn daily before and after training sessions to assess the values of LA, CK, BUN, and Hb during the experimental periods. Moreover, ratings perceived exertion (RPE) was monitored before, during and after each session, and the training load was calculated as the product of RPE and time. All data were analyzed by two-way (intra- ×inter-day) repeated-measure ANOVA. The results showed that the training load at day-1 was the lowest and was significantly lower than the value at day-4 which with the highest value (1510 ± 88 a.u. vs. 2052 ± 73 a.u., p < .05). Nevertheless, the value of BUN after training at day-1 was significantly higher than before training (23.5 ± 8.5 mg/dL vs. 17.7 ± 2.9 mg/dL, p < .05) and also significantly higher than all the other days (p < .05.). The concentration of LA immediately after training at day-1 was the highest (7.25 ± 6.38 mmol/L) and was significantly higher than all of the values in the other days (p < .05.). However, neither CK nor Hb had different between days. It is concluded that the exercise load of the five days technical training periods in male collegiate tennis players was progressive, but it was still suitable to recovery for the tennis players.

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KAN, NAI-WEN, et 甘乃文. « The Comparison of Physiological and Biochemical Responses to Various Aquatic Exercise Movements and Aquatic versus Land Exercise Modes in Postmenopausal Women ». Thesis, 2016. http://ndltd.ncl.edu.tw/handle/56860017660767809165.

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博士
國立體育大學
競技與教練科學研究所
104
The comparison of physiological and biochemical responses to various aquatic exercise movements and aquatic versus land exercise modes in postmenopausal women Due to cardiovascular protective effects decreasing with estrogen, postmenopausal women have a great morbidity rate of cardiovascular diseases. Recent studies showed that exercise could help postmenopausal women improve discomforts and reduce risk of cardiovascular diseases. Head-out aquatic-fitness exercises (AE) are popular in middle-aged and elderly women. However, it’s unclear the differences in the physiological and biochemical responses among various aquatic exercise movements and the differences in cardiovascular effects between aquatic and land exercise modes. Purposes: This study was conducted with a series of two experments consequently. (ExperimentΙ) The comparison of motion tempos and physiological responses to three aquatic movement trials involving running (RU), rocking (RO), and scissor (SC) at three intensity levels. (ExperimentⅡ) According to the results of experimentⅠ, we simulated a 30-min intermittent AE and compared physiological and cardiovascular responses in AE, land cycling (LC) and ascent treadmill (AT) modes at similar exercise prescriptions. Methods: (ExperimentⅠ) We recruited twelve sedentary postmenopausal women who conducted graded exercises to measure their maximum heart rate (HRmax) and peak oxygen uptake (VO2peak) by a bicycle ergometer and calculated their 50%, 65%, and 80% heart rate reserve (HRR) for setting low, moderate, and high exercise intensities respectively. Then each participant randomly performed three aquatic basic trials involving RU, RO, and SC step movements. Movement frequencies increased with cadences for reaching target HR, and each trail included three 6-minute steady stages upon reaching 50%, 65%, and 80% HRR individually We monitored and assayed physiological and exercise stress markers of the participants before and after every consecutive trails. Physiological markers included rate of perceived (RPE), HR, and muscle blood flow (MBF). Exercise stress markers included creatine kinase (CK), lactate, cortisol, an oxidative stress indicator and antioxidant enzyme activities. (ExperimentⅡ) The participants conducted graded exercises to measure their 50%, 65% and 80% HRR by a bicycle ergometer. Then each participant randomly performed 30-min exercise trials of aquatic exercises (AE), ascent treadmill (AT), and cycling ergometer (CE). We assayed RPE, HR, cortisol, and CK activity and monitored HR, BP, and endothelial progenitor cells (EPCs) as cardiovascular responses at different time points of each exercise mode. We used one-way ANOVA repeated measures to analyze differences in physiological and biochemical values between various exercise modes. The significance level was set to α=0.05. Results: To compare three basic movements of aquatic trials at three levels (low, moderate, and high intensities) of target HR, the motion cadences of SC trial were lower than other two trails. For reaching target HRR, RO trial was more obvious than other two trails in the phenomenon of relative exerting in upper arms and it was significant than in lower limbs. At 10-min recovery time, the responses of lactate in SC trail were higher than RO trial (p<0.05). Otherwise, there was no significant difference on recovery time and among three aqutatic exercise trails. To compare the three modes of aquatic and land exercises in the similar intensities and duration, RPE responses and lactate increasing degree in AE and CE modes were significantly higher than TE mode after exercise immediately (p<0.05). Also, BP responses in AE mode were significantly higher than TE mode. Besides, there were no significant differences among three exercise modes. Conclusions: Postmenopausal women involved in aquatic-fitness exercises may benefit from cardiorespiratory and muscle strength training and reduce their knee’s loading induced by weight-bearing. There were better exercise efficiencies included lower motion frequencies and higher lactate responses in scissor steps. To participate in 30-min intermittent exercises in similar intensities and duration, ascent treadmill exercises had moderate experience and physiological responses, but to participate in aquatic-fitness exercises we should concern about BP fluctuations in middle-aged and elderly people with pre-hypertension and hypertension. This study could be as reference for sports trainers to design programs of AE, CE and AT exercise modes in postmenopausal groups.

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Liu, Shu-Hua, et 劉淑樺. « THe Effects of Exercise Training on the Exercise Capacity, Blood Biochemical Data, Fatigue and Health Locus of Control of Hemodialysis Patients ». Thesis, 2000. http://ndltd.ncl.edu.tw/handle/30289669112362381825.

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碩士
高雄醫學大學
護理學研究所
88
The purposes of the study were to explore the effects of exercise training on the exercise capacity, blood biochemical data, fatigue and health locus of control of hemodialysis patients. 40 hemodialysis patients from a certain hospital in southern Taiwan were recruited to be the subjects according to a purposive sampling based on a quasi-experimental design. They were assigned into the experimental group and control group, 20 patients in each group. For 8 weeks, the experimental group received stationary bicycle exercise training on off-dialysis three times a week and 30-50 minutes each time while the control group did not receive any instruction related to exercise. Before receiving any training and after the 8-week exercise training, each subject was required to complete the Fatigue Scale and the Multidimensional Health Locus of Control (MHLC) Scales questionnaires. Patient’s exercise capacity and blood biochemical data were also collected. The data were analyzed by using chi-square, t-test, paired t-test and repeated measures two-way ANOVA. Results of the study showed that exercise training improved exercise capacity, reduced fasting plasma triglyceride and total cholesterol level, and decreased fatigue. However, no significant differences were found for red blood cell, hemoglobin, hematocrit, fasting plasma low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, serum glucose level and health locus of control. The findings may serve as references in the courses of renal rehabilitation. For example, the exercise training for hemodialysis patients could be incorporated with the clinical practice in order to enhance the quality of care.

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Yu-Lun, Dai, et 戴郁倫. « Effects of Coenyzme Q10 Supplementation on a single bout of exercise Induced Blood Biochemical Responses ». Thesis, 2005. http://ndltd.ncl.edu.tw/handle/84141004900333667413.

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碩士
中國文化大學
運動教練研究所
94
The purpose of this study is to investigate the effect of the hematological and biochemical data in recovery periods after a single bout of exercise with supplying Coenzyme Q10 for 3 days. Subjects are sixteen male students from Private Chinese Culture University. Every subject undertook energy metabolism systems cooperating with treadmill in order to measure the maximal oxygen uptake of every subject, and then, proceeded to a 90-minute treadmill exercise with every subject's 70% maximal oxygen uptake. Every subject implements blood test before, during, one day after, and three days after exercise, respectively. Eight subjects supplied 200 mg coenzyme Q10 right after exercise, and supplied 100 mg coenzyme Q10 every day for three days. Another eight subjects in placebo-taken group supplied 200 mg placebo right after exercise, and supplied 100 mg placebo every day for three days. Then, I proceeded these data by using one way ANOVA with α＝.05, in order to get indicators of myocardial injury in different time period of these subjects. The result of this research is as following: 1. In respect of these figures of GOT, LDH, and CK (before, during, one day after, and three days after exercise): There isn’t any obvious difference in recovery of these figures between experimental group and controlled group. 2. Troponin I: These figures of all subjects in different period are in normal range, and most of these figures are under 0.10. In conclusion, it doesn't has a obvious effect of GOT, LDH and CK.

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Huang, Yuan-Siang, et 黃園翔. « The Effects of Antrodia camphorata Mycelium Supplementation on Blood Biochemical Parameters after Exhaustive Exercise in Rats ». Thesis, 2015. http://ndltd.ncl.edu.tw/handle/87327559809700657410.

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碩士
國立新竹教育大學
體育學系碩士班
103
Abstract Purpose: The purpose of this study examined the effects of Antrodia camphorata supplementation on blood biochemical parameters after exhaustive exercise in rats. Methods: Forty male Sprague-Dawley rats were randomly divided into four groups: control (C, n = 10), exhaustive exercise (E, n = 10), A. camphorata supplemented (A, n = 10) and A. camphorata plus exhaustive exercise (AE, n = 10). A. camphorata was supplemented at the dose for four weeks. Exhaustive exercise was performed on a rodent treadmill with the progressive protocol. Two way ANOVA and t-test were performed to examine the effects of exhaustive exercise and A. camphorata supplementation on exercise duration, glucose (Glu), Lactate (Lac), lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) levels. Results: The plasma Lac, LDH, CK, MDA, and ALT levels in E group were significantly higher than C and AE group, AST activities were significantly higher than C group, while the level of Glu, SOD, GSH-Px, TG and TC were significantly lower than C group, and the plasma SOD activities were significantly lower than AE group. The level of Glu and SOD in A group was significantly higher than C group, while the level of GSH-Px levels were significantly higher than AE group, and the plasma MDA and CK levels were significantly lower than AE group. Conclusions: It was inferred from the experiment that A. camphorata mycelium supplementation could be beneficial for alleviating the fatigue after exhaustive exercise in rat, and reduce muscle damage, as well as decrease the oxidative stress and harm on liver function. It also maintains the blood glucose level, which results in prolonging the duration of endurance exercise.

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Coopoo, Yoganathan. « The effects of exercise and diet on selected physiological and biochemical parameters in a sedentary Indian male cohort ». Thesis, 1995. http://hdl.handle.net/10413/4949.

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In common with other expatriate Indian Populations, the Indian community of South Africa has a high incidence of coronary heart disease (CHD). Little information is available on the effects of exercise and diet on risk factors in this group. The present study is directed at the functional changes occurring as a result of a moderate aerobic physical activity programme, comprising 30 minutes of supervised exercise, three times per week for 15 weeks. Healthy male volunteers were recruited from the staff of the University of Durban-Westville, who were not on any lipid lowering medication and were not involved in any programme of physical activity for at least 12 weeks before the start of the project. The 41 subjects were assigned into one of three groups: exercise only (E) (15 subjects); exercise and diet (ED) (14 subjects) and a control (C) (12 subjects) group on no intervention. Besides laboratory investigations all participants were subjected to standardized fitness and anthropomorphological evaluation, a brief family history for coronary artery disease and a detailed dietary history was compiled. Baseline lipid results indicate that only 7 of the 41 subjects had normal lipid profiles using as cut-off points 5.2 mmol/l for cholesterol, 1.5 mml!l for triglyceride and 0.9 mmol/l for HDL-C. Obesity was moderately prevalent before intervention, with a mean decrease of 25% in body fat in both E and BD groups(p~0.05). The experimental subjects became leaner. After the intervention programme an average 20 percent increase was evident in physical working capacity as measured by peak V~ in both experimental groups (p~0.01). The controls showed little variation over the 15 weeks. The indices of muscular endurance and flexibility showed statistically significant changes (P~ 0.05) in both experimental groups after intervention. This certainly indicates elevated levels of fitness after the intervention. The lipid profiles show little alteration in total cholesterol, with a 7.3% decrease in triglyceride levels in the E group (which was not statistically significant) compared with a 14.7% increase in the controls. HDL-C showed an increase in both experimental groups (p~0.01). The total cholesterol to HDL-C ratio had an average fall of 11.9% in the experimental groups (P~0.05) compared with a 5.6% decrease in the control group. These data support the claim that regular, moderate exercise reduces the risk of heart disease through its effects on coronary risk factors in a high risk South African population.
Thesis (Ph.D.)-University of Durban-Westville, 1995.

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Chung, Chia-Jung, et 鍾佳蓉. « Effects of amino acid compound beverage supplementation on blood biochemical parameters during recovery phase of exhaustive exercise ». Thesis, 2009. http://ndltd.ncl.edu.tw/handle/67158876860299568866.

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碩士
國立體育大學
運動科學研究所
97
This study investigated the effects of amino acid compound beverage which includes branched-chain amino acid and arginine on acute metabolic responses during recovery of exhaustive exercise. Fourteen healthy males were assigned to drink either amino acid compound beverage (AA) or placebo (PL) in two sessions separated by 2 weeks. The heart rates were recorded before exercise and during recovery period. Blood samples of each athlete were collected before exercise, and 0, 10, 20, 40, 60, 120 minutes and 24hr after exhaustive exercise, respectively. There were no significant differences in the levels of lactate, ammonia, and CK between the two groups were observed at any of the time points. However, the concentration of glucose was significantly higher in the AA group as compared to that in the PL group at the 40 and 60-min recovery period (94.7 ± 4.5 mg/dL vs. 83.1 ± 2.8 mg/dL, 85.2 ± 4.2 vs. 75.4 ± 1.3 mg/dL, p＜.05); the insulin activity was higher in the AA group than that in the PL group at the 40 and 60-min of recovery period (31.6 ± 5.6 μlU/mL vs. 15.5 ± 2.6 μlU/mL, 30.1 ± 7.1 μlU/mL vs. 10.6 ± 1.1 μlU/ mL, p＜.05). Furthermore, the free fatty acid levels at the 60 and 120-min recovery period were significantly lower in the AA group as compared to that in the PL group (0.18 ± 0.22 mmol/L vs. 0.3 ± 0.1 mmol/L, 0.4 ± 0.1 mmol/L vs. 0.6 ± 0.1 mmol/L, p＜.05). The results indicate that consuming amino acid compound beverage during exercise recovery period could increase glucose and insulin concentration, and decrease FFA level in blood. Thus, amino acid compound beverage supplementation may benefit to energy recovery after exercise.

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Hung, En-Chung, et 洪恩忠. « Effects of chicken essence supplementation on physiological and blood biochemical parameters during exhaustive exercise and recovery period ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/25221741286175313510.

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碩士
國立臺灣體育大學(桃園)
運動科學研究所
96
The purpose of this study was to investigate the effects of chicken essence (CE) supplementation on physiological and blood biochemical parameters during exhaustive exercise and recovery period. In this randomized, double-blind, crossover study, 16 healthy males were divided into two groups (CE or placebo) and received supplementation for 14-day. After the supplement period, all the subjects performed an exhaustive exercise on the stationary bicycle ergometer at an intensity of 75 %VO2max to exhaustion. A 14-day washout period followed before the subjects crossed over and received the alternate supplement for the next 14-day. Then subjects completed the second exhaustive exercise. The heart rate, respiratory gas and exhaustion time were recorded during exercise and recovery period. Blood samples were taken prior to the exercise, at 10, 15, 20, 25 mins during exercise, immediately after exercise, and 5, 10, 15, 30, 60, 120, and 1440 mins after exercise. There were no significant differences in the concentrations of glucose, lactate, ammonia, as well as the activity of creatine kinase, heart rate, respiratory exchange ratio (RER), oxygen pulse, and exercise time to exhaustion between groups. However, the REE (resting energy expenditure) was significantly higher in CE group, as compared to that in the placebo group (1.64 ± 0.38 kcal/min vs. 1.42 ± 0.23 kcal/min, p＜.05). The results indicated that CE supplementation could not enhance exercise performance and cardiopulmonary function, but it could increase more REE in humans.

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Zhang, Min-Ty, et 張敏娣. « The effect of L-carnitine supplementation on male soccer players’ exercise performance and biochemical parameters after training ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/05208220554877675877.

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碩士
輔仁大學
營養科學系
96
L-carnitine is an ergogenic aid, which helps to transport free fatty acid into mitochondria in membrane of muscle cells, increases the metabolic rate of fatty acid, and leads to produce energy rapidly. Therefore, the aim of present study was to investigate the effect of L-carnitine supplementation on male soccer players’ exercise performance and biochemical parameters after training. A double blind, random design was used. Male soccer players would be divided into L-carnitine or placebo group. Subjects received 3200 mg L-carnitine or placebo orally per day for 3 weeks. The measurements included of body composition, exercise performance (twelve minutes run-walk test), heart rate after exercising and rating of perceived exertion after training. Besides, blood sampling of soccer players after training were analyzed for biochemical parameters, including of plasma free carnitine, total carnitine, acyl carnitine, glucose, ammonia, lactic acid, free fatty acid, serum creatine kinase, and liver and kidney biochemical markers. The results showed that exercise performance of L-carnitine group significantly increased (P<0.05), but caused no significant difference with placebo group. Body composition, heart rate after exercising and rating of perceived exertion between two groups were no significant difference on week 0 and week 3. The biochemical parameters after training showed that plasma free carnitine, acyl carnitine, total carnitine concertration of L-carnitine group were significantly higher than placebo group (P<0.05). There was no significant difference between L-carnitine group and placebo group in plasma glucose, ammonia, lactate, free fatty acid and serum creatine kinase. Serum uric acid concentration of two groups significantly decreased (P<0.05). Serum blood urea nitrogen concentration and alanine transaminase activity could significantly reduce after L-carnitine supplementation (P<0.05). Liver and kidney biochemical markers had no statistical difference between L-carnitine group and placebo group. In all, although L-carnitine supplementation can significantly increase plasma free carnitine, acyl carnitine, total carnitine concentration, but statistics demonstrates that not affecting exercise performance and other biochemical parameters after training of male soccer players, and also has no negative influence on liver and kidney function.

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胡曉瑛. « " Nutritional education combine exercise " aware of obesity schoolchildren blood biochemical measurements and nutritional knowledge to the elementary school ». Thesis, 2004. http://ndltd.ncl.edu.tw/handle/26823576247491877425.

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碩士
國立屏東科技大學
食品科學系
92
This research regard improving the poor Dietary Behaviors in schoolchildren as the purpose, hoping the Nutrition knowledge, attitude, Dietary Behaviors and blood biochemical measurements that can improve schoolchildren by the " Nutritional education combine exercise". The cardinal effect of this research is as follows: 1." Nutritional education combine exercise" can promote schoolchildren''s Nutrition knowledge effectively. 2." Nutritional education combine exercise" can promote schoolchildren''s Nutrition attitude effectively. 3." Nutritional education combine exercise" can promote schoolchildren''s Dietary Behaviors effectively. 4." Nutritional education combine exercise" can improve schoolchildren''s GOT, GPT, uric acid, triglyceride, total cholesterol, TSF and HDL effectively.

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Chang, Chia-Fang, et 張嘉芳. « A study of the Health-Related Fitness and Blood Biochemical Indexes for Patients with Metabolic Syndrome by Exercise Intervention Model ». Thesis, 2017. http://ndltd.ncl.edu.tw/handle/kfb5e9.

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碩士
國立中正大學
運動競技系運動與休閒教育研究所
105
The purpose of this study was to investigate the correlation and explanatory power between health-related fitness and blood biochemical indexes among three exercise models by Concurrent Circuit Training, Tai Chi and Aerobic Dance Training for the metabolic syndrome patients. 132 people in the community were judged as metabolic syndrome by the hospital. The subjects were randomly divided into 48 cycling group, 43 tai chi group and 41 aerobic dance group. Exercise intervention training for 12 weeks, 3 times a week, every 60 minutes. The data of fitness and blood biochemical indexes after training were analyzed by Smart PLS 2.0 statistical software. The results showed as following: 1. Tai Chi training could improve the softness, balance and agility, and then improve the coordination of energy, physical fitness model could get explanatory power of 68%. Aerobic Dance Training was a significant positive correlation between low density lipoprotein in blood biochemical indexes and 37% explanatory power of blood biochemical model. 2. The overall structure model, the concurrent circuit training program included a more comprehensive, body mass, agility, balance, softness, muscle endurance and blood glucose had been improved so that the overall model got 40% explanatory power. 3. The three intervention models of exercise had significant effective on both body fitness and blood biochemical indexes. Concurrent circuit training, Tai Chi and aerobic dance training were suitable changes from health-related fitness to blood biochemical indexes.

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Hsieh, Chang-Hua, et 謝長華. « The Effects of Regular Exercise Training on Body Composition, Cardiorespiratory Fitness, and Blood Biochemical Index in Subjects with Metabolic Syndrome ». Thesis, 2006. http://ndltd.ncl.edu.tw/handle/59773744239409238070.

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碩士
臺北醫學大學
護理學研究所
94
Abstract Title of Thesis: The Effects of Regular Exercise Training Author：Chang-Hua Hsieh Thesis directed by：Jen-Chen Tsai, Professor Many scholars’ researches have found in recent years, the metabolic syndrome is mainly caused by cardiovascular risks factor such as sedentary life style, dietary factors, genetic factors, and environment factors etc. The purpose of this study was set to evaluate effects of regular exercise training on body composition, cardiorespiration fitness, and blood biochemical index in subjects with metabolic syndrome. A quasi-experimental design was used to guide the study. Subjects in this study were metabolic syndrome with age from 18-65. They were chosen from a medical center hospital in Taipei, Taiwan. Subjects were assigned into an exercise or a control group. Complete data are available for 22 subjects in total, with 11 from exercise group and 11 from control group. The exercise group participated in a 12-weeks treadmill exercise program, three times each week, 30 minutes each time. The control group remained their living pattern. Data collected was mainly focusing on subjects’ personal data chart, blood biochemistry analysis, and exercise test. Data was analysed using percentage, mean, standard deviation, Fisher’s exact test, Mann-Whitney U test, and Wilcoxon signed ranks test. Results: (1)There is no significant difference in metabolic syndrome research results on subjects’ educational background, and smoking or drinking habits. However, male subjects’ waist to hip ratio, VO2 max , and resting diastolic blood pressure are higher than those observed in female subjects. For those subjects who have a regular job, their VO2 max are significantly higher than those who are unemployed . Subjects with better economic status also have higher VO2 max , total cholesterol, and LDL-C levels than . Subjects with family history of cardiovascular disease have fasting plasma sugar that is higher than those who have no family history. (2)After 12 weeks, two groups had significant in their resting systolic blood pressure ( p = .04). However, exercisers have improvement in their waist circumference (p = .003), waist to hip ratio (p = .02), VO2 max (p = .01), resting systolic blood pressure (p = .04), resting diastolic blood pressure (p = .02), and triglycerides (p = .03). (3)After 12 weeks, 4 exercisers (36.4%) no longer had metabolic syndrome. This study has revealed that 12-week moderate to vigorous intensity regular exercise training may help subjectsts minimizing their cardiovascular risk factors of metabolic syndrome. Key words: Metabolic Syndrome, Regular Exercise Training, Body Composition, Cardiorespiratory Fitness, Insulin Resistance.

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Chang, Hsin-Kuo, et 章新國. « The Effects of 15 Weeks Walking Exercise Intervention on Physical Fitness and Blood Biochemical Values amomg Obese Elementary School Students ». Thesis, 2012. http://ndltd.ncl.edu.tw/handle/76667334541947909552.

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碩士
亞洲大學
休閒與遊憩管理學系碩士在職專班
100
The purpose of this study is to investigate the effects of walking exercise intervention on blood biochemical values among obese elementary school students. This study is based on the Puli, Nantou County Elementary School 34 obese students of high classes. Using random groupings, divided them into 17 experimental group and 17control group. Before this experiment, the experimental group and the control group all subjects health-related fitness test and forearm vein blood test. The data for statistical analysis the paired samples t-test and independent sample t-test. The results obtained are as follows: (a) After 15 weeks walking exercise we can find the experimental group intervention on blood biochemical values and sit-ups in health physical fitness are changed. The blood biochemical values are reduced to the level of significance (p <.05); (b) This two independent samples t-test analysis results show us that the experimental group including-flexibility, muscular strength, muscular endurance, cardio-fitness and the other health physical fitness can reach the level of significance (p <.05). Otherwise their body weight, body mass index, cholesterol, triglycerides, blood glucose index are reduced to the level of significance (p <.05). Therefore, After 15 weeks walking exercise intervention will effect the fifth and sixth grade obese elementary school students on their health and fitness, promote healthy weight loss, and blood biochemical values.

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