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Littérature scientifique sur le sujet « Bioartificial blend »

Auteur : Grafiati

Publié le 14 mars 2023

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Articles de revues sur le sujet "Bioartificial blend"

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Janani, G., Samit K. Nandi, and Biman B. Mandal. "Functional hepatocyte clusters on bioactive blend silk matrices towards generating bioartificial liver constructs." Acta Biomaterialia 67 (February 2018): 167–82. http://dx.doi.org/10.1016/j.actbio.2017.11.053.

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Cristallini, Caterina, Niccoletta Barbani, Francesca Bianchi, Davide Silvestri, and Giulio D. Guerra. "BIODEGRADABLE BIOARTIFICIAL MATERIALS MADE BY CHITOSAN AND POLY(VINYL ALCOHOL). PART II: ENZYMATIC DEGRADABILITY AND DRUG-RELEASING ABILITY." Biomedical Engineering: Applications, Basis and Communications 20, no. 05 (2008): 321–28. http://dx.doi.org/10.4015/s101623720800088x.

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Bioartificial biodegradable materials were prepared mixing chitosan (CHI) and poly(vinyl alcohol) (PVA), then manufactured as films, and finally cross-linked with glutaraldehyde (GTA), both in the absence and in the presence of the edible hexa-alcohol sorbitol (SOR), as a plasticizer. The release of the components into water was tested by high performance liquid chromatography (HPLC); no release of CHI and scarce release of PVA were found. The water uptake was tested by measuring the swelling of the materials, after incubating them for 20 h in an atmosphere saturated with water vapor at 37°C. The swelling percentage increases with increasing CHI content in the blends, although it is the less hydrophilic polymer. This behavior was attributed to the difficulty of water to diffuse through the crystalline PVA structure, which is partially altered in the blends. The addition of SOR enhances the water sorption, as expected. The biodegradability of the materials was tested using the specific enzyme chitosanase, and was found to depend on the blend composition, as well as to be enhanced by the addition of SOR. The initial degradation rates were calculated; the maximum rates were found when the CHI to PVA ratio was 80:20 for all systems. The results of the enzymatic degradation generally agree with those of the swelling. The cross-linked blends were also tested as drug-delivery systems. The drugs chosen were the vitamin L-ascorbic acid (AsA) and the anti-cancer drug paclitaxel (PTX). The effective diffusion coefficients, D eff , were evaluated for the release of both the drugs from each material. Those of AsA are greater, of many powers of ten, than those of PTX, owing mainly to the hydrophilic nature of the first drug and to the hydrophobic of the second one. In conclusion, these materials seem available for biomedical use.

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Caddeo, Silvia, Monica Mattioli-Belmonte, Claudio Cassino, et al. "Newly-designed collagen/polyurethane bioartificial blend as coating on bioactive glass-ceramics for bone tissue engineering applications." Materials Science and Engineering: C 96 (March 2019): 218–33. http://dx.doi.org/10.1016/j.msec.2018.11.012.

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Bernal-Ballen, Andres, Jorge-Andres Lopez-Garcia, and Kadir Ozaltin. "(PVA/Chitosan/Fucoidan)-Ampicillin: A Bioartificial Polymeric Material with Combined Properties in Cell Regeneration and Potential Antibacterial Features." Polymers 11, no. 8 (2019): 1325. http://dx.doi.org/10.3390/polym11081325.

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Chitosan, fucoidan, and polyvinyl alcohol are categorized as polymers with biomedical applications. Ampicillin, on the other hand, is considered as an important antibiotic that has shown effectivity in both gram-positive and gram-negative micro-organisms. The aforementioned polymers possess unique properties that are considered desirable for cell regeneration although they exhibit drawbacks that can affect their final application. Therefore, films of these biomaterials were prepared and they were characterized using FTIR, SEM, XRD, degree of swelling and solubility, and MTT assay. The statistical significance of the experiments was determined using a two-way analysis of variance (ANOVA) with p < 0.05. The characterization techniques demonstrated that the obtained material exhibits properties suitable for cell regeneration, and that a higher concentration of natural polymers promotes cells proliferation to a greater extent. The presence of PVA, on the other hand, is responsible for matrix stability and dictates the degree of swelling and solubility. The SEM images demonstrated that neither aggregations nor clusters were formed, which is favorable for the biological properties without detrimental to the morphological and physical features. Cell viability was comparatively similar in samples with and without antibiotic, and the physical and biological properties were not negatively affected. Indeed, the inherent bactericidal effect of chitosan was reinforced by the presence of ampicillin. The new material is an outstanding candidate for cell regeneration as a consequence of the synergic effect that each component provides to the blend.

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Barbani, Niccoletta, Caterina Cristallini, Mariacristina Gagliardi, Giulio D. Guerra, and Davide Silvestri. "Bioartificial chitosan-poly(vinyl alcohol) blends as biomaterials." Biomedicine & Pharmacotherapy 62, no. 8 (2008): 487. http://dx.doi.org/10.1016/j.biopha.2008.07.002.

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Barbani, Niccoletta, Luigi Lazzeri, Caterina Cristallini, Maria Grazia Cascone, Giovanni Polacco, and Giovanna Pizzirani. "Bioartificial materials based on blends of collagen and poly(acrylic acid)." Journal of Applied Polymer Science 72, no. 7 (1999): 971–76. http://dx.doi.org/10.1002/(sici)1097-4628(19990516)72:7<971::aid-app13>3.0.co;2-n.

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Soldani, G., and R. Mercogliano. "Bioartificial Polymeric Materials Obtained from Blends of Synthetic Polymers with Fibrin and Collagen." International Journal of Artificial Organs 14, no. 5 (1991): 295–303. http://dx.doi.org/10.1177/039139889101400510.

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Calandrelli, Luigi, Anna Calarco, Paola Laurienzo, Mario Malinconico, Orsolina Petillo, and Gianfranco Peluso. "Compatibilized Polymer Blends Based on PDLLA and PCL for Application in Bioartificial Liver." Biomacromolecules 9, no. 6 (2008): 1527–34. http://dx.doi.org/10.1021/bm7013087.

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Silvestri, Davide, Niccoletta Barbani, Giulio D. Guerra, Mariacristina Gagliardi, and Caterina Cristallini. "BIODEGRADABLE BIOARTIFICIAL MATERIALS MADE BY CHITOSAN AND POLY(VINYL ALCOHOL) PART III: MATERIALS TOUGHENED BY MEANS OF A DEHYDROTHERMAL TREATMENT." Biomedical Engineering: Applications, Basis and Communications 22, no. 06 (2010): 509–17. http://dx.doi.org/10.4015/s1016237210002250.

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The bioartificial chitosan–poly(vinyl alcohol) blends were toughened by means of a dehydrothermal treatment (DHT), to facilitate the formation of hydrogen bonds between the macromolecules. The materials were characterized by stress–strain test, contact angle measurement, spotlight Fourier transform infrared spectroscopy and chemical imaging, weight loss in water, swelling in water vapor saturated atmosphere, Alamar blue test to evaluate the indirect cytotoxicity, and the diffusive permeation, through membranes made with the blends, of D(+)glucose, vitamin B12, and bovine serum albumin. The results were compared with those of the blends crosslinked by glutaraldehyde (GTA). The Young's modulus ranges between 10.56 and 16.12 MPa, and it is higher for the blends subjected to DHT than for those crosslinked by GTA, a fact explainable by the elasticity of the latter, due to the flexible bridges connecting the different chains. The contact angles indicate a scarce wettability, and then a scarce hydrophilicity, which is confirmed by the chemical imaging of the surfaces, made in the total reflection (microATR) mode, of the films toughened by DHT: the ν(OH) band in the 4000–3000 cm-1 is nearly absent in all the regions of the maps. Moreover, the correlation maps indicate a homogeneous distribution of the two components within the blends. The weight loss in water is generally less than 15%, and increases with the content of the ionizable macromolecule chitosan in the blends, a trend shown also by the swelling after exposure to water vapors. Alamar blue test shows that none of the eluates, after being in contact with the materials up to seven days, appears cytotoxic toward murine fibroblasts. As concerning the diffusive permeation, it appears good for D(+)glucose, quite good for vitamin B12, and scarce for bovine serum albumin. In conclusion, the chitosan–poly(vinyl alcohol) blends studied appear to be suitable for their use as biomaterials.

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Lungu, M., M. C. Pascu, G. G. Bumbu, H. Darie, C. Vasile, and L. Moldovan. "BIOARTIFICIAL POLYMER MATERIALS BASED ON PVC/NATURAL POLYMER BLENDS: BINARY PVC/HYDROLYZED COLLAGEN BLENDSv." International Journal of Polymeric Materials 53, no. 6 (2004): 525–40. http://dx.doi.org/10.1080/00914030490267636.

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Chapitres de livres sur le sujet "Bioartificial blend"

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Giusti, Paolo, Niccoletta Barbani, Luigi Lazzeri, Giovanni Polacco, Caterina Cristallini, and Maria G. Cascone. "Gelatin-Poly(Vinyl Alcohol) Blends as Bioartificial Polymeric Materials." In Science and Technology of Polymers and Advanced Materials. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0112-5_39.

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Actes de conférences sur le sujet "Bioartificial blend"

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Ionita, Mariana, Davide Silvestri, Alfonso Gautieri, Emiliano Votta, Gianluca Ciardelli, and Alberto Redaelli. "Molecular Modelling of Small Molecule Diffusion in Biopolymer Blends Membranes for Biomedical Applications." In ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95671.

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In order to improve the biological performance of synthetic polymers and to enhance the mechanical characteristics by tailoring the permeability properties of biopolymers, a new class of specifically designed materials (bioartificial polymeric materials), consisting of blends of synthetic polymers and biopolymers, has been recently introduced. In this work we present a computational method based on molecular mechanics (MM) and dynamics (MD) techniques, to investigate their permeability to small molecules. The permeability properties was assessed of poly(vinyl alcohol)-(PVA)- dextran-(Dex) and poly(acrylic acid)-(PAA)-Dex membranes with different blend composition. Amorphous bulk models of PVA–Dex and PAA–Dex mixtures with 80:20, 60:40, 40:60 (w/w) ratios were generated. Two steps have been performed iteratively, the former using a MM simulation for equilibration and the latter using MD simulations for model refinement. Virtual uniaxial traction tests were performed, adopting the Second Derivative (SD) procedure, in order to assess the mechanical behavior of the bulk models. The diffusion coefficients for H2O were determined via NVT molecular dynamics simulations. Using the data of the motion of water inside the bulk models, the diffusivity constant was calculated applying the Einstein equation. Correlation of diffusion coefficients with free volume, was found. The results of the simulations agree with theoretical considerations: as the content of dextran increases from 80:20 to 40:60 a 86 % decrease of the diffusion constant is obtained and the values (range 0.14–56.5 10−6 cm2s−1) have the order of magnitude expected, and similar on the diffusion of small molecules in amorphous polymeric membranes.

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