Thèses sur le sujet « Bioactive Synthesis »
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Zheng, Zehua. « Synthesis of bioactive natural products ». Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59815.
Texte intégralScience, Faculty of
Chemistry, Department of
Graduate
Nelson, A. « Synthesis of bioactive indolizidine alkaloids ». Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421009.
Texte intégralShan, Yulong. « Bioactive carbohydrates : isolation, synthesis and conjugation ». Thesis, Bangor University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556079.
Texte intégralCarbain, Benoît. « A convenient synthesis of bioactive cyclohexenephosphonates ». Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/2367/.
Texte intégralUsai, Igor. « Synthesis of novel bioactive doxycycline derivatives ». kostenfrei, 2008. http://www.opus.ub.uni-erlangen.de/opus/volltexte/2008/1082/.
Texte intégralHu, Yaogang. « Design and Synthesis of Bioactive Peptidomimetics ». Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5504.
Texte intégralTyrrell, Andrew J. « Approaches to the synthesis of bioactive pyrrolizidines ». Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497131.
Texte intégralMiranda, Vanessa. « Synthesis of new bioactive autoinducer-2 analogues ». Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/94059.
Texte intégralN/A
Isoni, Valerio. « Asymmetric synthesis of bioactive alkaloids from Amaryllidaceae ». Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/355712/.
Texte intégralSoldati, Roberto <1986>. « Synthesis of new bioactive β-lactam compounds ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6974/1/Soldati_Roberto_Tesi.pdf.
Texte intégralSoldati, Roberto <1986>. « Synthesis of new bioactive β-lactam compounds ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6974/.
Texte intégralStevens, Kiri. « Methodology for the synthesis of NP25302 and other bioactive natural products ». Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:ae18879e-d75e-4280-ba55-1ae08e64034f.
Texte intégralLear, Sam. « Total synthesis of bioactive peptides and whole proteins ». Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11946/.
Texte intégralChlubnová, Ilona. « Chemo-enzymatic synthesis of bioactive furanosyl-containing glycoconjugates ». Rennes 1, 2010. http://www.theses.fr/2010REN1S196.
Texte intégralLes hexofuranoses sont absents chez les mammifères, mais sont présents dans de nombreux micro-organismes souvent hautement pathogènes, ce qui les rend très intéressants pour le développement de nouveaux médicaments antimicrobiens. Les enzymes sont de plus en plus souvent utilisées pour la synthèse de glycoconjugués comme une alternative à la synthèse organique. Dans ce travail, nous présentons l'utilisation d’alpha-l-Arabinofuranosidase Araf51 pour la synthèse de glycoconjugés contenant des unités furanosidiques. Cette enzyme s’est révélée très efficace pour catalyser les oligomérisations des dérivés du l-arabinofuranoside et ceux du d-galactofuranoside jusqu'à la formation de pentasaccharides, ainsi que dans la synthèse de furanosides contenant des motifs structuralement modifiés du d-galactofuranose et des disaccharides de type pyrano-furano. Un grand nombre de composés synthétisés présentent des structures d’intérêt biologique que l’on retrouve dans certains agents pathogènes. Les essais biologiques ont montré que ces néofuranosides ont de fortes propriétés immunostimulatrices et peuvent potentiellement constituer un nouveau type d’adjuvants
Eaton, Alexander Lee. « Isolation and Synthesis of Bioactive Compounds from Plants ». Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64367.
Texte intégralPh. D.
Chyan, Ming-Kuan. « Synthesis and Study of Bioactive Compounds : I. Pyrethroids ; II. Glutathione Derivatives ». Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278848/.
Texte intégralLahore, S. « ¿SYNTHETIC STUDIES TOWARDS BIOACTIVE FUNGAL METABOLITES¿ ». Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229905.
Texte intégralSemak, Vladislav. « Synthesis of 1S-ethyl-4-substituted quinolizidines and other potentially bioactive compounds ». Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97241.
Texte intégralA dissertation submitted by Vladislav SEMAK to obtain a doctoral degree from University of Barcelona. This thesis was developed under the supervision of Dr. Carmen Escolano Mirón from Faculty of Pharmacy, University of Barcelona. This doctoral thesis is presented as a compendium of publications. The thesis is divided in four chapters: CHAPTER 1 – PART A: Enantioselective, Protecting Group-Free Synthesis of 1S-Ethyl-4-Substituted Quinolizidines (Amat, M.; Semak, V.; Escolano, C.; Molins, E.; Bosch, J. Org. Biomol. Chem. 2012, 10, 6866-6875.) A practical enantioselective protecting group-free four-step route to the key quinolizidinone 6 from phenylglycinol-derived bicyclic lactam 1 is reported. The organometallic addition reaction upon 6 takes place stereoselectively to give 1-ethyl-4-substituted quinolizidines 4-epi-207I and 7-9. Following a similar synthetic sequence, 9a-epi-6 is also accessed. However, the addition of Grignard reagents upon 9a-epi-6 proceeds in a non-stereoselective manner. In order to gain insight into the different stereochemical outcome in the two series, theoretical calculations on the iminium salts A and B have been performed. The study concludes that the addition of the hydride, which is the step that determines the configuration of the final products, occurs in a stereoelectronic controlled manner. CHAPTER 1 – PART B: A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams (V. Semak; C, Escolano; C. Arróniz; J. Bosch; M. Amat Tetrahedron: Asymmetry 2010, 21, 2542-2549.) Chiral non-racemic bicyclic lactams derived from phenylglycinol have been appointed as key building blocks for the preparation of enantiopure nitrogen compounds. The removal of the chiral inductor leading to substituted piperidones by using air or oxygen in basic media is presented in this chapter. CHAPTER 2: Synthesis of triheptanoin and formulation as a solid diet for rodents (Semak, V.; Semakova, J.; Halbaut, L.; Asó, E.; Ferrer, I.; Calpena, A.; Escolano, C.; Perales, J. C. Eur. J. Lipid Sci. Technol. 2012, 114, 889-895.) In the present study, we successfully synthesized triheptanoin to the highest standards of purity from glycerol and heptanoic acid, using sulfonated charcoal as a catalyst. Triheptanoin oil was then formulated as a solid, stable and palatable preparation using a ketogenic base and a combination of four commercially available formulation agents: hydrophilic fumed silica, hydrophobic fumed silica, microcrystalline cellulose, and talc. Diet compliance and safety was tested on C57Bl/6 mice over a 15-week period, comparing overall status and body weight change. CHAPTER 3: Toluene dioxygenase mediated oxidation of halogen-substituted benzoate esters (Semak, V.; Metcalf, T. A.; Endoma-Arias, M. A. A.; Mach, P.; Hudlicky, T. Org. Biomol. Chem. 2012, 10, 4407-4416.) A series of ortho-, meta-, and para-halogen-substituted methyl benzoate esters was subjected to enzymatic dihydroxylation via the whole-cell fermentation with E. coli JM109 (pDTG601A). Only ortho-substituted benzoates were metabolized. Methyl 2-fluorobenzoate yielded one diol regioselectively whereas methyl 2-chloro-, methyl 2-bromo- and methyl 2-iodobenzoates each yielded a mixture of regioisomers. Absolute stereochemistry was determined for all new metabolites. Computational analysis of these results and a possible rationale for the regioselectivity of the enzymatic dihydroxylation is advanced. CHAPTER 4: Dauben–Michno oxidative transposition of allylic cyanohydrins. Enantiomeric switch of (–)-carvone to (+)-carvone. (Hudlicky, J. R.; Werner, L.; Semak, V.; Simionescu, R.; Hudlicky, T. Can. J. Chem. 2011, 89, 535-543.) Allylic cyanohydrins were subjected to Dauben–Michno oxidation at low temperatures to provide β-cyanoenones in good to excellent yields. The potential of this oxidative transposition as a means of an enantiomeric switch of enones containing a latent plane of symmetry was tested by conversion of (–)-carvone to its enantiomer.
Saito, Yu. « Synthesis of bioactive compounds : Synthetic study of D-Lac-terminated peptidoglycan fragment structures ». Thesis, KTH, Kemiteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300085.
Texte intégralPeptidoglycan (PGN) is a bacterial cell wall component and known to be recognized by various receptors or enzymes to lead the activation immune system. The general structure of PGN consists of sugar chains including N-acetylglutamine (GlcNAc), N-acetylmuramic acid (MurNAc) and cross-linked peptide chains. PGN fragments having D-Lac terminus peptides have been found from vancomycin-resistant enterococcus, but a chemically synthesized PGN fragment having a D-Lac terminus peptide has not been examined in detail. Thus, we focused on the synthesis of PGN fragment structures that include a D-Ala-D-Lac residue at the terminal part of the peptide chain. In order to synthesize these fragment structures, we planned to combine solid-phase synthesis (for the peptide- Lac part) and solution-phase synthesis (for glycan preparation and the condensation). This approach is advantageous for the preparation of peptidoglycan fragments having complex branched peptide moiety. First, we prepared the sugar moiety MurNAc derivative in solution-phase synthesis from a glucose derivative. While, the Lac-containing peptide was prepared with solid-phase peptide synthesis using 2-chlorotrityl chloride resin. Having this compound, the condensation of these two compounds gave the desired D-Lac-terminated peptidoglycan fragment.
Pereira, Alban R. « Marine natural products : synthesis and isolation of bioactive analogues ». Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/7526.
Texte intégralHunter, Darren F. A. « Synthesis of bioactive pyrrolidine and piperidinone derivatives from carbohydrates ». Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418528.
Texte intégralWeston, Matthew. « Towards the asymmetric total synthesis of bioactive Celastraceae sesquiterpenoids ». Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274986.
Texte intégralGill, Iqbal Singh. « Enzymatic synthesis of short bioactive peptides in novel media ». Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335913.
Texte intégralZerla, D. S. « Synthesis of chiral bioactive molecules by Catalytic Asymmetric Reduction ». Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/147565.
Texte intégralStraniero, V. « DESIGN AND SYNTHESIS OF NOVEL BIOACTIVE PEPTIDES AND PEPTIDOMIMETICS ». Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217536.
Texte intégralStucchi, M. « MULTICOMPONENT APPROACHES TO THE SYNTHESIS OF SMALL BIOACTIVE MOLECULES ». Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330951.
Texte intégralSecci, Francesco. « Strained carbocyclic systems in the synthesis of bioactive products : methodologies and total synthesis ». Paris 11, 2006. http://www.theses.fr/2006PA112296.
Texte intégralTang, Shoubin. « Structural and Synthetic Studies of Bioactive Natural Products ». Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26104.
Texte intégralPh. D.
Tran, Wendy. « Synthesis of Bioactive Natural Products & ; Derivatives as Novel Anti-infectives ». Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23995.
Texte intégralTrippier, Paul Charles. « Synthesis of highly substituted heterocycles : the oxazolomycins ». Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:b758987c-7a0c-4c1b-982c-61b4d383680a.
Texte intégralKhanizeman, Rabi'ah Nisha. « Studies towards the synthesis of bioactive natural products and development of new synthetic methods ». Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066644.
Texte intégralIt has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. This, thus, indicates that natural products (NP), together with natural product derived and natural product inspired structures are significant as sources for potential leads towards the discovery of new drugs. The introduction of this thesis thereby highlights the importance of natural products in the field of drug discovery. In addition, the introduction emphasizes on the importance of natural products as a field of research. This is as the synthesis of natural products can result in the development of new synthetic methods which can then be applied to a broader range of applications across the field of chemistry. This new information, thus, bridges a gap in the scientific knowledge and allows for progress in science. Therefore the content of this thesis describes the syntheses and development of new synthetic methods towards bioactive natural products containing 1,3-amino alcohol, 1.3-diamine, THP-ring as well as tri-aryl ethylene unit which represent the key themes of (+)-negamycin (Chapter 1), (-)-cernuine and (+)-cermizine D (Chapter 2), enigmazole A (Chapter 3) and tamoxifen (Chapter 4), respectively
Kilburn, John Paul. « Novel solid-phase synthesis strategies for the preparation of heterocycles and guanidines ». Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247056.
Texte intégralLi, Sifeng. « Hydrofunctionalization of alkenes and their applications in the synthesis of bioactive compounds ». HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/812.
Texte intégralXynos, Ioannis D. « Bioactive glasses for the in vitro synthesis of bone tissue ». Thesis, Imperial College London, 2001. http://hdl.handle.net/10044/1/11494.
Texte intégralYan, Luping. « Bioactive marine natural products : analogue synthesis, SAR, and target identification ». Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50069.
Texte intégralScience, Faculty of
Chemistry, Department of
Graduate
Blanc, Antoine. « Synthesis on the solid phase of a bioactive tryptathionine octreotate ». Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61821.
Texte intégralForestieri, Roberto. « Isolation, structure elucidation, and total synthesis of bioactive natural products ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45668.
Texte intégralShabbir, Ghulam. « The synthesis and mechanism of formation of some bioactive heterocycles ». Thesis, University of Hertfordshire, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365934.
Texte intégralAlmaliti, Jehad S. « Natural Products-Inspired Synthesis and Biological Evaluation of Bioactive Agents ». University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384555204.
Texte intégralAntonopoulou, Io. « Use of feruloyl esterases for chemoenzymatic synthesis of bioactive compounds ». Licentiate thesis, Luleå tekniska universitet, Kemiteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-62836.
Texte intégralAMABILI, PAOLO. « α-Hydrazido acids for the synthesis of bioactive amphiphilic compounds ». Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245568.
Texte intégralNovel mimics of β-peptides based on the formal substitution Cβ→Nβ(acyl) were synthesized with the aim to obtain new foldamers (oligomers with a predictable folding). Thus, we modified pirrolidin-2-one tethered β-amino acids, previously used in our laboratory to prepare hexamers, devised a new imidazolidinone-tethered α-hydrazido acid (AOPIC) suitable to give oligomers that were analysed using spectroscopic (NMR and CD) and computational (MD) techniques. The computational analysis, besides furnishing the theoretical proof of the 8-helix as the only stable structure, strongly evidenced a “hydrazido-turn” sequence, where additional 5-membered H-bonded cycles were enclosed within the 8-membered ones. In the search for simpler and cheaper analogues, we directed our attention towards analogues of the previously employed oligomers, where constrictions and chirality were missing, with the aim to obtain a secondary structure with minor synthetic effort and increased versatility in side chains substitution. In fact, an appropriate disposition of side chains could be a good starting point for the synthesis of amphiphilic foldamers to be tested as antibacterial agents. Since many difficulties are connected with the use of peptide drugs, synthetic mimics of AMPs (SMAMPs) are receiving ever more interest and importance as new drug candidates, owing to the rapid and widespread development of antibiotic resistances. Thus, within this topic, we carried out the synthesis of amphiphilic α-hydrazido acid derivatives, which could be novel lead compounds for developing a new class of SMMAMPs. The Minimum Inhibitory Concentration (MIC) was evaluated for a few properly derivatized α-hydrazido acid monomers, and the preliminary results showed a promising antimicrobial activity suitable for biological applications, eventually leading to a structure optimization for improvement of the pharmacological properties.
Tinarelli, Alessandro <1975>. « Novel Methodologies for the Synthesis of Scaffolds for Bioactive Molecules ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2291/1/Tinarelli-Alessandro-tesi.pdf.
Texte intégralTinarelli, Alessandro <1975>. « Novel Methodologies for the Synthesis of Scaffolds for Bioactive Molecules ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2291/.
Texte intégralZang, Qin. « Towards the total synthesis of peloruside A analogues ». Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1663059931&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Texte intégralStout, Elizabeth Paige. « Discovery and synthesis of bioactive natural product probes from marine systems ». Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37301.
Texte intégralChen, Xiaoyun [Verfasser]. « The synthesis of bioactive sulfoximines and N-alkynylated sulfoximines / Xiaoyun Chen ». Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1066984204/34.
Texte intégralDerudas, Marco. « Design, synthesis and biological evaluation of novel bioactive nucleosides and nucleotides ». Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55855/.
Texte intégralMontgomery, Laura Jane. « Investigations of the biosynthesis and biomimetic synthesis of bioactive natural products ». Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/4420/.
Texte intégralFilipa, P. da Cruz Ana. « C-branched carbohydrate lactones : Versatile intermediatesin the synthesis of branched bioactive ». Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509913.
Texte intégralFara, Mario Antonio. « Cell penetrating peptoid carriers : microwave assisted synthesis and bioactive molecules delivery ». Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/10889.
Texte intégral