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Sehgal, Jyoti, et Manoj Kumar. « 12-Bit Clock Gated SAR-ADC for Bio-Medical Applications ». Indian Journal Of Science And Technology 15, no 34 (13 septembre 2022) : 1648–54. http://dx.doi.org/10.17485/ijst/v15i34.1033.
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KIGUCHI, Kazuo, Hiroshi SATO et Junichi KARIYA. « BIO-12 SENSORY FEEDBACK OF AN INTELLIGENT ARTIFICIAL ARM(Bio-medical Equipments III,Technical Program of Oral Presentations) ». Proceedings of JSME-IIP/ASME-ISPS Joint Conference on Micromechatronics for Information and Precision Equipment : IIP/ISPS joint MIPE 2009 (2009) : 319–20. http://dx.doi.org/10.1299/jsmemipe.2009.319.
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Munarwan, Edi. « KARAKTERISTIK BIO-OIL HASIL PIROLISIS LIMBAH BREM DENGAN VARIASI TEMPERATUR ». JTT (Jurnal Teknologi Terpadu) 7, no 1 (21 mai 2019) : 23–28. http://dx.doi.org/10.32487/jtt.v7i1.552.
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Abstract The increasing number of automotive technology and vehicle cause using fossil fuel also rises. So it is needed alternative fuel as replacement or mixing of the fuel, for keeping the existence so that the crisis of fuel will not happen. Bio-oil is a product resulted from pyrolisis which can be used as solar fuel mixing. Bio-oil is a obtained from brem waste which is processed with pyrolisis technique. Pyrolisis is a substance burning process in high temperature without using oxygen. In this research is using 250oC, 350oC, 450oC and 550oC temperature variation which need 3 hours of time and mass 500 grams. The Bio-oil which is produced by pyrolisis is combined by solar and tested to determine the characteristic. The first trial is done to earn the volume pyrolisis result from each temperature. The second trial uses ASTM D 445-12 method to earn viscosity in 40oC temperature and ASTM D 93-12 method to get flash point. The result of the trial shows the highest volume is earned from 5500C temperature which produce bio-oil around 254 ml. The trial result of 5% bio-oil combination from every temperature is earned the best result from 450oC temperature, while the optimal mixing percentage bio-oil with solar is earned the highest viscosity inmixture of 15% bio-oil which 85% solar around 4,779 mm2/s and the highest flash point is earned from mixture of 5% bio-oil which 95% solar around 61oC. Keywords : bio-oil, pyrolysis, flash point, viscosity AbstrakPeningkatan teknologi otomotif dan jumlah kendaraan yang meningkat menyebabkan penggunaan bahan bakar fosil semakin meningkat. Maka dibutuhkan bakan bakar alternatif sebagai pengganti atau campuran bahan bakar, untuk menjaga agar tidak terjadi krisis bahan bakar. Bio-oil merupakan salah satu produk hasil pirolisis yang dapat digunakan sebagai campuran bahan bakar solar. Bio-oil diperoleh dari limbah brem yang diproses dengan cara pirolisis. Pirolisis merupakan proses pembakaran suatu bahan pada suhu tinggi tanpa oksigen. Pada penelitian ini menggunakan variasi temperatur 250oC, 350oC, 450oC dan 550oC dengan waktu 3 jam dan massa 500 gram. Bio-oil hasil pirolisis divariasikan dengan solar dan diuji untuk mengetahui karakteristiknya. Pengujian pertama dilakukan untuk mendapatkan volume hasil pirolisis dari tiap temperatur. Pengujian kedua menggunakan metode ASTM D 445-12 untuk mendapatkan viskositas pada suhu 40oC dan metode ASTM D 93-12 untuk mendapatkan titik nyala. Hasil pengujian menunjukkan volume tertinggi diperoleh dari temperatur 5500C menghasilkan bio-oil sebanyak 254 ml. Hasil pengujian variasi campuran 5% bio-oil dari tiap temperatur diperoleh hasil yang terbaik yaitu dari temperatur 4500C, sedangkan persentase campuran yang optimal bio-oil dengan solar diperoleh viskositas tertinggi pada campuran 15% bio-oil dengan 85% solar sebesar 4,779 mm2/s dan titik nyala tertinggi diperoleh dari campuran 5% bio-oil dengan 95% solar sebesar 61oC Kata Kunci: : bio-oil, pirolisis, titik nyala, viskositas
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Lim, Shin-Il, Jin Woo Kim, Kwang-Sub Yoon et Sangmin Lee. « A 12-b Asynchronous SAR Type ADC for Bio Signal Detection ». JSTS:Journal of Semiconductor Technology and Science 13, no 2 (30 avril 2013) : 108–13. http://dx.doi.org/10.5573/jsts.2013.13.2.108.
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Fibria, Milda, Catur Yuliani R et Tri Purnami. « Pembuatan Gemuk Lumas Bio Menggunakan Thickener Berbasis 12-Hsa Produksi Lokal ». Lembaran publikasi minyak dan gas bumi 50, no 1 (24 avril 2016) : 21–27. http://dx.doi.org/10.29017/lpmgb.50.1.727.
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Gemuk lumas merupakan kombinasi minyak lumas dan bahan pengental (thickener). Thickener memberikan karakteristik kekakuan terhadap gemuk lumas yang merupakan ukuran resistensi terhadap deformasi oleh gaya yang diberikan. Thickener dibuat dengan mereaksikan asam 12-Hidroksistearat (HSA) dan litium hidroksida untuk menghasilkan gemuk lumas yang memiliki resistensi yang tinggi terhadap air. Kebutuhan terhadap asam 12-hidroksistearat (HSA) sebagai bahan thickener gemuk lumas cukup signifi kan. Namun produk ini belum diproduksi di Indonesia, sehingga industri gemuk lumas masih mengandalkan produk impor. Padahal bahan baku yang digunakan yaitu minyak jarak, justru banyak diproduksi di dalam negeri. Sehingga dibuatlah asam 12-hidroksistearat dari minyak jarak yang diproduksi di laboratorium pelumas PPPTMGB Lemigas. Hal ini imaksudkan untuk mengurangi impor 12-HSA, menggantinya dengan produk lokal. Berdasarkan hasil penelitian mengenai pembuatan gemuk lumas bio menggunakan thickener (lokal) berbasis minyak jarak, dapat disimpulkan bahwa, formulasi gemuk lumas bio menggunakan thickener berbasis minyak jarak produk lokal memiliki performa yang setara dengan produk impor. Bahkan apabila dilakukan treatment dengan baik maka akan dapat menghasilkan gemuk lumas yang lebih unggul dibanding penggunaan thickener dengan bahan baku impor. Pemanfaatan minyak jarak dalam penelitian menghasilkan peningkatan TKDN produk mencapai 95%.
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Venkat, R. Batta, P. Keall, A. Sawant et R. George. « SU-FF-J-12 : Respiratory Training Using Audio Visual Bio-Feedback ». Medical Physics 34, no 6Part5 (juin 2007) : 2370. http://dx.doi.org/10.1118/1.2760517.
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Taya, Minoru, T. Wada et M. Kusaka. « W05-(12) Bio-inspired Design of Materials for Actuators and Sensors ». Reference Collection of Annual Meeting VIII.03.1 (2003) : 300–301. http://dx.doi.org/10.1299/jsmemecjsm.viii.03.1.0_300.
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Zuijderhoudt, F. M. J., et J. Dorresteijn-de Bok. « Comparison of the Bio-Rad Porphyrin Column Test with a Simple Spectrophotometric Test for Total Urine Porphyrin Concentration ». Annals of Clinical Biochemistry : International Journal of Laboratory Medicine 35, no 3 (mai 1998) : 418–21. http://dx.doi.org/10.1177/000456329803500312.
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We compared two screening methods for increased urine porphyrin concentration and compared the results with a high-performance liquid chromatography (HPLC) method. The screening methods were the Bio-Rad (Porphyrin) Column Test and a simple spectrophotometric method. Results were obtained for urines with three different porphyrin patterns. Both screening methods were easy to perform. The accuracy and precision of the spectrophotometric method were both slightly better than that of the Bio-Rad Column Test. Recovery measurements in samples with different porphyrin patterns varied between 73% and 59% ( n = 12) for the spectrophotometric method and between 82% and 116% ( n = 12) for the Bio-Rad Column Test as compared to HPLC. Between batch precision measurements revealed coefficients of variation for spectrophotometric and Bio-Rad methods for 2%–4% and 4%–10%, respectively. The recovery of the porphyrins illustrates the Bio-Rad Column Test to be more susceptible to variation in urine porphyrin composition. Both methods will show satisfactory results in cases of overt porphyria because of the high urine porphyrin concentration.
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Jiwantoro, Yudha Anggit, Rabi’unnisa Sulaimah, Arief Taufikurrahman, Wa’dah Salsabila, Zurriatun Toyyibah et Maruni Wiwin Diarti. « Bio-Porter Sebagai Spesimen Container Transport Alternatif Berbasis Thermoelectric Cooler System ». Bioeduca : Journal of Biology Education 3, no 2 (30 septembre 2021) : 82–90. http://dx.doi.org/10.21580/bioeduca.v3i2.6607.
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Keakuratan hasil laboratorium dipengaruhi oleh stabilitas spesimen selama proses pengiriman. Penelitian ini bertujuan untuk membuat inovasi berupa spesimen container transport berbasis thermoelectric cooler system yang diberi nama Bio-Porter dalam mempertahankan stabilitas spesimen klinis. Jenis penelitian ini adalah Pra Experimental dengan rancangan penelitian berupa One Group Pretest-Posttest Design. Sampel pada penelitian adalah spesimen darah yang diambil dengan teknik accidental sampling pada mahasiswa berjumlah 5 orang yang diberi perlakuan yakni penyimpanan spesimen darah dalam Bio-Porter pada suhu 6℃ selama 12 jam dan 24 jam lalu diukur kadar kolesterol total dan glukosa darah. Berdasarkan hasil uji statistik Oneway Anova diperoleh nilai sig. sebesar 0,857 yang berarti tidak terdapat perbedaan yang bermakna terhadap stabilitas spesimen pada spesimen darah sebelum dan setelah disimpan dalam Bio-Porter suhu 6℃ selama 12 jam dan 24 jam. Sehingga Bio-Porter sebagai specimen container transport berbasis thermoelectric cooler system dapat mempertahankan stabilitas spesimen.
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Redžovoić, Jasmina, Ćazim Crnkić, Muhamed Smajlović et Dinaida Tahirović. « Utjecaj termičke obrade na sadržaj željeza, cinka, bakra i magnezija u mesu junadi iz intenzivnog i ekstenzivnog tova ». Meso 24, no 4 (14 juillet 2022) : 336–46. http://dx.doi.org/10.31727/m.24.4.4.
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Cilj ovog rada bio je ispitati utjecaj termičke obrade kuhanjem na sadržaj željeza (Fe), cinka (Zn), bakra (Cu) i magnezija (Mg) u mišićnom tkivu i jetri junadi u ovisnosti od sustava tova iz kojeg životinje potječu. Istraživanje je provedeno na uzorcima mišićnog tkiva (but i plećka) i jetre junadi u dobi od 9 do 12 mjeseci koja su tovljena ekstenzivno (n=12) ili intenzivno (n=12). Svaki uzorak je podijeljen na dva jednaka dijela od kojih je jedan analiziran u sirovom stanju, a drugi nakon termičke obrade kuhanjem u vodi na 100°C. Rezultati su iskazani u apsolutno suhoj tvari mesa. Sadržaj pepela (mineralnog ostataka) u termički obrađenim uzorcima bio je smanjen u odnosu na sirove uzorke, ali to nije bilo praćeno značajmeso junadi, termička obrada, minerali nim promjenama u sadržaju Fe, Zn i Cu u mišićnom tkivu, niti promjenama Zn i Cu u jetri. Termička obrada dovela je do smanjenja sadržaja Mg u svim ispitivanim partijama mesa (za 40-50%), a do smanjenja sadržaja Fe došlo je samo u jetri (za 25-42 %). Učinak termičke obrade na sadržaj ispitivanih minerala u mišićnom tkivu i jetri bio je neovisan od sustava tova, iako su razlike po sustavu tova bile evidentne kod svih ispitivanih minerala, osim kod Fe. Sadržaj Zn u mišićnom tkivu buta junadi iz ekstenzivnog tova bio je manji, a sadržaj Cu veći u odnosu na uzorke buta iz intenzivnog sustava tova. Suprotno od buta, u jetri je sadržaj Cu bio veći kod junadi iz intenzivnog tova. U svim ispitivanim partijama mesa iz ekstenzivnog tova sadržaj Mg je bio značajno veći nego kod junadi iz intenzivnog tova.
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Beauchemin, K. A., G. R. Bowman, L. M. Rode et M. A. G. von Keyserlingk. « Effects of feeding anionic products to non-lactating dairy cows on urine pH ». Canadian Journal of Animal Science 83, no 3 (1 septembre 2003) : 609–12. http://dx.doi.org/10.4141/a03-045.
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Anionic products (anionic salts, Bio-Chlor™, Nutri-Chlor™, and SoyChlor 16-7™ ) were fed to 12 non-lactating dairy cows and urine pH was monitored. The products differed in their effectiveness: anionic salts, Bio-Chlor, and Nutri-Chlor lowered urine pH, but SoyChlor was not effective. For cows fed once daily, checking urine pH 12 to 18 h after feeding is most likely to indicate nadir pH. Key words: Dietary cation-anion difference, urine acidification, urine pH, dairy cow, non-lactating
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Zalazar-Garcia, D., A. Fernandez, L. Rodriguez-Ortiz, R. Rodriguez et G. Mazza. « Sustainable Slow-Pyrolysis Simulation of 12 Lignocellulosic Bio-wastes : CO2 Emission, Energy, and Water Consumption ». IOP Conference Series : Earth and Environmental Science 952, no 1 (1 janvier 2022) : 012008. http://dx.doi.org/10.1088/1755-1315/952/1/012008.
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Abstract The development and increase of the agro-industrial activity generate bio-waste that represents significant quantities and causes environmental impacts, as residual effluents and solid wastes. These bio-wastes can be converted into different products through the pyrolysis processes (biochar, bio-oil, and gas). In this work, the pyrolysis at 673, 773, and 873 K of 12 types of bio-waste characterized by their elemental composition was assessed through the simulation process. Cape Open to Cape Open Simulator (COCO) free software was used in simulations. Thus, the biochar, bio-oil, and gas yields were predicted. Also, the energy, water consumption, and CO2 emission were calculated for each type of bio-waste. The marc and the stalk of white grape presented the highest biochar and bio-oil yields (30.7 and 53.1 %wt) at 673 K. The pistachio green shell presented the highest gas yield, 53.7 %wt at 873 K. The maximum energy consumption and CO2 emissions founded were 13.72 kWh and 3.72 kg/h for the stalk of white grape at 873 K respectively, while the lowest energy consumption and CO2 emission were 9.22 kWh and 2.31 kg/h for plum pits at 773 K respectively. The highest water consumption was 25.86 kg/h for the stalk of red grape at 773 K, while the lowest value was 14.30 kg/h for plum pits at 773 K.
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Asafu-Adjaye, Osei Asibe, Jason Street, Archana Bansode, Maria L. Auad, Maria Soledad Peresin, Sushil Adhikari, Terry Liles et Brian K. Via. « Fast Pyrolysis Bio-Oil-Based Epoxy as an Adhesive in Oriented Strand Board Production ». Polymers 14, no 6 (19 mars 2022) : 1244. http://dx.doi.org/10.3390/polym14061244.
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The objectives of this study were to utilize bio-oil-based epoxy resin in oriented strand board (OSB) production and investigate the effect of bio-oil substitution in epoxy resin as an adhesive for OSB production. Bio-oil was produced by the fast pyrolysis (FP) process using southern yellow pine (Pinus spp.). Bio-oil-based epoxy resin was synthesized by the modification of epoxy resin with FP bio-oil at various substitution levels. Acetone extraction using a Soxhlet process indicated a superior cured reaction of bio-oil and epoxy resin at 20% bio-oil substitution. FTIR spectra corroborated the Soxhlet extraction with the removal of the epoxide peak signature within the cross-linked polymer. Images from the scanning electron microscopy suggested bulk phase homogeneity. OSB panels were tested according to ASTM D1037-12. The modulus of rupture (MOR), modulus of elasticity (MOE), internal bond strength, and water resistance (thickness swell and water absorption) properties of the OSB panels were feasible at bio-oil substitution up to 30% in the epoxy resin system.
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Pusparizkita, Yustina M., Alif F. Hidayatullah, Norrisal F. Anwar, J. Junaidi et S. Sudarno. « Effect of drying duration on the water content of durian peel waste for bio pellet ». IOP Conference Series : Earth and Environmental Science 1098, no 1 (1 octobre 2022) : 012052. http://dx.doi.org/10.1088/1755-1315/1098/1/012052.
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Abstract Bio pellet is popular as an alternative solid fuel for replacing firewood and coal. In this study, the biomass used as raw material for making bio pellets is durian peel. Due to the high-water content, durian peel must be dried before being processed into a bio pellet. Therefore, this study aimed to analyze three variable time effects of drying duration at a temperature of 100°C on the water content of durian peel. The results showed that the water content of durian skin after drying for 6, 12, and 24 hours was 11,04%; 8,09%; and 3,75%. The most extended drying duration will produce the driest raw materials and the lowest moisture content. Nevertheless, the drying time that has the appropriate moisture content for the raw material for making pellets was 6 and 12 hours.
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Zhdanava, Maryia, Sumesh Kachroo, Aditi Shah, Zhijie Ding, Christopher Holiday, Patrick Lefebvre, Ruizhi Zhao, Caroline Kerner et Dominic Pilon. « REAL-WORLD USTEKINUMAB PERSISTENCE IN PATIENTS WITH ULCERATIVE COLITIS ATTAINING THE MAINTENANCE PHASE ». Inflammatory Bowel Diseases 29, Supplement_1 (26 janvier 2023) : S36—S37. http://dx.doi.org/10.1093/ibd/izac247.067.
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Abstract BACKGROUND Sustained use of biologics and small molecule/advanced therapy has proven to be effective for controlling disease activity in ulcerative colitis (UC). The anti-interleukin agent ustekinumab was recently approved for UC in 2019. This study aimed to describe real-world ustekinumab persistence among patients with UC attaining the maintenance phase. METHODS Adults with UC selected from the Komodo Health’s comprehensive dataset had the first claim for ustekinumab (index date) between 10/21/2019 and 08/13/2021. Patients had ≥12 months of continuous insurance eligibility pre-index (baseline period), ≥1 claim with a diagnosis of UC at baseline or on the index date and persisted to their first subcutaneous ustekinumab claim (maintenance phase). Patients with diagnoses for other immune disorders at baseline or diagnoses for Crohn’s disease at any time were excluded. Persistence to ustekinumab was defined as absence of a therapy exposure gap of >120 days between days of supply or end of follow-up. Composite endpoints were persistence while being corticosteroid-free (no corticosteroids with ≥14 days of supply after day 90 post-index), and persistence while on monotherapy (no immunomodulators/non-index biologics or advanced therapies). Persistence endpoints were described post-maintenance phase until the earlier of 12 months, end of insurance eligibility, or data. Kaplan-Meier curves were used to assess persistence outcomes in all patients and among patients without prior biologic/advanced therapy exposure pre-index (bio-naïve). RESULTS 778 patients attaining the ustekinumab maintenance phase were selected, 236 (30.3%) were bio-naïve (Fig. 1). Mean follow-up time post-index was 13.5 months overall and 12.7 months for bio-naïve patients. By 12 months post-maintenance, 73.2% of all patients and 75.5% of bio-naïve patients were persistent to ustekinumab (Fig. 2). Additionally, amongst patients who were persistent and corticosteroid-free between the index date and the start of maintenance phase, 47.0% of all patients and 55.1% of bio-naïve patients remained persistent and corticosteroid-free 12 months after their first maintenance claim. Further, among patients who were persistent on monotherapy at the start of maintenance phase, 63.6% of all patients and 68.1% of bio-naïve patients remained persistent on monotherapy at 12 months. CONCLUSIONS In this study, 12 months after their first ustekinumab maintenance claim for UC, most patients who attained the maintenance phase were persistent to treatment, around half of patients who were also corticosteroid-free at the start of the maintenance phase remained persistent and corticosteroid-free, and most patients who were persistent on monotherapy at the start of the maintenance phase remained persistent on monotherapy.
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Luo, Zeyu, Guosheng Tang, Hossein Ravanbakhsh, Wanlu Li, Mian Wang, Xiao Kuang, Carlos Ezio Garciamendez‐Mijares et al. « Vertical Extrusion Cryo(bio)printing for Anisotropic Tissue Manufacturing (Adv. Mater. 12/2022) ». Advanced Materials 34, no 12 (mars 2022) : 2270091. http://dx.doi.org/10.1002/adma.202270091.
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Baier, Johannes, Nina J. Blumenstein, Jan Preusker, Lars P. H. Jeurgens, Udo Welzel, Tuan A. Do, Jürgen Pleiss et Joachim Bill. « The influence of ZnO-binding 12-mer peptides on bio-inspired ZnO formation ». CrystEngComm 16, no 24 (2014) : 5301. http://dx.doi.org/10.1039/c4ce00520a.
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Kumar, Manoj, et Raj Kumar. « A Ultra Low Power 12 Bit Successive Approximation Register for Bio-Medical Applications ». International Journal of Engineering & ; Technology 7, no 3.16 (26 juillet 2018) : 98. http://dx.doi.org/10.14419/ijet.v7i3.4.16192.
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Successive Approximation Register (SAR) analog to digital Converters (ADC) is favorable choice for the high resolution. As resolution of ADC increases, the no. of redundant cycles increases which increases power. So the Paper presents clock gated ADC with no redundant cycles/transition cycles for low power requirement and comparison between without Clock Gating and Clock Gated SAR. Using Simulation, Power consumption for Clock gated SAR 736.1nW at 1.8V power supply where as without Clock Gating SAR consumption is 54µW at 1.8 power supply.
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McAteer, Martina A., David C. Grimsditch, Martin Vidgeon-Hart, G. Martin Benson et Andrew M. Salter. « Dietary cholesterol reduces lipoprotein lipase activity in the atherosclerosis-susceptible Bio F1B hamster ». British Journal of Nutrition 89, no 3 (mars 2003) : 341–50. http://dx.doi.org/10.1079/bjn2002802.
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We have compared lipoprotein metabolism in, and susceptibility to atherosclerosis of, two strains of male Golden Syrian hamster, the Bio F1B hybrid and the dominant spot normal inbred (DSNI) strain. When fed a normal low-fat diet containing approximately 40 g fat and 0·3 g cholestero/g, triacylglycerol-rich lipoprotein (chylomicron+VLDL) and HDL-cholesterol were significantly higher (P<0·001) in Bio F1B hamsters than DSNI hamsters. When this diet was supplemented with 150 g coconut oil and either 0·5 or 5·0 g cholestero/g, significant differences were seen in response. In particular, the high-cholesterol diet produced significantly greater increases in plasma cholesterol and triacylglycerol in the Bio F1B compared with the DSNI animals (P=0·002 and P<0·001 for cholesterol and triacylglycerol, respectively). This was particularly dramatic in non-fasting animals, suggesting an accumulation of chylomicrons. In a second experiment, animals were fed 150 g coconut oi/g and 5·0 g cholestero/g for 6 and 12 months. Again, the Bio F1B animals showed dramatic increases in plasma cholesterol and triacylglycerol, and this was confirmed as primarily due to a rise in chylomicron concentration. Post-heparin lipoprotein lipase activity was significantly reduced (P<0·001) in the Bio F1B compared with the DSNI animals at 6 months, and virtually absent at 12 months. Bio F1B animals were also shown to develop significantly more (P<0·001) atherosclerosis. These results indicate that, in the Bio F1B hybrid hamster, cholesterol feeding reduces lipoprotein lipase activity, thereby causing the accumulation of chylomicrons that may be associated with their increased susceptibility to atherosclerosis.
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de Oliveira e Silva, Marcelo, André Antonio Pelegrine, Alexandre Alves Pinheiro da Silva, Luiz Roberto Manhães Júnior, Rafael de Mello e Oliveira, Silvana Gaiba França, Antonio Carlos Aloise et Lydia Masako Ferreira. « Xenograft Enriched with Autologous Bone Marrow in Inlay Reconstructions : A Tomographic and Histomorphometric Study in Rabbit Calvaria ». International Journal of Biomaterials 2012 (2012) : 1–7. http://dx.doi.org/10.1155/2012/170520.
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Objective. The aim of this study was to evaluate the bone healing after the usage of a scaffold enriched with bone marrow.Study Design. Ten rabbits were divided into 2 groups of 5 animals. Bilateral 12 mm diameter defects were created in the parietal bones. In control group Bio-Oss were inserted in both defects and, in experimental group, Bio-Oss enriched with autologous bone marrow were inserted in both defects. In these two groups, one of the calvarial defects was covered with Bio-Gide. The rabbits were sacrified 8 weeks after surgery and both CT and histomorphometric analysis were done.Results. The CT showed a lower remaining defect area in the experimental group covered with Bio-Gide when compared with control group, with and without Bio-Gide. The histomorphometrics showed no difference between groups regarding the non-vital mineralized tissue area. For vital mineralized tissue area, the experimental group covered with Bio-Gide obtained a higher percentage area when compared with control group, with and without Bio-Gide. For non-mineralized tissue area, the experimental group covered with Bio-Gide obtained a lower percentage area when compared with control group, with and without Bio-Gide.Conclusion. Both autologous bone marrow and membrane can contribute to the enhancement of bone healing.
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Ferreira, Carlos Eduardo de Almeida, Roberto Carlos Bodart Brandão, Carolina Borges Martinelli et Túlio Bonna Pignaton. « Improving gingival smile by means of guided bone regeneration principles ». Dental Press Journal of Orthodontics 21, no 3 (juin 2016) : 116–25. http://dx.doi.org/10.1590/2177-6709.21.3.116-125.sar.
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ABSTRACT Objective: This study evaluated the effectiveness of guided bone regeneration (GBR) carried out with xenogenic bone substitute (Bio-OssTM) and collagen resorbable membrane (Bio-GideTM) to improve gingival smile (GS) in patients with excessive vertical maxillary growth (EVMG). Methods: Twelve healthy women aged between 20 and 49 years old (mean age of 26 years), with 5 mm or more of gingival exposure during fully posed smile (FPS) due to EVMG, were included. Baseline digital photographs were taken with standardized head position at rest and FPS. In eight out of 12 cases, crown lengthening procedure was indicated and the initial incision was made 2 to 4 mm from the gingival margin. In four cases, with no indication for crown lengthening procedure, a sulcular incision was performed. GBR was performed in all cases, using micro screws and/or titanium mesh associated with Bio-OssTM and Bio-GideTM. After 10 days, sutures were removed. Recall appointments were scheduled at 1, 6, and 12 months when standardized photographs were again taken. ImageToolTM software was used to measure the gingival exposure (GE) during FPS from the standardized close-up smile photographs at baseline and 12 months. Results: GE mean at baseline was 275.44 mm2. After 12 months, patients who undergone exclusively GBR procedure, presented GE reduction of 40.7%, ∆ = 112.01 mm2 (statistically significant, p = 0.12), and patients who had crown lengthening associated with the graft had a reduction of 60%, ∆ = 167.01 mm2. Conclusion: Our results using GBR to improve GS in cases of EVMG showed an exceptionally high patient acceptance and satisfaction. One-year follow-up confirmed stable results.
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Lisangan, Meike Meilan, Rizal Syarie, Winiati Pudji Rahayu et Okky Setyawati Dharmaputra. « AKTIVITAS ANTIAFLATOKSIN B1 EKSTRAK DAUN RUMPUT KEBAR (Biophytum petersianum) TERHADAP Aspergillus flavus (Antiaflatoxin B1 Activity of Kebar Grass (Biophytum petersianum) Leaf Extract on Aspergillus flavus) ». Jurnal Agritech 35, no 01 (4 mai 2015) : 9. http://dx.doi.org/10.22146/agritech.9414.
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Aflatoxin B1 was a secondary metabolite produced by Aspergillus flavus having negative effect on human health because of its carcinogenic. Many efforts have been done to investigate the antifungal and antiaflatoxin agent derived plant. The objective of this research was to study the activity of antifungal from kebar grass leaf extract on mycelial growth and aflatoxin B1 production of Aspergillus flavus BCC F0219 and A. flavus BIO 2236 isolates in food model medium i.e. carbohydrate-enriched medium, fat-enriched medium and protein-enriched medium. Kebar grass leaf extracts was successively obtained by using n-hexane - ethyl acetate - methanol (HEM). Concentrations of the extract tested on A. flavus BCC F0219 and A. flavus BIO 2236 were 1; 1.5, and 2 MIC. The MIC for A. flavus BCC F0219 in carbohydrate-enriched medium, fat-enriched medium, and protein-enriched medium were 12, 14, and 14 mg/mL, respectively. Meanwhile, the MIC for A. flavus BIO 2236 in carbohydrate-enriched medium, fat-enriched medium and protein-enriched medium were 12, 16 and 16 mg/mL, respectively. The results showed that the percentage of growth inhibition of A. flavus BCC F0219 and BIO 2236 in carbohydrate, fat and protein-enriched medium at 3 different levels of MIC concentrations ranged between 90.8 - 100% and 93.8 - 100%. The inhibitory effect of Aflatoxin B1 production of A. flavus F0219 BCC and BIO 2236 in carbohydrate, fat and protein-enriched medium at 3 different levels of MIC concentration ranged between 70.86 - 100 % and 83.42 – 98.84 %.Keywords: Aflatoxin B1, anti aflatoxin, Aspergillus flavus, Biophytum petersianum, food model medium, kebar grass ABSTRAKAflatoksin B1 merupakan metabolit sekunder yang dihasilkan oleh Aspergillus flavus yang berbahaya bagi kesehatan karena bersifat karsinogenik. Berbagai upaya telah dilakukan untuk mencari bahan antikapang dan antiaflatoksin yang berasal dari bahan alami seperti tumbuhan. Tujuan penelitian ini adalah mempelajari aktivitas ekstrak daun rumput kebar terhadap pertumbuhan miselium dan produksi aflatoksin B1 dari isolat A. flavus BC F0219 dan A. flavus BIO2236 pada media model pangan kaya karbohidrat, lemak dan protein. Ekstrak daun rumput kebar diekstraksi secara bertingkat dengan pelarut n-heksana-etil asetat-metanol (HEM). Konsentrasi ekstrak yang diuji untuk isolatA. flavus BCC F0219 dan A. flavus BIO 2236 masing-masing adalah 1; 1,5; dan 2 MIC (Minimum Inhibitory Concentration).NilaiMIC untuk A. flavus BCC F0219 pada media kaya karbohidrat, lemak, dan protein berturut-turut sebesar 12, 14, dan 14 mg/mL. Sedangkan nilai MIC untuk A. flavus BIO 2236 pada media kaya karbohidrat, lemak, dan protein berturutturut sebesar 12, 16, dan 16 mg/mL. Hasil pengujian memperlihatkan bahwa persentase hambatan pertumbuhan isolat A.flavus BCC F0219 dan BIO 2236 pada media kaya karbohidrat, lemak dan protein pada 3 tingkat konsentrasi MIC berkisar antara 90,8 – 100% dan 93,8 – 100%. Hambatan produksi aflatoksin B1 isolat A. flavus BCC F0219 dan BIO 2236pada media kaya karbohidrat, lemak dan protein pada 3 tingkat konsentrasi MIC berkisar antara 70,86 – 100% dan 83,42 – 98,84%.Kata kunci: Aflatoxin B1, anti aflatoksin, Aspergillus flavus, Biophytum petersianum, media model pangan, rumput kebar
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Chaparro, M., A. Armuzzi, P. M. Irving, M. Allez, M. C. Dubinsky, B. E. Sands, M. Goetsch et al. « DOP42 Efficacy of etrasimod on symptomatic relief in patients with ulcerative colitis : an analysis of the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials ». Journal of Crohn's and Colitis 17, Supplement_1 (30 janvier 2023) : i107—i110. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0082.
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Abstract Background Patient-reported outcomes such as stool frequency (SF) and rectal bleeding (RB) are important measures of ulcerative colitis (UC) activity and treatment effect. Etrasimod is an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator in development for the treatment of moderately to severely active UC. We evaluated RB and SF subscores to assess symptomatic relief in the ELEVATE UC phase 3 programme. Methods In ELEVATE UC 52 (NCT03945188) and ELEVATE UC 12 (NCT03996369), patients (16-80 years) with moderately to severely active UC were randomised 2:1 to once-daily etrasimod 2 mg or placebo (PBO). ELEVATE UC 52 utilized a treat-through design comprising a 12-week induction period followed by a 40-week maintenance period. ELEVATE UC 12 comprised a 12-week induction period. A key secondary endpoint was the proportion of patients with symptomatic remission (SF =0 [or =1 with a ≥1-point decrease from baseline] and RB =0) at week 12 and at week 52. RB and SF subscores, achievement of symptomatic remission, complete symptomatic remission (SF =0 and RB =0), and symptomatic response (≥30% decrease from baseline in composite RB/SF subscores) were assessed at each visit. Achievement of symptomatic remission was also summarized by subgroups in patients with prior biologic/Janus kinase inhibitor (bio/JAKi) use (yes [1, >1], no) and baseline corticosteroid use (yes, no). Results More etrasimod- vs PBO-treated patients achieved symptomatic remission by week 2 in ELEVATE UC 52 (15.3% vs 8.9%; P=0.049) and week 4 in ELEVATE UC 12 (27.5% vs 16.1%; P=0.007). Symptomatic remission increased in etrasimod- vs PBO-treated patients at each time point through week 12 in both ELEVATE UC 52 (46.0% vs 21.5%; P<0.001) and ELEVATE UC 12 (46.8% vs 29.5%; P=0.001) and was maintained through week 52 in ELEVATE UC 52 (43.4% vs 18.5%; P<0.001) (Figure 1A). Achievement of symptomatic response (Figure 1B), and significant improvements in RB and SF subscores, began as early as week 2 or week 4 for etrasimod vs PBO in ELEVATE UC 12 and ELEVATE UC 52, respectively. A significant difference in complete symptomatic remission was achieved at week 4 in both studies (Figure 1C). Subgroup analyses of symptomatic remission suggested a trend towards greater benefit in patients who were bio/JAKi naïve and patients with 1 prior bio/JAKi (vs >1) (Figures 2A-C). Conclusion In this analysis, symptomatic relief was achieved by a greater proportion of patients treated with etrasimod vs PBO as early as week 2 and was sustained through week 52. At week 2, symptomatic response and improvements in RB and SF subscores were observed. The greatest benefits were seen in patients who had no prior exposure to bio/JAKi or 1 prior bio/JAKi therapy.
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Russo, Vincent M., et Wayne W. Fish. « Efficacy of Microbial Amendments on Vegetables in Greenhouse and Field Trials ». HortScience 47, no 3 (mars 2012) : 349–55. http://dx.doi.org/10.21273/hortsci.47.3.349.
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Possible effects of microbe-containing amendments on vegetable development need clarification. Eight-week-old, organically grown seedlings of a bell, cv. Jupiter, and a non-pungent jalapeño, cv. Pace 105, pepper, both C. annuum L., were transplanted into pots containing an organic potting medium in a greenhouse experiments repeated over 2 years. Pots were fertilized with Neptune's Harvest®, a fish emulsion. One of eight amendments [Actinovate AG®, Bio Inoculant®, Bio-S.I.®, Compost Tea® (a decoction of biological material), Mpact®, ‘PMSLA and EO-12’®, Soil Activator®, Super Bio®] was applied at label rates and application timings. The control was Neptune's Harvest only. Three plants from each treatment were periodically harvested. Heights and total fresh and dry weights were determined. At a single terminal harvest, numbers and weights and chlorophyll, carotenoids, and vitamin C contents of fruit were determined. At the conclusion of the study the control, Bio-S.I., Compost Tea, PMSLA and EO-12, and Soil Activator generally produced bell pepper plants that were taller and heavier than those produced by Actinovate AG, Bio Inoculant, Mpact, and Super Bio. Numbers and weights of bell pepper fruit were not consistent over amendments or years. Heights for cv. Pace 105 plants treated with Compost Tea were similar to the control and taller than all others. Plant fresh weights for the control and Compost Tea were similar to that for Bio-S.I. and greater than all others. Dry weight, number and fresh weight of fruit and levels of chlorophylls, carotenoids, and vitamin C in fruit were unaffected. Compost Tea, PMSLA, and Soil Activator were tested in field trials in 2010 and 2011 using both peppers, cucumber (Cucumis sativus L.), cv. Earli Pik, and sweet corn (Zea mays var. rugosa Bonaf), cv. Incredible. Amendments provided no particular benefits under greenhouse or field conditions.
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Viraragavan, Amsha, Nokulunga Hlengwa, Dalene de Beer, Sylvia Riedel, Neil Miller, Sandra Bowles, Beata Walczak, Christo Muller et Elizabeth Joubert. « Model development for predicting in vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control ». Food & ; Function 11, no 4 (2020) : 3084–94. http://dx.doi.org/10.1039/c9fo02480h.
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Sapart, E., T. Sokolova, S. De Montjoye, S. Dierckx, A. Nzeusseu Toukap, A. Avramovska, L. Meric de Bellefon et P. Durez. « OP0119 SHOULD WE USE BIODMARDS IN FIRST INTENTION IN EARLY RHEUMATOID ARTHRITIS ? : RESULTS AT 5 YEARS FROM THE ERA LOUVAIN BRUSSELS COHORT ». Annals of the Rheumatic Diseases 80, Suppl 1 (19 mai 2021) : 66.2–67. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2314.
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Background:Early effective treatment has led to major improvements in patients with rheumatoid arthritis (ERA). Low disease activity and remission are achieved earlier and in higher frequency when the initial treatment in rheumatoid arthritis includes a combination of methotrexate (MTX) with a bDMARD compared to MTX alone.Objectives:The aim of this study is to retrospectively analyse and compare the benefit of a treatment with methotrexate (MTX) alone or combined with a bDMARD as an induction therapy during 5 years of follow-up in early rheumatoid arthritis (ERA) patients.Methods:We included ERA patients from the UCLouvain Brussels cohort who met the ACR/EULAR 2010 classification criteria and were naïve to DMARDs. Treatments were initiated based on the decision of a senior rheumatologist. bDMARDs induction therapy was usually limited to 6 or 12 months. We collected patient characteristics at baseline and clinical response was analysed at 6 months, 1 year, 3 years and 5 years.Results:Data from 470 eligible ERA patients were collected. The average age of the population is 48.9 years; 70.5% of the patients are women; 27.3% are smokers and 68.8% are positive for anti-citrullinated protein antibody (ACPA). 281 patients (59.8 %) initiated MTX as a monotherapy (MTX group) compared to 189 patients (40.2%) who received a bDMARD (Bio group).At baseline, the disease activity is the main factor that favors the initiation of bDMARDs (DAS28-CRP 5.2 vs 4.5, p<0.001) followed by HAQ (1.32 vs 1.15, p=0.009), ACPA positivity (77.8% vs 62.5%, p=0.0006), rheumatoid factor positivity (71.5% vs 60.2%, p=0.0134). Other parameters such as age, gender, smoking habits or baseline erosion were similar between groups.391 patients were followed up to 5 years. We then divided each of the two groups into two subgroups according to the last treatment they received at 5 years. Figure 1 shows the percentage of DAS28-CRP remission during time in each of the four groups (MTX->MTX (n=134), MTX->BIO (n=103); BIO->MTX (n=95), BIO->BIO (n=59);Figure 1.DAS28-CRP remission rate during time in each of the four groups (MTX->MTX (n=134), MTX->BIO (n=103); BIO->MTX (n=95), BIO->BIO (n=59).At 12 months, DAS28-CRP response rate was statistically significantly higher in MTX>MTX and BIO>MTX groups compared to the two other groups. As expected, the remission rate was rescued in the group MTX->Bio after 12 months.Interestingly, ERA patients initially treated by a bDMARD followed by a MTX maintenance therapy experienced a stable and sustained rate of remission.Conclusion:Longterm remission is an achievable goal in ERA followed in daily clinic. Our results suggest that a bDMARD induction therapy followed by MTX maintenance therapy could be a good option in severe case of ERA.References:[1]Smolen JS and al. D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020 Jan 22.Disclosure of Interests:None declared
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Sangian, Hanny F., et Seni Tongkukut. « STUDY OF BIO-ETHANOL PREPARATION FROM ARENGA PALM SUGAR ». JURNAL ILMIAH SAINS 15, no 1 (31 octobre 2011) : 259. http://dx.doi.org/10.35799/jis.11.2.2011.217.
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STUDY OF BIO-ETHANOL PREPARATION FROM ARENGA PALM SUGAR Hanny F. Sangian1), Seni Tongkukut1) 1) Deptartment of Physics, University of Sam Ratulangi Manado 95115 ABSTRACT This study purposes to prepare bio ethanol by using two column reflux distillation. In North Sulawesi has been known a very potential crop for yielding bio ethanol, is palm crop. Palm crops more productive than cane in yielding sugar and bio fuel per hectare. Its productivity about 4-8 times compared to cane, and its sugar rendement 14%, while cane only 7%. Based on this research were obtained the tapping process should be conducted by unique sequential steps in order to reach pH 8 and brix 12-14% of juice. By using of saccharomyzes ceraviseze and traditional technology was obtained fermented liquor with rate 35–42%. Prior to preparation two column reflux distillation apparatus had been designed and constructed successfully to prepare bio ethanol. Testing of bio ethanol preparation also is carried out by using two column distillation methods. Bio ethanol preparation used beer fermented from palm juice. High purity bio ethanol has been prepared successfully so far at Renewable Energy Lab University of Sam Ratulangi Manado. Surprised results were found that the ethanol purity varied from 95% to 99%. The highest purity is at of 99% by maintaining the column temperature of 78.5oC while purity of 95% is of 78.7oC Keywords: ethanol two column reflux distillation , fermentation, palm juice STUDI PEMBUATAN BIOETANOL DARI NIRA AREN ABSTRAK Studi ini bermaksud untuk membuat bio ethanol dengan menggunakan teknik destilasi dua kolom. Di Sulawesi Utara Indonesia telah dikenal tumbuhan yang dapat menghasilkan bio etanol yang disebut aren (arenga pinnata). Tumbuahan ini adalah lebih produktif menhasilkan gula dari pada tebu dilihat dari jumlah per hektarnya. Produktivitasnya adalah sekitar 4-8 kali dari pada tebu dengan rendemen gulanya sekitar 14%, sementara tebu hanya 7%. Berdasarkan hasil studi diperoleh bahwa proses penyadapan harus dilakukan dengan tahapan yang unik pada pH 8 dan brix 12-14%. Dengan menggunakan saccharomyzes ceraviseze dan teknologi tradisional diperoleh beer dengan kadar 35–42%. Sebelum pembuatan etanol, didahului dengan desain dan konstruksi peralatan destilasi refluks dua kolom. Dari hasil pembuatan didapat hasil yang sangat baik. Bio etanol kemurnian tinggi telah diperoleh dengan sukses selam studi ini. Hasil mengejutkan diperoleh bahwa kemurnian etanol bervariasi dari 95% sampai 99%. Kemurnian tertinggi adalah pada 99%dengan mempertahankan temperatur kolom 78.5oC sementara kemurnian 95% adalah pada 78.7oC. Kata kunci: fermentasi, air nira, etanol, destilasi dua kolom
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Charde, U. M., V. S. Shinde et S. R. Dhonde. « Bioefficacy of fungicides and bioagents against Macrophomina phaseolina causing charcoal rot in maize ». INTERNATIONAL JOURNAL OF AGRICULTURAL SCIENCES 17, no 2 (15 juin 2021) : 149–55. http://dx.doi.org/10.15740/has/ijas/17.2/149-155.
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In recent years Macrophomina phaseolina causing charcoal rot of maize is more problematic in maize growing parts of Maharashtra. Present investigation was taken on evaluation of fungicides and bio-agents against M. phaseolina under laboratory condition and pot culture. Under laboratory condition, nine fungicides and six bio- agents were evaluated against M. phaseolina by poison food technique and dual culture method, respectively. Among fungicides Carbendazim 63 % + Mancozeb 12% and Carbendazim alone recorded maximum inhibition of (100 %) mycelial growth. Among the bio-agents tested Trichoderma harzianum was found more effective as compared to other bio-control agents and inhibited maximum fungal growth (63.33 %) of M. phaseolina. Under pot culture study, as soil application and seed treatment, among the fungicides, carbendazim + Mancozeb was found most effective. However, among bioagents Trichoderma harzianum was remarkably manage the charcoal rot.
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Bongers, Coen C. W. G., Dominique S. M. Ten Haaf, Milène Catoire, Bregina Kersten, Jeroen A. Wouters, Thijs M. H. Eijsvogels et Maria T. E. Hopman. « Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain : a randomized controlled trial ». Applied Physiology, Nutrition, and Metabolism 45, no 7 (juillet 2020) : 793–800. http://dx.doi.org/10.1139/apnm-2019-0654.
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The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167; aged 63 [interquartile range = 56–68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks. Knee pain and function were measured with the Visual Analog Scale (VAS), the Lysholm questionnaire, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Furthermore, we assessed changes in inflammatory, cartilage, and bone (bio)markers. Measurements were conducted at baseline and after 12 weeks of supplementation. Baseline VAS did not differ between CP and placebo (4.7 [2.5–6.1] vs. 4.7 [2.8–6.2], p = 0.50), whereas a similar decrease in VAS was observed after supplementation (−1.6 ± 2.4 vs. −1.9 ± 2.6, p = 0.42). The KOOS and Lysholm scores increased after supplementation in both groups (p values < 0.001), whereas the increase in the KOOS and Lysholm scores did not differ between groups (p = 0.28 and p = 0.76, respectively). Furthermore, CP did not impact inflammatory, cartilage, and bone (bio)markers (p values > 0.05). A reduced knee pain and improved knee function were observed following supplementation, but changes were similar between groups. This suggests that CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. Novelty CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. CP supplementation over a 12-week period does not impact on inflammatory, cartilage, and bone (bio)markers in healthy, active, middle-aged to elderly individuals.
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Katayama, K., T. Okubo, T. Sato, R. Fukai, M. Yuichi, K. Yujiro et H. Ito. « AB0298 LONG-TERM SUPPRESSION OF RAPID RADIOGRAPHIC PROGRESSION AFTER DISCONTINUATION/REDUCTION OF SHORT-TERM BIOLOGIC THERAPY IN PATIENTS WITH EARLY DESTRUCTIVE RHEUMATOID ARTHRITIS ACCOMPANIED WITH EXTENSIVE BONE MARROW EDEMA. » Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 1448–49. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3187.
Texte intégralRésumé :
Background:We reported that short-term (3 or 6 months) treatment with biologics (BIO) group compared with conventional synthetic non-biological disease-modifying anti rheumatic drug (csDMARDs) enhanced group is more effective in the reducing bone marrow edema (BE) and improving structural remission in early destructive RA accompanied with extensive hand BM despite csDMARDs therapy (1).Objectives:Purpose of this extended study is to investigate whether suppression of RRP will maintain after the discontinuation/reduction of short term biological treatment during over 1 year. Clinical registration number; (UMIN-CTR 000013614)(Figure 1)Methods:RA disease activity was evaluated by DAS28-ESR after BIO withdrawal/reduction at 12 months. Bone destruction was determined by modified total Sharp scoring (mTSS) using by conventional radiography expressed as yearly progression of mTSS (ΔmTSS/y) at 12 months. Statistical analysis were performed by t-test or Wilcoxon rank sum test using SAS .13.2 softwareResults:Fourteen out of 23 patients in BIO group achieved improvement of BM (>70% improvement of baseline BE). Three patient continued BIO. Among 11 patient started to discontinuation/reduction of BIO, 7 patients were successful for discontinuation of BIO. Four patients flared (Table 1). Mean DAS28-ESR, mean ΔmTSS/y at 0, 12 months after discontinuation in 7 patients were 1.77, 2.02 and -0.66,-0.44, respectively (no significant difference between values in 0 and12 month). In contrast, those in 4 flared patients were 1.91, 4.08 and 0, 1.83, respectively (significant difference). Finally, to resolve baseline prognostic factors for improvement of BE for biological treatment, we compared baseline data between 14 BE improved and 9 BE unimproved RA patients. Low DAS28-ESR at 3 or 6 month (P<0.001) are indicated for significant prognostic factor for improvement of BE, although Low DAS28-ESR at baseline (P=0.07) may associate improvement of BE.Table 1.Summary of 1 year clinical data in 11 patients treated in BIO discontinuation/reduction after improvement of BE by short-term treatment of BIOConclusion:Results of this study indicated suppression of RRP will maintain during over 1 year after the discontinuation of short term biological treatment in some patients. We recommend that a short-term treatment with biologics for early RA patients, who are resistant to non-bio DMARDs therapy and at high risk to transit to RRP, will be an effective and economical treatment strategy.References:[1]K. Katayama, T. Okubo, S. Sato et al. Prevention of extensive bone marrow edema and consequent rapid radiographic progression by short term usage of biologics in DMARDs resistant patients with early destructive rheumatoid arthritis. EULAR meeting. FRI 0124(2018).Disclosure of Interests:None declared
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Yang, Xue, Lei Wen, Xiang Liu, Si Chen, Yayi Wang et Chunli Wan. « Bio-augmentative volatile fatty acid production from waste activated sludge hydrolyzed at pH 12 ». RSC Advances 5, no 62 (2015) : 50033–39. http://dx.doi.org/10.1039/c5ra04651c.
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Although many pretreatment methods are employed to enhance the hydrolysis of waste activated sludge (WAS), the bioconversion of soluble complex substrates needs improvement to produce higher volatile fatty acids (VFAs).
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Davies, W. J., M. S. Le et C. R. Heath. « Intensified activated sludge process with submerged membrane microfiltration ». Water Science and Technology 38, no 4-5 (1 août 1998) : 421–28. http://dx.doi.org/10.2166/wst.1998.0684.
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A pilot bio-reactor based on the Kubota membrane filtration system using screened domestic sewage has shown impressive results. Operating with an average MLSS of 16,000 mg/l and 4.5 hours HRT the bio-reactor produced a very high quality effluent with typical values of 4 mg/l and 5 mg/l for BOD and NH4-N respectively. The sludge age from the bio-reactor was about 45 days. The cost of secondary treatment by membrane bio-reactor (including land and civil costs) starts from 12 p/m3 for a 1.4 Ml/d plant and reduces to 6p/m3 for a 22.5 Ml/d plant based on full treatment up to 3DWF. The corresponding treatment costs by conventional technologies are 13 p/m3 for a 1.4 Ml/d SBC plant and 5 p/m3 for a 22.5 Ml/d FBDA activated sludge plant.
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Irawansyah, Herry, Apip Amrullah et Jayadi Fitrah. « The effect of temperature distillation on products distribution derived from wood pyrolysis bio-oil ». IOP Conference Series : Earth and Environmental Science 1038, no 1 (1 juin 2022) : 012019. http://dx.doi.org/10.1088/1755-1315/1038/1/012019.
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Abstract Bio-oil from biomass pyrolysis can be converted to chemicals, solid carbon materials, and syngas by various thermochemical conversion technology methods. Because of the elevated temperature, bio-oil suffers drastic component changes as the first step in these processes. Understanding the impact of heating temperature on bio-oil transformation during the distillation process is critical for practical bio-oil usage. A bio-oil feedstock produced from the pyrolysis of lamtoro wood residue at 500 °C was used in distillation from this work. Complete temperature range analysis of 96, 97, 98, 99, and 100 °C was conducted. Eight typical compounds in bio-oil were precisely quantified by gas chromatography-mass spectroscopy (GC-MS) and FTIR analysis. The results revealed that a common critical point was widely present during the distillation process, which may be attributed to a stable system generated by hydrogen bonding. As a result, the content of acetic acid, 2-Propanone, and phenol was up to 38%, 12%, and 20%, respectively. The detailed distillation characteristics and product distribution provide a comprehensive insight into the reaction process and component enrichment patterns, assisting design and parameter optimization.
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Liu, Xiao, Lin Wang et Jun Shi. « Micro-Polluted Surface Water Treated by Yeast-Chitosan Bio-Microcapsules ». Materials 13, no 16 (10 août 2020) : 3519. http://dx.doi.org/10.3390/ma13163519.
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Ammonia nitrogen and natural organic matter (NOM) seriously degrade the quality of surface waters. In this study, the optimum preparation conditions of a yeast-chitosan bio-microcapsule of the Candida tropicalis strain, used to treat micro-polluted surface water, were investigated. Fourier transform infrared spectroscopy and scanning electron microscopy were used to characterize the bio-microcapsules. A continuous laboratory-scale reaction apparatus was built to evaluate the engineering applications of the bio-microcapsules and their treatment efficiency for major pollutants in micro-polluted raw water. The yeast-chitosan bio-microcapsules were found to rapidly and effectively remove suspended solids and ammonia nitrogen. Moreover, the bio-microcapsule pre-treatment process was capable of resisting impact loads and fluctuations in water quality. Even at low temperatures (12 °C), the removal rate of ammonia nitrogen still reached 79%. The treatment did not lead to a temporary increase in nitrite concentration, nor to the excessive accumulation of nitrogen. The application of bio-microcapsules is simple; it only requires aeration and certain nutrient substrates, and can be adapted to treat raw drinking water with a poor nutrient substrate, therefore showing promise for future use in engineering applications.
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Nina, C., S. Nina et J. C. Quispe. « Análisis de componentes principales de bio-clima en Bolivia ». Ciencia Latina Revista Científica Multidisciplinar 6, no 5 (8 novembre 2022) : 4005–14. http://dx.doi.org/10.37811/cl_rcm.v6i5.3370.
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En este artículo se presentan los 19 bioclimas de Bolivia, registrados por entidades públicas en 89 localidades, para el estudio se disponen de 1691 datos. El objetivo del trabajo es identificar mediante componentes principales los bioclimas con mayor influencia en Bolivia. Los hallazgos revelan que existen dos componentes principales, PC1 y PC2 que explican el 76,58% y el 11,19% de la varianza total de los datos respectivamente. Los Bioindicadores BIO 6, BIO9, BIO 11, BIO 12 (Temperatura mínima del mes más Frío, Temperatura media del trimestre más frío, Temperatura media del trimestre más seco, Precipitación anual) aportan a la PC1; y BIO 3, BIO 4, BIO 5 (isotermalidad , estacionalidad en la temperatura, temperatura máxima del mes más cálido) aportan a la PC2. También se concluye que en las zonas de mayor elevación Potosí, Oruro, parte de Chuquisaca y La Paz, se ven afectadas significativamente por temperaturas frías en épocas secas y en las zonas que presentan menor elevación Santa Cruz, Beni y Tarija, existen localidades con temperaturas extremadamente cálidas con un cambio de temperatura mínimo. Las localidades de Bermejo e Ibibobo tienen la menor isotermalidad, manteniendo una temperatura casi constante durante todo el año.
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Arcens, Dounia, Gaëlle Le Fer, Etienne Grau, Stéphane Grelier, Henri Cramail et Frédéric Peruch. « Chemo-enzymatic synthesis of glycolipids, their polymerization and self-assembly ». Polymer Chemistry 11, no 24 (2020) : 3994–4004. http://dx.doi.org/10.1039/d0py00526f.
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This paper describes the synthesis of bio-based methacrylated 12-hydroxystearate glucose (MASG), and its (co)polymerization with methyl methacrylate (MMA) by either free- or RAFT radical polymerizations.
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Thompson, Alexis A., Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer et al. « Favorable Outcomes in Pediatric Patients in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy for the Treatment of Transfusion-Dependent β-Thalassemia ». Blood 136, Supplement 1 (5 novembre 2020) : 52–54. http://dx.doi.org/10.1182/blood-2020-135857.
Texte intégralRésumé :
Introduction Betibeglogene autotemcel (beti-cel; LentiGlobin for β-thalassemia) gene therapy is being evaluated for the treatment of transfusion-dependent β-thalassemia (TDT). Initial positive results of beti-cel in the phase 3 studies, HGB-207 (NCT02906202; non-β0/β0 genotypes) and HGB-212 (NCT03207009; β0/β0, β0/β+ IVS-I-110 and β+ IVS-I-110/β+ IVS-I-110 genotypes), showed 10/12 adult patients achieved transfusion independence. The studies expanded enrollment to include adolescents and children. We present interim results from pediatric patients <18 yrs who received beti-cel in HGB-207 and HGB-212 as of 3 March 2020. Methods After mobilization and apheresis, autologous CD34+ cells were transduced ex vivo with BB305 lentiviral vector, containing a modified human β-globin gene to produce beti-cel drug product (DP). Patients underwent busulfan myeloablation and infusion with beti-cel and were then followed longitudinally. Transfusion independence (TI; weighted average hemoglobin [Hb] ≥9 g/dL without transfusions for ≥12 mo) was the primary endpoint in HGB-207 and a secondary endpoint in HGB-212. Transfusion reduction (≥60% reduction in transfusion volume between Month 12 to 24 versus baseline) is the primary endpoint in HGB-212. Hb levels, TI characteristics, and quality of life were secondary endpoints. Assessments of ineffective erythropoiesis were exploratory. Data presented as median (min-max). Results Twenty-four pediatric patients were treated including 13 patients <12 yrs old (207: n=8; 212: n=5) and 11 patients ≥12 to <18 yrs old (207: n=6; 212: n=5). Patient, DP, and engraftment characteristics are described in the Table. All patients achieved neutrophil engraftment. Twenty-one patients with >3 mo follow-up achieved platelet engraftment and had platelets ≥100 x109/L by Month 12; one 17-yr old patient did not have platelets ≥100 x109/L until Month 15. In HGB-207, 6/7 (86%) patients <12 yrs and 6/6 (100%) patients ≥12 to <18 yrs with >3 mo follow-up have stopped transfusions for ≥6 mo. TI was achieved in 3/4 (75%) evaluable patients <12 yrs with weighted average Hb during TI of 10.0 (9.4-10.3) g/dL. At last visit, gene therapy-derived HbAT87Q in these patients was 5.1-7.1 g/dL. In patients ≥12 to <18 yrs, all 6 patients achieved TI with weighted average Hb during TI of 11.6 (11.3-12.3) g/dL. These patients had 8.4-10.5 g/dL HbAT87Q at last visit. Myeloid:erythroid (M:E) ratio in patients <12 yrs with TI improved from 1:3.7-1:1.1 at baseline to 1:2-1.5:1 at Month 12; in patients ≥12 to <18 yrs with TI, M:E ratio improved from 1:7.3-1.6:1 at baseline to 1:2.7-1.9:1 at Month 12. Patients <18 yrs who achieved TI in HGB-207 had an improved health state today score as assessed using EQ-5D-Y from 67 (50-96) at baseline (n=7) to 92.5 (85-95) at Month 12 (n=6). In HGB-212, 3/5 (60%) patients <12 yrs and 4/4 (100%) patients ≥12 to <18 yrs with >3mo follow-up have stopped transfusions for ≥6 mo. TI was achieved in 1/2 evaluable patients <12 yrs. Weighted average Hb during TI was 10.3 g/dL and HbAT87Q was 9.2 g/dL at last visit in this patient. All 3 evaluable patients ≥12 to <18 yrs achieved TI with weighted average Hb of 9.6 (9.5-12.8) g/dL. HbAT87Q in these patients was 8.0-10.9 g/dL at last visit. The M:E ratio in the patient <12 yrs with TI improved from 1:4.7 at baseline to 1.2:1 at Month 12. In the 2 patients ≥12 to <18 yrs with baseline and Month 12 assessments, M:E ratios improved from 1:5.1 to 1:1.4 and 1:3.3 to 1:1.8. Post-infusion non-hematologic grade ≥3 adverse events (AEs) in ≥3 patients aged <12 yrs in either study were febrile neutropenia (n=9), stomatitis (n=6), decreased appetite (n=4), increased alanine aminotransferase (n=3), and epistaxis (n=3); in patients ≥12 to <18 yrs, these were stomatitis (n=8), febrile neutropenia (n=3) and hypoxia (n=3). Grade 4 veno-occlusive disease occurred in 2 patients ≥12 to <18 yrs and one grade 2 event occurred in a patient <12 yrs; all cases were successfully treated with defibrotide. Neither replication-competent lentivirus, insertional oncogenesis, nor clonal dominance were observed. Summary Interim results in HGB-207 and HGB-212 show that after treatment with beti-cel, pediatric patients <18 yrs achieved transfusion independence with comparable rates as in adults, suggesting that beti-cel gene therapy represents an effective treatment option across ages. The safety profile of gene therapy with beti-cel was consistent with busulfan myeloablation. Disclosures Thompson: CRISPR/Vertex: Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Baxalta: Research Funding; BMS: Consultancy, Research Funding; Biomarin: Research Funding; bluebird bio, Inc.: Consultancy, Research Funding. Kwiatkowski:Novartis: Research Funding; Agios: Consultancy; Sangamo: Research Funding; bluebird bio,Inc.: Consultancy, Research Funding; Apopharma: Research Funding; Imara: Consultancy; BMS: Consultancy; Terumo Co: Research Funding; Celgene: Consultancy. Porter:Vifor Pharmaceuticals: Honoraria; bluebird bio, Inc.: Consultancy, Honoraria; Agios Pharmaceuticals: Consultancy, Honoraria; La Jolla Pharmaceuticals: Honoraria; Silence Therapeutics: Honoraria; Protagonist Therapeutics: Honoraria; BMS: Consultancy, Honoraria. Kulozik:Novartis: Consultancy, Honoraria; bluebird bio, Inc.: Consultancy, Honoraria. Thrasher:Rocket Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; Generation bio: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Equity ownership; Orchard Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Equity ownership; 4Bio Capital: Consultancy, Membership on an entity's Board of Directors or advisory committees. Thuret:Novartis pharma: Membership on an entity's Board of Directors or advisory committees, Other: Investigator in clinical trials; bluebird bio, Inc.: Membership on an entity's Board of Directors or advisory committees, Other: Investigator in clinical trials; Apopharma: Consultancy, Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees, Other: Investigator in clinical trials. Lal:Insight Magnetics: Research Funding; Celgene, BMS: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Research Funding; Terumo Corporation: Research Funding; Agios Pharmaceuticals: Consultancy; Chiesi USA: Consultancy; La Jolla Pharmaceutical Company: Research Funding; bluebird bio, Inc.: Research Funding; Protagonist Therapeutics: Membership on an entity's Board of Directors or advisory committees, Research Funding. Guo:bluebird bio, Inc.: Current Employment, Current equity holder in publicly-traded company. Liu:bluebird bio, Inc.: Current Employment, Current equity holder in publicly-traded company. Colvin:bluebird bio, Inc.: Current Employment, Current equity holder in publicly-traded company. Walters:Veevo Biomedicine: Consultancy; AllCells, Inc: Consultancy; Editas: Consultancy. Locatelli:Jazz Pharmaceeutical: Speakers Bureau; Medac: Speakers Bureau; Miltenyi: Speakers Bureau; Bellicum Pharmaceutical: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Amgen: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.
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Ariyanto, Eko, Muhammad Arief Karim et Agung Firmansyah. « BIOBRIKET ENCENG GONDOK (EICHHORNIA CRASSIPES) SEBAGAI BAHAN BAKAR ENERGI TERBARUKAN ». Reaktor 15, no 1 (27 février 2014) : 59. http://dx.doi.org/10.14710/reaktor.15.1.59-63.
Texte intégralRésumé :
Menipisnya cadangan energi fosil sebagai akibat dari meningkatnya pertumbuhan penduduk dan sektor industri. Biomassa dapat dianggap sebagai pilihan terbaik untuk energy alternatif terbarukan. Tujuan dari penelitian ini adalah untuk mengamati kemungkinan eceng gondok (Eichhornia crassipes) untuk diolah menjadi bio-briket. Penelitian briket dilakukan dengan menggunakan tepung tapioka dan lem kayu sebagai perekat. Dengan persentase perekat adalah 4%, 6%, 8%, 10%, dan 12%. Bio-briket yang dihasilkan diamati kadar air evalueted, kadar abu dan nilai kalor. Dari hasil penelitian menunjukkan bahwa nilai kadar air dan kadar abu meningkat dengan meningkatnya presentasi perekat pada bio-briket. Namun, nilai kalor mencapai titik maksimum 10% dan 8% untuk masing-masing penambahan tapioka strach dan lem kayu perekat.
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Ritter, T. E., H. E. Sarles, S. A. Mehta et L. J. Van Anglen. « P631 Predictors of vedolizumab treatment persistence in bio-naïve ulcerative colitis patients ». Journal of Crohn's and Colitis 14, Supplement_1 (janvier 2020) : S523—S524. http://dx.doi.org/10.1093/ecco-jcc/jjz203.759.
Texte intégralRésumé :
Abstract Background Vedolizumab (VDZ) is increasingly being positioned as first-line biologic therapy for the treatment of inflammatory bowel disease (IBD) in adults, particularly for ulcerative colitis (UC). Identifying a certain subset of bio-naïve UC patients most likely to benefit from VDZ and remain on long-term maintenance therapy is important. The purpose of this study was to evaluate predictors of VDZ treatment persistence at 12 months in real-world clinical practice. Methods We performed a retrospective review of all adult (≥18 years) bio-naïve UC patients started on VDZ at US gastroenterology physician office infusion centres. Data collection included baseline demographics, VDZ therapy, concomitant oral agents, disease severity, and disease activity scores using the partial Mayo score (pMayo). Disease severity was characterised by prior IBD-related surgery and IBD-related healthcare resource utilisation within 1 year of VDZ initiation. Clinical response was assessed at baseline, 6 weeks, and 14 weeks and defined as a pMayo reduction of ≥2 points. Patients were divided into two cohorts, those persisting on VDZ at 12 months and those discontinuing VDZ prior to 12 months. Logistic regression analysis was used to determine predictors associated with persistence. Results A total of 141 UC patients receiving VDZ as first-line biologic therapy were identified: mean age 44 ± 14.5 years, male gender 82 (58%), median disease duration 5.5 (IQR 1.6–13.3) years. VDZ treatment persistence at 12 months was observed in 102 (72%) patients (Figure 1). The remaining 39 patients discontinued VDZ within the first 12 months. Amongst those who discontinued VDZ, reasons included lack or loss of response in 35 (90%), antibodies in 3 (8%), and intolerance in 1 (3%). In the logistic regression analysis, the only factor associated with VDZ treatment persistence was clinical response at 14 weeks (OR 6.5 [95% CI 2.9–14.5]). No other variables (age, gender, smoking status, disease duration, concomitant oral agents, or severity of illness) influenced persistence at 12 months. Conclusion Almost three-fourths of bio-naïve UC patients treated with vedolizumab experienced treatment persistence at 12 months. Our data suggest that response to induction may be used to predict those who will remain on maintenance therapy.
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Zulkania, Ariany, Achmad Chafidz, Putri Maharani et Sinthya Ade Putri. « Effect of Acidic Activated Natural Zeolite on Characteristics of Bio Oil Derived from Pinus Merkusii’s Cone Pyrolysis ». Key Engineering Materials 818 (août 2019) : 99–103. http://dx.doi.org/10.4028/www.scientific.net/kem.818.99.
Texte intégralRésumé :
Due to diminishing fossil fuel, energy alternative availability becomes very crucial. Bio-oil is one of the alternative energy sources obtaining from the biomass pyrolysis process. This study's aim is to determine the effect of temperature and the addition of catalysts in the pyrolysis process. The catalyst was made of natural zeolite which was activated with an H2SO4 solution of 0.5 N and then heated at 350 °C for 12 hours. The pyrolysis of dry pine cone powder was run in a fluidized bed reactor enclosed by a furnace at a heating rate of 15 °C/min and residence time for 3 hours. From the existing variations, the largest bio-oil yield i.e. 34.28% was obtained from non-catalytic pyrolysis at the temperature of 500 °C, however, the bio-oil conceived high acids. On the other hand, the bio-oil comprised high phenolics and aromatics were generated from catalytic pyrolysis with 5% wt catalyst at a temperature of 500 °C. Eventually, the bio-oil from Pinus Merkusii cone has the potential to be biofuel and biochemical materials.
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Larionov, Yury S., Valeriy B. Zharnikov, Evgeniya I. Baranova, Gennady N. Kovalivker et Anatoly A. Kosov. « ELECTROMAGNETIC TREATMENT OF SEEDS AS A FACTOR OF THEIR GENETIC POTENTIAL MANAGEMENT ». Interexpo GEO-Siberia 4, no 2 (21 mai 2021) : 104–12. http://dx.doi.org/10.33764/2618-981x-2021-4-2-104-112.
Texte intégralRésumé :
In bio-agricultural technologies are considered additional factors that without chemical stimulants of plant growth by electromagnetic processing of seeds to increase yields from 12% to 30%, reducing the annual amount of applied mineral fertilizer required to produce one ton of grain, with the consistency of water resources for a specific field in a specific agro-ecological environment. The rationale for the inevitable transition to bio-agriculture due to the lack of water for agricultural production in the coming years is given.
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Dewita, Mira, Badriul Hegar Syarif et Sudigdo Sastroasmoro. « Evaluation of Bio M pylori serologic test and C-13 urea breath test for H. pylori infection in children with recurrent abdominal pain : a pilot study ». Paediatrica Indonesiana 50, no 2 (30 avril 2010) : 101. http://dx.doi.org/10.14238/pi50.2.2010.101-104.
Texte intégralRésumé :
Background Diagnosing Helicobacter pylori infection in childrenis still a problem. Urea breath test is the gold standard for noninvasivediagnostic test, but it is expensive and not available inmost hospitals. The Bio M Pylori serologic test has good diagnosticvalue in adults, less expensive and more practical, but had neverbeen evaluated in children.Objective To determine the prevalence of H. pylori infection andthe diagnostic accuracy of Bio M Pylori serologic test in childrenwith recurrent abdominal pain.Methods This study was conducted in May - June 2009. Childrenaged 12-15 years with recurrent abdominal pain were examinedwith urea breath test and the Bio M Pylori serologic test.Sensitivity, specificity, area under the curve (AUC), predictivevalues, and likelihood ratios were calculated for the Bio M Pyloriserologic test.Results Most subjects aged 13 years (83%). Girls outnumberedboys, and most were undernourished. The prevalence ofH. pyloriinfection detected by urea breath test and Bio M Pylori serologictest was 8% and 52%, respectively. The Bio M Pylori serologictest had sensitivity and specificity of 100% and 53%, respectively.Area under the curve (AUC) was 0.764. Positive and negativepredictive values were 16 and 100%, whereas positive andnegative likelihood ratios are 2.12 and 0. The overall accuracyof this test is 5 7%Conclusions The Bio M Pylori serologic test has high sensitivityvalue (100%). This diagnostic kit can be considered as a goodpre-endoscopic screening tool in children with recurrentabdominal pain caused by H. pylori infection.
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İri, Rüçhan, Gürkan Yılmaz et Emrah Şengür. « 12-15 yaş futbolcuların motor beceri düzeylerinde biyo-gruplama önemli midir ? » Journal of Human Sciences 18, no 4 (27 décembre 2021) : 704–14. http://dx.doi.org/10.14687/jhs.v18i4.6245.
Texte intégralRésumé :
Chronological age is used as a basis for determining and comparing the motor skill levels of football players. However, it is known that there are early maturing and late maturing players in the same age group. The aim of this study is to compare the motor skill levels of football players in the same age group by bio-banding and to investigate the importance of bio-banding on motor skill levels. 81 male football players between the ages of 12-15 participated in the study voluntarily. Gross motor skills of the football players participating in the study were determined with Deutscher Motoric Test (DMT 6-18), which consists of 8 tests, namely, (DMT20m sprint, DMTside jump, DMTflexibility, DMT standing long jump, DMT sit-up, DMTbalance, DMT push-up, DMT6 min running). Bio-banding was used to determine the maturity level of football players. As a result of the study, it was determined that there are football players with different maturity levels in the same chronological age grouping. There was no difference in the comparison of sprint, side jump, flexibility, push-up variables between groups according to bio-banding. There was a significant difference in the comparison of balance, sit-up, standing jump and running variables between groups according to bio-banding. It was determined that it was in favor of prepubertal in the sit-up variable, and in favor of pubertal in the balance and sit-up, running and standing jump variables. As a result, it has been determined that there are football players with different maturation levels in the same age group in the bio-bandinged football players, and this situation affects the motor skill levels. It is recommended to use bio-grouping in addition to chronological age when determining the motor skill levels of athletes in all team sports, especially football players. Extended English summary is in the end of Full Text PDF (TURKISH) file. Özet Kronolojik yaş futbolcuların motor beceri düzeylerinin belirlenmesinde ve karşılaştırılmasında temel olarak kullanılmaktadır. Fakat aynı yaş grubu içerisinde erken olgunlaşan ve geç olgunlaşan futbolcuların olduğu bilinmektedir. Bu çalışmanın amacı aynı yaş grubu içerisinde yer alan futbolculara biyo-gruplama yapılarak motor beceri düzeylerinin karşılaştırılması ve biyo-gruplamanın motor beceri düzeyleri üzerine öneminin araştırılmasıdır. Çalışmaya 12-15 yaş arası 81 erkek futbolcu gönüllü olarak katılmıştır. Çalışmaya katılan futbolcuların kaba motor becerileri 8 testten oluşan Deutscher Motorik Test (DMT 6-18) (DMT20m sprint, DMTyana sıçrama, DMTesneklik, DMTdurarak uzun atlama, DMTmekik, DMTdenge, DMTşınav, DMT6 dk koşu) ile belirlenirken, futbolcuların olgunluk düzeylerinin belirlenmesinde Biyo-gruplama kullanılmıştır. Çalışma sonucunda aynı kronolojik yaş gruplamasında farklı olgunluk seviyelerine sahip futbolcuların olduğu tespit edilmiştir. Sprint, yana atlama, esneklik, şınav değişkenlerinin biyo-gruplamaya göre gruplar arası karşılaştırılmasında fark saptanmamıştır. Denge, mekik, durarak atlama ve koşu değişkenlerinin biyo-gruplamaya göre gruplar arası karşılaştırılmasında anlamlı fark olduğu, mekik değişkeninde pubertal öncesi lehine, denge ve mekik, koşu ve durarak atlama değişkenlerinde pubertal lehine olduğu tespit edilmiştir. Sonuç olarak, biyo-gruplama yapılan futbolcularda aynı yaş grubu içerisinde farklı olgunlaşma seviyesine sahip futbolcuların olduğu, bu durumun motor beceri düzeylerini etkilediği tespit edilmiştir. Başta futbolcular olmak üzere bütün takım sporlarında sporcuların motor beceri düzeyleri tespit edilirken kronolojik yaşa ek olarak biyo-gruplamanın da kullanılması önerilmektedir.
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Rosida, Nur, Ani Mugiasih et Ahmad Muliadi. « Bio-intensive integrated control of tungro disease in the rice field ». E3S Web of Conferences 306 (2021) : 01050. http://dx.doi.org/10.1051/e3sconf/202130601050.
Texte intégralRésumé :
This research aims to gain the technology of bio-intensive integrated control of tungro. The experiments were done in a split-plot design with three replications. The main plot consisted of Bio-intensive integrated control, compared to Conventional control. The subplots are: 1) the susceptible varieties (TN1), 2) green leafhopper–resistant varieties (IR64), and 3) tungro resistant varieties (Inpari 9 Elo). The subplots are 10 m x 10 m, and every subplot is replicated three times. Variables observed were the population density of green leafhopper (GLH) and the predators, the percentage of tungro incidence, and the grain yield. The results showed that the population of GLH in the plots of bio-intensive integrated control (27.32, 2.34, 4.83, and 5.16) was lower than the population of GLH in conventional control (34.00, 21.17, 7.84, and 6.50). The GLH population density tends to be higher in varieties TN1 than the other varieties both in bio-intensive and conventional control. It is found that 12 species of predator exist in all varieties of bio-intensive control and conventional plots. At 8 WAT the infection of RTV on all varieties in bio-intensive plot control is lower (0.67 - 2.67%) than the incidence of tungro in conventional plot control (3.00 - 8.67%).
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Nuhriawangsa, A. M. P., D. Ardika, L. R. Kartikasari et B. S. Hertanto. « A study on physical characteristics of dried bio-slurry produced in tropical condition through treatment combination of drying and turning period ». IOP Conference Series : Earth and Environmental Science 902, no 1 (1 novembre 2021) : 012013. http://dx.doi.org/10.1088/1755-1315/902/1/012013.
Texte intégralRésumé :
Abstract The research aims to evaluate the physical characteristics of dried bio-slurry produced by treatment combination of drying and turning period in tropical conditions. Research material used fixed-dome digester model with a capacity of 12 m3 and cattle dung from Simmental crossbreed. Physical characteristics of bio-slurry were obtained by combining treatments between drying period (15 and 30 days) and turning period (each turning process in 7 and 10th day) as follows: T1 (15 days and 7th day), T2 (15 days and 10th day), T3 (30 days and 7th day), T4 (30 days and 10th day). The chemical compound of fresh bio-slurry was analyzed as initial information. The humidity, temperature, and color data were analyzed using analysis of variance and further analyzed using Tukey’s test. Also, the chemical compound and pH used descriptive analysis. The study obtained that the chemical composition of fresh bio-slurry was moisture content (89.53%), C-organic (37.27%), nitrogen (48.92ppm), phosphor (1.71%), potassium (3.89%), and C/N ratio (7.454). Besides, the treatment showed a significant difference (P<0.01) in humidity and color. Temperature dan pH of dried bio-slurry remained constant at 29.10-29.270C and 7 respectively. Therefore, treatment combinations can be applied to make dried bio-slurry as fertilizer in tropical conditions.
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Mohan, S. « BIO ANALYTIC AND ANALYTIC METHOD QUANTITATIVE TO TUCATINIB ESTIMATION IN PURE AND PHARMACEUTICAL DOSAGE FORM ». YMER Digital 21, no 08 (19 août 2022) : 782–92. http://dx.doi.org/10.37896/ymer21.08/65.
Texte intégralRésumé :
A simple one, accurate and precise method for estimating tucatinib in tablet dosage form was developed on symmetry C18 column (150x4.6mm, 3.5µ) using buffer and acetonitrile 40:60 pumped through a column with 1ml/min flow rate 0.1 percent formic acid of the buffer used in this method. The run time was 6 min in assay method and 12 min in bio analytical method. Reference standard and sample solutions were prepared by dissolving firstly in acetonitrile and diluted with diluents (mobile phase). Cisplatin was used as internal standard in bio analytical technique. These assay and bio analytical methods establish good linearity results (R2-0.999) with an optimized wavelength of 220nm. The technique was validated in assay method with respect to specificity, linearity, accuracy, robustness, LOD, LOQ, method precision, intermediate precision, degradation and in bio analytical method the technique was validated regarding specificity, linearity, recovery, matrix factor, precision, accuracy, and stability. Keywords: Tucatinib, HPLC, Development, LC-MS/MS, Rat plasma.
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Susanto, Dalhar, Mochamad Chalid, Widyarko, Intan Chairunnisa et Cut Sannas Saskia. « DRY RICE HUSK FILLER EFFECT TO TENSILE BEHAVIORS OF RECYCLED HIGH-DENSITY POLYETHYLENE (HDPE)-BASED GREEN COMPOSITES ». Journal of Southwest Jiaotong University 56, no 4 (30 août 2021) : 82–91. http://dx.doi.org/10.35741/issn.0258-2724.56.4.9.
Texte intégralRésumé :
The possibility of using plastic waste to manufacture hybrid bio-composite materials with the dry husk of Asian rice (Oryza sativa L.) is investigated. The most polluted and unsustainable plastic waste is High-Density Polyethylene (HDPE) due to its single-use, which decreases in quality if it is reused is selected. The mixtures chosen are local natural fiber and easy to find, potentially a preliminary study of a composites building material. Furthermore, to improve the tensile properties of this hybrid bio-composite material, an additional organic filler is used, such as rice husk (Oryza sativa L.) in a combination of 10%, 12%, and 15%. Samples for this study were processed using the hot press methods based on ASTM D882. Tested for tensile strength, modulus young, yield stress, and elongation is carried out to see an increase in the performance of the biocomposite material. The test results show that the best tensile properties are samples with 12% rice husk, resulting in excellent sample compatibility proofed by Scan Electron Microscopy to study bio-morphological composites. This project has shown that the composites based on natural fiber will be potential building materials due to their improved tensile properties.
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Susanto, Dalhar, Mochamad Chalid, Widyarko, Intan Chairunnisa et Cut Sannas Saskia. « DRY RICE HUSK FILLER EFFECT TO TENSILE BEHAVIORS OF RECYCLED HIGH-DENSITY POLYETHYLENE (HDPE)-BASED GREEN COMPOSITES ». Journal of Southwest Jiaotong University 56, no 4 (30 août 2021) : 82–91. http://dx.doi.org/10.35741/issn.0258-2724.56.4.9.
Texte intégralRésumé :
The possibility of using plastic waste to manufacture hybrid bio-composite materials with the dry husk of Asian rice (Oryza sativa L.) is investigated. The most polluted and unsustainable plastic waste is High-Density Polyethylene (HDPE) due to its single-use, which decreases in quality if it is reused is selected. The mixtures chosen are local natural fiber and easy to find, potentially a preliminary study of a composites building material. Furthermore, to improve the tensile properties of this hybrid bio-composite material, an additional organic filler is used, such as rice husk (Oryza sativa L.) in a combination of 10%, 12%, and 15%. Samples for this study were processed using the hot press methods based on ASTM D882. Tested for tensile strength, modulus young, yield stress, and elongation is carried out to see an increase in the performance of the biocomposite material. The test results show that the best tensile properties are samples with 12% rice husk, resulting in excellent sample compatibility proofed by Scan Electron Microscopy to study bio-morphological composites. This project has shown that the composites based on natural fiber will be potential building materials due to their improved tensile properties.
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Mahdianto, Choirul, Damayanti Buchori et Endang Sri Ratna. « Perilaku pemilihan pakan plastik dan respons biologi imago kumbang Tenebrio molitor L. (Coleoptera : Tenebrionidae) ». Jurnal Entomologi Indonesia 19, no 3 (15 décembre 2022) : 223–34. http://dx.doi.org/10.5994/jei.19.3.223.
Texte intégralRésumé :
The beetle Tenebrio molitor L. has potential as a plastic decomposer. Plastic can also be degraded by exposure to sunlight. The aim of this research was to determine the feeding behavior and biological responses of T. molitor exposed to various type of plastics. Seven types of plastics, namely bioplastics (Bio), expanded styrofoam (EPS), oxo-biodegradable (Oxo), three plastics Bio-P, EPS-P, Oxo-P that had been exposed to sunlight, and controls contained a mixed pollard-carrots slices were tested on four days-old of adult T. molitor. The choice feeding method was carried out at day and night by releasing 200 and 300 beetles in the middle of a ±15 cm diameter petri dish divided into 7 radial spaces, and their movement were observed within 24 hours. The forced feeding method for observing biological responses was carried out by releasing 10 male and female beetles in a petri dish as described above. The results showed that around 32–39% of the beetle population visited most of the pollard feed. In the feed treatment without pollard, 20% of the beetles chose EPS, EPS-P and Bio. Beetles survived 23 and 40 days on Bio and Bio-P feed, respectively. Egg production by the beetles exposed to the Bio and Bio-P diets was 2 and 3 eggs/female/10 days. Around 85% of pollard feed consumed contributed to 5% of body weight gain. About 58–64% of Bio, Bio-P, EPS, EPS-P and 6–12% Oxo, Oxo-P feeds were successfully consumed. The decrease in its body weight occurred in all plastic feed treatments ranging from 13–28%.
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Wang, Liuwei, Zhouyi Wang, Bingcheng Wang, Qingsong Yuan, Zhiyuan Weng et Zhendong Dai. « Reversible Adhesive Bio-Toe with Hierarchical Structure Inspired by Gecko ». Biomimetics 8, no 1 (16 janvier 2023) : 40. http://dx.doi.org/10.3390/biomimetics8010040.
Texte intégralRésumé :
The agile locomotion of adhesive animals is mainly attributed to their sophisticated hierarchical feet and reversible adhesion motility. Their structure–function relationship is an urgent issue to be solved to understand biologic adhesive systems and the design of bionic applications. In this study, the reversible adhesion/release behavior and structural properties of gecko toes were investigated, and a hierarchical adhesive bionic toe (bio-toe) consisting of an upper elastic actuator as the supporting/driving layer and lower bionic lamellae (bio-lamellae) as the adhesive layer was designed, which can adhere to and release from targets reversibly when driven by bi-directional pressure. A mathematical model of the nonlinear deformation and a finite element model of the adhesive contact of the bio-toe were developed. Meanwhile, combined with experimental tests, the effects of the structure and actuation on the adhesive behavior and mechanical properties of the bio-toe were investigated. The research found that (1) the bending curvature of the bio-toe, which is approximately linear with pressure, enables the bio-toe to adapt to a wide range of objects controllably; (2) the tabular bio-lamella could achieve a contact rate of 60% with a low squeeze contact of less than 0.5 N despite a ±10° tilt in contact posture; (3) the upward bending of the bio-toe under negative pressure provided sufficient rebounding force for a 100% success rate of release; (4) the ratio of shear adhesion force to preload of the bio-toe with tabular bio-lamellae reaches approximately 12, which is higher than that of most existing adhesion units and frictional gripping units. The bio-toe shows good adaptability, load capacity, and reversibility of adhesion when applied as the basic adhesive unit in a robot gripper and wall-climbing robot. Finally, the proposed reversible adhesive bio-toe with a hierarchical structure has great potential for application in space, defense, industry, and daily life.