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Articles de revues sur le sujet « Biliary epithelium »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Alpini, G., R. Lenzi, W. R. Zhai, et al. "Bile secretory function of intrahepatic biliary epithelium in the rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 1 (1989): G124—G133. http://dx.doi.org/10.1152/ajpgi.1989.257.1.g124.

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To shed light on ductular fluid secretion, hepatic histology and ultrastructure, cell proliferation and phenotypes, and several aspects of biliary physiology were studied in rats with ductular cell hyperplasia induced by either biliary obstruction (0-14 days) or 1-naphthylisothiocyanate (ANIT) feeding (0-28 days). In both groups of experimental animals, bile duct hyperplasia and spontaneous bile flow and secretin-induced choleresis increased with time of treatment in a linear fashion. Measurements of [14C]mannitol biliary entry and of biliary tree volume showed that the increase in both sponta

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2

Katabi, Nora. "Neoplasia of Gallbladder and Biliary Epithelium." Archives of Pathology & Laboratory Medicine 134, no. 11 (2010): 1621–27. http://dx.doi.org/10.5858/2009-0580-rar.1.

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Abstract Context.—Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients. Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. Objectives.—(1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differenti

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Nguyen, N. Thao T., Theresa R. Harring, Laurie Holley, John A. Goss, and Christine A. O’Mahony. "Biliary Adenofibroma with Carcinoma In Situ: A Rare Case Report." Case Reports in Hepatology 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/793963.

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This case report exhibits a rare biliary tumor within the liver of a 53-year-old Caucasian woman. This exophytic, multicystic, 6.5×5.0 cm mass was composed of complex tubulocystic structures lined by nonmucin-secreting, biliary epithelium embedded in fibrous stroma, consistent with biliary adenofibroma. This is the seventh case described in the literature. Multiple foci of high-grade dysplasia/carcinoma in situ were found with a microscopic focus of invasive carcinoma in review of the pathology, making this only the second case reporting malignant transformation. It is presented to illustrate

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Fava, Giammarco, Shannon Glaser, Heather Francis, and Gianfranco Alpini. "The Immunophysiology of Biliary Epithelium." Seminars in Liver Disease 25, no. 03 (2005): 251–64. http://dx.doi.org/10.1055/s-2005-916318.

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Park, Ji-Won, Jung-Hee Kim, Sung-Eun Kim, et al. "Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: Current Knowledge of Pathogenesis and Therapeutics." Biomedicines 10, no. 6 (2022): 1288. http://dx.doi.org/10.3390/biomedicines10061288.

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Cholangiopathies encompass various biliary diseases affecting the biliary epithelium, resulting in cholestasis, inflammation, fibrosis, and ultimately liver cirrhosis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the most important progressive cholangiopathies in adults. Much research has broadened the scope of disease biology to genetic risk, epigenetic changes, dysregulated mucosal immunity, altered biliary epithelial cell function, and dysbiosis, all of which interact and arise in the context of ill-defined environmental triggers. An in-depth understanding

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Li, Daneng, Ya-Han Zhang, Christiana J. Crook, and Renuka V. Iyer. "Updates in Biliary Tract Cancers." Cancers 14, no. 11 (2022): 2746. http://dx.doi.org/10.3390/cancers14112746.

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Allen, Steven R., Mubeen Jafri, Bryan Donnelly, et al. "Effect of Rotavirus Strain on the Murine Model of Biliary Atresia." Journal of Virology 81, no. 4 (2006): 1671–79. http://dx.doi.org/10.1128/jvi.02094-06.

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ABSTRACT Biliary atresia is a devastating disorder of the newborn in which afflicted infants develop inflammation and fibrosis of the extrahepatic biliary tract, resulting in cirrhosis and end-stage liver disease. Infection with a virus is thought to be a contributing factor in the etiology of biliary atresia. In the murine model of biliary atresia, perinatal exposure to rhesus rotavirus (RRV) results in biliary epithelial cell infection causing bile duct obstruction. The purpose of this study was to determine if tropism for the biliary epithelial cell was unique to RRV. Newborn mice underwent

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8

Terada, T., N. Kono, and Y. Nakanuma. "Immunohistochemical and immunoelectron microscopic analyses of alpha-amylase isozymes in human intrahepatic biliary epithelium and hepatocytes." Journal of Histochemistry & Cytochemistry 40, no. 11 (1992): 1627–35. http://dx.doi.org/10.1177/40.11.1431051.

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The expression and localization of the pancreatic and salivary isozymes of alpha-amylase in the intrahepatic biliary epithelium and hepatocytes were examined by the immunohistochemical method with polyclonal and monoclonal antibodies in 45 normal autopsied human livers. Immunoelectron microscopic studies with the protein A-gold method were performed with the monoclonal antibodies (MAb) on seven of the livers. The intrahepatic biliary system was divided into large ducts, septal ducts, interlobular ducts, bile ductules, and peribiliary glands. Immunohistochemically, pancreatic isozyme was observ

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Li, Feng, Yanli Zhang, Chunfu Li, et al. "Clonorchis sinensis infection induces pathological changes in feline bile duct epithelium and alters biliary microbiota composition." Parasite 31 (2024): 53. http://dx.doi.org/10.1051/parasite/2024053.

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Background: Clonorchis sinensis is a zoonotic liver fluke that inhabits the bile ducts of the human liver for prolonged periods, leading to cholangiocarcinoma. Recent research indicates associations between altered biliary microbiota and bile duct disorders. However, the impacts of C. sinensis infection on bile duct epithelium and subsequent effects on biliary microbiota remain unknown. Methods: Feline bile duct samples were collected from both uninfected and C. sinensis-infected cats. Histopathological examination was performed to assess epithelial changes, fibrosis, mucin and cell proliferat

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Glaser, Shannon. "Heterogeneity of the intrahepatic biliary epithelium." World Journal of Gastroenterology 12, no. 22 (2006): 3523. http://dx.doi.org/10.3748/wjg.v12.i22.3523.

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Strazzabosco, Mario, Carlo Spirlì, and Lajos Okolicsanyi. "Pathophysiology of the intrahepatic biliary epithelium." Journal of Gastroenterology and Hepatology 15, no. 3 (2000): 244–53. http://dx.doi.org/10.1046/j.1440-1746.2000.02091.x.

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Morell, Carola M., Luca Fabris, and Mario Strazzabosco. "Vascular biology of the biliary epithelium." Journal of Gastroenterology and Hepatology 28 (July 15, 2013): 26–32. http://dx.doi.org/10.1111/jgh.12022.

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13

Coad, R. A., J. R. Dutton, D. Tosh, and J. M. W. Slack. "Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness." Biochemistry and Cell Biology 87, no. 6 (2009): 975–87. http://dx.doi.org/10.1139/o09-063.

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The biliary system has a close developmental relationship with the pancreas, evidenced by the natural occurrence of small numbers of biliary-derived β-cells in the biliary system and by the replacement of biliary epithelium with pancreatic tissue in mice lacking the transcription factor Hes1. In normal pancreatic development, Hes1 is known to repress endocrine cell formation. Here we show that glucose-responsive insulin secretion can be induced in biliary epithelial cells when activity of the transcription factor Hes1 is antagonised. We describe a new culture system for adult murine gall bladd

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Seo, Dong Wan, Ho-Soon Choi, Sum P. Lee, and Rahul Kuver. "Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 6 (2004): G1247—G1256. http://dx.doi.org/10.1152/ajpgi.00013.2004.

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Oxysterols have been detected in various mammalian organs and blood. Biliary epithelium is exposed to high concentrations of cholesterol, and we have identified three keto-oxysterols (cholest-4-en-3-one, cholesta-4,6-dien-3-one, cholesta-3,5-dien-7-one) in human bile and gallstones. Because the effects of oxysterols on biliary physiology are not well defined, we investigated their biological effects on dog gallbladder epithelial cells. Enriched medium (culture medium containing taurocholate and lecithin and cholesterol ± various oxysterols) was applied to confluent monolayers of dog gallbladde

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15

Alshbib, Ayham, Krzysztof Grzyb, Trygve Syversveen, Henrik Mikael Reims, Kristoffer Lassen, and Sheraz Yaqub. "Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma." Case Reports in Surgery 2022 (February 7, 2022): 1–5. http://dx.doi.org/10.1155/2022/5280884.

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Biliary adenofibroma is a rare benign liver tumor with potential for malignant transition. It has a bile duct origin characterized by a complex tubulocystic biliary epithelium with fibrous stroma. MRI features may suggest this uncommon entity, and histological findings can be diagnostic. We report a case of biliary adenofibroma with transformation to an intrahepatic cholangiocarcinoma.

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I. Shaya, Khalida, Muna Zuhair, and Modhar S. Al-Omary. "Ultrastructural Changes In Human Gall Bladder Epithelium In Cholelithiasis." AL-QADISIYAH MEDICAL JOURNAL 8, no. 14 (2017): 98–110. http://dx.doi.org/10.28922/qmj.2012.8.14.98-110.

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Cholelithiasis is defined as the presence of stones within the lumen of the gall bladder or in the extrahepatic biliary tree. The goal of this study was to identify the ultrastructural ultrations of gall bladder epithelium in cholelithiesis. Gallbladder specimens were collected from patients who underwent cholectstectomy. Minute specimens were also fixed and processed to evaluate the fine structures of the gall bladder epithelium. The histological changes in semithin sections of methylene blue stain showed disruption of gall bladder epithelium and discontinuity of this epithelium with appearan

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Lui, Vincent Chi Hang. "Organoids in biliary atresia." World Journal of Pediatric Surgery 8, no. 2 (2025): e001010. https://doi.org/10.1136/wjps-2025-001010.

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Organoids are three-dimensional and self-organizing cell cultures of various lineages that resemble structures and functions of an organ in many ways, and they are versatile tools in disease modeling and patho-mechanistic study of human diseases affecting their tissues of origin. Biliary atresia (BA), a cholangiopathy affecting the bile ducts of the liver, is a heterogeneous and multifaceted liver disease of complex pathogenesis. Cholangiopathies refer to a category of liver diseases that affect the cholangiocytes, the epithelial cells lining the lumen of the biliary trees. Biliary organoids c

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Marucci, L., L. Ugili, G. Macarri, et al. "Primary biliary cirrhosis: modalities of injury and death in biliary epithelium." Digestive and Liver Disease 33, no. 7 (2001): 576–83. http://dx.doi.org/10.1016/s1590-8658(01)80110-9.

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19

Etherington, R. E., B. Millar, B. Innes, J. Brain, J. Kirby, and D. Jones. "T cell interactions with the biliary epithelium in primary biliary cholangitis." Journal of Hepatology 66, no. 1 (2017): S553—S554. http://dx.doi.org/10.1016/s0168-8278(17)31519-2.

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20

Dutta, Amal K., Al-karim Khimji, Meghana Sathe, et al. "Identification and functional characterization of the intermediate-conductance Ca2+-activated K+ channel (IK-1) in biliary epithelium." American Journal of Physiology-Gastrointestinal and Liver Physiology 297, no. 5 (2009): G1009—G1018. http://dx.doi.org/10.1152/ajpgi.00223.2009.

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In the liver, adenosine triphosphate (ATP) is an extracellular signaling molecule that is released into bile and stimulates a biliary epithelial cell secretory response via engagement of apical P2 receptors. The molecular identities of the ion channels involved in ATP-mediated secretory responses have not been fully identified. Intermediate-conductance Ca2+-activated K+ channels (IK) have been identified in biliary epithelium, but functional data are lacking. The aim of these studies therefore was to determine the location, function, and regulation of IK channels in biliary epithelial cells an

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21

Fabris, Luca, Carlo Spirli, Massimiliano Cadamuro, Romina Fiorotto, and Mario Strazzabosco. "Emerging concepts in biliary repair and fibrosis." American Journal of Physiology-Gastrointestinal and Liver Physiology 313, no. 2 (2017): G102—G116. http://dx.doi.org/10.1152/ajpgi.00452.2016.

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Chronic diseases of the biliary tree (cholangiopathies) represent one of the major unmet needs in clinical hepatology and a significant knowledge gap in liver pathophysiology. The common theme in cholangiopathies is that the target of the disease is the biliary tree. After damage to the biliary epithelium, inflammatory changes stimulate a reparative response with proliferation of cholangiocytes and restoration of the biliary architecture, owing to the reactivation of a variety of morphogenetic signals. Chronic damage and inflammation will ultimately result in pathological repair with generatio

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22

Rege, R. V., and E. W. Moore. "Convective movement of Ca2+ across guinea pig gallbladder epithelium." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 6 (1992): G990—G995. http://dx.doi.org/10.1152/ajpgi.1992.262.6.g990.

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Recently, much interest has developed in biliary calcium because of its importance in the pathogenesis and composition of gallstones. While much progress has been made in understanding the thermodynamic factors that control biliary calcium concentrations, little is known about the kinetic factors that control the movement of calcium across the gallbladder epithelium. These studies measure guinea pig gallbladder epithelial permeability to Ca2+ during in vivo convective water movement across the membrane. Water movement, ranging from -15.2 (absorption) to 6.3 microliters.min-1.cm-2 (water entry)

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Wasilewicz, Michał P., and Rafał Becht. "Intrahepatic Cholangiocarcinoma—Where Are We Now and Where Are We Going to?" Medicina 59, no. 4 (2023): 729. http://dx.doi.org/10.3390/medicina59040729.

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24

Chuang, Ya-Hui, Ruth Y. Lan, and M. Eric Gershwin. "The immunopathology of human biliary cell epithelium." Seminars in Immunopathology 31, no. 3 (2009): 323–31. http://dx.doi.org/10.1007/s00281-009-0172-5.

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Reynoso-Paz, Sandra, Ross L. Coppel, Ian R. Mackay, Nathan M. Bass, Aftab A. Ansari, and M. Eric Gershwin. "The immunobiology of bile and biliary epithelium." Hepatology 30, no. 2 (1999): 351–57. http://dx.doi.org/10.1002/hep.510300218.

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Kanno, Noriatsu, Gene LeSage, Shannon Glaser, Domenico Alvaro, and Gianfranco Alpini. "Functional heterogeneity of the intrahepatic biliary epithelium." Hepatology 31, no. 3 (2000): 555–61. http://dx.doi.org/10.1002/hep.510310302.

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Freeman, Hugh J., and WC Peter Kwan. "Occult Celiac Disease Associated with Lymphocytic Sclerosing Cholangitis." Canadian Journal of Gastroenterology 8, no. 4 (1994): 249–52. http://dx.doi.org/10.1155/1994/597238.

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A 60-year-old male with dermatitis herpetiformis and a previously treated lymphoma involving an inguinal lymph node developed abnormal liver chemistry tests. Because of intermittent diarrhea, additional studies revealed lymphocytic colitis and occult celiac disease that responded to a gluten-free diet. A liver biopsy done to explore persistently abnormal liver chemistry tests showed a portal tract-centred inflammatory process characterized by biliary ductal proliferation, epithelial lymphocytosis and concentric lamellar fibrosis. Quantitation of immunoglobulins was normal and antimitochondrial

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Nakanuma, Yasuni, Goroku Ohta, Naoko Kono, Kenichi Kobayashi, and Yasuhiro Kato. "Electron microscopic observation of destruction of biliary epithelium in primary biliary cirrhosis." Liver 3, no. 4 (2008): 238–48. http://dx.doi.org/10.1111/j.1600-0676.1983.tb00874.x.

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Hayward, A. R., J. Levy, F. Facchetti, et al. "Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM." Journal of Immunology 158, no. 2 (1997): 977–83. http://dx.doi.org/10.4049/jimmunol.158.2.977.

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Abstract We report an association between X-linked immunodeficiency with hyper-IgM (XHIM) and carcinomas affecting the liver, pancreas, biliary tree, and associated neuroectodermal endocrine cells. The tumors were fatal in eight of nine cases and in most instances were preceded by chronic cholangiopathy and/or cirrhosis. An additional group of subjects with XHIM had chronic inflammation of the liver or bile ducts but no malignancy. Many patients with XHIM were infected with cryptosporidia. CD40 is normally expressed on regenerating or inflammed bile duct epithelium. A CD40+ hepatocellular carc

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Vijayan, V., and CEL Tan. "A computer-generated three-dimensional view of the developing human biliary system." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 626–27. http://dx.doi.org/10.1017/s0424820100165598.

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With the advent of computers, microscopy has entered an exciting new era of computerised three dimensional (3D) reconstruction. Using serial sections, it is now possible to generate complex 3D images, that can be rotated at various angles to study the organ systems of interest. In this project, the first of its kind, we have used computer generated 3D reconstruction to study the developing human biliary system.The human biliary system consists of the extra and intrahepatic components. The extrahepatic system develops from the embryonic hepatic diverticulum and is tubular from the start. The in

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Perrone, R. D., S. A. Grubman, L. C. Rogers, et al. "Continuous epithelial cell lines from ADPKD liver cysts exhibit characteristics of intrahepatic biliary epithelium." American Journal of Physiology-Gastrointestinal and Liver Physiology 269, no. 3 (1995): G335—G345. http://dx.doi.org/10.1152/ajpgi.1995.269.3.g335.

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We have produced continuous cell lines using retroviral transduction of SV40 large T antigen into epithelial cells removed from the lumen of liver cysts from four female patients with autosomal dominant polycystic kidney disease (ADPKD). Liver cyst-derived epithelial (LCDE) cell lines are grown in a hormonally supplemented medium in the presence of lethally irradiated NIH/3T3 fibroblast coculture. LCDE cells maintain their epithelial appearance and are positive for the biliary-specific markers cytokeratin 7 and 19 and gamma-glutamyl transpeptidase while being negative for hepatocyte markers. S

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Wilkie, J. S. Nimmo, J. A. Yager, P. N. Nation, E. G. Clark, H. G. G. Townsend, and J. D. Baird. "Chronic Eosinophilic Dermatitis: A Manifestation of a Multisystemic, Eosinophilic, Epitheliotropic Disease in Five Horses." Veterinary Pathology 22, no. 4 (1985): 297–305. http://dx.doi.org/10.1177/030098588502200401.

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A generalized, chronic, progressive, exfoliative dermatitis in five horses is described. Histologically, the lesion is characterized by a superficial and deep perivascular dermatitis which is eosinophil-rich with a marked lymphocytic and plasmacytic component, accompanied by marked acanthosis and hyperkeratosis. More severe cases progress to a lichenoid pattern with the same cellular composition with focal eosinophilic spongiosis and eosinophilic subcorneal pustules. Clinically, the disease is associated with chronic, severe weight loss and is fulminating. The skin lesions are accompanied by l

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Harada, Kenichi, Yasunori Sato, Hiroko Ikeda, Maylee Hsu, Saya Igarashi, and Yasuni Nakanuma. "Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours." Journal of Clinical Pathology 66, no. 5 (2013): 386–91. http://dx.doi.org/10.1136/jclinpath-2012-201273.

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AimsBiliary neuroendocrine tumours (NETs) are rare and mostly exist as a component of mixed adenoneuroendocrine carcinomas (MANECs). Although the NET component in biliary MANECs is generally more malignant and clinically more important to the prognosis than the ordinary adenocarcinomatous component, the histogenesis of biliary NET has not been clarified. In this study, the role of the Notch1-Hes1 signalling axis in the histogenesis of biliary NETs was examined.MethodsImmunohistochemistry for Notch1, its ligand Jagged1 and Hes1 was performed using surgical specimens from 11 patients with biliar

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Fabris, L., M. Cadamuro, C. Spirlì, et al. "Evidence for epithelial–mesenchymal transition in the biliary epithelium of human cholangiocarcinoma." Digestive and Liver Disease 40, no. 5 (2008): A10—A11. http://dx.doi.org/10.1016/j.dld.2007.12.041.

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Rocha, Eduardo, Rogério A. F. Monteiro, and Carlos A. Pereira. "Presence of rodlet cells in the intrahepatic biliary ducts of the brown trout, Salmo trutta fario Linnaeus, 1758 (Teleostei, Salmonidae)." Canadian Journal of Zoology 72, no. 9 (1994): 1683–87. http://dx.doi.org/10.1139/z94-225.

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We report for the first time rodlet cells in the epithelium of intrahepatic biliary ducts of the brown trout (Salmo trutta fario Linnaeus 1758). Such cells have not been described in the liver of any salmonid. Several developmental stages of the rodlet cells were found, including mature, discharging elements. The number of rodlet cells decreased from June to April. Intra-epithelial macrophages were found in close proximity to rodlet cells, suggesting a mild pathological reaction.

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Kwon, Dong Hyang, Lynt B. Johnson, and Metin Ozdemirli. "Primary Epidermoid Cyst of Biliary Duct Presenting as Choledochal Cyst." International Journal of Surgical Pathology 25, no. 7 (2017): 619–22. http://dx.doi.org/10.1177/1066896917710717.

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Choledochal cyst is a cystic dilation of the biliary tree that can increase the risk of malignancy in bile ducts and the gallbladder. These are usually lined by bile duct epithelium, which may undergo intestinal and squamous metaplasia. This is the first report of clinically diagnosed type II choledochal cyst that is entirely lined by metaplastic stratified squamous epithelium, unlike most other cysts, which are histologically lined by bile duct epithelium. This observation can potentially explain the underlying pathogenic mechanism of rare reports of squamous cell carcinomas arising in bile d

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Benson, Katherine K., Ankur Sheel, Shafia Rahman, Ashwini Esnakula, and Ashish Manne. "Understanding the Clinical Significance of MUC5AC in Biliary Tract Cancers." Cancers 15, no. 2 (2023): 433. http://dx.doi.org/10.3390/cancers15020433.

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Biliary tract cancers (BTC) arise from biliary epithelium and include cholangiocarcinomas or CCA (including intrahepatic (ICC) and extrahepatic (ECC)) and gallbladder cancers (GBC). They often have poor outcomes owing to limited treatment options, advanced presentations, frequent recurrence, and poor response to available systemic therapy. Mucin 5AC (MUC5AC) is rarely expressed in normal biliary epithelium, but can be upregulated in tissues of benign biliary disease, premalignant conditions (e.g., biliary intraepithelial neoplasia), and BTCs. This mucin’s numerous glycoforms can be divided int

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Hansel, Donna E., Anirban Maitra, John W. Lin, et al. "Expression of the Caudal-Type Homeodomain Transcription Factors CDX 1/2 and Outcome in Carcinomas of the Ampulla of Vater." Journal of Clinical Oncology 23, no. 9 (2005): 1811–18. http://dx.doi.org/10.1200/jco.2005.03.068.

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Purpose Adenocarcinomas of the ampulla of Vater demonstrate a characteristic histology but vary significantly in outcome. As a consequence, prognostic factors for these cancers are poorly defined. The caudal-type homeodomain transcription factors 1 (CDX1) and 2 (CDX2) regulate axial development and intestinal differentiation. We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome. Patients and Methods Fifty-three resected carcinomas of the ampulla of Vater, 31 pancreatic ductal adenocarcinomas, and 15 extrahepati

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Firrincieli, Delphine, Silvia Zuniga, Raoul Poupon, Chantal Housset, and Nicolas Chignard. "Role of Nuclear Receptors in the Biliary Epithelium." Digestive Diseases 29, no. 1 (2011): 52–57. http://dx.doi.org/10.1159/000324129.

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Vij, Mukul, and Mohamed Rela. "Biliary atresia: pathology, etiology and pathogenesis." Future Science OA 6, no. 5 (2020): FSO466. http://dx.doi.org/10.2144/fsoa-2019-0153.

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Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice. Histopathological findings in liver biopsies include the expansion of the portal tracts, with edematous fibroplasia and bile ductular proliferation, with bile plugs in duct lumen. Lobular morphological features may include variable multinucleate giant cells, bilirubinostasis and hemopoiesis. The etiopathogenesis of biliary atresia is multifactorial and multiple pathomechanisms have been proposed. Experimental and

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Zoltowska, Monika, Edgard E. Delvin, Khazal Paradis, Ernest Seidman, and Emile Levy. "Bile duct cells: a novel in vitro model for the study of lipid metabolism and bile acid production." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 2 (1999): G407—G414. http://dx.doi.org/10.1152/ajpgi.1999.276.2.g407.

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Immortalized bile duct cells (BDC), derived from transgenic mice harboring the SV40 thermosensitive immortalizing mutant gene ts458, were utilized to investigate the role of the biliary epithelium in lipid and sterol metabolism. This cell model closely resembles the in vivo situation because it expresses the specific phenotypic marker cytokeratin 19 (CK-19), exhibits the formation of bile duct-like structures, and displays well-formed microvilli projected from the apical side to central lumen. The BDC were found to incorporate [14C]oleic acid (in nmol/mg protein) into triglycerides (121 ± 6),

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Treem, W. R., G. A. Krzymowski, R. W. Cartun, C. A. Pedersen, J. S. Hyams, and M. Berman. "Cytokeratin Immunohistochemical Examination of Liver Biopsies in Infants with Alagille Syndrome and Biliary Atresia." Journal of Pediatric Gastroenterology and Nutrition 15, no. 1 (1992): 73–80. http://dx.doi.org/10.1002/j.1536-4801.1992.tb10604.x.

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SummaryIdentifying bile duct epithelium is sometimes difficult with standard histologie techniques. The availability of antibodies to specific cy tokeratin (CK) intermediate filaments has allowed identification of CK expressed by bile duct epithelium. Formalin‐fixed, paraffin‐embedded liver tissue from five infants (aged 1–12 months) with Alagille syndrome and five infants with biliary atresia (aged 1.5–11 months) were pepsin digested then reacted with a combination of anti‐cytokeratin monoclonal antibodies using an avidin‐biotin immunoper‐oxidase technique. Liver tissue obtained at autopsy fr

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Merlen, Grégory, Nicolas Kahale, Jose Ursic-Bedoya, et al. "TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function." Gut 69, no. 1 (2019): 146–57. http://dx.doi.org/10.1136/gutjnl-2018-316975.

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ObjectiveWe explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability.DesignExperiments were performed under basal and TGR5 agonist treatment. In vitro transepithelial electric resistance (TER) and FITC-dextran diffusion were measured in different cell lines. In vivo FITC-dextran was injected in the gallbladder (GB) lumen and traced in plasma. Tight junction proteins and TGR5-induced signalling were investigated in vitro and in vi

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Bründler, Marie-Anne, Norberto Rodriguez-Baez, Ron Jaffe, Arthur G. Weinberg, and Beverly Barton Rogers. "Adenovirus Ascending Cholangiohepatitis." Pediatric and Developmental Pathology 6, no. 2 (2003): 156–59. http://dx.doi.org/10.1007/s10024-002-0063-4.

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Three children, two with liver transplants and one with acquired human immunodeficiency virus (HIV) infection, presented with hepatitis accompanied by elevated gamma glutamyl transpeptidase. Biopsies revealed cholangiohepatitis caused by adenovirus infection. There was a progressive loss of interlobular bile ducts in two of the patients. In one patient, infection of the biliary tree was marked by a necrotizing cholangitis, with adenoviral inclusions noted in the biliary epithelium. In each patient, there was evidence of adenovirus gastrointestinal infection. This is the first report of adenovi

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Bajaj, Anubha. "The Muculent Bleb-Mucinous Cystic Neoplasm-Hepatobiliary Region." Cell & Cellular Life Sciences Journal 9, no. 1 (2024): 1–3. http://dx.doi.org/10.23880/cclsj-16000201.

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Mucinous cystic neoplasm configures as a cystic neoplasm incriminating the hepatic parenchyma. Tumour is constituted of multi-locular or cystic cavity layered with mucinous or biliary type epithelium encompassed within an ovarian type stroma. The cystic lesion appears non communicative with adjoining bile ducts. Additionally designated as hepatobiliary cystadenoma, biliary cystadenoma or cystadenoma with mesenchymal stroma, neoplasms associated with invasive carcinoma component may be denominated as hepatobiliary cystadenocarcinoma.

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Boyer, J. L. "Bile duct epithelium: frontiers in transport physiology." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 1 (1996): G1—G5. http://dx.doi.org/10.1152/ajpgi.1996.270.1.g1.

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The bile duct epithelium is known to modify hepatic bile by both secretory and absorptive processes. However, identification and characterization of the transport systems that carry out these physiological functions at the cellular and molecular level have been slow compared with progress in understanding hepatic bile production. Recently, techniques have been developed that enable bile duct cells to be isolated in substantial number and purity and as intact polarized units that can be studied in vitro. These newer preparations have enabled classic physiological approaches to be performed dire

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Aneiros Castro, Belén, Indalecio Cano Novillo, Araceli García Vázquez, and Mónica De Miguel Moya. "Association between gallbladder agenesis and choledochal cyst: cause or coincidence?" BMJ Case Reports 12, no. 6 (2019): e229986. http://dx.doi.org/10.1136/bcr-2019-229986.

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This case report describes an extremely rare association between gallbladder agenesis and choledochal cyst (CC). A 9-year-old girl presented with recurrent abdominal pain in the right upper quadrant. Radiological studies revealed a CC type IVa and an agenesis of gallbladder and cystic duct. Due to the possibility of biliary neoplasm, the patient underwent cyst resection and hepaticoduodenostomy. Histopathological findings showed inflamed fibrous tissue covered by biliary epithelium with no evidence of malignancy.

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Fabris, Luca, Carlo Spirli, and Joachim Mertens. "Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment." International Journal of Molecular Sciences 20, no. 16 (2019): 3961. http://dx.doi.org/10.3390/ijms20163961.

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In modern hepatology, diseases of the biliary epithelium, currently termed cholangiopathies, represent one of the main gaps in knowledge, both on experimental and clinical grounds, though they started to draw attention since the late 80s [...]

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Dubey, J. P., Kimberley J. Evason, and Zenta Walther. "Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans." Parasitology 146, no. 07 (2019): 865–72. http://dx.doi.org/10.1017/s003118201900012x.

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AbstractCystoisospora(Isospora)belliis a coccidian parasite of humans. It can cause serious digestive disorders involving infection of intestines, biliary tract and gallbladder, especially in those with depressed immunity. It has a direct fecal–oral transmission cycle. After ingestion of sporulated oocysts, the parasite multiplies asexually and sexually within host epithelial cells, resulting in unsporulated oocysts that are excreted in feces. The details of asexual and sexual stages are not known and certain inclusions in epithelial cells in biopsy samples have been erroneously identified rec

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Alvaro, Domenico, Gianfranco Alpini, Paolo Onori, et al. "Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats." Gastroenterology 119, no. 6 (2000): 1681–91. http://dx.doi.org/10.1053/gast.2000.20184.

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