Articles de revues : « Beta sultam »

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Tyas, Retno Muktining, et Joko Kuncoro. « HUBUNGAN ANTARA KONFORMITAS TEMAN SEBAYA DENGAN PERILAKU DUGEM PADA MAHASISWA UNIVERSITAS ISLAM SULTAN AGUNG SEMARANG ». Proyeksi 13, n^o 1 (26 septembre 2020) : 57. http://dx.doi.org/10.30659/jp.13.1.57-67.

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Tujuan dari penelitian ini adalah untuk menemukan hubungan antara konformitas teman sebaya dengan perilaku dugem pada Mahasiswa Universitas Islam Sultan Agung Semarang. Metode dari penelitian ini adalah kuantitatif. Penelitian ini melibatkan 70 subjek yang dipilih menggunakan metode kuota purposive random sampling. Pengambilan data dilakukan dengan memberikan skala konformitas dan skala perilaku dugem. Skala konformitas terdiri dari 30 aitem dengan rentang daya beda tinggi 0,250 � 0,533 dan koefisien reliabilitas sebesar 0,817. Skala perilaku dugem berjumlah 40 aitem dengan rentang daya beda 0,300 � 0,810 dan koefisien reliabilitas sebesar 0,971. Hasil uji hipotesis koefisien korelasi diperoleh rxy = 0,713 dengan taraf signifikansi p= 0,000 (p<0,01). Hasil tersebut menunjukkan bahwa hipotesis diterima. Artinya ada hubungan positif antara konformitas teman sebaya dengan perilaku dugem pada Mahasiswa Universitas Islam Sultan Agung Semarang.

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Almeman, Ahmad Abdulrahman, Yasir Ahmed Beshir et Ahmad Hamad Aldosary. « Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients ». Current Drug Safety 14, n^o 1 (17 janvier 2019) : 27–30. http://dx.doi.org/10.2174/1574886313666181029101247.

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Background: Cardioselective beta-blockers may affect glucose or lipid profiles. Objective: We sought to compare the effects of two beta-blockers, metoprolol and bisoprolol, as the most commonly used drugs in cardiology, on glucose and lipid profiles in patients with cardiovascular diseases. Methods: We conducted a retrospective cross-sectional matched study at Prince Sultan Cardiac Center in Burydah in August 2017. Patient records were screened, and adult patients with cardiovascular disorders who were treated with a stable dose of metoprolol or bisoprolol were included. Parameters related to glucose and lipid metabolism were compared using the Student’s t-test between the two groups. Results and Conclusion: The metoprolol and bisoprolol arms included 204 and 200 patients, respectively.

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Winahyu, Diah Astika, Ade Maria Ulfa et Risqi Indri Lestari. « PENETAPATAN KADAR BETA KAROTEN PADA KULIT BUAH NAGA MERAH DAN KULIT BUAH NAGA PUTIH DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS ». Jurnal Analis Farmasi 6, n^o 1 (15 novembre 2021) : 25–29. http://dx.doi.org/10.33024/jaf.v6i1.5486.

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Buah naga merah terkenal sebagai salah satu sumber beta karoten yang sangat berguna sebagai pengganti antioksidan, meningkatkan sistem imun dan mengobati berbagai penyakit. Penelitian ini bertujuan untuk mengetahuikadar beta karoten pada kulit buah naga merah dan kulit buah naga putih dengan menggunakan metode spektrofotometri UV-Vis. Ekstraksi senyawa beta karoten dari kulit buah naga dilakukan dengan menggunakan petroleum eter kemudian di sentrifuge selama 5 menit. Setelah itu ditambahkan natrium sulfat anhidrat dan dibekukan selama 24 jam.Setelah dilakukan analisis senyawa beta karoten dengan menggunakan spektrofotometri UV-Vis. Hasil dari penelitian menunjukkan bahwa ekstrak kulit buah naga mengandung senyawa beta karoten. Berdasarkan hasil analisis spektrofotometri UV-Vis, pada panjang gelombang maksimum sebesar 451 nm, kulit buah naga merah memiliki kadar rata-rata beta karoten sebesar 0,015%dan kulit buah naga putih memiliki kadar rata-rata beta karoten sebesar 0,027%. Hasil ini sesuai dengan Ha dimana kadar beta karoten pada kulit buah naga merah lebih besar daripada kulit buah naga putih.Kata kunci :kulit buah naga, beta karoten, spektrofotometri UV-Vis

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Sari, Heni Ratna, et Ruseno Arjanggi. « PERAN EFIKASI DIRI DAN DUKUNGAN SOSIAL TEMAN SEBAYA TERHADAP BELAJAR BERDASAR REGULASI DIRI PADA MAHASISWA UNIVERSITAS ISLAM SULTAN AGUNG SEMARANG ». Proyeksi 14, n^o 1 (11 août 2020) : 53. http://dx.doi.org/10.30659/jp.14.1.53-62.

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Penelitian ini bertujuan untuk mengetahui peran efikasi diri dan dukungan sosial teman sebaya terhadap belajar berdasar regulasi diri pada mahasiswa Universitas Islam Sultan Agung Semarang. Penelitian ini menggunakan metode kuantitatif korelasional. Populasi dalam penelitian ini adalah mahasiswa Universitas Islam Sultan Agung Semarang. Sampel penelitian ini berjumlah� 150 mahasiswa Universitas Islam Sultan Agung Semarang. Metode pengambilan sampel menggunakan simple random sampling. Alat ukur yang digunakan dalam penelitian ini terdiri dari tiga skala. Skala belajar berdasar regulasi diri berjumlah 68 aitem yang memiliki koefisien reliabilitas 0,941 dengan indeks daya beda aitem bergerak antara 0,277 sampai 0,683. Skala efikasi diri berisi 30 aitem yang memiliki koefisien� reliabilitas 0,896 dengan indeks daya beda aitem yang bergerak antara 0,256 sampai 0,693. Serta skala dukungan sosial teman sebaya berisi 40 aitem yang memiliki koefisien reliabilitas 0,919 dengan indeks daya beda aitem yang bergerak antara 0,301 sampai 0,726. Analisis data menggunakan analisis regresi ganda dan parsial. Hasil penelitian menunjukskan adanya peran positif efikasi diri dan dukungan sosial teman sebaya terhadap belajar berdasar regulasi diri dengan diperoleh skor R= 0,325 dan Fhitung= 8,665, p= 0,000 (p<0,05). Variabel efikasi diri dan dukungan sosial teman sebaya secara bersamaan memiliki sumbangan efektif sebesar 10,5% terhadap variabel belajar berdasar regulasi diri. Uji korelasi parsial efikasi diri dengan belajar berdasar regulasi diri diperoleh skor rx1y= 0,178 dengan signifikan 0,030 (p<0,05). Hasil tersebut menunjukkan adanya peran positif efikasi diri terhadap belajar berdasar regulasi diri. Uji korelasi parsial dukungan sosial teman sebaya dengan belajar berdasar regulasi diri diperoleh skor rx2y= 0,173 dengan signifikan 0,035 (p<0,05). Hasil tersebut menunjukkan adanya peran positif dukungan sosial teman sebaya terhadap belajar berdasar regulasi diri.

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Uchiyama, H., BA Barut, AF Mohrbacher, D. Chauhan et KC Anderson. « Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion ». Blood 82, n^o 12 (15 décembre 1993) : 3712–20. http://dx.doi.org/10.1182/blood.v82.12.3712.3712.

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Abstract Previous studies show that human myeloma-derived cell lines specifically adhere to fibronectin (FN) through very late antigen-4 (VLA-4; alpha 4 beta 1 integrin complex) and RGD-peptide mechanisms, which may contribute to the localization of tumor cells in bone marrow (BM). In these studies, we characterized the adhesion of myeloma- derived cell lines to both normal and myeloma BM stromal cells (BMSCs) and the effect of adhesion on DNA synthesis. Because interleukin-6 (IL- 6) plays an important role in the pathogenesis of multiple myeloma, we also examined the effects of tumor cell adhesion on IL-6 secretion by BMSCs. In 51chromium binding assays, the U266, ARH-77, and IM-9 cell lines showed 52% +/- 12%, 55% +/- 6%, and 47% +/- 7% specific adherence, respectively, to normal BMSCs and 74% +/- 4%, 60% +/- 3%, and 61% +/- 6% specific adherence, respectively, to myeloma BMSCs. In contrast, only 12% to 13% specific binding of HS-Sultan cells to BMSCs was noted. The binding of myeloma cells to BMSCs was partially blocked with anti-beta 1 monoclonal antibody (MoAb), anti-beta 2 integrin MoAb, and excess RGD peptide, suggesting multiple mechanisms for the adhesion of myeloma cell lines to BMSCs. Binding of cell lines to FN or myeloma BMSCs did not affect cell line proliferation; however, adhesion of myeloma cell lines to normal BMSCs decreased DNA synthesis, ie, stimulation indices are 0.1 +/- 0.04, 0.2 +/- 0.1, 0.2 +/- 0.07, and 0.1 +/- 0.06 for the adherent non-IL-6-dependent U266, ARH-77, HS- Sultan, and IM-9 cells, respectively (n = 5, P < .01). In contrast, adherence of IL-6-dependent B9 cells increased their proliferation (stimulation index, 3.2 +/- 0.7). Significant (twofold to eightfold) increases in IL-6 secretion were evident in cell line-adherent (> or = 12 hours) normal and myeloma BMSC cultures. Paraformaldehyde fixation of BMSCs before adhesion completely abrogated IL-6 secretion, suggesting that IL-6 secretion was triggered in BMSCs rather than in cell lines. Partial blocking of cell line adhesion to BMSCs, using anti- beta 1 integrin and anti-beta 2 integrin MoAbs and RGD peptide, also partially blocked the triggering of IL-6 secretion by BMSCs. When cell lines were placed in Transwell inserts and then cultured with either normal or myeloma BMSCs, permitting juxtaposition without cell to cell contact between myeloma cell lines and BMSCs, no increase in IL-6 secretion was observed.(ABSTRACT TRUNCATED AT 400 WORDS)

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Uchiyama, H., BA Barut, AF Mohrbacher, D. Chauhan et KC Anderson. « Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion ». Blood 82, n^o 12 (15 décembre 1993) : 3712–20. http://dx.doi.org/10.1182/blood.v82.12.3712.bloodjournal82123712.

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Previous studies show that human myeloma-derived cell lines specifically adhere to fibronectin (FN) through very late antigen-4 (VLA-4; alpha 4 beta 1 integrin complex) and RGD-peptide mechanisms, which may contribute to the localization of tumor cells in bone marrow (BM). In these studies, we characterized the adhesion of myeloma- derived cell lines to both normal and myeloma BM stromal cells (BMSCs) and the effect of adhesion on DNA synthesis. Because interleukin-6 (IL- 6) plays an important role in the pathogenesis of multiple myeloma, we also examined the effects of tumor cell adhesion on IL-6 secretion by BMSCs. In 51chromium binding assays, the U266, ARH-77, and IM-9 cell lines showed 52% +/- 12%, 55% +/- 6%, and 47% +/- 7% specific adherence, respectively, to normal BMSCs and 74% +/- 4%, 60% +/- 3%, and 61% +/- 6% specific adherence, respectively, to myeloma BMSCs. In contrast, only 12% to 13% specific binding of HS-Sultan cells to BMSCs was noted. The binding of myeloma cells to BMSCs was partially blocked with anti-beta 1 monoclonal antibody (MoAb), anti-beta 2 integrin MoAb, and excess RGD peptide, suggesting multiple mechanisms for the adhesion of myeloma cell lines to BMSCs. Binding of cell lines to FN or myeloma BMSCs did not affect cell line proliferation; however, adhesion of myeloma cell lines to normal BMSCs decreased DNA synthesis, ie, stimulation indices are 0.1 +/- 0.04, 0.2 +/- 0.1, 0.2 +/- 0.07, and 0.1 +/- 0.06 for the adherent non-IL-6-dependent U266, ARH-77, HS- Sultan, and IM-9 cells, respectively (n = 5, P < .01). In contrast, adherence of IL-6-dependent B9 cells increased their proliferation (stimulation index, 3.2 +/- 0.7). Significant (twofold to eightfold) increases in IL-6 secretion were evident in cell line-adherent (> or = 12 hours) normal and myeloma BMSC cultures. Paraformaldehyde fixation of BMSCs before adhesion completely abrogated IL-6 secretion, suggesting that IL-6 secretion was triggered in BMSCs rather than in cell lines. Partial blocking of cell line adhesion to BMSCs, using anti- beta 1 integrin and anti-beta 2 integrin MoAbs and RGD peptide, also partially blocked the triggering of IL-6 secretion by BMSCs. When cell lines were placed in Transwell inserts and then cultured with either normal or myeloma BMSCs, permitting juxtaposition without cell to cell contact between myeloma cell lines and BMSCs, no increase in IL-6 secretion was observed.(ABSTRACT TRUNCATED AT 400 WORDS)

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Neli Awat Hi M Nur et Djoko Widagdo. « Pengaruh Kualitas Pelayanan Terminal Kargo Terhadap Kepuasan Pengguna Jasa di Bandar Udara Sultan Babullah Ternate ». Jurnal Multidisiplin Madani 2, n^o 4 (29 avril 2022) : 1739–52. http://dx.doi.org/10.55927/mudima.v2i4.292.

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The growth in the number of passengers continues to increase every year, this is also followed by an increase in the number of postal and cargo transportation using airplanes, the purpose of this study is to find out how much influence the quality of cargo terminal services has on service user satisfaction at the airport of Sultan Babullah Ternate, service quality is the success of an achievement of a company in creating positive thinking from customers can also make customers feel satisfied. The method in this research uses quantitative methods or data collection is obtained from primary data with the questionnaire method. The population in this study are users of cargo terminal services in Sultan Babullah Airport Ternate, in this study requires a sample of 100 respondents. the sample or data source is selected using Non-Probability Sampling with Incidental Sampling Technique. The results in this study have an effect on the quality of cargo terminal services on service user satisfaction at Sultan Babullah Airport, Ternate. Showing the output results obtained from the beta coefficient value is 0.983 with t count that is 53.628 and t table is 1.98447 because t count > t table then Ho is rejected and Ha is accepted. In conclusion, the variable (X) of service quality has an influence on the variable (Y) of service user satisfaction with an effect of 0.983 or 98.3%.

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Kharisma, Oktaf Brillian, et Reski Riandi. « IMPLEMENTASI APLIKASI SISTEM PENYUSUNAN JADWAL KULIAH PADA JURUSAN TEKNIK ELEKTRO UIN SULTAN SYARIF KASIM ». Jurnal Teknologi Informasi Jurnal Keilmuan dan Aplikasi Bidang Teknik Informatika 12, n^o 2 (1 août 2018) : 59–68. http://dx.doi.org/10.47111/jti.v12i2.533.

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Proses penyusunan jadwal perkuliahan merupakan kegiatan rutin setiap universitasdalam menghadapi setiap semester baru. Jurusan Teknik Elektro UIN Suska Riau,penyusunan jadwal perkuliahan masih menggunakan program Microsoft Excel. Sehingga,pembuatan jadwal tersebut masih kurang efisien karena prosesnya membutuhkan waktuyang lama dan harus melakukan revisi jadwal yang bentrok. Maka,dibutuhkan sebuah sistemyang dapat menangani proses penjadwalan perkuliahan tersebut dengan menerapkan metodeasosiasi berbasis web. Denagan adanya aplikasi ini nantinya proses perkuliahan di jurusanteknik elektro dapat dapat dilakukan tanpa adanya jadwal perkuliahan yang bentrok danproses penyusunannya dapat dilakukan dengan cepat. Aplikasi yang dibangun akanmengenerate otomatis dan menampilkan jadwal berupa tabel penjadwalan secarakeseluruhan yaitu berupa data dosen, data waktu, data mata kuliah, dan data ruangan. Darihasil uji beta yang dilakukan oleh 100 dosen sebagai subjek penguji menyatakan bahwakeberhasilan system sebesar 75%.

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Nuzula, Nike Ika, Wiwit Sri Werdi Pratiwi, Novi Indriyawati et Makhfud Efendy. « STUDI PENGGUNAAN SENYAWA CaCl2 DALAM MENURUNKAN KADAR SULFAT PADA LIMBAH PRODUKSI GARAM ». Jurnal Kimia Riset 6, n^o 1 (28 juin 2021) : 20. http://dx.doi.org/10.20473/jkr.v6i1.23159.

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Bittern adalah salah satu hasil dari proses produksi garam yang saat ini pemanfaatannya belum maksimal. Hal ini dikarenakan banyaknya pengotor yang terkadung didalamnya. Sulfat merupakan pengotor tertinggi kedua dalam bittern. Penelitian ini dilakukan untuk mengikat sulfat pada bittern dengan menggunakan CaCl₂.2H₂O dengan metode penambahan yang berbeda-beda. Variasi yang digunakan dalam penelitian ini adalah perbandingan mol antara bittern dengan Kristal CaCl2. Perbandingan mol terbaik antara bittern dengan Kristal CaCl2 didapatkan rasio sebesar 1: 0.9 dengan kadar sulfat sebesar 4.83 mg/L, dimana kadar awal sulfat pada sampel bittern sebesar 41.257 g/L atau setara dengan 41257 mg/L..

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Guswanto, Imam, et Inhastuti Sugiasih. « HUBUNGAN RASA MEMILIKI DAN KOMITMEN DENGAN MOTIVASI BERPRESTASI PEMAIN FUTSAL FAKULTAS DI UNIVERSITAS ISLAM SULTAN AGUNG SEMARANG ». Proyeksi 13, n^o 2 (26 septembre 2020) : 144. http://dx.doi.org/10.30659/jp.13.2.144-155.

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Penelitian ini bertujuan untuk mengetahui hubungan antara rasa memiliki dan komitmen dengan motivasi berprestasi pemain futsal fakultas di Universitas Islam Sultan Agung (Unissula) Semarang. Penelitian ini menggunakan metode penelitian kuantitatif yang dilakukan pada 99 orang pemain futsal dari tiap fakultas. Penelitian ini menggunakan 3 skala pengukuran, yaitu Skala Motivasi Berprestasi, SOBI�P, dan Skala Komitmen. Skala Motivasi Berprestasi berjumlah 21 aitem dengan rentang daya beda 0,254�0,527 dan koefisien reliabilitas sebesar 0,771. SOBI�P berjumlah 17 aitem dengan rentang daya beda 0,569�0,732 dan koefisien reliabilitas sebesar 0,938. Skala Komitmen berjumlah 20 aitem dengan rentang daya beda 0,323�0,504 dan koefisien reliabilitas sebesar 0,831. Teknik analisis data yang digunakan yaitu analisis regresi dua prediktor dan korelasi parsial. Hasil uji hipotesis pertama menunjukkan ada hubungan yang sangat signifikan antara rasa memiliki dan komitmen dengan motivasi berprestasi, dimana korelasi R=0,757 dan Fhitung=61,948 dengan taraf signifikansi sebesar 0,000 (p < 0,01). Hasil uji hipotesis kedua menunjukkan ada hubungan positif yang signifikan antara rasa memiliki dengan motivasi berprestasi, dimana korelasi ryx1-x2= 0,252 dengan taraf siginifikansi p = 0,012 (p < 0,05). Hasil uji hipotesis ketiga menunjukkan ada hubungan positif yang sangat signifikan antara komitmen dengan motivasi berprestasi, dimana korelasi ryx1-x2 = 0,630 dengan taraf signifikansi p = 0,000 (p < 0,01).

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Uchiyama, H., BA Barut, D. Chauhan, SA Cannistra et KC Anderson. « Characterization of adhesion molecules on human myeloma cell lines ». Blood 80, n^o 9 (1 novembre 1992) : 2306–14. http://dx.doi.org/10.1182/blood.v80.9.2306.2306.

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Abstract In multiple myeloma, malignant plasma cells are localized in marrow and rarely circulate in peripheral blood. To investigate the role of adhesion proteins in this process, we determined the expression and function of adhesion molecules on cell lines derived from patients with myeloma. The U266, ARH-77, IM-9, and HS-Sultan cell lines strongly expressed beta 1 and alpha 4 integrins (89% to 98% positive), confirming that VLA-4 is the principal integrin on these cell lines. The U266 and IM-9 cell lines also expressed alpha 3 integrin on 15% to 20% cells. In contrast, all lines lacked cell surface alpha 2, alpha 5, and alpha 6 integrin expression (< 5% positive). These cell lines adhered to fibronectin (20% to 40% specific binding), without significant binding to either collagen or laminin. Adhesion of these cell lines to fibronectin was partially blocked with either anti-beta 1 integrin monoclonal antibody (MoAb) (75% inhibition), anti-alpha 4 integrin MoAb (75% inhibition), or RGD peptide (50% inhibition), but was unaffected by anti-alpha v beta 3 or anti-alpha IIb beta 3 MoAbs. Moreover, the combination of anti-beta 1 plus RGD peptide or anti-alpha 4 plus RGD peptide inhibited binding to fibronectin by 80% and 95%, respectively. Finally, pretreatment and coculture of the IM-9 cell line with interleukin-6 (IL-6) resulted in a 52% decrease in specific binding to fibronectin (30% +/- 6% to 15% +/- 6%; P = .001), associated with a decrease in the number of cells expressing VLA-4 and a decrease in intensity of VLA-4 expression. These data suggest that myeloma cells adhere to fibronectin through VLA-4 as well as through RGD-dependent mechanisms, and that this binding can be downregulated by IL-6. Future studies of binding of both myeloma cell lines and freshly isolated tumor cells to extracellular matrix proteins and to marrow stroma may enhance our understanding of localization and trafficking of cells within the bone marrow microenvironment.

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Uchiyama, H., BA Barut, D. Chauhan, SA Cannistra et KC Anderson. « Characterization of adhesion molecules on human myeloma cell lines ». Blood 80, n^o 9 (1 novembre 1992) : 2306–14. http://dx.doi.org/10.1182/blood.v80.9.2306.bloodjournal8092306.

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In multiple myeloma, malignant plasma cells are localized in marrow and rarely circulate in peripheral blood. To investigate the role of adhesion proteins in this process, we determined the expression and function of adhesion molecules on cell lines derived from patients with myeloma. The U266, ARH-77, IM-9, and HS-Sultan cell lines strongly expressed beta 1 and alpha 4 integrins (89% to 98% positive), confirming that VLA-4 is the principal integrin on these cell lines. The U266 and IM-9 cell lines also expressed alpha 3 integrin on 15% to 20% cells. In contrast, all lines lacked cell surface alpha 2, alpha 5, and alpha 6 integrin expression (< 5% positive). These cell lines adhered to fibronectin (20% to 40% specific binding), without significant binding to either collagen or laminin. Adhesion of these cell lines to fibronectin was partially blocked with either anti-beta 1 integrin monoclonal antibody (MoAb) (75% inhibition), anti-alpha 4 integrin MoAb (75% inhibition), or RGD peptide (50% inhibition), but was unaffected by anti-alpha v beta 3 or anti-alpha IIb beta 3 MoAbs. Moreover, the combination of anti-beta 1 plus RGD peptide or anti-alpha 4 plus RGD peptide inhibited binding to fibronectin by 80% and 95%, respectively. Finally, pretreatment and coculture of the IM-9 cell line with interleukin-6 (IL-6) resulted in a 52% decrease in specific binding to fibronectin (30% +/- 6% to 15% +/- 6%; P = .001), associated with a decrease in the number of cells expressing VLA-4 and a decrease in intensity of VLA-4 expression. These data suggest that myeloma cells adhere to fibronectin through VLA-4 as well as through RGD-dependent mechanisms, and that this binding can be downregulated by IL-6. Future studies of binding of both myeloma cell lines and freshly isolated tumor cells to extracellular matrix proteins and to marrow stroma may enhance our understanding of localization and trafficking of cells within the bone marrow microenvironment.

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Perdana Prasetya, Eska, et Shinta Neni Hardianty. « KONTRIBUSI PROFESI KEGURUAN PADA PENDIDIKAN ANUBAN DI SULAM DARUL AMAN SCHOOL ». Abdi Dosen : Jurnal Pengabdian Pada Masyarakat 4, n^o 3 (2 septembre 2020) : 298. http://dx.doi.org/10.32832/abdidos.v4i3.682.

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Thailand merupakan negara yang bersistem pendidikan hampir sama dengan Indonesia, dan thailand juga mewajibkan bagi masyarakatnya untuk belajar wajib 12tahun, mulai dari pendidikan dasar (pratthom) hingga tahap setara Menengah Atas (Matthayom). Sebelum menginjak tahap pratthom, umumnya diantara mereka banyak yang memasukan anaknya sekolah setara TK (Anuban) dengan tahapan Anuban 1, 2 dan 3 dimulai dari umur 3-5tahun, Dengan harapan anak anak dapat mempunyai persiapan pendidikan dasar sebelum memasuki sekolah pratthom. Namun beda halnya dengan Indonesia, di Thailand ini anak anak usia dini dididik untuk dapat hidup mandiri tanpa didampingi oleh orangtua. Guru anak usia dini dituntut untuk dapat membuat kemandirian dan kemahiran anak muncul. Untuk itu guru harus dapat menggunakan banyak cara atau metode untuk menarik minat anak usia dini, agar dapat tertarik untuk mengikuti kegiatan belajar di sekolah. melihat dari kondisi tempat yang diteliti, sekolah ini merupakan salah satu sekolah yang mempunyai keterbatasan ekonomi. sehingga guru sangat ditantang agar dapat menciptakan pembelajaran dan media yang dapat menarik siswa untuk belajar.

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Al Hasani, Khamis M., Abdulaziz A. Bakathir, Ahmed K. Al-Hashmi, Badar Al Rawahi et Abdullah Albakri. « Modified Le Fort I Osteotomy and Genioplasty for Management of Severe Dentofacial Deformity in β-Thalassaemia Major : Case report and review of the literature ». Sultan Qaboos University Medical Journal [SQUMJ] 20, n^o 3 (5 octobre 2020) : 362. http://dx.doi.org/10.18295/squmj.2020.20.03.018.

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β-thalassaemia major is an autosomal recessive form of haemoglobinopathy that is characterised by complete lack of production of the β-chains resulting in multiple complications that include severe anaemia, failure to thrive and skeletal abnormalities. Facial deformities induced by β-thalassaemia major are rare and are very challenging to treat from a surgical point of view. We report a 33-year-old female patient with β-thalassaemia major who presented to the Dental & Maxillofacial Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman, in 2017 with gross dentofacial skeletal deformity contributing to her psychosocial issues. The facial deformity was corrected surgically by excision of the enlarged maxilla, modified Le Fort I osteotomy and advancement genioplasty. This case highlights the pre-operative preparation, surgical management, encountered complications and treatment outcome within 24 months of follow-up.Keywords: Beta-Thalassaemia; Thalassaemia Major; Cooley's Anemia; Le Fort Osteotomy; Genioplasty; Dentofacial Deformities; Case Report; Oman.

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Oktaviana, Doni, et Mustofa Abi Hamid. « Room Borrowing Information System Website Based using PHP and MySQL with Waterfall Model ». Journal of Vocational Education Studies 4, n^o 2 (25 décembre 2021) : 210–18. http://dx.doi.org/10.12928/joves.v4i2.4400.

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Research by developing an information system is a research that aims to produce and develop an information service system design in the form of website-based rooms lending using PHP as a programming language and MySQL as a database that will be used at the Faculty of Teacher Training and Education, Sultan Ageng Tirtayasa University in-room management as room loan, room loan schedule, room loan data, and room information. This study uses the waterfall development model, with 5 (five) stages of development including the stages of communication, planning, modelling, construction and deployment. This research used Alpha and Beta testing to 3 (three) media experts and 31 (thirty-one) users including 1 (one) admin and 30 (thirty) students. Data collection techniques using interview techniques, observation and dissemination of research instruments. With data analysis in the form of a feasibility test using a Likert scale instrument of 4 (four) assessment scores to media experts and respondents. The final product produced is a website for rooms loaning information system, by average score by media experts (Alpha Testing) of 71.6 with the "very feasible" category. The results of the feasibility test by users (Beta Testing) were 34.32 with the "very feasible" category. Therefore, it can be concluded that the website-based room loan information system is very feasible to use.

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Purnawan, Irfan, et Sugono Sugono. « PENGARUH KONSENTRASI NAOH TERHADAP RENDEMEN β-NAFTOL PADA PROSES PEMBUATAN -NAFTOL ». JURNAL KONVERSI 5, n^o 1 (1 avril 2016) : 31. http://dx.doi.org/10.24853/konversi.5.1.31-38.

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Warna memiliki peran penting dalam memberikan daya tarik terhadap suatu produk, sehingga penggunaan zat pewarna baik yang alami maupun sintesis menjadi kebutuhan yang tidak dapat dihindarkan. β-naphtol merupakan salah satu zat pewarna sintesis yang biasa digunakan sebagai zat pewarna pakaian. Penelitian ini bertujuan untuk mencari pengaruh konsentrasi Natrium Hidroksida terhadap rendemen β-naphtol. Metode yang digunakan dalam penelitian ini adalah metode sulfonasi. Naftalen direaksikan dengan H2SO4 dan dipanaskan hingga suhu 170oC, lalu ditambahkan soda abu dengan mempertahankan suhunya dan didiamkan hingga tercapai suhu ruangan. Kemudian ditambahkan larutan lime dan disaring. Filtrat merupakan kristal sodium naftalena sulfat yang selanjutnya ditambahkan larutan NaOH, dipanaskan hingga suhu 300oC dan didinginkan hingga suhu ruangan. Selanjutnya diencerkan dengan air panas dan diteteskan HCl pekat berlebih, maka akan terbentuk endapan kristal β-naphtol yang dapat ditimbang beratnya. Hasil penelitian didapat konsentrasi NaOH terbaik yaitu 1,25 mol dengan persamaan y = 9,9737X + 81,905 dan R2 = 0,8519. Kesimpulan yang didapat adalah semakin tinggi konsentrasi NaOH, memberikan rendemen β-naphtol yang semakin tinggi juga hingga konsentrasi sebesar 1,25 mol. Namun setelah konsentrasi NaOH dinaikan ke 1,5 mol, rendemen mengalami penurunan. Kata kunci: naphtol, rendemen, pewarna alami, sintesis

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Parlati, Francesco, Monette Aujay, Siv Lise Bedringaas, Susan Demo, Bjorn Gjertsen, Eileen Goldstein, Jing Jiang et al. « Anti-Tumor Activity of Immunoproteasome Selective Inhibitors. » Blood 110, n^o 11 (16 novembre 2007) : 1599. http://dx.doi.org/10.1182/blood.v110.11.1599.1599.

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Abstract Background: The immunoproteasome is a form of the proteasome that is distinct from the broadly expressed constitutive proteasome. The immunoproteasome, which is predominant in hematopoetic cells, contains the unique active site subunits, LMP7, LMP2 and MECL1, accounting for the chymotrypsin-like, caspase-like and trypsin-like activity respectively. The proteasome inhibitors bortezomib and carfilzomib have validated the proteasome as a therapeutic target in hematologic malignancies; however these inhibitors target both the constitutive and immunoproteasome. We hypothesized that selective inhibition of the immunoproteasome would have anti-tumor activity on hematologic tumors and may avoid toxicities associated with constitutive proteasome inhibition. Methods: The level of immunoproteasome expression in hematologic malignant cells was not known. Hematologic tumor cell lines and primary patient samples were assessed for relative levels of immunoproteasome versus constitutive proteasome using an ELISA that quantitates proteasomal subunits. Epoxyketone-based inhibitors were generated that are >20-fold selective for the immunoproteasome subunit, LMP7, over the corresponding constitutive subunit, Beta5. Anti-tumor activity of LMP7 selective inhibitors was determined by treating tumor cell lines and primary patient cells that are predominately LMP7 expressing. Furthermore, anti-tumor effects were assessed by combining LMP7 and Beta5 inhibition using genetic and chemical methods Results: Immunoproteasome expression was variable in primary patient samples and tumor cell lines. In the majority of acute myeloid leukemia, acute lymphocytic leukemia, and chronic lymphocytic leukemia patient samples, the immunoproteasome accounted for >95% of the total proteasome. In HS-Sultan, Molt4 and RL cell lines, the immunoproteasome accounted for 70%, 50% and 50% of the total proteasome, respectively. In these cell lines, complete inhibition of LMP7 was not sufficient to induce to cell death. LMP7 selective inhibitors were only cytotoxic in these cell lines under conditions where Beta5 was depleted either genetically or chemically. Genetic depletion was accomplished using Beta5-specific shRNA expression in HS-Sultan, Molt4 and RL cells which increased the relative LMP7 levels to 95%, 80% and 70% respectively. These cells were significantly more sensitive to LMP7 inhibition than their parental cells, suggesting that cell kill requires suppression of LMP7 and Beta5. Chemically, combinations of Beta5 and LMP7 selective inhibitors showed similar results, i.e. greater cytotoxicity in combination than either inhibitor alone. Acute lymphocytic leukemia patient samples were screened for LMP7 expression and anti-tumor activity of the LMP7 selective inhibitors correlated with the relative levels of LMP7 expression. Conclusion: This work suggests that tumor cells with high relative levels of LMP7 will be sensitive to LMP7 selective inhibition. These results support the development of immunoproteasome-selective inhibitors for the treatment of hematologic malignancies where high levels of immunoproteasome expression are observed. An LMP7 selective inhibitor has been identified as a clinical candidate for development in leukemia.

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Mahdiatunnisa, Sharah, et Abdurrohim Abdurrohim. « HUBUNGAN ANTARA KEPUASAN KERJA DENGAN KONFLIK PERAN GANDA PADA PERAWAT WANITA YANG SUDAH MENIKAH DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG ». Proyeksi 15, n^o 1 (10 avril 2020) : 78. http://dx.doi.org/10.30659/jp.15.1.78-87.

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Penelitian ini bertujuan untuk mengetahui hubungan antara konflik peran ganda dengan kepuasan kerja pada perawat wanita yang sudah menikah dan memiliki anak. Variabel tergantung dalam penelitian ini adalah konflik peran ganda dan variabel bebas kepuasan kerja. Penelitian ini menggunakan metode kuantitatif. Analisa dilakukan kepada 96 perawat wanita yang sudah menikah dan memiliki anak di Rumah Sakit Islam Sultan Agung Semarang. Metode pengambilan data dalam penelitian ini menggunakan skala konflik peran ganda dan skala kepuasan kerja. Skala konflik peran ganda berjumlah 36 aitem dengan rentang daya beda skala konflik peran ganda 0,361- 0,749 dan memiliki koefisien reliabilitas sebesar 0,925. Skala kepuasan kerja berjumlah 30 aitem dengan rentan daya beda skala kepuasan kerja 0,316- 0,630 dan memiliki koefisien reliabilitas sebesar 0,867. Analisa data dalam penelitian ini mengguanakan teknik korelasi product moment dari Pearson. Berdasarkan analisa product moment diperoleh nilay rxy sebesar -0,202 dengan taraf signifikansi p=0,024 (p<0,05). Hasil ini menunjukkan terdapat hubungan negatif yang signifikan antara konflik peran ganda dengan kepuasan kerja pada perawat wanita yang sudah menikah dan memiliki anak.��

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Supradewi, Ratna, et Alfira Sukmawati. « HUBUNGAN ANTARA DUKUNGAN SOSIAL DENGAN PENERIMAAN DIRI PADA PASIEN WANITA PENDERITA KANKER PAYUDARA PASCA MASTEKTOMI DI RUMAH SAKIT ISLAM SULTAN AGUNG SEMARANG ». Proyeksi 14, n^o 1 (11 août 2020) : 32. http://dx.doi.org/10.30659/jp.14.1.32-42.

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Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan sosial dengan penerimaan diri wanita pasien kanker payudara.Penelitian ini menggunakan metode kuantitatif korelasional dengan subjek berjumlah 80 pasien kanker payudara. Teknik dalam pengambilan sampel menggunakan teknik purposive sampling. Metode pengumpulan data menggunakan skala penerimaan diri dan dukungan sosial. Skala penerimaan diri berjumlah 25aitem berdaya beda tinggi dengan koefisien korelasi skor aitem total bergerak antara 0,364 � 0,739 dengan reliabilitas 0,928. Sedangkan skala dukungan sosial berjumlah 29 aitem berdaya beda tinggi dengan koefisien korelasi skor aitem total bergerak antara 0,341 � 0,693 dengan skor reliabilitas sebesar 0,914. Hasil analisis uji normalitas dari data penerimaan diri menunjukkan nilai KS-Z sebesar 1,176 dengan taraf signifikansi sebesar 0,126 (p>0,05) dan hasil analisis data dukungan sosial menunjukkan nilai KS-Z sebesar 0,998 dengan P=0,273 (p>0,05). Hasil uji linieritas antara variabel penerimaan diri dengan variabel dukungan sosial diperoleh skor Flinier sebesar 137,788 dengan taraf signifikasi p = 0.000 (p<0.05). Uji hipotesis menggunakan teknik analisis Product Moment dengan rxy = 0,799 dengan taraf signifikansi p = 0.000 (p<0,01) yang menunjukkan ada hubungan positif yang signifikan antara dukungan sosial dengan penerimaan diri wanita pasien kanker payudara di rumah sakit Islam Sultan Agung Semarang. Variable dukungan sosial memberikan sumbangan efektif sebesar 63,9% terhadap penerimaan diri, sisanya 36,1% dipengaruhi oleh faktor yang lain.

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Bosworth, C. Edmund. « An Oriental Samuel Pepys ? Abu'l-Faḍl Bayhaqī's Memoirs of Court Life in Eastern Iran and Afghanistan, 1030–1041 ». Journal of the Royal Asiatic Society of Great Britain & ; Ireland 14, n^o 1 (avril 2004) : 13–25. http://dx.doi.org/10.1017/s1356186304003876.

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“An oriental Samuel Pepys”. The phrase has been lodged in my mind for the several decades during which I have been working, on and off, on this early Persian historian Bayhaqī. I am pretty certain that I read it originally in that monument of mid-Victorian Anglo-Indian scholarship, The History of India as told by its own Historians. The Muhammadan period, by Sir Henry Elliott and John Dowson. This multi-volume work consists of translated extracts, many quite lengthy, from texts illustrating the history of the Indian subcontinent, the greater part of them dealing with what was then some eleven centuries of Muslim rule there. In Volume II, the compilers presented several passages from Bayhaqī's work, The History of Sultan Maʿsūd of Ghazna, which had just appeared in a printed edition at Calcutta in the Bibliotheca Indica series, edited by the person who had in fact produced the pioneer catalogue of the Royal Asiatic Society's Arabic and Persian manuscripts, William H. Morley. Elliott made many translations himself, but sometimes employed local munshis, not always with happy results. Although Persian culture was still very much alive in India in the mid-nineteenth century, these munshis were far from being au fait with the early eleventh-century Persian style of Bayhaqī and were at times flummoxed by his idiomatic usages. One of my favourites here is the Persian saying ṭablī zīr-i gilīm mīzadand, translated literally and ludicrously in its context as “they were beating a drum under a carpet”. Why anyone should crawl under a carpet and beat a drum, in the midst of a high-level discussion between Sultan Maʿsūd and his administrators, the equivalent of a cabinet meeting, is rather baffling; the idiom, already used by Firdawsī in the national epic, the Shāh-nāma, means of course “to spread rumours clandestinely”.

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Suvannasankha, Attaya, Dawei Xu et Rafat Abonour. « The Protein Kinase C beta (PKCβ) Inhibitor Enzastaurin HCl (LY317615) Augments Chemosensitivity of Multiple Myeloma (MM) Cells to Dexamethasone and the Proteasome Inhibitor Bortezomib. » Blood 104, n^o 11 (16 novembre 2004) : 4382. http://dx.doi.org/10.1182/blood.v104.11.4382.4382.

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Abstract PKCβ isoforms are important in B-cell signaling and proliferation. PKCβ overexpression in diffuse large B-cell lymphoma relates with poor prognosis but the clinical significance of PKCβ in MM is not yet established. Herein, we report antimyeloma activity of the PKCβ inhibitor enzastaurin HCl (LY317615) both as a single agent and in combination with bortezomib and dexamethasone. Methods: Six MM cell lines (NCI-H929, RPMI8226, IM9, U266, ARH-77 and HS Sultan) with varying degree of PKC activity were treated with graded dose of enzastaurin and studied for induction of apoptosis by flow cytometric analysis of annexin and propidium iodide stainings, and inhibition of proliferation by MTT assay. Results: IC50 doses of both effects were low at 1-5 μM in all cell lines and did not correlate with the baseline PKC activity. Interestingly, the combination of enzastaurin at non-toxic concentrations with varying doses of dexamethasone and bortezomib yielded synergistic enhancement of cell death and inhibition of proliferation in all cell lines. Multiparameter immunoblottings of cell lysate after enzastaurin treatment showed that, at these functional doses, PI3/AKT, Erk and JNK pathways were unaffected. Additional studies are ongoing to evaluate the effect of enzastaurin on activities of apoptotic proteins, and verify its effect in primary samples. Conclusions: Our preliminary data indicate that the PKCβ inhibitor enzastaurin demonstrates single-agent antimyeloma activity and can sensitize MM cells to bortezomib and dexamethasone. Enzastaurin is promising for further studies as an approach to increase activity and decrease toxicity of MM therapy. Figure Figure

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Al Saifi, Said Ahmed, Badriya Al Adawi et Ikram Burney. « Patterns of Bacterial Isolates and their Resistance to Antibiotics in Patients with Chemotherapyinduced Febrile Neutropenia at a University Hospital ». Oman Medical Journal 36, n^o 4 (15 juillet 2021) : e290-e290. http://dx.doi.org/10.5001/omj.2021.87.

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Objectives: Febrile neutropenia is a major complication of cytotoxic chemotherapy and is associated with a high rate of mortality and morbidity if not treated appropriately. Consequently, it is important to know the bacterial spectrum and pattern of its resistance in each hospital to formulate an appropriate empiric antibiotic regimen. We sought to study the bacterial spectrum in patients with chemotherapy-induced neutropenia and report their resistance patterns. Methods: We conducted a retrospective study on patients admitted with febrile neutropenia between January 2010 and December 2016 in the oncology unit at Sultan Qaboos University Hospital in Oman. Consecutive patients diagnosed with non-hematological malignancies who had febrile neutropenia and positive blood culture were included in this study. Results: A total of 76 bacterial isolates were documented in 67 episodes in 62 patients. There were 26 male and 36 female patients. The median age was 51 (14–81) years. The most common cancers were breast cancer (17.7%), non-Hodgkin lymphoma (16.1%), and colon cancer (14.5%). Gramnegative and gram-positive organisms accounted for 73.7% and 26.3% of all isolates, respectively. The most common gram-negative organisms were Pseudomonas aeruginosa (26.8%), Escherichia coli (23.2%), Klebsiella species (17.9%), and Acinetobacter baumannii (12.5%). The most common gram-positive organisms were Staphylococcus aureus (30.0%), followed by coagulase-negative Staphylococcus (25.0%). There were 14 multidrugresistant organisms and eight extended-spectrum beta-lactamases (ESBL). The resistance among gram-negative organisms to the commonly used broad-spectrum antibiotics was 23.5–55.6%. No resistance was recorded against vancomycin amongst the gram-positive organisms. Eight (12.1%) patients died while neutropenic. Conclusions: Gram-negative organisms were the predominant organisms. There is a high rate of resistance to the commonly used antibiotics. Using a combination of antibiotics is warranted in patients presenting with chemotherapy-induced febrile neutropenia.

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Evriani Mareza, Karlin Agustina Bastomi, Yursida et Muhamad Syukur. « Keragaan Agronomi Cabai Keriting (Capsicum annuum L.) IPB di Lahan Pasang Surut Sumatera Selatan ». Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 49, n^o 2 (30 août 2021) : 169–76. http://dx.doi.org/10.24831/jai.v49i2.36005.

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Penggunaan cabai keriting sebagai bahan makanan terus meningkat. Dibutuhkan peningkatan produksi melalui penggunaan varietas unggul dengan memanfaatkan lahan pasang surut yang banyak terdapat di Sumatera Selatan. Penelitian bertujuan mendapatkan genotipe cabai keriting IPB yang memiliki keragaan agronomi yang unggul dan berpotensi untuk dikembangkan di lahan pasang surut Sumatera Selatan. Penelitian dilaksanakan bulan Juli 2020 sampai Januari 2021 di lahan pasang surut sulfat masam potensial dengan luapan tipe C menggunakan rancangan acak kelompok dengan tiga ulangan. Genotipe yang diuji adalah enam cabai keriting IPB F10-120005-141-16-35-3-2B, F10-120005-141-16-35-1-4-3B, F10-120005-141-16-35-7-1-3B, F10-120005-241-2-9-4-4-1-1B, F10-120005-120-7-1-7-8-1-2B, F11-0005-9-6, dan empat genotipe pembanding SSP, Laris, Caman, F1-PM999. Data dianalisis ragam dengan uji lanjut Beda Nyata Jujur. Hubungan antar peubah dianalisis korelasi Pearson. Genotipe uji F10-120005-120-7-1-7-8-1-2B memiliki batang tinggi dan menghasilan bobot per buah lebih tinggi dari genotipe pembanding, karena didukung oleh tebal daging buah tertinggi, buah yang panjang, dan diameter buah terbesar. Genotipe IPB F10-120005-141-16-35-1-4-3B, F10-120005-141-16-35-7-1-3B, F10-120005-241-2-9-4-4-1-1B, F10-120005-120-7-1-7-8-1-2B berpotensi untuk dikembangkan sebagai varietas unggul di lahan pasang surut sulfat masam potensial Sumatera Selatan, dengan produktivitas 11.38 ton ha-1 sampai 12.92 ton ha-1. Genotipe cabai keriting mempunyai kemampuan tumbuh yang berbeda di lahan pasang surut, tergantung kemampuannya beradaptasi dengan lingkungan tumbuh sesuai dengan sifat genetik yang dimiliki. Kata kunci: genotipe adaptif, genotipe pembanding, genotipe uji, lahan suboptimal

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Rantika, Nopi. « Mengenal Produk Perawatan Rambut yang Baik ». Farmasetika.com (Online) 2, n^o 4 (25 août 2017) : 4. http://dx.doi.org/10.24198/farmasetika.v2i4.15892.

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Beberapa orang mengeluarkan uang untuk melakukan perawatan rambut. Banyak produk yang beredar dipasaran, dengan merek yang berbeda-beda. Terdapat beberapa bahan kimia di balik shampo dan conditioner rambut yang biasa digunakan, yang membuat rambut terlihat mengkilap dan indah. Rambut perlu pH agak asam (sekitar pH 4-5). Pada pH ini ikatan non kovalen pada untai rambut akan terjaga. Sabun memiliki pH agak basa (kira-kira pH 8.5), yang dapat menyebabkan beberapa interaksi non kovalen seperti ikatan disulfida, sehingga melemahkan rambut. Saat ini, mayoritas sampo menggunakan surfaktan yang tidak berasal dari sabun. Surfaktan yang digunakan saat ini adalah anionik (mis.bermuatan negatif), seperti natrium lauril sulfat. Hilangnya lapisan minyak pada rambut bisa membuat rambut telihat kusut, kusam dan terasa kering. Menggunakan kondisioner setelah keramas dapat melindungi ramut, rambut akan terlihat lebih lembut dan berkilau. Pembentuk busa adalah bahan surfaktan yang masing-masing berbeda daya pembuat busanya. Busa adalah emulsi udara dalam cairan. Bahan tambahan lainnya seperti pengental, pemisah logam, penyeimbang pH, dan pewarna sering digunakan dalam produk perawatan rambut.Kata kunci : rambut, shampo, surfaktan, sabun

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Rachmawati, Nurmeily, et Diana Rinawati. « PROFILE ADSORBEN SEBAGAI MEDIA FILTER DALAM MENURUNKAN KONSENTRASI KONTAMINAN PADA BADAN AIR BAKU SUNGAI CISADANE ». Jurnal Medikes (Media Informasi Kesehatan) 7, n^o 2 (23 décembre 2020) : 357–64. http://dx.doi.org/10.36743/medikes.v7i2.240.

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Salah satu sumber kehidupan yang dibutuhkan manusia adalah kebutuhan akan air bersih. Untuk mendapatkan air bersih dapat dilakukan dengan memanfaatkan sumber air yang ada salah satunya air sungai. Sumber air ini tak luput dari pencemaran akibat aktivitas manusia maupun dari lingkungan sekitar. Sungai Cisadane yang terletak didaerah Tangerang dimanfaatkan masyarakat sekitar sebagai salah satu sumber air. Dalam mendapatkan air bersih perlu dilakukan usaha salah satunya memanfaatkan media filter air. Penelitian ini bertujuan mendapatkan informasi profiling dari penggunaan adsorben sebagai media filter dalam rangka menurunkan konsentrasi kontaminan yang terdapat di Air Sungai Cisadane. Metode yang digunakan dalam penelitian ini yaitu eksperimental dengan pengulangan sebanyak tiga kali. Adsorben alami yang digunakan dalam penelitian ini berjumlah 8 yaitu arang aktif (AA), pasir silika (PS), zeolit (Z), sekam padi bakar (SPB), sekam padi kering (SP), serabut kelapa (CH), serbuk kayu (SK), dan jerami padi (JP). Bahan kontrol yang digunakan yaitu Air Sungai Cisadane tanpa difilterisasi menggunakan adsorben. Hasil filterisasi menggunakan kedelapan adsorben akan diuji terhadap parameter fisika dan kimia. Pengujian hasil filterisasi dilakukan di laboratorium PDAM Cikokol. Hasil yang diperoleh pada parameter fisika menunjukkan pada adsorben zeolite dan pasir silica memberikan hasil yaitu tidak berasa dan berbau. Pada uji nilai kekeruhan hasil filterisasi menggunakan zeolith diperoleh hasil 5,82 NTU. Untuk parameter kimia diperoleh hasil penurunan konsentrasi kontaminan sulfat pada adsorben jerami menjadi 10 mg/L dan pada adsorben zeolite memberikan penurunan kadar nitrat yaitu 1,3 mg/L. Berdasarkan uji t-test antara sebelum dan sesudah filterisasi menunjukkan adanya perbedaan beda nyata pada parameter fisika (rasa, bau, zat padat terlarut) dengan nilai Sig (2-tailed) < ά = 0.025, dan tidak menunjukkan beda nyata yang signifikan pada parameter kimia dengan nilai Sig (2-tailed) > ά = 0.025.

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Tony, Surekha, Shahina Daar, Shoaib Al Zadjali, Murtadha K. Al-Khabori, Mohammed El Shinawy et Yasser Wali. « T2* MRI in Hypertransfused Children with Thalassemia Intermedia : Serum Ferritin Does Not Reflect the Reality ». Blood 118, n^o 21 (18 novembre 2011) : 5304. http://dx.doi.org/10.1182/blood.v118.21.5304.5304.

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Abstract Abstract 5304 Background: Non-transfused patients with thalassemia intermedia (TI) accumulate iron in their body due to increased gastrointestinal absorption of iron and release of iron from the macrophages. Earlier studies have revealed that serum ferritin does not reflect the severity of iron overload in non-transfused TI patients. The current study aims at evaluating the iron overload status in a group of young hypertransfused TI children. Materials and Methods: Eleven patients (mean age 13.18±4.094 years) with TI on regular follow-up at the Pediatric Thalassemia Day Care Centre, Sultan Qaboos University Hospital, Oman were included in the study after approval by the Medical Research and Ethics Committee. All patients had beta gene mutational analysis. They were diagnosed as intermedia because of their definitive TI mutation, late age at presentation (>5 years) and transfusion independence (mean baseline Hb 6.9 g/dl). Patients were treated conventionally with hypertransfusion, and chelation, as guided by their serum ferritin levels. Serum ferritin (2 monthly) was analyzed using the Beckman Coulter Access 2 Immunoassay System. Based on serum ferritin levels, patients were classified into 2 groups, group 1(six patients) and 2 (five patients) with serum ferritin levels below and above 1000 ng/ml respectively. All patients underwent cardiac T2* MRI assessment. Based on local reference values for T2*MRI, quantification of cardiac iron deposition was categorized as normal, mild, moderate and severe iron overload at values > 20 ms, 14–20 ms, 10–14 ms and < 10 ms respectively. Simultaneous liver iron T2* values were categorized into normal, mild, moderate and severe iron overload at values > 9.1 ms, 7.1–9.0 ms, 3.1– 7.0 ms and <3.0 ms respectively. Results: Patients in group 1 and 2 had mean serum ferritin levels of 817.300±244.690 ng/ml and 1983.80±662.862 ng/ml respectively (p = 0.003). Despite this very high variation in serum ferritin values, T2* MRI showed comparable hepatic iron overload status in both the groups with mean hepatic T2* value of 2.51±0.46 ms and 3.4±1.63 ms in group 1 and group 2 respectively. The difference in hepatic T2* between the 2 groups is −0.88 (95% confidence interval −2.44 to 0.68) which is statistically insignificant (p =0.23, t-test). None of the studied patients had myocardial iron deposition (overall mean 36.86±7.8 ms). Other confounders like initial ages at presentation, pre-transfusion hemoglobin levels, durations of transfusion and chelation therapies were statistically insignificant for the 2 groups. No specific pattern of beta gene sequence was noted in either group. Conclusions: We conclude in our patients with TI on hypertransfusion, serum ferritin does not reflect their moderate to severe hepatic iron overload status. Inspite of steady serum ferritin trends, evaluation of iron overload by T2* MRI and optimal chelation is strongly recommended in hypertransfused TI patients. Disclosures: No relevant conflicts of interest to declare.

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Albazi, Bushra A. A., Dr Noof Albaz, Dr Nayef Alqahtani, Dr Angham Salih et Dr Rafat Mohtasab. « Is the Portable Chest Radiographic More Reliable to Reveal Covid19 in Highly Suspicion Patient before Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) Test ? » International Journal of Innovative Research in Medical Science 6, n^o 03 (17 mars 2021) : 228–36. http://dx.doi.org/10.23958/ijirms/vol06-i03/1085.

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A large number of patients with coronavirus disease 2019 (COVID-19) present at hospitals. There are a limited number of isolation rooms open, and patients must often wait a long time to get a reverse transcription-polymerase chain reaction (RT-PCR) test done. This necessitates the introduction of effective triage plans. A patient with suspicions is referred to an emergency room (ED) depending on their medical record for a simple physical assessment, blood test findings, and chest imaging.A retrospective study design was conduct at Prince Sultan Medical Military City (PSMMC). Ethical approval was obtained from the institutional board to wave the consent forms since it is a retrospective study. Only the primary investigator has had the data access to the patients’ medical records. The collected patient records were under specific categories, including symptoms score starts from 5 and above, RT-PCR test result done after CXRP imaging, the patient admitted to the emergency department (ED). Excluding all CXRP done after RT-PCR TEST, positive Covid 19 admitted to the intensive care unit (ICU), pediatric patients, and patients with score symptoms were less than five. Two experienced radiologists reviewed the images blindly, and the inter-observer reliability of observations noted by the radiologists was calculated. As for the relationship between the x-ray reading and the RT-PCR test result, our results showed a high correlation between the variables (chi-square χ² = 12.44, with df =1, and p<0.001). The sensitivity of x-ray diagnosing covid19 was 65.52 %, while the specificity was 54.51 %, and the accuracy of radiologists reading was 58.17 %. Furthermore, the positive predictive value (PPV) was 41.76 %, and the negative predictive value (NPV) was 76.05%. Finally, the false positive rate (type-i error (alpha) was 45.49%, and the false-negative rate (type-ii error (beta) was 34.48% Our research findings show that CXRP imaging can detect COVID-19 infection in symptomatic patients and can be a valuable addition to RT-PCR testing. In an inpatient ED environment where availability of test kits, laboratory equipment, and laboratory personnel is compromised and risks delaying patient treatment and hospital workflow, serial CXRP could theoretically be used as an adjunct diagnostic function and monitoring in patients suspected of having COVID-19.

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Utami, Naning Kisworo, Metty Amperawati et Siti Salamah. « HUBUNGAN KONSUMSI AIR MINERAL DAN AIR SUNGAI DENGAN INDEKS DMF-T DI KALIMANTAN SELATAN ». An-Nadaa Jurnal Kesehatan Masyarakat 9, n^o 1 (5 juin 2022) : 79. http://dx.doi.org/10.31602/ann.v9i1.6904.

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AbstrakAir merupakan kebutuhan pokok bagi kehidupan manusia di bumi ini (Wardhana,2001). Di dalam air terkandung berbagai unsur-unsur mineral sekalipun jumlah dan kandunganya berbeda-beda seperti, kalsium, fluoride, magnesium, sulfat. Kekurangan dan kelebihan dari unsur-unsur mineral tersebut diatas dapat berakibat terganggunya kesehatan gigi dan mulut (Murni, 2001). Karies gigi adalah suatu proses kerusakan yang terbatas pada jaringan keras gigi dimulai dari lapisan email, dentin dan menjalar ke pulpa (Kidd dkk.,1992). Kalimantan Selatan penyakit karies gigi masih termasuk 10 (sepuluh) penyakit terbanyak yang ada dipuskesmas-puskesmas yaitu urutan ke 4 dan 5 dan secara geografis merupakan daerah gambut dimana dengan keadaan lingkungan terutama kandungan airnya. Penelitian bertujuan untuk mengetahui hubungan konsumsi air mineral dan air Sungai dengan indeks DMF-T Di SDN Rantau Kanan dan SDN Sungai Bahalang Kabupaten Tapin Provinsi Kalimantan Selatan. Penelitian ini merupakan penelitian survey analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah kelas IV dan Kelas V. Pengambilan sampel secara Purposive Sampling. Hasil penelitian menunjkkan konsumsi air minum yang berasal dari air sungai dengan indeks DMF-T di SDN Rantau Kanan diperoleh sebanyak 8 (20,5%) baik dan sebanyak 31 (79,5%) buruk, dan SDN Sungai Bahalang Kabupaten Tapin Provinsi Kalimantan Selatan. Sedangkan 43 (84,3%) murid yang mengkonsumsi air mineral indeks DMF-T baik dan 8 (15,7%) buruk. Berdasarkan hasil uji statistic diperoleh nilai p=0,000, maka dapat disimpulkan ada hubungan konsumsi air minum dengan indeks DMF-T Dari hasil analisis diperoleh pula nilai OR = 0.048.

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Zilberberg, Marya, Brian Nathanson et Kate Sulham. « 1420. Descriptive Epidemiology of UTI Hospitalizations in the US, 2018 ». Open Forum Infectious Diseases 8, Supplement_1 (1 novembre 2021) : S794. http://dx.doi.org/10.1093/ofid/ofab466.1612.

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Abstract Background In parallel with an increase in antimicrobial resistance, urinary tract infections (UTI), one of the most common diagnoses among hospitalized patients in the US, have been on the rise. Though mostly emphasized as a hospital-acquired complication among patients with an indwelling catheter, quantification of the full contemporary burden of UTI-associated hospitalizations is limited. Methods We conducted a cross-sectional multicenter study within the National Inpatient Sample (NIS) database, a 20-percent stratified sample of discharges from US community hospitals, from 2018, to explore characteristics of patients discharged with a UTI diagnosis. We divided UTI into mutually exclusive categories of complicated (cUTI), uncomplicated (uUTI), and catheter-associated (CAUTI). We applied survey methods to develop national estimates. Results Among 2,837,385 discharges with a UTI code, 77.9% were uUTI, 17.6% cUTI, and 4.4% CAUTI. Compared to patients with uUTI (mean age 69.0 years), those with CAUTI and cUTI were older (70.1 and 69.7 years), but had same comorbidity burden (mean Charlson 4.3) as cUTI (4.3) and lower than CAUTI (4.6). Compared to other geographic regions, the Northeast had the lowest proportion of uUTI (74.6%) and highest of cUTI (20.8%) while the South had highest uUTI (80.2%) and lowest cUTI (15.7%). Over 60% of all UTI, regardless of type, were in large, and nearly ½ in urban teaching, institutions, and >80% came through the emergency department. Antimicrobial resistance codes were infrequent, but extended spectrum beta-lactamase organisms were more common in CAUTI (2.7%) and cUTI (2.1%) than in uUTI (1.6%). Among the 83.0% of discharges whose UTI was a secondary diagnosis, sepsis was the most common principal diagnosis, ranging from 17.7% in uUTI to 22.3% in cUTI. Although relatively low across the board, hospital mortality was lowest in cUTI (2.8%) and highest in uUTI (3.9%). Discharges to a chronic care facility were most common in CAUTI (46.7%) and least common in cUTI (33.3%). Conclusion There are nearly 3 million hospital admissions with a UTI, comprising fully 8% of all annual admissions in the US. Though most are considered uncomplicated, there are few differences in characteristics or outcomes across the categories. Disclosures Marya Zilberberg, MD, MPH, Cleveland Clinic (Consultant)J&J (Shareholder)Lungpacer (Consultant, Grant/Research Support)Merck (Grant/Research Support)scPharma (Consultant)Sedana (Consultant, Grant/Research Support)Spero (Grant/Research Support) Brian Nathanson, PhD, Lungpacer (Grant/Research Support)Merck (Grant/Research Support)Spero (Grant/Research Support) Kate Sulham, MPH, Spero Therapeutics (Consultant)

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Melnick, David, Akash Jain, Vikas Gupta et Katherine Sulham. « 1684. Hospital Costs and Reimbursement in Patients with Resistant Enterobacteriaceae (ENT) Urinary Tract Infection (UTI) in the United States (US) : A Multicenter Analysis ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S826. http://dx.doi.org/10.1093/ofid/ofaa439.1862.

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Abstract Background Rates of fluoroquinolone resistance (FQ-R) and third-generation cephalosporin resistance/extended-spectrum beta-lactamases (ESBL+) are rising. These pathogens generally retain susceptibility to intravenous (IV) carbapenems; however, the loss of susceptibility to commonly used oral (PO) antibiotics limits the opportunity to transition these patients home, leading to increased length of stay (LOS) and higher costs. Here, we evaluate the hospital LOS, costs and reimbursement for UTI hospitalizations. Methods We analyzed the first positive enterobacteriaceae (ENT) urine culture ≤ 3 days from hospital admission in patients with a primary or secondary UTI ICD10 discharge diagnosis from 68 US hospitals admitted October 1, 2015-2017. Patient characteristics and outcomes were categorized by ESBL+ and FQ-R status. IV to PO was identified as PO therapy after 24 hours of IV. Outcomes were stratified by resistance and PO conversion status. Results 16,022 patients were eligible for analysis; 5,017 (31.3%) were FQ-R, 1,763 (11.0%) were ESBL+, and 1,433 (8.9%) were both FQ-R and ESBL+; 2,367 (14.8%) were converted to PO antibiotics during their hospitalization. Overall, mean LOS, costs, and reimbursement were 5.2 days, $9,303 and $8,501 (mean difference between cost and reimbursement: -$878). Mean LOS was shorter and mean difference between cost and reimbursement was lower overall for patients converted to PO therapy vs. those who did not (4.7 vs. 5.3 days, -$532 vs. -$938). Drug resistance was associated with higher LOS and a larger difference between cost and reimbursement; patients who were FQ-R and ESBL+ and did not convert to PO had a mean LOS of 6.0 days, costs of $11,482, and reimbursement of $9,243 (difference: -$2,446). Mean LOS, costs, and reimbursement for patients who were neither FQ-R nor ESBL+ and who did convert to PO therapy were 4.6 days, $7,904, and $7,496 (difference: -$527), respectively. Conclusion Reduced LOS and substantial cost savings could be recognized by efficiently converting patients receiving IV antimicrobials to PO and discharging them from the hospital. Lack of PO therapies with activity against resistant pathogens has made this challenging; new PO options may help reduce hospital costs and resources required to treat these UTI patients. Disclosures David Melnick, MD, Spero Therapeutics (Employee)Spero Therapeutics (Employee) Akash Jain, PhD, Spero Therapeutics (Employee) Vikas Gupta, PharmD, BCPS, Becton, Dickinson and Company (Employee, Shareholder)GlaxoSmithKline plc. (Other Financial or Material Support, Funding) Katherine Sulham, MPH, Spero Therapeutics (Independent Contractor)

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Huliselan, Mus. « Perdagangan Internasional : Pengaruhnya Terhadap Perubahan Sistem Nilai Budaya Orang Maluku ». Kapata Arkeologi 8, n^o 1 (19 avril 2016) : 9. http://dx.doi.org/10.24832/kapata.v8i1.176.

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AbstrakKeterlibatan Orang Maluku dalam percaturan perdagangan internasional dan perjumpaan dengan berbagai pedagang asing telah membawa perubahan dalam peradaban Orang Maluku. Dari para pedagang asing ini para Sultan dan raja-raja memperoleh pengetahuan tentang: agama, perdagangan, pelayaran maupun berbagai teknologi baru. Perdagangan internasional membawa dampak yang cukup penting bagi kehidupan sosial budaya Maluku, karena menjadi ruang perjumpaan berbagai Negara dengan latar budaya yang berbeda-beda dan berpengaruh terhadap budaya asli Maluku, namun identitas Maluku tetap terjaga, yakni ciri kebudayaan monodualitas. Dalam kebudayaan monodualistis kedua kelompok harus tetap ada dan satu harus memberikan kemungkinan kepada yang lain untuk tetap hidup, sebab kalau satu tidak ada maka keberadaan yang lain tidak berarti. Dalam waktu bersamaan juga tumbuh ikatan-ikatan persaudaraan yang didasarkan pada nilai tolong menolong antar sesama. Hal ini lahir sebagai upaya penegakan keseimbangan baru dalam perbedaan untuk peredam kekerasan dan keinginan untuk hidup berdampingan secara damai. AbstractThe involvement of the Moluccan in the international trade and the interaction with the foreign traders has brought the transformation in the civilization of tbe Moluccas. Through these foreign traders sultans and the kings achieving knowledge on religion, trade, seafaring and new technologies. The international trade has created major impacts on the social and cultural life in the moluccas asnit save as a interaction space for countries with variois background and has influenced the original cultural of the Moluccas although the identity of the Moluccas is the existed with the monodualism characteristic. In the perspective of the monodualistic culture every group has to still exist and must depend one another to support every part. As the meaning of one always depends on the existence of the other. In the same time the brotherhood relationship has grew based on tbe mutual benefit principal. This phenomenom was existed as an effort to create the new balance in difference to control the conflict and violence and as a good will to live in peace.

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Santi, Santi, Salimin A et Irawaty Irawaty. « PENYEBAB PERBEDAAN JUMLAH MAHAR DALAM KAWIN PINANG (PIKA BHEKA-BHEKA) PADA MASYARAKAT ETNIS CIA CIA (STUDI DI DESA WABULA KECAMATAN WABULA KABUPATEN BUTON PROVINSI SULAWESI TENGGARA) ». SELAMI IPS 12, n^o 2 (1 février 2020) : 141. http://dx.doi.org/10.36709/selami.v12i2.10846.

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Abstrak: Tujuan dari penelitian ini yaitu: a. untuk mengetahui alasan terjadinya perbedaan Jumlah mahar dalam kawin pinang (pika bheka-bheka) pada masyarakat etnis Cia Cia di Desa Wabula Kecamatan Wabula Kabupaten Buton; b. untuk mengetahui proses penyelesaian perbedaan jumlah mahar dalam kawin pinang (pika bheka-bheka). penelitian ini dilaksanakan di Desa Wabula Kecamatan Wabula Kabupaten Buton Provinsi Sulawesi Tenggara. Jenis peneltian yang digunakan adalah jenis penelitian berdasarkan taraf penelitian yaitu penelitian deskriptif yang hanya menggambarkan keadaan objek dengan analisis kualitatif . Subyek penelitian ini terdiri dari 5 (lima) orang yang terdiri dari 2 (dua) orang tokoh ada Wabula sebagai orang yang mengatur tata cara adat dalam pelaksanaan perkawinan pinang (pika bheka-bheka), Kepala Kantor Urusan Agama (KUA) Kecamatan Wabula, 1 (satu) orang Imam/Khatib dan 1 (satu) orang Pegawai Pencatat Nikah (PPN). Teknik pengumpulan data yaitu: wawancara dan dokumenter. Hasil penelitian ini menunjukan bahwa perkawinan adat etnis Cia Cia menurut praktek hukum adat Wabula yang didasarkan pada stratifikasi sosial masyarakat etnis Cia Cia terdiri dari golongan Kaomu, Awalaka, dan Maradika. Adapun jumlah mahar dalam setiap golongan tersebut sangatlah berbeda-beda. Keturunan Sultan dan Sapati akan masuk dalam Kaomu (bangsawan) yang memiliki mahar 150 bhoka untuk jabatan Sultani dan 125 bhoka untuk jabatan Sapati. Golongan Awalaka merupakan golongan yang berasal dari keturunan Bontotoa (jabatan untuk kepala kampung) yang memiliki mahar sebanyak 100 bhoka. Sementara golongan maradika memiliki mahar 12 bhoka 4 kupa. Cara penyelesaian jumlah mahar untuk perkawinan berbeda golongan dapat diselesaikan dengan cara maradika manadikana (kesepakatan adat berdasarkan yang ditetapkan oleh tokoh adat) berdasarkan hukum adat yang berlaku. Kesimpulan dalam penelitian ini adalah bahwa perbedaan jumlah mahar yang terjadi pada masyarakat etnis Cia Cia menurut praktek hukum adat yang tidak tertulis disebabkan oleh stratifikasi yang terjadi di dalam suatau masyarakat tersebut yakni golongan Kaomu, golongan Awalaka, dan golongan maradika. Perbedaan jumlah mahar pada masyarakat etnis Cia Cia dapat diselesaikan dengan cara mardika manadikana.Kata Kunci: Perbedaan Jumlah Mahar, Penyelesaian Jumlah Mahar, dan Perkawinan Pinang

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Melnick, David, Akash Jain, Vikas Gupta et Katherine Sulham. « 1672. Eligibility and Outcomes of Conversion to Oral (PO) Therapy in Patients Hospitalized with Enterobacteriaceae (ENT) Urinary Tract Infection (UTI) in the United States (US) : A Multicenter Analysis ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S821—S822. http://dx.doi.org/10.1093/ofid/ofaa439.1850.

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Abstract Background Rising rates of fluoroquinolone resistance (FQ-R) and third-generation cephalosporin resistance/extended-spectrum beta-lactamases (ESBL+) have left patients with urinary tract infections (UTI) few oral options. Here, we evaluate the eligibility of hospitalized UTI patients to take PO medications and estimate the potential impact on hospital cost and length of stay (LOS). Methods We analyzed the first positive enterobacteriaceae (ENT) urine culture ≤ 3 days from hospital admission in patients with a primary or secondary UTI ICD10 discharge diagnosis from 68 US hospitals admitted October 1, 2015-2017. Eligibility for PO was classified as: (1) received at least 24 hours intravenous (IV) antimicrobial, (2) ability to tolerate PO drug as evidenced by a pharmacy order for non-antibiotic PO medication, (3) stable/normal white blood count (WBC). Fisher’s exact test was used to test for significance; results were examined by severity quartile, PO conversion and resistance status (FQ-R and ESBL+) Results 5,842 patients were eligible for PO conversion and analysis; 1,890 (32.5%) actually converted to PO during their hospital stay; 2,199 (37.6%) were either FQ-R, ESBL+, or both. Baseline demographics were similar between groups. Highly resistant patients (FQ-R and ESBL+) were less likely to transition to PO compared to those with neither FQ-R nor ESBL infections (16.7% vs. 37.0%). Among patients who did convert to PO, post-PO-eligible LOS was shorter across all severity strata compared to patients who did not convert (p< 0.0001). For those who did not convert, post PO-eligible LOS was 2.6, 2.9, 3.3, and 4.0 days by severity quartile, respectively. Among patients who did convert to PO, the total cost was $1,043 less (p=0.024) for patients in the 3rd quartile of severity and $1,512 less (p=0.004) for patients in the 4th quartile of severity, compared to the patients who did not convert. Conclusion Only ~1/3 of patents eligible for PO therapy are converted during hospitalization. Reduced LOS and substantial cost savings could be recognized by efficient PO conversion and hospital discharge. Lack of PO therapies with activity against resistant pathogens has made this challenging; new PO options may help reduce hospital costs and resources required to treat these UTI patients. Disclosures David Melnick, MD, Spero Therapeutics (Employee)Spero Therapeutics (Employee) Akash Jain, PhD, Spero Therapeutics (Employee) Vikas Gupta, PharmD, BCPS, Becton, Dickinson and Company (Employee, Shareholder)GlaxoSmithKline plc. (Other Financial or Material Support, Funding) Katherine Sulham, MPH, Spero Therapeutics (Independent Contractor)

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Chiba, Hiroki, Masayoshi Kobune, Kazunori Kato, Kiminori Nakamura, Yutaka Kawano, Rishu Takimoto, Takuya Matsunaga, Junji Kato, Yoshiro Niitsu et Hirofumi Hamada. « Wnt3 Augments Adhesion Mediated Drug Resistance of Myeloma Cells Via Wnt/RhoA Pathway. » Blood 106, n^o 11 (16 novembre 2005) : 5075. http://dx.doi.org/10.1182/blood.v106.11.5075.5075.

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Abstract Despite the tremendous effort in developing of conventional chemotherapy and molecular targeting drugs for patients with multiple myeloma (MM), it has been proven difficult to completely abrogate neoplastic cells from bone marrow (BM). Hence, patients with refractory disease still experience poor outcome due to disease progression. Principle obstacle in the treatment of this disease is a chemo-resistance which is mainly caused by the interaction of myeloma cells with BM stromal cells. However, little is known about the molecular mechanism of cell adhesion mediated drug resistance (CAM-DR) in MM. In this study, we focused on relationship between drug resistance and expression of Wnts, the factor regulating the cell adhesion and proliferation, in myeloma cells. To gain insight into involvement of Wnt signaling in CAM-DR, we first screened the expression of Wnt family in myeloma cell lines (RPMI8226, ARH77, KMS-5, HS-sultan and MM1S) by reverse transcription (RT)-polymerase chain reaction (PCR) analysis. Although the mRNAs of Wnt2b, Wnt7a and Wnt10b were variably expressed in some of myeloma cell lines, Wnt3 mRNA was detected in all the myeloma cells examined. RPMI8226, ARH77 and KMS-5 which highly expressed Wnt3 protein, tightly adhered to human BM stromal cells and accumulation of beta-catenin and GTP-bounded RhoA was observed in these myeloma cell lines. This cell adhesion was augmented by addition of Wnt3 containing conditioned medium (CM) and suppressed by Wnt-receptor competitor, secreted Frizzled related protein (sFRP)-1, but not by specific inhibitor of canonical pathway (DKK-1). These results suggest that adhesion of myeloma cells was regulated by non-canonical pathway of Wnt signaling. We further examined whether the Wnt3 mediated adhesion to stromal cells involved in CAM-DR. The drug resistance of ARH-77 for doxorubicin was 1.8 folds enhanced by adhesion to stromal cells in comparison with stroma-free condition. This CAM-DR for doxorubicin was further augmented (2.6 folds) by addition of Wnt3 CM via enhancement of adhesion to stromal cells. Moreover, although the doxorubicin sensitivity of ARH-77 in coculture with stromal cells was significantly reduced by sFRP-1, this effect was not observed in stroma-free culture, indicating that Wnt3-mediated CAM-DR is dependent on attachment with stromal cells. Additionally, CAM-DR was completely restrained by addition of Rho kinase inhibitor Y27632. These results indicate that Wnt3 augments myeloma CAM-DR by enhancement of adhesion to human BM stromal cells via Wnt/RhoA signaling. Thus, Wnt/RhoA signaling pathway could be a promising molecular target to overcome CAM-DR.

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Hasdar, Muhamad, Yuny Erwanto et Suharjono Triatmojo. « KARAKTERISTIK EDIBLE FILM YANG DIPRODUKSI DARI KOMBINASI GELATIN KULIT KAKI AYAM DAN SOY PROTEIN ISOLATE ». Buletin Peternakan 35, n^o 3 (27 septembre 2012) : 188. http://dx.doi.org/10.21059/buletinpeternak.v35i3.1092.

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Penelitian bertujuan memanfaatkan gelatin kulit kaki ayam yang dikombinasikan dengan soy protein isolate sebagai bahan baku edible film. Materi penelitian adalah gelatin kulit kaki ayam dan soy protein isolate. Penelitian terbagi atas dua tahap yaitu tahap pertama adalah pembuatan gelatin kulit kaki ayam yang direndam dengan NaOH 0,1%, asam sulfat 0,1%, dan asam sitrat 0,4%. Tahap kedua yaitu pembuatan edible film yang dikombinasikan dengan soy protein isolate pada perbandingan (75:25, 80:20, 85:15, 90:10, dan 95:5). Analisis data mengunakan variansi pola searah, apabila terdapat beda nyata diteruskan uji Duncan’s New Multiple Range Test. Profil protein dianalisis dengan SDS-PAGE dan menunjukkan sebagai molekul kolagen. Hasil analisis kandungan asam amino edible film menggunakan HPLC dihasilkan komposisi residu asam amino terbesar adalah glysin yaitu 29,42%, 37,88%, 38,32%, 39,28% dan 39,17% pada masing-masing perlakuan. Hal itu menggambarkan bahwa profil protein edible film dapat dipastikan sebagian besar berasal dari kolagen gelatin. Pengamatan dengan scaning electron microscope menunjukkan telah terbentuk cross linking antara molekul protein gelatin dan molekul soy protein isolate dan yang ditunjukan semakin berkurangnya retakan seiring dengan meningkatnya konsentrasi gelatin. Perbedaan kombinasi gelatin kulit kaki ayam dan soy protein isolate untuk membentuk edible film tidak memberikan pengaruh nyata pada kekuatan tarik (tensile strenght), dan kemuluran (elongation), namun berpengaruh nyata pada laju transmisi uap air (Water Vapour Transmision Rate). Kombinasi 95:5 protein gelatin kulit kaki ayam dan soy protein isolate menghasilkan edible film yang terbaik. (Kata kunci: Edible film, Gelatin kaki ayam, Soy protein isolate)

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Raudina, Anggit Sapta, Sri Redjeki et Nur Taufiq-Spj. « Biodiversitas dan Tingkah Laku Kemunculan Cetacea di Perairan Laut Sawu, Nusa Tenggara Timur ». Journal of Marine Research 10, n^o 4 (14 octobre 2021) : 453–62. http://dx.doi.org/10.14710/jmr.v10i4.30433.

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Perairan Indonesia memiliki lebih dari sepertiga jenis paus dan lumba-lumba dunia, termasuk juga beberapa jenis yang dikategorikan langka dan terancam punah. Beberapa jenis Cetacea yang menggunakan jalur migrasi melalui perairan Indonesia bagian Timur, antara lain Samudera Hindia dan Pasifik melalui perairan Kepulauan Komodo, Solor-Lembata (NTT), Laut Banda (Maluku), Sulawesi Tenggara, Sulawesi Utara dan Sorong-Fakfak (Papua). Hal ini menunjukkan bahwa Laut Sawu merupakan area pengasuhan dan mencari makan paus. Laut Sawu menjadi tempat potensial karena dijadikan jalur migrasi berbagai spesies Cetacea secara rutin. Sehingga penelitian ini bertujuan untuk menganalisa keanekaragaman dan tingkah laku Cetacea yang bermigrasi. Penelitian ini dilakukan pada bulan November 2018 di perairan sekitar Teluk Kupang dan Sulamu dengan menggunakan metode pengamatan single platform yang telah dimodifikasi. Data diolah melalui aplikasi ArcGIS 10.4 dan Microsoft Office Excel. Hasil penelitian menunjukkan bahwa jumlah kemunculan Cetacea berbeda-beda tiap spesiesnya dengan total 114 kali kemunculan. Aktivitas yang dilakukan Cetacea saat kemunculan sangat beragam, namun yang paling banyak yaitu aerials dan bowriding dari jenis lumba-lumba, kemudian logging dan spyhopping dari jenis paus. Dari data ini dapat disimpulkan bahwa, lumba-lumba mempunyai kebiasaan untuk cenderung bermigrasi dalam satu kelompok besar. Sehingga kemunculan lumba-lumba sangat mendominasi di perairan Laut Sawu dibanding kemunculan paus yang cenderung soliter maupun dalam kelompok lebih kecil. More than one third of the world's whales and dolphins are found in Indonesian waters, including several that are categorized as rare and endangered species. Several types of cetaceans - migrate use eastern part of Indonesian waters as a migration route, i.e. between the Indian and Pacific Oceans through the waters of the Komodo Islands, Solor-Lembata (NTT), Banda Sea (Maluku), Southeast Sulawesi, North Sulawesi and Sorong-Fakfak (Papua). This indicated that the Savu Sea is a region for whales feeding ground and for their breeding.Apart from being a potential place for the Savu Sea to be used as a regular migration route for various cetacean species, it also has very promising tourism potential. Other than that, Migratory cetacean species are also very diverse, so this research was aims to analyze the diversity and behavior of cetaceans that migrate every year. This research was done in November 2018 around the Bay of Kupang and Sulamu, and a modified single platform observation method was used. The data were processed through the ArcGIS 10.4 and Microsoft Office Excel. The result shows that the occurrence number of cetaceans was in different species with a total of 114 appearances. The activities carried out by cetaceans at the time of emergence were varied, but the most common were aerials and bow-riding by dolphins, then logging and spyhopping by whales. Dolphins themselves are animals that tend to group in one large group so that their appearance is very dominant compared to whales which tend to be solitary and aggregated in small groups.

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Mevada, Surekha Tony, Abdaluziz Sulieman AlDhuli, A. Hakim Al-Rawas, Murtadha K. Al-Khabori, Hanan Nazir, Mathew Zachariah et Prof Yasser Wali. « Liver Enzymes Changes and Safety Profile of Deferasirox Iron Chelator in Omani Children with Thalassemia Major ». Blood 124, n^o 21 (6 décembre 2014) : 4903. http://dx.doi.org/10.1182/blood.v124.21.4903.4903.

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Abstract Background: Iron overload is a leading cause of morbidity and mortality in beta thalassemia and chelation therapy remains the mainstay in reducing iron burden. For effective chelation, optimal drug dosage with close monitoring of side effects is crucial. The safety and efficacy of deferasirox has been extensively studied in adult population. We aimed at evaluating the liver enzyme changes and safety profile of deferasirox in pediatric patients with thalassemia major. Materials and Methods: A retrospective study of 30 patients (range 2-15 years) with thalassemia major on regular follow up at the Pediatric Day care Center, Sultan Qaboos University Hospital was performed to evaluate the side effects of deferasirox over a mean of 15 month follow-up period. Data from electronic patients' records was collected for age, gender, serum ferritin, alanine transaminase, (ALT), aspartate transaminase (AST), dose and side effects of deferasirox. Data were analyzed using SPSS software version 19. Results: Thirteen (44.8 %) patients had either ALT or AST elevation above 2 times upper limit of normal (ULN). Except for two (6.8%) patients with enzyme elevations more than 5 times ULN, the majority of patients had mild transaminitis. None of the patients had liver enzyme elevation above 10 times ULN. The other side effects included fever (17.24%), nausea and vomiting (10.34% each), diarrhoea (13.79%), skin rash (21.4%), elevated serum creatinine with either 2 consecutive readings more than 33% of baseline level and/or single reading above 60% baseline (17.24%). The mean serum ferritin dropped from initial baseline level of 1236.21 ± 354 ng/ml (Range 534 -2821 ng/ml) to a level of 950 ± 320 ng/ml (Range 550-1900 ng/ml) at the end of the study period; with a mean deferasirox dose of 32.72 ± 4.79 mg/kg/day. Conclusion: Majority of our patients had mild transaminitis not requiring dose modification or interruption of chelation. Patients with significant elevations of liver enzymes more than 5 times ULN showed prompt recovery of transaminitis within 4-5 weeks of dose reduction of deferasirox by 5 mg/kg/day and future dose increments were well tolerated. Except for significant elevations in serum creatinine requiring dose reduction or short interruption, the other adverse events were well tolerated and did not warrant dose modification. Deferasirox was effective in reducing serum ferritin levels and was well tolerated in our young patients with thalassemia major. Table 1 PatientCharacteristics Numberof patients, n 30 Meanage of patients, years Range,years 7.24± 3.4 2-15 Meanserum ferritin, ng/ml Range,ng/ml 1236.21± 354 534-2821 Meandose of deferasirox (mg/kg/day) 32.72± 4.79 Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.

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Safitri, Rini, Kobajashi Togo Isamu et Nur Illiyin Akib. « UJI KUALITAS GELATIN DARI TULANG IKAN TUNA SIRIP KUNING (Thunnus albacares) MENGGUNAKAN JENIS ASAM YANG BERBEDA ». Jurnal Fish Protech 2, n^o 2 (31 octobre 2019) : 218. http://dx.doi.org/10.33772/jfp.v2i2.9351.

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ABSTRACT The Aim of this study was to determine the quality of gelatin from the yellowfin tuna bone of different acid types and to know the effect of the use of acid as an extraction material to the quality of the yellowfin tuna gelatin. This study uses a variety of different acid concentrations, namely the solution of hydrochloric acid 4% (A1), acetate 4% acid (A2) and 4% sulphuric acid (A3). The study made use of the complete random draft (RAL) consisting of 3 treatments and 3 times repeated. Data on the observation result is analyzed using ANOVA (Analysis of Variance) at 95%, if there is a real difference (P > 0.05) then the test is carried out with a test of DMRT (Duncan Multiple Range Test) in the real standard 95%. Analysis of sensory testing, proximate composition, pH value tests, and lowliness. The highest consecutive sensory values (aroma and color) are found in the treatment of (A1) and (A3) with a value of 6.2 and 6.1. The highest consecutive proximate composition values (moisture content, ash content, and protein levels) are noted in the (A2) and (A1) treatments with values of 12.51, 6.60 and 50.64. Highest pH value on the treatment of (A1) and (A2) with value 5. The highest yield values in the (A3) treatment with a value of 3%. From statistics of real difference test (DMRT) indicates that there is no noticeable difference in the gelatin color and aroma of the yellowfin Tuna fish bones by using altered acid types. Keywords: Gelatin, Lowliness, Proximate, PH value, sensory test, Tuna bone, and ABSTRAKPenelitian ini bertujuan untuk mengetahui kualitas gelatin dari tulang ikan tuna sirip kuning dari jenis asam yang berbeda dan untuk mengetahui pengaruh penggunaan asam sebagai bahan pengekstraksi terhadap kualitas gelatin ikan tuna sirip kuning. Penelitian ini menggunakan variasi konsetrasi asam yang berbeda yaitu larutan asam klorida 4% (A1), asam asetat4% (A2) dan asam sulfat 4% (A3). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan dan 3 kali ulangan. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (P>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Analisis uji sensori, komposisi proksimat, uji nilai pH dan rendemen. Nilai sensori tertinggi berturut-turut (aroma dan warna) terdapat pada perlakuan (A1) dan (A3) dengan nilai 6.2 dan 6.1. Nilai komposisi proksimat berturut-turut tertinggi (kadar air, kadar abu, dan kadar protein) terdapat pada perlakuan (A2) dan (A1) dengan nilai 12.51, 6.60 dan 50.64. Nilai pH tertinggi pada perlakuan (A1) dan (A2) dengan nilai 5. Nilai rendemen tertinggi pada perlakuan (A3) dengan nilai 3%. Dari statistik uji beda nyata (DMRT) menunjukkan bahwa tidak terdapat perbedaan nyata pada warna dan aroma gelatin dari tulang ikan Tuna sirip kuning dengan menggunakan jenis asam yang berbeda.Kata kunci: Gelatin, Nilai pH,Proksimat, Rendemen, Tulang Ikan Tuna, dan Uji Sensori

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Safitri, Rini, Kobajashi Togo Isamu et Nur Illiyin Akib. « UJI KUALITAS GELATIN DARI TULANG IKAN TUNA SIRIP KUNING (Thunnus albacares) MENGGUNAKAN JENIS ASAM YANG BERBEDA ». Jurnal Fish Protech 2, n^o 2 (31 octobre 2019) : 218. http://dx.doi.org/10.33772/jfp.v2i2.9351.

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ABSTRACT The Aim of this study was to determine the quality of gelatin from the yellowfin tuna bone of different acid types and to know the effect of the use of acid as an extraction material to the quality of the yellowfin tuna gelatin. This study uses a variety of different acid concentrations, namely the solution of hydrochloric acid 4% (A1), acetate 4% acid (A2) and 4% sulphuric acid (A3). The study made use of the complete random draft (RAL) consisting of 3 treatments and 3 times repeated. Data on the observation result is analyzed using ANOVA (Analysis of Variance) at 95%, if there is a real difference (P > 0.05) then the test is carried out with a test of DMRT (Duncan Multiple Range Test) in the real standard 95%. Analysis of sensory testing, proximate composition, pH value tests, and lowliness. The highest consecutive sensory values (aroma and color) are found in the treatment of (A1) and (A3) with a value of 6.2 and 6.1. The highest consecutive proximate composition values (moisture content, ash content, and protein levels) are noted in the (A2) and (A1) treatments with values of 12.51, 6.60 and 50.64. Highest pH value on the treatment of (A1) and (A2) with value 5. The highest yield values in the (A3) treatment with a value of 3%. From statistics of real difference test (DMRT) indicates that there is no noticeable difference in the gelatin color and aroma of the yellowfin Tuna fish bones by using altered acid types. Keywords: Gelatin, Lowliness, Proximate, PH value, sensory test, Tuna bone, and ABSTRAKPenelitian ini bertujuan untuk mengetahui kualitas gelatin dari tulang ikan tuna sirip kuning dari jenis asam yang berbeda dan untuk mengetahui pengaruh penggunaan asam sebagai bahan pengekstraksi terhadap kualitas gelatin ikan tuna sirip kuning. Penelitian ini menggunakan variasi konsetrasi asam yang berbeda yaitu larutan asam klorida 4% (A1), asam asetat4% (A2) dan asam sulfat 4% (A3). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan dan 3 kali ulangan. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (P>0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Analisis uji sensori, komposisi proksimat, uji nilai pH dan rendemen. Nilai sensori tertinggi berturut-turut (aroma dan warna) terdapat pada perlakuan (A1) dan (A3) dengan nilai 6.2 dan 6.1. Nilai komposisi proksimat berturut-turut tertinggi (kadar air, kadar abu, dan kadar protein) terdapat pada perlakuan (A2) dan (A1) dengan nilai 12.51, 6.60 dan 50.64. Nilai pH tertinggi pada perlakuan (A1) dan (A2) dengan nilai 5. Nilai rendemen tertinggi pada perlakuan (A3) dengan nilai 3%. Dari statistik uji beda nyata (DMRT) menunjukkan bahwa tidak terdapat perbedaan nyata pada warna dan aroma gelatin dari tulang ikan Tuna sirip kuning dengan menggunakan jenis asam yang berbeda.Kata kunci: Gelatin, Nilai pH,Proksimat, Rendemen, Tulang Ikan Tuna, dan Uji Sensori

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Dispenzieri, Angela, Thomas E. Witzig, Martha Q. Lacy, Susan M. Geyer, Teresa Kimlinger, S. Vincent Rajkumar, Philip R. Greipp et al. « A Phase II Trial of Gleevec™ in Patients with Refractory/Relapsed Myeloma. » Blood 104, n^o 11 (16 novembre 2004) : 2420. http://dx.doi.org/10.1182/blood.v104.11.2420.2420.

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Abstract Background: Though STI-571 (Gleevec™) was designed to specifically inhibit the bcr-abl gene product, it inhibits other receptor tyrosine kinases at physiologically attainable concentrations, including c-kit (steel factor receptor, stem cell factor receptor, SCF-R or CD 117). Studies have shown that about one-third of patients with multiple myeloma or monoclonal gammopathy of undetermined significance have plasma cells that display reactivity for c-kit. Others have shown that several myeloma cell lines and fresh myeloma bone marrow cells proliferate in response to stem cell factor. mRNA transcripts for c-kit ligand and, more commonly, its receptor have been detected in myeloma cell lines RPMI 8226, JJN3, U266 B1, NCI-H929, ARH77 and HS-Sultan by RT-PCR. Methods: Patients were eligible for study if they presented with relapsed or refractory myeloma, an ECOG performance score < 3, ability to sign informed consent, serum creatinine <3.5 mg/dL, direct bilirubin <2 mg/dL, alkaline phosphatase <750 U/L, absolute neutrophil count > .5 x 10(9)/L and platelet count > 50 x 10(9)/L. Patients were treated with Gleevec™ 400 mg po qd. The purpose of the study was to assess the response rate of the drug Gleevec™ in patients with relapsed multiple myeloma. Secondary objectives included assessment of the tolerability of the regimen in this cohort of patients and to correlation between disease response and c-kit positivity (CD117) by flow cytometry. Results: Overall, 23 patients were enrolled between 12/01 and 11/02, of which 16 were male and 12 had a prior PBSCT. Median age was 63 years (range: 49 – 82), and the baseline performance scores were 0 (8 patients), 1 (10), and 2 (4). Median time from MM diagnosis to enrollment was 57 months (range: 11 – 133). Patients were high risk with a median PCLI of 1.3 (range: 0 – 23%) and a median beta-2 microglobulin of 4.6 (range: 1.4 – 10.1). Eleven of 21 tested patients had positive CD117 (≥20%) staining of their bone marrow plasma cells by flow cytometry. None were PDGF positive. The treatment was well tolerated. After treatment with Gleevec™, there were only 3 non-hematologic grade 3 or 4 toxicities, and they occurred in 1 patient: he developed a capillary leak type syndrome, ascites, and dyspnea as part of his terminal phase of myeloma which included evolution into plasma cell leukemia. Grade 3 myelosuppression was observed in a minority of patients: thrombocytopenia (3), neutropenia (1), and anemia (3). There were no responses, and no patients are currently receiving treatment. Patients ended treatment due to progressive disease (18 patients), death on study (3), adverse reactions (1), and other reasons (1). The median duration of treatment was 48 days (range: 12 to 349). Of the 7 patients who remained on study for more than 60 days, CD117 status was as follows: positive (4); negative (3); not ascertained (1). As of August 2004, 12 patients have died. Conclusions: Though forty-eight percent of the enrolled myeloma patients were CD117 positive, providing a putative target for the Gleevec™, no responses were seen in this high risk population of relapsed patients. Further study will be necessary to determine the significance of the observed stabilization of disease in 36% of the CD117 positive patients.

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Farida, Farida, Kobajashi Togo Isamu et Nur Illiyin Akib. « KARAKTERISTIK GELATIN BERBAHAN BAKU TULANG IKAN CAKALANG (Katsuwonus pelamis) DENGAN MENGGUNAKAN JENIS ASAM YANG BERBEDA ». Jurnal Fish Protech 3, n^o 1 (29 mars 2020) : 79. http://dx.doi.org/10.33772/jfp.v3i1.11608.

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Characteristics of gelatin made from skipjack fish (Katsuwonus pelamis) using different types of acidsABSTRACT The aim of this study was to determine the gelatin processing technique using different types of acids and the effect of the use of acid as an extracting agent on the gelatin quality of skipjack fish bones. This study used a Completely Randomized Design (CRD) consisting of 3 treatments, namely A1 (immersion with 4% HCl), A2 (immersion with 4% CH3COOH) and A3 (immersion with 4% H2SO4). Each treatment was carried out 3 times so that the number of experimental units was 9 units. Data from observations were analyzed using ANOVA (Analysis of Variance) at a level of 95%, if there was a significant difference (p <0.05), further tests were carried out with the DMRT (Duncan Multiple Range Test) tests at a 95% significance level. The results obtained showed that the characteristics of gelatin made from skipjack fish bones by using a different type of acid did not have a significant effect on sensory values which included color and aroma. The best results for sensory assessment of the immersion using sulfuric acid were 6.2 and the aroma sensory test with immersion using hydrochloric acid was 5.4. The results of gelatin proximate showed that the water content ranged from 3.99% -13.32% ash content 2.27-3.19% protein content 27.08% -35.42% and pH 2.93% -4.81%.Keywords: gelatin, skipjack fish, hydrochloric acid, sulfuric acid and acetic acid ABSTRAKTujuan penelitian ini adalah untuk mengetahui teknik pengolahan gelatin dengan menggunakan jenis asam yang berbeda dan pengaruh penggunaan asam sebagai bahan pengestrak terhadap kualitas gelatin tulang ikan cakalang. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan yaitu A1 (perendaman dengan HCl 4%), A2 (perendaman dengan CH3COOH 4%) dan A3 (perendaman dengan H2SO4 4%). Masing-masing perlakuan dilakukan 3 kali ulangan, sehingga diperoleh jumlah satuan percobaan sebanyak 9 unit. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (p<0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Hasil penelitian yang diperoleh menunjukkan bahwa karakteristik gelatin berbahan baku tulang ikan cakalang dengan menggunakan jenis asam yang berbeda tidak memberikan pengaruh nyata terhadap nilai sensori yang meliputi warna dan aroma. Hasil terbaik untuk penilaian sensori terhadap pada perendaman menggunakan asam sulfat yaitu 6,2 dan uji sensori aroma dengan perendaman menggunakan asam klorida yaitu 5,4. Hasil proksimat gelatin menunjukkan kadar air berkisar antara 3,99%-13,32% kadar abu 2,27-3,19% kadar protein 27,08%-35,42% dan pH 2,93%-4,81%.Kata kunci: gelatin, tulang ikan, HCl, H2SO4, CH3COOH

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Farida, Farida, Kobajashi Togo Isamu et Nur Illiyin Akib. « KARAKTERISTIK GELATIN BERBAHAN BAKU TULANG IKAN CAKALANG (Katsuwonus pelamis) DENGAN MENGGUNAKAN JENIS ASAM YANG BERBEDA ». Jurnal Fish Protech 3, n^o 1 (29 mars 2020) : 79. http://dx.doi.org/10.33772/jfp.v3i1.11608.

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Characteristics of gelatin made from skipjack fish (Katsuwonus pelamis) using different types of acidsABSTRACT The aim of this study was to determine the gelatin processing technique using different types of acids and the effect of the use of acid as an extracting agent on the gelatin quality of skipjack fish bones. This study used a Completely Randomized Design (CRD) consisting of 3 treatments, namely A1 (immersion with 4% HCl), A2 (immersion with 4% CH3COOH) and A3 (immersion with 4% H2SO4). Each treatment was carried out 3 times so that the number of experimental units was 9 units. Data from observations were analyzed using ANOVA (Analysis of Variance) at a level of 95%, if there was a significant difference (p <0.05), further tests were carried out with the DMRT (Duncan Multiple Range Test) tests at a 95% significance level. The results obtained showed that the characteristics of gelatin made from skipjack fish bones by using a different type of acid did not have a significant effect on sensory values which included color and aroma. The best results for sensory assessment of the immersion using sulfuric acid were 6.2 and the aroma sensory test with immersion using hydrochloric acid was 5.4. The results of gelatin proximate showed that the water content ranged from 3.99% -13.32% ash content 2.27-3.19% protein content 27.08% -35.42% and pH 2.93% -4.81%.Keywords: gelatin, skipjack fish, hydrochloric acid, sulfuric acid and acetic acid ABSTRAKTujuan penelitian ini adalah untuk mengetahui teknik pengolahan gelatin dengan menggunakan jenis asam yang berbeda dan pengaruh penggunaan asam sebagai bahan pengestrak terhadap kualitas gelatin tulang ikan cakalang. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan yaitu A1 (perendaman dengan HCl 4%), A2 (perendaman dengan CH3COOH 4%) dan A3 (perendaman dengan H2SO4 4%). Masing-masing perlakuan dilakukan 3 kali ulangan, sehingga diperoleh jumlah satuan percobaan sebanyak 9 unit. Data hasil pengamatan dianalisa menggunakan ANOVA (Analysis of Variance) pada taraf 95%, apabila terdapat beda nyata (p<0,05) maka dilakukan uji lanjut dengan uji DMRT (Duncan Multiple Range Test) pada taraf nyata 95%. Hasil penelitian yang diperoleh menunjukkan bahwa karakteristik gelatin berbahan baku tulang ikan cakalang dengan menggunakan jenis asam yang berbeda tidak memberikan pengaruh nyata terhadap nilai sensori yang meliputi warna dan aroma. Hasil terbaik untuk penilaian sensori terhadap pada perendaman menggunakan asam sulfat yaitu 6,2 dan uji sensori aroma dengan perendaman menggunakan asam klorida yaitu 5,4. Hasil proksimat gelatin menunjukkan kadar air berkisar antara 3,99%-13,32% kadar abu 2,27-3,19% kadar protein 27,08%-35,42% dan pH 2,93%-4,81%.Kata kunci: gelatin, tulang ikan, HCl, H2SO4, CH3COOH

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H. Cahyana, Gede, Gilang Gumilar et Tri Mulyani. « Pengolahan Air Limbah Betalaktam Menggunakan Reagen Kaporit, PAC, dan Alum Sulfat ». Jurnal Serambi Engineering 6, n^o 3 (29 juin 2021). http://dx.doi.org/10.32672/jse.v6i3.3118.

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Beta lactam antibiotics are pollutant in water bodies such as lakes and rivers. Beta lactam rings may have a negative impact on living beings in lakes and rivers. Beta lactam rings also cause resistance or bacterial resistance to antibiotics. If human beings are exposed to beta lactam ring, this could negatively impact on their health. This study attempted to break down the beta lactam rings with several chemical reagents. These reagents hydrolyze the beta lactam ring and are then analyzed using the HPLC (High Performance Liquid Chromatography) instrument. This study aims to determine the how effective the reagent for breaking the beta lactam ring. The research was conducted in three stages: preliminary research, research on reagent effectiveness , and research on β-lactamase degradation using reagents. The results showed that calcium hypochlorite was able to break the beta lactam cycle with 100% efficiency.

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Zholdybayeva, Elena, Saniya Kozhakhmetova, Sabina Atavliyeva, Pavel Tarlykov et Yerlan Ramankulov. « Draft Genome Sequence of a Bacteroides fragilis Strain Isolated from Peritoneal Fluid of a Patient from Kazakhstan ». Microbiology Resource Announcements 9, n^o 26 (25 juin 2020). http://dx.doi.org/10.1128/mra.00377-20.

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ABSTRACT Here, we report the draft genome sequence of Bacteroides fragilis strain KZ02, isolated from a patient with peritonitis hospitalized in a health facility in Nur-Sultan, Kazakhstan. The genome of the strain contains 4,103 protein-coding genes, including the cepA gene, which causes resistance to beta-lactam antibiotics.

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Al-Saadi, Tariq Dhiyab, Al-Salt Al-Kharusi et Ali Abdulrahman. « Utilization of Beta-Blockers and Diuretics in Treating Heart Failure Patients in Sultan Qaboos University Hospital ». European Journal of Medical and Health Sciences 2, n^o 2 (21 avril 2020). http://dx.doi.org/10.24018/ejmed.2020.2.2.234.

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Background: Heart failure (HF) is the inability of the heart to pump blood to meet tissue requirement of oxygen and nutrition, due to abnormality in cardiac structure or function. The mortality from congestive heart failure remain increasing along with aging of the population. In Oman, the prevalence of HF is 5.17 per 1000 people and with male and older age group domination. Beta-blockers and diuretics are well known drugs that decrease mortality and morbidity. According to heart failure treating guidelines beta-blockers are the first line treatment for HF. Since HF has a high prevalence, this study aim was to determine the utilization of beta-blockers and diuretics in treating heart failure patients in Sultan Qaboos University Hospital (SQUH). Methods: A retrospective cross-sectional conducted in SQUH, in cardiology day care clinic in the period from 1st of June until 30th of August. This study included all Omani patients with 120 out of 778 patients were included who were above 18 years old, diagnosed with HF, receiving at least one HF medication from SQUH pharmacy, and did not have any missing data. Hospital electronic medical record was used to obtain patients data and parameters. Results: Out of 120 patients, 54.2% were males and 45.8% were females, with mean age equal to 64 ± 13 years and mean EF equal to 37 ± 14.5 %. Diuretics were taken by 95% of the patients, where beta-blockers were taken by 81.6%. Prescription of beta-blockers was significantly decreased by increase in the age of the patients (p =0.024), while diuretics do not show any significant with change in the age. Both beta-blockers and diuretics do not show any significant increase or decrease in prescription with change in the EF. Bisoprolol was not affected by increase in age or EF. The prescription of carvedilol was significantly affected with increase the age (p = 0.006), however it was not affected by increase the EF. The prescription of spironolactone was significantly affected by increase the age (P= 0.001) and by increase the EF (P = 0.001). Conclusion: Carvedilol and furosemide were the most prescribed drugs in SQUH for treating HF patients. All the mean daily doses of the drugs mentioned in this study followed the newer 2016 European Society of Cardiology Guidelines for the diagnosis and treatment of acute and chronic HF.

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Tajarian, Yvette. « The World Through the Lens of the Photographer Ara Güler ». Journal of Art Studies, 13 février 2023, 167–78. http://dx.doi.org/10.54503/2579-2830-2022.2(8)-167.

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The art of photography appeared in Turkey between the XIX and XX centuries. In the beginning, because of the high price of the service, only the rich could afford it. The first photography studio in the Ottoman Empire was established in the Bera district of Constantinople (presently, the Beyoglu district of Istanbul), where most of the population was Christian. Here, in 1857, Pascal Sebah of Armenian descent opened a photography center. He was one of the few to be awarded the Third-Class Order of the Medjidie by Sultan Abdulmejid. Unfortunately, all his photographic works were burnt in the great fire of 1881. The sons of Sarraf Mikayel Abdullahyan – Vichen, Gevorg and Hovsep Abdullah, also occupy an important place in the history of Turkish photography. They held a monopoly on dissemination of photography throughout the Empire. In 1836, the Abdullahyan brothers became special photographers fоr Sultan Abdul Aziz. In 1867, near the Russian Embassy in Bera, they opened a photography studio named “Abdullah Brothers”. A great number of photographers of Turkish and foreign descent, working in Turkey, namely, the Gulmez brothers, Ashil Samanj, Jerome Savajian, the Papazyan brothers, Antoine Zilipojian, Othmar Pfersci, Ismayin Nesmi, Ahmed Polat and others, furthered the development of Turkish photography. Ara Güler is one of those, who played a big part in the history of photography, having created with his outstanding works a whole new world in that field.

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Jonsson, B. A., G. Bjornsdottir, T. E. Thorgeirsson, L. M. Ellingsen, G. Bragi Walters, D. F. Gudbjartsson, H. Stefansson, K. Stefansson et M. O. Ulfarsson. « Brain age prediction using deep learning uncovers associated sequence variants ». Nature Communications 10, n^o 1 (27 novembre 2019). http://dx.doi.org/10.1038/s41467-019-13163-9.

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AbstractMachine learning algorithms can be trained to estimate age from brain structural MRI. The difference between an individual’s predicted and chronological age, predicted age difference (PAD), is a phenotype of relevance to aging and brain disease. Here, we present a new deep learning approach to predict brain age from a T1-weighted MRI. The method was trained on a dataset of healthy Icelanders and tested on two datasets, IXI and UK Biobank, utilizing transfer learning to improve accuracy on new sites. A genome-wide association study (GWAS) of PAD in the UK Biobank data (discovery set: $$N=12378$$N=12378, replication set: $$N=4456$$N=4456) yielded two sequence variants, rs1452628-T ($$\beta =-0.08$$β=−0.08, $$P=1.15\times{10}^{-9}$$P=1.15×10−9) and rs2435204-G ($$\beta =0.102$$β=0.102, $$P=9.73\times 1{0}^{-12}$$P=9.73×10−12). The former is near KCNK2 and correlates with reduced sulcal width, whereas the latter correlates with reduced white matter surface area and tags a well-known inversion at 17q21.31 (H2).

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El-Mouhamady, Almoataz Bellah Ali, Magdy Ahmad Al-Kordy et Tarik Abdel-Fatah Elewa. « Elucidation of genetic diversity among some accessions of sugar beet (Beta vulgaris L.) using inter-simple sequence repeats (ISSR) markers ». Bulletin of the National Research Centre 45, n^o 1 (9 octobre 2021). http://dx.doi.org/10.1186/s42269-021-00625-8.

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Abstract Background Sugar beet is considered a very important strategic economic crop, as it comes at the second place for white sugar production in Egypt after sugar cane and the sugar percentage in its roots is 20%. This work was conducted in Egypt as a direct response to bridge the gap which began to expand significantly between the production and consumption of white sugar and the desire for the genetic improvement process to increase the productivity of this crop. Further, as serious attempt to understand the nature of the genetic diversity among a group of sugar beet accessions with different origins, it constitutes an important source for establishing a program of breeding and improving sugar beet crop under Egyptian conditions. Results The process of verifying the existence of significant genetic variation between the eight sugar beet varieties with various origins was carried out through a set of genetic parameters through two growing seasons besides, the data of ISSR markers profile. Further, all the sugar beet varieties were superior in all the studied traits during their evaluation over two agricultural years, where the two sugar beet accessions Oscar Poly and Rass Poly are superior in TSS % and sucrose % traits, Mont Bianco and Sultan in apparent purity % trait, Blino and Sultan in root yield and top yield traits and Rass Poly and Blino in sugar yield trait, respectively. In addition, the values of heritability in broad sense were high in all studied traits except the two traits; sucrose % and sugar yield where their results were appeared medium during both growing seasons. In the same regard, expected genetic advance values showed significant genetic progress in all studied traits during the two growing seasons. As well, highly genetic diversity was obtained between the eight sugar beet accessions through generated 169 amplified fragments from the twelve ISSR primers, 122 of them were polymorphic with 72.18% polymorphism. Conclusions The eight sugar beet varieties achieved remarkable and distinctive results for all traits under study during two agricultural years. However, they were differentiated and various from each other. As they differed in their superiority in all estimated traits and they proved to be fertile material for studying in this investigation and very suitable for enriching the breeding and genetic improvement program to promote the sugar beet yield in order to increase the productivity of white sugar in Egypt.

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Ichimata, Shojiro, Ain Kim, Naoki Nishida et Gabor G. Kovacs. « Lack of difference between amyloid‐beta burden at gyral crests and sulcal depths in diverse neurodegenerative diseases ». Neuropathology and Applied Neurobiology, 17 décembre 2022. http://dx.doi.org/10.1111/nan.12869.

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Purwanti, Ika. « Faktor-faktor yang Mempengaruhi Kualitas Bakteriologis Air Bersih pada Sumur Gali ». Jurnal Ilmiah WUNY 16, n^o 3 (9 février 2015). http://dx.doi.org/10.21831/jwuny.v16i3.2964.

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Air bersih sangat bermanfaat bagi kehidupan manusia antara lain untuk air minum, memasak, mandi, mencuci dan lain-lain. Air bersih merupakan air yang dapat digunakan untuk keperluan sehari-hari yang kualitasnya memenuhi syarat kesehatan dan dapat diminum apabila telah dimasak. Air yang sehat, yaitu air yang bebas dari organisme penyebab penyakit dan bahan kimia beracun. Syarat-syarat kualitas air bersih meliputi syarat bakteriologis, fisika, kimia, dan radioaktif. Syarat fisik meliputi bau, warna, suhu, kekeruhan, dan zat terlarut (TDS atau Total Dissolved Solid). Syarat kimia meliputi pH, kesadahan (CaCO3 ), nitrit, nitrat, amoniak, fluorida, sulfat, zat organik dan logam-logam seperti besi, zink, merkuri, timbal, dan lain-lain. Syarat bakteriologis meliputi total coliform dan coliform tinja. Syarat radioaktif meliputi aktivitas Alfa dan Beta.

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