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Hansen, Rachel Lindsey. « A LOOK AT THE BAN THE BOX MOVEMENT IN LOCAL GOVERNMENT ». Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/612961.
Texte intégralDahlqvist, Sofia, et Marie Hedén. « Designens betydelse vid val av boxvin : En studie om konsumenters preferenser av designfaktorer på bag-in-box-vin ». Thesis, Högskolan Dalarna, Grafisk teknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:du-20826.
Texte intégralIn the Swedish market the bag-in-box wine stands for over 50 percent of all wine that sells and Sweden is the country where the bag-in-box have the strongest hold in the world (Fremin, 2012). This makes bag-in-box packaging a major and significant product for winemakers. Therefore having knowledge about selling design is important for graphic designers and other involved companies. This study included a visual content analysis of the bag-in-box wine in a liquor store in Sweden in order to get an overview of the supply. With the results, a web-based survey was created and implemented in the spring of 2015. The results showed that the majority of the respondents chose the wine based on the appearance of the package and felt that they were mainly effected by the colour, font, illustrations and brand. Consumers with higher knowledge about wine were less effected by the design in their choice of wine. Women and men had generally different opinions about how much impact the different design factors had in the choice of bag-in-box wine. This study is only a starting point for a subject that includes many influencing factors. Further research is therefore needed before completely truthful results can be established.
Mezentseva, Karyna. « Hydrology Of The Tamarack Bog, Bath Nature Preserve, Bath Township, Ohio ». University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1438166845.
Texte intégralOrtega, Felipe, et Berón Jesús. « Producción de bolsas con válvula tipo Bag in Box para la industria vitivinícola ». Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Aplicadas a la Industria, 2015. http://bdigital.uncu.edu.ar/7249.
Texte intégralFil: Ortega, Felipe. Universidad Nacional de Cuyo. Facultad de Ciencias Aplicadas a la Industria.
Fil: Berón Jesús. Universidad Nacional de Cuyo. Facultad de Ciencias Aplicadas a la Industria.
LaPlant, Eric G. « Racial Threat, Criminal History, and Employment : Examining the Determinants of Ban the Box Passage ». The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1466519138.
Texte intégralFlod, Jenny. « Utveckling av förpackning för livsmedelsrelaterade vätskor : Produktutvecklingsprojekt av ytterförpackning för vätskor med utgångspunkt i Bag-in-box konceptet ». Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-39146.
Texte intégralDenna rapport beskriver ett examensarbete där två prototyper på ytterförpackning för livsmedelsrelaterade vätskor är slutresultatet. Uppdraget sker i samarbete med design- och varumärkesbyrån Motherland och är ett examensarbete på högskoleingenjörsprogrammet i innovationsteknik och design på Karlstads universitet. Uppdragsgivaren vill ta fram en ny design på förpackning för vätskor där utgångsprodukten är Bag-in-box konceptet. Utgångsprodukten är bra i många avseenden, den är med sin blockformade konstruktion nästintill logistisk optimal för transport och lagring, har en enkel konstruktion, ger mindre negativ miljöpåverkan än både glas-, aluminium- och PET-flaskor och är billig att producera. Trots sin popularitet i så väl Sverige som övriga världen, visar förstudien att det är många brukare som anser att utgångsprodukten har sina brister. Många anser att förpackningen inte är tilltalande designmässigt, det är svårt att tömma på allt innehåll och att det är komplicerat då produkten skall elimineras. Att det endast doseras vid en bordskant är en annan nackdel. Målet med projektet är att med utgångspunkt i designprocessen gestalta och ge förslag på en eller flera prototyper på ytterförpackning där ny form och design står i fokus. Produkten måste vara lager och transportanpassad så att den tillgodoser krav på hållbar utveckling. Hänsyn skall tas till användarnas krav så att den/de nya produkterna tillgodoser brister hos utgångsprodukten. Förstudien gav insikt och kunskap om utgångskonceptet, fakta kring ett antal livsmedelsrelaterade vätskor, information om effektiva verktyg för idéutveckling, hållbar utveckling och tillvägagångssätt för tillverkning av en miljöanpassad förpackning. Fakta samlades in genom litteraturstudier, studiebesök, enkätundersökning, formstudier, komponentanalys och besök hos kunniga på relevanta områden. Förstudien resulterade i en kravspecifikation som användes som vägledning i produktutvecklingensprocessen. Projektet resulterade i två prototyper med samma konstruktionsdesign och volym men med olika dimensioner på höjd och bredd. De har en ny design och ett nytt tänk när det gäller utpumpningsfunktion dock har den samma slutfunktion som utgångsprodukten, skydda vätska, innehålla vätska, förflytta vätska och dosera vätska. De har ett öppnings- och återförslutningsbart lock som möjliggör för brukaren att kontrollera innehållet och underlättar för rätt källsortering. Lösningen gör att innerförpackningen lätt kan tas ur och på så sätt förenkla vid tömning av allt innehåll. Skissande och modellering har varit till stor hjälp i arbetet och framtagandet av slutresultatet.
Blomquist, Emil, et Trotte Boman. « The Dirac Equation for a Particle in a Spherical Box Potential with Application in Bag Modeling ». Thesis, KTH, Teoretisk fysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168309.
Texte intégralDirac-ekvationen är en relativistisk vågekvation och var den första ekvationen att inkludera spinn i relativistisk kvantmekanik. I vår rapport kommer Dirac-ekvationen att härledas och lösas för en partikel i en sfärisk lådpotential. Den kommer sedan att jämföras med den icke-relativistiska Schrödinger-ekvationen samt en relativistiskt korrigerad Schrödinger-ekvation. Några av Dirac-ekvationens användningsområden, såsom för Bogoliubovs modell, kommer att undersökas och diskuteras och det faktum att Diracekvationen kan ge oss information om hur elementära partiklar fungerar valideras.
Barrezueta, Luis Fernando Mesias [UNIFESP]. « Imuno-expressão das proteínas da família BCL-2 (BCL-2. BCL-XL, BAX, BAK, BAD) em câncer gátrico, preparados em arranjo em matriz (TMA) ». Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9724.
Texte intégralCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Em casos de carcinoma gástrico, para contribuir ao conhecimento do processo de carcinogênese: Objetivo: Estudar a expressão das proteínas da família Bcl-2 (BcI-2, Bcl-xl, Bak, Bad, Bax). Correlacionar a expressão destas proteínas com 0 índice apoptótico mediante a expressão da proteína Caspase 3 clivada, com 0 índice mit6tico mediante a expressão da proteína Ki-67 e com a expressão da proteína p53. Método: Técnica de arranjo em matriz de amostras teciduais (TMA): em 87 amostras de adenocarcinomas gástricos (grupo teste) e de mucosa gástrica não tumoral (grupo controle) foi avaliada a imuno-expressão das proteínas da família BcI-2 (BeI-2, Bcl-xl, Bak, Bad, Bax), da proteína p53, da proteína caspase 3 e da proteína Ki-67. Resultados: Todas as proteínas examinadas foram observadas nos adenocarcinomas e mucosa não tumoral, porem com diferenças de expressão em relação à porcentagem de positividade e intensidade. Observamos: i) Houve associação entre 0 tamanho do tumor e a proteína p53. ii) Houve associação da proteína Bad no adenocarcinoma com a idade dos pacientes. iii) Associação das proteínas Bax, Bad e Ki-67 com 0 adenocarcinoma de tipo intestinal. iv) As proteínas Bcl-xl, Bak, Bad, p53 e Ki-67 apresentaram diferenças estatisticamente significantes entre a imuno-expressão no tumor e na mucosa não tumoral. v) Associação das proteínas Bax, Bak e Bad na mucosa não tumoral. vi) Não houve correlação da imunoexpressão das proteínas com a sobrevida dos pacientes. Conclusão: A expressão aumentada da proteína Bcl-xl nos adenocarcinomas, com evidente diferença de expressão entre 0 grupo teste e 0 grupo controle, esta relacionada com 0 efeito anti-apoptótico da proteína. A expressão reduzida das proteínas Bak e Bad e a expressão aumentada das proteínas p53 e Ki-67 nos adenocarcinomas demonstram 0 desequilíbrio entre morte e proliferação celular, permitindo 0 crescimento descontrolado das células neoplásicas.
Purpose: To study the immunoexpression of Bcl-2 family proteins (Bcl-2, Bcl-xl, Bax, Bak, Bad) and to evaluate the correlation between the immunoexpression of these proteins with the cleaved caspases 3, Ki-67 and p53 immuno-expression. Methods: A TMA paraffin block was constructed with gastric carcinoma tissue (test group) and normal gastric adjoining mucosa (control group) of 87 patients. The TMA block was submitted to immunohistochemistry for Bcl-2, Bcl-xl, Bax, Bak, Bad, p53 and-cleaved Caspase 3. Results: All studied proteins were present in tumor and normal gastric adjoining mucosa, but with different intensity and amount of positive cells. i) There was an association between tumor size and p53 expression. ii) association between Bad expression in the tumor and patient’s age. iii) Intestinal type adenocarcinoma was positively correlated with the expression of Bax, Bad and Ki-67. iv) The protein Bcl-xl, Bak, Bad, p53 and Ki-67 showed statistically significant differences between the immuno-expression in tumor and normal gastric adjoining mucosa. v) There was an association between the proteins Bax, Bak and Bad expression in the normal gastric adjoining mucosa. vi) No correlation between patient’s survival rates and the expression of the proteins was observed. Conclusions: The higher expression of Bcl-xl protein in adenocarcinoma, the difference of Bcl-xl expression between test group and control group, might be related with the anti-apoptotic effect of this protein. The lower expression of Bak and Bad and the increased expression of p53 protein and Ki-67 protein in adenocarcinomas demonstrate the imbalance between death and cellular proliferation, which allows the uncontrolled tumor cell proliferation.
FAPESP: 04/09932-4
FAPESP: 06/54187-0
TEDE
Karch, Jason. « The Role of Bax and Bak in Necrotic Cell Death ». University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353099747.
Texte intégralCardoso, Claudio Fernandes. « Avaliação de um sistema asséptico para leite longa vida em embalagem flexível institucional do tipo bag-in-box ». [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254561.
Texte intégralTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: Esta pesquisa teve como objetivo avaliar o desempenho de um sistema asséptico piloto para a produção de leite UHT (Ultra Hight-Temperature), com capacidade de 1.000 L/h, em embalagens flexíveis institucionais do tipo Bag-in-box (BIB). As embalagens estudadas eram compostas de um filme de polietileno de baixa densidade (PEBD) e um filme de polietileno tereftalato metalizado (PETmet), com volume de 2.000 mL, desenvolvido especialmente para o envase asséptico de produtos lácteos. Leite cru refrigerado tipo A foi utilizado como matéria-prima. O envase do leite UHT foi realizado através de uma dosadeira semi-automática dentro de uma Sala Limpa ISO posicionada sobre o bocal de enchimento das embalagens. O sistema foi avaliado através da identificação e monitoramento de pontos de controle do processo, testes de esterilidade comercial, análises sensorial e físico-química do produto, bem como avaliações da embalagem. O desempenho das embalagens BIB foi avaliado através de ensaios de caracterização, integridade do sistema e estudos de estabilidade microbiana e testes de efetividade de esterilização. As embalagens foram esterilizadas com o uso de radiação ionizante (gama), com dose de 15 kGy. Os ensaios foram conduzidos através da produção de 4 lotes experimentais de leite UHT, obtido em trocador de calor a placas (140 °C por 5 s). A taxa de defeito encontrada nos testes de esterilidade comercial variou entre 0 e 6,7%, sendo que a principal causa de defeitos foi associada aos problemas inerentes a operacionalidade da linha, como falhas nas vedações das junções de tubulações e bombas centrífugas. Os resultados da avaliação dos pontos de controle do processo e embalagem indicaram um bom desempenho do sistema, justificado pela ausência de microorganismos viáveis. O leite UHT acondicionado nas embalagens BIB teve sua vida de prateleira estimada em até 27 semanas de estocagem, valor este muito superior quando comparado às amostras controle de leite UHT comercial, acondicionado em embalagens laminadas cartonadas, que teve sua vida de prateleira estimada em 19 semanas. A diferença de estabilidade físico-química, microbiológica e sensorial entre as amostras processadas e a comercial foi associada às propriedades de barreira das estruturas das embalagens à luz e ao oxigênio, bem como pela qualidade da matéria-prima utilizada. O sistema asséptico piloto avaliado correspondeu às expectativas de desempenho e atendeu aos requisitos estabelecidos pelo Codex Alimentarius. Concluiu-se que o sistema apresenta potencial para utilização por indústrias de laticínios visando atender o mercado institucional de leite longa vida
Abstract: The aim of this research was to evaluate the performance of an aseptic pilot system for the production of Ultra High Temperature (UHT) milk, with 1.000 L/h capacity, filled in flexible institutional packages Bag-in-box (BIB) type. The BIB packages were constructed with one layer of low density polyethylene film (LDPE) and another one of metalized polyethylene terephthalate film (PETmet), with 2.000 mL capacity, specially developed for the aseptic filling of dairy products. Type-A milk was used as raw material and the UHT milk filling was made by a semiautomatic machine located inside a ISO Clean room. The system was evaluated by the identification and monitoring of the control points during the process and also by commercial sterility tests, sensorial and physical-chemistry analysis and packages evaluations. The BIB packages were sterilized by gamma radiation with minimum doses of 15 kGy. The assays were conducted by the production of 4 experimental batches processed in a plate heat exchanger (140 °C/5 s). The defect rates founded were between 0 and 6.7% and these values can be explained by problems linked to the pilot plant operation, like failures in the connections of pipes and centrifugal pumps. The results of the control points evaluation and also BIB packages showed a good performance of the entire process, justified by the absence of viable microorganisms. The milk filled in BIB packages targeted until 27 weeks of shelf life, a superior value when it was compared to the commercial UHT samples, which targeted just 19 weeks. The difference of physical-chemistry, microbiology and sensory stability between the processed samples and the commercial one was associated to the oxygen and light barriers properties and also to the raw milk quality used during the processes. The pilot aseptic system evaluated attended to the Codex Alimentarius requirements and it could be concluded that the system showed potential for application in dairy industry in view of the long life milk institutional market
Doutorado
Tecnologia de Alimentos
Doutor em Tecnologia de Alimentos
Leshchiner, Elizaveta S. « Dissecting the Mechanisms of Direct Activation for Proapoptotic BAK and BAX ». Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10778.
Texte intégralMendes, Armando Monte. « Estudo da deposi??o de filmes finos de BaTi(1-X)Zr(X)O3 por meio de planejamento Box-Behnken ». Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20591.
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Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
Materiais cer?micos ferroel?tricos com estrutura perovskita (ABO3) s?o largamente utilizados em componentes de mem?ria no estado s?lido (FeRAM?s e DRAM?s) bem como em capacitores de m?ltiplas camadas, especialmente na forma de filmes finos. Quando dopados com ?ons de zirc?nio, materiais ? base de BaTiO3 formam uma solu??o s?lida conhecida como titanato zirconato de b?rio (BaTi1-xZrxO3). Tamb?m chamado de BZT, esse material pode sofrer significativas mudan?as em suas propriedades el?tricas diante de pequenas varia??es do teor de zirc?nio na rede cristalina. O presente trabalho consiste no estudo dos efeitos dos par?metros de deposi??o de filmes finos de BaTi0,75Zr0,25O3 pelo m?todo de spin-coating sobre sua morfologia e propriedades f?sicas, utilizando um planejamento experimental do tipo Box-Behnken. A resina utilizada no processo de deposi??o foi sintetizada pelo m?todo dos precursores polim?ricos (Pechini) e foi subsequentemente dividida em tr?s parcelas cada qual teve sua viscosidade ajustada para 10, 20 e 30 mPa?s por meio de um viscos?metro rotativo. As resinas foram depositadas em substratos de Pt/Ti/SiO2/Si pelo m?todo de spin-coating em 15 diferentes combina??es de viscosidade, velocidade de rota??o (3000, 5500 e 8000 rpm) e n?mero de camadas depositadas (5, 8 e 11 camadas) previstas no planejamento e ent?o calcinadas a 800?C por 1h. A fase cristalina dos filmes foi determinada por difra??o de Raios-X (DRX) e indexada com a carta JCPDS 36-0019. Morfologia da superf?cie e tamanho de gr?o foram observados por meio de microscopia de for?a at?mica (AFM) indicando filmes bem densificados e tamanho m?dio de gr?o em torno de 50nm. Imagens da se??o transversal dos filmes foram obtidas por interm?dio de microscopia eletr?nica de varredura com emiss?o de campo (MEV-FEG), indicando espessuras bem uniformes variando de 140-700 nm entre amostras. Medidas de capacit?ncia foram realizadas ? temperatura ambiente com a ajuda de um analisador de imped?ncia. Os filmes apresentaram valores de constante diel?trica de 49-277 a 100KHz e baixa perda diel?trica. O planejamento indicou efeitos n?o significativos das intera??es entre os par?metros de deposi??o sobre a espessura dos filmes. A metodologia de superf?cies de resposta possibilitou uma melhor observa??o dos efeitos das vari?veis.
Ferroelectric ceramics with perovskite structure (ABO3) are widely used in solid state memories (FeRAM?s and DRAM's) as well as multilayered capacitors, especially as a thin films. When doped with zirconium ions, BaTiO3-based materials form a solid solution known as barium zirconate titanate (BaTi1-xZrxO3). Also called BZT, this material can undergo significant changes in their electrical properties for a small variation of zirconium content in the crystal lattice. The present work is the study of the effects of deposition parameters of BaTi0,75Zr0,25O3 thin films by spin-coating method on their morphology and physical properties, through an experimental design of the Box-Behnken type. The resin used in the process has been synthesized by the polymeric precursor method (Pechini) and subsequently split into three portions each of which has its viscosity adjusted to 10, 20 and 30 mPa?s by means of a rotary viscometer. The resins were then deposited on Pt/Ti/SiO2/Si substrates by spin-coating method on 15 different combinations of viscosity, spin speed (3000, 5500 and 8000 rpm) and the number of deposited layers (5, 8 and 11 layers) and then calcined at 800 ? C for 1 h. The phase composition of the films was analyzed by X-ray diffraction (XRD) and indexed with the JCPDS 36-0019. Surface morphology and grain size were observed by atomic force microscopy (AFM) indicating uniform films and average grain size around 40 nm. Images of the cross section of the films were obtained by scanning electron microscopy field emission (SEM-FEG), indicating very uniform thicknesses ranging from 140-700 nm between samples. Capacitance measurements were performed at room temperature using an impedance analyzer. The films presented dielectric constant values of 55-305 at 100kHz and low dielectric loss. The design indicated no significant interaction effects between the deposition parameters on the thickness of the films. The response surface methodology enabled better observes the simultaneous effect of variables.
Vitali, Chiara. « Le bilinguisme au cinema : analyse du film < ; Bon Cop Bad Cop > ; ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14219/.
Texte intégralPalmer, Matthew Earle. « Kinematics of beam flexure four-bar linkages with applications in a compound bow ». Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-11012008-063505/.
Texte intégralMignard, Vincent. « Rôle des sphingolipides et des MAM dans l'activité des protéines pro-apoptotiques Bax et Bak ». Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=f5341358-f156-44f7-b830-9aa90095f905.
Texte intégralThe study of apoptosis is important to develop new anti-cancer strategies. The mitochondrial apoptotic pathway is tightly regulated by the interaction network of the Bcl-2 family proteins but other molecular actors are involved in the régulation of apoptosis, in particular, a family of bioactive lipids : sphingolipids. The recent studies have shown that the interactions between endoplasmic reticulum (ER) and mitochondria (via a specific region of the ER called Mitochondria associated membrane, MAM) are also involved in the regulation of apoptosis. We have developed a subcellular fractionation protocol for the isolation of mitochondria fraction, purified mitochondria and MAM. The proteic and lipidic compositions of these fractions were analyzed by WB and HPLC-MS. We compared the compositions of subcellular fractions at normal and apoptotic conditions. Our results show that induction of apoptosis causes the redistribution of the Bcl-2 family proteins including Bax transduction to mitochondria and MAM and an important increase of Bcl-2 expression at MAM Regarding lipid profiles, inductions of apoptosis increases ceramide level at mitochondria and decreases sphyngomyelin in the MAM fraction. Taken together, these results may suggest that the MAM could play an important role in the subcellular localization of Bcl-2 family proteins during apoptosis, potentially through synthesis and/or trafficking of sphingolipids
White, Sarah. « Pro-apoptotic bax and bak control beta-cell death and early endoplasmic reticulum stress signalling ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44609.
Texte intégralSemendary, Ali A. « Behavior of Adjacent Prestressed Concrete Box Beam Bridges Containing Ultra High Performance Concrete (UHPC) Longitudinal Joints ». Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1518181442348314.
Texte intégralTolley, Rebecca. « Review of Bad Boy of Gospel Music : The Calvin Newton Story, by Russ Cheatham ». Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/5611.
Texte intégralHaluška, Ľuboš. « Spojitý komorový nosník přes údolí ». Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409964.
Texte intégralHansson, Anna. « Balans i bas och kropp : En basists sittställning och hur det påverkar ljudet ». Thesis, Kungl. Musikhögskolan, Institutionen för klassisk musik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-2788.
Texte intégralAbout your seating position and how to produce sound. A study of how double basists use their bodies and how to play double bass without injuring your body.
G. Bottesini "Elegy no.3". Pianist Erik Lanninger
A. Vivaldi "Cello sonata no.3 in A-minor" Cembalo Anna Paradiso
A. Pärt "Spiegel im Spiegel". Pianist Erik Lanninger
E. Bloch "The Prayer" från "Jewish Life". Pianist Helena Hansson
G. Bottesini "Concerto for Double Bass and Orchestra no.2 in B-minor". Violin Lina Samuelsson, Lisa Chenevier, viola Doris Mägi, cello Viktoria Hillerhud, kontrabas Jennifer Downing Olsson.
I tillhörande video förekommer Prayer av Bloch och Elegy av Bottesini. Medverkar gör Helena Hansson och Erik Lanninger.
Anger, Moris. « Expressão de proteínas da apoptose em melanoma cutâneo primário ». Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5158/tde-15042009-162410/.
Texte intégralCutaneous melanoma still constitutes the main cause of skin cancer death in developed world. Clinical behavior variability of this neoplasia has been only partially explained by clinical and histological aspects, and identification of biological variables can be important for determining specific risk groups. Sixty nine (69) patients with mild to severe primary cutaneous melanoma treated in 1990-2007 were studied aiming at (a) verifying clinical epidemiological aspects, (b) generating a Tissue microarray (TMA) for characterizing proteins expression of cutaneous melanoma > 1.0 mm, (c) analyzing the immunohistochemical expression of the apoptosis proteins Bcl2, Bax, Bak, Apaf-1, Caspase 3, Caspase 9, Caspase 8, FasL e Fas in 10 control nevi and in primary melanomas with thickness 1mm, (d) and correlating these proteins expression with the disease prognosis. Results have ratified known epidemiological date on gender, age and lesion localization as well as the correlation between the disease prognosis and the Breslow\'s indexes. Analysis of the composite scores relating to apoptosis proteins has revealed that their immunohistochemical profile seems to be not significant for determining the disease prognosis, since no differences in proteins expression were found when compared patients with and without disease dissemination. Alterations in proteins expression suggesting their role in the genesis as well as in the prognosis of primary melanoma were not evidenced. Immunohistochemical profile with pro-apoptosis trend seems to indicate other factor as responsible for the neoplasia growth and dissemination
Su, Huizhong. « Metabolic basis of MYC-induced apoptosis ». Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31383.
Texte intégralTerliesner, Nicolas [Verfasser]. « Die Funktion der Proteine Bax und Bak in der Initiation von Apoptose durch das BH3-only-Protein Harakiri / Nicolas Terliesner ». Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1082237345/34.
Texte intégralGrönberg, Andreas. « Bow with Flow : Möjligheterna och svårigheterna i stråkspel på kontrabas inom jazz ». Thesis, Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79217.
Texte intégralFor a long time I have been thinking that the sound of a bowed tone is cool. There are recordings of music with jazz bowing, but it is not very common and I wondered why. Is it because there are too many difficulties with bowplaying? Or are there a lot of opportunities that only a few bass players take advantage of? The aim of my thesis is to figure out what the difficulties and the opportunities with bow playing on the double bass are in jazz music. In my research process I have chosen a couple of songs, rehearsed and recorded them with a band including drums, guitar, tenor saxophone and viola. After each recording session, I sended the recordings to a couple of active bow playing bass musicians, which answered with comments and advices. Based on the advices and my own analysis of the songs, I did exercises that taught me how to handle the difficulties and how to fully use the opportunities with bow playing in jazz music. In the beginning of the project I had some thoughts about what the opportunities and difficulties would be. Some of the thoughts came out to be, in some cases incorrect, in some cases partly correct and in some cases fully correct. An example is that, beginning my research I thought that playing rhythms with a bow would be difficult, but as it turned out, playing rhythms could also be an opportunity. I then could use more versatile rhythms than with my finger, since the bow allows me to hold a tone for a longer time.
Levecq, Guillaume. « L'organisation militaire de Philippe de Flandre dit "le Bon" dans les Grands Pays-Bas de 1419 à 1467 : une armée moderne invaincue ? » Paris, EPHE, 2008. http://www.theses.fr/2008EPHE4031.
Texte intégralBowman, Lindell Jenny. « "Bad boys" - företeelsen i fyra amerikanska och engelska romaner ». Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9135.
Texte intégralShi, Feng. « Local Part Model for Action Recognition in Realistic Videos ». Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31147.
Texte intégralPech, Zdeněk. « Konstrukční návrh pedálové skupiny formulového vozidla ». Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230200.
Texte intégralIshii, Priscila Lumi [UNESP]. « Efeito α-tomatina na proliferação celular, apoptose e expressão de RNAm dos genes APC, Ciclina A2, Catenina, CASP9, BAK, BAX e BCL-XL em células HT29 ». Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/87688.
Texte intégralCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A Nutrigenômica é definida como o efeito da dieta na expressão gênica, e a extensão pela qual as diferenças genéticas entre os indivíduos influenciam a resposta a um padrão específico de dieta, à ingestão de alimentos funcionais e à suplementação de micronutrientes, em termos de um resultado para a saúde humana. A α-tomatina é um glicoalcalóide encontrado no tomate (Lycopersicon esculentum) que possui funções biológicas importantes como a redução dos níveis de colesterol LDL, inibição do crescimento de células cancerosas, estimulação do sistema imune e efeito antimetastático. O objetivo deste estudo foi avaliar a citotoxicidade da α-tomatina, os seus efeitos na proliferação celular, na indução de apoptose e expressão de RNAm dos genes APC, Ciclina A2, Catenina, CASP9, BAK, BAX e BCL-XL em células HT29. As células foram cultivadas em meio de cultura DMEM, suplementado com 10% de soro bovino fetal, e tratadas nas concentrações de 0,1, 1 e 10 μg/mL para o ensaio do MTT e proliferação celular. Na análise de apoptose morfológica utilizou-se as concentrações de 0,1, 1 e 2 μg/mL. Já para a avaliação da expressão gênica utilizou-se a concentração de 1 μg/mL. Após 12 horas de tratamento, o RNA das células foi extraído e a expressão dos genes foi avaliada através do método de PCR em tempo real. O gene GPDH foi utilizado como normalizador. A análise estatística foi realizada por ANOVA/Tukey para o ensaio do MTT. Os resultados do ensaio de cinética de proliferação celular, viabilidade celular e avaliação da indução de apoptose foram analisados estatisticamente através de ANOVA/Dunnet, e para a análise da expressão gênica utilizou-se o método de Pfaffl et al. (2002), através do cálculo estimado pelo método ΔΔCt. Os estudos experimentais indicaram que a α-tomatina foi citotóxica apenas na concentração de 10 μg/mL...
Nutrigenomics is defined as the effect of diet on gene expression, and the extent to which genetic differences between individuals influence the response to a specific pattern of diet, intake of functional foods and micronutrient supplementation, in terms of a result for human health. The α- tomatine is highlighted as a glycoalkaloid found in tomato (Lycopersicon esculentum) that has important biological functions such as reducing levels of LDL cholesterol, inhibit cancer cell growth, stimulation of the immune system and antimetastátic effect. In view of these considerations, the objective of this study was to evaluate the cytotoxicity of α-tomatine, their effects on cell proliferation, induction of apoptosis and morphological expression of mRNA of APC gene, Cyclin A2, β-Catenin, CASP9, BAK, BAX and BCL-XL in HT29 cells. The cells were grown in DMEM culture medium supplemented with 10% fetal bovine serum, and treated at concentrations of 0.1, 1 and 10μg/mL for the MTT assay and cell proliferation. In the morphological analysis of apoptosis, we used concentrations of 0.1, 1 and 2μg/mL. As for the evaluation of gene expression we used a concentration of 1 mg/mL. After 12 hours of treatment, the RNA from cells was extracted and gene expression was evaluated by the method of real-time PCR. The gene GPDH was used as normalizer. Statistical analysis was performed by ANOVA / Tukey test for MTT. The test results of kinetics of cell proliferation, cell viability and assessment of apoptosis were analyzed with ANOVA / Dunnet, and for analysis of gene expression we used the method of Pfaffl et al. (2002), by calculating estimated by ΔΔCt. Experimental studies suggested that α-tomatine was cytotoxic only at concentration of 10μg/mL. In the evaluation of cell proliferation were no significant differences in the treatments with α-tomatine, except that for the concentration... (Complete abstract click electronic access below)
Ishii, Priscila Lumi. « Efeito α-tomatina na proliferação celular, apoptose e expressão de RNAm dos genes APC, Ciclina A2, Catenina, CASP9, BAK, BAX e BCL-XL em células HT29 / ». Rio Claro : [s.n.], 2011. http://hdl.handle.net/11449/87688.
Texte intégralBanca: Daniel Araki Ribeiro
Banca: Maria Izabel Souza Camargo
Resumo: A Nutrigenômica é definida como o efeito da dieta na expressão gênica, e a extensão pela qual as diferenças genéticas entre os indivíduos influenciam a resposta a um padrão específico de dieta, à ingestão de alimentos funcionais e à suplementação de micronutrientes, em termos de um resultado para a saúde humana. A α-tomatina é um glicoalcalóide encontrado no tomate (Lycopersicon esculentum) que possui funções biológicas importantes como a redução dos níveis de colesterol LDL, inibição do crescimento de células cancerosas, estimulação do sistema imune e efeito antimetastático. O objetivo deste estudo foi avaliar a citotoxicidade da α-tomatina, os seus efeitos na proliferação celular, na indução de apoptose e expressão de RNAm dos genes APC, Ciclina A2, Catenina, CASP9, BAK, BAX e BCL-XL em células HT29. As células foram cultivadas em meio de cultura DMEM, suplementado com 10% de soro bovino fetal, e tratadas nas concentrações de 0,1, 1 e 10 μg/mL para o ensaio do MTT e proliferação celular. Na análise de apoptose morfológica utilizou-se as concentrações de 0,1, 1 e 2 μg/mL. Já para a avaliação da expressão gênica utilizou-se a concentração de 1 μg/mL. Após 12 horas de tratamento, o RNA das células foi extraído e a expressão dos genes foi avaliada através do método de PCR em tempo real. O gene GPDH foi utilizado como normalizador. A análise estatística foi realizada por ANOVA/Tukey para o ensaio do MTT. Os resultados do ensaio de cinética de proliferação celular, viabilidade celular e avaliação da indução de apoptose foram analisados estatisticamente através de ANOVA/Dunnet, e para a análise da expressão gênica utilizou-se o método de Pfaffl et al. (2002), através do cálculo estimado pelo método ΔΔCt. Os estudos experimentais indicaram que a α-tomatina foi citotóxica apenas na concentração de 10 μg/mL... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Nutrigenomics is defined as the effect of diet on gene expression, and the extent to which genetic differences between individuals influence the response to a specific pattern of diet, intake of functional foods and micronutrient supplementation, in terms of a result for human health. The α- tomatine is highlighted as a glycoalkaloid found in tomato (Lycopersicon esculentum) that has important biological functions such as reducing levels of LDL cholesterol, inhibit cancer cell growth, stimulation of the immune system and antimetastátic effect. In view of these considerations, the objective of this study was to evaluate the cytotoxicity of α-tomatine, their effects on cell proliferation, induction of apoptosis and morphological expression of mRNA of APC gene, Cyclin A2, β-Catenin, CASP9, BAK, BAX and BCL-XL in HT29 cells. The cells were grown in DMEM culture medium supplemented with 10% fetal bovine serum, and treated at concentrations of 0.1, 1 and 10μg/mL for the MTT assay and cell proliferation. In the morphological analysis of apoptosis, we used concentrations of 0.1, 1 and 2μg/mL. As for the evaluation of gene expression we used a concentration of 1 mg/mL. After 12 hours of treatment, the RNA from cells was extracted and gene expression was evaluated by the method of real-time PCR. The gene GPDH was used as normalizer. Statistical analysis was performed by ANOVA / Tukey test for MTT. The test results of kinetics of cell proliferation, cell viability and assessment of apoptosis were analyzed with ANOVA / Dunnet, and for analysis of gene expression we used the method of Pfaffl et al. (2002), by calculating estimated by ΔΔCt. Experimental studies suggested that α-tomatine was cytotoxic only at concentration of 10μg/mL. In the evaluation of cell proliferation were no significant differences in the treatments with α-tomatine, except that for the concentration... (Complete abstract click electronic access below)
Mestre
COSTA, Caroline Barra Sales Khayat da. « Monitoramento do estabelecimento das bact?rias presentes no inoculante da Embrapa Agrobiologia, durante o desenvolvimento inicial de plantas de cana-de-a??car utilizando t?cnicas microbiol?gicas e moleculares ». Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/2463.
Texte intégralMade available in DSpace on 2018-09-21T19:29:33Z (GMT). No. of bitstreams: 1 2016 - Caroline Barra Sales Khayat da Costa.pdf: 5220401 bytes, checksum: 553248261c960b6b5fb62cadb1b26ebf (MD5) Previous issue date: 2016-07-26
CAPES
One of the most known and important process in nature is the biological nitrogen fixation (FBN). Few classes of microorganisms perform this process; named diazotrophics that associated with plants is an important alternative to enhance nitrogen nutrition in agricultural systems. Diazotrophic bacterial population in association with sugarcane improves the yield due to its ability to colonize the inner roots of the host plant and do not provoke any pathogenicity signal. Quantitative analyzes have indicated that selection of combinations of endophytic diazotrophic strains when associated with sugarcane varieties can improve the yield and therefore varieties of sugarcane may be better exploited in order to benefit this association for agricultural purposes. Thus, this work proposes to monitor the establishment of diazotrophic bacteria present in the inoculant of Embrapa, during the initial development of sugarcane plants. Micro-propagated sets of the sugarcane variety RB867515 were inoculated individually and with a mixture of five nitrogen fixing bacteria strains that compose the sugarcane inoculant: Nitrospirillum amazonense (CBAmC) Paraburkholderia tropica (Ppe8) Gluconacetobacter diazotrophicus (Pal5) Herbaspirillum seropedicae (HRC54) and Herbaspirillum rubrisubalbicans (HCC103). Plants were grown in a greenhouse and harvested 30 days after planting. Fresh root material was separated for evaluation of the establishment of the strains by bacterial counting using the technique of Most Probable Number (MPN), absolute quantification by Real Time PCR (qPCR), besides the identification of the inoculated strains through analysis of the rDNA profile of the pellicle formed in the respective semisolid media using the BOX-PCR technique. The results of bacterial count diazotrophic present in the roots by NMP showed that the treatments inoculated in the control (native population) showed higher population of bacterial cells around 105 cells by fresh root mass, but not statistically significant. The methodology qPCR permitted quantitation of the number of 16S rDNA copies in the order of 105 bacterial cells g - 1 fresh weight root, showing that there were differences in the population of endophytic species that colonize the roots of sugarcane. The profiles of BOX -PCR of the respective pellicles formed in semisolid media did not show high similarity (> 80 %) with the profile of the species inoculated for most of the treatments. The results obtained indicate that the qPCR technique showed the establishment of some of the inoculated strains in sugar cane buds while the NMP technique showed no significant difference between treatments inoculated and non-inoculated possibly due to the lower sensitivity of the method.
Um dos processos mais conhecidos e importantes na natureza ? a fixa??o biol?gica de nitrog?nio atmosf?rico (FBN). Este processo ? realizado por algumas classes de microrganismos, denominados diazotr?ficos, que associados com esp?cies vegetais s?o uma alternativa importante para aprimorar a nutri??o nitrogenada nos sistemas agr?colas. As popula??es de bact?rias fixadoras de nitrog?nio atmosf?rico quando associadas ? cultura da cana-de-a??car melhoram a produ??o e, ao colonizarem o interior das ra?zes promovem benef?cios ?s plantas hospedeiras. An?lises quantitativas t?m indicado que a sele??o das combina??es de estirpes de bact?rias diazotr?ficas endof?ticas e variedades de cana-de-a??car podem ser melhor exploradas com o objetivo de aperfei?oar a associa??o para finalidades agr?colas. Assim, o presente trabalho prop?e monitorar o estabelecimento das bact?rias diazotr?ficas presentes no inoculante para cana-de- a??car da Embrapa, durante o desenvolvimento inicial planta. Toletes propagados da variedade RB867515 de cana-de-a??car foram inoculados individualmente e com a mistura das cinco estirpes de bact?rias diazotr?ficas: Nitrospirillum amazonense (CBAmC), Paraburkholderia tropica (PPe8), Gluconacetobacter diazotrophicus (Pal5), Herbaspirillum seropedicae (HRC54) e Herbaspirillum rubrisubalbicans (HCC103). As plantas foram crescidas em casa de vegeta??o e coletadas 30 dias ap?s o plantio, sendo separado o material vegetal para avalia??o do estabelecimento das estirpes pela t?cnica do N?mero Mais Prov?vel (NMP) e quantifica??o absoluta por PCR em Tempo Real (qPCR). Adicionalmente foi feita a identifica??o das estirpes inoculadas atrav?s da an?lise do perfil de rDNA das pel?culas bacterianas formadas nos respectivos meios semiss?lidos pela t?cnica de BOX-PCR. Os resultados obtidos da contagem de bact?rias diazotr?ficas presente nas ra?zes por NMP mostrou que os tratamentos inoculados em rela??o ao controle (popula??o nativa), apresentaram uma maior popula??o de c?lulas bacterianas em torno de 105 c?lulas por massa fresca de raiz, por?m n?o significativa. A metodologia de qPCR permitiu a quantifica??o do n?mero de c?pias do 16S rDNA, da ordem de 105 c?lulas bacterianas g-1 massa fresca de raiz, mostrando que houve diferen?a na popula??o das esp?cies diazotr?ficas endof?ticas que colonizam as ra?zes de cana-de-a??car. Os perfis obtidos por BOX-PCR das pel?culas formadas nos respectivos meios semiss?lidos n?o mostraram alta similaridade (>80%) com o perfil das esp?cies inoculadas para a maioria dos tratamentos inoculados. Os resultados obtidos indicam que a t?cnica de qPCR permitiu mostrar o estabelecimento de algumas estirpe do inoculante nos toletes de cana-de a??car enquanto que a t?cnica de NMP n?o mostrou diferen?a significativas entre os tratamentos inoculados e n?o inoculados possivelmente pela menor sensibilidade da metodologia.
Reusch, Frederik [Verfasser], Dietmar [Gutachter] Klingbeil, Paul [Gutachter] Steinmann et Bob [Gutachter] Svendsen. « Entwicklung und Anwendung eines nicht-lokalen Materialmodells zur Simulation duktiler Schädigung in metallischen Werkstoffen / Frederik Reusch ; Bundesanstalt für Materialforschung und -prüfung (BAM) ; Gutachter : Dietmar Klingbeil, Paul Steinmann, Bob Svendsen ». Berlin : Bundesanstalt für Materialforschung und -prüfung (BAM), 2003. http://d-nb.info/1122836651/34.
Texte intégralBellot, Grégory Vallette François. « Identification de nouveaux récepteurs mitochondriaux impliqués dans l'association des protéines pro-apoptotiques Bax et Bak avec la membrane externe au cours de l'apoptose mise en évidence d'un nouveau système de régulation / ». [S.l.] : [s.n.], 2006. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=26786.
Texte intégralGajová, Veronika. « Automatické třídění fotografií podle obsahu ». Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236565.
Texte intégralFrancis, Crystal Raquel. « Reentry Practitioners' Perceptions of Constraints During Ex-offenders' Job Search Process ». ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5463.
Texte intégralNěmec, Lukáš. « Lokalizace mobilního robota v prostředí ». Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2016. http://www.nusl.cz/ntk/nusl-255455.
Texte intégralCasado, Marcio Mello. « Abuso de direito processual do credor instituição financeira ». Pontifícia Universidade Católica de São Paulo, 2011. https://tede2.pucsp.br/handle/handle/5542.
Texte intégralOver the last sixteen years, Brazil has gone through important legislative modifications, which have been motivated by the need, in the economical field, of reducing the interests rate and the banking spread. The changes that have occurred, not only in civil procedure, were encouraged by the financial institutions and by the Central Bank of Brazil, through a series of annual reports. The model in which the modifications were based had as its foundation the paradigm that the lack of effectiveness in the civil procedure was the result of a system that granted many guarantees to the creditor, which would make it difficult for the credits to be obtained in court. In the field of substantial law, the legislation would obstruct a series of contractual practices carried out by the financial institutions, once abusive. The Judicial System, when interpreting these rules in force, would have an inadequate position, contrary to the interests of the financial institutions. The system would suffer from a moral risk. The legislation has been modified. Licit situations have become illicit. New forms of enforcement and its instruments have been created or improved. Although, the system still suffers from the sluggishness for parties to obtain their credits in court. The interests rate and the banking spread remain high. The diagnosis was mistaken. The obtaining of the credits in court was slow not because the Judiciary System was being lenient with de debtors, or because the legislation was retrograde or excessively protective. The abuse of procedural right by the financial institutions, with the sole aim of enforcing the contractual illegalities and to force the performance of undue installments is the cause for the delay on the closure of the law suits. The financial institutions, assumingly acting in bad faith, insist on using excessive procedural tools, in order to try to make illegality prevail. The process ends up operating not as a means of enforcing justice, but as a way to blackmail and to discourage the debtor of proceeding in the defense of his legitimate rights. However, one of the damaged parties by the abuse of procedural right is the creditor himself, as far as, with the reaction of the good faith debtor, the process tends to procrastinate, not because the debtor is not right, the opposite: the debtor is right and the creditor can t cope with this fact. Notwithstanding, the abuse of procedural right can only succeed when there is an active or omissible collaboration of the Judicial System. Jurisdiction becomes a means of realization of the abuse, instead of being the least likely place for it to be found in. At last, all the parties involved lose with the abuse of procedural right: the debtor, once, in some moment, could give up, even having the law on his side; the creditor, because it will take a long time for him to obtain his credit; the State, once the Judicial System must administrate a litigation which could have been solved way before. Also, the collectivity, under a diffuse point of view. The abuse of procedural right needs treatment, and this could be preventive, corrective or compensating
Nos últimos dezesseis anos, o Brasil sofreu importantes modificações legislativas motivadas pela necessidade, no âmbito econômico, de se reduzirem os juros e o spread bancário. As modificações que houve, não só no processo civil, foram incentivadas pelas instituições financeiras e pelo Banco Central do Brasil, em uma série de relatórios anuais. O modelo em que se fundamentaram as alterações tinha como base o paradigma de que a falta de efetividade no processo civil era fruto de um sistema que conferia muitas garantias ao devedor, o que dificultaria o recebimento dos créditos em juízo. No âmbito do direito material, a legislação impediria uma série de práticas contratuais das instituições financeiras, porque abusivas. O judiciário, ao interpretar tais normas vigentes, teria uma postura inadequada, contrária aos interesses das instituições financeiras. O sistema padeceria de um risco moral. A legislação foi modificada. O que era ilícito passou a ser permitido. Novas formas de execução e meios executivos foram criados ou aperfeiçoados. Todavia, o sistema ainda padece com a lentidão no recebimento de créditos em juízo. Os juros e o spread bancário continuam elevados. O diagnóstico foi equivocado. O recebimento de créditos bancários em juízo era lento não porque o judiciário fosse leniente com os devedores, a legislação fosse retrógada ou excessivamente protetiva. O abuso de direito processual das instituições financeiras, com o objetivo de fazer valer os ilícitos contratuais e forçar o adimplemento de parcelas indevidas é que causa o retardamento da conclusão dos processos. As instituições financeiras, em presumida má-fé, insistem em se valer de meios processuais excessivos para fazer com que prevaleça a ilegalidade. O processo acaba servindo não como um meio de se fazer justiça, mas como uma forma de chantagem, um meio para desencorajar o devedor de prosseguir na defesa de seus legítimos direitos. Entretanto, um dos lesados com o abuso do direito processual é o próprio credor, na medida em que, na reação do devedor de boa-fé, o processo tende a se prolongar no tempo, não porque o devedor não tenha razão, ao contrário, porque ele a tem e o credor não se conforma com isto. O abuso de direito processual somente obtém sucesso quando há colaboração, ativa ou omissiva, do Poder Judiciário A jurisdição passa a ser um meio para realização do abuso, ao invés de ser o último local onde ele deveria existir. No final, todos os envolvidos perdem com o abuso de direito processual: o devedor, porque em algum momento pode ceder, mesmo tendo o direito a seu favor; o credor, porque demora a receber; o Estado, pois o Poder Judiciário tem de administrar um litígio que poderia ser resolvido muitos antes. A coletividade, dentro de uma visão difusa. O abuso de direito processual necessita de tratamento e ele pode ser preventivo, corretivo ou ressarcitório
Kotsafti, Andromachi. « Meccanismi estrinseci ed intrinseci del processo apoptotico nell'epatocarcinogenesi ». Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425956.
Texte intégralFeitosa, Neto Antonino Alves. « An?lise das medidas de boa e m ? diversidade na constru??o de comit?s de classificadores atrav?s de metaheur?sticas de otimiza??o multiobjetivo ». Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18062.
Texte intégralCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Committees of classifiers may be used to improve the accuracy of classification systems, in other words, different classifiers used to solve the same problem can be combined for creating a system of greater accuracy, called committees of classifiers. To that this to succeed is necessary that the classifiers make mistakes on different objects of the problem so that the errors of a classifier are ignored by the others correct classifiers when applying the method of combination of the committee. The characteristic of classifiers of err on different objects is called diversity. However, most measures of diversity could not describe this importance. Recently, were proposed two measures of the diversity (good and bad diversity) with the aim of helping to generate more accurate committees. This paper performs an experimental analysis of these measures applied directly on the building of the committees of classifiers. The method of construction adopted is modeled as a search problem by the set of characteristics of the databases of the problem and the best set of committee members in order to find the committee of classifiers to produce the most accurate classification. This problem is solved by metaheuristic optimization techniques, in their mono and multi-objective versions. Analyzes are performed to verify if use or add the measures of good diversity and bad diversity in the optimization objectives creates more accurate committees. Thus, the contribution of this study is to determine whether the measures of good diversity and bad diversity can be used in mono-objective and multi-objective optimization techniques as optimization objectives for building committees of classifiers more accurate than those built by the same process, but using only the accuracy classification as objective of optimization
Comit?s de classificadores podem ser empregados para melhorar a acur?cia de sistemas de classifica??o, ou seja, diferentes classificadores aplicados ? solu??o de um mesmo problema podem ser combinados gerando um sistema de maior acur?cia, denominado de comit?s de classificadores. Para que se obtenha sucesso ? necess?rio que os classificadores apresentem erros em diferentes objetos do problema para que assim os erros de um classificador sejam suprimidos pelo acerto dos demais na aplica??o do m?todo de combina??o do comit?. A caracter?stica dos classificadores de errarem em objetos diferentes ? denominada de diversidade. No entanto, as maiorias das medidas de diversidade n?o conseguiam descrever essa import?ncia. Recentemente, foram propostas duas medidas de diversidade (boa e m? diversidade) as medidas de boa e m? diversidade com o objetivo de auxiliar a gera??o de comit?s mais acurados. Este trabalho efetua uma an?lise experimental dessas medidas aplicadas diretamente na constru??o de comit?s de classificadores. O m?todo de constru??o adotado ? modelado como um problema de busca pelo melhor conjunto de caracter?sticas das bases de dados do problema e pelo melhor conjunto de membros do comit? a fim de encontrar o comit? de classificadores que apresente ? maior acur?cia de classifica??o. Esse problema ? resolvido atrav?s de t?cnicas de otimiza??o metaheur?sticas, nas vers?es mono e multiobjetivo. S?o efetuadas an?lises estat?sticas para verificar se usar ou adicionar as medidas de boa e m? diversidade como objetivos de otimiza??o resulte comit?s mais acurados. Assim, a contribui??o desse trabalho ? determinar se as medidas de boa e m? diversidade podem ser utilizadas em t?cnicas de otimiza??o mono e multiobjetivo como objetivos de otimiza??o para constru??o de comit?s de classificadores mais acurados que aqueles constru?dos pelo mesmo processo, por?m utilizando somente a acur?cia de classifica??o como objetivo de otimiza??o
Janek, Tomáš. « Předpjatý most číslo 202 na rychlostní komunikaci R2 na Slovensku ». Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2015. http://www.nusl.cz/ntk/nusl-227822.
Texte intégralAbid, Muhammad Rizwan. « Visual Recognition of a Dynamic Arm Gesture Language for Human-Robot and Inter-Robot Communication ». Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32800.
Texte intégralSommé, Monique. « Isabelle de Portugal, duchesse de Bourgogne, une femme au pouvoir au quinzième siècle ». Lille 3, 1995. https://books.openedition.org/septentrion/121370.
Texte intégralIsabel of Portugal, became in 1430 wife of Philip the Good, duke of Burgundy, has exercised her authority and her protection on a large family compound of her son Charles, bastards of the duke, cousins, nepews and nieces, some of whom were portuguese. She had at one's disposal abundant resources, some attributed to the maitre de la chambre aux deniers for the functioning of her household, others own stocks coming from her domains in Flanders, Artois and Burgundy, gifts or taxes. Her household more four hundred persons of whom were identified constituted a protected environment of men and women, nobles and commoners, who shared her itinerant life, mainly in low countries. The stability of the employment was remarkable. The duchess was associated to the state government by the duke and, in his absence, was appointed to govern. She has showed a great competence in the financial administration and acted efficiently in the diplomatic relations of burgundy with england and France. According to her request her househould was broken-up in 1455 and in 1457 she retired out of the court to life in charity and to encourage the new forms of religious life, but she came back to the public life during the first years (1467-1471) of the reign of Charles the Bold
Mertová, Eliška. « Dálniční most přes široké údolí ». Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265345.
Texte intégralČerná, Klára. « Charakterizace adsorbčních vlastností probiotických bakterií ». Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376799.
Texte intégralGonzalez, Vieyra Joel Abraham. « Estimation et Contrôle des Systèmes Dynamiques à Entrées Inconnues et Energies Renouvelables ». Thesis, Ecole centrale de Lille, 2019. http://www.theses.fr/2019ECLI0012/document.
Texte intégralNowadays, industrial processes must be efficient, particularly at the production level and/or energy consumption.This research work aims at improving the process efficiency by analysing the influences of disturbances on their behaviour, from the conception phase to the synthesis of controller/observer, in an integrated approach.The disturbance rejection problem is first introduced as well as different control laws allowing attenuate/reject these disturbances. A control law based on the concept of derivative state variable is presented and validated while applied as disturbance rejection.In order to reject the disturbance, different physical variables must be estimated, such as state variables, derivative state variables as disturbance variables. An unknown input observer based on the bond graph representation is recalled and extended in the multivariable case. It is the first theoretical contribution of this work.We thus compare the efficiency of different so-called «modern control laws» for the disturbance rejection problems by simulation with the Torsion-Bar system example. We analyse the efficiency of our approach. One extension to the Input-Output decoupling problem allows us to extend the disturbance rejection problem to other control law type in an integrated approach. At least, these techniques are applied on the real Torsion-Bar system and compared. We validate our approach.Since this work aims at analysing and developing efficient control laws for industrial processes, a simplified model of a hydroelectric plant is developed, in order to apply our results. A simplified bond graph model is validated with simulations
Cerisuelo, Marc. « L'Instauration du cinéma : Poétique des films et interprétation : L'exemple des métafilms hollywoodiens ». Paris 3, 1998. http://www.theses.fr/1998PA030188.
Texte intégralThe object of this study is to establish the relationships between poetics of film, film history and the claim of an interpretation based upon a literary background and a philosophical point of view. A "metafilm" is not just one more "movie-about-themovies". This study will attempt to show how, from show people to fedora, the hollywood tradition provides a real discourse of the film
Pappas, Adlreburg Nickolas. « To Make Iron of Iron : A Comprehensive Analytical Study of Spade Shaped Iron Bars ». Thesis, Stockholms universitet, Arkeologiska forskningslaboratoriet, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-145694.
Texte intégralMALTAGLIATI, GIACOMO. « Behavioral ecology of bats in urban and suburban areas : an eco-ethological approach to conservation ». Doctoral thesis, 2012. http://hdl.handle.net/2158/797276.
Texte intégral« "Should it even be a question?" : A critical discourse analysis of efforts to remove barriers to college admission for people with criminal convictions ». Tulane University, 2021.
Trouver le texte intégralIn this dissertation, I analyze the development and dissemination of state-level policies to prohibit colleges from considering criminal history for purposes of admissions otherwise known as ban the box in higher education. This research engages with practical and instructive questions of how individuals or coalitions can learn from other policy campaigns to strategically reduce the collateral consequences of criminal convictions. I conducted a collective case study of the first five states to introduce ban the box in higher education legislation, namely New York, Illinois, Maryland, Louisiana, and Washington. I used critical discourse analysis to analyze all available media and social media content to identify where legislation was filed and major stakeholders. I then transcribed and analyzed all available legislative hearings and interviewed key stakeholders to determine the dominant discourses within and across five states. The study found that legislators and advocates evoked the following arguments in opposition to ban the box in higher education: positive self/ negative other, paternalistic decision making, uselessness, and fear of the undeserving. In support, advocates and legislators used arguments that emphasized individual benefits, community benefits, and diversity. Advocates in support also presented personal testimony from formerly incarcerated students and alumni to humanize people with convictions. The findings illuminate possible strategies and barriers to passing supportive policy that reduces collateral consequences and limits the reach of the criminal legal system.
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Annie Phoenix
CHIN-ERH, CHANG, et 張進二. « Research on Optimized Inclination of Bar-Screen Installed where an open Channel Connecting to a Box Culvert ». Thesis, 2011. http://ndltd.ncl.edu.tw/handle/53112595646691605844.
Texte intégral國立高雄應用科技大學
土木工程與防災科技研究所
99
This study is devoted to the research and development of the bar screen with garbage-cleaning platform installed at the junction where an open channel connects to a box culvert and the design of the bar screen’s optimized inclination. Firstly, the inclination of the bar screen that would not obstruct the drainage area of the box culvert is derived. Secondly, this study obtains the angle that enables the garbage and driftwoods to overcome the friction of the inclining bars and climb up to the garbage-cleaning platform by themselves. Based on the equal number of the above-mentioned degree of inclination, the garbage-cleaning platform is designed. This cleaning platform makes it possible for the garbage and driftwoods to climb up by themselves and does not obstruct the optimized inclination of the box culvert’s drainage area and the best width in cooperation with the iron components of the bar screen. Through interior and exterior hydraulic model tests, it is proved that the best angle for #3-bamboo-steel bar screen which will enable the garbage to climb up to the cleaning platform and will not obstruct the drainage area of the box culverts is 45.14°, while that for bar screen made of smooth aluminum pipe is 60.23°