Bibliographies thématiques / Babesiosi

Littérature scientifique sur le sujet « Babesiosi »

Auteur : Grafiati
Publié le 11 mars 2023

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Articles de revues sur le sujet "Babesiosi"

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Tison, Tiziana, Piero Marson et Giustina De Silvestro. « Lo scambio eritrocitario ». Giornale di Clinica Nefrologica e Dialisi 25, no 4_suppl (23 juillet 2013) : S27—S29. http://dx.doi.org/10.33393/gcnd.2013.1086.

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Lo scambio eritrocitario è una procedura in cui, utilizzando un separatore cellulare, si rimuovono i globuli rossi anomali del paziente, che vengono rimpiazzati con globuli rossi di un donatore volontario. Lo scambio eritrocitario può essere effettuato sia utilizzando accessi venosi periferici che un catetere venoso centrale. Dal momento che spesso si tratta di pazienti pediatrici è importante valutare attentamente le indicazioni ed è necessario considerare alcuni aspetti particolari della procedura aferetica. Lo scambio eritrocitario è indicato in caso di complicanze severe della drepanocitosi, quali l'ictus e l'acute chest syndrome, e nel caso di alcune infezioni quali la malaria e la babesiosi, in cui si verifica, ad opera dei parassiti, un danno eritrocitario.
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Hosur, Srilatha, Delong Liu, Karen Seiter, John Nelson, Maria Aguero-Rosenfeld, Sergey Brodsky, Tauseef Ahmed et Gary Wormser. « Emerging Epidemics of Babesiosis in Hematology Consultation at a University Hospital. » Blood 110, no 11 (16 novembre 2007) : 3859. http://dx.doi.org/10.1182/blood.v110.11.3859.3859.

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Abstract Babesiosis was first reported in NY in 1975. 560 cases were reported from 1986–2001 in NY, mostly from Long island. Human babesiosis is a tick- borne disease caused by B.microti in the US. Most of the cases occur between May and August in the north eastern states. The risk factors for severe disease include older age, asplenia, immunocompromised state. As the same tick is the vector for lyme disease and ehrlichiosis, co-infection can occur. In this abstract we report ten cases of babesiosis encountered in hematology consultation since 2005, with 5 cases occurring this year. The patients’ ages ranged between 36–84 yrs. Three patients had neither travel history nor tick bite /outdoor activity. Three patients were immunocompromised (AML, CLL, HIV). Most common presentations were malaise, nausea, and high fever. Two patients had splenomegaly. Six patients had hyperbilirubinemia, anemia and thrombocytopenia. Three patients were also positive for lyme disease. One patient developed splenic rupture. All the patients recovered after treatment with atovoquone and azithromycin. This series of case reports emphasizes the varied atypical presentations of babesioisis including uncommon season of occurrence, absence of a rash or tickbite history, co-existing infection with Lyme disease and complications including splenic rupture.
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BEUGNET, F., et Y. MOREAU. « Babesiosis ». Revue Scientifique et Technique de l'OIE 34, no 2 (1 août 2015) : 627–39. http://dx.doi.org/10.20506/rst.34.2.2385.

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Noskoviak, Kyle, et Elizabeth Broome. « Babesiosis ». New England Journal of Medicine 358, no 17 (24 avril 2008) : e19. http://dx.doi.org/10.1056/nejmicm070903.

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Homer, Mary J., Irma Aguilar-Delfin, Sam R. Telford, Peter J. Krause et David H. Persing. « Babesiosis ». Clinical Microbiology Reviews 13, no 3 (1 juillet 2000) : 451–69. http://dx.doi.org/10.1128/cmr.13.3.451.

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SUMMARY Babesiosis is an emerging, tick-transmitted, zoonotic disease caused by hematotropic parasites of the genus Babesia. Babesial parasites (and those of the closely related genus Theileria) are some of the most ubiquitous and widespread blood parasites in the world, second only to the trypanosomes, and consequently have considerable worldwide economic, medical, and veterinary impact. The parasites are intraerythrocytic and are commonly called piroplasms due to the pear-shaped forms found within infected red blood cells. The piroplasms are transmitted by ixodid ticks and are capable of infecting a wide variety of vertebrate hosts which are competent in maintaining the transmission cycle. Studies involving animal hosts other than humans have contributed significantly to our understanding of the disease process, including possible pathogenic mechanisms of the parasite and immunological responses of the host. To date, there are several species of Babesia that can infect humans, Babesia microti being the most prevalent. Infections with Babesia species generally follow regional distributions; cases in the United States are caused primarily by B. microti, whereas cases in Europe are usually caused by Babesia divergens. The spectrum of disease manifestation is broad, ranging from a silent infection to a fulminant, malaria-like disease, resulting in severe hemolysis and occasionally in death. Recent advances have resulted in the development of several diagnostic tests which have increased the level of sensitivity in detection, thereby facilitating diagnosis, expediting appropriate patient management, and resulting in a more accurate epidemiological description.
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Boustani, M. R., et J. A. Gelfand. « Babesiosis ». Clinical Infectious Diseases 22, no 4 (1 avril 1996) : 611–15. http://dx.doi.org/10.1093/clinids/22.4.611.

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Butler-Haughton, Melissa. « Babesiosis ». Workplace Health & ; Safety 68, no 11 (27 octobre 2020) : 545. http://dx.doi.org/10.1177/2165079920964797.

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Wiese, Kristin M., et Gökhan M. Mutlu. « Babesiosis ». American Journal of Respiratory and Critical Care Medicine 189, no 5 (mars 2014) : 602. http://dx.doi.org/10.1164/rccm.201309-1740im.

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Setty, Suman, Zena Khalil, Pamela Schori, Miguel Azar et Patricia Ferrieri. « Babesiosis ». American Journal of Clinical Pathology 120, no 4 (octobre 2003) : 554–59. http://dx.doi.org/10.1309/n3dp9mfpnujd4xjy.

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Barto, Donna, et Jill Brzozowski. « Babesiosis ». Nursing Critical Care 9, no 4 (juillet 2014) : 23–25. http://dx.doi.org/10.1097/01.ccn.0000451018.61832.49.

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Thèses sur le sujet "Babesiosi"

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Garrido, Castañé Ignasi. « Epidemiologia de l’anaplasmosi, babesiosi i besnoitiosi en bovins a Catalunya ». Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/311619.

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L'anaplasmosi, la babesiosi i la besnoitiosi es troben entre les malalties bovines poc conegudes i estudiades a Catalunya. A dia d'avui, més enllà de descripcions i comunicacions puntuals no disposem de cap estudi epidemiològic que ens permeti conèixer el seu estat actual. Amb el propòsit d'iniciar aquests estudis es planteja el present treball de Tesi Doctoral, centrat en l'estudi d'Anaplasma spp., Babesia bigemina i Besnoitia besnoiti. La prevalença dels dos hemoparàsits es va determinar a través de l’anàlisi de sèrums de diferents poblacions bovines. La metodologia va consistir en tècniques d’ELISA. L’estudi estadístic dels resultats i de diferents factors de risc associats a l’animal, el maneig i localització de l’explotació es va realitzar amb un model lineal generalitzat. Les seroprevalences observades van ser aproximadament d’un 40 % per a l’anaplasmosi i un 54,4 % per a la babesiosi causada per B. bigemina. L’edat i la cria en extensiu es van establir com a factors determinants. L'estudi de B. besnoiti consta a la vegada de dues parts. En la primera part, es van analitzar sèrums de bovins procedents de les zones nord i sud de Catalunya. mitjançant una tècnica d’ELISA L’estudi estadístic de les dades es va basar en un model lineal generalitzat. Els resultats de seroprevalença obtinguts van ser d'un 64 %. En la segona part de l'estudi de B. besnoiti es van obtenir mostres de globus oculars i de sang de 206 animals sacrificats en dos escorxadors de la comarca de la Garrotxa. Es van observar els quists escleroconjuntivals en un 3,9 % dels animals estudiats, mentre que la seroprevalença en els mateixos animals va ser d'un 29,6 %. Les seroprevalences obtingudes per a les hemoparasitosis i la besnoitiosi bovina mostren que s’haurien d’incloure en el diagnòstic diferencial de les malalties bovines a la nostra zona.
Anaplasmosis, babesiosis and besnoitiosis are bovine diseases with limited information in Catalonia. Nowadays, except for brief descriptions, no epidemiological studies are available to know the current status. The main objective of this Doctoral Thesis is to initiate these studies focused on Anaplasma spp., Babesia bigemina and Besnoitia besnoiti. Hemoparasites seroprevalence were established by the analysis of samples from different cattle population. The methodology consisted in ELISA analysis of serum samples. The statistical study of the results and different risk factors from animals, management and geographic location were obtained using a generalized linear model. The overall seroprevalence to Anaplasma spp. was closely to 40 % and to B. bigemina was 54.4 %. Age and extensive management were determined as determinant factors. B. besnoiti study was divided in two parts. In the first one, serum samples from north and south areas from Catalonia were analysed by an ELISA technique. Data analysis was based on a generalized linear model. The seroprevalence was found to be 64 %. In the second part of B. besnoiti study, eyeball and blood samples were collected from 206 slaughtered cattle in two abattoirs from Garrotxa region. 3,9 % of studied animals showed sclero-conjunctival cysts, whereas the seroprevalence was 29,6 % in the same animals. The high seroprevalences detected for both hemoparasites and bovine besnoitia suggested they all should be included in differential diagnosis in bovine diseases in our area.
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Cassini, Rudi. « Aspetti epidemiologici e rischi zoonosici delle malattie trasmesse da vettori : Babesiosi e Leishmaniosi in Italia Nord-Orientale ». Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425483.

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Vector borne infections are now again a priority worldwide. Emergence or re-emergence of these diseases are usually associated with climatic change, but also other factor are involved, such as demographic, socio-economic and accidental factors. The results of 3 years epidemiolocal investigations about ruminants babesiosis and canine leishmaniosis in north-eastern Italy are presented. These two case studies show that these infections are a potential threat to Public Health. Outcomes of the research confirm the importance of a proper surveillance of vector-borne infections also in north-eastern Italy.
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Vargas, Hernández Giovanni [UNESP]. « Detecção parasitológica, molecular e sorológica de Erlichia canis e babesia canis em cães da região Centro-Oriental da Colômbia ». Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/89197.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
A babesiose e a erliquiose canina são doenças comuns em cães, transmitidas pelo vetor Rhipicephalus sanguineus. Os sinais e sintomas dessas doenças não são específicos. A detecção dos parasitos em esfregaços sanguíneos nem sempre é possível e a detecção sorológica pode indicar apenas que o animal teve contato com o agente, mas não necessariamente a doença ativa. Na Colômbia existem poucas pesquisas sobre a epidemiologia e diagnóstico de erliquiose e babesiose em cães, as poucas existentes se basearam na detecção dos hemoparasitas em esfregaços sanguíneos, ou de anticorpos específicos. Sendo assim propos-se este estudo com o objetivo de pesquisar a erliquiose e a babesiose em esfregaços sangüíneos associados a provas sorológicas e moleculares em cães da região centro-oriental de Colômbia. Amostras de sangue e soro de 91 cães, provenientes das cidades de Bogotá (n=21), Villavicencio (n=31) e Bucaramanga (n=39) foram submetidas a pesquisa parasitológica, detecção de anticorpos anti-B. canis e anti-E. canis e detecção molecular de Babesia canis e Ehrlichia canis. Os resultados mostraram que dentre as 91 amostras testadas, 4% e 5% delas apresentaram E. canis e B. canis, respectivamente nas pesquisas parasitológicas dos esfregaços sanguíneos. Nas mesmas amostras, 82% e 51% delas apresentaram anticorpos anti-E. canis e anti-B. canis, respectivamente e, em 40% e 5%, foram detectados os DNA de E. canis e de B. canis, respectivamente. Os amplicons foram confirmados por seqüenciamento e o DNA de E. canis e de B. canis obtidos mostraram similaridade genética de 98% a 99% com amostras de E. canis e de B. canis isoladas em outros países, as árvores filogenéticas dos agentes pesquisados foram
Canine babesiosis and ehrlichiosis are common diseases in dogs, and are transmitted by the vector Rhipicephalus sanguineus. The clinical signs of these diseases are not specific. Detection of parasites in blood smears is not always possible and the serological detection could only indicate that the animal has had contact with the agent and not necessarily that the disease is being developed. In Colombia, there are few reports on canine babesiosis and ehrlichiosis´s epidemiology and diagnosis, being them based only on the detection of haemoparasites in blood smears and detection of antibodies. The purpose of the present study was to investigate the presence of Ehrlichia sp. and Babesia sp. in blood smears, associated with serological and molecular detection of these parasites in dog blood samples from the middle east region of Colombia. Blood and sera samples from 91 dogs from Bogotá (n=21), Villavicencio (n=31) and Bucaramanga cities (n=39) were submitted to parasitological, serological and molecular detection of B. canis and E. canis. Among the 91 samples tested, 4% and 5% presented E. canis morulae and B. canis piroplasms in blood smears, respectively. Moreover, 82% and 51% of samples presented antibodies anti-E. canis and anti-B. canis, respectively. E. canis and B. canis DNA were detected in 40% and 5% of samples, respectively. The amplicons were confirmed by sequencing and the found DNA from E. canis and B. canis showed a genetic identity of 98% to 99% among samples from E. canis and B. canis isolated from other countries. Finally, phyllogenetic trees were constructed from both agents
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Silva, Daniela. « Babesiose canina ». Master's thesis, Universidade de Évora, 2012. http://hdl.handle.net/10174/9137.

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O relatório de estágio de Mestrado Integrado em Medicina Veterinária, aqui apresentado, encontra-se dividido em duas secções. A primeira corresponde à descrição das atividades médico-veterinárias desenvolvidas ao longo do estágio curricular e a segunda secção corresponde à revisão bibliográfica de babesiose canina. O estágio foi realizado no Hospital Animal do Sul, situado em Faro e abrangeu a área de medicina interna e cirurgia de animais de companhia. A revisão bibliográfica é seguida do relato e discussão de um caso clínico de babesiose não complicada, acompanhado durante o período de estágio. A babesiose canina faz parte das doenças transmitidas por vetores com grande importância mundial e, apesar de ainda não estarem descritos casos humanos provocados por espécies de Babesia responsáveis por doença em cães, existem outros fatores que devem ser tidos em conta na análise da babesiose canina como uma futura potencial zoonose; Abstract Canine Babesiosis This report of Integrated Masters Degree in Veterinary Medicine, here presented, is divided into two sections. The first one corresponds to the description of medicalveterinary activities developed throughout the internship and the second one corresponds to a literature review on canine babesiosis. The internship was perfomed in Hospital Animal do Sul, in Faro and has as main areas of interest internal medicine and surgery of domestic animals. The literature review is followed by a presentation and discussion of a case-report of a uncomplicated babesiosis case, followed during the internship period. Canine babesiosis is one of vector-borne diseases of worldwide importance and, although human cases caused by species of Babesia responsible for disease in dogs, haven’t been reported, there are other factors that should be considered in the analysis of canine babesiosis as a future potential zoonosis.
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Henriques, Marcelo de Oliveira. « Aspectos cl?nicos, laboratoriais e epidemiol?gicos da infec??o natural por Babesia equi (Laveran, 1901) em eq?inos da Academia Militar das Agulhas Negras ». Universidade Federal Rural do Rio de Janeiro, 2006. https://tede.ufrrj.br/jspui/handle/tede/913.

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This study was conducted with the purpose to evaluate the clinical, laboratory and epidemiological aspects of naturally acquired Babesia equi infection in 178 horses handled in a semi-intensive system, property of the Academia Militar das Agulhas Negras Brazilian Army, situated in the city of Resende, in the Rio de Janeiro State. Babesia equi is a species of hemoparasite of elevated prevalence among equids in tropical regions, being hard to control, causing important economic losses because of the long periods of convalescence, decline of performance in the affected animals, expenses with medication and workers, besides the restrictions in transit of equines, either for hippic competitions or international commerce. In the Indirect Immunofluorescence Reaction, a prevalence of 85,96% (n=153) was verified, therefore the area can be considered endemic for Babesia equi and in enzootic stability. There was no significant difference in the age or sex of the seropositive animals. Laboratory parameters like packed cell volume, red blood cell count, platelet count, global and differential white blood cell counts, dosages of seric creatinine, albumin and total plasmatic proteins, all of which led to the conclusion that in the assymptomatic carrier state there is no hematologic or seric biochemical variations that could be attributed to the protozoal Babesia equi.
Este estudo foi conduzido com o intuito de avaliar achados cl?nicos, laboratoriais e epidemiol?gicos na infec??o natural de Babesia equi em 178 eq?inos mantidos em sistema semiintensivo de cria??o, de propriedade da Academia Militar das Agulhas Negras Ex?rcito Brasileiro, situada no munic?pio de Resende, Estado do Rio de Janeiro. Babesia equi ? uma esp?cie de hemoparasita de elevada preval?ncia entre eq??deos de ?reas tropicais, sendo de dif?cil controle, causando perdas econ?micas importantes, pelos longos per?odos de convalescen?a, queda de desempenho nos animais acometidos, gastos com medicamentos e m?o de obra, al?m de impor restri??es no tr?nsito de eq?inos, seja para competi??es h?picas ou com?rcio internacional. Na Rea??o de Imunofluoresc?ncia Indireta, foi verificada uma preval?ncia de 85,96% (n=153), podendo ser a ?rea considerada end?mica para Babesia equi e em estabilidade enzo?tica, n?o sendo observadas diferen?as significativas entre sexo e idade dos animais. Par?metros laboratoriais como volume globular, hematimetria, plaquetometria, leucometrias global e espec?fica, dosagens de creatinina s?rica, albumina e prote?nas plasm?ticas totais foram conduzidos, podendo-se concluir que no estado de portador assintom?tico n?o h? varia??o hematol?gica ou de bioqu?mica s?rica que possa ser creditada ao protozo?rio Babesia equi.
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Silva, Inês Picanço Castanheira da. « Estudo de hemoparasitas transmitidos por vectores, em cães de canil, Setúbal, Portugal ». Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2011. http://hdl.handle.net/10400.5/3543.

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Dissertação de Mestrado Integrado em Medicina Veterinária
As doenças transmitidas por vectores são causadas por parasitas, bactérias ou vírus e são veiculadas pela picada de artrópodes (principalmente ixodídeos e mosquitos). Estas doenças afectam cães a nível mundial e a maioria delas têm potencial zoonótico. Nestas estão incluídas as doenças sob estudo: Erliquiose, Babesiose, Riquetsiose, Anaplasmose e Leishmaniose. A patogénese das doenças sob estudo, baseia-se fundamentalmente na resposta humoral exagerada e não protectora desenvolvida pelo hospedeiro, que provoca sintomas semelhantes aos de uma doença auto-imune. Isto é, ao contrário do que se podia pensar, não é o parasita em si que é responsável por todos os sintomas da doença, mas sim a resposta imunológica do hospedeiro à sua presença. No que respeita ao diagnóstico, os médicos veterinários podem ter a sua tarefa complicada devido à ausência de sintomas específicos e à presença de co-infecções (infecção por mais do que um parasita). A compreensão por parte do clínico, da patogenia e imunologia das doenças transmitidas por vectores, é uma ferramenta essencial para o diagnóstico rápido e preciso. Sob o ponto de vista zoonótico, se por um lado os canídeos actuam como sentinelas de doenças, por outro, são reservatórios de parasitas e importantes hospedeiros de transporte de vectores. Devido a isto um dos pontos fulcrais da prevenção destas hemoparasitoses é o controlo de vectores. Neste estudo foi realizado o rastreio de cinco doenças transmitidas por vectores, causadas pelos agentes: Ehrlichia canis, Anaplasma phagocytophilum, Rickettsia conorii, Babesia canis e Leishmania infantum. Este estudo incidiu sobre uma população de um canil de Setúbal, no qual foram testados 80 cães (29 machos e 51 fêmeas) escolhidos aleatoriamente. Os testes utilizados foram testes comerciais de imunofluorescência indirecta (IFI). Dos animais testados 58,75% dos animais encontravam-se infectados (20% co-infectados e 38,75% mono-infectados). As prevalências de anticorpos contra os 5 agentes foram: Rickettsia conorii (23,75%), Babesia canis (20%), Ehrlichia canis (16,25%), Leishmania infantum (16,25%) e Anaplasma phagocytophilum (12,5%).
ABSTRACT - Vector-borne diseases in kennel dogs, a study - Vector-borne diseases are caused by parasites, virus and bacteria, and transmitted through the bite of arthropods. These diseases have a great zoonotic potential and affect dogs worldwide. The five diseases studied (Ehrlichiosis, Babesiosis, Rickettsiosis, Anaplasmosis and Leishmaniasis) are included in this category of illness. The pathogenesis, it‘s based mainly on the humoral response developed by the host, that being exaggerated and not protective, causes symptoms similar to an autoimmune disease. Meaning, on the contrary to what might be thought, is not the parasite itself that is responsible for all the symptoms, but the host‘s immune response to their presence. Concerning the diagnosis, veterinarians can have their task complicated by the absence of specific symptoms and the presence of co-infection (infection for more than a parasite).The understanding of the clinical, the pathogenesis and immunology of vector-borne diseases, is an essential tool for rapid and accurate diagnosis. From the zoonotic point of view, dogs act as sentinels of disease, and are important reservoirs of parasites and carry vectors. Due to this, one of the key points for prevention of vector-borne diseases in animals and humans is vector control. In this study was performed the screening of five vector-borne diseases caused by the agents: Ehrlichia canis, Anaplasma phagocytophilum, Rickettsia conorii, Babesia canis and Leishmania infantum. This study focused on a population of a kennel of Setúbal, in which 80 dogs (29 males and 51 females), randomly chosen, were tested. The tests used were indirect fluorescence antibody (IFA) commercial. 58.75% of the animals tested animals were infected (20% co-infected and 38.75% single infections). The point prevalence for different pathogens was: Rickettsia conorii (23.75%), Babesia canis (20%), Ehrlichia canis (16.25%), Leishmania infantum (16.25%) and Anaplasma phagocytophilum (12.5%).
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Araújo, Sara Alexandra Meireles da Costa. « Estudo de babesiose e leishmaniose nos cães dos concelhos de Lamego, Tarouca e Peso da Régua, Portugal ». Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/14514.

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Dissertação de Mestrado Integrado em Medicina Veterinária
Este estudo foi realizado com os seguintes objetivos: a) compreender a ocorrência de Babesiose Canina (BC) e Leishmaniose Canina (LCan) nos cães nos concelhos de Lamego, Tarouca e Peso da Régua; b) avaliar o risco de contacto dos cães com os vetores; c) analisar as medidas profiláticas instituídas nos animais amostrados. Para obtermos informação sobre as características da vida dos animais foi realizado um inquérito aos proprietários dos animais. Ao todo foram preenchidos 60 inquéritos (1 por animal). A amostra de 60 animais foi constituída por 32 cães diagnosticados com BC e 28 cães que foram submetidos a diagnóstico, rastreio ou avaliação do controlo de LCan. Relativamente aos animais amostrados para BC, verificámos que 100% dos animais foram positivos a Babesia spp, enquanto 60,7% dos cães amostrados para LCan foram positivos para Leishmania sp. O diagnóstico de BC foi realizado através da visualização de formas intraeritrocitárias de Babesia spp. no esfregaço sanguíneo dos 32 animais. Os testes utilizados para diagnóstico, rastreio e controlo de LCan variaram entre o método de ELISA e um teste imunocromatográfico. O teste de ELISA foi utilizado em 71,4% da população amostrada ao passo que o teste imunocromatográfico foi empregue em 28,6% dos cães. Relativamente às duas doenças estudadas verificámos que 56,3% dos animais amostrados para BC eram provenientes do concelho de Lamego, ao passo que 42,9% dos animais estudados para LCan pertenciam ao concelho do Peso da Régua. O estudo decorreu entre o dia 5 de setembro de 2016 e 28 de fevereiro de 2017, e verificámos que novembro de 2016 foi o mês em que se realizaram mais diagnósticos de BC, enquanto fevereiro de 2017 foi o mês em que se realizaram mais testes para diagnóstico, rastreio ou controlo de LCan. Alguns dos factores estudados para avaliar o risco de contacto com os vetores das respetivas doenças foram: a aptidão do animal, local onde dormem, convivência com cães diagnosticados com BC e LCan, acesso ao exterior das habitações, entre outros. Para análise da profilaxia dos animais comparámos a frequência utilizada com a recomendada pelo fabricante dos respetivos produtos. Assim dos 32 animais amostrados para Babesiose Canina verificámos que nenhum dos animais estava corretamente desparasitado, ao passo que apenas 39,3% dos animais testados para LCan apresentavam proteção correta para ectoparasitas.
ABSTRACT - Babesiosis and Leishmaniaosis study in domestic canids from the counties of Lamego, Tarouca and Peso da Régua, Portugal. - This study was accomplished based on the following goals: a) understand the occurrence of Canine Babesiosis (CB) and Canine Leishmaniasis (CanL) in domestic canids from the counties of Lamego, Tarouca and Peso da Régua; b) assess the risk of contact with the vectors; c) to analyse the prophylactic measures established in the sampled animals. In order to obtain information about the characteristics of the animals’ life, a survey was performed with the dog owners, resulting in 60 fulfilled inquiries, one per animal. This sample was constituted by 32 canids diagnosed with CB and 28 canids subbmited to a CanL diagnosis, survey and control assessment. Concerning the animals sampled for CB, we verified that 100% of the animals were positive to Babesia spp, while 60.7% of the dogs sampled to CanL were positive for Leishmania sp.. The CB diagnosis was performed using visualisation of intra-erythrocyte forms of Babesia spp. in the blood smear of the 32 animals. The tests used for the CanL diagnosis, survey and control assessment varied between the ELISA’s method and an immunochromatographic test. The first was used in 71,4% of the samples population and the second in 28,6% of the canids. Regarding the two studied diseases, we found that 56,3% of the CB samples animals originated from the county of Lamego whilst 42,9% of the CanL sampled animals belonged to the Peso da Régua county. The study was conducted between 5th September 2016 and 28th February 2017, and we verified that November 2016 was the month with more CB diagnosis, while February 2017 was the month in which more CanL diagnosis tests, survey and control assessment were performed. Some of the factors studied to assess the risk of contact with the vectors concerning these diseases were: the aptitude of the animal, the place where they slept, the coexistence with canids diagnosed with CB and CanL, the access to the outside of dwellings, among others. After analysing the animals prophylaxis, we compared the frequency used with the one recommended by the manufacturers of the respective products. Thus, among the 32 canine Babesiosis sampled animals we verified that none of those animals were properly dewormed, whilst only 39,3% of the CanL tested animals showed a correct protection regarding ectoparasites.
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Vargas, Hernández Giovanni. « Detecção parasitológica, molecular e sorológica de Erlichia canis e babesia canis em cães da região Centro-Oriental da Colômbia / ». Jaboticabal : [s.n.], 2010. http://hdl.handle.net/11449/89197.

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Orientadora: Mirela Tinucci Costa
Banca: Gervásio Henrique Bechara
Banca: Paulo Cesar Ciarlini
Resumo: A babesiose e a erliquiose canina são doenças comuns em cães, transmitidas pelo vetor Rhipicephalus sanguineus. Os sinais e sintomas dessas doenças não são específicos. A detecção dos parasitos em esfregaços sanguíneos nem sempre é possível e a detecção sorológica pode indicar apenas que o animal teve contato com o agente, mas não necessariamente a doença ativa. Na Colômbia existem poucas pesquisas sobre a epidemiologia e diagnóstico de erliquiose e babesiose em cães, as poucas existentes se basearam na detecção dos hemoparasitas em esfregaços sanguíneos, ou de anticorpos específicos. Sendo assim propos-se este estudo com o objetivo de pesquisar a erliquiose e a babesiose em esfregaços sangüíneos associados a provas sorológicas e moleculares em cães da região centro-oriental de Colômbia. Amostras de sangue e soro de 91 cães, provenientes das cidades de Bogotá (n=21), Villavicencio (n=31) e Bucaramanga (n=39) foram submetidas a pesquisa parasitológica, detecção de anticorpos anti-B. canis e anti-E. canis e detecção molecular de Babesia canis e Ehrlichia canis. Os resultados mostraram que dentre as 91 amostras testadas, 4% e 5% delas apresentaram E. canis e B. canis, respectivamente nas pesquisas parasitológicas dos esfregaços sanguíneos. Nas mesmas amostras, 82% e 51% delas apresentaram anticorpos anti-E. canis e anti-B. canis, respectivamente e, em 40% e 5%, foram detectados os DNA de E. canis e de B. canis, respectivamente. Os amplicons foram confirmados por seqüenciamento e o DNA de E. canis e de B. canis obtidos mostraram similaridade genética de 98% a 99% com amostras de E. canis e de B. canis isoladas em outros países, as árvores filogenéticas dos agentes pesquisados foram
Abstract: Canine babesiosis and ehrlichiosis are common diseases in dogs, and are transmitted by the vector Rhipicephalus sanguineus. The clinical signs of these diseases are not specific. Detection of parasites in blood smears is not always possible and the serological detection could only indicate that the animal has had contact with the agent and not necessarily that the disease is being developed. In Colombia, there are few reports on canine babesiosis and ehrlichiosis's epidemiology and diagnosis, being them based only on the detection of haemoparasites in blood smears and detection of antibodies. The purpose of the present study was to investigate the presence of Ehrlichia sp. and Babesia sp. in blood smears, associated with serological and molecular detection of these parasites in dog blood samples from the middle east region of Colombia. Blood and sera samples from 91 dogs from Bogotá (n=21), Villavicencio (n=31) and Bucaramanga cities (n=39) were submitted to parasitological, serological and molecular detection of B. canis and E. canis. Among the 91 samples tested, 4% and 5% presented E. canis morulae and B. canis piroplasms in blood smears, respectively. Moreover, 82% and 51% of samples presented antibodies anti-E. canis and anti-B. canis, respectively. E. canis and B. canis DNA were detected in 40% and 5% of samples, respectively. The amplicons were confirmed by sequencing and the found DNA from E. canis and B. canis showed a genetic identity of 98% to 99% among samples from E. canis and B. canis isolated from other countries. Finally, phyllogenetic trees were constructed from both agents
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Cavalcante, Gustavo Góes. « Aspectos clínicos e epidemiológicos das infecções por Babesia bovis, Babesia bigemina e Anaplasma marginale em bezerros da raça Nelore no Estado de São Paulo / ». Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/101292.

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Orientador: Teresa Cristina Goulart de Oliveira Sequeira
Banca: Claudio Roberto Madruga
Banca: Márcia Cristina Sena de Oliveira
Banca: Lúcia Helena O'Dwyer
Banca: Agueri Kohayagawa
Resumo: A dinâmica das infecções naturais por Babesia bovis, Babesia bigemina e Anaplasma marginale, foi investigada ao longo do primeiro ano de vida de bezerros da raça Nelore criados em sistema extensivo no Estado de São Paulo, com o propósito de se avaliar a influência da criação exclusiva e extensiva de bovinos da raça Nelore sobre a epidemiologia desses hemoparasitas. Amostras de sangue de 17 animais P.O. foram colhidas a cada 15 dias do nascimento até os quatro meses, e então, a cada 30 dias até um ano. Amostras de sangue colhidas da ponta da orelha foram utilizadas para a confecção de esfregaços sanguíneos, e amostras de sangue da veia jugular foram utilizadas para a determinação da contagem total de eritrócitos (RBC), concentração de hemoglobina (HB), volume globular (VG), contagem total de leucócitos (CTL) e extração de DNA. As teleóginas colhidas foram incubadas em estufa BOD e posteriormente submetidas ao processo de extração de DNA. A amplificação do DNA dos hemoparasitas foi feita pelas técnicas de PCR e nPCR, utilizando-se respectivamente os primers BoF e BoR; BoFN e BoRN para Babesia bovis, BiIA e BilB; BilAN e BilBN para B. bigemina e Am9 e Am10; Am11 e Am12 para A. marginale. Ao longo de um ano de experimento não foram observados casos clínicos de tristeza parasitária, e os quatro animais em que parâmetros hematológicos indicativos de anemia foram detectados concomitantemente com uma ou mais espécies de hemoparasitas se recuperaram sem que houvesse necessidade de tratamento. Babesia bovis não foi detectada nos esfregaços sangüíneos corados por Giemsa, porém merozoítas de B. bigemina foram encontrados em 5 amostras de sangue provenientes de 4 animais. Corpúsculos intraeritrocitários de A. marginale foram detectados em 29 amostras oriundas de 14 animais, nas quais a mais elevada taxa de parasitemia foi de 26%... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The dynamics of natural Babesia bovis, Babesia bigemina and Anaplasma marginale infection was investigated along the first year of Nelore calves, raised on extensive system in São Paulo State. The purpose was to evaluate the influence of the exclusive and extensive breeding of Nelore bovine on the epidemiology of those hemoparasites. Blood samples of 17 purebred animals were harvested every 15 days beginning on the first day of birth till four months old, and then, every 30 days till one year old. Blood samples from the ear tip were used to made blood smears, and blood samples were taken from the jugular vein to determine the red blood cells total count (RBC), hemoglobin concentration (HB), haematocrite (VG), leukocytes total count (LTC) and DNA extraction. The engorged Boophilus microplus were incubated and submitted to the DNA extraction process. The hemoparasite DNA amplification was made by PCR and nPCR respectively, using the primers BoF and BoR; BoFN and BoRN for Babesia bovis, BiIA and BilB; BilAN and BilBN for B. bigemina and Am9 and Am10; Am11 and Am12 for A. marginale. Clinical cases of parasitic sickness were not observed along one year of experiment. The four animals that were observed with indication of anemia hematological parameters, detected at the same time with one or more hemoparasites species, recovered without treatment. Babesia bovis was not detected in the blood smears. However, B. bigemina merozoites were found in five blood samples coming from four animals. A. marginale was detected in 29 blood samples of 14 animals, in which the highest parasitemia level was 26%. The reactions of PCR and nPCR revealed the presence of B. bovis DNA in seven blood samples (four by PCR) from three animals, one of them born in less than 24 hours... (Complete abstract, access undermentioned electronic address)
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MISCHEL, ISABELLE. « La babesiose humaine ». Strasbourg 1, 1992. http://www.theses.fr/1992STR15037.

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Livres sur le sujet "Babesiosi"

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1954-, Větvička Václav, dir. Immunology of annelids. Boca Raton, FL : CRC Press, 1994.

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C, Fisher Rita, Anaplasmosis Babesiosis Network (U.S.) et United States. Agency for International Development. Office of Agriculture., dir. Anaplasmosis/babesiosis bibliography 1991. Pullman, Wash : Anaplasmosis/Babesiosis Network, International Development Cooperation Office, Washington State University, 1992.

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C, Fisher Rita, Anaplasmosis Babesiosis Network (U.S.) et United States. Agency for International Development. Office of Agriculture., dir. Anaplasmosis/babesiosis bibliography 1992. Pullman, Wash : Anaplasmosis/Babesiosis Network, International Development Cooperation Office, Washington State University, 1992.

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C, Fisher Rita, Anaplasmosis Babesiosis Network (U.S.) et United States. Agency for International Development. Office of Agriculture., dir. Anaplasmosis, babesiosis bibliography 1990. Pullman, Wash : Anaplasmosis/Babesiosis Network, International Project Support Office, Washington State University, 1991.

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C, Fisher Rita, Anaplasmosis Babesiosis Network (U.S.) et United States. Agency for International Development. Office of Agriculture., dir. Anaplasmosis, babesiosis bibliography 1977-87. Pullman, Wash. USA : Anaplasmosis/Babesiosis Network, International Project Support Office, Washington State University, 1989.

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1918-, Ristic Miodrag, dir. Babesiosis of domestic animals and man. Boca Raton, Fl : CRC Press, 1988.

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1918-, Ristic Miodrag, dir. Babesiosis of domestic animals and man. Boca Raton, Fla : CRC Press, 1988.

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Ireland. Food Safety Advisory Committee. Leptospiral infections, Lyme disease, Babesiosis, Orf virus disease. Dublin : Stationery Office, 1992.

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Selim, M. K. Survey, epidemiology and therapeutic studies on equine babesiosis in Egypt and its control : The final technical report, February 26, 1978 - to February 25, 1986. Cairo, Egypt : Animal Health Research Institute?, 1986.

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Controlling cattle fever ticks. Riverdale, Md.] : U.S. Dept. of Agriculture, Animal and Plant Health Inspection Service, 2010.

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Chapitres de livres sur le sujet "Babesiosi"

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Berry, Colin, Jason M. Meyer, Marjorie A. Hoy, John B. Heppner, William Tinzaara, Clifford S. Gold, Clifford S. Gold et al. « Babesiosis ». Dans Encyclopedia of Entomology, 345. Dordrecht : Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_200.

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Dantas-Torres, Filipe, Leucio Camara Alves et Gerrit Uilenberg. « Babesiosis ». Dans Arthropod Borne Diseases, 347–54. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-13884-8_21.

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Ruebush, Trenton K. « Babesiosis ». Dans Laboratory Diagnosis of Infectious Diseases, 784–86. New York, NY : Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3898-0_81.

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Schütt-Gerowitt, Heidi. « Babesiose ». Dans Lexikon der Infektionskrankheiten des Menschen, 56–59. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-39026-8_91.

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Dey, Jayanta Bikash. « Babesiosis ». Dans Textbook of parasitic zoonoses, 163–70. Singapore : Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7204-0_15.

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Gooch, Jan W. « Babesiosis ». Dans Encyclopedic Dictionary of Polymers, 876. New York, NY : Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13212.

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Lantos, Paul, et Peter J. Krause. « Babesiosis ». Dans World Class Parasites, 151–64. Boston, MA : Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-1123-6_9.

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Berry, Colin, Jason M. Meyer, Marjorie A. Hoy, John B. Heppner, William Tinzaara, Clifford S. Gold, Clifford S. Gold et al. « Bovine Babesiosis ». Dans Encyclopedia of Entomology, 552. Dordrecht : Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_423.

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Gabrys, Beata, John L. Capinera, Jesusa C. Legaspi, Benjamin C. Legaspi, Lewis S. Long, John L. Capinera, Jamie Ellis et al. « Canine Babesiosis ». Dans Encyclopedia of Entomology, 710. Dordrecht : Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_476.

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Homer, Mary J., et David H. Persing. « Human Babesiosis ». Dans Tick-Borne Diseases of Humans, 343–60. Washington, DC, USA : ASM Press, 2014. http://dx.doi.org/10.1128/9781555816490.ch20.

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Actes de conférences sur le sujet "Babesiosi"

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Taweesedt, P. T., E. Barca et R. Siegel. « Fatal Human Babesiosis ». Dans American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6931.

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Slipchenko, Victoria. « BABESIOSIS OF DOGS ». Dans THEORETICAL AND EMPIRICAL SCIENTIFIC RESEARCH : CONCEPT AND TRENDS. European Scientific Platform, 2021. http://dx.doi.org/10.36074/logos-10.12.2021.v1.44.

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Shah, N., T. Sharma, G. Manek, K. D. Stettmeier, D. Banach et D. Datta. « Severe Babesiosis at Delivery ». Dans American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6626.

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Slipchenko, Victoria. « PYROPLASMOSIS OR BABESIOSIS OF DOGS ». Dans MODALITĂȚI CONCEPTUALE DE DEZVOLTARE A ȘTIINȚEI MODERNE. European Scientific Platform, 2020. http://dx.doi.org/10.36074/20.11.2020.v2.41.

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Boykova, V. A. « BABEZIOSIS IN DOGS. CLINICAL CASE ». Dans DIGEST OF ARTICLES ALL-RUSSIAN (NATIONAL) SCIENTIFIC AND PRACTICAL CONFERENCE "CURRENT ISSUES OF VETERINARY MEDICINE : EDUCATION, SCIENCE, PRACTICE", DEDICATED TO THE 190TH ANNIVERSARY FROM THE BIRTH OF A.P. Stepanova. Publishing house of RGAU - MSHA, 2021. http://dx.doi.org/10.26897/978-5-9675-1853-9-2021-27.

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Izakovich, T., A. Adial, A. Iftikhar, M. A. Cheema et J. M. Mann. « Severe Babesiosis with Low Levels of Parasitemia ». Dans American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6554.

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Singh, Pahul P., Subhraleena Das, Sujith V. Cherian, Pranav Singh et Robert Lenox. « Adult Respiratory Distress Syndrome Secondary To Babesiosis ». Dans American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5957.

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Helm, C., C. Weingart, I. Schäfer, S. Pachnicke, E. Müller, G. von Samson-Himmelstjerna, J. Krücken et B. Kohn. « Kanine Babesiose – 15 autochthone Fälle in Berlin/Brandenburg ». Dans 29. Jahrestagung der FG „Innere Medizin und klinische Labordiagnostik“ der DVG (InnLab) – Teil 2 : Poster. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1723887.

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Bilokur, Diana, et Victoria Gryshchenko. « AMINOTRANSFERASE ACTIVITY OF BLOOD PLASMA IN CANINE BABESIOSIS ». Dans DÉBATS SCIENTIFIQUES ET ORIENTATIONS PROSPECTIVES DU DÉVELOPPEMENT SCIENTIFIQUE. European Scientific Platform, 2021. http://dx.doi.org/10.36074/logos-05.02.2021.v3.01.

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Condit, D., C. Conner, J. J. Amja et R. Mutneja. « Babesiosis Induced Septic Shock in the Setting of Asplenia ». Dans American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6916.

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Rapports d'organisations sur le sujet "Babesiosi"

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McElwain, Terry, Eugene Pipano, Guy Palmer, Varda Shkap, Stephen Hines et Douglas Jasmer. Protection of Cattle Against Babesiosis : Immunization with Recombinant DNA Derived Apical Complex Antigens of Babesia bovis. United States Department of Agriculture, juin 1995. http://dx.doi.org/10.32747/1995.7612835.bard.

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Bovine babesiosis caused by Babesia bovis continues to be a significant deterrent to global livestock production. Current control methods have both biological and technical drawbacks that have stimulated research on improved methods of vaccination. This BARD project has focused on characterization of candidate Babesia bovis vaccine antigens located in the apical complex, a unique group of subcellular organelles - including rhoptries, micronemes, and spherical bodies - involved in the invation of erythrocytes. Spherical bodies and rhoptries were partially purified and their contents characterized using monoclonal antibodies. Existing and newly developed monoclonal antibodies bound to antigens in the spherical body, rhoptry, merozoite membrane, and infected erythrocyte membrane. In an initial immunization study using biologically cloned strains, it was demonstrated that strain-common epitopes are important for inducing immune protection against heterologous challenge. Rhoptry-associated antigen 1 (RAP-1) had been demonstrated previously to induce partial immune protection, fulfilled criteria of broad interstrain B and T cell epitope conservation, and thus was further characterized. The RAP-1 gene family consists of at least two gene copies, is homologous to the RAP-1 gene family in B. bigemina, and contains significant sequence similarity to other erythroparasitic protozoan candidate vaccine antigens, including the apical membrane antigen of Plasmodium falciparum. A new RAP-1 monoclonal antibody was developed that inhibits merozoite growth in vitro, demonstrating the presence of a RAP-1 neutralization sensitive domain. Based on these observations, cattle were immunized with Mo7 (Mexico) strain recombinant RAP-1 representing one of the two gene copies. All cattle responded with variable levels of serum antibodies inhibitory to heterologous Israel strain merozoite growth in vitro, and RAP-1 specific T lymphocytes that proliferated when stimulated with either homologous or heterologous native parasite antigen. Minimal protection from clinical disease was present after virulent Israel (heterologous) strain B. bovis challenge. In total, the results support the continued development of RAP-1 as a vaccine antigen, but indicate that additional information about the native structure and function of both RAP-1 gene copies, including the relationship of conserved and polymorphic sequences to B and T cell lepitopes relevant for protection, is necessary for optimization of RAP-1 as a vaccine component.
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McElwain, Terry F., Eugene Pipano, Guy H. Palmer, Varda Shkap, Stephn A. Hines et Wendy C. Brown. Protection of Cattle against Babesiosis : Immunization against Babesia bovis with an Optimized RAP-1/Apical Complex Construct. United States Department of Agriculture, septembre 1999. http://dx.doi.org/10.32747/1999.7573063.bard.

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Previous research and current efforts at control of babesiosis fall short of meeting the needs of countries where the disease is endemic, such as Israel, as well as the needs of exporting countries and countries bordering on endemic areas, such as the U.S. Our long-term goal is to develop improved methods of immunization against bovine babesiosis based on an understanding of the molecular mechanisms of immune protection and parasite targets of a protective immune response. In our previous BARD project, we established the basis for focusing on rhoptry antigens as components of a subunit vaccine against bovine babesiosis, and for additional research to better characterize rhoptry associated protein-1 (RAP-1) as a target of protective immunity. In this continuation BARD project, our objectives were to [1] optimize the immune response against RAP-1, and [2] identify additional rhoptry candidate vaccine antigens. The entire locus encoding B. bovis RAP-1 was sequenced, and the rap-1 open reading frame compared among several strains. Unlike B. bigemina, in which multiple gene copies with variant domains encode RAP-1, the B. bovis RAP-1 locus contains only two identical genes which are conserved among strains. Through testing of multiple truncated constructs of rRAP-1, one or more immunodominant T cell epitopes were mapped to the amino terminal half of RAP-1. At least one linear and one conformational B cell epitope have been demonstrated in the same amino terminal construct, which in B. bigemina RAP-1 also contains an epitope recognized by neutralizing antibody. The amine terminal half of the molecule represents the most highly conserved part of the gene family and contains motifs conserved broadly among the apicomplexa. In contrast, the carboxy terminal half of B. bovis RAP-1 is less well conserved and contains multiple repeats encoding a linear B cell epitope potentially capable of inducing an ineffective, T cell independent, type 2 immune response. Therefore, we are testing an amino terminal fragment of RAP-1 (RAP-1N) in an immunization trial in cattle. Cattle have beer immunized with RAP-1N or control antigen, and IL-12 with Ribi adjuvant. Evaluation of the immune response is ongoing, and challenge with virulent B. bovis will occur in the near future. While no new rhoptry antigens were identified, our studies did identify and characterize a new spherical body antigen (SBP3), and several heat shock proteins (HSP's). The SBP3 and HSP21 antigens stimulate T cells from immune cattle and are considered new vaccine candidates worthy of further testing. Overall, we conclude that a single RAP-1 vaccine construct representing the conserved amino terminal region of the molecule should be sufficient for immunization against all strains of B. bovis. While results of the ongoing immunization trial will direct our next research steps, results at this time are consistent with our long term goal of designing a subunit vaccine which contains only the epitopes relevant to induction of protective immunity. Parallel studies are defining the mechanisms of protective immunity. Apicomplexan protozoa, including babesiosis and malaria, cause persistent diseases for which control is inadequate. The apical organelles are defining features of these complex protozoa, and have been conserved through the evolutionary process, Past and current BARD projects on babesiosis have established the validity and potential of exploiting these conserved organelles in developing improved control methods applicable to all apicomplexan diseases.
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Knowles, Donald, et Monica Leszkowicz Mazuz. Transfected Babesia bovis expressing the anti-tick Bm86 antigen as a vaccine to limit tick infestation and protect against virulent challenge. United States Department of Agriculture, janvier 2014. http://dx.doi.org/10.32747/2014.7598160.bard.

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Bovine babesiosis, caused by the apicomplexan parasites Babesiabovisand B. bigemina, is a major tick borne disease of cattle with significant economic importance globally. The vectors of Babesia parasites are R. (Boophilus) annulatusand R. microplus. In Israel these parasites are transmitted manly by R. annulatus. The main goal of the proposal was developing and testing a novel B. bovisvaccine based on stably transfected attenuated B. bovisexpressing the anti-tick Bm86 antigen. This required generating a transfected- attenuated B. bovisparasite containing a bidirectional promoter expressing both, the gfp- bsd selectable marker and the tick vaccine antigen Bm86. The vaccine was tested for its ability to elicit protective immune responses against T. annulatusticks. Efficient control of babesiosis is based on a complex scheme of integrated management, including preventive immunization, anti-babesial chemotherapy and control of tick populations. Live vaccines based on attenuated parasites are the most effective measure to control babesiosis, and are currently used in several countries, including Israel. Live attenuated parasites lead to a chronic infection and development of strong and long term immunity in vaccinated cattle. Still, live vaccines have several limitations, including the difficulty to distinguish among vaccinated and naturally infected cattle and potential for sporadic outbreaks in vaccinated animals. Tick limitation is essential to control babesiosis but the main measure to reduce tick infestation is traditionally approached using acaricides, which is limited by environmental concerns and the development of resistance by the ticks. Alternative tick-control measures including the use of anti-tick vaccines are emerging, and at least partial protective immunity has been achieved against tick vectors by vaccination with recombinant protective tick antigens (ie: Bm86). In addition, the Babesia vaccine development toolbox has been recently expanded with the development of transfection technology in Babesia parasites. In this approved proposal we successfully developed a Babesia live attenuated transfected vaccine, which is able to express a B. bovisMSA-1 signal-Bm86 chimera and eGFP genes under the control of the B. bovisef- 1 and actin promoters respectively. Genetic analysis demonstrated specific stable integration of the transfected genes in the expected ef-1 locus, and immunofluorescence analysis confirmed expression of Bm86 in the surface of transfected parasites. When applied to splenectomized calves, the transfected parasites were able to cause persistent B. bovisinfection with production of antibodies reactive with Bm86 for at least six months. In addition, partial protection against ticks was also observed upon challenging the vaccinated animals with R. annulatuslarvae. However, when used on intact calves, the vaccine failed to elicit detectable immune responses against Bm86, and we are still in the process of interpreting the data and make necessary changes in our experimental approaches. Overall, the results obtained here represent a step forward towards the development of integrated vaccines against both ticks and tick –borne pathogens, using the Babesia attenuated parasites as a platform to the delivery of exogenous protective antigens
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