Thèses sur le sujet « Autoantigeni »
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AZZONI, ELISABETTA. « IDENTIFICAZIONE DI AUTOANTIGENI IN PATOLOGIE NEUROLOGICHE AUTOIMMUNI ». Doctoral thesis, Università degli studi di Trieste, 2005. http://hdl.handle.net/10077/14657.
Texte intégralRUSSO, LUCIA. « Ricerca di nuovi autoantigeni nel diabete di tipo 1:immunoproteomica delle isole pancreatiche umane ». Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/209587.
Texte intégralBlöcker, Inga-Madeleine. « Epitopmapping des epidermalen Autoantigens BP230 ». Lübeck Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1003311334/34.
Texte intégralSchumann, Frank. « Autoantigene bei der rheumatoiden Arthritis ». [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/199/index.html.
Texte intégralRaith, Albert Johann. « Charakterisierung des potenziellen Autoantigens cRALBP ». Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-47172.
Texte intégralFrazer, Hilary Elizabeth. « Autoantigens in connective tissue disease ». Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328058.
Texte intégralTengnér, Pia. « Immune responses to the Ro and La autoantigens / ». Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3590-4/.
Texte intégralMewar, Devesh. « Studies on autoantigens in rheumatoid arthritis ». Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/3455/.
Texte intégralIwobi, Mabel Uzoamaka. « Salivary autoantigens in human rheumatic diseases ». Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260048.
Texte intégralCiudad, García María Teresa. « Autoantigen Processing. How immunodominant thyroglobulin peptides are generated and presented by HLA-DR molecules ». Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/325144.
Texte intégralDCs are the most capable APCs, express all the necessary machinery and have a high capacity of efficient presentation. We have established that the peptidome from unpulsed professional APC can be studied without having to resort to cell lines, using small numbers of monocyte-derived DCs that tend to select very high-affinity peptides forming nested sets as a norm. However, they also presented unconventional peptides. 20% of the peptides presented by all alleles were N-terminal or C-terminal peptides. Most C-terminal peptides were located at the very extreme of the protein, pertained to cytosolic proteins and did not cluster in nested sets. They also show preferent cleavage residues, compared to internal peptides. We have used MoDCs and an in vitro digestion model set up as a cell-free system (CFS) to analyze the processing and presentation of an AITD autoantigen, thyroglobulin. Native or denatured purified thyroglobulin captured by MoDC generated many peptides, with dominant nested sets and no peptide derived from the N- or C-terminus of the protein. Very similar pattern was obtained wen MoDC were pulsed with colloid-enriched thyroid tissue extracts. Yet, if thyroglobulin was digested by the colloid cathepsins (B, L and S) at pH 7.4 prior to pulsing, MoDCs presentation of thyroglobulin peptides was almost completely abrogated. The large amount of intact thyroglobulin in the tissue extract could be accountable for these data and that the pre-digestion must have destroyed any thyroglobulin epitope that could be presented. However, when we did the same experiment using the CFS, predigested thyroglobulin was as efficiently presented as purified protein. Therefore, pre-digestion did not destroy epitopes, the fragments may have been degraded before reaching the MIIC in MoDCs. Thus, the state of the antigen is extremely relevant for its presentation by MoDCs but, the CFS method may help identifying steps of the processing events that may be lost when analyzing DC-presented peptides. Two abundant and high affinity dominant nested sets were identified from thyroglobulin. One, associated to HLA-DR3 with the VVVDPSIRH core and one associated to HLA-DR15 with the core IMQYFSHFI. The VVVDPSIRH set contains peptide Tg2098, defined as immunodominant in an in vivo model of thyroiditis in HLA-DR3 transgenic mice. The same peptide was identified in the HLA-DR3+ peptidome from GD patients' thyroids. HLA-DR15 is not negatively associated to AITD but in a similar model, HLA-DR15 transgenic mice did not develop the disease using the same conditions. Interestingly, in HLA-DR15/DR3 MoDCs, most thyroglobulin peptides were presented by HLA-DR15 but peptides with this core were not identified in HLA-DR15+ thyroid samples affected by GD. A second nested set associated to HLA-DR3 was also found, independent of the source of antigen or the processing method. This second HLA-DR3 nested set, around the VIFDANAPV core, was not as abundant as the VVVDPSIRH and contained a peptide (Tg1574), known not to generate T cell responses in the same EAT model as the Tg2098 peptide. The functional difference between these two peptides correlated with two characteristics that are important in the definition of immunodominance, i.e. sensitivity to cathepsins and to HLA-DM. Tg1574 was cathepsin-resistant whereas Tg2098 was partially sensitive. Upon digestion with several combinations of cathepsins, Tg1574 did not generate any intermediate variants and between 45 and 100% remained intact. In contrast, Tg2098 was trimmed at the peptide ends generating a number of variants, its core was maintained resistant to cleavage and only between 6 and 26% remained intact. In addition, Tg1574 was much more sensitive to HLA-DM than Tg2098. Interpreting these data after identifying what of the two peptides is preferentially presented in thymus will be necessary to fully demonstrate our hypothesis.
Welin, Henriksson Elisabet. « Autoantigenic properties of the U1-70K protein / ». Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2818-5/.
Texte intégralLundberg, Karin. « Arthritogenic and immunogenic properties of modified autoantigens / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-303-5/.
Texte intégralMulcahy, Anthony Francis. « The molecular cloning and characterisation of autoantigens ». Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242453.
Texte intégralRiemekasten, Gabriela. « Die Rolle eines SmD1Peptids bei der Entstehung von pathogenetisch bedeutsamen Autoantikörpern beim systemischen Lupus erythematodes ». Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/13858.
Texte intégralMorgan, James. « Analysis of candidate retinal autoantigens in autoimmune uveitis ». Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415718.
Texte intégralGramaglia, Irene. « MHC mimicry with autoantigens : possible role in autoimmunity ». Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244691.
Texte intégralNeophytou, Pavlos Ioanni. « Approaches to the cloning of beta-cell autoantigens ». Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339471.
Texte intégralNandedkar, Neha Dhananjay. « Autoantigens and Insulin Receptor in Type 1 Diabetes ». University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556215572248676.
Texte intégralBlöcker, Inga-Madeleine [Verfasser]. « Epitopmapping des epidermalen Autoantigens BP230 / Inga-Madeleine Blöcker ». Lübeck : Zentrale Hochschulbibliothek Lübeck, 2010. http://d-nb.info/1003311334/34.
Texte intégralHu, Hong-gang. « Das Protein DEK im Chromatin menschlicher Zellen ». Aachen Shaker, 2005. http://d-nb.info/988919354/04.
Texte intégralMcKee, Hayley Jane. « Aggrecan as a candidate autoantigen in rheumatoid arthritis ». Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323445.
Texte intégralSchubert, David. « Arthritisinduktion durch Immunität gegen ein systemisch exprimiertes Autoantigen ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15271.
Texte intégralAbout 1% of the of the population of the western world suffers from rheumatoid arthritis (RA). In a T-cell receptor transgenic mouse model, the K/BxN model, the ubiquitously expressed glucose-6-phosphate isomerase (G6PI) is recognized by autoreactive T- and B-cells. These mice do develop an antibody dependent arthritis which show a lot of features of human RA. In this study it was examined whether arthritis could be induced in normal non-transgenic mice by immunization with G6PI. Immunization with heterologous human G6PI induces a symmetric polyarthritis in over 95% of DBA/1 mice. Therewith showing for the first time that an immune reaction against an systemic expressed antigen will lead to the development of an organ specific disease in normal non-transgenic mice. The mice develop arthritis 9d after immunization, reach their maximum at d15 and then arthritis slowly resolve. Histologically, the disease is characterized by early synovitis followed by massive cartilage destruction and erosions of the bones and later repair processes including fibrosis. Although antibody titers in the mice are high, transfer of purified anti-G6PI antibodies of sick mice alone do not transfer disease. Anyway, antibodies seem to play a major role since FcR-gamma-chain deficient mice develop disease with a much lower frequency and reduced severity. Depletion of CD4 positive T cells completely prevents disease and depletion during disease leads to an rapid resolution of arthritis. Aside this, complement and TNF-alpha is critical for the development of arthritis, which could shown by depletion of C5 and blockade of TNF-alpha. In addition, the role of G6PI in the pathogenesis of RA in humans was examined. RA patients do not show a higher frequency of CD4 positive T-cells which produce TNF-alpha and IFN-gamma after restimulation with G6PI. Furthermore, no elevated anti-G6PI titers could be detected in RA patients and in patients with other rheumatic diseases.
Berger, Sara Maria Luginbühl Sarah. « Strukturelle und funktionelle Gemeinsamkeiten von Autoantigenen / ». [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000279107.
Texte intégralArdesjö, Brita. « Autoantigens in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis ». Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8677.
Texte intégralZhu, Jianhui. « Induction of the cellular expression of human Ro autoantigens ». Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39900.
Texte intégralSchirmer, Jan Henrik [Verfasser], et Friedrich [Akademischer Betreuer] Haag. « Charakterisierung putativer humaner Autoantigene / Jan Henrik Schirmer. Betreuer : Friedrich Haag ». Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1025150910/34.
Texte intégralHärkönen, Taina. « Cross-reactive immune responses between enteroviruses and islet cell autoantigens ». Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/harkonen/.
Texte intégralDuan, Fei. « Immune rejection of mouse tumors expressing mutated self / ». Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1432805051&sid=8&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Texte intégralSchmalzl, Thomas Benedikt. « Charakterisierung des Autoantigens "mitochondriale Malat-Dehydrogenase" bei der equinen rezidivierenden Uveitis ». Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-36151.
Texte intégralEkwall, Olov. « Pteridine dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1 ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4941-7/.
Texte intégralArif, Sefina. « Autoantibodies and autoantigens in type 1 diabetes and premature ovarian failure ». Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285177.
Texte intégralChung, Chen-Yen. « CD4+ T cell responses to myelin autoantigens : activation, memory and tolerance ». Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4013.
Texte intégralBourquin, Carole. « Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis ». Diss., lmu, 2000. http://nbn-resolving.de/urn:nbn:de:bvb:19-106.
Texte intégralOttosson, Lars. « Molecular characterization of the Ro52 autoantigen and its disease related epitopes / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-185-7/.
Texte intégralDavies, Marie Louise. « Autoantigen specific T cell responses in relation to systemic lupus erythematosus ». Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394161.
Texte intégralMacdonald, Pamela. « The role of apoptosis in autoantigen presentation during primary biliary cirrhosis ». Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405349.
Texte intégralWhitehead, Clark Merrill. « The identification and characterization of two human autoantigens, HsEg5 and ASE-1 ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0027/NQ49554.pdf.
Texte intégralAl-bukhari, Talat Abdullah. « Investigation of the epitope specificities of antibodies to islet β-cell autoantigens ». Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/13868/.
Texte intégralDromey, James Anthony. « Lymphocytes and the autoimmune response to islet autoantigens in Type 1 diabetes ». Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400496.
Texte intégralTremble, Jennifer Margaret. « Cellular and humoral responses to islet cell autoantigens in insulin dependent diabetes ». Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286687.
Texte intégralPAILLARD-COURTIN, SOPHIE. « Etude du mecanisme d'interaction de la proteine ku, autoantigene nucleaire, avec l'adn ». Paris 7, 1992. http://www.theses.fr/1992PA077146.
Texte intégralFranke, Claudia. « Das Protein La/SS-B : Vom Autoantigen zur Zielstruktur für die Immuntherapie ». Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-27655.
Texte intégralLocke, James. « The role of joint-associated autoantigen-specific immune responses in rheumatoid arthritis ». Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1773.
Texte intégralFalconer, Jane. « T cell recognition of proteoglycan aggrecan : a candidate autoantigen in inflammatory arthritis ». Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525062.
Texte intégralFranke, Claudia. « Das Protein La/SS-B : Vom Autoantigen zur Zielstruktur für die Immuntherapie ». Doctoral thesis, Technische Universität Dresden, 2009. https://tud.qucosa.de/id/qucosa%3A25267.
Texte intégralSanati, Mohammad Hossein. « Cloning and characterisation of a novel mitochondrial autoantigen associated with multiple sclerosis ». Thesis, Sanati, Mohammad Hossein (1996) Cloning and characterisation of a novel mitochondrial autoantigen associated with multiple sclerosis. PhD thesis, Murdoch University, 1996. https://researchrepository.murdoch.edu.au/id/eprint/52268/.
Texte intégralBuse, Barbara Christina. « Identifikation von sechs potenziellen Autoantigenen bei Hunden mit dilatativer Kardiomyopathie ». Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-72257.
Texte intégralLapointe, Elvy. « Caractérisation du système autoantigène/autoanticorps Sa dans la polyarthrite rhumatoïde ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/MQ56925.pdf.
Texte intégralLapointe, Elvy. « Caractérisation du système autoantigène/autoanticorps Sa dans la polyarthrite rhumatoïde ». Sherbrooke : Université de Sherbrooke, 2000.
Trouver le texte intégralNguyen, Thi Bang Tam. « Regulation der Genexpression des Diabetes-assoziierten Autoantigens IA-2 in INS-1 Betazellen ». [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966456009.
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