Littérature scientifique sur le sujet « Atropisomerismo »
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Articles de revues sur le sujet "Atropisomerismo"
Clayden, Jonathan. « Atropisomerism ». Tetrahedron 60, no 20 (mai 2004) : 4335. http://dx.doi.org/10.1016/j.tet.2004.03.002.
Texte intégralCzarnocki, Zbigniew, et Piotr Pomarański. « Arylpyridines : A Review from Selective Synthesis to Atropisomerism ». Synthesis 51, no 03 (14 décembre 2018) : 587–611. http://dx.doi.org/10.1055/s-0037-1611365.
Texte intégralSiegel, Jay. « Prologue : Atropisomerism ». Synlett 29, no 16 (21 septembre 2018) : 2122–25. http://dx.doi.org/10.1055/s-0037-1610908.
Texte intégralFordyce, Euan A. F., S. Fraser Hunt, Damien Crepin, Stuart T. Onions, Guillaume F. Parra, Chris J. Sleigh, John King-Underwood, Harry Finch et John Murray. « Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors : their synthesis, structural analysis and biological activities ». MedChemComm 9, no 3 (2018) : 583–89. http://dx.doi.org/10.1039/c8md00033f.
Texte intégralBirepinte, Mélodie, Frédéric Robert, Sandra Pinet, Laurent Chabaud et Mathieu Pucheault. « Non-biaryl atropisomerism at the C–B bond in sterically hindered aminoarylboranes ». Organic & ; Biomolecular Chemistry 18, no 16 (2020) : 3007–11. http://dx.doi.org/10.1039/d0ob00421a.
Texte intégralBischetti, Martina, Giuseppe Pomarico, Sara Nardis, Federica Mandoj, Daniel O. Cicero et Roberto Paolesse. « 5,10,15-Triarylcorrole atropisomerism ». Journal of Porphyrins and Phthalocyanines 24, no 01n03 (janvier 2020) : 153–60. http://dx.doi.org/10.1142/s1088424619500706.
Texte intégralSiegel, Jay. « Cluster Preface : Atropisomerism ». Synlett 29, no 16 (21 septembre 2018) : 2120–21. http://dx.doi.org/10.1055/s-0037-1610998.
Texte intégralBoiadjiev, Stefan E., et David A. Lightner. « Atropisomerism in monopyrroles ». Tetrahedron : Asymmetry 13, no 16 (août 2002) : 1721–32. http://dx.doi.org/10.1016/s0957-4166(02)00481-0.
Texte intégralCiogli, A., S. Vivek Kumar, M. Mancinelli, A. Mazzanti, S. Perumal, C. Severi et C. Villani. « Atropisomerism in 3-arylthiazolidine-2-thiones. A combined dynamic NMR and dynamic HPLC study ». Organic & ; Biomolecular Chemistry 14, no 47 (2016) : 11137–47. http://dx.doi.org/10.1039/c6ob02145j.
Texte intégralKöster, Roland, Günther Seidel, Susanna Kerschl et Bernd Wrackmeyer. « Atropisomerism in Boron-Nitrogen Heterocycles/Atropisomerism in Boron-Nitrogen Heterocycles ». Zeitschrift für Naturforschung B 42, no 2 (1 février 1987) : 191–94. http://dx.doi.org/10.1515/znb-1987-0212.
Texte intégralThèses sur le sujet "Atropisomerismo"
Fontanive, Luca. « Nanoscale intercation for higher efficiency of contrast media ». Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4476.
Texte intégralIopamidolo, Iomeprolo e Iopromide sono Mezzi di Contrasto Iodinati Non-ionici (MCIN) usati in urografia e angiografia come soluzioni concentrate. I dati relativi ai MCIN presenti in letteratura mostrano un’abbondanza di informazioni cliniche ma una carenza di dati riguardanti le loro caratteristiche chimico-fisiche. L’efficenza di questi composti in ambito medico è dovuta alla combinazione di tali proprietà. Risulta quindi necessario uno studio relativo ai dettagli molecolari per chiarire i contributi di ogni gruppo funzionale del sistema che determinano le differenze in termini di comportamento chimico-fisico. Le soluzioni concentrate di MCIN sono caratterizzate da bassi valori di viscosità e osmolalità dovuti all’autoassemblamento del sistema che genera aggregati nanostrutturati solubili in soluzione acquosa. Da queste considerazioni, questo lavoro di ricerca si è focalizzata su tecniche spettroscopiche, termodinamiche e di simulazioni di dinamica molecolare per indagare il fenomeno dell’associazione, sia in funzione della temperatura che della concentrazione, relazionato alle interazioni intermolecolari che spesso sono la principale causa della stabilità delle soluzioni concentrate di MCIN. Questi composti possiedono una struttura molecolare relativamente semplice, ma sono sistemi complessi in quanto soggetti all’atropisomerismo che causa la coesistenza di isomeri strutturali (atropisomeri) in soluzione, quindi di diverse geometrie di interazione soluto-soluto. Il primo approccio sperimentale è stata la caratterizazione molecolare attraverso la spettroscopia NMR per determinare gli equilibri conformazionali in termini di percentuali di popolazione in soluzione. Studi termodinamici hanno permesso di classificare Iopamidolo, Iomeprolo e Iopromide in base alle loro caratteristiche idrofiliche ed idrofobiche nei confronti delle molecole di acqua. Parallelamente sono state realizzate simulazioni di dinamica molecolare per ottenere informazioni riguardo la sfera di idratazione (confrontate con i dati termodinamici da letteratura) e sul processo di associazione che è stato studiato in funzione della temperatura sia con la spettroscopia NMR che con quella Brillouin. Ulteriori informazioni sulle interazioni intermolecolari e sull’atropisomerismo sono state ottenute analizzando anche lo stato solido dello Iopamidolo e dello Iomeprolo (sia sui vetri che sui cristalli) tramite tecniche spettroscopiche, calorimetriche e diffrattometriche i cui risultati hanno mostrato analogie in termini di interazioni intermolecolari fra le catene laterali. Inoltre, studi in funzione della temperatura hanno mostrato alcune transizioni solido-solido. L’accumulo di dati sperimentali relativi alla calorimetria isoterma e a scansione, traiettorie di dinamica molecolare ed alle varie spettroscopie, ha permesso di estendere il quadro generale delle conoscenze delle proprietà chimico-fisiche dei MCIN.
Iopamidol, Iomeprol and Iopromide are Non-ionic Iodinated Contrast Media (NICMs) are used as concentrated solutions in x-Ray diagnostics as angiography and urography. The analysis of the current literature knowledge on NICMs shows an clear abundance of clinical diagnosis data but a lack of information on their physico-chemical properties. The success of these molecules in diagnosis is due to a combination of their properties, but a clarification of the role of structural determinants affecting the processes in concentrated solution is necessary. Thus a study of the molecular details may shed light on the differences in physico-chemical behavior. The concentrated solutions of NICMs are characterize by low viscosity and osmolality values due to the self-assembling of the system that generates soluble nano-structured aggregates in aqueous solution. Standing these considerations, the research work focused on spectroscopic, thermodynamics and MD simulation techniques to probe the association phenomenon, as a function of concentration and temperature. The interplay of the intermolecular interactions are the main reason for the stability of the concentrated solution of NICMs. Non-ionic iodinated contrast media have quite a simple molecular structure, but they show a complex behaviour due to the atropisomerism phenomenon. The coexistence of several structural isomers (atropisomers) in solution is at the basis of the different geometries of solute-solute interasctions. Thus, the first study whas been the molecular characterization of these molecules by using NMR spectroscopy to probe the conformational equilibria in terms of conformer population in solution. Thermodynamic approaches provided a classification of Iopamidol, Iomeprol and Iopromide according to their thermodynamics behaviour in terms of hydrophilic and hydrophobic interactions with water molecules. In parallel, MD simulations data were carried out to provide information about hydration shell (which were compared with experimental data from literature) and aggregation process. Similarly, the association was probed by both NMR and experimental thermodynamic data. To have more information on the nature of intermolecular interactions and atropisomerism phenomenon the solids of Iomeprol and Iopamidol (either or glasses and crystals) were analyzed by spectroscopic, calorimetric and diffractometric techniques that shown agreement in terms of intermolecular interactions among side chains. Furthemore, solid-solid transitions were detected as a function of temperature. By collecting experimental data by isothermal and scanning calorimetry, thermodynamic properties, molecular dynamics simulations and expecially by several spectroscopics methods a choerent description of the structure and dynamics of NICMs has been achieved. These results provide new knowledge on thier physico-chemical properties and allow us to interpret some anclear phenomena.
XXIII Ciclo
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Yau, Chi. « Atropisomerism and the synthesis of lignans ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62875.pdf.
Texte intégralSenior, James Daniel. « Atropisomerism in biaryl sulfides and sulfones ». Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498670.
Texte intégralWilson, Paul. « Reducing catalyst loadings in radical cyclisation reactions and investigating atropisomerism in enamides ». Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/34645/.
Texte intégralArmstrong, Roland. « Catalytic asymmetric reactions employing chiral cations ». Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:6f38eb98-32ff-4b06-b144-100480da87dd.
Texte intégralPerticarari, Sofia. « Atropisomeric xanthines : Synthesis, stereodynamics and absolute configuration ». Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9025/.
Texte intégralBirepinte, Mélodie. « Amino(organo)boranes, synthèse et propriétés ». Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0231.
Texte intégralThis manuscript presents the synthesis, reactivity and properties of amino(organo)boranes. The diisopropylaminoborane has been used for the formation of carbon-boron bonds. Its reactivity as a borylating agent was first explored for the hydroboration of alkynes catalyzed by Schwartz reageant. A large variety of alkenylaminoboranes, -boronates and -diazaborolanes was thus synthesized. Their stereoselective transformation into E and Z bromoalkenes was also optimized. The borylation of terminal alkynes via a tandem process of dehydrogenation/ dehydrogenative coupling allowed the access to a large scope of alkynylaminoboranes. Finally, the different reactivities of aminoboranes were used for the preparation of borinic acids bearing a phosphine group but also of a new class of chiral boron derivatives via a C-B atropisomerism. These chiral aminoarylboranes were fully characterized after separating the enantiomers and running spectroscopic analyses and racemization studies
Augros, David. « Synthèses de biaryles atropoenrichis et de biphénylènes via des arynes substitués ». Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF040/document.
Texte intégralThis work consisted in the study of the “aryne coupling”, a transition-metal free process to access biaryl moieties, which involves the reaction between two in situ generated intermediates: a nucleophilic aryllithium derivative and an electrophilic aryne. This work resided in the optimization of the atropoenantioselective version of the aryne coupling and its application to the formal synthesis of (-)-steganacin. We then moved to the atropoenantioselective version of the reaction, by introducing chiral ligands in the reaction mixture, which aim was to coordinate the aryllithium species and to transfer their chiral information to the biaryl axis. After optimization of various reaction parameters, some enantiomeric excesses were obtained as well as various side products in some cases, among which biphenylene derivatives. According to the potential applications of these compounds, another part of this work was dedicated to their synthesis by means of aryne dimerization reactions
Böhnisch, Torben. « C2-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis ». Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-876A-6.
Texte intégralRebouças, Júlio Santos. « Exploring and exploiting Ruthenium-porphyrin complexes : functionalization, atropisomerism, small-molecule recognition, catalysis, and biological implications ». Thesis, 2006. http://hdl.handle.net/2429/18618.
Texte intégralScience, Faculty of
Chemistry, Department of
Graduate
Livres sur le sujet "Atropisomerismo"
Westlund, Neil Edward. Atropisomerism in hindered tertiary amides. Manchester : University of Manchester, 1996.
Trouver le texte intégralLassaletta, José M. Atropisomerism and Axial Chirality. WORLD SCIENTIFIC (EUROPE), 2018. http://dx.doi.org/10.1142/q0192.
Texte intégralChapitres de livres sur le sujet "Atropisomerismo"
Ōki, Michinori. « Recent Advances in Atropisomerism ». Dans Topics in Stereochemistry, 1–81. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470147238.ch1.
Texte intégralCesàro, Attilio, Barbara Bellich, Giovanna Giannini et Alessandro Maiocchi. « Conformational Disorder and Atropisomerism in Pharmaceutical Compounds ». Dans Disordered Pharmaceutical Materials, 161–82. Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527652693.ch6.
Texte intégralDreikorn, Barry A., Glen P. Jourdan et Harold R. Hall. « Influence of Atropisomerism on the Fungicidal Activity of a Series of Thioalkylphenylalanines ». Dans ACS Symposium Series, 575–88. Washington, DC : American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0443.ch046.
Texte intégralJoshi, Gaurav, Manpreet Kaur et Raj Kumar. « Dynamic Axial Chirality in Drug Design and Discovery : Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges ». Dans Drug Discovery and Development, 103–24. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-5534-3_4.
Texte intégralRos, Abel, Pedro Ramírez-López, Rosario Fernández et José María Lassaletta. « Asymmetric Synthesis of Axially Chiral Biaryls and Heterobiaryls ». Dans Atropisomerism and Axial Chirality, 1–97. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0001.
Texte intégralKondoh, Azusa, et Masahiro Terada. « Applications of Axially Chiral Organocatalysts ». Dans Atropisomerism and Axial Chirality, 99–147. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0002.
Texte intégralYurino, Taiga, et Takeshi Ohkuma. « Axially Chiral P,P-Ligands for Asymmetric Metal-Catalyzed Reactions ». Dans Atropisomerism and Axial Chirality, 149–247. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0003.
Texte intégralGualtierotti, Jean-Baptiste, Valentín Hornillos et Ben L. Feringa. « Axially Chiral Monodentate Phosphorus Ligands for Asymmetric Metal-Catalyzed Reactions ». Dans Atropisomerism and Axial Chirality, 249–377. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0004.
Texte intégralRokade, Balaji V., et Patrick J. Guiry. « Axially Chiral P,X-Ligands (X = N, O, and S) for Asymmetric Metal-Catalyzed Reactions ». Dans Atropisomerism and Axial Chirality, 379–445. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0005.
Texte intégralYing, Jun, et Lin Pu. « Axially Chiral X,X-Ligands (X = N, O) for Asymmetric Metal-Catalyzed Reactions ». Dans Atropisomerism and Axial Chirality, 447–88. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346469_0006.
Texte intégralActes de conférences sur le sujet "Atropisomerismo"
Cardoso, Flávio Sêga Pereira, et Aaron Aponick. « A New Approach to Atropisomerism ». Dans 15th Brazilian Meeting on Organic Synthesis. São Paulo : Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013816154041.
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