Littérature scientifique sur le sujet « Art. 55 c. 2 c.p »
Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres
Consultez les listes thématiques d’articles de revues, de livres, de thèses, de rapports de conférences et d’autres sources académiques sur le sujet « Art. 55 c. 2 c.p ».
À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.
Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.
Articles de revues sur le sujet "Art. 55 c. 2 c.p"
1
Ayșe, Atay, Najafova Lamia, Kurtulmus Huseyin Mehmet et Üşümez Aslihan. « The micro-shear bond strength of two different repair systems to indirect restorative materials ». STOMATOLOGY EDU JOURNAL 7, no 4 (2020) : 233–41. http://dx.doi.org/10.25241/stomaeduj.2020.7(4).art.1.
Texte intégralRésumé :
Introduction The aim of this study was to evaluate the micro-shear bond strength (μSBS) of different repair systems (Clearfil Repair, iGOS Repair) to restorative materials for CAD/CAM (Cerasmart, Lava Ultimate, InCoris TZI , VITA Suprinity, VITA Mark II, IPS e.max CAD, IPS Empress CAD). Methodology The 140 1.2 mm-thick specimens were prepared from CAD/CAM blocks (n=20) and thermocycled (10,000 cycles, 5–55°C, dwell time 20s). The specimens were randomly divided into two groups according to the repair system: Clearfil Repair (40% phosphoric acid+mixture of Clearfil Porcelain Bond Activator and Clearfil SE Bond Primer+Clearfil SE Bond+CLEARFIL MAJESTY ES-2) and iGOS Repair (40% phosphoric acid+ Multi Primer LIQUID+ iGOS Bond+ iGOS Universal). The composite resins were polymerized. All specimens were stored in distilled water at 37°C for 24 hours. The μSBS test was performed with a micro-shear testing machine (at 1 mm/min). The data were analyzed using two-way ANOVA, Tukey’s multiple comparison tests at a significance level of p<0.05. Each failure modes were examined under a stereomicroscope at×16 magnification. Results The type of CAD/CAM restorative material and repair system showed a significant effect on the μSBS (p<0.05). Specimens repaired with the iGOS Repair system showed the highest μSBS values than the Clearfil Repair system among all tested materials except for the InCoris TZI group (p<0.05). Conclusion All groups, except for the InCoris TZI group, repaired with iGOS Repair system showed higher μSBS than Clearfil Repair. The type of restoration and repair material is important in the success of the fracture repair.
2
Faderl, Stefan, Meir Wetzler, David Rizzieri, Gary Schiller, Madan Jagasia, Robert Stuart, Siddhartha Ganguly et al. « Clofarabine Plus Cytarabine Compared With Cytarabine Alone in Older Patients With Relapsed or Refractory Acute Myelogenous Leukemia : Results From the CLASSIC I Trial ». Journal of Clinical Oncology 30, no 20 (10 juillet 2012) : 2492–99. http://dx.doi.org/10.1200/jco.2011.37.9743.
Texte intégralRésumé :
Purpose To compare the receipt of clofarabine plus cytarabine (Clo+Ara-C arm) with cytarabine (Ara-C arm) in patients ≥ 55 years old with refractory or relapsed acute myelogenous leukemia (AML). Patients and Methods Patients were randomly assigned to receive either clofarabine (Clo) 40 mg/m2 or a placebo followed by Ara-C 1 g/m2 for five consecutive days. The primary end point was overall survival (OS). Secondary end points included event-free survival (EFS), 4-month EFS, overall remission rate (ORR; complete remission [CR] plus CR with incomplete peripheral blood count recovery), disease-free survival (DFS), duration of remission (DOR), and safety. Results Among 320 patients with confirmed AML (median age, 67 years), the median OS was 6.6 months in the Clo+Ara-C arm and 6.3 months in the Ara-C arm (hazard ratio [HR], 1.00; 95% CI, 0.78 to 1.28; P = 1.00). The ORR was 46.9% in the Clo+Ara-C arm (35.2% CR) versus 22.9% in the Ara-C arm (17.8% CR; P < .01). EFS (HR: 0.63; 95% CI, 0.49 to 0.80; P < .01) and 4-month EFS (37.7% v 16.6%; P < .01) favored the Clo+Ara-C arm compared with Ara-C arm, respectively. DFS and DOR were similar in both arms. Overall 30-day mortality was 16% and 5% for CLO+Ara-C and Ara-C arms, respectively. In the Clo+Ara-C and Ara-C arms, the most common grade 3 to 4 toxicities were febrile neutropenia (47% v 35%, respectively), hypokalemia (18% v 11%, respectively), thrombocytopenia (16% v 17%, respectively), pneumonia (14% v 10%, respectively), anemia (13% v 0%, respectively), neutropenia (11% v 9%, respectively), increased AST (11% v 2%, respectively), and increased ALT (10% v 3%, respectively). Conclusion Although the primary end point of OS did not differ between arms, Clo+Ara-C significantly improved response rates and EFS. Study follow-up continues, and the role of clofarabine in the treatment of adult patients with AML continues to be investigated.
3
Mancuso, Maria E., Elena Santagostino, Maria G. Rumi, Silvia Linari, Antonio Coppola, Angiola Rocino, Alfonso Iorio et al. « High Efficacy of Combination Therapy with Pegylated Interferon and Ribavirin in Hemophiliacs with Chronic Hepatitis C. » Blood 106, no 11 (16 novembre 2005) : 3219. http://dx.doi.org/10.1182/blood.v106.11.3219.3219.
Texte intégralRésumé :
Abstract Pegylated interferon (Peg-IFN) plus ribavirin is the standard treatment for patients with chronic hepatitis C. In a multicenter open trial, we assessed the efficacy and tolerability of this treatment in 78 HIV negative hemophiliacs (age: 20–64 years) with persistently high transaminase values. Sixty-four were naïve and 14 were relapsers to IFN monotherapy. Cirrhosis was clinically detected in 12 patients (15%). HCV genotype was 1 in 69%, 2a/c in 14%, 3a in 14% and 4 in 3%. Peg-IFN alpha-2b was given subcutaneously at doses of 1.5 mcg/Kg/week for 48 weeks in genotypes 1 and 4 and for 24 weeks in genotypes 2 and 3; oral ribavirin at 800–1200 mg/day based on body weight. Treatment was stopped in patients with polymerase chain reaction positive HCV-RNA at month 6. Results: 11 patients (14%) withdrew for side effects (4) or non-compliance (7). Neutropenia (<500 cells/mmc), decompensated diabetes, ALT flares, and vomiting not responding to antiemetic drugs were reasons for treatment discontinuation. The median fall in hemoglobin levels was 3.1 g/dL. Weight loss (38%), fatigue (33%) and cephalalgia (15%) were frequent side effects. Thirty-two patients (41%) required dose reduction of ribavirin (23, 29%) or Peg-IFN (20, 26%). At the end of the 6-month follow-up, sustained virological response (SVR) was achieved in 43 patients (55%): 40/64 naïve (63%) and 3/14 relapsers (21%, p = 0.007). Five patients (6%), all relapsers to IFN monotherapy, had a virological breakthrough during treatment and 4 (5%) relapsed during the post-treatment follow-up period. SVR was obtained in 86% genotypes 2/3 and 43% genotypes 1/4 (p = 0.001). Predictors of SVR were evaluated by univariate analysis in the 64 naïve patients. SVR was significantly associated with HCV infection type 2 and 3 (86% vs 50% in HCV type 1 and 4; p = 0.008), absence of cirrhosis (97.5% vs 75% in non-responders; p = 0.02) and higher pre-treatment serum ALT levels (111 vs 75 IU/L in non-responders; p = 0.02). SVR rates did not differ in relation to patient’s age, pretreatment HCV viremia, median disease duration and compliance to full-dose treatment. Conclusions: combination therapy with Peg-IFN plus ribavirin is the recommended therapeutic option for hemophiliacs with hepatitis C chronic infection. Relapsers to IFN monotherapy may benefit of re-treatment with Peg-IFN plus ribavirin achieving at least 20% SVR. Genotype 2 and 3 infection is the most significant predictor of SVR.
4
Lapshina, Z. S. « ARCHEOLOGY OF THE LOWER AMUR RIVER : TO THE STUDY OF THE SUKPAI ARTISTIC STYLE AMONG THE PETROGLYPHS OF THE AMUR AND USSURI ». History : facts and symbols, no 2 (9 juin 2022) : 46–55. http://dx.doi.org/10.24888/2410-4205-2022-31-2-47-55.
Texte intégralRésumé :
Among the hundreds of archaeological sites in the lower reaches of the Amur basin, a special place belongs to the stones and rocks with ancient drawings. The rock art of the Lower Amur region has been studied since the sixties of the nineteenth century. Among the discoverers and researchers are the names of local historians and scientists. Systematic academic scientific research of petroglyphs monuments was carried out only 100 years later, in the sixties of the twentieth century, by Soviet archaeologists. The research source base (topography, description, tracing, scientific interpretation and publication of materials) was prepared by a team of employees of the Far Eastern Archaeological Expedition of the Institute of Archeology and Ethnography of the Siberian Branch of the USSR Academy of Sciences under the leadership of A. P. Okladnikov. Pisanitsa on the Sukpai River in the Ussuri River basin is one of the new sites of rock art in the region, it was discovered in the 1980s by archaeologist V. I. Dyakov, an employee of the Institute of History, Archeology and Ethnography of the Peoples of the Far East of the Far Eastern Branch of the Russian Academy of Sciences. The article offers the experience of studying the stylistic diversity of the Lower Amur rock art monuments, namely, the drawings of the Sukpai petroglyph, which predetermines its relevance. The novelty of the study is due to the fact that the article highlights the signs of the Sukpai artistic style, the extent of its distribution among the petroglyphs of the region and adjacent territories. To write the work, a wide range of research methods was used, including the method of analyzing scientific literature, the sources were scientific papers on the topic of the study. The result of the research: a) the distinctive features of the style of plots on the rock of the Sukpai River are highlighted; b) similar images were traced on the stones and rocks of the Sikachi-Alyan-Malyshevo site; c) substantiation of the identification of the Sukpai artistic style among the petroglyphs of the Lower Amur; d) the similarity of the drawings of the sukpai style with the plots of the shamanic thematic direction of the rock art monuments of the adjacent territories of Eastern Siberia, Yakutia, the Upper and Middle Amur Region, and Transbaikalia was traced.
5
Xu, Chuanhui, Anke Van Den Berg, Arjan Diepstra, Miao Wang, Debora Jong, Hans JTWM Vos, Peter Moller, Sibrand Poppema et Lydia Visser. « The HGF/c-Met Signaling Pathway in Hodgkin Lymphoma. » Blood 114, no 22 (20 novembre 2009) : 1551. http://dx.doi.org/10.1182/blood.v114.22.1551.1551.
Texte intégralRésumé :
Abstract Abstract 1551 Poster Board I-574 Introduction Hodgkin lymphoma (HL) is a B-cell neoplasm characterized by a minority of neoplastic cells, the so-called Hodgkin and Reed-Sternberg (HRS) cells, which are located within an extensive infiltrate of reactive cells. Aberrant signaling of various receptor tyrosine kinases (RTKs) via autocrine or paracrine mechanisms contributes to the survival and proliferation of HRS cells. Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway has been implicated in the pathophysiology of many cancers, but its role in HL is poorly investigated. In this study, we investigated the expression of c-Met and HGF in HL patient tissues and studied the cell physiological effects of the HGF/c-Met signaling pathway using a c-Met tyrosine kinase inhibitor SU11274 in HL cell lines. Methods The expression of c-Met and HGF in HL patient tissues was studied by immunohistochemistry on a HL tissue microarray. The c-Met expression level was determined by Western blotting, while HGF mRNA and protein levels were measured by quantitative (q)RT-PCR and ELISA in four HL cell lines, i.e. L428, KMH2, L1236 and U-HO1. The effects of SU11274 treatment on the activity of the HGF/c-Met signaling pathway was determined by detection of phosphorylated downstream targets by Western blotting. Effects on cell growth and cell cycle were determined by 3-(4,5- Dimethylthiazol -2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay and by flow cytometry with Propidium iodide (PI), respectively. Results C-Met was detected in HRS cells in 55% (26/47) of HL patient tissues. Expression of HGF was detected in HRS cells in 5 c-Met positive and 2 c-Met negative HL patient tissues. C-Met was highly expressed in L428 compared to three other HL cell lines, whereas HGF was highly expressed in KMH2 and not or only weakly in the other three HL cell lines. Detectable levels of phosphorylated c-Met (p-Met) were observed only in L428 consistent with the high basal expression level of c-Met. Phosphorylation of c-Met, Akt and Erk1/2 were upregulated upon HGF stimulation of L428 cells. This activation could be blocked by inhibiting c-Met activation with SU11274. In functional studies, SU11274 suppressed cell growth in L428, promoted G2/M cell cycle arrest after 24h incubation, and induced tetraploidy after 48h. Washing of the cells after induction of G2/M arrest resulted in normal cell cycle progression indicating that the G2/M cell cycle arrest was reversible. Inhibition of PI3K, MEK1/2 and Erk1/2, three downstream targets of the HGF/c-Met signaling pathway, also induced G2/M cell cycle arrest in L428, indicating that these factors are involved in the G2/M cell cycle arrest induced by SU11274. Conclusion Co-expression of c-Met and HGF in HRS cells was observed in 11% of the HL patient tissues and HGF/c-Met signaling pathway regulates cell growth and cell cycle progression in L428 cells. Disclosures No relevant conflicts of interest to declare.
6
Porojan, Liliana, Roxana-Diana Vasiliu, Sorin-Daniel Porojan et Mihaela-Ionela Bîrdeanu. « Surface Quality Evaluation of Removable Thermoplastic Dental Appliances Related to Staining Beverages and Cleaning Agents ». Polymers 12, no 8 (3 août 2020) : 1736. http://dx.doi.org/10.3390/polym12081736.
Texte intégralRésumé :
(1) Background: Thermoplastic materials are not inert and subject to changes in the oral environment, which affect their surface quality. Color stability and topographic characteristics of clear thermoplastic appliances are critical considerations. The study aimed to evaluate the optical changes and surface topography of different thermoplastic materials related to staining beverages and cleaning agents. (2) Methods: Thermoplastic polyethylene terephthalate glycol (PET-G) material specimens were selected for the study: S (Duran, Scheu-Dental GmbH, Iserlohn, Germany), D (Biolon, Dreve Dentamid GmbH, Unna, Germany), and B (Crystal, Bio Art Dental Equipment, Sao Carlos, Brazil). Four different media were involved for immersion: coffee (C) and black tea (T) at 55 °C, Coca-Cola (K) at 5 °C, and distilled water (W) at 22 °C. As for cleaning, chemical options and mechanical brushing were selected (P-powder, T-tablets, and X-brushing). Color changes, and mean surface roughness were measured at 24 h, 48 h, and after 7 days. Statistical analysis was performed. After the testing period, atomic force microscopy (AFM) analyses and SEM images were registered in order to characterize the surface topography. (3) Results: Quantitative color change evaluations revealed a slight change in color after 24 h and an extremely marked change after 48 h, respective 7 days. Mean roughness values are kept below the clinically acceptable limit of 0.20 µm for all samples. Related to mean nanoroughness values Sa, and 3D evaluations of the surface quality, Biolon samples have demonstrated the most constant behavior, while Crystal samples are visibly influenced by water immersion. Related to the cleaning method, the topography of Duran samples was influenced by mechanical brushing. (4) Conclusions: Nanoscale investigations provided high accuracy and more realistic surface quality examinations of the examined samples compared to profilometry. Both SEM and AFM should be used for a more detailed description of the surface topography.
7
Lemoine, Sandrine, Gallic Beauchef, Lan Zhu, Emmanuelle Renard, Olivier Lepage, Massimo Massetti, André Khayat, Philippe Galera, Jean-Louis Gérard et Jean-Luc Hanouz. « Signaling Pathways Involved in Desflurane-induced Postconditioning in Human Atrial Myocardium In Vitro ». Anesthesiology 109, no 6 (1 décembre 2008) : 1036–44. http://dx.doi.org/10.1097/aln.0b013e31818d6b09.
Texte intégralRésumé :
Background Isoflurane and sevoflurane have been shown to elicit myocardial postconditioning, but the effect of desflurane remain unknown. The authors studied the mechanisms involved in desflurane-induced myocardial postconditioning. Methods Contracting isolated human right atrial trabeculae (34 degrees C, stimulation frequency 1 Hz) were exposed to 30-min hypoxia followed by 60-min reoxygenation. Desflurane at 3%, 6%, and 9% was administered during the first 5-min of reoxygenation. Postconditioning with 6% desflurane was studied in the presence of 1 microM calphostin C, a protein kinase C inhibitor; 800 mm 5-hydroxydecanoate, a mitochondrial adenosine triphosphate-sensitive potassium channels antagonist; 1 microM Akt inhibitor; 20 microM PD89058, an extracellular-regulated kinase 1/2 inhibitor; and 1 microM SB 202190, a p38 mitogen-activated protein kinase inhibitor. The force of contraction at the end of the 60-min reoxygenation period was compared (mean +/- SD). The p38 mitogen-activated protein kinase phosphorylation was studied using Western blotting. Results Desflurane at 3% (77 +/- 10% of baseline), 6% (90 +/- 14% of baseline), and 9% (86 +/- 11% of baseline) enhanced the recovery of force after 60 min of reoxygenation as compared with the control group (51 +/- 9% of baseline; P < 0.001). Calphostin C (55 +/- 3% of baseline), 5-hydroxydecanoate (53 +/- 3% of baseline), Akt inhibitor (57 +/- 8% of baseline), PD89058 (64 +/- 6% of baseline), and SB 202190 (61 +/- 3% of baseline) abolished desflurane-induced postconditioning. Western blot analysis showed that 6% desflurane increased p38 mitogen-activated protein kinase phosphorylation. Conclusions In vitro, desflurane postconditioned human atrial myocardium through protein kinase C activation, opening of mitochondrial adenosine triphosphate-sensitive potassium channels, Akt and extracellular-regulated kinase 1/2 activation, and p38 mitogen-activated protein kinase phosphorylation.
8
Heist, Rebecca Suk, Monica Motwani, Fabrice Barlesi, Jonathan Wade Goldman, Karen Kelly, Yan Sun, Jun Wu, Bruce Allen Bach et D. Ross Camidge. « c-Met expression and response to telisotuzumab vedotin (teliso-v) in patients with non-small cell lung cancer. » Journal of Clinical Oncology 37, no 15_suppl (20 mai 2019) : 9023. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9023.
Texte intégralRésumé :
9023 Background: c-Met overexpression (OE) and MET amplification (amp) are prognostic of poor outcome for non-small cell lung cancer (NSCLC). Telisotuzumab vedotin (ABBV-399; teliso-v [T]), an anti–c-Met Ab and monomethyl auristatin E drug conjugate, showed efficacy as monotherapy (mono) and combined with erlotinib (T+Er) in a phase 1/1b trial (NCT02099058) in NSCLC patients (pts) with c-Met OE. Here, c-Met OE (by immunohistochemistry [IHC]) and its association with T efficacy were explored. IHC, mRNA, and amp platforms for MET were also compared. Methods: Archival tissue from pts with NSCLC in the phase 1/1b trial was examined. c-Met was assessed centrally by IHC with SP44 Ab (Ventana Medical Systems) and pts with c-Met OE (membrane H-score [H-S] of ≥150) were enrolled. MET mRNA expression was analyzed from total RNA and sequenced on HiSeq 3000 (Illumina). MET amp was analyzed by FISH ( MET/ CEP7 ratio of ≥2) or whole-exome sequencing (copy number ≥2). Efficacy in the T mono every 2 (TQ2W) or 3 (TQ3W) weeks and the T+Er EGFR mutant cohorts was assessed for IHC H-S ≥150 and ≥225. Results: As of Dec 2018, 238 pts with NSCLC were screened centrally for c-Met OE. Of these, 118 pts were enrolled. For screened pts, 76%/37% of nonsquamous (NSQ, n = 201) and 58%/16% of squamous (SQ, n = 32) pts had H-S ≥150/≥225; 75%/41% of NSQ and 55%/16% of SQ NSCLC pts had ≥50% cells with 2+/3+ staining intensity. MET amp was reported for 5 pts, all with high H-S (≥270); there was an association between MET amp and MET RNA levels (n = 4) (t-test p value: 0.0002). See Table for ORR and median PFS by H-S and T treatment. Conclusions: c-Met expression prevalence in NSCLC showed a similar trend as in previous reports. In T+Er-treated pts, ORR was higher for those with c-Met H-S ≥225 than ≥150– < 225, suggesting that biomarker expression may act as an effect size multiplier. Optimization of the c-Met IHC cutoff warrants further investigation. Clinical trial information: NCT02099058. [Table: see text]
9
Nelson, Matthew J., M. Brennan Harris, Marvin O. Boluyt, Hyun Seok Hwang et Joseph W. Starnes. « Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no 4 (avril 2011) : R993—R1000. http://dx.doi.org/10.1152/ajpregu.00405.2010.
Texte intégralRésumé :
The purpose of this study was to test the hypothesis that exercise-induced cardiac adaptations would be attenuated by the free radical scavenger N-2-mercaptopropionyl glycine (MPG). Male Sprague-Dawley rats were divided into four groups ( n = 9–13 per group) for 3–4 wk: sedentary (S), S+MPG (100 mg/kg ip daily), exercised on a treadmill (E) (60 min/day, 5 days/wk, at a speed of 20 m/min up a 6° grade in a 6°C room), or E+MPG given 10 min prior to exercise. Additional rats ( n = 55) were used to determine acute exercise effects on myocardial redox state [nonprotein nonglutathione sulfhydryls (NPNGSH)] and PI3K/Akt signaling pathway activation. Compared with S, NPNGSH levels were 48% lower in E ( P < 0.05) and unchanged in E+MPG ( P > 0.05). MPG also attenuated exercise-induced activation of the signaling proteins Akt and S6. Hearts from the 4-wk groups were weighed, and cardiac function was evaluated using an isolated perfused working heart preparation. Similar increases ( P < 0.05) in both exercised groups were observed for heart weight and heart weight-to-body weight ratio. Cardiac function improved in E vs. S, as indicated by greater ( P < 0.05) external work performed (cardiac output × systolic pressure) and efficiency of external work (work/V̇o2). MPG prevented these exercise-induced functional improvements. Skeletal muscle mitochondria content increased to similar levels in E and E+MPG. This study provides evidence that free radicals do not play an essential role in the development of exercise-induced cardiac hypertrophy; however, they appear to be involved in functional cardiac adaptations, which may be mediated through the PI3K/Akt pathway.
10
Choi, Jungmin, Aranzazu Manzano, Weilai Dong, Stefania Bellone, Elena Bonazzoli, Luca Zammataro, Xiaotong Yao et al. « Integrated mutational landscape analysis of uterine leiomyosarcomas ». Proceedings of the National Academy of Sciences 118, no 15 (5 avril 2021) : e2025182118. http://dx.doi.org/10.1073/pnas.2025182118.
Texte intégralRésumé :
Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 from The Cancer Genome Atlas (TCGA). Among them, a total of 55 Yale samples including two patient-derived xenografts (PDXs) and 27 TCGA samples have whole-exome sequencing (WES) data; 10 Yale and 27 TCGA samples have RNA-sequencing (RNA-Seq) data; and 11 Yale and 10 TCGA samples have whole-genome sequencing (WGS) data. We found recurrent somatic mutations in TP53, MED12, and PTEN genes. Top somatic mutated genes included TP53, ATRX, PTEN, and MEN1 genes. Somatic copy number variation (CNV) analysis identified 8 copy-number gains, including 5p15.33 (TERT), 8q24.21 (C-MYC), and 17p11.2 (MYOCD, MAP2K4) amplifications and 29 copy-number losses. Fusions involving tumor suppressors or oncogenes were deetected, with most fusions disrupting RB1, TP53, and ATRX/DAXX, and one fusion (ACTG2-ALK) being potentially targetable. WGS results demonstrated that 76% (16 of 21) of the samples harbored chromoplexy and/or chromothripsis. Clinically actionable mutational signatures of homologous-recombination DNA-repair deficiency (HRD) and microsatellite instability (MSI) were identified in 25% (12 of 48) and 2% (1 of 48) of fresh frozen uLMS, respectively. Finally, we found olaparib (PARPi; P = 0.002), GS-626510 (C-MYC/BETi; P < 0.000001 and P = 0.0005), and copanlisib (PIK3CAi; P = 0.0001) monotherapy to significantly inhibit uLMS-PDXs harboring derangements in C-MYC and PTEN/PIK3CA/AKT genes (LEY11) and/or HRD signatures (LEY16) compared to vehicle-treated mice. These findings define the genetic landscape of uLMS and suggest that a subset of uLMS may benefit from existing PARP-, PIK3CA-, and C-MYC/BET-targeted drugs.
Thèses sur le sujet "Art. 55 c. 2 c.p"
1
ROSSI, LUCREZIA SILVANA. « LA LEGITTIMA DIFESA NEL DOMICILIO (ART. 52 C. 2-4 C.P.) UN¿INDAGINE TRA STORIA, COMPARAZIONE, TEORIA E PRASSI ». Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/852006.
Texte intégralRésumé :
L’elaborato tratta il delicato tema della legittima difesa esercitata nel domicilio, che è stato oggetto di due riforme negli ultimi quindici anni – prima nel 2006, poi nel 2019 –, suscitando diffuse critiche e contrastanti pareri in ordine alla sua esatta portata.
La grande attenzione pubblica per l’istituto e i due interventi legislativi hanno stimolato l’interesse e il desiderio di approfondire l’origine, la ratio e l’evoluzione della scriminante di cui all’art. 52 c.p. Lo scopo della presente indagine è duplice: da una parte, si è cercato di comprendere le esigenze sottostanti alle riforme e, più in generale, il fondamento del bisogno così ben radicato nella società contemporanea di una differenziazione di trattamento per le aggressioni perpetrate all’interno dell’abitazione; dall’altra, invece, partendo dallo studio della disciplina attualmente in vigore e dell’applicazione concreta della medesima ad opera della giurisprudenza, si è provato a trovare un equilibrio più soddisfacente tra le esigenze diffuse e il rispetto della Carta costituzionale e della Convenzione europea dei diritti dell’uomo, in sintesi una “contro-riforma sostenibile”.
La tesi si articola in tre parti, di cui la prima è dedicata all’analisi storico-comparatistica della causa di giustificazione. In particolare, lo studio ripercorre le origini dell’istituto a partire dal diritto romano sino ai giorni nostri, cercando di evidenziare i precedenti storici atti a spiegare l’attuale predisposizione di una figura speciale di legittima difesa a beneficio di colui che sia aggredito in luoghi privati in ordine ai quali vanti uno ius excludendi alios nei confronti dell’aggressore. La ricerca storica è affiancata da un’indagine comparatistica, anch’essa impostata in prospettiva storica, che allarga lo sguardo alle scelte compiute in argomento dai principali ordinamenti europei – segnatamente quello francese e inglese –, nonché dal sistema federale statunitense.
La seconda parte della tesi ha ad oggetto il diritto interno vigente; in particolare l’elaborato affronta prima la legge n. 59 del 13 febbraio 2006 e poi la legge n. 36 del 26 aprile 2019, ossia le riforme che hanno conferito rilievo alla figura speciale della legittima difesa domiciliare. A tal fine, si considera tanto il contesto politico criminale che ne ha segnato l’origine, quanto il contenuto delle riforme alla luce della giurisprudenza di legittimità; è stato infatti svolto uno studio su tutte le pronunce emesse dalla Corte di Cassazione in materia di legittima difesa domiciliare dal 1° gennaio 2000 sino al 1° gennaio 2021. Grazie a tale ricerca è emerso da una parte come la prima riforma risulti sostanzialmente priva di ricadute concrete e, dall’altra, come il secondo intervento legislativo, ove non sottoposto a un’interpretazione correttiva alla luce delle direttrici costituzionali e convenzionali europee, sia pericoloso per la tenuta del sistema. Lungo tale direttrice, l’indagine si sofferma in particolare sul ruolo che dovrebbero assumere il requisito della necessità e le presunzioni normative di legittimità della reazione. Con riferimento al caso dell’eccesso, poi, si prospettano i criteri rilevatori del grave turbamento e delle condizioni di minorata difesa a cui si ricollegano effetti scusanti.
La terza ed ultima parte dell’elaborato, infine, tratta l’istituto in una prospettiva de iure condendo; nello specifico, prendendo le mosse dai risultati raggiunti attraverso l’indagine realizzata, si è provato ad avanzare una proposta di risistemazione della causa di giustificazione che si articola in tre passaggi, idealmente collegati tra loro. Secondo tale ipotesi di lavoro, l’art. 52 c.p. guadagnerebbe in razionalità ed efficacia se, anzitutto, fossero eliminati i commi disciplinanti la legittima difesa domiciliare attualmente in vigore; inoltre, alla disposizione di cui al c. 1 dell’art. 52 c.p. dovrebbe affiancarsi una scusante legata allo stato di turbamento emotivo vissuto dall’aggredito, applicabile alla fattispecie generale per i casi di eccesso e di errore sulla legittima difesa; infine, si potrebbe prevedere una presunzione iuris tantum di pericolo attuale per la sola incolumità dei presenti in caso di aggressione perpetrata all’interno del domicilio e dell’esercizio commerciale.
La compresenza di tali proposte modificative sembrerebbe in grado di conferire un rinnovato equilibrio alla causa di giustificazione, da una parte dando voce e riconoscimento alle istanze diffuse, dall’altra rispettando i principi e i valori di cui la Costituzione e la Convezione europea dei diritti dell’uomo sono espressione, dall’altra ancora imprimendo una spinta contraria rispetto all’attuale tendenza antistatalista, se non addirittura anticostituzionale, di cui le due recenti riforme in materia si sono rese portavoce.The thesis deals with the delicate issue of self defence exercised in the home, which has been the subject of two reforms in the last fifteen years – first in 2006, then in 2019 –, arousing widespread criticism and conflicting opinions regarding its exact scope. The great public attention for the institute and the two legislative interventions have stimulated the interest and the desire to investigate the origin, the ratio and the evolution of the justification regulated by art. 52 c.p. The purpose of this survey is twofold: on the one hand, an attempt has been made to understand the needs underlying the reforms and, more generally, the foundation of the need so well rooted in contemporary society for a differentiation of treatment for attacks perpetrated inside the house; on the other hand, starting from the study of the discipline currently in force and the concrete application of the same by jurisprudence, an attempt has been made to find a more satisfactory balance between the widespread needs and compliance with the Constitutional Charter and the European Convention of human rights, in short a "sustainable counter-reform". The thesis is divided into three parts, of which the first is dedicated to the historical-comparative analysis of the justification. In particular, the study traces the origins of the institute starting from Roman law up to the present day, trying to highlight the historical precedents capable of explaining the current predisposition of a special figure of self defence in favour of anyone who is attacked in private places, where individuals boasts an ius excludendi alios against the aggressor. The historical research is accompanied by a comparative survey, also set in a historical perspective, which broadens the gaze to the choices made on the subject by the main European systems – notably the French and English ones –, as well as by the US federal system. The second part of the thesis concerns the internal law in force; in particular, the paper first deals with law no. 59 of 13 February 2006 and then the law n. 36 of 26 April 2019, i.e. the reforms that have given prominence to the special figure of home self defence. To this end, both the criminal political context that marked its origin and the content of the reforms in the light of the jurisprudence of legitimacy are considered; in fact, a study was carried out on all the rulings issued by the Court of Cassation regarding home self defence from 1 January 2000 until 1 January 2021. Thanks to this research, it emerged on the one hand how the first reform is substantially devoid of concrete repercussions and, on the other hand, how the second legislative intervention, if not subjected to a corrective interpretation in the light of constitutional and conventional guidelines, is dangerous for system tightness. Along this line, the investigation focuses in particular on the role that the requirement of necessity and the normative presumptions of legitimacy of the reaction should assume. With reference to the case of excess, then, are presented the criteria for detecting the serious disturbance and the conditions of impaired defence to which excuse effects are linked. Finally, the third and last part of the paper deals with the institution from a de iure condendo perspective; specifically, starting from the results achieved through the survey carried out, an attempt was made to put forward a proposal for reorganization of the justification which is divided into three steps, ideally connected to each other. According to this working hypothesis, art. 52 c.p. would gain rationality and effectiveness if, first of all, the paragraphs governing home self defence currently in force were eliminated; furthermore, beside the provision referred to art. 52 c. 1 c.p., there should be an excuse linked to the state of emotional disturbance experienced by the attacked, applicable in cases of excess and error in self defence; finally, an iuris tantum presumption of current danger could be envisaged for the sole safety of those present in the event of aggression perpetrated within the home and business. The coexistence of these amending proposals would seem capable of giving a renewed balance to the justification, first of all giving voice and recognition to the widespread requests, furthermore respecting the principles and values of which the Constitution and the European Convention of human rights are an expression, and lastly still giving a push contrary to the current anti-statist tendency, if not even anti-constitutional, of which the two recent reforms on the subject have become spokesmen.
Chapitres de livres sur le sujet "Art. 55 c. 2 c.p"
1
Taber, Douglass F. « Organocatalyzed C–C Ring Construction : The Bradshaw/Bonjoch Synthesis of (−)-Cermizine B ». Dans Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0071.
Texte intégralRésumé :
In a continuation of his studies (OHL20141229, OHL20140811) of organocatalyzed 2+2 photocycloaddition, Thorsten Bach of the Technische Universität München assembled (Angew. Chem. Int. Ed. 2014, 53, 7661) 3 by adding 2 to 1. Li-Xin Wang of the Chengdu Institute of Organic Chemistry also used (Org. Lett. 2014, 16, 6436) an organocatalyst to effect the addition of 5 to 4 to give 6. Shuichi Nakamura of the Nagoya Institute of Technology devised (Org. Lett. 2014, 16, 4452) an organocatalyst that mediated the enantioselective opening of the aziridine 7 to 8. Zhi Li of the National University of Singapore cloned (Chem. Commun. 2014, 50, 9729) an enzyme from Acinetobacter sp. RS1 that reduced 9 to 10. Gregory C. Fu of Caltech developed (Angew. Chem. Int. Ed. 2014, 53, 13183) a phosphine catalyst that directed the addition of 12 to 11 to give 13. Armido Studer of the Westfälische Wilhelms-Universität Münster showed (Angew. Chem. Int. Ed. 2014, 53, 9622) that 15 could be added to 14 to give 16 in high ee. Akkattu T. Biju of CSIR-National Chemical Laboratory described (Chem. Commun. 2014, 50, 14539) related results. The photostimulated enantioselective ketone alkylation developed (Chem. Sci. 2014, 5, 2438) by Paolo Melchiorre of ICIQ was powerful enough to enable the alkylation of 17 with 18 to give 19, overcoming the stereoelectronic preference for axial bond formation. David W. Lupton of Monash University established (J. Am. Chem. Soc. 2014, 136, 14397) the organocatalyzed transformation of the dienyl ester 20 to 21. James McNulty of McMaster University added (Angew. Chem. Int. Ed. 2014, 53, 8450) azido acetone 23 to 22 to give 24 in high ee. There are sixteen enantiomerically-pure diastereomers of the product 27. John C.-G. Zhao of the University of Texas at San Antonio showed (Angew. Chem. Int. Ed. 2014, 53, 7619) that with the proper choice of organocatalyst, with or without subsequent epimerization, it was possible to selectively prepare any one of eight of those diastereomers by the addition of 26 to 25. William P. Malachowski of Bryn Mawr College showed (Tetrahedron Lett. 2014, 55, 4616) that 28, readily prepared by a Birch reduction protocol, was converted by heating followed by exposure to catalytic Me3P to the angularly-substituted octalone 29.
2
Ramos, Jaciara Andrade, Karina Ferrazzoli Devienne Vicentine et Afonso Pelli. « The effect of noise pollution on animal welfare - a case study in balb/c mice ». Dans COLLECTION OF INTERNATIONAL TOPICS IN HEALTH SCIENCE- V1. Seven Editora, 2023. http://dx.doi.org/10.56238/colleinternhealthscienv1-083.
Texte intégralRésumé :
The quality of life is determined primarily by the quality of the environment. Many variables act on the environment, including noise pollution, present in everyday life. According to the World Health Organization, above 55 db, the body begins to suffer the impact of noise, causing mild stress and excitement. One of the main responses is activation of the hypothalamic-pituitary-adrenal axis, causing the release of glucocorticoids. These hormones act on the energy metabolism, increasing the amount of free fatty acids in the bloodstream. Thus, changes in lipid metabolism have been reported after stressful situations. In this experiment we used Mus musculus balb/c mice submitted to chronic sound stress, at 90dB, for 30 days, at night, from 8 pm to 2 am the next day. The animals were euthanized by decapitation after anesthesia, and the blood collected was used to measure cholesterol, triglycerides, and glucose. During the experiment the animals' weight was monitored, and there was no considerable variation between the control and experimental groups. Regarding the biochemical parameters, there were statistically significant differences in the levels of cholesterol, triglycerides, and glucose. The significance levels, or p values, were 0.067 (p less than 6.7%); 0.053 (p less than 5.3%), and 0.000 (p less than 0.0009%), respectively. With the present study, it can be concluded that stress hormones interfere with cholesterol, triglyceride and glucose metabolism. The chronic noise stress model can be considered a good environmental stress model that mimics urban stress.
3
Petty, Wayne. « C. P. E. Bach and the fine art of transposition ». Dans Schenker Studies 2, 49–66. Cambridge University Press, 1999. http://dx.doi.org/10.1017/cbo9780511470295.006.
Texte intégral
4
Taber, Douglass F. « Enantioselective Synthesis of Alcohols and Amines : The Doi Synthesis of Apratoxin C ». Dans Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0034.
Texte intégralRésumé :
Hiromitsu Takayama of Chiba University used (Org. Lett. 2014, 16, 5000) the Itsuno-Corey protocol to reduce the enone 1 to the allylic alcohol 2. Peiming Gu of Ningxia University developed (Org. Lett. 2014, 16, 5339) a Cu catalyst that cyclized the prochiral 3 to 4 in high ee. Xiaoming Feng of Sichuan University effected (Org. Lett. 2014, 16, 3938) enantioselective Baeyer–Villiger oxidation of the racemic cyclopentanone 5, converting one enantiomer to the δ-lactone 6. The velocity of catalytic osmylation is often limited by slow turnover of the intermediate osmate ester. Koichi Narasaka, then at the University of Tokyo, showed (Chem. Lett. 1988, 1721) that the efficiency of the transformation was improved by the addition of stoichiometric phenyl boronic acid. Kilian Muñiz, now at ICIQ Tarragona, established (Chem. Eur. J. 2005, 11, 3951) that this acceleration also worked with Sharpless asymmetric dihydroxylation. D. Christopher Braddock of Imperial College London took advantage (Chem. Commun. 2014, 50, 13725) of these observations, converting myrcene 7 selectively to the cyclic boronate 8. Michael P. Doyle of the University of Maryland developed (J. Org. Chem. 2014, 79, 12185) a Rh catalyst for the ene reaction of 9 with 10 to give 11. Adriaan J. Minnaard of the University of Groningen devised (Chem. Eur. J. 2014, 20, 14250) a Cu catalyst that mediated the face selective addition of 13 to 12, establishing the oxygenated quaternary center of 14. Tomonori Misaki and Takashi Sugimura of the University of Hyogo used (Chem. Lett. 2014, 43, 1826) Michael addition of 15 to 16 to construct the oxygenated quaternary center of 17. Jon C. Antilla of the University of South Florida assembled (Chem. Commun. 2014, 50, 14187) the δ-lactone 20 by adding the diene 19 to the α-keto ester 18. Zhiyong Wang of the University of Science and Technology of China reported (Org. Lett. 2014, 16, 3564) related results. Jonathan A. Ellman of Yale University achieved (Angew. Chem. Int. Ed. 2014, 53, 11329) substantial enantioselectivity in the addition of thioacetic acid 22 to the nitroalkene 21 to give 23. Subhash P. Chavan of the National Chemistry Laboratory prepared (Tetrahedron Lett. 2014, 55, 5905) the allylic amine 25 by reduction of the aziridine 24.
5
Pearson, Ronald K. « The Art of Model Development ». Dans Discrete-time Dynamic Models. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780195121988.003.0010.
Texte intégralRésumé :
The primary objective of this book has been to present a reasonably broad overview of the different classes of discrete-time dynamic models that have been proposed for empirical modeling, particularly in the process control literature. In its simplest form, the empirical modeling process consists of the following four steps: 1. Select a class C of model structures 2. Generate input/output data from the physical process P 3. Determine the model M ∊ C that best fits this dataset 4. Assess the general validity of the model M. The objective of this final chapter is to briefly examine these four modeling steps, with particular emphasis on the first since the choice of the model class C ultimately determines the utility of the empirical model, both with respect to the application (e.g., the difficulty of solving the resulting model-based control problem) and with respect to fidelity of approximation. Some of the basic issues of model structure selection are introduced in Sec. 8.1 and a more detailed treatment is given in Sec. 8.3, emphasizing connections with results presented in earlier chapters; in addition, the problem of model structure selection is an important component of the case studies presented in Secs. 8.2 and 8.5. The second step in this procedure—input sequence design—is discussed in some detail in Sec. 8.4 and is an important component of the second case study (Sec. 8.5). The literature associated with the parameter estimation problem—the third step in the empirical modeling process—is much too large to attempt to survey here, but a brief summary of some representative results is given in Sec. 8.1.1. Finally, the task of model validation often depends strongly on the details of the physical system being modelled and the ultimate application intended for the model. Consequently, detailed treatment of this topic also lies beyond the scope of this book but again, some representative results are discussed briefly in Sec. 8.1.3 and illustrated in the first case study (Sec. 8.2). Finally, Sec. 8.6 concludes both the chapter and the book with some philosophical observations on the problem of developing moderate-complexity, discrete-time dynamic models to approximate the behavior of high-complexity, continuous-time physical systems.
6
Leenes, Ronald. « Article 43 Certification bodies ». Dans The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0082.
Texte intégralRésumé :
Recital 77; Article 5(2) (Principle of accountability); Article 42 (Certification); Article 55 (Competence of the supervisory authorities); Article 56 (Competence of the lead supervisory authority); Articles 57(1)(p)–(q) (Tasks of the supervisory authorities); Article 58(3)(e) (Powers of the supervisory authorities); Article 63 (Consistency mechanism); Article 64(1)(c) (Opinions of the board); Article 70(1)(o)–(q) (Tasks of the board) (see too recital 77); Article 92 (Exercise of delegated acts by Commission) (see too recitals 166 and 168).
7
Taber, Douglass F. « Alkaloid Synthesis : Penaresidin A (Subba Reddy), Allokainic Acid (Saicic), Sedacryptine (Rutjes), Lepistine (Yokoshima/Fukuyama), Septicine (Hanessian), Lyconadin C (Dai) ». Dans Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0058.
Texte intégralRésumé :
Penaresidin A 3, isolated from the Okinawan marine sponge Penares sp., is a potent activator of actomyosin ATPase. B. V. Subba Reddy of the Indian Institute of Chemical Technology prepared (Tetrahedron Lett. 2014, 55, 49) the azetidine ring of 3 by mesylation of the hydroxy sulfonamide 2, derived from 1, followed by cyclization. Allokainic acid 6 has become a useful tool for neurological studies. Radomir N. Saicic of the University of Belgrade found (Org. Lett. 2014, 16, 34) that the Tsuji–Trost cyclization of 4 to 5 proceeded with high diastereoselectivity, presumably by way of the enamine of the aldehyde. Floris P. J. T. Rutjes of Radboud University Nijmegen prepared (Org. Lett. 2014, 16, 2038) the starting material 7 for (−)-sedacryptine 9 via an enantioselective Mannich addition. The reagent of choice for the Aza–Achmatowicz rearrangement of 7 to 8 proved to be mCPBA. The intriguing tricyclic alkaloid (−)-lepistine 12 was isolated from the mushroom Clitocybe fasciculate. En route to the first-ever synthesis of 12, Satoshi Yokoshima and Tohru Fukuyama of Nagoya University cyclized (Org. Lett. 2014, 16, 2862) the glycidol-derived sulfonamide 10 to the azacycle 11. (+)-Septicine 15 is the biogenetic precursor to the phenanthrene alkaloid (+)-tylophorine. Stephen Hanessian of the Université de Montréal prepared (Org. Lett. 2014, 16, 232) 15 by condensing the proline-derived ketone 13 with the aldehyde 14. Mingji Dai of Purdue University elaborated (Angew. Chem. Int. Ed. 2014, 53, 3922) the amine 16 to the enone 17 by intramolecular Mannich alkylation followed by methylenation and allylic oxidation. Condensation with the sulfoxide 18 then delivered lyconadin C 19.
8
« Questions Q 55-1 Under what circumstances does Art. 55 CISG apply ? Q 55-2 a) Divide the corresponding provisions from the other legal systems into two groups, a rather liberal group which allows for a contract where the contract price has not been determined, and a group representing a rather narrow interpretation. b) Where, on a scale from very strict to flexible provisions, would you place Art. 55 CISG ? Q 55-3 a) Sometimes, courts or tribunals try to determine a missing price with a view to ‘saving’ the contract or rendering it effective. Under which circumstances will there definitely be no contract under the CISG, notwithstanding the possibility provided by Art. 55 ? b) In which of the provisions from other legal systems stated above is this legal position made particularly clear ? Q 55-4 a) How is the missing contract price to be determined under Art. 55 CISG ? b) To what do the other legal provisions refer ? c) On the determination of the sales price, read, in particular, Art. 57 ULIS. What changes have been made in Art. 55 CISG ? Is there another domestic sales law provision providing for a similar solution to Art. 57 ULIS ? Is there still a difference between Art. 57 ULIS and that other domestic rule ? d) Do you regard Art. 55 CISG as giving quite clear instructions on how to establish the missing purchase price ? Cf. with Art. 5.7 UP 2004, Art. 6:104 PECL. Q 55-5 What happens if there is no contract price ascertainable ? » Dans International Sales Law, 461–65. Routledge-Cavendish, 2007. http://dx.doi.org/10.4324/9780203945445-150.
Texte intégral
9
« Twiggs, op. cit. 28 Freud, S. (1917) Introductory Lectures on Psychoanalysis, Harmondsworth : Penguin, 1974, p.496 29 Rogers, C. (1987) Reflection of feelings and transference. In H. Kirschenbaum & ; V.L. Henderson (eds) The Carl Rogers Reader, London : Constable, 1990, p.134 30 Twiggs, op. cit. 31 Haule, J. The Love Cure, Therapy Erotic and Sexual, Dallas : Spring, 1996, p.55 32 Schwartz-Salant, S. The Mystery of Human Relationships : Alchemy and the Transformation of Self, London : Routledge, 1998, p.2 33 Ibid., p.112 34 Donleavy, P. Analysis and Erotic Energies in The Interactive Field In Analysis, Illinois : Chiron, 1995, p.110 35 Casement, P. On Learning from the Patient, London : Routledge, 1985 36 Laing, R.D. The Facts of Life, op. cit., p.110 37 Jacoby, op. cit., p.109 38 Ussher, J. Women's madness : a material discursive intrapsychic approach. In D. Fee (ed) Pathology and Postmodernism, London : Sage, 2000, p.218 39 Parker, op. cit., p.36 40 Bruna-Seu, op. cit., p.206 41 Hollway, W. Gender difference and the production of subjectivity. In J. Henriques, W. Hollway, C. Urwin, C. Venn, V. Walkerdine (eds) Changing the subject : Psychology, Social Regulation and Subjectivity, London : Routledge, 1984 42 Harper, D.J. Discourse analysis and 'mental health'. Journal of Mental Health,1995, 4, 347-357 43 Billig, op. cit. 44 Bordieu, P. Pascalian Meditations, Cambridge : Polity Press, 2000 45 Phillips, R. The need for research-based midwifery practice. British Journal of Midwifery, 1994, 2, 7, 335-8 46 Goodband, S. Research is the new nursing ritual. Nursing Times, 2001, 97, 25, p.21 ». Dans Deconstructing Evidence-Based Practice, 154. Routledge, 2004. http://dx.doi.org/10.4324/9780203422311-25.
Texte intégral
10
« n ar eegattaikveenco to rr e im la p ti loynsa , p th hy essieca ‘ ltelliencko nnectio key va between ntphaet te lo rn ca s l ’ w (1 a9s7o2n ). tFhoellpoowiinntgosfoemmeeirngc in on gcilsusc iv oentw ai onrekdbiynoLtahm er bsm Gl aapnstzrioeatblael . a1n9d9t1h ) e . widely distributed one (e.g., see (e.g., by Berlage and DeBoer 1960), Professor Jacob pressure f an pdr ec wiapsi ta atiW on a , l ke te r m produced teleconnection Bjerknes at the University of California at Los modes of interannual blcel im to a te idve perature, and surface Angeles made the key step forward by demonstrating nise today, including the South anerrita if nbyi li tthyethlaatrgweestre scale that the atmospheric teleconnection patterns were North Atlantic O Oscillation and c o th g e p eq a u rt atoof ri aalcPoaucp if liecdOmco ea dneaonfdinttheer ac gtlioobnalbaettmwo ee sp nhteh re e was Inaba le d d to it icoanr ry to scb illation. (Bjerknes 1966, 1969, and 1972). It is now clear that of fortunate circu omuste ing a first-rate scientist, Walker other parts of the global ocean also participate in the the art of statistics htaahn is work because of a confluence Southern Oscillation, manifested through changes in matical tool of the ob d se cdeesv . e F lo ir pset, shortly beforehand, sea surface temperature and the overlying atmos also a very ab rvational dscriaepnicdelsy . aWsaalkm er atwhaes phe B ri ycctih rc e u la la ti toen. 1970s and early 1980s, climate o st fat ti hse ti cIsnd (W ian alM ker le1 99 m7a ) t . h H em av aitn ic giatn ak ewn ho understood scientists were able to document the relationships gained the oppo ertteuonrio ty lo tgoicc al Departme th netijnob19o0f3h , e h ad ehRyap sm ot uhsesso is neda nd byCaB rp je ernktneers 19 in 8 2, mwoh re odd is e c ta uisls ed (e . tgh . e , m re aqtuhierm ed ata ic a la l rg oepesrta aff capab alreryoofupteh rf is orsm tu idniges, m w an h u ic ahlT So hue th ceorunplO ed sco il cleaa ti n o -n a / tEmlosNpihneoreasvaaricao ti uopnlecdenstyrsetdemo ) n . W ve a ry lk p er raw ct ais able to t m io ankseoanmeax jo te rne si f v fo e rt d a to ta so se lv ts e . tShoeE th NeSeO qu a ( t E or l ia NlP in ac o i / f S ic oiustnhoew rn co Omsm cil oln at liyon re ), f er a r ed p h to ra saesA ra n in oftah ll e , rkaencaalcp ti rvoib ty le m th aotfh pr aed dicting Indian monsoon coined in planning documents for the international by the earl yyfyaecatrosrowfasthtehattwietnh sta taidejru te t st dbe in c om th eep1 os 8s7i0 bl s e . Tmreonpti . caDlO ur cienagntG he lo b 1 al 98A0tsmoasnpdh er 1e99 (T 0s OGaAs ) ereix es p er o i flsaurfgfe ic -s ie cnatlence li amr-agtleob va arl ia d ti aotnas . to de hsccre ib n e tu raynd to agnaatlh ys eereom ur p iri ucnadl, e m rs o ta dned ll iinngg , aonfdtthheeo re p ti hcyaslicsa tu l di m es e c in hcarneiassm ed s 192 T3heansdtu1d9 ie 2s4 , bWyaW lk a e lker and others (e.g., Walker aad ss voacnicae te sdinwiutnhdEeN rs S ta O n . diAngdettealielceodndnie sc c u ti sosn io pnao tt ferrencsen in trge lo la b ti aol) nsshuirp fa s ce exp is re te s d su rbeertawnedenB li lsasrg1e9 -s 3c2a ) le s h ( o i. w e. e , d n that the TOGA era (1985-94) can be found in Trenberth patterns -in particular, tphaettIen rn d s ia n an sdum re m gional rain efaarl -l et aTl. h1e 99 i8deanntd if i A ca ll tainone ta o l. f 19 so 9m6. e of the physical v ra aitn io fa nlal. l W ev a id lk eenrc ’s erfeosreatrhcehepxrio st veindceedo th feefr monso an ir osrtgaonbisseorn m rev ec it h a anism ed conne l c is t e io dnsi nt aesrseosct iated with patterns. in A W se a ri lekser’ osENfp SO has st ruedciiepsi ta w ti i o th n g re te alte ly -glo more wHoerbcaal-ls le cda le tpk did no hi tsattthee rn hav Soofuitnh terannual climate variability. complete data sets (e.g., Kiladis and Diaz 1989 ; expected because, efotrhe re a im e p rn acOt scillatio sons th tahtartemma ig n. htI in unh itia nc alveel ly ar b , e h th einsrReocpoenlfeiw rm sk eida se nvde ra Hlao lp f e th rt et1e9 le 8c6o , nn 1e9c8t7 io , ns ansdu gg 1e9s9 te 2 d ) c so o o rr n e la ptr io ec nispib ta et t w io enenwtehaekepnreed ss uarbeopuatt te th rn esta im nd e m th oene cboynW ne acltkieornsa . ndRootphee le rs w , saknidaindde nt H ifi aeldpeardt di ( t 1 io 9n8a7ltaen le-were discovered. Th y 1989) attempted to improve the usefulness of tele d taitmtehemomsitdodf le thoefetah rl eec tw or ernetliae ti tohncsesnttruernyg , th beuntebdyag th a a in tcdooncnuemce ti notn patterns y work ha ing regions foorfstehaesognlaolbcelitm ha att , eipnreaddidcittiioonnb to y fille Adc in ru c w ia alspaap rt hyosfictahleepxipcltaunrdebteheantfro em rg aoitn ten atio ed . to be a m ls e o re lhyadshroew la itn io gnssh ta itp is stiw ca ilthEN EN SO SO -p rtehca ip t it w at eiroenhliignhklsy , t te hleecSoonuntehcetrinonOp sc aitltleartn io s. n A ju rsetvaisewaonfk fo nrow th leedogbesaeb rv oeudticdoennstiisftieendttfhreom se aespoin so sdaend to reegpiiosn od seo . f T th h e ey g p lo a b rt eicw ul haerr ly physical explanation precipitation was associated with ENSO in at least 75 e ». Dans Droughts, 56. Routledge, 2016. http://dx.doi.org/10.4324/9781315830896-39.
Texte intégralActes de conférences sur le sujet "Art. 55 c. 2 c.p"
1
Sugimori, Daisuke, Kiyoto Kajiyama, Shunsuke Kawashima et Yuho Matsumoto. « Phosphatidylglycerol-specific Phospholipase C from Amycolatopsis Sp. NT115 : Biochemical Characterization and Heterologous Expression ». Dans 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fmmj5845.
Texte intégralRésumé :
In recent years, phosphatidylglycerol (PG) has been attracting attention in the field of cell physiology such as photosynthesis and germ cells, or clinical diagnosis. Most of phospholipids containing PG are analyzed using HPLC and LC-MS; however, it has been desired to develop an enzymatic assay method for determination of PG concentration in a simple, easy, and high-through put.In our presentation, biochemical characterization of a PG-specific phospholipase C (PG-PLC) from Amycolatopsis sp. NT115 will be reported. PG-PLC (molecular mass, 55 kDa) showed maximal activity at pH 6.0 and 55°C. PG-PLC showed almost no activity on other diacylphospholipids, dipalmitoylPG, lysoPG and glycerol 3-phosphate, demonstrating PG-PLC can recognize not only the substrate headgroup but also the acyl chains. PG-PLC was inhibited by Zn2+; however, it was hardly inhibited by EDTA and non-ionic surfactants such as Triton X-100, Tween 80, Briji 35 and Nonidet P-40. PG-PLC activity was enhanced by 1 mM Mn2+, Al3+, 0.1% sodium deoxycholate by 1.3-2.5 folds. Recombinant PG-PLC (rPG-PLC) was extracellularly produced using Streptomyces lividans/pUC702 expression system. However, unexpectedly it was produced with the N-terminal region deleted by ca. 230 amino acids. As a result, the stability of the deletion mutant (Δ230aa) was markedly decreased. In 96 h culture, rPG-PLC with His6-tag was produced with 0.188 U/mL and 3.36×10-2 U/mg-protein in the culture supernatant. Moreover, 1.52 mg-protein of the purified Δ220aa (2.5 U/mL, 16.4 U/mg-protein) was yielded from 0.9 L of the culture supernatant by His-tag affinity chromatography. Using the purified Δ220aa, kinetic parameters were determined to be Km=0.368 mM, 99.2 µM/min (6.51 mmol/min/mg-protein), kcat=5.29×10-2 s-1, kcat/Km=0.256 mM-1s-1 for POPG.
2
Baumgardner, Marc E., et Daniel B. Olsen. « Poison Build-up and Performance Degradation of an Oxidation Catalyst in 2-Stroke Natural Gas Engine Exhaust ». Dans ASME 2017 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icef2017-3550.
Texte intégralRésumé :
Due to current and future exhaust emissions regulations, oxidation catalysts are increasingly being added to the exhaust streams of large-bore, 2-stroke, natural gas engines. Such catalysts have been found to have a limited operational lifetime, primarily due to chemical (i.e. catalyst poisoning) and mechanical fouling resulting from the carry-over of lubrication oil from the cylinders. It is critical for users and catalyst developers to understand the nature and rate of catalyst deactivation under these circumstances. This study examines the degradation of an exhaust oxidation catalyst on a large-bore, 2-stroke, lean-burn, natural gas field engine over the course of 2 years. Specifically this work examines the process by which the catalyst was aged and tested and presents a timeline of catalyst degradation under commercially relevant circumstances. The catalyst was aged in the field for 2 month intervals in the exhaust slipstream of a GMVH-12 engine and intermittently brought back to the Colorado State Engines and Energy Conversion Laboratory for both engine testing and catalyst surface analysis. Engine testing consisted of measuring catalyst reduction efficiency as a function of temperature as well as the determination of the light-off temperature for several exhaust components. The catalyst surface was analyzed via SEM/EDS and XPS techniques to examine the location and rate of poison deposition. After 2 years on-line the catalyst light-off temperature had increased ∼55°F (31°C) and ∼34 wt% poisons (S, P, Zn) were built up on the catalyst surface, both of which represent significant catalyst deactivation.
3
Osbert, Ashaba, Samson Rwahwire et Yvonne Tusiimire. « Re-Engineering Plastic Waste for the Modification of Bitumen Blends ». Dans International Conference on Advances in Materials Science 2021. Switzerland : Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-31t6r8.
Texte intégralRésumé :
The increase in the production and utilization of plastics has created a never-ending problem of plastic waste. Developing countries face challenges with plastic waste disposal that in due process negatively impacts the environmental ecosystem. That notwithstanding, it suffices to mention that most developing countries have poor road networks that pose a burden towards smooth economic and social development. The problem is further exacerbated by the limited availability of bitumen which is usually imported but also has environmental concerns. It is against this background that we proposed alternative binders from plastic waste which can help developing countries to manage plastic waste as well as build road networks, thereby leading to sustainable development. We explored the 80/100 penetration grade bitumen modification (Penetration grade 85 and Softening temperature 46°C) using polyethylene terephthalate (PET) waste (2 – 12%) and lignin (0.2%) as a crosslinking agent by weight for every PET waste – Bitumen sample. The research showed that Plastic waste and lignin improved the performance of bitumen. The modified bitumen with 10% waste PET and 0.2% lignin enhanced the softening point and penetration points to 55°C and 46, respectively; hence the incorporation of PET and lignin provided better properties compared to the neat bitumen.
4
Chiesa, Paolo, Giovanni Lozza, Ennio Macchi et Stefano Consonni. « An Assessment of the Thermodynamic Performance of Mixed Gas-Steam Cycles : Part B — Water-Injected and Hat Cycles ». Dans ASME 1994 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/94-gt-424.
Texte intégralRésumé :
Part B of this paper focuses on intercooled recuperated cycles where water is injected to improve both efficiency and power output. This concept is investigated for two basic cycle configurations: a Recuperated Water Injected (RWI) cycle, where water is simply injected downstream the HP compressor, and a Humid Air Turbine (HAT) cycle, where air/water mixing is accomplished in a counter-current heat/mass transfer column called “saturator”. For both configurations we discuss the selection and the optimization of the main cycle parameters, and track the variations of efficiency and specific work with overall gas turbine pressure ratio and turbine inlet temperature (TIT). TIT can vary to take advantage of lower gas turbine coolant temperatures, but only within the capabilities of current technology. For HAT cycles we also address the modelization of the saturator and the sensitivity to the most crucial characteristics of novel components (temperature differences and pressure drops in heat/mass transfer equipment). The efficiency penalties associated to each process are evaluated by a second-law analysis which also includes the cycles considered in Part A. For any given TIT in the range considered (1250 to 1500°C), the more reversible air/water mixing mechanism realized in the saturator allows HAT cycles to achieve efficiencies about 2 percentage points higher than those of RWI cycles: at the TIT of 1500°C made possible by intercooling, state-of-the-art aero-engines embodying the above cycle modifications can reach net electrical efficiencies of about 57% and 55%, respectively. This compares to efficiencies slightly below 56% achievable by combined cycles based upon large-scale heavy duty machines with TIT = 1280°C.
5
Kribben, A., E. Fritschka, M. Sibold, M. Fassbender, A. Distler et Th Philipp. « EFFECT OF FUROSEMIDE ON PLATELET AGGREGATION AND ON ALPHA-ADRENOCEPTOR-DENSITY IN MAN. » Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643447.
Texte intégralRésumé :
Furosemide (FUR) reduces the ∝2-adrenoceptor- (∝2-R) mediated pressor effect of norepinephrine. Since it has been shown that FUR reduces platelet aggregation ( AGG) we studied the effect of FUR on α2-R as well as that on the ∝2-R-medi ated epinephrine ( EPI)-induced AGG a) ex vivo and b) in vitro. For comparison the effect of FUR on ADP-induced AGG was also studied. Methods: a) 8 normotensive men received FUR (30 mg b. i.d. ) for 3 weeks. EPI- (1 μmol/1) and ADP- (1 μmol/1) induced platelet AGG were measured before as well as after 3 weeks of FUR application with a semiautomatic device ( APACT) . Platelet ∝2-R-density was measured by 3H-yohimbine-binding and the fraction of high-affinity binding-sites was measured by competi tion of 3H-yohimbine with EPI. b) Platelet-rich plasma was incubated with FUR (1 mmol/1) for 10 min at 37 °C and AGG was measured (n=7) as described. Results: a) FUR decreased ∝2-R-densi ty from 293± 28 to 251±; 21 fmol/mg protein (p< 0.01) and high affinity binding sites from 64± 3 to 55± 5 % (p< 0.01). FUR inhibited ADP-induced AGG ex vivo while EPI-induced AGG did not change (table). b) In vitro FUR inhibited total ADP-induced AGG from 7 4 ± 4 to 45± 8 % (p< 0. 01) while again EPI-induced AGG did not change.Conclusions: The results suggest separate effects of FUR on α2 R-density and on platelet AGG. Although FUR decreased < r2-R, EPI-induced platelet AGG remained unchanged. Since FUR inhibited ADP-induced AGG ex vivo as well as in vitro FUR may interfere directly with the mechanism of ADP-induced platelet AGG.
6
Mehraban, Arash, Jed Brown, Henry Tufo, Jeremy Thompson, Rezgar Shakeri et Richard Regueiro. « Efficient Parallel Scalable Matrix-Free 3D High-Order Finite Element Simulation of Neo-Hookean Compressible Hyperelasticity at Finite Strain ». Dans ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-70768.
Texte intégralRésumé :
Abstract The paper investigates matrix-free high-order implementation of finite element discretization with p-multigrid preconditioning for the compressible Neo-Hookean hyperelasticity problem at finite strain on unstructured 3D meshes in parallel. We consider two formulations for the matrix-free action of the Jacobian in Neo-Hookean hyperelasticity: (i) working in the reference configuration to define the second Piola-Kirchhoff tensor as a function of the Green-Lagrange strain S(E) (or equivalently, the right Cauchy-Green tensor C = I+2E), and (ii) working in the current configuration to define the Kirchhoff stress in terms of the left Cauchy-Green tensor τ(b). The proposed efficient algorithm utilizes the Portable, Extensible Toolkit for Scientific Computation (PETSc), along with the libCEED library for efficient compiler optimized tensor-product-basis computation to demonstrate an efficient nonlinear solution algorithm. We utilize p-multigrid preconditioning on the high-order problem with algebraic multigrid (AMG) on the assembled linear Q1 coarse grid operator. In contrast to classical geometric multigrid, also known as h-multigrid, each level in p-multigrid is related to a different approximation polynomial order p, instead of the element size h. A Chebyshev polynomial smoother is used on each multigrid level. AMG is then applied to the assembled Q1 (trilinear hexahedral elements), which allows low storage that can be efficiently used to accelerate convergence to a solution. For the compressible Neo-Hookean hyperelastic constitutive model we exploit the stored energy density function to compute the stored elastic energy density of the Neo-Hookean material as it relates to the deformation gradient. Based on our formulation, we consider four different algorithms each with different storage strategies. Algorithms 1 and 3 are implemented in the reference and current configurations respectively and store ∇Xξ, det(∇ξX), and ∇Xu. Algorithm 2 in the reference configuration stores, ∇Xξ, det(∇ξX), ∇Xu, C−1, and λ log (J). Algorithm 4, in the current configuration, stores det(∇ξX), ∇xξ, τ, and μ – λ log(J). x refers to the current coordinates, X to the reference coordinates, and ξ to the natural coordinates. We perform 3D bending simulations of a tube composed of aluminum (modulus of elasticity E = 69 GPa, Poisson’s ratio v = 0.3) using unstructured meshes and polynomials of order p = 1 through p = 4 under mesh refinement. We explore accuracy-time-cost tradeoffs for the prediction of strain energy across the range of polynomial degrees and Jacobian representations. In all cases, Algorithm 4 using the current configuration formulation outperforms the other three algorithms and requires less storage. Similar simulations for large deformation compressible Neo-Hookean hyperelasticity as applied to the same aluminum material are conducted with ABAQUS, a commercial finite element software package which is a state-of-the-art engineering software package for finite element simulations involving large deformation. The best results from the proposed implementations and ABAQUS are compared in the case of p = 2 on an Intel system with @2.4 GHz and 128 GB RAM. Algorithm 4 outperforms ABAQUS for polynomial degree p = 2.
7
Kempfer, A. C., N. Maugeri, C. Farías, E. Bermejo, M. Gimeno et M. Lazzari. « PURIFICATION AND PARTIAL CHARACTERIZATION OF A BIOACTIVE SUBSTANCE FROM RAT'S VESSEL WALL INDEPENDENT OF PROSTACYCLIN PRODUCTION ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643362.
Texte intégralRésumé :
Our previous observations provided evidence that a bioactive substance (BAS) with inhibitory effect on platelet aggregation and with inotropic activity on smooth muscle preparations is present in aortic wall of rats treated previously with indomethacin. The ability to inhibit platelet aggregation was used for monitoring its purification and partial characterization. The original sample was extracted by rinsing aortic rings (1.5 mg dried rings) in buffer Krebs (300 μl) for 40 minutes at room temperature. The substance was purified by gel filtration (Bio-gel P-30, Sephadex G-100, Sephadex G-75) and ion exchange chromagra-phy (DEAE cellulose). In the last method, salt gradient elution was performed. Further purification by Sephadex G-50 resulted in removal of 90% of the contaminating substances without a loss of inhibitory activity. The main peak of both chromatographic procedures was analyzed on SDS-PAGE and PAGE with denaturing solvents. The substance was evident by Coomassie Brilliant Blue and periodic acid Schiff staining.In order to determine if the BAS was susceptible to proteolysis, an aliquot of the original sample (29 ug total protein) was incubated with trypsin (final concentration 0.3 μg/ml) and with chymotrypsin (final concentration 3 μg/ml). The BAS activity was not detected. An aliquot of the same original sample was incubated with neuraminidase (final concentration 1.2 units). The BAS activity was detected.The substance appeared to be stable for at least 18 hours at room temperature and 2 hours at 37°C, In addition it was stable over a pH range between 6.8 to 8.6, showing an anionic behaviour.The protein concentration of this substance determined by the method of Lowry was 1 μg/mlPartial characterization supports the conclusion that the substance present in aortic wall of rats is a homogeneous protein, which has a molecular size estimated at 55-65 kDa.
8
Prueter, Phillip E., Katelyn J. Smith, Brian Macejko et Kraig S. Shipley. « Commentary on Recent Changes in ASME B31.3 Post Weld Heat Treatment Requirements and the Effectiveness of Weld Preheat ». Dans ASME 2017 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/pvp2017-65859.
Texte intégralRésumé :
The 2014 Edition of ASME B31.3, Process Piping [1], introduced significant changes to the post weld heat treatment (PWHT) requirements for P-No. 1 carbon steel materials. In particular, PWHT is no longer a mandatory requirement for any wall thickness provided that multi-pass welding is employed for wall thicknesses greater than 5 mm (3/16 of an inch) and a minimum preheat of 95°C (200°F) is implemented for wall thicknesses greater than 25 mm (1 inch). Detailed fracture mechanics analyses have shown that the lack of a mandatory PWHT requirement for thicker P-No. 1 components may result in a significant increase in risk for brittle fracture failures due to near-yield level weld residual stresses. Given the concern throughout the pressure vessel and piping community regarding potential brittle fracture failures, this updated PWHT guidance is examined. Impact testing requirements and exemption curves were introduced in the 1987 Addenda [2] of ASME Section VIII Division 1 (VIII-1) [3] in Paragraph UCS-66 and extended into ASME Section VIII Division 2 (VIII-2) [4]. During the VIII-2 rewrite in 2007 [5], the available technical and historical basis for the UCS-66 exemption curves was examined and improved to reflect modern fracture mechanics standards. The result of that effort was a systematic approach that can be modified for particular geometries and assumed flaws, if desired. The method used the most modern, fracture mechanics approach for welds in API 579-1/ASME FFS-1, Fitness-For-Service, (API 579) [6] based on the failure assessment diagram (FAD). As a result of explicitly accounting for weld residual stress, two separate sets of exemption curves are provided in VIII-2 [4]; one set for as-welded components and another set for PWHT components. In this paper, a similar approach is summarized to generate exemption curves by establishing newer as-welded and PWHT curves using the Fracture Toughness Master Curve (Master Curve) as documented in upcoming Welding Research Council (WRC) Bulletin 562 [7]. The increased propensity for brittle fracture in as-welded components versus PWHT components is clearly highlighted using this approach. The Master Curve, in conjunction with the elastic-plastic fracture mechanics employed in API 579 [6] provides a means to develop exemptions curves anchored in state-of-the-art fracture toughness technology that can be directly tied to different reference flaw sizes. Additionally, commentary on the appropriateness of the current ASME B31.3 [1] PWHT requirements is offered and the effectiveness of using weld preheat in lieu of PWHT as permitted in the National Board Inspection Code (NBIC) [8] is examined using simplified computational weld analysis.
9
Cmeciu, Doina, et Camelia Cmeciu. « VIRTUAL MUSEUMS - NON-FORMAL MEANS OF TEACHING E-CIVILIZATION/CULTURE ». Dans eLSE 2013. Carol I National Defence University Publishing House, 2013. http://dx.doi.org/10.12753/2066-026x-13-108.
Texte intégralRésumé :
Considered repositories of objects(Cuno 2009), museums have been analysed through the object-oriented policies they mainly focus on. Three main purposes are often mentioned: preservation, dissemination of knowledge and access to tradition. Beyond these informative and cultural-laden functions, museums have also been labeled as theatres of power, the emphasis lying on nation-oriented policies. According to Michael F. Brown (2009: 148), the outcome of this moral standing of the nation-state is a mobilizing public sentiment in favour of the state power. We consider that the constant flow of national and international exhibitions or events that could be hosted in museums has a twofold consequence: on the one hand, a cultural dynamics due to the permanent contact with unknown objects, and on the other hand, some visibility strategies in order to attract visitors. This latter effect actually embodies a shift within the perception of museums from entities of knowledge towards leisure environments. Within this context where the concept of edutainment(Eschach 2007) seems to prevail in the non-formal way of acquiring new knowledge, contemporary virtual museums display visual information without regard to geographic location (Dahmen, Sarraf, 2009). They play ?a central role in making culture accessible to the mass audience(Carrazzino, Bergamasco 2010) by using new technologies and novel interaction paradigms. Our study will aim at analyzing the way in which civilization was e-framed in the virtual project ?A History of the World in 100 Objects, run by BBC Radio 4 and the British Museum in 2010. The British Museum won the 2011 Art Fund Prize for this innovative platform whose main content was created by the contributors (the museums and the members of the public). The chairman of the panel of judges, Michael Portillo, noted that the judges were impressed that the project used digital media in ground-breaking and novel ways to interact with audiences. The two theoretical frameworks used in our analysis are framing theories and critical discourse analysis. ?Schemata of interpretation? (Goffman 1974), frames are used by individuals to make sense of information or an occurrence, providing principles for the organization of social reality? (Hertog & McLeod 2001). Considered cultural structures with central ideas and more peripheral concepts and a set of relations that vary in strength and kind among them? (Hertog, McLeod 2001, p.141), frames rely on the selection of some aspects of a perceived reality which are made more salient in a communicating text or e-text. We will interpret this virtual museum as a hypertext which ?makes possible the assembly, retrieval, display and manipulation? (Kok 2004) of objects belonging to different cultures. The structural analysis of the virtual museum as a hypertext will focus on three orders of abstraction (Kok 2004): item, lexia, and cluster. Dividing civilization into 20 periods of time, from making us human (2,000,000 - 9000 BC) up to the world of our making (1914 - 2010 AD), the creators of the digital museum used 100 objects to make sense of the cultural realities which dominated our civilization. The History of the World in 100 Objects used images of these objects which can be considered ?as ideological and as power-laden as word (Jewitt 2008). Closely related to identities, ideologies embed those elements which provide a group legitimation, identification and cohesion. In our analysis of the 100 virtual objects framing e-civilization we will use the six categories which supply the structure of ideologies in the critical discourse analysis framework (van Dijk 2000: 69): membership, activities, goals, values/norms, position (group-relations), resources. The research questions will focus on the content of this digital museum: (1) the types of objects belonging to the 20 periods of e-civilization; (2) the salience of countries of origin for the 100 objects; (3) the salience of social practices framed in the non-formal teaching of e-civilization/culture; and on the visitors? response: (1) the types of attitudes expressed in the forum comments; (2) the types of messages visitors decoded from the analysis of the objects; (3) the (creative) value of such e-resources. References Brown, M.F. (2009). Exhibiting indigenous heritage in the age of cultural property. J.Cuno (Ed.). Whose culture? The promise of museums and the debate over antiquities (pp. 145-164), Princeton, Oxford: Princeton University Press. Carrazzino, M., Bergamasco, M. (2010). Beyond virtual museums: Experiencing immersive virtual reality in real museums. Journal of Cultural Heritage, 11, 452-458. Cuno, J. (2009) (Ed.). Whose culture? The promise of museums and the debate over antiquities (pp. 145-164), Princeton, Oxford: Princeton University Press. Dahmen, N. S., & Sarraf, S. (2009, May 22). Edward Hopper goes to the net: Media aesthetics and visitor analytics of an online art museum exhibition. Visual Communication Studies, Annual Conference of the International Communication Association, Chicago, IL. Eshach, H. (2007). Bridging in-school and out-of-school learning: formal, non-formal, and informal education . Journal of Science Education and Technology, 16 (2), 171-190. Goffman, E. (1974). Frame analysis: An essay on the organization of experience. Cambridge, MA: Harvard University Press. Hertog, J.K., & McLeod, D. M. (2001). A multiperspectival approach to framing analysis: A field guide. In S.D. Reese, O.H. Gandy, & A.E. Grant (Eds.), Framing public life: Perspective on media and our understanding of the social world (pp. 139-162). Mahwah, NJ: Lawrence Erlbaum Associates. Jewitt, C. (2008). Multimodality and literacy in school classrooms. Review of Research in Education, 32 (1), 241-267. Kok, K.C.A. (2004). Multisemiotic mediation in hypetext. In Kay L. O?Halloren (Ed.), Multimodal discourse analysis. Systemic functional perspectives (pp. 131-159), London: Continuum. van Dijk, T. A. (2000). Ideology ? a multidisciplinary approach. London, Thousand Oaks, New Delhi: Sage.
Rapports d'organisations sur le sujet "Art. 55 c. 2 c.p"
1
Rankin, Nicole, Deborah McGregor, Candice Donnelly, Bethany Van Dort, Richard De Abreu Lourenco, Anne Cust et Emily Stone. Lung cancer screening using low-dose computed tomography for high risk populations : Investigating effectiveness and screening program implementation considerations : An Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the Cancer Institute NSW. The Sax Institute, octobre 2019. http://dx.doi.org/10.57022/clzt5093.
Texte intégralRésumé :
Background Lung cancer is the number one cause of cancer death worldwide.(1) It is the fifth most commonly diagnosed cancer in Australia (12,741 cases diagnosed in 2018) and the leading cause of cancer death.(2) The number of years of potential life lost to lung cancer in Australia is estimated to be 58,450, similar to that of colorectal and breast cancer combined.(3) While tobacco control strategies are most effective for disease prevention in the general population, early detection via low dose computed tomography (LDCT) screening in high-risk populations is a viable option for detecting asymptomatic disease in current (13%) and former (24%) Australian smokers.(4) The purpose of this Evidence Check review is to identify and analyse existing and emerging evidence for LDCT lung cancer screening in high-risk individuals to guide future program and policy planning. Evidence Check questions This review aimed to address the following questions: 1. What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? 2. What is the evidence of potential harms from lung cancer screening for higher-risk individuals? 3. What are the main components of recent major lung cancer screening programs or trials? 4. What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Summary of methods The authors searched the peer-reviewed literature across three databases (MEDLINE, PsycINFO and Embase) for existing systematic reviews and original studies published between 1 January 2009 and 8 August 2019. Fifteen systematic reviews (of which 8 were contemporary) and 64 original publications met the inclusion criteria set across the four questions. Key findings Question 1: What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? There is sufficient evidence from systematic reviews and meta-analyses of combined (pooled) data from screening trials (of high-risk individuals) to indicate that LDCT examination is clinically effective in reducing lung cancer mortality. In 2011, the landmark National Lung Cancer Screening Trial (NLST, a large-scale randomised controlled trial [RCT] conducted in the US) reported a 20% (95% CI 6.8% – 26.7%; P=0.004) relative reduction in mortality among long-term heavy smokers over three rounds of annual screening. High-risk eligibility criteria was defined as people aged 55–74 years with a smoking history of ≥30 pack-years (years in which a smoker has consumed 20-plus cigarettes each day) and, for former smokers, ≥30 pack-years and have quit within the past 15 years.(5) All-cause mortality was reduced by 6.7% (95% CI, 1.2% – 13.6%; P=0.02). Initial data from the second landmark RCT, the NEderlands-Leuvens Longkanker Screenings ONderzoek (known as the NELSON trial), have found an even greater reduction of 26% (95% CI, 9% – 41%) in lung cancer mortality, with full trial results yet to be published.(6, 7) Pooled analyses, including several smaller-scale European LDCT screening trials insufficiently powered in their own right, collectively demonstrate a statistically significant reduction in lung cancer mortality (RR 0.82, 95% CI 0.73–0.91).(8) Despite the reduction in all-cause mortality found in the NLST, pooled analyses of seven trials found no statistically significant difference in all-cause mortality (RR 0.95, 95% CI 0.90–1.00).(8) However, cancer-specific mortality is currently the most relevant outcome in cancer screening trials. These seven trials demonstrated a significantly greater proportion of early stage cancers in LDCT groups compared with controls (RR 2.08, 95% CI 1.43–3.03). Thus, when considering results across mortality outcomes and early stage cancers diagnosed, LDCT screening is considered to be clinically effective. Question 2: What is the evidence of potential harms from lung cancer screening for higher-risk individuals? The harms of LDCT lung cancer screening include false positive tests and the consequences of unnecessary invasive follow-up procedures for conditions that are eventually diagnosed as benign. While LDCT screening leads to an increased frequency of invasive procedures, it does not result in greater mortality soon after an invasive procedure (in trial settings when compared with the control arm).(8) Overdiagnosis, exposure to radiation, psychological distress and an impact on quality of life are other known harms. Systematic review evidence indicates the benefits of LDCT screening are likely to outweigh the harms. The potential harms are likely to be reduced as refinements are made to LDCT screening protocols through: i) the application of risk predication models (e.g. the PLCOm2012), which enable a more accurate selection of the high-risk population through the use of specific criteria (beyond age and smoking history); ii) the use of nodule management algorithms (e.g. Lung-RADS, PanCan), which assist in the diagnostic evaluation of screen-detected nodules and cancers (e.g. more precise volumetric assessment of nodules); and, iii) more judicious selection of patients for invasive procedures. Recent evidence suggests a positive LDCT result may transiently increase psychological distress but does not have long-term adverse effects on psychological distress or health-related quality of life (HRQoL). With regards to smoking cessation, there is no evidence to suggest screening participation invokes a false sense of assurance in smokers, nor a reduction in motivation to quit. The NELSON and Danish trials found no difference in smoking cessation rates between LDCT screening and control groups. Higher net cessation rates, compared with general population, suggest those who participate in screening trials may already be motivated to quit. Question 3: What are the main components of recent major lung cancer screening programs or trials? There are no systematic reviews that capture the main components of recent major lung cancer screening trials and programs. We extracted evidence from original studies and clinical guidance documents and organised this into key groups to form a concise set of components for potential implementation of a national lung cancer screening program in Australia: 1. Identifying the high-risk population: recruitment, eligibility, selection and referral 2. Educating the public, people at high risk and healthcare providers; this includes creating awareness of lung cancer, the benefits and harms of LDCT screening, and shared decision-making 3. Components necessary for health services to deliver a screening program: a. Planning phase: e.g. human resources to coordinate the program, electronic data systems that integrate medical records information and link to an established national registry b. Implementation phase: e.g. human and technological resources required to conduct LDCT examinations, interpretation of reports and communication of results to participants c. Monitoring and evaluation phase: e.g. monitoring outcomes across patients, radiological reporting, compliance with established standards and a quality assurance program 4. Data reporting and research, e.g. audit and feedback to multidisciplinary teams, reporting outcomes to enhance international research into LDCT screening 5. Incorporation of smoking cessation interventions, e.g. specific programs designed for LDCT screening or referral to existing community or hospital-based services that deliver cessation interventions. Most original studies are single-institution evaluations that contain descriptive data about the processes required to establish and implement a high-risk population-based screening program. Across all studies there is a consistent message as to the challenges and complexities of establishing LDCT screening programs to attract people at high risk who will receive the greatest benefits from participation. With regards to smoking cessation, evidence from one systematic review indicates the optimal strategy for incorporating smoking cessation interventions into a LDCT screening program is unclear. There is widespread agreement that LDCT screening attendance presents a ‘teachable moment’ for cessation advice, especially among those people who receive a positive scan result. Smoking cessation is an area of significant research investment; for instance, eight US-based clinical trials are now underway that aim to address how best to design and deliver cessation programs within large-scale LDCT screening programs.(9) Question 4: What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Assessing the value or cost-effectiveness of LDCT screening involves a complex interplay of factors including data on effectiveness and costs, and institutional context. A key input is data about the effectiveness of potential and current screening programs with respect to case detection, and the likely outcomes of treating those cases sooner (in the presence of LDCT screening) as opposed to later (in the absence of LDCT screening). Evidence about the cost-effectiveness of LDCT screening programs has been summarised in two systematic reviews. We identified a further 13 studies—five modelling studies, one discrete choice experiment and seven articles—that used a variety of methods to assess cost-effectiveness. Three modelling studies indicated LDCT screening was cost-effective in the settings of the US and Europe. Two studies—one from Australia and one from New Zealand—reported LDCT screening would not be cost-effective using NLST-like protocols. We anticipate that, following the full publication of the NELSON trial, cost-effectiveness studies will likely be updated with new data that reduce uncertainty about factors that influence modelling outcomes, including the findings of indeterminate nodules. Gaps in the evidence There is a large and accessible body of evidence as to the effectiveness (Q1) and harms (Q2) of LDCT screening for lung cancer. Nevertheless, there are significant gaps in the evidence about the program components that are required to implement an effective LDCT screening program (Q3). Questions about LDCT screening acceptability and feasibility were not explicitly included in the scope. However, as the evidence is based primarily on US programs and UK pilot studies, the relevance to the local setting requires careful consideration. The Queensland Lung Cancer Screening Study provides feasibility data about clinical aspects of LDCT screening but little about program design. The International Lung Screening Trial is still in the recruitment phase and findings are not yet available for inclusion in this Evidence Check. The Australian Population Based Screening Framework was developed to “inform decision-makers on the key issues to be considered when assessing potential screening programs in Australia”.(10) As the Framework is specific to population-based, rather than high-risk, screening programs, there is a lack of clarity about transferability of criteria. However, the Framework criteria do stipulate that a screening program must be acceptable to “important subgroups such as target participants who are from culturally and linguistically diverse backgrounds, Aboriginal and Torres Strait Islander people, people from disadvantaged groups and people with a disability”.(10) An extensive search of the literature highlighted that there is very little information about the acceptability of LDCT screening to these population groups in Australia. Yet they are part of the high-risk population.(10) There are also considerable gaps in the evidence about the cost-effectiveness of LDCT screening in different settings, including Australia. The evidence base in this area is rapidly evolving and is likely to include new data from the NELSON trial and incorporate data about the costs of targeted- and immuno-therapies as these treatments become more widely available in Australia.