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Articles de revues sur le sujet "Art. 52 c.p"
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Buckner, Jan C., Karla V. Ballman, John C. Michalak, Gary V. Burton, Terrence L. Cascino, Paula J. Schomberg, Roland B. Hawkins et al. « Phase III Trial of Carmustine and Cisplatin Compared With Carmustine Alone and Standard Radiation Therapy or Accelerated Radiation Therapy in Patients With Glioblastoma Multiforme : North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials ». Journal of Clinical Oncology 24, no 24 (20 août 2006) : 3871–79. http://dx.doi.org/10.1200/jco.2005.04.6979.
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Purpose In patients with newly diagnosed glioblastoma multiforme, to determine whether cisplatin plus carmustine (BCNU) administered before and concurrently with radiation therapy (RT) improves survival compared with BCNU and RT and whether survival using accelerated RT (ART) is equivalent to survival using standard RT (SRT). Patients and Methods After surgery, patients were stratified by age, performance score, extent of surgical resection, and histology (glioblastoma v gliosarcoma) and then randomly assigned to arm A (BCNU plus SRT), arm B (BCNU plus ART), arm C (cisplatin plus BCNU plus SRT), or arm D (cisplatin plus BCNU plus ART). Results Four hundred fifty-one patients were randomly assigned, and 401 were eligible. Frequent toxicities included myelosuppression, vomiting, sensory neuropathy, and ototoxicity and were worse with cisplatin. There was no difference in toxicity between SRT and ART. Median survival times and 2-year survival rates for patients who received BCNU plus RT (arms A and B) compared with cisplatin, BCNU, and RT (arms C and D) were 10.1 v 11.5 months, respectively, and 11.5% v 13.7%, respectively (P = .19). Median survival times and 2-year survival rates for patients who received SRT (arms A and C) compared with ART (arms B and D) were 11.2 v 10.5 months, respectively, and 13.8% v 11.4%, respectively (P = .33). Conclusion Cisplatin administered concurrently with BCNU and RT resulted in more toxicity but provided no significant improvement in survival. SRT and ART produced similar toxicity and survival.
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Wu, Hong Lei, Rui Sheng Zheng, Wei Zheng et Zheng Yan. « Growth of p-Type AlN Crystals by C and Si Codoping ». Advanced Materials Research 306-307 (août 2011) : 246–50. http://dx.doi.org/10.4028/www.scientific.net/amr.306-307.246.
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Based on our earlier theoretical investigation,p-type C:Si codoped AlN crystals were grown on SiC substrates by a sublimation method in a improved growth reactor. Hall-effect measurement shows that the AlN crystals have a high hole density of 1.4×1014cm-3and mobility of 52 cm2V-1s-1in spite of the high resistivity (896 Ω•cm). In the AlN samples, Si dopants act as donors due to substituting Al atoms, and most of C dopants act as acceptors for replacing N atoms. It is also observed that the activation energy of C acceptors in C:Si codoped AlN is reduced by codoping Si donors, which agrees with the computational results.
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Farias, Miguel Angel, Silvia Andrea Medici, Aldo Fabián Squassi et Gabriel Antonio Sánchez. « Unmet dental treatment need impairs quality of life in Hepatitis C Virus-infected patients ». STOMATOLOGY EDU JOURNAL 7, no 3 (2020) : 191–96. http://dx.doi.org/10.25241/stomaeduj.2020.7(3).art.5.
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Introduction The hepatitis C virus (HCV) infection is a health condition affecting 3% of the world population, which oral manifestations and associated factors interest both physicians and dentists. The aim of this work was to describe the dental treatment need and the impact of the perception of the oral component of health on the quality of life in HCV+ patients. Methodology Descriptive study on a convenience sample. 45 HCV+ patients (46±5 y.o.) completed the OHIP-14 questionnaire, which consists of 14 questions grouped in 7 domains (D1 functional limitation, D2 physical pain, D3 psychological discomfort, D4 physical disability, D5 psychological disability, D6 social disability and D7 general disability). The participants indicated their responses using a Likert-type frequency scale. The Community Caries Index of Treatment Need (CCITN) was determined for each patient. The proportion and CI95% of the social impact on the quality of life were calculated. The association between CCITN and the quality of life was assessed by Chi2 (p<0.05). Results The CCITN was 11 (8-14). The overall social impact was 38% (24-52%). The increasing order relationship of the impact on each of the domains was D1, D7, D6, D4, D5, D2, D3. A significant association between oral health-related quality of life and CCITN was observed (Chi2 = 7.57, p = 0.006), showing greater impairment of the quality of life as the treatment need increased. Conclusion The association between CCITN and quality of life becomes evident using OHIP-14 during dental appointments. The results suggest the need for comprehensive interventions during the provision of oral health care to HCV+ patients.
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Lebenthal, Brener, Hershkovitz, Shehadeh, Shalitin, Lewis, Elias et al. « A Phase II, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Alpha-1 Antitrypsin (AAT) (Glassia®) in the Treatment of Recent-Onset Type 1 Diabetes ». International Journal of Molecular Sciences 20, no 23 (29 novembre 2019) : 6032. http://dx.doi.org/10.3390/ijms20236032.
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Our aim was to assess the efficacy, safety, and tolerability of alpha-1 antitrypsin (AAT) as a therapeutic modality for β-cell preservation in patients with recent-onset type 1 diabetes. Seventy type 1 diabetes patients (37 males; mean age 13.1 ± 4.1years) were randomized to treatment with 22 infusions of AAT (Glassia®) (60 or 120 mg/kg) or placebo. The primary outcome was the area under the curve (AUC) of C-peptide from a 2-h mixed-meal tolerance test after 52 weeks. At week 52, C-peptide was 0.9, 0.45, and 0.48 pmol/mL in the AAT-120, AAT-60, and placebo groups (p = 0.170 and p = 0.866 vs. placebo, respectively). The declines in C-peptide glycated hemoglobin (HbA1c) and the total insulin dose (U/kg) were similar across groups. Within the predefined 12–18-years subgroup, the C-peptide AUC decreased significantly in the placebo and AAT-60 groups (−0.34 and −0.54 pmol/mL, respectively, p < 0.01), with a borderline decrease in the AAT-120 group (−0.29 pmol/mL, p = 0.047). The mean HbA1c level was significantly lower in the AAT-120 group compared to the placebo (6.7% ± 0.9% vs. 8.2 ± 1.4%, p = 0.05), and a higher percentage of patients attained HbA1c ≤ 7% (75% vs. 25%, p = 0.05). AAT was tolerated well, with a similar safety profile between groups. The AAT intervention showed promise in the subgroup of adolescents with recent-onset type 1 diabetes. Further studies are warranted to determine the impact and proposed mechanism of action of AAT in β-cell preservation.
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Yuen, Man-Fung, Danny Ka-Ho Wong, Erwin Sablon, He-Jun Yuan, Siu-Man Sum, Chee-Kin Hui, Annie On-On Chan, Benjamin Chun-Yu Wong et Ching-Lung Lai. « Hepatitis B Virus Genotypes B and C Do Not Affect the Antiviral Response to Lamivudine ». Antiviral Therapy 8, no 6 (1 août 2002) : 531–34. http://dx.doi.org/10.1177/135965350300800610.
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To date, there have been no studies examining the role of hepatitis B virus (HBV) genotypes on the response to lamivudine therapy and the development of YMDD mutations. The present study aimed at determining any differences in the antiviral response and risk of YMDD mutations between lamivudine-treated patients with HBV genotype B and genotype C. Eighty-two patients receiving lamivudine were recruited. HBV genotypes at baseline and YMDD mutations at week 52 were determined by line probe assays (LiPA). HBV DNA levels were determined by the Cobas Amplicor HBV Monitor Test. Seventeen (20.7%) and sixty-four (78%) patients had single genotypes of B and C, respectively. At both week 24 and 52 there were no differences in the median reduction of HBV DNA levels (median 4 logs drop), the median reduction of alanine aminotransferase (ALT) levels, and the proportion with normalization of ALT [8/8 (100%) vs 26/37 (70.3%), P=0.19] between patients with genotypes B and C. The rate of HBeAg seroconversion [3/17 (17.6%) vs 6/64 (9.4%), P=0.39] and the chance of YMDD mutation development [3/17 (17.6%) vs 12/64 (18.8%), P=1.0] at week 52 were also similar between patients with genotype B and C, respectively. In conclusion, there was no difference in the antiviral response and the rate of development of YMDD mutations in Chinese patients with genotype B and C after 1 year of lamivudine. Determination of HBV genotypes before lamivudine therapy was probably not an important pre-treatment investigation to predict antiviral responses in Chinese patients.
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Karzai, Fatima H., Ravi Amrit Madan, Andrea Borghese Apolo, Yangmin M. Ning, Howard L. Parnes, Philip M. Arlen, Melony A. Beatson et al. « Use of supportive measures to improve outcome and decrease toxicity in docetaxel-based antiangiogenesis combinations in metastatic castrate resistant prostate cancer (mCRPC). » Journal of Clinical Oncology 31, no 15_suppl (20 mai 2013) : e16017-e16017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e16017.
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e16017 Background: We have completed accrual of 63 patients (pts) to our study combining lenalidomide (L), with bevacizumab (B), docetaxel (D), and prednisone (P) (ART-P) in mCRPC. Due to the lack of improved survival and the increased toxicity of anti-angiogenic docetaxel combinations in the MAINSAIL and CALGB 90401 trials, we attempted to compare and contrast our studies with these failed phase III trials. Methods: Among the first 52 pts on ART-P, 3 received L 15 mg daily, 3 received 20 mg daily, and the others received 25 mg daily for 14 days of every 21−day cycle (C). We then enrolled 11 pts at L 15 mg. All pts received D 75 mg/m2 and B 15 mg/kg on day 1 with P 10 mg and enoxaparin daily. Pegfilgrastim was given on day 2. Patients on CALGB 90401 received D 75 mg/m2 and B 15 mg/kg on day 1, with P 10 mg. On MAINSAIL, pts received D 75 mg/m2, L 25 mg daily for 14 days of every 21−day cycle with daily P. Patients on CALGB 90401 and MAINSAIL did not receive enoxaparin or pegfilgrastim prophylactically. Results: The median number of Cs on ART-P is 18 (1-52). Median PFS is 19.1 months. Twenty-seven pts had a PR, and one pt with measurable disease had a CR. Two patients (3%) had deep vein thromboses. Of 1,334 Cs given, 14 cycles were complicated by febrile neutropenia (FN) (1%). There were no treatment related deaths. In comparison, median number of Cs in MAINSAIL L+DP arm was 6, with a PFS of 45 weeks and an OS of 77 weeks. Thirty-four pts (6.5%) developed pulmonary emboli and there were 2 deaths due to toxicity in the experimental arm. Nearly 12% of Cs were complicated by FN. In the experimental arm of CALGB 90401 trial, median OS was 22.6 months with median PFS of 9.9 months. The median number of Cs were 8 and 19 pts developed thrombosis/emboli (3.6%). In addition, 37 patients developed FN and treatment related deaths were reported at 4%. Conclusions: The use of supportive care allowed longer treatment duration with the ART-P combination as compared to D+L (MAINSAIL) and D+B (CALGB 90401), potentiating a longer PFS, RR and possibly OS with an improved safety profile. This data demonstrates the potential importance of supportive measures and is hypothesis generating for future combination studies. Clinical trial information: NCT00942578.
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Karzai, Fatima H., Bamidele Adesunloye, Yangmin M. Ning, Ravi Amrit Madan, James L. Gulley, Andrea Borghese Apolo, Melony A. Beatson et al. « Use of supportive measures to improve outcome and decrease toxicity in docetaxel-based antiangiogenesis combinations. » Journal of Clinical Oncology 31, no 6_suppl (20 février 2013) : 128. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.128.
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128 Background: We have recently completed accrual of 63 patients (pts) to our study combining lenalidomide (L), with bevacizumab (B), docetaxel (D), and prednisone (P) (ART-P). Due to the lack of improved survival and the increased toxicity of anti-angiogenic docetaxel combinations in the MAINSAIL and CALGB 90410 trials we attempted to contrast and compare our studies with the failed phase III trials. Methods: Among the first 52 pts on the ART-P, 3 received L 15 mg daily, 3 had 20 mg daily, and the rest had 25 mg daily for 14 days of every 21−day cycle (C). We later enrolled 11 more pts at L 15 mg. All pts received D 75 mg/m2 and B 15 mg/kg on day 1 with P 10 mg and enoxaparin daily throughout each C. Pegfilgrastim was given on day 2. Patients on CALGB 90410 received D 75 mg/m2 and B 15 mg/kg on day 1 with P 10 mg and on MAINSAIL received D 75 mg/m2, L 25 mg daily for 14 days of every 21−day cycle with daily P. Patients on CALGB 90410 and MAINSAIL did not receive enoxaparin or pegfilgrastim prophylactically. Results: Median number of Cs in ART-P was 16 (3−38). PFS was 22 months and median OS has not been reached. Pts with measurable disease had 1 CR and 25 PR (86.7% RR). Two patients (3%) had deep vein thromboses. Of 1,219 cycles given, 14 cycles were complicated by febrile neutropenia (FN) (1.1%). There were no treatment related deaths. In comparison, median number of Cs in MAINSAIL L+DP arm was 6, with a PFS of 45 weeks and an OS of 77 weeks. Thirty-four pts (6.5%) developed pulmonary emboli and there were 2 deaths due to toxicity in the experimental arm. Nearly 12% of Cs were complicated by FN. In the experimental arm of CALGB 90410 trial, median OS was 22.6 months with median PFS of 9.9 months. Median number of Cs was 8, and 19 pts developed thromboses/emboli (3.6%). In addition, 7% of patients developed FN and treatment related deaths were reported at 4%. Conclusions: The use of supportive care allows the ART-P combination to be given for more cycles than were given in MAINSAIL and CALGB 90401 potentiating a longer PFS, RR and possibly OS with an improved toxicity profile. This data demonstrates the potential importance of supportive measures and is hypothesis generating for future combination studies. Clinical trial information: NCT00942578.
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Saito, Hidehiko, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Ryuzo Ohno, Akio Hirayama et al. « Efficacy and Safety of Recombinant Human Soluble Thrombomodulin (ART-123) in Disseminated Intravascular Coagulation (DIC) : Results of Phase III Randomized, Double-Blind, Clinical Trial. » Blood 108, no 11 (16 novembre 2006) : 576. http://dx.doi.org/10.1182/blood.v108.11.576.576.
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Abstract Background: Thrombomodulin is a thrombin receptor on the endothelial cell surface that plays an important role in the regulation of intravascular coagulation. Recombinant human soluble thrombomodulin (ART-123) is composed of the active, extracellular domain of thrombomodulin. ART-123 has been shown to have a wider safety margin than other anticoagulants and to have a favorable antithrombotic profile with less bleeding in animal and in vitro experiments. ART-123 is a promising therapeutic natural anticoagulant that is comparable to antithrombin, tissue factor pathway inhibitor and activated protein C. Objective: We conducted a multicenter, double-blind, randomized parallel-group trial to compare the efficacy and safety of ART-123 to those of heparin for the treatment of disseminated intravascular coagulation (DIC) associated with infection or hematologic malignancy. Methods: DIC was diagnosed according to the diagnostic criteria established by the Japanese Ministry of Health and Welfare. DIC patients were assigned to receive ART-123 (0.06 mg/kg for 30 min, once a day) or heparin sodium (8 units/kg/h for 24 h) for six days using a double dummy method. The primary efficacy endpoint was DIC resolution rate (rate of recovery from DIC). The secondary endpoints included clinical course of bleeding symptoms, and mortality at 28 days. Results: 234 DIC patients were randomized (117 in each arm). DIC resolution rate was 66.1% for the ART-123 group and 49.9% for the heparin group (difference 16.2%; 95% CI 3.3–29.1), thus demonstrating that ART-123 is significantly superior to heparin for the improvement of DIC. Patients in the ART-123 group also showed more marked improvement in clinical course of bleeding symptoms (p=0.0271) and the disappearance rate of bleeding symptoms in the ART-123 group was higher than that in the heparin group (35.2% vs 20.9%; difference 14.3%). The incidence of bleeding-related adverse events up to 7 days after the start of administration was lower in the ART-123 group than in the heparin group (43.1% vs 56.5%; difference; −13.4%; p=0.0487). The mortality rate at 28 days in the ART-123 group was 22.0% vs 25.5% in the heparin group (difference −3.4%; p=0.5396). Although no significant differences were seen, 28-day mortality for the ART-123 group was slightly lower. The mortality rate of patients with DIC secondary to infection in the ART-123 and heparin groups was 28.0% (14/50) and 34.6% (18/52), respectively, indicating a 6.6% lower mortality in the ART-123 group. Conclusion: When compared with low-dose heparin, ART-123 more significantly improves DIC and alleviates bleeding symptoms in DIC patients. The incidence of bleeding-related adverse events is significantly lower with ART-123 than with heparin. Because of its safety and efficacy, ART-123 appears to be a first-line agent in the management of DIC.
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Kharlamova, T. V., S. L. Voznesenskiy, T. N. Ermak, G. M. Kozhevnikova et P. V. Klimkova. « Infectious endocarditis in HIV-infected intensive care unit patients ». Journal Infectology 14, no 2 (13 juillet 2022) : 73–79. http://dx.doi.org/10.22625/2072-6732-2022-14-2-73-79.
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Infective endocarditis (IE) is one of the most common cardiac complications in HIV patients who are intravenous drug addicts. The presence of IE and secondary diseases in immunocompromised individuals usually requires specific diagnostic and therapeutic approach.Aim: Optimizing the diagnosis of IE in patients with advanced HIV/AIDS.Materials and methods We reviewed 429 case records of HIV/AIDS ICU patients using the modified duke criteria for diagnosis of infective endocarditis. Statistical significance (p <0.05) of data was assessed using the χ2 test.Results. 25 patients were diagnosed with IE. The male gender dominated – 68%. Mean age was 38. 60% had stage 4B HIV infection. 68% were ART naive. The medium viral load was 294560 copies / ml, while the medium CD4 count was 218 cells / μl. Fever of >38°C was a key symptom found in all patients. Blood cultures were positive in 60% cases. 80% had a high C reactive protein (CRP), and 44% had CRP levels above 100 mg/l. Procalcitonin (PCT) levels were increased in 52%. Echocardiogram revealed IE in 92%. Pneumonia was diagnosed in 92%. Fatal outcome occurred in 76%. Anemia was a predictor of severe outcome (p<0.002), while patients with leukocytosis had good prognosis (p<0.05).Conclusion. Infective endocarditis is a common complication among HIV IDUs. The most common diagnostic criteria are fever >38°C, pneumonia, anemia, leukocytosis, thrombocytopenia and echocardiographic findings. The levels of the hemoglobin and WBCs could evaluate prognosis of the disease outcome.
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Yastrebova, E. B., O. E. Chernova, A. M. Kalyshenko et G. A. Vertogradova. « Chronic hepatitis C in children with HIV infection : disease phenotype and efficacy of antiviral therapy ». Infekcionnye bolezni 19, no 2 (2021) : 52–58. http://dx.doi.org/10.20953/1729-9225-2021-2-52-58.
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Objective. To analyze the course of chronic hepatitis C (CHC) and efficacy of its treatment in children with HIV infection. Patients and methods. This study included 29 children aged 12 to 17 years (mean age 15.1 ± 0.2 years) with perinatal HIV infection and CHC. HIV stages were distributed as follows: stage 4A in 24 individuals (82.8%), stage 4B in 4 individuals (13.8%), and stage 4B in 1 individual (3.4%). All 29 patients received antiretroviral therapy. The distribution of children by HCV genotypes was as follows: 1a in one child (3.4%), 1b in 12 children (41.4%), and 3a in 16 children (55.2%). Antiviral therapy for CHC included glecaprevir/pibrentasvir (3 tablets; 100 mg + 40 mg) once a day for 56 days. Data analysis was performed using the Statistica for Windows software (version 10.0). Results. The mean HCV RNA level was 595,666 ± 34,734 IU/mL (range: 1,100–3,863,025 IU/mL). After 4, 8, or 12 weeks of antiviral therapy for HCV, HCV RNA clearance was achieved in all study participants (p = 0.01). Before treatment initiation, mean CD4+ count was 738 ± 34 cells/μL (above 500 cells/μL), which indicated the absence of immunodeficiency in the group analyzed. Successful antiviral therapy for HCV (sustained virologic response at week 12; SVR 12) also resulted in increase of the CD4+ lymphocytes level, which was considered as a positive effect of glecaprevir/pibrentasvir (p = 0.15). We observed significant differences in the level of liver enzymes (ALT and AST) (p = 0.01) between samples collected before antiviral therapy initiation and those collected during treatment, as well as 12 weeks after its completion (SVR12). All children demonstrated good tolerance of glecaprevir/pibrentasvir; none of them had adverse events, complaints, or clinical/laboratory changes. Conclusion. Thus, all children with HIV infection and CHC achieved SVR12 after the 8-week course of antiviral therapy with glecaprevir/pibrentasvir regardless of HCV genotype. Clinical manifestations (hepatosplenomegaly in 62.1%; asthenovegetative syndrome in 31.0%) were eliminated after 8 weeks of therapy. Laboratory manifestations (hepatic cytolysis (AST/ALT)) were normalized after 4 weeks of therapy. Antiviral treatment for HCV resulted in some increase in the level of CD4+ lymphocytes. We observed no adverse events caused by glecaprevir/pibrentasvir (neither clinical symptoms nor changes in complete blood count or liver function tests), which confirms the safety of this treatment regimen. Key words: antiretroviral therapy, HIV infection, children, direct-acting antivirals, chronic hepatitis C
Thèses sur le sujet "Art. 52 c.p"
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ROSSI, LUCREZIA SILVANA. « LA LEGITTIMA DIFESA NEL DOMICILIO (ART. 52 C. 2-4 C.P.) UN¿INDAGINE TRA STORIA, COMPARAZIONE, TEORIA E PRASSI ». Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/852006.
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L’elaborato tratta il delicato tema della legittima difesa esercitata nel domicilio, che è stato oggetto di due riforme negli ultimi quindici anni – prima nel 2006, poi nel 2019 –, suscitando diffuse critiche e contrastanti pareri in ordine alla sua esatta portata.
La grande attenzione pubblica per l’istituto e i due interventi legislativi hanno stimolato l’interesse e il desiderio di approfondire l’origine, la ratio e l’evoluzione della scriminante di cui all’art. 52 c.p. Lo scopo della presente indagine è duplice: da una parte, si è cercato di comprendere le esigenze sottostanti alle riforme e, più in generale, il fondamento del bisogno così ben radicato nella società contemporanea di una differenziazione di trattamento per le aggressioni perpetrate all’interno dell’abitazione; dall’altra, invece, partendo dallo studio della disciplina attualmente in vigore e dell’applicazione concreta della medesima ad opera della giurisprudenza, si è provato a trovare un equilibrio più soddisfacente tra le esigenze diffuse e il rispetto della Carta costituzionale e della Convenzione europea dei diritti dell’uomo, in sintesi una “contro-riforma sostenibile”.
La tesi si articola in tre parti, di cui la prima è dedicata all’analisi storico-comparatistica della causa di giustificazione. In particolare, lo studio ripercorre le origini dell’istituto a partire dal diritto romano sino ai giorni nostri, cercando di evidenziare i precedenti storici atti a spiegare l’attuale predisposizione di una figura speciale di legittima difesa a beneficio di colui che sia aggredito in luoghi privati in ordine ai quali vanti uno ius excludendi alios nei confronti dell’aggressore. La ricerca storica è affiancata da un’indagine comparatistica, anch’essa impostata in prospettiva storica, che allarga lo sguardo alle scelte compiute in argomento dai principali ordinamenti europei – segnatamente quello francese e inglese –, nonché dal sistema federale statunitense.
La seconda parte della tesi ha ad oggetto il diritto interno vigente; in particolare l’elaborato affronta prima la legge n. 59 del 13 febbraio 2006 e poi la legge n. 36 del 26 aprile 2019, ossia le riforme che hanno conferito rilievo alla figura speciale della legittima difesa domiciliare. A tal fine, si considera tanto il contesto politico criminale che ne ha segnato l’origine, quanto il contenuto delle riforme alla luce della giurisprudenza di legittimità; è stato infatti svolto uno studio su tutte le pronunce emesse dalla Corte di Cassazione in materia di legittima difesa domiciliare dal 1° gennaio 2000 sino al 1° gennaio 2021. Grazie a tale ricerca è emerso da una parte come la prima riforma risulti sostanzialmente priva di ricadute concrete e, dall’altra, come il secondo intervento legislativo, ove non sottoposto a un’interpretazione correttiva alla luce delle direttrici costituzionali e convenzionali europee, sia pericoloso per la tenuta del sistema. Lungo tale direttrice, l’indagine si sofferma in particolare sul ruolo che dovrebbero assumere il requisito della necessità e le presunzioni normative di legittimità della reazione. Con riferimento al caso dell’eccesso, poi, si prospettano i criteri rilevatori del grave turbamento e delle condizioni di minorata difesa a cui si ricollegano effetti scusanti.
La terza ed ultima parte dell’elaborato, infine, tratta l’istituto in una prospettiva de iure condendo; nello specifico, prendendo le mosse dai risultati raggiunti attraverso l’indagine realizzata, si è provato ad avanzare una proposta di risistemazione della causa di giustificazione che si articola in tre passaggi, idealmente collegati tra loro. Secondo tale ipotesi di lavoro, l’art. 52 c.p. guadagnerebbe in razionalità ed efficacia se, anzitutto, fossero eliminati i commi disciplinanti la legittima difesa domiciliare attualmente in vigore; inoltre, alla disposizione di cui al c. 1 dell’art. 52 c.p. dovrebbe affiancarsi una scusante legata allo stato di turbamento emotivo vissuto dall’aggredito, applicabile alla fattispecie generale per i casi di eccesso e di errore sulla legittima difesa; infine, si potrebbe prevedere una presunzione iuris tantum di pericolo attuale per la sola incolumità dei presenti in caso di aggressione perpetrata all’interno del domicilio e dell’esercizio commerciale.
La compresenza di tali proposte modificative sembrerebbe in grado di conferire un rinnovato equilibrio alla causa di giustificazione, da una parte dando voce e riconoscimento alle istanze diffuse, dall’altra rispettando i principi e i valori di cui la Costituzione e la Convezione europea dei diritti dell’uomo sono espressione, dall’altra ancora imprimendo una spinta contraria rispetto all’attuale tendenza antistatalista, se non addirittura anticostituzionale, di cui le due recenti riforme in materia si sono rese portavoce.The thesis deals with the delicate issue of self defence exercised in the home, which has been the subject of two reforms in the last fifteen years – first in 2006, then in 2019 –, arousing widespread criticism and conflicting opinions regarding its exact scope. The great public attention for the institute and the two legislative interventions have stimulated the interest and the desire to investigate the origin, the ratio and the evolution of the justification regulated by art. 52 c.p. The purpose of this survey is twofold: on the one hand, an attempt has been made to understand the needs underlying the reforms and, more generally, the foundation of the need so well rooted in contemporary society for a differentiation of treatment for attacks perpetrated inside the house; on the other hand, starting from the study of the discipline currently in force and the concrete application of the same by jurisprudence, an attempt has been made to find a more satisfactory balance between the widespread needs and compliance with the Constitutional Charter and the European Convention of human rights, in short a "sustainable counter-reform". The thesis is divided into three parts, of which the first is dedicated to the historical-comparative analysis of the justification. In particular, the study traces the origins of the institute starting from Roman law up to the present day, trying to highlight the historical precedents capable of explaining the current predisposition of a special figure of self defence in favour of anyone who is attacked in private places, where individuals boasts an ius excludendi alios against the aggressor. The historical research is accompanied by a comparative survey, also set in a historical perspective, which broadens the gaze to the choices made on the subject by the main European systems – notably the French and English ones –, as well as by the US federal system. The second part of the thesis concerns the internal law in force; in particular, the paper first deals with law no. 59 of 13 February 2006 and then the law n. 36 of 26 April 2019, i.e. the reforms that have given prominence to the special figure of home self defence. To this end, both the criminal political context that marked its origin and the content of the reforms in the light of the jurisprudence of legitimacy are considered; in fact, a study was carried out on all the rulings issued by the Court of Cassation regarding home self defence from 1 January 2000 until 1 January 2021. Thanks to this research, it emerged on the one hand how the first reform is substantially devoid of concrete repercussions and, on the other hand, how the second legislative intervention, if not subjected to a corrective interpretation in the light of constitutional and conventional guidelines, is dangerous for system tightness. Along this line, the investigation focuses in particular on the role that the requirement of necessity and the normative presumptions of legitimacy of the reaction should assume. With reference to the case of excess, then, are presented the criteria for detecting the serious disturbance and the conditions of impaired defence to which excuse effects are linked. Finally, the third and last part of the paper deals with the institution from a de iure condendo perspective; specifically, starting from the results achieved through the survey carried out, an attempt was made to put forward a proposal for reorganization of the justification which is divided into three steps, ideally connected to each other. According to this working hypothesis, art. 52 c.p. would gain rationality and effectiveness if, first of all, the paragraphs governing home self defence currently in force were eliminated; furthermore, beside the provision referred to art. 52 c. 1 c.p., there should be an excuse linked to the state of emotional disturbance experienced by the attacked, applicable in cases of excess and error in self defence; finally, an iuris tantum presumption of current danger could be envisaged for the sole safety of those present in the event of aggression perpetrated within the home and business. The coexistence of these amending proposals would seem capable of giving a renewed balance to the justification, first of all giving voice and recognition to the widespread requests, furthermore respecting the principles and values of which the Constitution and the European Convention of human rights are an expression, and lastly still giving a push contrary to the current anti-statist tendency, if not even anti-constitutional, of which the two recent reforms on the subject have become spokesmen.
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Oliveira, Rejane Nunes Lopes de. « Tratamento restaurador atraum?tico (ART) : avalia??o de um protocolo de atendimento em gestantes da rede p?blica do munic?pio de Feira de Santana ». UNIVERSIDADE ESTADUAL DE FEIRA DE SANTANA, 2007. http://localhost:8080/tede/handle/tede/40.
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Previous issue date: 2007-12-18The Atraumatic Restorative Treatment (ART) is a treatment alternative for the caries disease, which remains with high prevalence, and constitutes a serious public health problem. The ART consists in the removal of the carious tissue with manual instruments and later closing of its cavities with glass-ionomer cement (GIC). It is important to develop a health promotion program associated with the clinical procedure. The World Health Organization (WHO) recommends the utilization of such technique for several groups, including pregnant women. The aim of this clinical essay was to check the use of the Atraumatic Restorative Treatment in pregnant women of the public system in Feira de Santana Bahia. The sample consisted of 35 pregnant women who underwent 84 class-I restorations and 71 dental sealants with GIC Ketac Molar EasyMix. After anamnesis and clinical examinations, a semi-structured form was filled out on oral hygiene and dietary practices, and on the extent of the technical acceptance. This group was inserted into a health promotion program with speeches, supervised brushings and plaque rate collection. An examiner carried out clinical evaluation of the restorations and of the sealants after a six-month period, through standard scores (0-9) which were later turned into success (0, 1 and 7) and unsuccess (2, 3, 4, 5, 6 and 8). It has been used the successful criterion for the sealants (present or partial loss) and the unsuccessful one (total loss). After the systematization of the collected data, it was observed success in 90,5% for ART and 85,9% for sealants. With regard to the program, 71,4% pregnant women reported changes in oral hygiene and 54,3% in dietary habits. A significant difference occurred between the initial and final averages of the plaque rates, being such reduction, on average, 17,71%. The extent of technical acceptance was 100%. It has been concluded that ART is feasible as a tooth decay treatment alternative in pregnant women inserted in a preventive educational program. It has been inferred that more researches have to be carried out, promoting the development of public policies which increase the use of ART in pregnant women.
A c?rie dent?ria constitui-se em um grave problema de sa?de p?blica, com alta preval?ncia em diversas popula??es. O Tratamento Restaurador Atraum?tico (ART) ? uma alternativa de interven??o para esta patologia, consiste na remo??o do tecido cariado com instrumentos manuais e posterior fechamento das cavidades com cimento de ion?mero de vidro (CIV). Aliado ao procedimento cl?nico, ? importante se desenvolver um programa de promo??o de sa?de. A Organiza??o Mundial de Sa?de (OMS) recomenda a utiliza??o do ART para diversos grupos, entre eles, as gestantes. Este ensaio cl?nico teve como objetivo avaliar um protocolo de Tratamento Restaurador Atraum?tico em gestantes da rede p?blica de Feira de Santana - BA. A amostra consistiu de 35 gestantes, nas quais foram realizados 84 restaura??es e 71 selantes com CIV Ketac Molar Easymix. Ap?s anamnese e exame cl?nico, foi aplicado um formul?rio semi-estruturado sobre as pr?ticas de higiene bucal e dieta, e sobre o grau de aceita??o da t?cnica. Esse grupo foi inserido em um programa educativo-preventivo de sa?de, com palestras, escova??o supervisionada e coleta de ?ndice de placa. Ap?s seis meses, a avalia??o cl?nica das restaura??es e dos selantes foi realizada por um examinador. As restaura??es foram analisadas pelos escores padronizados (0-9) que posteriormente foram transformados em sucesso (0, 1 e 7) e insucesso (2, 3, 4, 5, 6 e 8). Para os selantes utilizou-se o crit?rio sucesso (presente ou perda parcial) e insucesso (perda total). Ap?s a sistematiza??o dos dados coletados observou-se sucesso de 90,5% para ART e 85,9% para selantes. Em rela??o ao programa, 71,4% das gestantes referiu mudan?as de h?bitos na higiene bucal e 54,3% mudaram h?bitos na dieta. Ocorreu uma diferen?a significativa entre as m?dias dos ?ndices de placa inicial e final, sendo essa redu??o em m?dia de 17,71%. O grau de aceita??o da t?cnica foi de 100%. Concluiu-se que o ART ? uma alternativa de tratamento vi?vel para c?rie em gestantes, inseridas em um programa educativo preventivo. Este estudo aponta para a necessidade de mais pesquisas que fomentem o desenvolvimento de pol?ticas p?blicas e ampliem a utiliza??o do ART em gestantes.
Livres sur le sujet "Art. 52 c.p"
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Rodríguez, Joshua Merchán. C. T. P. : Compañía de Trueque Polimérico. Ciudad de México : PotentA Ediciones, 2021.
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D, Bartlett Louisa, et Sewell C. Biggs Museum of American Art., dir. Delaware silver : The Col. Kenneth P. and Regina I. Brown collection. Dover, DE : Biggs Museum of American Art, 2008.
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Prieto, Eduardo Ortega. La extinción de la relación laboral por amortización del puesto de trabajo : Comentarios de urgencia al Art. 52.c del Estatuto de los Trabajadores. Barcelona : Editorial Praxis, 1995.
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(Firm), Drouot-Richelieu. Tableaux modernes : P. Aizpiri, A. Barbier, E.C. Benezit, E. Bourdin, M. Boulet, Y. Brayer, G. Cambier, Carlos-Reymond, J. Carzou, P. Charavel, V. Charreton, H.C. Delpy, A. Dignimont, J. Dunoyer, A. Dunoyer de Segonzac, G. d'Espagnat, S. Ferat, L. Fini, Frank-Boggs, L. Genin, M. Girard, N. Giuffrida, H. Goetz, A. Guillaumin, A. Hambourg, N. Henon, C. Hilaire, J.B. Jongkind, M. Journod, L. Laborit, P. Laprade, P. Laroche, M. Laurencin, E. de La Villeon, H. Lebasque, A. Lhote, J. Le Guennec, M. Luce, D. Lucas, E. Maclet, H. Manguin, A. Marquet, M. Martin, Mayeux, Meg, P.E. Montezin, J.P. Pascin, R. Quence, L. Touchagues, J.B. Valadie, L. Valtat, Vander Hacehenn, M. de Vlaminck, C. Wauthier, F. Witte, F. Ziem ; tableaux du XIXe siècle ; bijoux ; argenterie ; verrerie "art nouveau" et modernes ; Extrême-Orient, paravants, vases, pagode en serpentine, statuette en jade ; sculptures ; meubles et objets d'art, commode transition par E. Avril, pair de fauteuils par I. Nadal, bibliothèque par P. Defriche, Bureau par P. Sormani, tapis. Paris : Drouot-Richelieu, 2001.
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(Firm), Drouot-Richelieu. Gravures XVIIIe et XIXe siècles ... dessins, tableaux modernes XIXe et XXe siècles ... dessins, tableaux anciens XVIIe et XVIIIe siècles ... curiosités ... éperonnerie, étriers et mors ... objets d'art et d'ameublement ... art nouveau ... beau mobilier d'époque et de style ... bel ensemble de meubles néo renaissance ... tapis, tapisserie : G. Volpato, G.B. Piranesi, F. Goya, P.C. Helleu, J. Benoit-Levy, Y. Brayer, R. Cat, C. Cottet, E. Galien-Laloue, Gen Paul, C. Guys, H. Harpignies, J. Girardet, R. His, E. de la Villeon, A. Lebourg, P.E. Montezin, C. Pissaro, Th. Clément, L. Icart, F. Mortelmans, A. Veron, C.N. Cochin, H. Robert, A. Romany, nombreux portraits de l'École française XVIIIe, N.D. Bouget, G.P. Verbruggen II Le Jeune, J.P. George-Juillard ; bel enxemble de couteaux provenant de la collection Léon Lindet ; bronzes de Barys, pendules, cartel d'applique écaille, vases de E. Gallé, mobilier de salle à manger de Majorelle (expo. Paris 1904) ; belle commode de P. Roussel, paire d'encoignures de J. Holthausen, important tapis d'Aubusson XIXe siècle, tapisserie de Lille d'après Téniers. Paris : Néret-Minet, 2002.
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Farrell, K. Art and Nature X6 C/P. Little, Brown Book Group Limited, 1992.
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Kravchuk, Michael. C. P. e Bach Solfeggietto : Practice Guide. Independently Published, 2020.
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Barredo, Maria, Caleb Fernandez, Seth Fernandez, Eliott Garcia et Robert Cruz. Art of Story : P. A. C. E. 2018-19. Independently Published, 2019.
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Harold, Wayne Alan, et P. Craig Russell. P Craig Russell Selfish & Other Stories Fine Art Hc (C : 0-1-. Wayne Alan Harold Productions, 2019.
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Perkins, Robin, et Clifford Selbert. S. P. A. C. E. : Selbert Perkins Art, Communications and Environments (Space). Visual Reference Publications, 2006.
Trouver le texte intégralChapitres de livres sur le sujet "Art. 52 c.p"
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Golding, Rosemary. « C. Hubert H. Parry, ‘Preliminaries’ in The Art of Music ». Dans Music in Nineteenth-Century Britain, 476–85. London : Routledge, 2022. http://dx.doi.org/10.4324/9781003003908-52.
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Feldhoff, Tobias, et Falk Radisch. « Why Must Everything Be So Complicated ? Demands and Challenges on Methods for Analyzing School Improvement Processes ». Dans Accountability and Educational Improvement, 9–25. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69345-9_2.
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AbstractIn the recent years, awareness has risen by an increasing number of researchers that we need studies that appropriately model the complexity of school improvement if we want to increase our knowledge about school improvement substantially and to close the identified research gaps within this field (Feldhoff T, Radisch F, Klieme E, J Educ Admin 52(5):565–736, 2014; Hallinger P, Heck RH, School Effect School Improv 22(2):149–173, 2011; Sammons P, Davis S, Day C, Gu Q, J Educ Admin 52(5):565–589, 2014). So far, respective quantitative studies, that appropriately consider those complexities, have hardly been realized because of the high efforts of current methods and costs involved (Feldhoff T, Radisch F, Bischof LM, J Educ Admin 2(54):209–240, 2016). It is, therefore, apparent to look for new, innovative methods that can adequately take into account the complexity of school improvement. For a reasonable search and selection of innovative methods, it is necessary to describe the systematic complexity of school improvement and the resulting requirements for the methods in more detail. This is a central goal in this chapter. For this reason, we present our framework of complexity. We then formulate questions that will prompt the reader to reflect critically upon the methods in general and especially in this volume.
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Desille, Amandine, et Karolina Nikielska-Sekula. « Introduction ». Dans IMISCOE Research Series, 1–27. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67608-7_1.
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AbstractA significant effort in theorising and conceptualising the visual has been made within various disciplines. To mention only a few, Howard Becker (Art as collective action. Am Sociol Rev 767–776, 1974) in visual sociology, Lucien Taylor (Visualising theory. Routledge, 1994), Marcus Banks and Howard Morphy ((eds): Rethinking visual anthropology. Yale University Press, London, 1999) and Jay Ruby (Picturing culture: explorations of film and anthropology. University of Chicago Press, Chicago, 2000) in visual anthropology, Chris Jenk ((ed): Visual culture. Routledge, 1995) in cultural studies, Gillian Rose (Visual methodologies: an introduction to the interpretation of visual methods. Sage, 2001) in geography and Sarah Pink (Doing visual ethnography. Sage, London, 2001) in visual ethnography, all produced fundamental works focusing on the visual in social sciences. This book, however, without diminishing the disciplinary work within the subject, proposes to approach visual methodologies in the specific context of a field of study, adopting an interdisciplinary approach that brings together geography, sociology, anthropology and communication studies. As Adrian Favell (Rebooting migration theory: interdisciplinarity, globality and postdisciplinarity in migration studies. In: Brettell C, Hollifield J (eds) Migration theory: talking across disciplines. Routledge, pp 259–278, 2007, p. 1988) has suggested: “On the face of it, there could hardly be a topic in the contemporary social sciences more naturally ripe for interdisciplinary thinking than migration studies.” In this piece we will attempt to explain why the adoption of visual methodologies in the field of migration studies is of particular interest.
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« ΣΤΟΥ ΚΑΦΕΝΕΙΟΥ ΤΗΝ ΕΙΣΟΔΟ ». Dans C. P. Cavafy, 102–3. Princeton University Press, 2022. http://dx.doi.org/10.2307/j.ctv25wxchr.52.
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Taber, Douglass F. « Development of Flow Reactions ». Dans Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0015.
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For a review of a monograph by C. Wiles and P. Watts on applications of flow reactors in organic synthesis, see Org. Process. Res. Dev. 2011, 15, 947. For a review by Klavs S. Jensen of MIT of flow approaches, see Angew. Chem. Int. Ed. 2011, 50, 7502. Hans-René Bjørsvik of the University of Bergen described (Org. Process. Res. Dev. 2011, 15, 997) a multijet oscillating disc microreactor, and Andreas Schmid of the Technische Universität Dortmund (Adv. Synth. Catal. 2011, 353, 2511) and László Poppe of the Budapest University of Technology and Economics discussed (Adv. Synth. Catal. 2011, 353, 2481) continuous flow reactors for biotransformations. Gases are readily handled in a flow apparatus. S. Chandrasekhar of the Indian Institute of Chemical Technology, Hyderabad demonstrated (Tetrahedron Lett. 2011, 52, 3865) partial deuteration of 1 to 2, using D2O as the deuterium source. Peter H. Seeberger of the Max Planck Institute, Potsdam oxidized (Org. Lett. 2011, 13, 5008) 3 to 4 with singlet oxygen. Dong-Pyo Kim of Chungnam National University and Robert H. Grubbs of Caltech effected (Org. Lett. 2011, 13, 2398) ethenolysis of 5 to give 6 and 7. Takashi Takahashi of the Tokyo Institute of Technology showed (Chem. Commun. 2011, 47, 12661) that even phosgene could be handled in a flow system, using it to activate 8 for condensation with benzylamine to give 9. In the liquid phase, Stephen L. Buchwald of MIT prepared (Angew. Chem. Int. Ed. 2011, 50, 8900) 11 by the fluorination of 10. Jesús Alcázar of Janssen Pharmaceutical, Toledo, showed (Tetrahedron Lett. 2011, 52, 6058) that a nitrile 12 could be reduced in a flow system to the aldehyde 13. Mark York of CSIRO prepared (Tetrahedron Lett. 2011, 52, 6267) the furan 16 by condensation of 14 with 15. Floris P.J.T. Rutjes of Radboud University Nijmegen used (Org. Process Res. Dev. 2011, 15, 783) the careful controls of a flow reactor to optimize the exothermic combination of 17 with 18 to give 19. Professor Buchwald demonstrated (Angew. Chem. Int. Ed. 2011, 50, 10665) a flow protocol for the lithiation of 20 with in situ borylation and Pd-catalyzed coupling with 21 to give 22.
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Taber, Douglass F. « Reactions of Alkenes : The RajanBabu Synthesis of Pseudopterosin G-J Aglycone Dimethyl Ether ». Dans Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0029.
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Xiangge Zhou of Sichuan University showed (Tetrahedron Lett. 2011, 52, 318) that even the monosubstituted alkene 1 was smoothly converted to the methyl ether 2 by catalytic FeCl3. Brian C. Goess of Furman University protected (J. Org. Chem. 2011, 76, 4132) the more reactive alkene of 3 as the 9-BBN adduct, allowing selective reduction of the less reactive alkene to give, after reoxidation, the monoreduced 4. Nobukazu Taniguchi of the Fukushima Medical University added (Synlett 2011, 1308) Na p-toluenesulfinate oxidatively to 1 to give the sulfone 5. Krishnacharya G. Akamanchi of the Indian Institute of Chemical Technology, Mumbai oxidized (Synlett 2011, 81) 1 directly to the bromo ketone 6. Osmium is used catalytically both to effect dihydroxylation, to prepare 8, and to mediate oxidative cleavage, as in the conversion of 7 to the dialdehyde 9. Ken-ichi Fujita of AIST Tsukuba devised (Tetrahedron Lett. 2011, 52, 3137) magnetically retrievable osmium nanoparticles that can be reused repeatedly for the dihydroxylation. B. Moon Kim of Seoul National University established (Tetrahedron Lett. 2011, 52, 1363) an extraction scheme that allowed the catalytic Os to be reused repeatedly for the oxidative cleavage. Maurizio Taddei of the Università di Siena showed (Synlett 2011, 199) that aqueous formaldehyde could be used in place of Co/H2 (syngas) for the formylation of 1 to 10. Hirohisa Ohmiya and Masaya Sawamura of Hokkaido University prepared (Org. Lett. 2011, 13, 1086) carboxylic acids (not illustrated) from alkenes using CO2. Joseph M. Ready of the University of Texas Southwestern Medical Center selectively arylated (Angew. Chem. Int. Ed. 2011, 50, 2111) the homoallylic alcohol 11 to give 12. Many reactions of alkenes are initiated by hydroboration, then conversion of the resulting alkyl borane. Hiroyuki Kusama of the Tokyo Institute of Technology photolyzed (J. Am. Chem. Soc. 2011, 133, 3716) 14 with 13 to give the ketone 15. William G. Ogilvie of the University of Ottawa added (Synlett 2011, 1113) the 9-BBN adduct from 1 to 16 to give 17. Professors Ohmiya and Sawamura effected (Org. Lett. 2011, 13, 482) a similar conjugate addition, not illustrated, of 9-BBN adducts to α,β-unsaturated acyl imidazoles.
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Bailey, Matthew P., et Joan T. Hallett. « Ice Crystals in Cirrus ». Dans Cirrus. Oxford University Press, 2002. http://dx.doi.org/10.1093/oso/9780195130720.003.0007.
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Cirrus is conventionally considered as cloud forming in the Earth's upper troposphere at temperatures somewhat below -40°C, composed of ice crystals and forming long, wispy trails. This characteristic shape, in the form of a curl of hair, results from evaporation in vertical shear of horizontal winds, and leads to its Latin name—originally proposed by Luke Howard in 1803. Here we address the nucleation, growth, and evaporation processes that influence the concentration and shape of individual particles and their role in specific atmospheric phenomena. To set the scene, figure 3.1 shows examples of such crystals collected by aircraft. In this chapter, we also address the radiation and dynamic environment in which crystals grow and subsequently evaporate. Crystal growth depends on the location of a crystal with respect to the cloud edge and the intervening cloud optical thickness; evaporation depends on larger scale processes as at fronts and cumulonimbus anvils and also at inversion interfaces where shear instability and resulting gravity waves produce significant effects over a range of scales. These effects lead to differing cloud radiative properties and ultimately control of the earth's radiation budget and overall climate (Liou 1986; Stephens et al. 1990; Liou and Takano 1994; Takano and Liou 1995; Mishchenko et al. 1996; Strauss et al. 1997; Macke et al. 1998). A growing crystal implies a supersaturated or supercooled environment with respect to the solid phase and can, in general, be considered as growth from either three-fold symmetry overlying a needle, (NASA DC-8,TOGA COARE,-48°C, deep tropical convection, 1993). The replica visually shows a uniformity of color in vertical illumination, indicating a thin crystal a few micrometers thick, uniform to ±0.05 μm. e. Replica of needles, small scalene and triangular three-fold symmetry plates, hexagonal plates, columns, and irregular crystals collected by D.L.R. Falcon in thin cirrus over the Alps, temperature -55°C, October 29,1992. (Courtesy Dr. P. Wendling.) f. Replica of crystals from the evaporating tip of a contrail formed 50 s earlier by the NASA 757 aircraft sampled from the NASA DC-8. Multiple trigonal symmetry crystals are present, with a 60° rotation (left side), along with hexagonal and scalene and triangle crystals, concentration 10/cm3. Clear sky environment over Kansas, temperature -52°C, 1840-1900Z, 4 May 1996.
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« CONVENIOS DE ASOCIACIÓN (ART.355 C. P. ) ». Dans Manual de Contratación de la Administración pública 4 ed. Reforma de la ley 80 de 1993. Incluye Decreto 1082 de 2015, 1073–100. Universidad del Externado de Colombia, 2005. http://dx.doi.org/10.2307/j.ctv1503j96.11.
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Petty, Wayne. « C. P. E. Bach and the fine art of transposition ». Dans Schenker Studies 2, 49–66. Cambridge University Press, 1999. http://dx.doi.org/10.1017/cbo9780511470295.006.
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Straus, Joseph N. « Aaron Copland, Piano Variations, Theme (1930) ». Dans The Art of Post-Tonal Analysis, 33–38. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780197543979.003.0008.
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In this theme, the process of variation with respect to a four-note motto—E-C-D♯-C♯—is continuous. The theme moves through different collectional environments (octatonic and pentatonic) and engages triadic transformations (L, P, R, SLIDE, and HEXPOLE). Ultimately, it can be thought of in relation to the tonality of C♯ minor, but not in any traditional way.
Actes de conférences sur le sujet "Art. 52 c.p"
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Essien, E. M., et A. L. Inyang. « CHANGES IN PLATELET SURVIVAL AND SIALIC ACID CONCENTRATION IN PLASMODIUM BERGEI INFECTED RATS ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643974.
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Reduced circulating platelet count sometimes to thrombocytopenic levels in man and normally severe thrombocytopenia in animals are well known features of acute Plasmodium falciparum or experimental P. bergei infections in these respective organisms. Suggested mechanism(s), disseminated intravascular coagulation or immune mediated mechanism, thought to be involved in these observations are disputed. Shortened platelet survival has been reported in man.We now present data on platelet survival and total platelet sialic acid concentration in P. bergei-infected Wistar rats. A total of 52 rats were used. For the platelet survival studies each of the 8 suckling test animals was infected by intraperi-toneal route with mouse-passaged P. bergei 4-5 days before inaction of Cr-labelled homologous rat platelets (50 μCi Na51 CrC4/rat) the platelets being obtained from adult Wistarrats. Blood samples were then collected 2 hr after the injection (zero hr sample) and subsequently at 17.0, 42.5 and 66 hr s.Platelet recovery and survival curves were determined on these samples. It was found dat fewer platelets (as % recovery) were obtained from each infected rat sample compared with control, the difference was significant in the 42.5 and 66 hr samples: 7.9 ± 8.1 (test) vs 41.4 ± 15.2% (C) for 42.5 hr and 2.8 ±4.1 (t) vs 26.8 ± 6.2% (C) for the 66 hr samples (p < 0.005 for each). For sialic acid determinations, 40 suckling Wistar rats (30 test, 10 control) were treated as for survival studies.At identical periods, blood was collected, washed platelets obtained, lysed and protein and total sialic acid determined by Lowry (1951) and Aminoff (1961) methods respectively. Total sialic acid of 7.02 ± 4.21 nM/mg protein at 42.5 hrs and 4.8 ± 2.14 at 66 hrs were significantly less than control value of 11.43 nm/mg protein and also showed a negative correlation (r = -0.95) with % parasitaemia.It is concluded that P. bergei infection causes a reduction in total platelet sialic acid with resultant significant shortening of the platelet life span.
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Schwaebisch, Sabine. « P-52 Our living wall – art, fun, stories and feeling connected ». Dans People, Partnerships and Potential, 16 – 18 November 2016, Liverpool. British Medical Journal Publishing Group, 2016. http://dx.doi.org/10.1136/bmjspcare-2016-001245.76.
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Nagy, Robertbela, Ildiko Pasc margit, Tiberiu Vesselenyi et Florin Popentiuvladicescu. « EDUCATIONAL COMMAND SYSTEM EMPLOYING THE ABB IRB 1600 INDUSTRIAL ROBOT ». Dans eLSE 2015. Carol I National Defence University Publishing House, 2015. http://dx.doi.org/10.12753/2066-026x-15-216.
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In this article we present an educational achievement of an alternative control of the IRB1600 ABB robot, using an explicit path specification, using a laser pointer and a CCD camera. With this system we measured the execution times of instructions data transfer between computers and robot equipment system to evaluate and improve the quality of similar systems in which there are mechatronics and computer processes that require synchronization of several adjacent processes. The experimental recorded data will be analyzed using Self-Organizing Feature Maps (SOFM) and as result it is shown that in the transmission of data sets significant run time dependencies can not be found. Also a run time prediction method will be developed and tested using Nonliniar AutoRegressive (NAR) type neural networks. The method has satisfactory result. M., Fernandez-Delgado, M., Reboreda, E., Cernadas, S., Barro, A comparison of several neural networks to predict the execution times in injection molding production for automotive industry, Neural Comput & Applic (2010) 19:741-754, DOI 10.1007/s00521-009-0332-5, Springer-Verlag London Limited 2010. G., P., Zhang, V., Berardi, Time series forecasting with neural network ensembles: an application for exchange, rate prediction. Journal of the Operational Research Society, 52, 652-664., 2001. C. A. Mitrea, C. K. M. Lee and Z. Wu, A Comparison between Neural Networks and Traditional Forecasting Methods: A Case Study, International Journal of Engineering Business Management, Vol. 1, No. 2 (2009) pp. 19-24 S., Hajar Arbain, A., Wibowo, Neural Networks Based Nonlinear Time Series Regression for Water Level Forecasting of Dungun River, Journal of Computer Science 8 (9): 1506-1513, 2012, ISSN 1549-3636, 2012 Science Publications S., Dietz, Autoregressive Neural Network Processes, Univariate, Multivariate and Cointegrated Models with Application to the German Automobile Industry Inaugural-Dissertation zur Erlangung des akademischen Grades eines Doktors der Wirtschaftswissenschaften der Universit?t Passau, Oktober 2010.
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Watts, I. S., R. J. Keery et P. Lumley. « DIFFERENTIAL EFFECT OF TEMPORARY Ca2+ DEPRIVATION UPON ADP-AND COLLAGEN-INDUCED PLATELET AGGREGATION IN HUMAN WHOLE BLOOD ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644467.
Texte intégralRésumé :
In platelets exposed to chelating agents at 37°C and recalcified, aggregation to ADP, adrenaline, collagen and thrombin were either abolished or markedly reduced (1). This phenomenon has been suggested to be caused by disruption, by Ca2+ deprivation, of the fibrinogen receptor (glycoprotein lib Ilia complex) on the surface of the platelet (2). This effect was dependent on the exposure time of Ca2+ chelators and was reduced at lower temperatures. We have investigated the effect of exposure of human platelets to EGTA upon aggregation to a range of agonists at both 37 and 25°C. EGTA (5 mM) was incubated with citrated (12.9 mM) whole blood for either 0, 1, 5, 15 or 30 min. One minute following recalcification (5 mM CaCl2), full aggregation concentration-response curves were constructed to ADP and adrenaline (0.1 to 3 μM), PAF (3 to 100 nM), collagen (0.1 to 4 μg/ml) and U46619 (0.03 to 1 μM), using a platelet counting technique (3). At 25°C, EGTA produced little or no significant loss of sensitivity to any agonist. At 37°C marked rightward shifts of the ADP, adrenaline and PAF aggregation curves occurred which were related to the time of incubation with EGTA (e.g. ADP concentration ratios (CR) of 2.0 (0.8-4.8), 4.7 (2.1-10.7), › 186.6 (135.2-257.6) (95% confidence intervals n=4) obtained at 1, 5 and 15 min respectively). Following 30 min incubation aggregation to all three agonists was abolished (up to ADP 300 pM; adrenaline 100 μM; PAF 10 μM). In contrast, whilst collagen and U46619 concentration-effect curves were displaced to the right following 30 minutes exposure to EGTA (CR =13.6 (6.1-30.4) and 9.0 (4.3-18.7) respectively, n=4) full aggregation curves could still be established. Furthermore, a 60 min incubation with EGTA caused little further effect. Our findings suggest platelet agonists such as collagen and U46619, but not ADP, adrenaline and PAF, can evoke expression of a population of fibrinogen receptor sites involved in platelet aggregation that are inaccessible to EGTA.(1) Zucker, MB & Grant, RA (1978). Blood, 52, 505. (2)Shattil, SJ et al. (1985). Blood, 66, 92. (3) Lumley, P & Humphrey, PPA (1981). J. Pharm. Methods, 6, 153.
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Barreto Fernandes, Francisco António, et Bernabé Hernandis Ortuño. « Usability and User-Centered Design - User Evaluation Experience in Self-Checkout Technologies ». Dans Systems & Design 2017. Valencia : Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/sd2017.2017.6634.
Texte intégralRésumé :
The increasing advance of the new technologies applied in the retail market, make it common to sell products without the personal contact between seller and buyer, being the registration and payment of the products made in electronic equipment of self-checkout. The large-scale use of these devices forces the consumer to participate in the service process, which was previously done through interaction with the company's employees. The user of the self-checkout system thus performs all the steps of the purchase, from weighing the products, registering them and making the payment. This is seen as a partial employee, whose participation or performance in providing services can be used by the company to improve the quality of its operations (KELLEY, et al 1993). However this participation does not always satisfy the user, and may cause negative experiences related to usability failures. This article presents the results of the evaluation by the users of the self-checkout system. The data were collected in Portugal through a questionnaire to 400 users. The study analyzes the degree of satisfaction regarding the quality and usability of the system, the degree of motivation for its adoption, as well as the profile of the users. Analysis of the sample data reveals that users have basic or higher education and use new technologies very often. They also have a high domain of the system and an easy learning of its use. The reason for using self-checkout instead of the traditional checkout is mainly due to "queues at checkout with operator" and "at the small volume of products". In general, the sample reveals a high degree of satisfaction with the service and with quality, however, in comparative terms, self-checkout is not considered better than operator checkout. The evaluation of the interaction with the self-checkout was classified according to twenty-six attributes of the system. The analysis identifies five groups with similar characteristics, of which two have low scores. "Cancellation of registered articles", "search for articles without a bar code", "manual registration", "bagging area", "error messages", "weight sensor" and “invoice request "are seven critical attributes of the system. The results indicate that the usability analysis oriented to the self-checkout service can be determinant for the user-system interaction. The implications of empirical findings are discussed together with guidelines for future research.Keywords: Interaction Design, Self service, Self-checkout, User evaluation, UsabilityReferencias ABRAHÃO, J., et al (2013). Ergonomia e Usabilidade. 1ª Edição. São Paulo: Blucher. ALEXANDRE, J. W. C., et al (2013). Análise do número de categorias da escala de Likert aplicada à gestão pela qualidade total através da teoria da resposta ao item. In: XXIII Encontro Nacional de Engenharia de Produção, Ouro Preto. BOOTH, P. (2014). An Introduction to Human-Computer Interaction (Psychology Revivals). London Taylor and Francis. CASTRO, D., ATKINSON, R., EZELL, J., (2010). Embracing the Self-Service Economy, Information Technology and Innovation Foundation. Available at SSRN: http://dx.doi.org/10.2139/ssrn.1590982 CHANG, L.A. (1994). A psychometric evaluation of 4-point and 6-point Likert-type scale in relation to reliability and validity. Applied Psychological Measurement. v. 18, n. 2, p. 05-15. DABHOLKAR, P. A. (1996). Consumer Evaluations of New Technology-based Self-service Options: An Investigation of Alternative Models of Service Quality. International Journal of Research in Marketing, Vol. 13, pp. 29-51. DABHOLKAR, P. A., BAGOZZI, R. P. (2002). An Attitudinal Model of Technology-based Selfservice: Moderating Effects of Consumer Traits and Situational Factors. Journal of the Academy of Marketing Science, Vol. 30 (3), pp. 184-201. DABHOLKAR, P. A., BOBBITT, L. M. & LEE, E. (2003). Understanding Consumer Motivation and Behavior related to Self-scanning in Retailing. International Journal of Service Industry Management, Vol. 14 (1), pp. 59-95. DIX, A. et al (2004). Human-Computer Interaction. Third edition. Pearson/Prentice-Hall. New York. FERNANDES, F. et al, (2015). Do Ensaio à Investigação – Textos Breves Sobre a Investigação, Bernabé Hernandis, Carmen Lloret e Francisco Sanmartín (Editores), Oficina de Acción Internacional - Universidade Politécnica de Valência Edições ESAD.cr/IPL, Leiria. HELANDER, M., LANDAUER, T., PRABHU, P. (1997). Handbook of Human – Computer Interaction. North–Holland: Elsevier. KALLWEIT, K., SPREER, P. & TOPOROWSKI, W. (2014). Why do Customers use Self-service Information Technologies in Retail? The Mediating Effect of Perceived Service Quality. Journal of Retailing and Consumer Services, Vol. 21, pp. 268-276. KELLEY SW, HOFFMAN KD, DAVIS MA. (1993). A typology of retail failures and recoveries. J Retailing. 69(4):429 – 52.
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Wu, Leyi, Jing Luo et Huihui Guo. « An interactive design solution for prenatal emotional nursing of pregnant women ». Dans 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001973.
Texte intégralRésumé :
With the continuous development of interactive technology, informatization has begun to integrate into people's life[1].Having been neglected in history, postpartum depression reminds us that we need to pay attention to maternal emotional needs and prenatal care[2]. In the current situation, it is worth researching the interactive products for prenatal emotional care. According to the survey, it is not difficult to find that some speech emotion and facial expression recognition technologies in artificial intelligence are developing Which have large potential for extensive use.[3,4]. Therefore, it is necessary and feasible to design prenatal emotional diagnosis tools for pregnant women. This study has designed a product to care for pregnant women by identifying their emotional needs through AI recognition technologies. Appropriate prenatal intervention is conducive to the prevention of postpartum depression[5,6] . The use of artificial intelligence recognition technology can provide an appropriate emotional care plan. This can reduce the difficulty of training medical personnel and the difficulty of relatives caring for pregnant women. Therefore, the risk of postpartum depression can be reduced. QUESTIONCollecting opinions and information from previous studies is an important reference for this study. Therefore, this study needs to solve the following problems.1) How to design an artificial intelligence product that can accurately diagnose the emotion of pregnant women?2) How to integrate AI facial emotion recognition technology?3) How to help nurses and their families take care of users more professionally and easily through the information database?4) How to adapt the emotional care program provided by interactive products to different pregnant women? Methods:the research methods of this study are as follows:1) Observing the working process of artificial midwives and psychologists to find Which part can be assisted by machines[7].2) To understand the emotional needs of pregnant women through interview.3) To brainstorm according to the real data collected before and research findings, and then design interactive products that can practically solve the emotional care problems of pregnant women.4) Through the experiment of AI emotion recognition technologies, the feasibility of emotion recognition is verified. CONCLUSIONS:With the continuous development of artificial intelligence, more and more artificial intelligence products have entered our life [1]. This study is aimed to help pregnant women prevent prenatal and postpartum depression and maintain their health through artificial intelligence interaction technologies. This study is exploring the solution under the help of artificial intelligence after studying the problem that prenatal and postpartum emotion are neglected. This design is still in the conceptual design stage, but it seems only a matter of time before this design is applied in the future[8]. REFERENCES:[1]. Lee H S , Lee J . Applying Artificial Intelligence in Physical Education and Future Perspectives. 2021.[2]. Beck C T . Postpartum depression: it isn't just the blues.[J]. American Journal of Nursing, 2006, 106(5):40-50.[3].Ramakrishnan S , Emary I M M E . Speech emotion recognition approaches in human computer interaction[J]. Telecommunication Systems, 2013, 52(3):OnLine-First.[4]. Samara A , Galway L , Bond R , et al. Affective state detection via facial expression analysis within a human–computer interaction context[J]. Journal of Ambient Intelligence & Humanized Computing, 2017.[5]. Clatworthy J . The effectiveness of antenatal interventions to prevent postnatal depression in high-risk women[J]. Journal of Affective Disorders, 2012, 137(1-3):25-34.[6]. Ju C H , Hye K J , Jae L J . Antenatal Cognitive-behavioral Therapy for Prevention of Postpartum Depression: A Pilot Study[J]. Yonsei Medical Journal, 2008, 49(4):553-.[7]. Fletcher A , Murphy M , Leahy-Warren P . Midwives' experiences of caring for women's emotional and mental well-being during pregnancy[J]. Journal of Clinical Nursing, 2021.[8]. Jin X , Liu C , Xu T , et al. Artificial intelligence biosensors: Challenges and prospects[J]. Biosensors & Bioelectronics, 2020, 165:112412.
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Oliveira, Westerley, Michael Canesche, Lucas Reis, José Nacif et Ricardo Ferreira. « Design Exploration of Machine Learning Data-Flows onto Heterogeneous Reconfigurable Hardware ». Dans XXI Simpósio em Sistemas Computacionais de Alto Desempenho. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/wscad.2020.14063.
Texte intégralRésumé :
Machine/Deep learning applications are currently the center of the attention of both industry and academia, turning these applications acceleration a very relevant research topic. Acceleration comes in different flavors, including parallelizing routines on a GPU, FPGA, or CGRA. In this work, we explore the placement and routing of Machine Learning applications dataflow graphs onto three heterogeneous CGRA architectures. We compare our results with the homogeneous case and with one of the state-of-the-art tools for placement and routing (P&R). Our algorithm executed, on average, 52% faster than Versatile Place&Routing (VPR) 8.1. Furthermore, a heterogeneous architecture reduces the cost without losing performance in 76% of the cases.
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Thomas, David, Emma Bermingham, Mark Roberts et Wayne Young. « An investigation into the effect of high fat and carbohydrate diets on a range of biomarkers associated with pancreatitis in dogs ». Dans 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/uvdt4784.
Texte intégralRésumé :
Studies suggest that dogs preferentially choose fat as their major dietary energy source (59-63% of the total metabolisable energy (ME) content of the diet). However, high fat diets have been linked to the development of pancreatitis in dogs. This study investigated several biomarkers associated with pancreatitis in dogs fed either a high fat (HF; Protein: Fat: Carbohydrate content; 35%:63%:2% ME; n= 10 dogs) or high carbohydrate (HC; Protein: Fat: Carbohydrate content; 17%:32%:51% ME) diet.A high fat meal tolerance test (MTT) was undertaken on dogs (n=20) at baseline consuming a commercial dry food diet (Protein: Fat: Carbohydrate content; 23%:25%:52% on an ME basis) and then again after 8 weeks consuming either a HF (n=10) or HC (n=10) diet. Briefly, after an overnight fast, dogs were fed a single meal containing 100% of their daily requirements (P: F: C content; 35%:63%:2% ME). Each dog was then blood sampled 1, 2, 3, 4, 5, 6, 12, and 24 hours post-prandially. Samples were analysed for plasma triglycerides and markers of pancreatitis (i.e., pancreatic lipase, endotoxin, C-reactive protein, Interleukin 1-alpha, Interleukin 6 and Tumour necrosis factor-alpha). The postprandial peak plasma concentration of triglycerides (Cmax) were higher (p less than 0.001) at baseline, compared to after feeding of the either the HC or HF diets for 8 weeks. This suggests dietary components such as moisture level, specific ingredients, level of diet processing, and possibly apparent nutrient digestibility were potential factors driving this response. There was no effect of feeding either HF or HC diets on Cmax values (P >0.05) during the final MTT. This study suggests that feeding a HF diet for 8 weeks does not elevate blood markers associated with pancreatitis, with the serum biochemistry and complete blood count indicating the dogs remained clinically healthy.
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Consonni, Stefano, Giovanni Lozza, Giampaolo Pelliccia, Stefano Rossini et Francesco Saviano. « Chemical-Looping Combustion for Combined Cycles With CO2 Capture ». Dans ASME Turbo Expo 2004 : Power for Land, Sea, and Air. ASMEDC, 2004. http://dx.doi.org/10.1115/gt2004-53503.
Texte intégralRésumé :
Chemical-Looping Combustion (CLC) is a process where fuel oxidation is carried out through an intermediate agent — a metal oxide — circulated across two fluidized bed reactors: a reduction reactor, where an endothermic reaction reduces the metal oxide and oxidizes the fuel, and an oxidation reactor, where an exothermic reaction oxidizes the metal oxide in air. Overall, the system carries out the same job of a conventional combustor, with the fundamental advantage of segregating the oxidation products (CO2 and H2O) into an output flow free of nitrogen and excess oxygen. The flow exiting the reduction reactor consists of water and CO2, the latter readily available for liquefaction, transport and long-term storage. The hot, vitiated air from the oxidation reactor is the means to produce power through a thermodynamic cycle. This paper reports of a study supported by the ENI group to assess the potential of the integration between CLC and combined gas-steam power cycles. More specifically, we focus on four issues: (i) optimization of plant configuration; (ii) prediction of overall efficiency; (iii) use of commercial gas turbines; (iv) preliminary economic estimates. The CLC system is based on iron oxides which, to maintain their physical characteristics, must operate below 900–1000°C. Given the crucial importance of the temperature of the vitiated air generated by CLC on the performance of the combined cycle, we consider two options: (i) “unfired” systems, where natural gas is fed only to the CLC system, (ii) “fired” systems, where the vitiated air is supplementary fired to reach gas turbine inlet temperatures ranging 1000–1200°C. Results show that unfired configurations with maximum process temperature 850–1050°C and zero emissions reach net LHV plant efficiencies ranging 43–48%. Fired cycles where temperature is raised from 850 to 1200°C by supplementary firing can achieve 52% net LHV efficiency with CO2 emission about one half of those of a state-of-the-art combined cycles. Fired configurations allow significant capital cost and fuel cost savings compared to unfired configurations; however, a carbon tax high enough to make them attractive (close to 50 €/ton) would undermine these advantages.
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Navarra, Kelly R., Douglas C. Rabe et Larry P. Goss. « The Application of Pressure- and Temperature-Sensitive Paints to an Advanced Compressor ». Dans ASME Turbo Expo 2000 : Power for Land, Sea, and Air. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/2000-gt-0614.
Texte intégralRésumé :
An innovative pressure-measurement technique that employs the tools of molecular spectroscopy has been widely investigated by the aerospace community. Measurements are made via oxygen-sensitive molecules attached to the surface of interest as a coating, or paint. The pressure-sensitive-paint (PSP) technique is now commonly used in stationary wind-tunnel tests; this paper presents the use of this technique in advanced turbomachinery applications. New pressure- and temperature-sensitive paints (P/TSPs) have been developed for application to a state-of-the-art transonic compressor where pressures up to 1.4 atm and surface temperatures to 90°C are expected for the suction surface of the first-stage rotor. PSP and TSP data images have been acquired from the suction surface of the first-stage rotor at 85% of the corrected design speed for the compressor near-stall condition. A comparison to over-the-rotor pressure transducer measurements will be presented.