Littérature scientifique sur le sujet « Antonio Costanzi »

El ensayo se propone dibujar un mapa, necesariamente parcial, de algunas obras y autores que contribuyen a definir la imagen contemporánea del marxismo y el posmarxismo. Un mapa organizado a partir de palabras clave como capitalismo (David Harvey, Jacques Bidet, Gianfranco La Grassa, Robert Kurz), clase (Domenico Losurdo, Ernesto Laclau, Etienne Balibar), ideología (Slavoj Žižek, Pierre Macherey, Frederic Jameson), diálectica (Roberto Finelli, Costanzo Preve, Antonio Negri), Estado y política (Alain Badiou, Sylvain Lazarus, Chritian Laval, Mario Tronti). Una serie de posiciones muy distintas, a las que los autores proponen algunas problemáticas transversales: la grandeza y los límites del encuentro con el pensamiento post-estructuralista; la dificultad de derivar de la crítica al capitalismo la afirmación de un “nuevo orden”, que sepa dirigirse a sus víctimas; el fin de la unión entre lo que de fértil hay en el marxismo y la cultura de la izquierda posmoderna; la diferencia entre la práctica teórica y las formas del antagonismo en el horizonte neoliberal contemporáneo, con la reaparición de nociones olvidadas demasiado rápidamente como “pueblo”, “nación” o “identidad”.

Il seguente saggio intende analizzare un romanzo di Antonio Scurati: <i>Il bambino che sognava la fine del mondo</i> (2009). Quest’opera, ai confini tra realtà, finzione e autofinzione, si inserisce perfettamente all’interno del dibattito sul <i>New Realism</i>. Scurati non ci offre solamente la rielaborazione romanzesca di due storie di presunta pedofilia, ma ci propone una spiegazione di come una macchinazione possa essere montata, a livello nazionale, grazie ai giornali, alla televisione ed a altri mezzi di comunicazione. Partendo da alcune teorie di Jean Baudrillard sul simulacro e sulla iperrealtà, vengono qui messi in risalto alcuni dei meccanismi che generano una realtà simulata, la quale risulta essere più reale del reale e trasporta l’essere umano all’interno di un costante <i>reality show</i>. In una realtà trasformatasi in <i>reality show</i> svaniscono i labili confini tra attori e spettatori, tra vittime e carnefici, tra accusatori e accusati, e tra realtà e finzione e questo crea smarrimento in una società postindustriale quale la nostra, in cui si vive attanagliati da una paura le cui origini sono difficili da identificare.

Abstract Introduction: Patients with BRCA1/2 mutations have a higher risk of developing breast cancer compared to the wild-type population. For patients with a BRCA mutation, there are no specific recommendations for surgical management. The aim of this study was therefore to retrospectively investigate overall survival (OS) and recurrence-free survival (RFS) of BRCA mutated patients with localized invasive breast cancer, by comparing conservative surgery versus mastectomy. Methods: This study was based on data from the Côte d’Or breast and gynecological cancer registry. Data from patients with a constitutional BRCA1/2 mutation who presented with invasive breast cancer were collected retrospectively from 1998 to 2018. The Kaplan-Meier method was used to describe RFS and OS. Results:A total of 104 patients were included in the analysis, of whom 69 had conservative surgery and 35 underwent mastectomy. Regarding survival, there was no significant difference in OS (HR =1.49; 95% confidence interval (CI) [0.76-2.93], p=0.25). Similarly, there was no significant difference in RFS (HR =1.40; 95% CI [0.81-2.40], p=0.22), survival without homolateral recurrence (HR =0.88; 95% CI [0.30-2.61], p=0.89), without contralateral recurrence (HR =1.50; 95% CI [0.55-4.09], p=0.42), or without distant metastatic recurrence (HR =1.42, 95% CI [0.69-2.90], p=0.33). Conclusion: In invasive breast cancer in a patient with a germline BRCA1/2 mutation, conservative surgery, when possible, appears to be a feasible option over total mastectomy, with no difference in overall survival. However, the patient should be informed of the aggressive nature of recurrence in this population requiring chemotherapy in most cases. Citation Format: CLEMENTINE JANKOWSKI, Katia Mahiou, Vincent Laura, Hélène Costaz, Marie-Martine padéano, Sylvain Causeret, Ariane Mamguem, Sandrine Dabakuyo, CHARLES COUTANT. Impact of breast surgical procedure on survival in BRCA mutated patients with invasive breast cancer: mastectomy versus conservative treatment [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-09-11.

Abstract Clinical decisions on precision and immuno-oncology therapies are based on predictive biomarkers commonly obtained from a single metastatic biopsy or archived primary tumor tissue. Circulating genomic biomarkers offer a minimally invasive approach to monitor intra-patient tumor heterogeneity and detect in real-time the clinically-relevant evolving clonal architecture. Although currently underutilized, we hypothesize that single-cell DNA next generation sequencing (scNGS) of circulating tumor cells (CTC) is a particularly well-suited method to complement biomarker information obtained from tissue and cell-free circulating tumor DNA (ctDNA). In this study we analyzed 113 individual CTC, 21 ctDNA, and 15 white blood cells (WBC) samples, from 15 CTC-positive lobular breast cancer patients, four of whom had CTC available at both metastatic baseline and after progression on a variety of therapies chosen at their physician’s discretion. Clinical NGS data from 15 tumor tissue biopsies obtained using a ~1700-gene DNA panel and whole transcriptome sequencing were available for comparison. CTC were enriched with the CellSearch® system and isolated as single cells with the DEPArray™ system. Whole genome amplified CTC and WBC, as well as ctDNA underwent scNGS with the Oncomine Comprehensive Assay covering ~500 genes and 1.1Mb of genomic space to detect mutations, copy number alterations, tumor mutation burden (TMB) and microsatellite instability (MSI). 99.1% of single cells and 95.2% of ctDNA samples were informative, with a mean sequencing depth of 664x. Using our previously developed, CTC-based precision medicine reporting platform, MI-CTCSeq, CTC in 9 of 15 patients (60%) had mutations that were actionable by FDA-approved targeted therapies including in the oncogenes PIK3CA and FGFR2 and HER2. 3 of these 9 patients (33%) harbored actionable alterations not shared between all 3 analyte types (tissue, CTC and ctDNA). These included 3 actionable mutations found in CTC and ctDNA only, 1 in tissue and ctDNA only, and 1 in ctDNA only. However, 2 of those ctDNA mutations were identified near the limit of detection and with a priori knowledge of their presence from tissue or CTC. Further, 1 patient with plentiful CTC had no detectable ctDNA and one patient’s tissue biopsy was inadequate for sequencing while both liquid biopsy analytes were abundant. 13 patients (87%) displayed intra-patient, inter-CTC genomic heterogeneity of putative driver mutations. 1 of 4 (25%) patients with CTC available in &gt;1 timepoint displayed fluctuations in their CTC subclonal makeup between timepoints. Data from this patient’s 2 tissue biopsies, 3 ctDNA samples, and 27 individual CTC over 4 timepoints combined to reveal in unprecedented detail inter-metastatic lesion and inter-CTC heterogeneity and tumor evolution in response to endocrine and immunotherapy selective pressures. ScNGS of CTC helped provide an additional level of detail not appreciated by sequencing of the other two analyte types. In another patient, CTC were composed of 2 subclones which were indistinguishable by ctDNA, 1 of which appears to have not been sampled by the tissue biopsy. Using a novel method, we enabled detection of single-cell CTC TMB and MSI. CTC TMB scores (dichotomized as above/below 10 mutations/Mb) were 100% concordant with those measured in the corresponding tissue biopsies. Further, in a novel observation, we detected intra patient, inter-CTC heterogeneity of TMB and MSI, which has potential implications for immunotherapy response and development of resistance. Taken together, these data support the non-invasive biomarker interrogation and monitoring by liquid biopsy that incorporates CTC scNGS and complements tissue in informing precision and immuno-oncology approaches. This may have important implications for appropriate treatment selection and identification of therapeutic resistance mechanisms. Citation Format: Andi Cani, Emily Dolce, Alissa Turnbull, Kevin Hu, Chia-Jen Liu, Elizabeth Darga, Dan Robinson, Yi-Mi Wu, Dafydd G. Thomas, Costanza Paoletti, Scott Tomlins, James Rae, Aaron Udager, Arul Chinnaiyan, Erin F. Cobain, Daniel F. Hayes. Serial monitoring of circulating tumor cells and circulating tumor DNA in metastatic lobular breast cancer identifies intra-tumor heterogeneity and precision and immuno-oncology biomarkers of therapeutic importance [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-02-04.

BackgroundThe management of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) is often relying on a multidisciplinary approach with different specialists evaluating the patient for treatment choices. The ultimate impact of such management on the use of systemic glucocorticoids and more innovative drugs such as biologics and small molecules, however, is unclear. Artificial intelligence tools, particularly natural language processing and machine learning, allow to manage large datasets and investigate associations between variables.ObjectivesTo use a natural language processing approach to demonstrate whether a multidisciplinary approach to RA or PsA changes treatment choices.MethodsWe analysed the clinical notes of hospital encounters between 2017 and 2020 of patients with a terminated or ongoing care process at outpatient clinics included in the Humanitas Center for immune-mediated disease. To extract structured information from text data we used regular expressions (RegEx), a technique that allows to define elastic search patterns. RegEx were also used to detect negations to consider only affirmative citation of diseases or prescribed therapy. Care processes were described by binary flags which express the presence of RA or PsA and the prescription of glucocorticoids and biologics /small molecules for each patient. Working with only categorical data, we relied on the chi squared test to detect possible correlations between prescribed treatments and the characteristics of the care process, including whether a multidisciplinary evaluation had occurred.ResultsOur analysis included 1839 patients with RA (77% women, mean+standard deviation age 58±16 years) and 1652 patients with PsA (46% women, age 57±15 years), accounting for 5517 and 3992 outpatient visits with different specialists over the study period, respectively. Among patients with RA and PsA, 378 (22%) and 371 (25%) were prescribed biologics or small molecules, respectively, while 830 (47%) RA and 431 (29%) PsA cases received a prescription for systemic glucocorticoids during one of the visits and patients seen three of more times by the rheumatologists received significantly more biologics / small molecules. Importantly, 4.5% of patients with RA and 9.4% of patients with PsA were evaluated also by dermatology, gastroenterology, allergy and pulmonary disease specialists and these patients were treated more frequently with glucocorticoids (70% vs.47% for RA, P<0.001; 60% vs. 29% for PsA, P<0.001) as well as with biologics / small molecules (42% vs. 22% for RA, P<0.001; 58% vs. 25% in PsA, P<0.001).ConclusionNatural language processing and machine learning were applied to unstructured electronic clinical charts in a large Center dedicated to immune-mediated diseases and allowed to demonstrate that patients with RA or PsA undergoing multiple evaluations are more likely to receive biologics or small molecules.Disclosure of InterestsPierandrea Moranding: None declared, Fiore Maffia: None declared, Francesca Puggioni Consultant of: Sanofi, GSK, Novartis, Teva, Francesca Motta: None declared, Matteo Vecellio: None declared, Antonio Costanzo Speakers bureau: bbvie, Almirall, Amgen, Lilly, Novartis, Galderma, Boehringer, Janssen, Leo Pfarma, Pfizer Sanofi, Celgene, Paid instructor for: Abbvie, Almirall, Amgen, Lilly, Novartis, Galderma, Boehringer, Janssen Leo Pfarma Pfizer, Sanofi, Celgene, Grant/research support from: bbvie, Janssen, Novartis, Victor Savevski: None declared, Carlo Selmi Speakers bureau: AbbVie, Amgen, Alfa-Wassermann, Biogen, Celgene, Eli-Lilly, Gilead, Janssen, MSD, Novartis, Pfizer, Sanofi-Genzyme, Paid instructor for: AbbVie, Amgen, Alfa-Wassermann, Biogen, Celgene, Eli-Lilly, Gilead, Janssen, MSD, Novartis, Pfizer, Sanofi-Genzyme, Consultant of: AbbVie, Amgen, Alfa-Wassermann, Biogen, Celgene, Eli-Lilly, Gilead, Janssen, MSD, Novartis, Pfizer, Sanofi-Genzyme, Grant/research support from: AbbVie, Amgen, Janssen, Pfizer

My list of 66 medically related anniversaries for 2023 (events in years ending ’23 and’73) includes: ● foundation of the Chelsea Physic Garden (1673); ● foundation of The Lancet by Thomas Wakley (October 1823); ● Roe v Wade (1973); ● Twenty five births include: Hans Berger, German neurologist; Aimé Bonpland, French physician and botanist; Alexis Carrel, French surgeon and Nobel prize winner; Lloyd Conover, American pharmaceutical chemist; Félix d'Herelle, French-Canadian microbiologist; Théodore de Mayerne, Swiss physician; Carl Djerassi, American pharmaceutical chemist and novelist; Sigismund Elsholtz, German physician, botanist, and alchemist; Daniel Gajdusek, American virologist; Beatrix Hamburg, American psychiatrist; Richard Mead, English physician; Arthur Jensen, American educational psychologist; Otto Loewi, German pharmacologist; Georg Balthasar Metzger, German physician and scientist; William P Murphy Jr, American physician and inventor of medical devices; William Petty, English physician and political economist; Arnold S Relman, American physician and editor; Caspar Schamberger, German surgeon; Giovanni Antonio Scopoli, Italian physician and scientist; Ludwik Teichmann, Polish physician and anatomist; Alfred Russell Wallace, English naturalist; and Thomas Young, English scientist and polymath; ● Thirteen deaths include: Francis Anthony, English apothecary, physician, and alchemist; Matthew Baillie, Scottish physician and pathologist; John Caius, English physician; Regnier De Graaf, Dutch physician, physiologist, and anatomist; Walter Rudolf Hess, Swiss physiologist; Edward Jenner, English physician; Dickinson W Richards, American physician; Wilhelm Röntgen, German physicist; Antony van Leeuwenhoek, Dutch microscopist; Justus von Liebig, German chemist; and Selman Waksman, Ukrainian-American biochemist; ● Eleven biomedical texts published, written by Avicenna, Persian physician, astronomer, and philosopher; Gaspard Bauhin, Swiss botanist; William Budd, English physician; Aleixeu de Abreu, Portuguese physician and tropical pathologist; John Lelamour, English schoolmaster; Lucretius, Roman poet and philosopher; Marcello Malpighi, Italian physician; Girolamo Mercuriale, Italian physician; Raymond Pearl, American biologist; Costanzo Varolio, Italian anatomist and physician; Charles White, English physician; and Wilhelm Wundt, German physiologist; ● compilation of the Lelamour Herbal by John Lelamour, English schoolmaster (1373); ● anatomical, biochemical, haematological, microbiological, and physiological observations by Gasparus Aselli, Italian physician; Gerhard Henrik Armauer Hansen, Norwegian physician; William Prout, English chemist, physician, and theologian; Gaston Ramon, French biologist; Hilaire-Marin Rouelle, French chemist; and Antony van Leeuwenhoek, Dutch microscopist; ● Foundation of the pharmaceutical companies Novo Nordisk in Denmark (1923) and Sanofi in France (1973); ● Nobel prizes awarded to Banting and Macleod (1923) and to von Frisch, Lorenz, and Tinbergen (1973).

2013 - 2014
La tesi consiste nell’edizione critica del commento di Antonio Costanzi da Fano (Fano 1436 - 1490) a Fast. I-III, tràdito in due diverse stesure, precisamente, quella contenuta nel manoscritto BAV Vat. lat. 360 (1480) e quella testimoniata dagli esemplari dell’editio princeps dell’opera (1489). A questo materiale esegetico vanno accostate le note marginali al testo dei Fasti, contenute nel ms. BAV Chig. H.VI.204, che testimoniano la lettura dell’opera da parte dell’umanista, antecedente alla stesura del commentario. La lettura del commento di Costanzi si rivela giovevole, non soltanto perché l’opera costituisce una miniera di informazioni sulla ricezione del testo del poeta di Sulmona in età umanistica, e, più in generale, sulla storia dell’esegesi dei testi classici nell’Umanesimo, ma in quanto essa è anche preziosa fonte di notizie utili alla delineazione del réseau ideologico e culturale nel quale furono letti e commentati i Fasti nella seconda metà del secolo XV. Alla luce di ciò, al fine dunque di una più consapevole lettura del testo del commentario, l’edizione è preceduta da un’ampia introduzione, ripartita in quattro capitoli, in cui è tratteggiato un breve quadro dell’attività esegetica sui Fasti fra XI e XV secolo; sono forniti cenni sulla vita e le opere di Antonio Costanzi; sono analizzati, dal punto di vista codicologico e paleografico, i testimoni del commento; infine, sono presi in esame i documenti paratestuali (epigramma ad posteros, lettera prefatoria a Federico di Montefeltro, praefationes al commento a Fast. II e III, epilogo rivolto al lettore, lettera di Costanzi a Zagarello Gambitelli) ed è delineato il processo di gestazione redazionale dell’opera, il metodo adottato dall’umanista nell’esegesi del testo dei Fasti e l’iter di allestimento degli scolii. Seguono all’edizione del commento e delle note del manoscritto Chigiano a Fast. I-III due appendici: nella prima è data l’edizione dell’epilogo al lettore, presente in duplice stesura nel manoscritto Urbinate e nell’editio princeps, nella seconda della lettera di Costanzi a Zagarello Gambitelli, posta a chiusura degli esemplari a stampa del commentario. The thesis consists in the critical edition of Antonio Costanzi’s (Fano 1436-1490) commentary on Ovid’s Fasti, transmitted in two different versions, namely, the first one contained in the manuscript BAV Vat. Lat. 360 (1480) and the second one in the editio princeps of the work (1489). In addition to this exegetical material, there are the marginalia, contained in the ms. BAV Chig. H.VI.204, which prove a Costanzi’s lectura of the Fasti prior to the commentary. The reading of this commentary is beneficial, not only because the work is a mine of information on the fortune of the ovidian poem, and, more generically, about the exegetical history of classical texts during the Renaissance, but also because it is also an invaluable source of useful information about the ideological and cultural réseau in which Fasti were read and commented in the second half of the 15th century. So, in order of a more conscious reading of the commentary, the edition is preceded by an extensive introduction, divided in four chapters: a brief picture of 11th-15th exegesis on Fasti; life and works of Antonio Costanzi; codicological and palaeographical (and typographical) description of the witnesses of the commentary; the analysis of the paratextual documents (epigramma ad posteros, dedicatory letter to Federico da Montefeltro, praefationes to the commentary on Fast. IIII, epilogue to the reader, letter of Costanzi to Zagarello Gambitelli), the editorial process of the work, the exegetical method of the humanist and the iter of construction of the scholia. Finally, there are also two appendices: the first one contanis the edition of the epilogue to the reader; the second one the letter of Costanzi to Zagarello Gambitelli. [a cura dell'autore]
XIII n.s.

Repaso de algunos de los aspectos más destacados e interesantes del libro “Science and Art. The Painted Surface”, una obra de contenido multidisciplinar (ciencia, arte e historia) cuya lectura recomendamos.
Short review of the most important and interesting sections of the multidisciplinary science book that we strongly recommend: "Science and Art. The Painted Surface”.

In this chapter the authors analyze how unjust, biased, interested, and malevolent results topos “quid est mulier [what is a woman]?”. The authors study how, before the topos of the evil woman took shape, there already existed the topos of the learned and polyglot women. One of the first cases: princess Berta in Girart de Roussillon (ca. 1136-1180). After the topos, the authors study real, papal, and royal women who demonstrate it is false. The samples developed are women with power and knowledge from the lineages, close related with the Crown of Aragon, of the Borgia, and Aragon of Naples: Lucrecia Borgia, Isabella d'Este, Antonia del Balzo, Costanza d'Avalos, Vittoria Colonna, and Isabella of Aragon