Articles de revues sur le sujet « American Institute of Park Executives »

Dentre os fatores determinantes do sucesso obtido, destacam-se a extraordinária capacidade organizadora e a eficiente atuação da Comissão Executiva do Congresso, integrada pelas figuras exponenciais do Conde de Mayalde, Alcaide de Madri, do Prof. Dom Carlos Ruiz dei Castillo, Presidente do Instituto Espanhol de Estudos de Administração Local, de Madri; do Prof. Marcelo Caetano, eminente catedrático e jurisconsulto; do Brigadeiro França Borges, Presidente da Câmara Municipal de Lisboa; do Doutor Macedo de Barros, Secretário Executivo do certame, para citar apenas algumas personalidades da mais alta categoria, responsáveis pelo rigoroso planejamento e execução impecável aa Reunião Ibero-Americana de Lisboa.

ABSTRACT This study explores chief audit executives' perceptions of the most important performance attributes of internal auditors by professional rank and cultural cluster. A large sample of chief audit executives (CAEs) from 19 countries located in five different cultural clusters was surveyed by the Institute of Internal Auditors Research Foundation (CBOK 2006). Analysis of data generated by that survey indicates that while leadership attributes (e.g., negotiating) are perceived to be most important for upper ranks in internal auditing, technical skills (e.g., analytical) are most important for lower ranks. Also, based on the cultural relativism literature, I hypothesize and find evidence that the importance of performance attributes differs significantly by cultural cluster. For example, while Latin-American CAEs rated leadership attributes at higher levels than other cultural clusters for internal audit staff, the East-European chief audit executives assessed the importance of technical skills at higher levels than other clusters. The results of the survey provide important initial empirical support to the list of “ideal” and “desirable” performance attributes for internal auditors recently developed by the Institute of Internal Auditors (IIA 2009). Data Availability: The source of data used in this study is CBOK (2006) from the Institute of Internal Auditors Research Foundation.

It’s the new year, a new decade, and we’ve turned the page as an organization. We’ve completed our contracting process and have a new staff! We’ve contracted with Ewald Consulting to provide association management services. Under this new arrangement, we will benefit by having professional staff available to help plan our annual Conference and events, provide enhanced member services and assist the Society’s leadership in moving strategic initiatives forward. Ewald Consulting is charter accredited by the Association Management Companies Institute (AMC Institute) and charter certified by the American Society of Association Executives (ASAE).

The Birmingham Civil Rights Institute marks its twenty-fifth year as the focal point for the city’s civil rights district. Inspired by the vision of Mayor David Vann, it became a reality under the leadership of the Dr. Richard Arrington, the city’s first African American mayor. A team of committed community volunteers led the institute through thirteen years of development in spite of corporate skepticism and citizen resistance. BCRI evolved as a model for staff development, community engagement and leadership and is now a key partner in the Birmingham Civil Rights National Monument, a unit of the National Park Service established in 2017.

A entrevista discute o processo de Avaliação da Educação Superior no Brasil, sobretudo a história da criação da Comissão Especial de Avaliação (CEA) e da Comissão Nacional de Avaliação da Educação Superior (Conaes), além de problematizar a formulação das políticas de avaliação. Stela Maria Meneghelé Coordenadora Geral de Controle de Qualidade da Educação Superior da Diretoria de Avaliação da Educação Superior (Daes) do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (Inep). Bacharel e licenciada em Letras (1987), mestre em Educação (1994) e doutora (2001) pela Universidade Estadual de Campinas (Unicamp), com pós-doutorado no Instituto Internacional para a Educação Superior na América Latina e Caribe (Iesalc/Unesco, 2008), atuou como professora titular da Universidade Regional de Blumenau (2001-2009), no Programa de Pós-Graduação em Educação. Colaborou na elaboração (2003) e na implantação (2004-2006) do Sistema Nacional de Avaliação de Educação Superior (Sinaes), ao atuar como Secre tária-Executiva e Assessora Técnica da Comissão Nacional de Avaliação da Educação Superior (Conaes/MEC). Integrou a Comissão de Implantação da Universidade da Integração Latino--Americana (Unila, 2008-2010), tendo coordenado o primeiro curso oferecido por essa universidade: o Curso Latino--Americano de Especialização em Políticas Públicas e Avaliação da Educação Superior (CLAEPPAES). Em 2009 e 2010 atuou como professora visitante na Universidade Federal do Paraná (UFPR), instituição tutora da Unila. Em agosto de 2010, assumiu Consultoria Unesco para Implantação da Pró-Reitoria de Pesquisa, Pós-Graduação e Extensão da Universidade de Integração Internacional Luso Afro--Brasileira (Unilab), onde foi pró-reitora (2011-2012).

POR QUE DISCUTIR O ESTUDO RIVER? Como Presidente do Comitê Executivo do estudo RIVER, é um prazer discutir os resultados deste ensaio clínico randomizado,100% brasileiro, apresentado na sessão de Late Breaking Clinical Trials do congresso da American Heart Association (AHA) 2020. Os resultados principais foram publicados no New England Journal of Medicine , o que demonstra a força e a maturidade da cardiologia brasileira em gerar resultados com impacto clínico internacional. O estudo RIVER avaliou o tratamento com rivaroxabana em pacientes com fibrilação atrial e bioprótese mitral. Este foi um projeto colaborativo, liderado por um Comitê executivo acadêmico. O estudo nasceu na SOCESP e teve a égide e apoio científico desta sociedade para sua condução. As operações do estudo foram conduzidas pelo Instituto de Pesquisa do HCor. O estudo foi financiado pelo programa PROADI-SUS e pela Bayer. Descritores: Válvula Mitral; Fibrilação Atrial; Rivaroxabana

AbstractThis note reports on a paper presented at the American Institute of Archaeology 107th Annual Meeting (Montreal January 2006). The theme of the American Institute of Archaeology Annual meeting was ‘Management and Preservation of Cultural Heritage’. The Euesperides Project presented a paper on Euesperides (Sidi Abeid, Benghazi), the Archaic Greek settlement founded in the sixth century BC. Although the site was declared a protected area for its historical and archaeological importance, it still lacks effective protection. The site, important also from a naturalistic point of view, is used as an illegal rubbish dumping area and is awaiting a long-promised wall to prevent indiscriminate access to it.The paper stressed that many sites in Libya are in need of preservation and protection, even more so after the opening of the country to tourism. The need to develop new infrastructure, if not carefully planned in respect of the cultural heritage, may result in indiscriminate development, as witnessed at Apollonia, where a harbour was being built near the site, obliterating the ancient port. The paper discussed also the Project's proposal presented to the local authorities, concerning the realization of an archaeological park and museum of the history of Benghazi. These projects are important not only to attract tourists, but above all for the local schools and educational programmes directed to inform the younger generations about the importance of their past.

This article examines the role of source credibility in the sphere of wildlife conservation campaigns. Specifically, it explores how particular messengers can motivate hunters, ranchers, and wildlife managers in California, Utah, and Arizona to voluntarily adopt non-lead ammunition. I analyze two partner websites, each designed to provide the hunting community with accurate information about non-lead ammunition. I then identify key principles regarding source credibility that arose from semi-structured interviews with four individuals closely involved in North American vulture and raptor conservation: representatives of the Ventana Wildlife Society, the Institute for Wildlife Studies, The Peregrine Fund, and Pinnacles National Park. The conclusion identifies lessons about the role of source credibility in wildlife conservation campaigns and situates the findings in the context of existing research on environmental communication and education.

O artigo tem por objetivo discutir a relação entre futebol e política a partir do estudo do processo de tombamento da sede social do America Football Club (RJ). Mediante pesquisa sobre a história do clube, análise de reportagens da imprensa e do estudo da legislação, discutem-se os atos de tombamento da sede social, realizados no início da década de 2010, pela lavra discricionária do poder executivo municipal. Com base na teoria geral dos campos sociais de Bourdieu, buscou-se responder como e por que agentes políticos, provocados por dirigentes futebolísticos, apropriaram-se deste instrumento jurídico para, num primeiro momento proteger a edificação e, posteriormente, por outro decreto regulamentador, determinar o seu destombamento. Deste modo, possibilitou-se inferir ser o presente caso um inequívoco exemplo sobre os usos e abusos políticos do instituto do tombamento que, desvirtuado, não respondeu ao seu primordial interesse público, mas a interesses particulares.

La amenaza que representa la inseguridad pública en América Latina ha conllevado que muchos de los gobiernos asolados por ella recurran a las políticas de militarización. En el caso de México, el gobierno creó la Guardia Nacional para pacificar el país. El objetivo del artículo es responder la pregunta ¿por qué, pese a los argumentos y posturas de diferentes actores nacionales e internacionales, la Administración Federal en México (2018-2024) decidió crear una Guardia Nacional para combatir y reducir los índices de violencia? El estudio emplea un método explicativo y utiliza información del Banco Mundial, el Instituto Nacional de Estadística y Geografía (INEGI), el Fórum Brasileño de Seguridad Pública, World Prision Brief, el Índice de Paz Global, y el Secretariado Ejecutivo del Sistema Nacional de Seguridad Pública (SESNSP). La teoría de las políticas públicas en democracia permite explicar la importancia del desarrollo de esta última para comprender el diseño y los resultados de las primeras. Se toman como referencia los casos de Brasil y Colombia, países que han recurrido a estrategias de militarización (pero con resultados distintos), donde la variable ha sido el gasto militar. En ese ámbito, México está muy por debajo de los dos países aludidos. Abstract The threat posed by public insecurity in Latin America has led many of the governments affected by this problem to resort to militarization policies. In the case of Mexico, the government created the National Guard to pacify the country. The purpose of this article is to answer the question why, despite the arguments and positions of different national and international actors, the Federal Administration in Mexico (2018-2024) decided to create a National Guard to combat and reduce the rates of violence? The study uses an explanatory method and bases on information from the World Bank, the National Institute of Statistics and Geography (INEGI), the Brazilian Public Security Forum, the World Prision Brief, the Global Peace Index, and the Executive Secretariat of the National Public Security System (SESNSP). The theory of public policies in democracy allows to explain the importance of the development of the latter to understand the design and results of the former. The cases of Brazil and Colombia, countries that have resorted to militarization strategies (but with different results), where the variable has been military spending, are taken as reference. In that area, Mexico is well below the two countries mentioned.

Previous hematologic and serum biochemistry reference interval (RI) values have been established for donkeys in various geographic regions, life-stages, or for specific donkey breeds. The last extensive investigation establishing RIs for adult donkeys in the United States (U.S.) was published over three decades ago. We aimed to establish updated robust RIs using a reference population of apparently healthy adult donkeys from across the U.S. Standard sized (n = 102), miniature (n = 17), and mammoth (n = 1) donkeys from four different states were enrolled, with 20% of the study population including donkeys captured directly from the wild in Death Valley National Park, CA. RIs were established in accordance with the American Society for Veterinary Clinical Pathology and Clinical Laboratory Standards Institute guidelines. The findings will assist practitioners with the interpretation of their complete blood count and biochemistry panel results in U.S. donkeys. This study also highlights a comparison of results for some important analytes in U.S. donkeys compared to U.S. horses and previously established donkey RIs.

PurposeThe purpose of this contribution is to demonstrate the importance of interdisciplinary collaboration in integrating advanced and emerging digital techniques in the appropriate and sustainable documentation of heritage sites in Latin America. Existing collaboration between the Universidad del Externado de Colombia, the Colombian Institute of Anthropology and History and the Carleton Immersive Media Studio of Carleton University in Ottawa (Canada) have been sued to demonstrate the importance of this approach. The described collaboration allowed a team of students, researchers, government experts and educators to document selected pilot areas of the remarkable UNESCO World Heritage Sites of National Archeological Park of Tierradentro (UNESCO, 1995) and San Agustín Archaeological Park (UNESCO, 1995). The sophisticated digital recording techniques described, such as 3D scanning, aerial and ground photogrammetry techniques, were used to capture the site's current physical condition, emphasizing the pressing need to conserve the threatened mural paintings (Tierraadentro) and carved rock phases (San Agustin). This contribution also underlines the importance of developing the training of emerging professionals from Colombia in adopting these techniques to make their documentation more accurate, reliable and sustainable in the long term. The project's conclusions demonstrate that it is crucial to integrate emerging documentation techniques into the sustainable approach to conservation of these two important UNESCO World Heritage Sites.Design/methodology/approachThe approach presented in this contribution makes technology more accessible to the conservation specialist in Latin America. It provides a comprehensive capacity building program that involves teaching about theory and practice, using two important UNESCO World Heritage Sites located in Colombia. It is also relevant to the interdisciplinary and institutional collaboration between two universities in the North/South areas of the continent and a government institution that effectively collaborates to provide training to emerging professionals.FindingsThe contribution summarizes the opportunities and limitations of adopting technology to make the documentation process for conservation more sustainable in low-income economies and provides a framework to implement future strategies in South America.Originality/valueThe paper raises a discussion on how the concept of sustainability of adopting new technologies in the context of Latin American countries can assist in optimizing the conservation of decorated surfaces in important UNESCO World Heritage Sites by involving capacity building of emerging professionals.

The Institute of Transportation Engineers (ITE) guidelines serve as the most widely used reference for trip and parking generation estimates for any new development in the U.S.A. However, recent empirical studies question the efficacy of ITE guidelines in forecasting trip and parking generation in transit-oriented developments (TODs). Following the methodology of studies on seven TODs across the U.S.A., this study focuses on Dallas (TX), as a more auto-oriented American city, to explore the trip and parking generation at Mockingbird TOD. It finds that, with the exception of Station Park in Salt Lake City (which is really a transit-adjacent development rather than a TOD), the Mockingbird TOD has the lowest walk mode share (13.6%), the lowest bike mode share (0.22%), the lowest bus transit mode share (1.09%), and by far the lowest rail transit mode share (5.9%) of all the other seven TODs. Similarly, the Mockingbird TOD ranks first in relation to the driving mode share, with about 80% of its daily trips generated by driving. This is almost twice as many driving trips as the average of the other six TODs, which makes Mockingbird an auto-oriented TOD located in an auto-oriented region where more than 96% of commuting trips are by automobile. Still, the total automobile trip generation rate in Mockingbird is about 12% lower than the ITE estimates. Similarly, while the parking supply in Mockingbird TOD is less than 48% of the ITE recommended supply rate, its peak parking occupancy is only about 55% of the TOD supply.

To improve online learning pedagogy within the field of paralegal education, this study investigated how paralegal students and paralegal instructors perceived the effectiveness of synchronous and asynchronous online paralegal courses. This study intended to inform paralegal instructors and course developers how to better design, deliver, and evaluate effective online course instruction in the field of paralegal studies.Survey results were analyzed using independent samples t-test and correlational analysis, and indicated that overall, paralegal students and paralegal instructors positively perceived synchronous and asynchronous online paralegal courses. Paralegal instructors reported statistically significant higher perceptions than paralegal students: (1) of instructional design and course content in synchronous online paralegal courses; and (2) of technical assistance, communication, and course content in asynchronous online paralegal courses. Instructors also reported higher perceptions of the effectiveness of universal design, online instructional design, and course content in synchronous online paralegal courses than in asynchronous online paralegal courses. Paralegal students reported higher perceptions of asynchronous online paralegal course effectiveness regarding universal design than paralegal instructors. No statistically significant differences existed between paralegal students’ perceptions of the effectiveness of synchronous and asynchronous online paralegal courses. A strong, negative relationship existed between paralegal students’ age and their perceptions of effective synchronous paralegal courses, which were statistically and practically significant. Lastly, this study provided practical applicability and opportunities for future research. Akyol, Z., & Garrison, D. R. (2008). The development of a community of inquiry over time in an online course: Understanding the progression and integration of social, cognitive and teaching presence. Journal of Asynchronous Learning Networks, 12, 3-22. Retrieved from https://files.eric.ed.gov/fulltext/EJ837483.pdf Akyol, Z., Garrison, D. R., & Ozden, M. Y. (2009). Online and blended communities of inquiry: Exploring the developmental and perceptional differences. The International Review of Research in Open and Distributed Learning, 10(6), 65-83. Retrieved from http://www.irrodl.org/index.php/irrodl/article/view/765/1436 Allen, I. E., & Seaman, J. (2014). Grade change: Tracking online education in the United States. Babson Park, MA: Babson Survey Research Group and Quahog Research Group, LLC. Retrieved from https://www.utc.edu/learn/pdfs/online/sloanc-report-2014.pdf Alreck, P. L., & Settle, R. B. (2004). The Survey Research Handbook (3rd ed.) New York, NY: McGraw-Hill Irwin. American Association for Paralegal Education (2013, Oct.). AAfPE core competencies for paralegal programs. Retrieved from https://cdn.ymaws.com/www.aafpe.org/resource/resmgr/Docs/AAfPECoreCompetencies.pdf American Bar Association, Standing Committee on Paralegals. (2017). https://www.americanbar.org/groups/paralegals.html American Bar Association, Standing Committee on Paralegals (2013, September). Guidelines for the approval of paralegal education programs. Retrieved from https://www.americanbar.org/content/dam/aba/administrative/paralegals/ls_prlgs_2013_paralegal_guidelines.authcheckdam.pdf Astani, M., Ready, K. J., & Duplaga, E. A. (2010). Online course experience matters: Investigating students’ perceptions of online learning. Issues in Information Systems, 11(2), 14-21. Retrieved from http://iacis.org/iis/2010/14-21_LV2010_1526.pdf Bailey, C. J., & Card, K. A. (2009). Effective pedagogical practices for online teaching: Perception of experienced instructors. The Internet and Higher Education, 12, 152-155. doi: 10.1016/j.iheduc.2009.08.002 Bernard, R., Abrami, P., Borokhovski, E., Wade, C., Tamim , R., Surkes, M., & Bethel, E. (2009). A meta-analysis of three types of interaction treatments in distance education. Review of Educational Research, 79, 1243-1289. doi: 10.3102/0034654309333844 Cherry, S. J., & Flora, B. H. (2017). Radiography faculty engaged in online education: Perceptions of effectiveness, satisfaction, and technological self-efficacy. Radiologic Technology, 88(3), 249-262. http://www.radiologictechnology.org/ Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). New York: Taylor & Francis Group. Colorado, J. T., & Eberle, J. (2010). Student demographics and success in online learning environments. Emporia State Research Studies, 46(1), 4-10. Retrieved from https://esirc.emporia.edu/bitstream/handle/123456789/380/205.2.pdf?sequence=1 Dutcher, C. W., Epps, K. K., & Cleaveland, M. C. (2015). Comparing business law in online and face to face formats: A difference in student learning perception. Academy of Educational Leadership Journal, 19, 123-134. http://www.abacademies.org/journals/academy-of-educational-leadership-journal-home.html Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39, 175-191. Retrieved from http://www.gpower.hhu.de/fileadmin/redaktion/Fakultaeten/Mathematisch-Naturwissenschaftliche_Fakultaet/Psychologie/AAP/gpower/GPower3-BRM-Paper.pdf Field, A. (2009). Discovery statistics using SPSS. (3rd ed.). Thousand Oaks, CA: Sage Publications, Inc. Gall M., Borg, W., & Gall, J. (1996). Educational research: An introduction (6th ed.). White Plains, NY: Longman Press. Garrison, D. R., Anderson, T., & Archer, W. (2001). Critical thinking, cognitive presence, and computer conferencing in distance education. American Journal of distance education, 15(1), 7-23. Retrieved from http://cde.athabascau.ca/coi_site/documents/Garrison_Anderson_Archer_CogPres_Final.pdf Green, S. B., & Salkind, N. J. (2005). Using SPSS for Windows and Macintosh: Internal consistency estimates of reliability. Upper Saddle River, NJ: Pearson Prentice Hall. Harrell, I. L. (2008). Increasing the Success of Online Students. Inquiry, 13(1), 36-44. Retrieved from http://files.eric.ed.gov/fulltext/EJ833911.pdf Horspool, A., & Lange, C. (2012). Applying the scholarship of teaching and learning: student perceptions, behaviours and success online and face-to-face. Assessment & Evaluation in Higher Education, 37, 73-88. doi: 10.1080/02602938.2010.496532 Inman, E., Kerwin, M., & Mayes, L. (1999). Instructor and student attitudes toward distance learning. Community College Journal of Research & Practice, 23, 581-591. doi:10.1080/106689299264594 Institute of Legal Executives (ILEX). https://www.cilexcareers.org.uk/ Johnson, J. & Taggart, G. (1996). Computer assisted instruction in paralegal education: Does it help? Journal of Paralegal Education and Practice, 12, 1-21. Johnstone, Q. & Flood, J. (1982). Paralegals in English and American law offices. Windsor YB Access to Justice 2, 152. Jones, S. J. (2012). Reading between the lines of online course evaluations: Identifiable actions that improve student perceptions of teaching effectiveness and course value. Journal of Asynchronous Learning Networks, 16(1), 49-58. doi:http://dx.doi.org/10.24059/olj.v16i1.227 Krejcie, R. V., & Morgan, D. W. (1970). Determining sample size for research activities. Educational and psychological measurement, 30, 607-610. http://journals.sagepub.com/home/epm Liu, S., Gomez, J., Khan, B., & Yen, C. J. (2007). Toward a learner-oriented community college online course dropout framework. International Journal on ELearning, 6(4), 519-542. https://www.learntechlib.org/j/IJEL/ Lloyd, S. A., Byrne, M. M., & McCoy, T. S. (2012). Faculty-perceived barriers of online education. Journal of online learning and teaching, 8(1), 1-12. Retrieved from http://jolt.merlot.org/vol8no1/lloyd_0312.pdf Lockee, B., Burton, J., & Potter, K. (2010, March). Organizational perspectives on quality in distance learning. In D. Gibson & B. Dodge (Eds.), Proceedings of SITE 2010—Society for Information Technology & Teacher Education International Conference (pp. 659-664). San Diego, CA: Association for the Advancement of Computing in Education (AACE). https://www.learntechlib.org/p/33419/ Lowerison, G., Sclater, J., Schmid, R. F., & Abrami, P. C. (2006). Student perceived effectiveness of computer technology use in post-secondary classrooms. Computers & Education, 47(4), 465-489. doi:10.1016/j.compedu.2004.10.014 Retrieved from https://pdfs.semanticscholar.org/fc9c/13f0187d3967217aa82cc96c188427e29ec9.pdf Martins, L. L., & Kellermanns, F. W. (2004). A model of business school students' acceptance of a web-based course management system. Academy of Management Learning & Education, 3(1), 7-26. doi: 10.5465/AMLE.2004.12436815 Mayes, J. T. (2001). Quality in an e-University. Assessment & Evaluation in Higher Education, 26, 465-473. doi:10.1080/02602930120082032 McCabe, S. (2007). A brief history of the paralegal profession. Michigan Bar Journal, 86(7), 18-21. Retrieved from https://www.michbar.org/file/barjournal/article/documents/pdf4article1177.pdf McMillan, J. H. (2008). Educational Research: Fundamentals for the customer. Boston, MA: Pearson Education, Inc. Myers, C. B., Bennett, D., Brown, G., & Henderson, T. (2004). Emerging online learning environments and student learning: An analysis of faculty perceptions. Educational Technology & Society, 7(1), 78-86. Retrieved from http://www.ifets.info/journals/7_1/9.pdf Myers, K. (2002). Distance education: A primer. Journal of Paralegal Education & Practice, 18, 57-64. Nunnaly, J. (1978). Psychometric theory. New York: McGraw-Hill. Otter, R. R., Seipel, S., Graeff, T., Alexander, B., Boraiko, C., Gray, J., Petersen, K., & Sadler, K. (2013). Comparing student and faculty perceptions of online and traditional courses. The Internet and Higher Education, 19, 27-35. doi:10.1016/j.iheduc.2013.08.001 Popham, W. J. (2000). Modern educational measurement: Practical guidelines for educational leaders. Boston, MA: Allyn & Bacon. Rich, A. J., & Dereshiwsky, M. I. (2011). Assessing the comparative effectiveness of teaching undergraduate intermediate accounting in the online classroom format. Journal of College Teaching and Learning, 8(9), 19. https://www.cluteinstitute.com/ojs/index.php/TLC/ Robinson, C., & Hullinger, H. (2008). New benchmarks in higher education: Student engagement in online learning. The Journal of Education for Business, 84(2), 101-109. Retrieved from http://anitacrawley.net/Resources/Articles/New%20Benchmarks%20in%20Higher%20Education.pdf Salkind, N. J. (2008). Statistics for people who think they hate statistics. Los Angeles, CA: Sage Publications. Santos, J. (1999, April). Cronbach's Alpha: A tool for assessing the reliability of scales. Journal of Extension, 37, 2. Retrieved from https://www.joe.org/joe/1999april/tt3.php Seok, S., DaCosta, B., Kinsell, C., & Tung, C. K. (2010). Comparison of instructors' and students' perceptions of the effectiveness of online courses. Quarterly Review of Distance Education, 11(1), 25. Retrieved from http://online.nuc.edu/ctl_en/wp-content/uploads/2015/08/Online-education-effectiviness.pdf Sheridan, K., & Kelly, M. A. (2010). The indicators of instructor presence that are important to students in online courses. Journal of Online Learning and Teaching, 6(4), 767-779. Retrieved from http://jolt.merlot.org/vol6no4/sheridan_1210.pdf Shook, B. L., Greer, M. J., & Campbell, S. (2013). Student perceptions of online instruction. International Journal of Arts & Sciences, 6(4), 337. Retrieved from https://s3.amazonaws.com/academia.edu.documents/34496977/Ophoff.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1508119686&Signature=J1lJ8VO0xardd%2FwH35pGj14UeBg%3D&response-content-disposition=inline%3B%20filename%3DStudent_Perceptions_of_Online_Learning.pdf Song, L., Singleton, E. S., Hill, J. R., & Koh, M. H. (2004). Improving online learning: Student perceptions of useful and challenging characteristics. The Internet and Higher Education, 7, 59-70. doi:10.1016/j.iheduc.2003.11.003 Steiner, S. D., & Hyman, M. R. (2010). Improving the student experience: Allowing students enrolled in a required course to select online or face-to-face instruction. Marketing Education Review, 20, 29-34. doi:10.2753/MER1052-8008200105 Stoel, L., & Hye Lee, K. (2003). Modeling the effect of experience on student acceptance of web-based courseware. Internet Research, 13(5), 364-374. http://www.emeraldinsight.com/loi/intr Taggart, G., & Bodle, J. H. (2003). Example of assessment of student outcomes data from on-line paralegal courses: Lessons learned. Journal of Paralegal Education & Practice, 19, 29-36. Tanner, J. R., Noser, T. C., & Totaro, M. W. (2009). Business faculty and undergraduate students' perceptions of online learning: A comparative study. Journal of Information Systems Education, 20, 29-40. http://jise.org/ Tung, C.K. (2007). Perceptions of students and instructors of online and web-enhanced course effectiveness in community colleges (Doctoral dissertation). Retrieved from ProQuest Dissertations and Theses database (Publication No. AAT 3284232). Vodanovich, S. J. & Piotrowski, C., & (2000). Are the reported barriers to Internet-based instruction warranted? A synthesis of recent research. Education, 121(1), 48-53. http://www.projectinnovation.com/education.html Ward, M. E., Peters, G., & Shelley, K. (2010). Student and faculty perceptions of the quality of online learning experiences. The International Review of Research in Open and Distributed Learning, 11, 57-77. Retrieved from http://www.irrodl.org/index.php/irrodl/article/view/867/1610? Wilkes, R. B., Simon, J. C., & Brooks, L. D. (2006). A comparison of faculty and undergraduate students' perceptions of online courses and degree programs. Journal of Information Systems Education, 17, 131-140. http://jise.org/

This study aimed to evaluate the in vitro antifungal susceptibility of Candida species of head-and-neck-irradiated patients (Group 1), non-institutionalized (Group 2) and institutionalized elders (Group 3) using Etest(r) methodology. Candida was isolated from saliva and presumptively identified by CHROMagar Candida(r), confirmed by morphological criteria, carbohydrate assimilation (API 20C AUX(r)) and genetic typing (OPE 18). The collection was made from 29, 34 and 29 individuals (Groups 1, 2 and 3, respectively) with 67 isolates. Etest(r) strips (ketoconazole, itraconazole, fluconazole, amphotericin B and flucytosine) on RPMI (Roswell Park Memorial Institute) agar, on duplicate, were used to evaluate susceptibility. ATTC (American Type Culture Collection) 10231 (Candida albicans) was used as quality control. Among the 67 isolates of Candida species, most were susceptible to azoles, flucytosine and amphotericin B. None of the isolates showed resistance and dose-dependent susceptibility to amphotericin B. There were nine strains resistant to itraconazole, six to fluconazole and two to ketoconazole and ten dose-dependent, mainly to flucytocine. The highest MIC (minimum inhibitory concentration) to C. albicans, C. tropicalis, C. parapsilosis was 2.671 μg.mL-1, 8.104 μg.mL-1, 4.429 μg.mL-1, all for flucytosine. C. krusei and C. glabrata were associated with higher MIC for azoles and C. glabrata with higher MIC to flucytosine. In summary, susceptibility to all tested antifungal agents was evident. The isolates were more resistant to itraconazole and dose-dependent to flucytosine. A comparison of C. albicans in the three groups showed no outliers. Higher MIC was associated with C. krusei and C. glabrata.

Background Accumulating evidence shows that subtle alterations in daily functioning are among the earliest and strongest signals that predict cognitive decline and dementia. A survey is a small slice of everyday functioning; nevertheless, completing a survey is a complex and cognitively demanding task that requires attention, working memory, executive functioning, and short- and long-term memory. Examining older people’s survey response behaviors, which focus on how respondents complete surveys irrespective of the content being sought by the questions, may represent a valuable but often neglected resource that can be leveraged to develop behavior-based early markers of cognitive decline and dementia that are cost-effective, unobtrusive, and scalable for use in large population samples. Objective This paper describes the protocol of a multiyear research project funded by the US National Institute on Aging to develop early markers of cognitive decline and dementia derived from survey response behaviors at older ages. Methods Two types of indices summarizing different aspects of older adults’ survey response behaviors are created. Indices of subtle reporting mistakes are derived from questionnaire answer patterns in a number of population-based longitudinal aging studies. In parallel, para-data indices are generated from computer use behaviors recorded on the backend server of a large web-based panel study known as the Understanding America Study (UAS). In-depth examinations of the properties of the created questionnaire answer pattern and para-data indices will be conducted for the purpose of evaluating their concurrent validity, sensitivity to change, and predictive validity. We will synthesize the indices using individual participant data meta-analysis and conduct feature selection to identify the optimal combination of indices for predicting cognitive decline and dementia. Results As of October 2022, we have identified 15 longitudinal ageing studies as eligible data sources for creating questionnaire answer pattern indices and obtained para-data from 15 UAS surveys that were fielded from mid-2014 to 2015. A total of 20 questionnaire answer pattern indices and 20 para-data indices have also been identified. We have conducted a preliminary investigation to test the utility of the questionnaire answer patterns and para-data indices for the prediction of cognitive decline and dementia. These early results are based on only a subset of indices but are suggestive of the findings that we anticipate will emerge from the planned analyses of multiple behavioral indices derived from many diverse studies. Conclusions Survey response behaviors are a relatively inexpensive data source, but they are seldom used directly for epidemiological research on cognitive impairment at older ages. This study is anticipated to develop an innovative yet unconventional approach that may complement existing approaches aimed at the early detection of cognitive decline and dementia. International Registered Report Identifier (IRRID) DERR1-10.2196/44627

17509 Background: t-MDS is well described following treatment of lymphomas, solid tumors and acute promyelocytic leukemia. In contrast, it has been reported only rarely following treatment of AML, possibly because of the smaller percentage of long-term survivors or the difficulty of distinguishing t-MDS from AML relapse. Methods: Roswell Park Cancer Institute (RPCI) patients with a diagnosis of MDS by French-American-British or World Health Organization criteria following a diagnosis of AML were retrospectively reviewed. Results: Five adult patients treated for de novo AML between 1996 and 2005 developed MDS, representing less than 1% of 548 RPCI AML patients during those years. MDS presented as cytopenias and marrow dysplasia, occurred 11 to 101 (median 27) months after diagnosis of de novo AML, and was associated with chromosome 7 abnormalities, including monosomy 7 or del(7q), in all five. All had been treated with cytarabine and topoisomerase II inhibitors and three had received alkylating agents as part of autologous transplant regimens. All had received granulocyte colony-stimulating factor or granulocyte-monocyte colony-stimulating factor in conjunction with chemotherapy and/or autologous transplantation. Fluorescence in situ hybridization with the CEP 7 probe or the dual-color LSI D7S486 (7q31)/CEP 7 probe set did not demonstrate chromosome 7 abnormalities in marrow prior to MDS diagnosis nor in peripheral blood stem cells of patients who had undergone autologous transplantation prior to diagnosis of MDS. MDS has progressed slowly in all patients; it evolved to AML in two following 18 and 24 months. Conclusions: These cases further document t-MDS following AML therapy. Presence of chromosome 7 abnormalities in cases without, as well as with, prior alkylating agent therapy suggests possible association with the anti-metabolite cytarabine. No significant financial relationships to disclose.

17506 Background: Therapy-related AML (t-AML) has been reported in ovarian cancer patients treated with chemotherapy and has been associated with the use of platinum. However, little is known about these patients’ clinical characteristics, cytogenetic changes, clinical course or treatment outcome. Methods: Roswell Park Cancer Institute patients with diagnoses of AML or MDS by French-American- British (FAB) Group or World Health Organization criteria following a diagnosis of ovarian cancer were retrospectively reviewed. Results: Ten patients were identified between 1990 and 2006. All 10 had received platinum chemotherapy, and 8 (80%) had also received taxanes, 4 (40%) cyclophosphamide and 3 (30%) adriamycin. The median age at ovarian cancer diagnosis was 56 (range, 49–78) years, and the median age at AML/MDS diagnosis was 62 (range, 56–81) years. The median interval from diagnosis of ovarian cancer to AML/MDS was 5.5 (range, 3–11) years, while the median survival time of 395 ovarian cancer patients treated at RPCI between 1982 and 1998 was 4.1 years (range, 1 month to 23 years). Eight patients had AML and 2 had MDS. AML FAB types were M2 in 3, M0 and M4 in 2 each, and M6 in 1. Among 9 patients with cytogenetic data available, 6 had complex karyotypes, all of which included monosomy 5 or del(5q), and three had single clonal abnormalities, all involving chromosome 7. Of 7 AML patients who received induction chemotherapy, only 3 achieved complete remissions, and remissions were brief (3, 4.5 and 5 months). Median overall survival for all ten patients after diagnosis of AML or MDS was 4 months (range, 0.5 months to 9.5 months). Conclusions: Patients with t-AML/t-MDS following therapy for ovarian cancer have unfavorable cytogenetic abnormalities, including complex karyotypes and involvement of chromosomes 5 and 7, which are typical findings following alkylating agent therapy, and these patients have a very poor prognosis. No significant financial relationships to disclose.

7051 Background: Increasing use of chemotherapy and radiation therapy in breast cancer patients in the adjuvant setting heightens concern about therapy-related AML and MDS. Little is known about the characteristics of these disorders following breast cancer. Methods: Roswell Park Cancer Institute (RPCI) patients with diagnoses of MDS or AML by French-American-British Group or World Health Organization criteria following breast cancer were retrospectively reviewed. Results: 34 women were identified between 1983 and 2006. 10 (29%) were also diagnosed with additional malignancies, including non-Hodgkin lymphoma (NHL), bladder, colon, lung, uterine and thyroid cancers, Ewing sarcoma and angiosarcoma. 23 of 31 patients (74%) with family histories documented had first-degree relatives with cancers, including breast, lung, colon, stomach, pancreas, prostate, renal, melanoma, esophagus, thyroid, Hodgkin lymphoma and leukemia, compared to a 45% prevalence of first-degree relatives with cancer among 1982 control RPCI breast cancer patients (p= 0.001). Median age at breast cancer diagnosis was 58 (range, 37–85) years. Among the 29 patients with known treatment, 25 (86%) had received radiation therapy, 13 (45%) had received chemotherapy, including alkylating agents in all 13 (45%) and topoisomerase II inhibitors in 8(28%), while 4 (14%) had received no adjuvant therapy. Median age at AML/MDS diagnosis was 70 (range, 46–90) years. 26 patients had AML and 8 MDS, of whom 4 progressed to AML. Karyotypes were complex in 10 (29%), involved 11q23 rearrangements in 6 (18%), were favorable, normal and unknown in 5 each (45%), and had miscellaneous single structural abnormalities in 3 (9%); they did not strictly correlate with treatment received. Median survival (months) was 1 for complex karyotype, 6 for 11q23 translocation and 40 for favorable karyotype patients. Conclusions: The incidence of other cancers and of cancers in family members was unexpectedly high in breast cancer patients with AML and MDS, in the absence of known genetic syndromes, suggesting genetic polymorphisms predisposing to multiple cancers. Cytogenetic abnormalities included complex, 11q23 and favorable karyotypes, and survival reflected karyotypes. No significant financial relationships to disclose.

10582 Background: The American Institute for Cancer Research and American Cancer Society regularly publish cancer prevention recommendations for decreasing cancer risk. Which lifestyles, or whether they work together to impact cancer survival is not well established. We examined associations of adherence to cancer prevention recommendations with mortality in 5,766 patients enrolled in the Data Bank and BioRepository at Roswell Park. Methods: Patients were newly diagnosed between 2003 and 2016 with a variety of pathologically confirmed invasive malignancies. Detailed epidemiological data including lifestyles one year prior to diagnosis were linked with Tumor Registry data. The primary analytic exposure was a composite Lifestyle Index Score (LIS) created in accordance with previously published standardization guidance; the primary analytic outcome was all-cause mortality. The LIS comprised seven lifestyles including: physical activity (PA); body mass index (BMI); fruit and vegetable (FV) intake; red and processed meat (RPM) intake; sugar sweetened beverage (SSB) consumption; alcohol consumption; and smoking status. Kaplan Meier analyses were used to compare survival experience according to LIS tertiles. Multivariable Cox proportional hazard models adjusted for age, tumor type, stage, and sex were used to estimate the associations of the LIS and each lifestyle factor with mortality in the overall study population and according to tumor stage. Results: During follow-up through April 2022, we observed 2,316 deaths (median follow-up 6.9 years). Patients reporting strongest adherence to prevention recommendations (highest LIS tertile) had significantly improved survival compared to patients with the lowest LIS (93.0 vs. 75.0 months, respectively; log-rank p < 0.0001). In multivariable analyses, the highest versus lowest LIS tertile was associated with a 17% reduction in mortality in the overall study population (HR = 0.83, 95% CI: 0.74-0.93). Significant mortality reductions were observed in patients diagnosed with both early- and late-stage disease (HR = 0.73, 95% CI: 0.59-0.90 and HR = 0.85, 95% CI: 0.73-0.99, respectively). Being a never smoker (HR = 0.54, 95% CI: 0.47-0.62), meeting the PA Guidelines (HR = 0.74, 95% CI: 0.66-0.83), and highest FV intake (HR = 0.82, 95% CI: 0.73-0.91) were the only independent factors associated with significant reductions in mortality. Conclusions: Strongest adherence to the cancer prevention recommendations before diagnosis was associated with significant reductions in mortality. These findings provide additional evidence that modifiable lifestyle factors can impact cancer survival, even among patients diagnosed with advanced-stage disease. Confirmatory studies examining post-diagnosis lifestyles are needed so that lifestyle assessment tools, education, and intervention can be clinically leveraged to improve patient outcomes.

Abstract Advanced lung cancer patients that present with activating mutations in the epidermal growth factor receptor (EGFR) are treated with EGFR tyrosine kinase inhibitors (EGFR TKIs). While initially effective, all patients eventually develop therapeutic resistance and experience disease progression. Strategies to prevent EGFR TKI resistance are needed to improve patient outcomes. We chronically exposed H1975 cells (EGFR-L858R/T790M) to EGFR TKI osimertinib to study emergence of resistance. H1975 cells that were expanded under drug treatment (designated H1975OR) acquired an EMT phenotype and were re-sensitized to EGFR TKI upon prolonged drug withdrawal. These features led us to classify H1975OR as a model of drug tolerance rather than a model of stable drug resistance. Bulk RNA-sequencing revealed significant dysregulation of chromatin modifying genes in H1975OR. Bromodomain containing protein 9 (BRD9) was among the set of significantly upregulated chromatin regulators and was selected for further investigation as a mediator of drug tolerance. Although BRD9 is known to control stemness and EMT, its role in promoting EMT-associated TKI resistance is unknown. To test the contribution of BRD9 to EGFR TKI tolerance, pharmacological inhibition of BRD9 by the selective inhibitor, I-BRD9 significantly increased sensitivity to TKI in models with EMT phenotypes (IC50 reduced 3-4 fold). In contrast, I-BRD9 did not affect TKI sensitivity in two models where EGFR TKI resistance was genetically fixed. To gain mechanistic insights, H1975OR cells were treated with osimertinib +/-I-BRD9 and subjected to RNA-sequencing. Combination of osimertinib with I-BRD9 resulted in a significant decrease in EMT-related genes, including MMP9, Zeb2, PDGFRb and IL6. Further, use of I-BRD9 in these models diminished the mesenchymal phenotype, as measured in cell invasion assays. Genetic knockdown of BRD9 via shRNA phenocopied effects of I-BRD9 treatment, supporting BRD9 as the therapeutic target of I-BRD9 in our cell line models. To further establish a role for BRD9 in the emergence of drug tolerant cells, we exposed treatment naïve H1975 cells to EGFR TKI ± I-BRD9. I-BRD9 significantly decreased the size of the EGFR TKI tolerant population. In time course studies, I-BRD9 also delayed onset of TKI resistance. In conclusion, our data identifies BRD9 as a novel mediator of EMT-associated EGFR-TKI tolerance in EGFR-mutant lung cancer. Our data further implicates BRD9 inhibition as a novel strategy to delay the emergence of drug tolerant cells that eventually give rise to stable drug resistance. This work was supported by the Roswell Park Alliance Foundation and National Cancer Institute (NCI) grant P30CA016056 involving the use of Roswell Park Comprehensive Cancer Center’s Genomics and Bioinformatics Shared Resources. Citation Format: Hannah Calkins, Tatiana Shaurova, David W. Goodrich, Mukund Seshadri, Candace S. Johnson, Pamela A. Hershberger. BRD9 inhibition overcomes epithelial to mesenchymal transition (EMT)-associated tyrosine kinase inhibitor (TKI) tolerance in epidermal growth factor receptor (EGFR) mutant lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1093.

Abstract Background: AST-021p, which is derived from HLA class II binding epitopes of human HSP90 protein, is an investigational therapeutic cancer vaccine for the malignant neoplasms. AST-021p is designed to demonstrate the immunologic efficacy by activating antigen-specific CD4+ Th1 cell in humans. Due to their ability to link the innate with the adaptive immune response, Toll-like receptor (TLR) agonists are highly promising as adjuvants in vaccines against life-threatening and complex diseases such as cancer, AIDS and malaria. In this study, AST-021p was investigated to evaluate the immunogenicity and tumor growth inhibitory effect under the condition of combining with various immune adjuvants derived from TLR agonists, using in-vivo model. Methods: Three different agonists of TLR (TLR-4, TLR-2/3, TLR-7/8) were assigned to investigate the immunogenicity in each group (4 FVB/N mice/group, total 4 groups). AST-021p was intradermally injected 3 times with different TLR-agonists and the immunogenicity was assessed from mouse splenocyte by HSP90-specific IFN-γ ELISpot method. We also examined the efficacy of AST-021p and selected TLR-agonist in MMTV/neu Tg mice (4 mice/group, conducted twice and A total 8 mice was assigned to each group). The combination of AST-021p and TLR-2/3 agonist (AST-021p plus TLR-2/3 agonist) was injected 3 times every 10 days to mice followed by inoculated mouse mammary cancer cell line. The tumor volume change and immunogenicity were evaluated. Results: The most effective TLR-agonist as a potent immune adjuvant was a TLR-2/3 agonist (L-pampoTM, supplied by CHA Vaccine Institute). AST-021p (100 μg) plus TLR-2/3 agonist significantly improved immunogenicity by increasing HSP-90 epitope-specific T cells up to 130±10 per 1x105 spleen cell of FVB/N mice (P&lt;0.001). AST-021p plus TLR-2/3 agonist also showed higher tumor growth inhibitory effect (170±108 mm3) on post-implantation 35th day by suppressing mouse mammary cancer cell line (5x105)-derived tumor growth, compared with a TLR-2/3 agonist alone (1031±450 mm3). Conclusions: Combination regimen of AST-021p and TLR-2/3 agonist (as immune adjuvant) demonstrated significant immunogenicity and tumor prevention effect in in-vivo study. These data supported the clinical study of AST-021p combined with TLR-2/3 agonist as active immune adjuvant in certain tumor types, and phase 1/2 clinical program would be expected to be initiated. Citation Format: JinHo Kang, Jee Hyun Choi, Min Ji Seo, Eunjung Jung, Byung cheol Ahn, Jinback Lim, Hyo-Hyun Park, Hyunwon Shin, Eunkyo Joung, Hun Jung, Kyong Hwa Park. The anti-tumor activity of HSP-90 therapeutic cancer vaccine (AST-021p) combine with TLR2/3 agonist in a MMTV-neu transgenic model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6331.

Este artigo tem como objetivo analisar o processo de implementação do Programa Mais Educação na rede municipal pública de Dourados-MS, no período compreendido entre 2009 e 2015, com vistas a identificar e discutir a concepção de educação de tempo integral explicitada nesse processo. Para tanto, realizou-se pesquisa qualitativa, tendo como campo empírico as 45 escolas públicas municipais de Dourados – MS, utilizando como instrumento de coleta de dados questionário junto aos integrantes do Programa. Constata-se que a concepção de educação integral presente no Programa Mais Educação está relacionada à ampliação da jornada escolar; consequentemente, tal concepção está em consonância com a proposta preconizada pelo Programa que considera como educação integral, além de outros fatores, a jornada escolar com duração igual ou superior a sete horas diárias.REFERÊNCIASARROYO, M. O direito a tempos-espaços de um justo e digno viver. In MOLL, J. et al. Caminhos da Educação Integral no Brasil: direito a outros tempos e espaços educativos. Porto Alegre: Penso, 2012.BRASIL. Portaria Normativa Interministerial n° 17, de 24 de abril de 2007. Institui o Programa Mais Educação que visa fomentar a educação integral de crianças, adolescentes e jovens, por meio do apoio a atividades sócio-educativas no contraturno escolar. Diário Oficial da União, Brasília, DF, 26 abr. 2007a._______. Constituição (1988). Constituição da República Federativa do Brasil. Brasília: Senado Federal, 1998.________ Decreto nº 7.083, de 27 de janeiro de 2010. Institucionaliza o Programa Mais Educação. Brasília, DF, 2010a.________. Lei n º 9.394, de 20 de dezembro de 1996. Estabelece as diretrizes e bases da educação nacional. Brasília: Diário Oficial da República Federativa do Brasil, Poder Executivo, 23 dez. 1996._______. Lei nº 10.172 de 9 de janeiro de 2001. Aprova o Plano Nacional de Educação e dá outras providências. Brasília: Diário Oficial da República Federativa do Brasil, Poder Executivo, 9 de janeiro de 2001. Obtido em [https://www.planalto.gov.br/ccivil_03/leis/leis_2001/l10172.htm]. Acesso em 29 de dezembro de 2016.________. Manual de Educação Integral para Obtenção de Apoio Financeiro através do Programa Dinheiro Direto na Escola – PDDE/Integral, no exercício de 2008. Brasília, DF.________. Manual de Educação Integral para Obtenção de Apoio Financeiro através do Programa Dinheiro Direto na Escola – PDDE/Integral, no exercício de 2009 Brasília, DF, 2009a.________. Estatuto da Criança e do Adolescente: promulgado em 13 de julho de 1990. 9ª Ed. São Paulo: Saraiva, 1999b.________. Manual de Educação Integral para Obtenção de Apoio Financeiro através do Programa Dinheiro Direto na Escola – PDDE/Integral, no exercício de 2013 a. Brasília, DF.________. Programa Mais Educação: passo a passo. Brasília: MEC, Secad. 2009b. Disponível em http://portal.mec.gov.br/dmdocuments/passoapasso_maiseducacao.pdf. Acesso em 21 de junho de 2015.CAVALARI, R. M. F. Integralismo – ideologia e organização de um partido de massa no Brasil (1932-1937). Bauru: EDUSC, 1999. 239 p.CAVALIERE, A.M. Escolas de tempo integral versus alunos em tempo integral. Em Aberto, v.21, p. 51-63, 2009.CARVALHO, L. M. As políticas públicas de educação sob o prisma da ação pública: esboço de uma perspectiva de análise e inventário de estudos. Currículo sem fronteiras. V. 15, n.2, p.314-333, maio/ago. 2015.COELHO, L.M. da C. História (s) de educação integral. In: MAURÍCIO, L. V. (org).: Educação Integral em Tempo Integral. Em Aberto, Brasília, v. 22, n° 80, 2009. p. 83-96.CEPAL. Comissão Economica Para a America Latina e Caribe. Equidad, desarrollo y ciudadanía. México, DF: CEPAL, 2000.DOURADO, L. F; OLIVEIRA, J. F. A qualidade da educação; perspectivas e desafios. Cadernos Cedes. Campinas vol. 29, n. 78, maio/ago. 2009.DOURADOS. Secretaria Municipal de Educação. Relatório de Avaliação do Programa Mais Educação. Dourados: SEMED, 2014.GADOTTI, M. Educação integral no Brasil: inovações em processo. São Paulo: Instituto Paulo Freire, 2009.LECLERC, G. F. E.; MOLL, J. Programa Mais Educação: avanços e desafios para uma estratégia indutora da Educação Integral e em tempo integral. Educar em Revista. Curitiba. nº. 45, p. 91-110, jul./set. 2012.MONTEIRO, E. S. A implementação do Programa Mais Educação no município de Dourados-MS: concepções e práticas. Dourados, MS: Universidade Federal da Grande Dourados, 2016. (Dissertação de Mestrado).O PROGRESSO. Cidade de Dourados (MS) universaliza a educação em tempo integral. 28 de Abril, 2014.PARO, V. Educação integral em tempo integral: uma concepção de educação para a Modernidade. In: COELHO, Lígia Martha C. da Costa (Org.). Educação integral em tempo integral: estudos e experiências em processo. Petrópolis, RJ: FAPERJ, 2009.RODRIGUES, C. M. L.; VIANA, L. R.; BERNARDES, J. A. O Programa Mais Educação: breve análise do contexto político e dos pressupostos teóricos. Cadernos ANPAE, v. 17, p. 1-16, 2013.ROSA, V. S. O Programa Mais Educação como Política Pública Nacional de Educação Integral. In: IX ANPEd SUL Seminário de Pesquisa em Educação da Região Sul, 2012, Caxias do Sul, RS. Anais: ANPEd SUL, 2012.TEIXEIRA, A. Centro Educacional Carneiro Ribeiro. Revista Brasileira de Estudos Pedagógicos. Rio de Janeiro, v.31, n.73, jan./mar. 1959. p. 78-84. Disponível em: http://www.bvanisioteixeira.ufba.br/produde.htm. Acesso em: 17 jul. 2015.UNESCO. Boletin. Proyecto principal de educacion em America Latina y Caribe. Santiago UNESCO, 1996.Recebido em 11-04-2018 e aceito em 28-08-2018.

Abstract Abstract 4218 Introduction: Data recently published showed that besides the several well-known parameters, long term outcome after allogeneic stem cell transplantation (SCT) in chronic lymphocytic leukemia (CLL) may be influenced by the presence or absence of certain HLA class I alleles (HLA-A1+/A2-/B44-) (Khouri et. Al. Cancer 2011). We have also recently published an 11-year progression free survival (PFS) rate of 72% in relapsed follicular lymphoma (FL) after SCT (Khouri et al. Blood 2012). A higher relapse rate has been observed in CLL patients when compared to FL (50% vs. 4%). Since HLA subtypes played an important role in CLL, our goal in this study was to assess and compare over expressed HLA alleles in FL and CLL patients who received a SCT at our center. Methods: Two cohorts of patients who received SCT were retrospectively studied. Group I consisted of 59 Caucasian patients (23 [39%] F: 36 [61%] M) with FL and Group II consisted of 119 Caucasian patients (27 [23%] F: 112 [77%] M) with CLL. The HLA alleles at HLA-A, -B,-C and -DRB1 loci of both groups were analyzed and the HLA typing was performed by polymerase chain reaction (PCR) amplification and oligonucleotide hybridization using commercial kits from Invitrogen (Carlsbad, Ca) or One Lambda (Canoga Park, Ca) that resulted in intermediate resolution. Patients were also typed for these loci using high-resolution methods with PCR amplification and nucleotide sequencing (Abbott, Abbott Park, Ill). The antigen frequencies of all of the alleles of HLA-A, -B,-C AND DRB1 were calculated. Antigen frequency was defined as the percentage of the population possessing the antigen. Antigen frequency comparisons were only done for North American whites due to sample size and control group constraints. The control group was based on a sample analysis of 643 normal North American Whites. The Pearson x2goodness-of-fit test was used to validate the Hardy-Weinberg genetic equilibrium for phenotypic data. The association of various alleles with the control group was determined by using a chi-square test with Yates correction in a 2 × 2 table with 1 degree of freedom (SAS software, version 6.12, SAS Institute Inc, Cary NC). P values < 0.05 at the 95% confidence interval (95% CI) were considered significant. Results: A male predominance was noted in both patient groups. A total of 17 HLA-A, 29 HLA-B, 13 HLA-C and 13 HLA-DRB1 distinct alleles for FL patients and 16 HLA-A, 24 HLA-B, 13 HLA-C and 11 HLA-DRB1 distinct alleles were identified for the CLL patients. Since the predominant ethnic type in both groups were North American Whites, statistically valid comparisons of HLA antigen frequencies were only possible in this population. The observed heterozygosity for FL/CLL patients was 0.93220./0.831932 for HLA-A, 0.915254/0.949579 for HLA-B, 0.779661/0.882352 for HLA-C and 0.847457/0.941176 for HLA-DRB1. There were no untyped patients and all of the patients underwent hematopoietic stem cell transplantation. Our analysis reveals an over expression of HLA-A*03, HLA-C*04, HLA-DRB1*01, HLA-DRB1*07 and HLA-DRB1*15 with frequencies of 25.4%, 24.1%, 22.9%, 28.8% and 8.5 % in FL patients which was significantly higher than the frequencies of 15.1% for HLA-A*03 (p value 0.005), 1.1% for HLA-C*04 (p value < .00001), 10.3% for HLA-DRB1*01 (p value <.0001), 14.4% for HLA-DRB1*07 (p value < .0001) and 15.7% for HLA-DRB1*15 (p value < .0495) in the normal population showing for the first time an over representation of these alleles in patients with FL. In the CLL group our analysis revealed a 24.8% (p value 0.0014) frequency for HLA-A*01 which was significantly higher than the frequency of 16% (p value 0.0014) in the normal population showing an overrepresentation of this allele. The underrepresented allele was HLA-B*38 with a frequency of 3.4% compared to 12.4% (p value 0.0335) in the normal population. When the two groups FL and CLL patients were analyzed, the significant alleles were HLA-A*01, HLA-A*03, HLA-C*04, HLA-DRB1*01 and HLA-DRB1*07. Conclusion: Our results demonstrate a significant difference in HLA expression in Follicular Lymphoma and Chronic Lymphocytic Leukemia patients with the over representation of HLA-A*03, HLA-C*04, HLA-DRB1*01, HLA-DRB1*07 and HLA-DRB1*15 alleles in FL and HLA-A*01 and HLA-B*38 alleles in CLL. We do not know whether these variances account for a different graft-versus-malignancy susceptibility to donor cells between the two groups and this remains to be studied. Disclosures: No relevant conflicts of interest to declare.

Abstract Background: The focus of this one-year collaborative initiative between the Center for Indigenous Cancer Research at Roswell Park and Northwestern University’s Institute of Sexual and Gender Minority Health and Wellbeing is to refine and customize an existing colorectal cancer (CRC) screening program to suit the unique needs of Two-Spirit and Native American LGBTQ+ urban populations. This undertaking, grounded in exploratory and explanatory qualitative methodologies, is not intended to test a predefined hypothesis, but rather aims to learn, understand, and adapt based on community input and participation. Methods: The project's methodology incorporates two main objectives: (Objective 1) Conducting virtual roundtables with representatives from the Two-Spirit and Native LGBTQ+ community in NYC, with the goal of understanding indigenous perspectives on CRC outreach and screening, and to garner insights on how to tailor these interventions for Native sexual and gender minority populations in urban settings; (Objective 2) Applying qualitative data gleaned from Objective 1 to modify NCI-endorsed materials, with the aim of more effectively conveying outreach and screening information to Two-Spirit and Native LGBTQ+ urban communities. Results: The initiative has engaged a Two-Spirit artist and educator to assist in the organization and co-facilitation of six virtual roundtable conversations, involving a total of 14 participants. Each 90-minute dialogue aimed to solicit input on current education materials, as well as suggestions for their adaptation. A team of five Northwestern University medical students collaborated on the project, contributing to the analysis of the collected qualitative data. Next Steps: Findings from this initiative will offer crucial insights into how the visuals, messaging, and information contained in the S2S colorectal cancer education materials can be revised to better engage Two-Spirit and Native LGBTQ+ individuals. By the project's conclusion, partners will possess clear, community-informed directives on how to adapt CRC outreach and screening resources, paving the way for future testing and implementation. Citation Format: Corinne E. Abrams. Advancing colorectal cancer outreach & screening strategies: Tailoring approaches for two-spirit and urban Native LGBTQIA2S+ populations [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A013.

Introduction: This chapter addresses chemical aspects of occupational health and marine oil-spill response and is restricted to exposures to crude oil in its various forms. Thus in-situ burning of oil is included, but ancillary chemicals such as surfactants or bioremediation agents are not. The content of this chapter is largely based on the literature published after 1985, the date of a comprehensive review conducted by Politzer et al. [1985] for the American Petroleum Institute, and on a review carried out for the Marine Spill Response Corporation early in 1993 [Holliday and Park, 1993].Concern about health and safety is a normal part of every oil spill. In general, safety is easier to understand and address than are concerns about exposure to crude oil and other chemicals which might be used in the response. At one level, human exposure can be addressed through the enforcement of very conservative requirements for the use of personal protective equipment (PPE). In the real world, however, conditions at a spill site make the use of such equipment inconvenient or even hazardous, and so the goal becomes to balance the risk from exposure with the appropriate level of PPE.While oil-spill cleanup is a comparatively new aspect of occupational-health practice, and dates from the formalization of response measures by companies and national and international agencies (something that occurred over the last 30 years), exposure to crude oil itself is a "mature" occupational-health matter. Workers have been exposed, both by inhalation and dermally, to the effects of crude oil for the past century. The exposure of response workers during the early phases of the oil-spill response can be likened to that experienced by oil-well-drilling crews and, to a lesser extent, by oil-well-maintenance personnel or fighters of oil-well fires. In contrast, exposures in the later stages of the cleanup are less clearly related to occupations within the oil industry. The crude oil will have been altered by weathering, and exposure to cleanup chemicals (e.g., dispersants, bioremediation agents) will become relatively more prominent. Such substances are beyond the scope of this chapter, and in any event, few data are available on the compositions or mammalian toxicity of dispersants. Although there are frequent references to toxicity in connection with dispersants, these invariably seem to refer to ecotoxicity. Human hazard does not appear to be an issue. For example, in a recently published paper entitled, "Effectiveness and safety of biosurfactants as agents of oil spill response" [Lepo et al., 1997], "safety" refers to possible toxicity to crustaceans and fish.

Abstract Introduction: Pancreatic cystic lesions (PCL) are common and a subset of mucinous cysts will transform into pancreatic ductal adenocarcinoma (PDAC). However, predicting which of these mucinous PCL may progress to PDAC and warrant surgery remains a clinical challenge. Moreover, identifying those clinically emergent mucinous PCL for which a surveillance approach is best is a dire clinical need. Therefore, we aimed to identify molecular signatures that distinguished between PDAC with and without clinical evidence of a PCL to identify novel biomarkers. Methods: We leveraged data from the Oncology Research Information Exchange Network (ORIEN) multi-institute sequencing project and analyzed 66 PDAC cases recruited to ORIEN from The Ohio State University Wexner Medical Center and Moffitt Cancer Center for which tumor whole transcriptome sequencing datasets were generated. We separated the cases based on whether a tumor had originated from a cystic lesion (n=16) or presumably through the pancreatic intraepithelial neoplasia (PanIN) pathway (n=50). We then performed differential expression and pathway analysis using both Gene-Set Enrichment Analysis (GSEA) and Pathway Analysis with Down-weighted Genes (PADOG) algorithms. Based on the emerging importance of the immune landscape in PDAC development, we also analyzed immune profiles using a novel tool, Tumor-immune Microenvironment Deconvolution Web-portal for Bulk Transcriptomics (TIMEx). Results: When grouped by tumor origin, cyst-derived PDAC gene expression sets are enriched in immune signaling pathways, specifically NOTCH signaling (p=0.04), and demonstrate significant downregulation in amino acid metabolism, mitochondrial import and Gsα signaling pathways. Furthermore, GSEA based on TIMEx signatures indicated that multiple immune cell-specific profiles had significant enrichment scores in either the cyst-derived (for example, plasma cell: normalized enrichment score=-1.53; p=0.007) or non-cyst-derived (for example, neutrophil: normalized enrichment score=2.24; p=0.0001) PDAC cohorts. Conclusions: Our data suggest that cyst-derived and non-cyst-derived PDACs differ by immune profile, enhanced NOTCH pathway usage and in the metabolic processing of multiple amino acids. These initial findings support future studies to assess the accuracy of risk stratifying PCLs based on their amino acid, metabolic, or immune profiles, and exploration into mechanisms to explain these findings. Citation Format: Margaret A. Park, Somashekar G. Krishna, Maria C. Genilo-Delgado, Kristyn Gumpper-Fedus, Darwin L. Conwell, Phil A. Hart, Mary E. Dillhoff, Maria F. Gomez, Toni L. Basinski, Aamir N. Dam, Jason B. Klapman, Jason B. Fleming, Mokenge Malafa, Amir Mohammadi, Barbara A. Centeno, Kun Jiang, Daniel Jeong, Dung-Tsa Chen, Mengyu Xie, Aik Choon Tan, Brooke L. Fridley, Jamie K. Teer, Zobeida Cruz-Monserrate, Jennifer B. Permuth. Pathway and immune profile analysis of cyst-derived versus PanIN-derived pancreatic ductal adenocarcinomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2522.

Abstract SLP-76(SH2 domain-containing leukocyte protein of 76 kD) is a hematopoietic adapter protein that is expressed in myeloid and T cells. SLP-76 is a substrate for tyrosine kinase in the src and syk family activation pathway required for T-cell receptor-mediated signaling. Cross-linking of the human FcgammaRIIa1 (CD32) in myeloid cells which contains an immune receptor tyrosine-based activation motif (ITAM) causes phosphorylation of SLP-76. Mice deficient in SLP76 develop fetal hemorrhage along with failure of T cell development and perinatal mortality. We have found that K562 cells express SLP-76. We hypothesized that SLP-76 or associated proteins may be substrates of Bcr-Abl in the K562 cell line and thus promote survival signals. Materials and Methods: The K-562 cell line was obtained from the American collection of Cell Cultures. SLP deficient (−/−) KO mice were obtained from Dr. James Clements (Roswell Park Cancer Institute). Antibodies used include Sheep polyclonal IgG Anti-Human SLP 76, Peroxidase-conjugated Affinipure Donkey Anti-Sheep IgG at 0.8mg/ml, Mouse monoclonal IgG Anti-Phosphotyrosine, and Polyclonal goat Anti-mouse. Immunoprecipitation and Immunoblot: Cells were either untreated or stimulated with purvanidate (phosphatase inhibitors). Purvanidate treated cells were used as a positive control. Spleenocytes isolated from a SLP-76 deficient mouse (KO) were used as negative control. Lysates were then subject to standard immunoprecipitation for SLP-76 followed by immunoblotting with a SLP-76 specific antibody. The denatured samples were then resolved by SDS-PAGE. Results: SLP-76 is expressed in untreated and treated K562 with purvanidate and not detectable from lysates derived from SLP-76 KO spleenocytes. To assess the phosphorylation status of SLP-76 and any co-associated proteins in K562 cells, the SLP-76 blot was stripped and then immunoblotted for total phosphotyrosine content. SLP-76 does not appear to be constitutively phosphorylated in the K562 cells. However, significant tyrosine phosphorylation of SLP-76 was readily detectable in the purvanidate treated K562 cells. Conclusion: The current studies reveal that although SLP-76 is indeed found in the K562 cell line expressing the Bcr-Abl oncogene. Somewhat surprisingly, despite the constitutive activation of the Bcr-Abl tyrosine kinase in K562 cells, we detected no obvious phosphoproteins co-precipitating with SLP-76 in the absence of purvanidate stimulation. Together, the lack of SLP-76 tyrosine phosphorylation and the lack of co-associated proteins in K562 cells suggest that SLP-76 is not a major player in the signal transduction pathways emanating from Bcr-Abl. However, a more stringent confirmation of this conclusion would require inhibiting SLP-76 expression in K562 cells and than assessing the growth and survival characteristics. Figure Figure

Fusarium dry rot of potato can be caused by several species of Fusarium, but F. sambucinum is considered the primary cause in stored potatoes in North America and Europe (2). Potato tubers of cvs. Shepody and Russet Burbank with severe dry rot were collected from a commercial processing storage facility in central North Dakota during 2003–2004. Pathogen isolations were made from infected tubers on one-half strength acidified potato dextrose agar (APDA). Only F. graminearum was isolated from all rotted tubers used. Identification was based on colony morphology and conidial and perithecial characteristics, which included a carmine coloration of the underside of the agar and white fluffy mycelium on APDA, the presence of black perithecia on carnation leaf agar, and large distinctive macroconidia (1). The identity was confirmed by the Fusarium Research Institute at Pennsylvania State University. Pathogenicity was tested in potato tubers and greenhouse-grown potato plants cv. Atlantic. Nine tubers were wounded by removal of a plug of tissue with a cork borer, 3 mm in diameter and 5 mm deep, and inoculated by placing either 100 μl of a conidial suspension (5 × 104 conidia per ml) from a 7-day-old culture or a mycelial plug, 3 mm in diameter, from a 7-day-old culture in the wound. Nine tubers wounded and treated with either sterile distilled water or one-half strength APDA served as controls. Plant inoculations were performed by cutting a slit in the lower stem with a sterile scalpel and placing a cotton collar saturated with a conidial suspension (5 × 104 conidia per ml) around the wound and held in place with a clothespin. Four plants were inoculated with a conidial suspension, and four plants were treated with sterile distilled water. All tubers inoculated with either Fusarium treatment developed typical potato dry rot symptoms consisting of a brown, dry decay with mycelium lined cavities, and F. graminearum was reisolated from all symptomatic tubers. The control tubers did not develop symptoms. No symptoms developed in any of the greenhouse inoculated plants. Fifteen isolates were tested for sensitivity to thiabendazole, and all were sensitive with EC50 (50% effective concentration) values ranging from 0.8 to 3.7 μl/ml. The results indicate that F. graminearum can cause dry rot of potato, and to our knowledge, this is the first report of F. graminearum as a cause of potato dry rot. These results have epidemiological implications in the persistence, spread, and management of F. graminearum in cereals and potatoes, since potato is often used in rotation with other hosts of F. graminearum, including wheat, barley, and corn. References: (1) P. E. Nelson et al. Pages 118–119 in: Fusarium Species: An Illustrated Manual for Identification. The Pennsylvania State University, University Park and London, 1983. (2) G. A. Secor and B. Salas. Fusarium dry rot and fusarium wilt. Pages 23–25 in: Compendium of Potato Diseases. 2nd ed. W. R. Stevenson, R. Loria, G. D. Franc, and D. P. Weingartner, eds. The American Phytopathological Society, St. Paul, MN, 2001.

Abstract Background: Breast cancer is the most common cancer among women in the United States, with elevated circulating cholesterol as an established risk factor for the onset and progression to metastatic disease. The cholesterol metabolite, 27-hydroxycholesterol (27HC) has been identified to establish an immunosuppressive tumor microenvironment via Liver X Receptor (LXR) in myeloid immune cells. Interestingly, 27HC treatment of different myeloid immune cell types results in increased secretion of extracellular vesicles (EVs) with altered cargo. Importantly, EVs from 27HC treated myeloid cells promote tumor growth and metastasis in murine models of breast cancer. Given that these altered EVs are involved in cancer progression, it is imperative that we understand how their biogenesis and secretion are regulated. Methods and Results: Immunofluorescence microscopy experiments revealed that 27HC increases the size and number of CD63+ multivesicular bodies (MVBs) but not EEA1+ endosomes in RAW 264.7 cells. Quantitative PCR analysis revealed no significant changes in mRNA expression of genes associated with EV biogenesis machinery. However, we did observe that 27HC increased the size and number of LAMP1+ lysosomes. This led to the hypothesis that 27HC increases EV secretion by skewing MVBs away from lysosomal degradation and towards secretion as EVs by i) impairing lysosomal integrity, and/or ii) altering the post-translational modifications on the MVBs. To study the effect of 27HC on lysosomal function, we stained the lysosomes with a pH sensing fluorescent dye and observed a decrease in fluorescent intensity, indicating an increase in lysosomal pH. In addition, treatment with 27HC increased levels of cathepsin B in cells. Treatment of cells with Bafilomycin A1, a lysosomal proton pump inhibitor phenocopies the 27HC mediated increase in EV secretion and co-treatment of cells with Bafilomycin A1 and 27HC has the same effect. Post-translational modifications such as ISGylation and NEDDylation have been previously implicated in modulating EV secretion and cargo, and we have observed that 27HC decreases overall ISGylation and NEDDylation of proteins in cells. Conclusion: 27HC increases the size of multivesicular bodies, impairs lysosomal integrity, and alters levels of ISG- and NEDDylated proteins in cells. These data suggest that a combination of these modulations leads to the increase in EV secretion. Collectively, our studies reveal novel mechanisms by which EV secretion is modulated by 27HC. By extension, this axis represents a novel avenue for intervening in EV secretion and ultimately in the development of breast cancer therapeutics. Funding: Department of Defense Breast Cancer Research Program Era of Hope Scholar Award (BC200206), and National Cancer Institute (R01CA234025). Citation Format: Anasuya Das Gupta, Natalia Krawczynska, Hashni Epa Vidana Gamage, Hannah Kim, Jaena Park, Janet E. Sorrells, Stephen A. Boppart, Erik R. Nelson. 27-Hydroxycholesterol impairs lysosomal integrity in myeloid immune cells, resulting in enhanced secretion of cancer promoting extracellular vesicles [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1258.

Abstract Patients with peritoneal metastasis frequently identified in advanced gastric cancer (GC) have a poor prognosis with a median survival of 3-6 months. Because of innate resistance to treatment, these patients have limited therapeutic efficacy and contribute to high mortality. Therefore, it is necessary to understand the molecular characteristics of peritoneal metastasis and search for applicable drugs. This study aims to understand the biological characteristics of peritoneal metastasis in GC through integrative genomic analysis.A total of 66 GC cell lines were used, of which 11 were derived from the stomach, 49 from peritoneal and pleural fluids, and 6 from other origins. Targeted sequencing and RNA sequencing data were obtained from the Songdang Institute for Cancer Research (SICR) database. Cell lines were clustered into EMT and Non-EMT groups according to the expression profiles of 200 genes belonging to the EMT gene set (Nature Cancer, 2021, 2.9: 962-977.). We used gene sets from the Molecular Signatures Database v.7.0.Hierarchical clustering separated the 49 cell lines derived from peritoneal and pleural fluids into two distinct clusters (EMT group, n=20 and Non-EMT group, n=29). Cell lines in the EMT group were classified as GS (65%, 13/20) and CIN (35%, 7/20), whereas cell lines in the Non-EMT group were classified as EBV-positive (3.4%, 1/29), MSI-H (6.9%, 2/29), GS (37.9%, 11/29), and CIN (51.7%, 15/29). The gene set enrichment analysis (GSEA) revealed that gene sets (HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION, CORDENONSI_YAP_CONSERVED_SIGNATURE, and FRIDMAN_SENESCENCE_UP) shows statistically significant differences between the two compared groups. Gene expression levels were significantly different between the EMT and Non-EMT group. In detail, YAP/TEAD pathway related genes (TEAD1, TEAD3, CYR61, DKK1, SLC7A5, SLC2A3) and TGF-β pathway related genes (SMAD3, TGFβ1, TGFβ2, BMP1, INHBA) showed a higher expression level in the EMT group compared to the Non-EMT group (p&lt;0.05). Interestingly, GSEA between the EMT and Non-EMT groups of the GS subtype revealed that gene set CORDENONSI YAP CONSERVED SIGNATURE was enriched in the EMT group. Gene set FOROUTAN_TGFB_EMT_UP, on the other hand, was enriched in the EMT group of the CIN subtype (p&lt;0.05).In conclusion, we identified differences in gene expression levels according to molecular subtypes in GC cell lines with peritoneal metastasis. It can provide useful information to gain new insight into the mechanism of peritoneal metastasis and improve successful treatment options. Furthermore, our results suggest that YAP/TEAD may be considered a potential therapeutic target for GC with peritoneal metastasis. Citation Format: Juin Park, Woo Sun Kwon, Jingmin Che, Tae Soo Kim, Sang Woo Cho, Eun Seo Kim, Hyun Cheol Chung, Sun Young Rha. Genomic profiling of gastric cancer with peritoneal metastasis identifies molecular subtypes and a potential molecular-guided therapeutic strategy for intractable gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1399.

Abstract Background: Human epidermal growth factor receptor 2 (HER2) overexpression, amplification, or mutation occurs across a variety of solid tumors. Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has been approved by the FDA for HER2-overexpressed advanced breast, gastroesophageal cancers, HER2-low breast cancer, and HER2-mutated non-small cell lung cancer. However, some patients do not derive clinical benefit from T-DXd, and drug resistance is inevitable. Preclinical studies demonstrated that neratinib, an oral irreversible pan-HER tyrosine kinase inhibitor, can increase uptake of HER2-targeting ADCs, including ado-trastuzumab emtansine and T-DXd, in vivo. Enhanced uptake of ADC is postulated to be secondary to hindering HSP90 binding to the HER2 receptor, thereby inducing receptor ubiquitination and internalization. This finding was further confirmed in patient-derived xenograft models from two patients with HER2-mutated, but non-amplified, low-expressing advanced breast cancer. Therefore, we hypothesized that the combination of T-DXd and neratinib in patients with advanced solid tumors with a HER2 alteration will enhance the efficacy of T-DXd. As T-DXd and neratinib may have overlapping toxicities in patients, a phase I study to establish the safety of the combination is warranted. Methods: This is a multi-center, phase I clinical trial (NCT05372614, NCI 10495) with a 3+3 design to study the safety and tolerability of T-DXd and neratinib. The trial is supported by the National Cancer Institute Experimental Therapeutics Clinical Trials Network. Eligible patients have advanced solid tumors with HER2 overexpression, amplification by ISH/NGS, or an activating HER2 mutation. Up to 18 evaluable patients will be enrolled in the dose escalation portion (Part 1), and 12 patients will be enrolled in the pharmacodynamic cohort (Part 2). During Part 1, the maximum tolerated dose and recommended phase 2 dose will be determined for neratinib. The dose of T-DXd is fixed at 5.4 mg/kg. We are actively enrolling patients in Part 1. The primary endpoint is dose-limiting toxicities of the combination during the first 2 cycles of treatment (42 days). Key secondary objectives of the study include T-DXd payload (DXd/MAAA-1181a) in tumor tissue obtained before and after co-treatment with neratinib to assess the potential enhanced payload concentration with the combination and quantitative HER2 assessed by mass spectrometry using multiplex reaction monitoring. Citation Format: Andrew A. Davis, Ecaterina E. Dumbrava, Aparna Kalyan, Nataliya V. Uboha, Haider S. Mahdi, Reema A. Patel, Farshid Dayyani, Jessica Porzel, Whitney L. Hensing, Cynthia X. Ma, Ron Bose, Haeseong Park. Phase I trial of trastuzumab deruxtecan in combination with neratinib in solid tumors with HER2 alterations (NCI 10495) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT159.

Abstract Immune checkpoint inhibitors (ICIs) have been applied in patients with various solid tumors since they were approved by U.S. FDA in 2011. However, only less than 20% of patients benefit from ICIs including anti-programmed cell death protein 1 (aPD-1). Recently, many studies to improve the response of ICIs are in progress, and especially, vascular endothelial growth factor receptors (VEGFR) pathway was emerged as major target. VEGFR inhibitors regulate the differentiation of tumor-associated macrophage, antigen presenting dendritic cell, and T cell infiltration, so they make a synergic antitumor effect with ICIs. In this study, we investigated the effect of lenvatinib combined with anti-mouse PD-1 in syngeneic murine cervical cancer models to show whether VEGFRi enhance the antitumor effect of ICIs. We established syngeneic mouse models of cervical cancer to confirm synergic effect by lenvatinib combined with aPD-1. 1x107 cells of U14 cells were injected subcutaneously into the flanks of BALB/c wild- type (immunocompetent) mice and BALB/c nude (immunocompromised) mice. They were treated with lenvatinib when the tumor volume reached at 200 mm3, subsequently, aPD-1 was administered in immunocompetent mice. We administrated lenvatinib (10 mg/kg, orally, daily) and aPD-1(200 µg per mouse, intraperitoneally (I.P), twice a week) for 3 weeks. Tumor volume was measured twice a week. After the end of the experiment, we harvested tumors and spleens, and performed histological analysis. All experiments were approved by the Institutional Animal Use and Care Committee (IACUC) in Asan Institute for Life Science.Although the tumor was increased despite lenvatinib treatment in immunocompromised model with BALB/c nude mice, on the 17th day after injection, the tumor growth was inhibited in lenvatinib group compared with vehicle group (2914 mm3 vs. 3663 mm3, respectively) (P=0.0014). On the other hand, the tumor volume was significantly reduced by lenvatinib in the immunocompetent model (278 mm3 in Len vs. 490 mm3 in Veh) (P=0.0347), particularly the tumor size was decreased since 2 weeks of injection. Subsequently, we investigated the synergistic effects of combination with lenvatinib and aPD-1 in immunocompetent model. Each single treatment group showed the reduction of tumor volume compared to vehicle group (278 mm3 in Len and 258 mm3 in aPD-1 vs. 490 mm3 in Veh). Furthermore, the lenvatinib plus aPD-1 combination group reduced tumor volume to 110mm3 on the 24th day after injection and it was significantly different compared to each single treatment group (P=0.13868 and P=0.27385, respectively).In this study, anti-tumor effect of aPD-1 was enhanced by the regulation of tumor microenvironment with lenvatinib in immunocompetent murine cervical cancer models. In conclusion, addition of lenvatinib is expected to increase the efficacy of ICIs in patients with cervical cancer who have the resistance or insensitivity to ICIs. Citation Format: Su-Bin Park, Ji-Sik Kang, Min-Je Kim, Shin-Wha Lee, Dong-Woo Kang, Yong-Man Kim. Anti-tumor effects of lenvatinib plus anti-PD-1 in syngeneic murine cervical cancer models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6190.

Abstract Background. Cardiovascular and metabolic disorders are significant contributors to mortality among men with prostate cancer. However, no evidence is yet available for the role of cardiometabolic comorbidities in the tumor risk stratification or clinical management of men with prostate cancer. Like African American men, Puerto Rican men have a higher risk of developing and dying from prostate cancer than other racial/ethnic groups in the United States. As cardiovascular and metabolic risk factors are highly prevalent in Puerto Rico, we proposed to investigate coordinated risk evaluation of cardiometabolic and oncologic risk in this population. We hypothesized that a subset of cardiometabolic risk factors consistently correlate with clinically defined aggressive disease. Methods. The Puerto Rico Urology Group (PRUG) is the largest group urology practice in Puerto Rico. It currently consists of eight urologists serving the Western, Southern, Central, and Metropolitan regions of Puerto Rico including the island municipalities of Vieques and Culebra. A cohort (n=401) of patients treated to between 2018 and 2022 by the PRUG have been identified for analysis in this study, of which n=30 have been analyzed to date. Clinical data were extracted from consented patients’ medical records with approval by the Ponce Research Institute Institutional Review Board (IRB approval no. 2210121134). Post-surgical cancer of the prostate risk assessment (CAPRA-S) were used to stratify tumors and cardiovascular and metabolic risk factors were evaluated across tumor risk strata. Results. Of the 14 patients with intermediate or high risk, all had a body mass index over 26 compared to 7/16 patients with low-risk tumors (p=0.0009). Among patients with intermediate/high risk, 12/14 had high blood pressure compared to 8/16 patients with low-risk tumors (p=0.0577, RR=3.0). Hyperlipidemia was present in 5/14 patients with intermediate/high risk and 1/16 patients with low-risk tumors (p=0.0725, RR=2.22). Hypercholesterolemia was detected in 3/14 intermediate/high risk and in 6/16 low risk tumors (p=0.4397, RR=0.63). Other cardiometabolic risk factors including diabetes with complications and smoking status did not differ between cancer risk groups. Discussion. The Puerto Rican population represents the second largest Hispanic/Latino subgroup in the United States and has disproportionately high rates of prostate cancer and cardiometabolic comorbidity. Our preliminary findings indicate that the coordinated evaluation of cancer risk in the context of cardiovascular and metabolic risk factors may provide additional insights for risk stratification for patients with prostate cancer from populations with high prevalence of these chronic diseases. Although the study was limited by sample size, our findings provide insights for ongoing studies to evaluate large, multi-institutional cohorts and identify molecular indicators of cardiometabolic risk predictive of prostate cancer aggressiveness among diverse populations. Citation Format: Carlos J. Diaz Osterman, Nicole Torres Muriel, Shannalee R. Martinez, Noemi Santiago, Brenda L. Rodriguez Ruiz, Geoffrey Rodriguez, Eric Rosa, Ana M. Escalona Cruz, Ralph Krumhansl, Julie Dutil, Kosj Yamoah, Jong Y. Park, William Roman Torreguitart. Evaluating cardiometabolic and oncologic risk among Puerto Rican men with prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A076.

Abstract The mutated BRAF kinase (V600E) is considered the key component in the MAPK signaling pathway that was reported to be significantly contributed to melanoma disease. Vemurafenib and dabrafenib are examples of drugs that were approved by FDA to treat melanoma through inhibition of mutated BRAF kinase (V600E). However, drug resistance was reported after 6 - 7 months of treatment using these drugs due to activation of this signaling pathway through another RAF kinase (CRAF). As a Drug Discovery research group, we were interested to study and identify the possible biological target to inhibit this resistant form of cancer. We run molecular modelling simulation to study the key features of the active sites of RAF kinases and we taken vemurafenib as a starting point to design our compounds. We identified a selective back pocket in the active site of RAF kinases that can be targeted to enhance the inhibition of these kinases to overcome the drug resistance in the resistant melanoma. We designed a library of compounds based on imidazothiazole core scaffold decorated with different hydrophobic substituents to target the selectivity back pocket. Among the designed and synthesized series, KS16, that showed potent biological profile against RAF kinases compared to vemurafenib as a standard. In the cellular level, KS16 showed the same potencies against mutated BRAF-based melanoma cell line (A375) as that of vemurafenib. To evaluate the selectivity profile of KS16, kinase panel assay against 60 kinases has been investigated that showed high selectivity profile of KS16 (98 - 100% inhibition against WTBRAF, CRAF and V600EBRAF). In addition, KS16 was submitted to National Cancer Institute (NCI) to be tested against 60 human cancer cell lines in 5-point assay. It showed selective cytotoxic inhibition against melanoma cell lines compared to the other types of cancer cell lines. To evaluate the efficacy of KS16 against resistant melanoma, both KS16 and vemurafenib were tested against resistant melanoma cell line (A375R). The results revealed that KS16 showed the capability to inhibit the growth of resistant melanoma cell line in contrast to vemurafenib which failed to exhibit the same inhibition profile. The drug-candidate cardiac safety profile of KS16 was emphasized in this current project. KS16 was tested against hERG using E4031 (IC50 = 0.025 μM) as positive control to set up the hERG channel binding assay. The results revealed that KS16 showed relatively weak binding to hERG (% inh 64%) compared to that of the potent positive control (E4031, % inh 97%). The results revealed that KS16 is a potential drug candidate with minimal cardiotoxic effect. Further pharmacokinetic studies are being performed to KS16 to investigate and develop the ADME profile of KS16 to be a potential selected drug candidate against resistant melanoma disease. Citation Format: Usama Ammar, Mahmoud Gamal, Mohammed Abdel-Maksoud, Eslam Ali, Zeyad Mahmoud, Kim Deug, Park Jun, Soo Lee, Chang Oh. Discovery of potential RAF-selective back pocket as a promising biological target for BRAF inhibitors in the treatment of resistant melanoma: Design, synthesis, biological evaluation and in silico studies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4472.

Abstract Background: ESCC is the predominant histological subtype of esophageal cancer, accounting for 85% of cases. Patients (pts) with locally advanced/metastatic ESCC have poor clinical outcomes, with a 5-year survival rate of 6.1% for pts with distant metastases. 1L treatment with programmed cell death protein-1 (PD-1) inhibitors + platinum-based chemo has become the new standard of care for metastatic ESCC, however, there is an unmet need for enhanced treatment efficacy and a prolonged life span. LBL-007 is a monoclonal antibody (mAb) against lymphocyte activation gene-3 (LAG-3), an immune checkpoint receptor that negatively regulates T-cell activity. TIS is an anti-PD-1 mAb that blocks the PD-1/programmed death-ligand 1 (PD-L1) immune checkpoint, resulting in T-cell activation. This study (NCT06010303) aims to evaluate the efficacy and safety of LBL-007 + TIS + chemo as a 1L treatment in pts with unresectable, locally advanced/metastatic ESCC. Methods: This phase 2 study will enroll approximately 116 pts with a pathologically confirmed diagnosis of unresectable, locally advanced/metastatic ESCC and no prior systemic therapy. Pts will be randomized 2:1 to either Arm A (LBL-007 600 mg intravenously [IV] every 3 weeks [Q3W] + TIS 200 mg IV Q3W + chemo doublet) or Arm B (TIS 200 mg IV Q3W + chemo doublet), stratified by PD-L1 expression (tumor area positivity score ≥10% or &lt;10%). The chemo doublet will consist of either cisplatin (60-80 mg/m2 IV Q3W) + 5-fluorouracil (750-800 mg/m2 IV daily on Days 1-5 Q3W), or cisplatin + paclitaxel (175 mg/m2 IV Q3W), determined by the investigator before randomization. Treatments will be administered until disease progression, intolerable toxicity, or withdrawal for other reasons. The primary endpoint is the overall response rate, as assessed by the investigator per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Secondary endpoints include progression-free survival, duration of response, and disease control rate (all by investigator per RECIST v1.1), and the incidence and severity of adverse events per National Cancer Institute-Common Terminology Criteria for Adverse Events v5.0. A safety monitoring committee is monitoring the safety of LBL-007 + TIS + chemo vs TIS + chemo. Exploratory endpoints include comparison of overall survival, assessment of predictive, prognostic, and pharmacodynamic biomarkers, pharmacokinetic evaluation of LBL-007 and TIS, and immunogenicity. The study is currently recruiting at approximately 46 sites across Asia, including Taiwan, mainland China, South Korea, and Thailand. Citation Format: Sook Ryun Park, Ming-Huang Chen, Arunee Dechaphunkul, Ningning Ding, Xiao Lin, Jinghui Zhang, Vivian Li, Qiao Li, Yi Ba. BGB-A317-LBL-007-202: A phase 2, randomized, active-controlled, open-label study to evaluate the efficacy and safety of LBL-007 (anti-LAG-3) in combination with tislelizumab (TIS; anti-PD-1) plus chemotherapy (chemo) as first-line (1L) treatment in patients with unresectable locally advanced/metastatic esophageal squamous cell carcinoma (ESCC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT274.

Abstract Advanced gastric cancer (AGC) showed marked molecular heterogeneity with aggressive behavior and treatment resistance, especially AGC with ascites from peritoneal metastasis. Tumor organoids are valuable in vitro model for mimicking organ characteristics and are used for developing therapeutic strategies. Therefore, we aimed to understand the characteristics of organoids established from AGC patient-derived fluids. Also, we are in progress of setting up an organoid-immune cell co-culture model for drug screening of immune checkpoint inhibitors (ICI) for AGC. All established organoids from peritoneal and pleural fluid of AGC patients were authenticated through short tandem repeat (STR) profiling, comparing with their matched PBMCs. We compared the morphological characteristics using Operetta High Content Imaging (Perkin Elmer). Also, the in house targeted sequencing and RNA sequencing data were obtained from the genome database of the Song-Dang Institute for Cancer Research and it was verified using molecular methods. Then, we co-cultured organoids with healthy donor PBMCs that were pre-activated using anti-human CD3/CD28 Dynabeads (Gibco). 3D spheroids, rather than single cells, and the PBMCs were co-cultured in matrigel (Corning Inc.) for more than 3 days. The overall success rate of the organoid establishment was 53.8% (78/145), with different sources of peritoneal (54%, 61/113) and pleural fluids (53.1%, 17/32). The organoid success rate was various as in EBV positive (66.7%, 2/3) and dMMR (0%, 0/4). Based on the analysis of 91 patients eligible for histopathology, the success rate of HER2-negative (57.5%, 46/80) is higher than that of HER2-positive (36.4%, 4/11). The organoids were observed in a variety of morphologies categorized in 3 groups such as grape-like, compact and glandular structure. Based on genomic data of 31 organoids, we could subgrouping for TCGA subtypes and EMT subtype. RTKs were amplified in 10 organoids, including the amplification of ERBB2 (n=2), MET (n=4) and FGFR (n=4). And KRAS alterations including amplification (n=2) and G12A/D (n=2) mutation were also detected. Then, we established the condition for organoid-immune co-culture model with PBMCs with Dynabead activation for 3-10 days. We confirmed that higher dose of PBMCs killed the tumor cells with reduction of organoid size and partial disintegration. We established the proper PBMC dose and characterization to maintain the organoids co-culture for further drug (ICI) sensitivity testing. In conclusion, we evaluated phenotypic and molecular characteristics of gastric cancer organoids established from malignant peritoneal and pleural effusion. The established organoid-immune cell co-culture models can be utilized to evaluate a variety of drug screenings, including ICI and various combinations, helping in the selection of drugs for individual patient. Citation Format: Han Byeol Mun, juin Park, Jinsoo Jang, Jingmin Che, Tae Soo Kim, Woo Sun Kwon, Hyun Cheol Chung, Sun Young Rha. Molecular-genomic characterization of metastatic gastric cancer organoids and establishment of organoid-immune cell co-culture model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 229.

Abstract Type-2 cytokines are hypothesized to promote an immune-permissive milieu for cancer to grow. Through scRNAseq and CITEseq on human non-small cell lung cancer (NSCLC) and the krasG12Dp53−/− lung cancer model we previously described a tumor-enriched dendritic cell program of concomitant immunosuppression and activation which we termed the “mregDC,” that was also notable for a strong Th2 immune signature. We subsequently blocked the canonical Th2 cytokine IL-4 in vivo in tumor-bearing mice, and found that this significantly decreased lung tumor burden, which was recapitulated in multiple other tumor models. Furthermore, this effect synergized with PD-L1 blockade. Based on this data, we designed a clinical trial to assess if the addition of dupilumab, an anti-IL-4Ra antibody widely used for treatment of atopic diseases, may rescue responses to checkpoint blockade (NCT05013450). In this Phase 1b/2 trial, up to 21 patients with NSCLC that have progressed on prior anti-PD-(L)1 therapy will be enrolled. Patients continue PD-(L)1 blockade while receiving three doses of dupilumab, administered every three weeks, with initial radiographic assessment of response at 9 weeks. Patients without progression of disease then continue anti-PD-(L)1 alone. The primary endpoint of Phase 1b is safety and tolerability, while the primary endpoint of Phase 2, inclusive of patients from Phase 1b, is efficacy as per RECIST. Patients undergo pre- and on-treatment biopsies, pre-treatment stool collection for microbiome analysis, as well as blood collection at 6 timepoints for PBMCs, plasma and ctDNA. Here we report the Phase 1b portion that has completed accrual in which 6 patients were enrolled in a Phase 1b run-in to confirm safety and tolerability. There were no adverse events attributable to study treatment during Phase 1b in any of the 6 patients treated. Serum proteomic analysis of this cohort revealed that dupilumab treatment induced a profound increase in proinflammatory/tumoricidal immune effector molecules, and reversed a systemic Th2 cytokine signature. Furthermore, mass cytometry of circulating immune populations showed an expansion of cytotoxic lymphocyte populations and a reduction in immunosuppressive myeloid cells. The fourth patient treated on trial who had progressive disease after 9 cycles of consolidation checkpoint blockade following concurrent chemoradiation for squamous NSCLC was enrolled, and had a partial response at 9 weeks, with deepening of the PR at 25 weeks. This patient’s on-treatment biopsy showed a major increase in CD8 T cell tumor infiltration. Histological analysis using spatial transcriptomics and multiplexed imaging from these patients is ongoing, and will be reported at the conference. Based on this promising signal in the initial lead-in, the trial will proceed through Simon’s Two Stage design and enroll a full 21 patients as part of the Phase 2 expansion cohort. This clinical trial is funded entirely through philanthropy support through the Tisch Cancer Institute. Citation Format: Thomas Urban Marron, Nelson M. LaMarche, Matthew D. Park, Samarth Hegde, Bailey Fitzgerald, Clotilde Hennequin, Raphael Mattiuz, Meriem Belabed, Jessica Le Berichel, Barbara Maier, Nicole Hall, Justin Miller, Deborah B. Doroshow, Nicholas Rohs, Rajwanth Veluswamy, Nicholas Venturini, Jorge E. Gomez, Christian Rolfo, David Yankelevitz, Udit Chaddha, Timothy Harkin, Mary B. Beasley, Seunghee Kim-schulze, Sacha Gnjatic, Fred R. Hirsch, Miriam Merad. Rescuing response to ICI by blocking the type-2 immune axis in patients with NSCLC progressing on immunotherapy: A phase 1b/2 trial of dupilumab administered with checkpoint blockade [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr CT199.

RESUMENCon el presente trabajo se pretende, sobre el soporte bibliográfico que registra la trayectoria del gremio sartorial, aportar un enfoque inédito proporcionado por las fuentes archivísticas y documentales para la época: la identificación, relación y análisis de la función ejercida por los sastres de los reyes y de aquellos vinculados al estamento nobiliario en la horquilla cronológica seleccionada, comprendida entre los años 1450 y 1615, fecha del primer y último documento trabajados en este sentido. Esta línea de investigación nos permitirá descubrir desde individuos con deseos de medrar en la escala social, como los sastres andantes y estantes en corte, hasta un subgrupo más consolidado marcado por la continua insatisfacción de las deudas por parte de la nobleza. Secciones archivísticas como el Registro General del Sello, Cámara de Castilla, Registro de Ejecutorias o Consejo de Estado, pertenecientes a variados archivos estatales españoles, nos servirán para proporcionar una nutrida nómina, en relación diacrónica, de los sastres vinculados a la Corona castellana en este periodo. Por otro lado, se destacará el proteccionismo regio hacia la figura de este artesano cercano a las élites de poder, ejemplificándolo en figuras concretas. Finalmente se apuntarán las posibilidades de la documentación analizada para conocer en profundidad, y de la mano de fuentes históricas primarias, aspectos de la historia del vestido regio y del de los empleados de la corte.PALABRAS CLAVE: sastres, reyes, nobles, Corona de Castilla, 1450-1615ABSTRACTThe aim of the present work is, on the basis of the literature that records the trajectory of the sartorial profession, to offer a new approach provided by the archival and documentary sources of the time: the identification, relation and analysis of the function exerted by tailors to kings and to those linked to the nobility. This line of research will allow us to discover people ranging from individuals seeking to climb the social ladder, such as tailors living at the court, to a more consolidated subgroup marked by the continued non-payment of debts by the nobility. Archival sections such as the General Registry of the Seal, Chamber of Castile, Registry of Executives or Council of State, belonging to various Spanish state archives, will provide us with a long list, in diachronic terms, of the tailors linked to the Castilian Crown between 1450 and 1615, the dates of the first and last documents used for this purpose. Furthermore, I shall highlight royal protectionism vis-à-vis the figure of this craftsman close to the elites, offering specific examples. Finally, I shall refer to the potential of the documentation analysed to explore in depth, and via primary historical sources, aspects of the history of royal attire and that of court employees.KEY WORDS: tailors, kings, nobles, Crown of Castile, 1450-1615 BIBLIOGRAFÍAAlcega, J. de, Tratado de Geometría, Práctica y Traza, el cual trata de lo tocante al oficio de sastre…, Valladolid, Maxtor, 2009.Alvar Ezquerra, A., El nacimiento de una capital europea: Madrid entre 1561 y 1609, Madrid, Turner, 1989.Baleztena Abarrategui, J., “Ordenanzas contra los sastres que tuvieren paños faltosos (1533)”, Cuadernos de etnología y etnografía de navarra, 74 (1999), pp. 563-570.Bello León, J. M., y Hernández Pérez, M. B., “Una embajada inglesa a la corte de los Reyes Católicos y su descripción en el ‘Diario’ de Roger Machado”, En la España medieval, 26 (2003), pp. 167-202.Bouza Brey, F., “Historia de la cofradía gremial de sastres de Santiago de Compostela”, Revista Compostellanum, 7 (1962), pp. 569-620.Carretero Rubio, V., La artesanía textil y del cuero en Málaga (1487-1525), Málaga, Cedma, 1996.Comisión Internacional de Diplomática, Folia Caesaraugustana I (normas de transcripción y edición de documentos), Zaragoza, CSIC, Institución Fernando el Católico, 1984.Domínguez Ortiz, A., “Madrid de villa a corte”, en Historia y documentos notariales, Madrid, 16-2 (1992), pp. 263-279.Falcón Pérez, M. I., “Sobre la industria del vestido en Zaragoza en el siglo XV: las ordenanzas de la cofradía de sastres, calceteros y juboneros”, Aragón en la Edad Media, 12 (1995), pp. 241-266.Fernández García, J., “La consideración social de los sastres en la tradición asturiana: (poesía popular y paremiología)”, en Polledo Arias, A. C. (coord.), Fiestas Balesquida, Oviedo, 2012, pp. 89-103.Francisco Olmos, J. M. de, “La evolución de los cambios monetarios en el reinado de Isabel la Católica según las cuentas del tesorero Gonzalo de Baeza”, En la España medieval, 21 (1998), pp. 115-142.Gestoso Pérez, J. y Fernández Gómez, M., Noticia histórico-descriptiva del antiguo pendón de la ciudad de Sevilla y de la bandera de la Hermandad de los sastres, Sevilla, Área de Cultura, 1999.Gómez de Valenzuela, M., “La regla de la cofradía jaquesa de sastres, bajo la advocación de San Lorenzo (1602)”, Argensola: Revista de CC. Sociales del Instituto de Estudios Altoaragoneses, 113 (2003), pp. 315-328.González Arce, J. D., “De la corporación al gremio. La cofradía de sastres, jubeteros y tundidores burgaleses en 1485”, Studia historica. Historia medieval, 25 (2007), pp. 191-219.González Arce, J. D., La casa y corte del príncipe don Juan (1478-1497): economía y etiqueta en el palacio del hijo de los Reyes Católicos, Sevilla, Sociedad Española de Estudios Medievales, 2016.González Marrero, M. del C., “Un vestido para cada ocasión: la indumentaria de la realeza bajomedieval como instrumento para la afirmación, la imitación y el boato. El ejemplo de Isabel I de Castilla”, Cuadernos del CEMyR, 22 (2015), pp. 155-194.Haldón Reina, J. F., “Aproximación histórico-artística a la antigua Hermandad de Nuestra Señora de los reyes del gremio de sastres”, en Roda Peña, J. (coord.), II Semana de estudios Medievales, Nájera, 2009, pp.155-190.Juárez-Almendros, E., “Don Quijote y la moda: El legado de Carmen Bernis”, Cervantes: Bulletin of the Cervantes Society of America, 24.1 (2004), pp. 137-142.López García, J. M., El impacto de la corte en Castilla: Madrid y su territorio en la época moderna, Madrid, siglo XXI de España, 1998.Marchant Rivera, A., “Los sastres en los Procesos de fe del tribunal de distrito de la Inquisición de Toledo (1483-1597)”, Documenta & Instrumenta, 12 (2014), pp. 95-116.Martínez Carreño, A., “Sastres y modistas: notas alrededor de la historia del traje en Colombia”, Boletín Cultural y Bibliográfico, vol. 28, n. 28 (1991), pp. 61-76.Mediero Velasco, M. I., “El impacto de la corte sobre la villa de Madrid”, Pasea por Madrid: historia, turismo cultural y tiempo libre, 7 (2015), pp. 39-57.Monner Sans, R., De sastres: entretenimiento paremiológica, Talleres de la Casa Jacobo Peuser, 1909.Nieto Sánchez, J. A., “La conflictividad laboral en Madrid durante el siglo XVII: el gremio de sastres”, en Actas del I Congreso de jóvenes Geógrafos e Historiadores, 1995, pp. 283-289.Nieto Sánchez, J. A., Artesanos y mercaderes: una historia social y económica de Madrid (1450-1850), Madrid, Fundamentos, 2006.Nombela Rico, J. M., Auge y decadencia en la España de los Austrias: la manufactura textil de Toledo en el siglo XVI, Toledo, Ayuntamiento, 2003.Puerta Escribano, R. de la, “Los avatares del asociacionismo de los artífices del vestir en la Valencia Moderna”, en Prats, L. (coord.), Estudios en homenaje a la Profesora Teresa Puente, vol. 2, Valencia, 1996, pp. 481-495.Puerta Escribano, R. de la, Historia del gremio de sastres y modistas en Valencia: del siglo XIII al siglo XX, Valencia, Ayuntamiento, 1997.Puñal Fernández, T., Los artesanos de Madrid en la Edad Media (1200-1474), Madrid, UNED, 2000.Reguera Ramírez, R., “Costureras versus sastres. También una cuestión de género”, El Pajar: Cuaderno de etnografía canaria, 25 (2008), pp. 110-116.Rodríguez Plaza, M. Á., “Ordenanzas del gremio de sastres de Plasencia. Año 1795”, Revista de estudios extremeños, vol. 71, n. 2 (2015), pp. 1115-1136.Salazar y Castro, L., Pruebas de la historia de la casa de Lara sacadas de los instrumentos por…, Madrid, Imprenta Real, 1694, p. 102.Sanchís Llorens, R., “El offici de sastres y calcetters de Alcoy”, en Primer Congreso de Historia del País Valenciano: celebrado en Valencia del 14 al 18 de abril de 1971, vol. 3, Valencia, 1976, pp. 201-208.Vaamonde Lores, C., “La cofradía de los sastres de Betanzos”, Boletín de la Real Academia Galega, 46 (1911), pp. 244-251.Zofío Llorente, J. C., “Reproducción social y artesanos. Sastres, curtidores y artesanos de la madera madrileños en el siglo XVII”, Hispania: Revista española de Historia, 71/237 (2011), pp. 87-120.Zofío Llorente, J. C., Gremios y artesanos en Madrid, 1550-1650: la sociedad de trabajo en una ciudad cortesana preindustrial, Madrid, CSIC, 2005.

COVID-19 has impacted all areas of life, and youth sports is no exception. States and counties are publishing their own unique guidelines for permitting youth sports to return over designated phases, creating a patchwork of guidelines and dates for returning to practice and games. Governing bodies, sports facilities, and event operators are creating modifications and adaptations for participants and spectators to ensure a safe environment. The Sports Innovation Institute at IUPUI, a partnership between Indiana and Purdue universities in Indianapolis, and Grand Park Sports Campus (Westfield, Ind.) collaborated to better understand how COVID-related adaptations are perceived by parents, athletes, coaches, officials, and administrators. The results provide youth sports facilities and event operators with data on how specific adaptions are received by these stakeholders who are looking to return to youth sports in a timely, but safe manner. Twelve adaptations were identified from a review of documents prepared by states, governing bodies, trade associations, media reports, and feedback from industry and academic experts. The survey questions were designed using the Kano Model (pronounced “kah-no”), which was selected due to its ability to determine how people feel about proposed adaptions during the COVID-19 pandemic. Each adaption comprised three questions that assessed the respondents’ feelings toward the adaptation (functional question), their feelings if the adaptation did not exist (dysfunctional), and their assessment of how important it is for the adaptation to occur (importance). The Kano Model is interpreted based upon these three scores, and each adaptation can be placed into one of five categories on a scatterplot. The survey was distributed to 40 organizations that circulated the survey to their members. The survey reached a national audience that represents the landscape of youth sports. A total of 10,359 people from 45 states completed the entire survey, representing at least 13 different sports. Nearly 92% of respondents were parents, but with the option to select multiple roles, coaches (25%), administrators (10%), athletes (9%), and officials (3%) were also represented. Results indicated that venues and events should invest heavily and visibly in sanitization of the facility, playing areas, and equipment before, during, and after events. Venue operators and event managers can feel confident the recommendations provided by the Centers for Disease Control and Prevention (CDC) and National Federation of State High School Associations (NFHS) to sanitize playing areas and equipment after each use will be well-received and welcomed by users. Promotion and monitoring of social-distancing guidelines, limiting personal contact between players, limiting admission to those under age 65 with no CDC-indicated pre-existing conditions, and completing a health and contact-information questionnaire prior to entering are seen by users as must-be adaptations in order for players and spectators to feel comfortable returning to youth sports during the COVID-19 pandemic. This means their presence does not bring satisfaction, but their lack of presence brings significant dissatisfaction. Respondents felt indifferent toward changing arrival and departure routines, closing amenities, and minimizing the capacity and rearranging bench areas for athletes. The presence or absence of these adaptations do not make a real difference in users’ experiences. User sentiment regarding facemasks was mixed, with strong feelings about the use and non-use of facemasks. Finally, limiting entry to athletes and game personnel but excluding spectators was not well-received by survey respondents, especially parents. Youth sports venues and events should tread lightly when considering not allowing spectators into venues, and expect negative backlash from parents should such policies be adopted. Parents of recreational athletes viewed the adaptations in a more positive light and as a more necessary part of the youth sports experience than parents of travel athletes. A similar trend was found when comparing parents who are less willing to travel during the pandemic than those who do not expect their travel to be impacted. Travel sports parents demonstrated an increasing comfort level in traveling for competitions over the summer months, from 42% in May to 76% in August. The economic turmoil wrought by COVID-19 has touched nearly every component of American life. However, 59% of travel sports parents reported that the pandemic will not negatively impact their sports travel budget. Only 23% will experience a budget decrease greater than 25% related to youth sports travel.

-Peter Hulme, Stephen Greenblatt, New World Encounters. Berkeley: University of California Press, 1993. xviii + 344 pp.-Nigel Rigby, Alan Riach ,The radical imagination: Lectures and talks by Wilson Harris. Liège: Department of English, University of Liège, xx + 126 pp., Mark Williams (eds)-Jonathan White, Rei Terada, Derek Walcott's poetry: American Mimicry. Boston: North-eastern University Press, 1992. ix + 260 pp.-Ray A. Kea, John Thornton, Africa and Africans in the making of the Atlantic world, 1400-1680. Cambridge: Cambridge University Press, 1992. xxxviii + 309 pp.-B.W. Higman, Barbara L. Solow, Slavery and the rise of the Atlantic system. Cambridge: Cambridge University Press, 1991. viii + 355 pp.-Sidney W. Mintz, Michael Mullin, Africa in America: Slave acculturation and resistance in the American South and the British Caribbean, 1736-1831. Urbana: University of Illinois Press. 412 pp.-Karen Fog Olwig, Corinna Raddatz, Afrika in Amerika. Hamburg: Hamburgisches Museum für Völkerkunde, 1992. 264 pp.-Lee Haring, William Bascom, African folktales in the new world. Bloomington: Indiana University Press, 1992. xxv + 243 pp.-Frank Jan van Dijk, Dale A. Bisnauth, History of religions in the Caribbean. Kingston: Kingston Publishers, 1989. 225 pp.-Gloria Wekker, Philomena Essed, Everyday racism: Reports from women of two cultures. Alameda CA: Hunter House, 1990. xiii + 288 pp.''Understanding everyday racism: An interdisciplinary theory. Newbury Park CA: Sage, 1991. x + 322 pp.-Deborah S. Rubin, Vron Ware, Beyond the Pale: White women, racism, and history. London: Verso, 1992. xviii + 263 pp.-Michael Hanchard, Peter Wade, Blackness and race mixture: The dynamics of racial identity in Colombia. Baltimore: John Hopkins University Press, 1993. xv + 415 pp.-Rosalie Schwartz, Louis A. Pérez, Jr., Slaves, sugar, & colonial society: Travel accounts of Cuba, 1801-1899. Wilmington DE: SR Books, 1992. xxvi + 259 pp.-Susan Eckstein, Sandor Halebsky ,Cuba in transition: Crisis and transformation. With Carolee Bengelsdorf, Richard L. Harris, Jean Stubbs & Andrew Zimbalist. Boulder CO: Westview, 1992. xi + 244 pp., John M. Kirk (eds)-Michiel Baud, Andrés L. Mateo, Mito y cultura en la era de Trujillo. Santo Domingo: Librería La Trinitario/Instituto del Libro, 1993. 224 pp.-Edgardo Meléndez, Andrés Serbin, Medio ambiente, seguridad y cooperacíon regional en el Caribe. Caracas: Editorial Nueva Sociedad, 1992. 147 pp.-Dean W. Collinwood, Michael Craton ,Islanders in the stream: A history of the Bahamian people. Volume One: From Aboriginal times to the end of slavery. Athens: University of Georgia Press, 1992. xxxiii + 455 pp., Gail Saunders (eds)-Gary Brana-Shute, Alan A. Block, Masters of paradise: Organized crime and the internal revenue service in the Bahamas. New Brunswick NJ: Transaction Publishers, 1991. vii + 319 pp.-Michaeline Crichlow, Patrick Bryan, The Jamaican people 1880-1902. London: Macmillan Caribbean, 1991. xiv + 300 pp.-Faye V Harrison, Lisa Douglass, The power of sentiment: Love, hierarchy, and the Jamaican family elite. Boulder CO: Westview, 1992. xviii + 298 pp.-Frank Jan van Dijk, Bob Marley, Songs of freedom: From 'Judge Not' to 'Redemption Song.' Kingston: Tuff Gong/Bob Marley Foundation / London : Island Records, 1992 (limited edition). 63 pp. + 4 compact discs.-Riva Berleant-Schiller, Veront M. Satchell, From plots to plantations: Land transactions in Jamaica, 1866-1900. Mona: University of the West Indies, 1990. xiii + 197 pp.-Hymie Rubenstein, Christine Barrow, Family, land and development in St. Lucia. Cave Hill, Barbados: Institute for social and economic studies (ISER), University of the West Indies, 1992. xii + 83 pp.-Bonham C. Richardson, Selwyn Ryan, Social and occupational stratification in contemporary Trinidad and Tobago. St. Augustine, Trinidad: ISER, 1991. xiv + 474 pp.-Bill Maurer, Roland Littlewood, Pathology and identity: The work of Mother Earth in Trinidad. Cambridge: Cambridge University Press, 1993. xxii + 322 pp.-Robert Fatton, Jr., Brian Weinstein ,Haiti: The failure of politics. New York: Praeger, 1992. ix + 203 pp., Aaron Segal (eds)-Uli Locher, Michel S. Laguerre, The military and society in Haiti. Knoxville: University of Tennessee Press, 1993. x + 223 pp.-Paul E. Brodwin, Leslie G. Desmangles, The faces of the Gods: Vodou and Roman Catholicism in Haiti. Chapel Hill: University of North Carolina Press, 1992. xiii + 218 pp.-Marian Goslinga, Enid Brown, Bibliographical guide to Caribbean mass communication. John A. Lent (comp.). Westport CT: Greenwood Press, 1992. xi + 301 pp.''Suriname and the Netherlands Antilles: An annotated English-language bibliography. Metuchen NJ: Scarecrow Press, 1992. xi + 276 pp.-Jay B. Haviser, F.R. Effert, J.P.B. de Josselin de Jong, curator and archaeologist: A study of his early career (1910-1935). Leiden: Centre of Non-Western studies, University of Leiden, 1992. v + 119 pp.-Hans van Amersfoort, Anil Ramdas, De papegaai, de stier en de klimmende bougainvillea. Essays. Amsterdam: De Bezige Bij, 1992.-Ineke van Wetering, Deonarayan, Curse of the Devtas. Paramaribo: J.J. Buitenweg, 1992. v + 103 pp.-Ineke van Wetering, G. Mungra, Hindoestaanse gezinnen in Nederland. Leiden: Centrum voor Onderzoek Maatschappelijke Tegenstellingen, Rijksuniversiteit Leiden, 1990. 313 pp.-J.M.R. Schrils, Alex Reinders, Politieke geschiedenis van de Nederlandse Antillen en Aruba 1950-1993. Zutphen: Walburg Pers, 1993. 430 pp.-Gert Oostindie, G.J. Cijntje ,Stemmen OK, maar op wie? Delft: Eburon, 1991. 150 pp., A. Nicatia, F. Quirindongo (eds)-Genevieve Escure, Donald Winford, Predication in Caribbean English Creoles. Amsterdam & Philadelphia: John Benjamins, 1993, viii + 419 pp.-Jean D'Costa, Lise Winer, Trinidad and Tobago. Amsterdam & Philadelphia: John Benjamins, 1993. xi + 369 pp. (plus cassette)

ABSTRACT Previous studies mostly measured sharia financial inclusion using an index consisting of three dimensions: accessibility, availability, and usage. This research develops it by adding a digitalization dimension so that there are 4 dimensions in measuring sharia financial inclusion in Indonesia using an index. The first objective of this study is to visually illustrate the results of calculating the sharia financial inclusion index (in map form) in 33 provinces in Indonesia, using GeoDa software. Second, analyze the impact of sharia financial inclusion variables (the 4 form dimensions) that are calculated, on economic fundamental variables (growth, unemployment, poverty, and inequality) through a quantitative approach based on panel data analysis methods (FEM and REM). The secondary data used comes from the Financial Services Authority (OJK) and the Central Statistics Agency (BPS), in the 2015-2020 period. The results of this study indicate that sharia financial inclusion in Indonesia needs to be increased more evenly, so that it is not stagnant and centered in Java or provinces with a communal Muslim base (viewed from the results of index calculations) because the values ​​are unequal between provinces. Meanwhile, the results of panel data analysis techniques show that variables reflecting the 4 dimensions of sharia financial inclusion have an impact on fundamental economic variables. Keywords: Sharia Financial Inclusion, Index, GeoDa, Panel data ABSTRAK Kajian sebelumnya banyak mengukur inklusi keuangan syariah dengan menggunakan indeks yang terdiri dari tiga dimensi: aksessibilitas, availabilitas, dan penggunaan. Penelitian ini mengembangkannya dengan menambah dimensi digitalisasi, sehingga terdapat 4 dimensi dalam mengukur inklusi keuangan syariah di Indonesia menggunakan indeks. Tujuan pertama penelitian ini menggambarkan visual hasil perhitungan indeks inklusi keuangan syariah (dalam bentuk peta) di 33 provinsi yang ada di Indonesia, dengan software GeoDa. Kedua, menganalisis pengaruh variabel inklusi keuangan syariah (4 dimensi pembentuknya) yang dihitung, terhadap variabel fundamental ekonomi (pertumbuhan, tingkat pengangguran, kemiskinan, dan ketimpangan) melalui pendekatan kuantitatif berbasis metode analisis data panel (FEM dan REM). Data yang digunakan bersumber dari Otoritas Jasa Keuangan (OJK) dan Badan Pusat Statistika (BPS), dalam periode 2015-2020. Hasil penelitian ini, menunjukkan bahwa bahwa inklusi keuangan syariah di Indonesia perlu ditingkatkan lebih merata, agar tidak stagnan terpusat di Java atau provinsi dengan basis muslim komunal, jika dilihat dari hasil perhitungan indeks yang nilainya timpang antar porvinsi. Sementara itu, hasil teknik analisis data panel menunjukkan bahwa variabel yang mencerminkan 4 dimensi inklusi keuangan syariah berdampak bagi variabel fundamental ekonomi. Kata Kunci: Inklusi Keuangan Sharia, Indeks, Geoda, Data Panel. REFERENCES Allen, J., Cars, G., & Madanipour, A. (2012). Social exclusion in European cities: processes, experiences and responses. London: Routledge. Alshyab, N., Sandri, S., & Daradkah, D. (2021). The effect of financial inclusion on unemployment reduction-evidence from non-oil producing Arab countries. International Journal of Business Performance Management, 22(2-3), 100-116. Amakor, I. C., & Eneh, O. (2021). Financial inclusion and unemployment rate in Nigeria. International Journal of Research (IJR), 8(11), 1-14. Ananzeh, I. E. N. (2016). Relationship between bank credit and economic growth: Evidence in Jordan. International Journal of Financial Research, 7(2), 53-63. doi:10.5430/ijfr.v7n2p53 Anwar, K., & Amri, A. (2017). Pengaruh inklusi keuangan terhadap PDB Indonesia. Jurnal Ilmiah Mahasiswa Ekonomi Pembangunan, 2(3), 454-462. Arsyad, L. (2014). Konsep dan pengukuran pembangunan ekonomi. Modul Lincolin Arsyad, 1-46. Bansal, S. (2014). Perspective of technology in achieving financial inclusion in rural India. Procedia Economics and Finance, 11, 472-480. Demirgüç-Kunt, A., Beck, T. H. L., & Honohan, P. (2008). Finance for all? Policies and pitfalls in expanding access (No. aec73d3a-d6eb-457f-9182-3946fd15f0bc). Tilburg: Tilburg University, School of Economics and Management. Dienillah, A. A., & Anggraeni, L. (2016). Dampak inklusi keuangan terhadap stabilitas sistem keuangan di Asia. BMEB: Bulletin of Monetery Economics and Banking, 18(4), 409-430. doi:10.21098/bemp.v18i4.574 Fauzan, I. F. (2020). Determinan inklusi keuangan di Indonesia dengan pendekatan panel spasial. Disertasi. Program Doktoral IPB University. Bogor. Fosu, S. B., & Hampshire, N. (2013). Financial development and economic growth in Africa: A dynamic causal relationship. Thesis. The Degree of Master of Arts in Economics University of New Hampshire. Durham. Gupta, A., Chotia, V., & Rao, N. M. (2014). Financial inclusion and human development: A state-wise analysis from India. International Journal of Economics, Commerce and Management, 2(5), 1-23. Gurley, J. G., dan Shaw E. S. (1955). Financial aspects of economic development. The American Economic Review, 45(4), 515–538. Honohan, P. (2004). Financial development, growth and poverty: How close are the links? In E. C. Goodhard, ed., Financial development and economic growth: Explaining the links. London: Palgrave. Honohan, P. (2008). Cross-country variation in household access to financial services. Journal of Banking & Finance, 32(11), 2493-2500. doi:10.1016/j.jbankfin.2008.05.004 Ka’abi, M. S. (2020). Relevansi pemikiran ekonomi muhammad baqir as-sadr dalam keadilan distribusi beras di Indonesia. Skripsi. Program Sarjana Program Studi Ekonomi Syari;ah Institut Agama Islam Negeri Jember. Jember. Kim, D. W., Yu, J. S., & Hassan, M. K. (2018). Financial inclusion and economic growth in OIC countries. Research in International Business and Finance, 43, 1-14. doi:10.1016/j.ribaf.2017.07.178 Lakshmi, P., & Visalakshmi, S. (2013). Impact of cooperatives in financial inclusion & comprehensive development. Journal of Finance and Economics, 1(3), 49-53. doi:10.12691/jfe-1-3-4 Leyshon, A., & Thrift, N. (1995). Geographies of financial exclusion: financial abandonment in Britain and the United States. Transactions of the Institute of British Geographers, 20(3), 312-341. doi:doi.org/10.2307/622654 Lucas, R. E. (1988). On the mechanics of economic development. Journal Of Monetary Economics, 22(1), 3-42. doi:10.1016/0304-3932(88)90168-7 Luo, J., & Li, B. Z. (2022). Impact of digital financial inclusion on consumption inequality in China. Social Indicators Research, 163(2), 529-553. doi:10.1007/s11205-022-02909-6 Masnita, Y., Triyowati, H., & Khomsiyah, K. (2020). Pemberdayaan lembaga keuangan syariah dalam meningkatkan peran inklusi keuangan. JUARA: Jurnal Wahana Abdimas Sejahtera, 1(1), 26-37. doi:10.25105/juara.v1i1.5911 McKinnon, R. I. (1973). Money and capital in economic development. Washington, DC: Brookings Institution. Mehry, E. B., Ashraf, S., & Marwa, E. (2021). The impact of financial inclusion on unemployment rate in developing countries. International Journal of Economics and Financial Issues, 11(1), 79-93. doi:10.32479/ijefi.10871 Miller, M. H. (1988). Financial markets and economic growth. Journal of Applied Corporate Finance, 11(5):8−15. doi:10.1111/j.1745-6622.1998.tb00498.x Mohieldin, M., Iqbal, Z., Rostom, A., & Fu, X. (2011). The role of Islamic finance in enhancing financial inclusion in Organization of Islamic Cooperation (OIC) countries. World Bank Group: Policy Research Working Paper. doi:10.1596/1813-9450-5920 Neaime, S. & Gaysset. (2018). Financial inclusion and stability in MENA: Evidence from poverty and inequality. Finance Research Letters, 24,230-237. doi:10.1016/j.frl.2017.09.007 Nkwede, F. (2015). Financial inclusion and economic growth in Africa: Insight from Nigeria. European Journal of Business and Management, 7(35), 71-80. Omar, M. A., & Inaba, K. (2020). Does financial inclusion reduce poverty and income inequality in developing countries? A panel data analysis. Journal of economic structures, 9(1), 1-25. doi:10.1186/s40008-020-00214-4 Park, C. Y., & Mercado Jr, R. (2018). Financial inclusion, poverty, and income inequality. The Singapore Economic Review, 63(01), 185-206. doi:10.1142/S0217590818410059 Patrick, H. T. (1966). Financial development and economic growth in underdeveloped countries. Economic development and Cultural change, 14(2), 174-189. Polloni-Silva, E., da Costa, N., Moralles, H. F., & Sacomano Neto, M. (2021). Does financial inclusion diminish poverty and inequality? A panel data analysis for Latin American countries. Social Indicators Research, 158(3), 889-925. Puspitasari, S., Mahri, A. J. W., & Utami, S. A. (2020). Indeks inklusi keuangan syariah di Indonesia tahun 2015-2018. Amwaluna: Jurnal Ekonomi dan Keuangan Syariah, 4(1), 15-31. doi:10.29313/amwaluna.v4i1.5094 Riswanto, A., Tanjung, H., & Devi, A. (2021). Dampak inklusi keuangan dan bank syariah terhadap kesehatan dan pendidikan nasional. El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam, 2(2), 1-26. doi:10.47467/elmal.v2i2.518 Rostow, W. W. (1959). The stages of economic growth. The Economic History Review, 12(1), 1-16. doi:10.2307/2591077 Robinson, J. (1952). The generalization of the general theory. In The Rate of Interest and Other Essays. London: MacMillan. Romer, P. M. (1990). Endogenous technological change. Journal of Political Economy, 98(5):71−102. Romer, P. M. (1986). Increasing returns and long-run growth. Journal of Political, 94(5):1002−1037. Sanjaya, I. M., & Nursechafia, N. (2016). Financial inclusion and inclusive growth: A cross-province analysis in Indonesia. BMEB: Buletin of Monetary Economics and Banking, 18(3), 281-306. doi:10.21098/bemp.v18i3.551 Sarma, M. (2012). Index of financial inclusion–a measure of financial sector inclusiveness. Centre for International Trade and Development, School of International Studies Working Paper Javaharlal Nehru University. Delhi, India. Sarma, M., & Pais, J. (2011). Financial inclusion and development. Journal of International Development, 23(5), 613-628. doi:10.1002/jid.1698 Schumpeter, J. (1911). The theory of economic development: An inquiry into profits, capital, credit, interest and the business cycle. Cambridge: Harvard University Press. Sethi, D., & Acharya, D. (2018). Financial inclusion and economic growth linkage: Some cross country evidence. Journal of Financial Economic Policy, 10(3), 369-385. doi:10.1108/JFEP-11-2016-0073 Simatupang, M., Sinaga, B. M., Hartoyo, S. & Haryanto (2020). Impact of financial inclusion, government expenditures in education and health sectors on human development in Indonesia. Journal of Economic Development, Environment and People, 9(2), 5-17. doi:10.26458/jedep.v9i2.643 Singh, K., & Kondan, A. S. (2011). Financial inclusion, development and its determinants: An empirical evidence of indian states. The Asian Economic Review: Journal of the Indian Institute of Economics, 53(1), 115-134. Siswa, I., & Agustin, G. (2020). Analisis pengaruh inklusi keuangan terhadap indeks pembangunan manusia di Indonesia tahun 2015. Jurnal Ilmiah Ekonomi dan Bisnis, 17(2), 121-130. doi:10.31849/jieb.v17i2.4091 Umar, A. I. (2017). Index of syariah financial inclusion in Indonesia. BMEB: Buletin of Monetary Economics and Banking, 20(1), 99-126. doi:10.21098/bemp.v20i1.726

e4360011The objective of this research was to analyze how official documents and educational legislation present the subject of ethnic-racial diversity, and also reflect on their impact on reality through the National Household Sample Survey (PNAD) data. To this end, we conducted an analysis of legislation and official documents created for Brazilian education, from 1988 to 2018, based on the Bardin Content Analysis technique. Subsequently, this analysis was compared with the data available in the PNAD to verify the impact of publications regarding 1) average years of study by color/race in the period; 2) average years of study by color/race, considering the situation of poverty (extremely poor, vulnerable, poor and non-poor); and 3) average years of study in regions of Brazil with a higher percentage of black people. The prescriptions related to the education of ethnic-racial relations of the 12 files analyzed were described, as well as their categories and characteristics. After this process, were established the relations between the categories and the PNAD data. The results allowed us to conclude that the reduction in the average time difference between blacks and whites was a little less than 5 months. Despite the relevance of the efforts, the implementation of policies aimed at combating racial inequality in education is still far from achieving the expected effectiveness.ResumoO objetivo dessa pesquisa foi analisar como são tratadas, em documentos oficiais e na legislação educacional, as questões relativas à diversidade étnico-racial e refletir sobre o seu impacto na realidade por meio dos dados da Pesquisa Nacional por Amostra de Domicílios (PNAD). Para tanto, foi realizada uma análise das legislações e documentos oficiais criados para a educação brasileira, do período de 1988 a 2018, pautada na técnica da Análise de Conteúdo da Bardin. Subsequentemente, essa análise foi comparada com os dados disponíveis na PNAD para verificar o impacto das publicações com relação a: 1) média de anos de estudo por cor/raça, no período; 2) média de anos de estudo por cor/raça, considerando a situação de pobreza (extremamente pobres, vulneráveis, pobres e não pobres); e 3) média de anos de estudo em regiões do Brasil com percentual maior de pessoas negras. As prescrições relacionadas à educação das relações étnico-raciais dos 12 arquivos analisados foram descritas, assim como as categorias e as características que as compõem. Após esse processo, foram estabelecidas as relações entre as categorias e os dados da PNAD. Os resultados permitiram concluir que a redução da diferença de tempo médio de estudo entre brancos e negros foi de pouco menos de 5 meses. Apesar da relevância dos esforços, a implementação das políticas que visam o combate à desigualdade racial na educação ainda se apresenta longe de alcançar a eficácia esperada.Palavras-chave: Relações étnico-raciais, Legislação educacional, Desigualdades raciais, Análise de conteúdo.Keywords: Ethnic-Racial relations, Educational legislation, Racial inequalities, Content analysis.ReferencesAGUIAR, Márcia Angela Da S. Avaliação do plano nacional de educação 2001-2009: questões para reflexão. Educação Sociedade, Campinas, v. 31, n. 112, p. 707-727, set. 2010.ARTES, Amelia; MENA-CHALCO, Jesús Pascual. O Programa de Bolsas da Fundação Ford: 12 anos de atuação no Brasil. Educação e Realidade, Porto Alegre, v.44, n.3, p.1-22, 2019.BARDIN, Laurence. Análise de conteúdo. 4. ed. Lisboa: Edições 70, 2011, 279 p.BARROS, Marilisa Berti de Azevedo; FRANCISCO, Priscila Maria Stolses Bergamo; ZANCHETTA, Luane Margarete; CESAR, Chester Luiz Galvão. Tendências das desigualdades sociais e demográficas na prevalência de doenças crônicas no Brasil, PNAD: 2003-2008. Ciência saúde coletiva, Rio de Janeiro, v.16, n.9, p. 3755-3768, set. 2011.BRASIL. Ministério da Educação e Cultura. Base Nacional Comum Curricular. Brasília: MEC, 2017. Disponível em: https://tinyurl.com/y4lqrr4s. Acesso em: 06 de maio de 2020.BRASIL. Ministério da Educação e Cultura. Plano Nacional de Educação PNE 2014 2024. Brasília: MEC, 2015. Disponível em: http://pne.mec.gov.br/18planossubnacionais-de-educacao/543-plano-nacional-deeducacao-lei-n-13-005-2014. Acesso em: 06 de maio 2020.BRASIL. Ministério da Educação e Cultura. Planejando a Próxima Década Conhecendo as 20 Metas do Plano Nacional de Educação. Brasília: MEC, 2014a. Disponível em: http://pne.mec.gov.br/images/pdf/pne_conhecendo_20_metas.pdf. Acesso em: 20 de maio 2020.BRASIL. Ministério da Educação e Cultura. Lei nº 13.005, de 25 de junho de 2014. Aprova o Plano Nacional de Educação-PNE e dá outras providências. Brasília, 2014b. Disponível em: http://www.planalto.gov.br/ccivil_03/_ato2011-2014/2014/lei/l13005.htm. Acesso em: 21 de maio 2020.BRASIL. Ministério da Educação e Cultura. Lei n° 010172, de 9 de janeiro de 2001. Aprova o Plano Nacional de Educação-PNE e dá outras providências. Brasília: MEC, 2001. Disponível em: http://portal.mec.gov.br/arquivos/pdf/L10172.pdf. Acesso em: 22 de maio 2020.BRASIL. Ministério da Educação e Cultura. Plano Nacional de Implementação das Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-Raciais e para o Ensino de História e Cultura Afro-Brasileira e Africana. Brasília: MEC, 2013. Disponível em: http://portal.mec.gov.br/index.php?option=com_docmanview=downloadalias=10098-diretrizes-curricularesItemid=30192. Acesso em: 30 de maio 2020.BRASIL. Ministério da Educação e Cultura. Lei nº 12.711, de 29 de agosto de 2012. Brasília, 2012. Disponível em: http://www.planalto.gov.br/ccivil_03/_ato2011-2014/2012/lei/l12711.htm. Acesso em: 30 de maio 2020.BRASIL. Ministério da Educação e Cultura. Orientações e Ações para a Educação das Relações Étnico-Raciais. Brasília: SECAD, 2006. Disponível em: http://portal.mec.gov.br/dmdocuments/orientacoes_etnicoraciais.pdf. Acesso em 28 de maio 2020.BRASIL. Ministério da Educação e Cultura. Parecer CNE/CP 3/2004. Diretrizes curriculares nacionais para a educação das relações étnico-raciais e para o ensino de história e cultura afro-brasileira e africana. Diário Oficial da República Federativa do Brasil, Poder Executivo, Brasília, 2004a. Disponível em: http://portal.mec.gov.br/dmdocuments/cnecp_003.pdf. Acesso em: 23 de maio 2020.BRASIL. Ministério da Educação e Cultura. Diretrizes curriculares nacionais para a educação das relações étnico-raciais e para o ensino de história e cultura afro-brasileira e africana. Brasília, 2004b. Disponível em: http://portal.mec.gov.br/cne/arquivos/pdf/res012004.pdf. Acesso em: 27 de maio 2020.BRASIL. Ministério da Educação e Cultura. Lei nº 10.639/03, de 09 de janeiro de 2003. Brasília, 2003. Disponível em: http://www.planalto.gov.br/ccivil_03/leis/2003/l10.639.htm. Acesso em 26 de maio 2020.BRASIL. Ministério da Educação e Cultura. Parâmetros Curriculares Nacionais: Apresentação dos Temas Transversais: Ética. Rio de Janeiro: DPA, 2000. Disponível em: http://portal.mec.gov.br/seb/arquivos/pdf/livro081.pdf. Acesso em: 25 de maio 2020.BRASIL. Ministério da Educação e Cultura. Lei nº 9.394/96, de 20 de dezembro de 1996. Brasília: MEC, 2017. Disponível em: http://www.planalto.gov.br/ccivil_03/leis/l9394.htm. Acesso em: 24 de maio 2020.BRASIL. Constituição da República Federativa do Brasil, de 1988. In: PLANALTO FEDERAL. Brasília, 1988. Disponível em: http://www.planalto.gov.br/ccivil_03/constituicao/constituicao.htm. Acesso em: 20 de out. 2019.CAMARGO, Marisson Jonas Rodrigues; BENITE, Ana Maria Canavarro. Educação para as relações étnico-raciais na formação de professores de química: sobre a Lei 10.639/2003 no Ensino Superior. Química Nova, São Paulo, v. 42, n. 6, p. 691-701, 2019.CANDAU, Vera Maria; KOFF, Adélia Maria Nehme Simão. Conversas com... sobre a didática e a perspectiva multi/intercultural. Educação Sociedade, Campinas, v. 27, n. 95, p. 471-493, maio/ago. 2006.CARTH, John Land. A Base Nacional Comum Curricular e a aplicação da política de Educação para Educação das Relações Etnico-Raciais (afro-brasileira, quilombola, cigana). Brasília, 2017 Disponível em: http://etnicoracial.mec.gov.br/images/pdf/artigos/A-BNCC2018-e-aERER.pdf. Acesso em: 20 out. 2019.CASEIRO, Luiz Carlos Zalaf. Desigualdades de acesso à educação superior no Brasil e o Plano Nacional de Educação. Rio de Janeiro: IPEA, 2016, 40 p.CASTRO, Felipe González et al. A Methodology for conducting integrative mixed methods research and data analyses. Journal of Mixed Methods Research, v. 4, n. 4, p. 342-360, 2010.CAVALLEIRO, Eliane. Educação anti-racista: compromisso indispensável para um mundo melhor. In: Racismo e anti-racismo na educação: Repensando nossa escola. CAVALLEIRO, Eliane (Org.) São Paulo: Selo Negro Edições, 2001, 213 p.CERVI, Emerson Urizzi. Ações afirmativas no vestibular da UFPR entre 2005 a 2012: de política afirmativa racial a política afirmativa de gênero. Revista Brasileira de Ciência Política, Brasília, n. 11, p. 63-88, ago, 2013. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttextpid=S0103-33522013000200003lng=ennrm=iso. Acesso em: 18 de mar. 2020. https://doi.org/10.1590/S0103-33522013000200003.CODES, Ana; ARAÚJO, Herton Ellery; BASSI, Camillo; MEIRA, Ana. Uma leitura do plano nacional de educação (PNE) e uma proposta para seu monitoramento. Brasília: IPEA, 2017.COELHO, Mauro Cezar; COELHO, Wilma Nazaré Baía. As Licenciaturas em História e a Lei 10.639/03 – percursos de formação para o trato com a diferença? Educação em Revista, Belo Horizonte, v. 34, p. 1-39, 2018.COELHO, Wilma de Nazaré Baía. Formação de professores e relações étnico-raciais (2003-2014): produção em teses, dissertações e artigos. Educar em Revista, Curitiba, v. 34, n. 69, p. 97-122, maio/jun. 2018.CORDEIRO, Maria José de Jesus Alves. Ac?o?es afirmativas: poli?ticas de acesso e permane?ncia nas instituic?o?es de ensino superior. Política Trabalho, João Pessoa, n. 33, p. 97-115, out. 2010.COSTA, Célia Souza da; CUSTÓDIO, Elivaldo Serrão. A Lei n° 10.639/2003 no âmbito escolar: os avanços e entraves do Núcleo Estadual de Educação Étnico Racial no Amapá. Identidade! v. 20, n. 1, p. 64-77, 2015.DAFLON, Verônica Toste; JÚNIOR, João Feres; CAMPOS, Luiz Algusto. Race-based affirmative actions in brazilian public higher education: an analytical overview. Cadernos de Pesquisa, Rio de Janeiro, v.43, n.148 p. 302-327, jan./abr., 2013.DIAS, Lucimar Rosa. Quantos passos já foram dados? A questão de raça nas leis educacionais: da LDB de 1961 à Lei 10.639. Revista Espaço Acadêmico, v. 38, p. 1-16, 2004.DUARTE, Juliana Calabresi Voss; MENDES, Claudinei Magno Magre. As políticas de educação e o Plano Nacional de Educação (2014-2024): análise da materialização das propostas do plano. Série-Estudos, Campo Grande, v. 23, n. 48, p. 173-193, maio/ago., 2018.FERES JR., João; CAMPOS, Luiz Augusto. Evolução do Debate Sobre Ação Afirmativa no Brasil: prognósticos passados e diagnósticos presentes. In: ARTES, Amélia; UNBEHAUN, Sandra; SILVERIO, Valter. Ações Afirmativas no Brasil: reflexões e desafios para a pós-graduação. São Paulo: Cortez, 2016. p. 241-266.FERREIRA, Windyz Brazão. O conceito de diversidade no BNCC Relações de poder e interesses ocultos. Revista Retratos da Escola, Brasília, v. 9, n. 17, p. 299-319, jul./dez., 2015.FERREIRA, Lusia Ribeiro. Efeitos das ações afirmativas na permanência e desempenho do estudante, sob a ótica da teoria da justiça: um estudo em uma Universidade Federal do Rio Grande do Sul. 96f., 2019. Dissertação (Programa de Pós-Graduação em Contabilidade). Universidade Federal do Rio Grande do Sul, 2019.FONSECA, João José Saraiva. Metodologia da pesquisa científica. Fortaleza: UEC, 2002, 127 p. Disponível em: http://www.ia.ufrrj.br/ppgea/conteudo/conteudo-2012-1/1SF/Sandra/apostilaMetodologia.pdf. Acesso em: 16 de março de 2020.GARCIA, Francisco Augusto da Costa; JESUS, Girlene Ribeiro. Uma avaliação do sistema de cotas raciais da Universidade de Brasília. Estudos em avaliação Educacional, São Paulo, v. 26, n. 61, p. 146-165, jan./abr., 2015. Disponível em: http://publicacoes.fcc.org.br/ojs/index.php/eae/article/view/.2773/2959. Acesso em: 20/03/ 2020.GOIZ, Juliana Almeida Martins. A Educação para as Relações Étnico Raciais Sob a Perspectiva da Interdisciplinaridade. Veredas - Revista Interdisciplinar de Humanidades, São Paulo, v. 2, n. 3, p. 113-132, jul., 2019.GOMES, Nilma Lino. Relações Étnico-Raciais, Educação e Descolonização dos Currículos. Currículo sem Fronteiras, v. 12, n. 1, p. 98-109, jan./abr. 2012.GOMES, Nilma Lino; RODRIGUES, Tatiane Consentino. Resistência democrática: a quetão racial e a constituição federal de 1988. Educação Sociedade. Campinas, v. 39, n. 145, p.928-945, out./dez., 2018.GERHARDT, Tatiana Engel; SILVEIRA, Denise Tolfo. Métodos de Pesquisa. Porto Alegre: Editora UFRGS, 2009. 120 p.GOMES, Joaquim Barbosa. Ação afirmativa e princípio constitucional da igualdade: o direito como instrumento de transformação social e a experiência americana. Rio de Janeiro: Renovar, 2001. 454 p.GOMES, Nilma Lino. Diversidade étnico-racial, inclusão e equidade na educação brasileira: desafios, políticas e práticas. RBPAE, Rio Grande do Sul, v. 27, n. 1, p. 109-121, jan./abr., 2011.GUIMARÃES, Selva. The teaching of Afro-Brazilian and indigenous culture and history in Brazilian basic education in the 21st century. Policy Futures in Education, v. 13, n. 8, p. 939-948, 2015.HENRIQUES, Ricardo. Desigualdade Racial no Brasil: evolução das condições de vida na década de 90. Rio de Janeiro: IPEA, 2001, 52 p.HERINGER, Rosana. Desigualdades raciais no Brasil: síntese de indicadores e desafios no campo das políticas públicas. Caderno de Saúde Pública, Rio de Janeiro, v. 18, p. 57- 65, 2002.IBGE. Instituto Brasileiro de Geografia e Estatística. Pesquisa Nacional por Amostra de Domicílios: Síntese de Indicadores 2018 de Educação: IBGE; 2018. Disponível em: https://www.ibge.gov.br/estatisticas/sociais/educacao/9173-pesquisa-nacional-por-amostra-de-domicilios-continua-trimestral.html?=t=downloads. Acesso em 30 de mar. 2020.JACCOUD, Luciana. O combate ao racismo e à desigualdade: o desafio das políticas públicas de promoção da igualdade racial. In: THEODORO, Mário (Org.). As políticas públicas e a desigualdade racial no Brasil: 120 anos após a abolição. Brasília: IPEA, 2008, 180 p.JÚNIOR, Fernando Tavares; MONT'ALVÃO, Arnaldo; NEUBERT, Luíz Flávio. Rendimento escolar e seus determinantes sociais no Brasil. Revista Brasileira de Sociologia-RBS, Belo Horizonte, v. 3, p. 117-138, 2015.LASTÓRIA, Andrea Coelho. Resenha: Educação das Relações Étnico-Raciais. Paidéia, Ribeirão Preto, p. 275-276, out., 2006.LIMA, Márcia. Desigualdades raciais e políticas públicas: ações afirmativas no governo Lula. Novos estudos - CEBRAP, São Paulo, n. 87, p. 77-95, jul., 2010.MIQUILIN, Isabella de Oliveira Campos et al. Desigualdades no acesso e uso dos serviços de saúde entre trabalhadores informais e desempregados: análise da PNAD 2008, Brasil. Caderno de Saúde Pública, Rio de Janeiro, v. 29, n. 7, p. 1392-1406, jul., 2013. Available from http://www.scielo.br/scielo.php?script=sci_arttextpid=S0102-311X2013000700013lng=ennrm=iso. Acesso em: 18 de mar. 2020. MOREIRA, Romilson do Carmo. Três ensaios sobre educação, desigualdades raciais e políticas de ações afirmativas. 2019, 89 f. Tese Doutorado. Programa de Pós-Graduação em Economia do Desenvolvimento. Pontífica Universidade Católica do Rio Grande do Sul, Rio Grande do Sul, 2019.MÜLLER, Tânia Mara Pedroso; COELHO, Wilma de Nazará Baía. A Lei n° 10.639/03 e a formação de professores: trajetória e perspectivas. Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN), Minas Gerais, v. 5, n. 11, p. 29-54, out., 2013.MUNANGA, Kabengele. Políticas de ação afirmativa em benefício da população negra no Brasil: um ponto de vista em defesa de cotas. Sociedade e Cultura, Goiás, v. 4, n. 2, p. 31-43, jul. /dez., 2001.OLIVEIRA, Fabiana de. A educação básica e o tratamento da questão racial: as implicações da lei 10.639 para a formação de professores. Revista Educação e Políticas em Debate, Uberlândia, v. 2, n. 1, p. 53-75, jan./jul., 2013.OLIVEIRA, Elânia. A Lei 10.639/2003 e a Escola de Educação Especial: um desafio a mais para a formação de professores. Educar em Revista, Curitiba, n. 47, p. 85-95, jan./mar. 2014.PENA, Mariza Aparecida Costa; MATOS, Daniel Abud Seabra; COUTRIM, Rosa Maria da Exaltação. Percurso de estudantes cotistas: ingresso, permanência e oportunidades no ensino superior. Avaliação, Campinas, v. 25, n. 01, p. 27-51, mar. 2020.RODRIGUES, Erica Castilho; MATOS, Daniel Abud Seabra; FERREIRA, Aline dos Santos. Nível socioeconômico e ensino superior: cálculo e aplicações. Avaliação, Campinas, v. 22, n. 2, p. 494-511, jul. 2017.SANTIAGO, Flávio. Políticas educacionais e relações étnico-raciais: contribuições do Parecer CNE/CP 3/2004 para a educação infantil no Brasil. Revista on line de Política e Gestão Educacional, São Paulo, n. 14, p. 25-44, 2013.SANTOS, Émina. A educação como direito social e a escola como espaço protetivo de direitos: uma análise à luz da legislação educacional brasileira. Educação e Pesquisa, São Paulo, v. 45, p. 1-15, 2019.SANTOS, Júlio Ricardo Quevedo; ROCHA, Aristeu Castilhos da. Ensinar história e cultura afro-brasileira: possibilidades e alternativas de práticas pedagógicas. Fronteiras: Revista de História, Dourados, v. 18. n. 31. p. 68-98, jan. / jun. 2016.SANTOS, Sales Augusto dos. Políticas Públicas de promoção da igualdade racial, questão racial, mercado de trabalho e justiça trabalhista. Revista TST, Brasília, v.76, n. 3, jul./set., 2010.SANTOS, Rosenverck Estrela. O movimento negro e a luta pelas políticas de promoção da igualdade racial no Brasil. Kwanissa, São Luís, v.1, n.1, p.139-153, jan./jun., 2018.SANTOS, Sônia Querino dos Santos e; MACHADO, Vera Lúcia de Carvalho. Políticas públicas educacionais: antigas reivindicações, conquistas (Lei 10.639) e novos desafios. Ensaio: Avaliação de Política Públicas Educacionais, Rio de Janeiro, v. 16, n. 58, jan./mar., 2008.SAVIANI, Demerval. Entrevista. Revista Retratos da Escola, Brasília, v.8. n.15. p. 221-564, jul./dez., 2014.SAVIANI, Demerval. Políticas educacionais em tempos de golpe: retrocessos e formas de resistência. Roteiro, Joaçaba, v. 45, n. 25, p. 1-18, jan./dez. 2020.SILVA, Andressa Queiroz da; JÚNIOR, Maurício dos Santos Lopes. Lei nº 10.639/2003: educar para a diversidade. Revista Em Favor de Igualdade Racial, Acre, v. 2, n. 1, p. 30- 41, ago./jan., 2019.SILVA, Guilherme Henrique Gomes da. Um panorama das ações afirmativas em universidades federais do Sudeste brasileiro. Cadernos de Pesquisa, São Paulo, v. 49, n. 173, p. 184-207, jul./set. 2019.SILVA, Andressa Carvalho; OLIVEIRA, Paula Cristina Silva. Ressignificação da identidade negra em uma escola no Distrito de Sopa, Diamantina–MG. Olh@res, São Paulo, v. 3, n.1, p. 258-279, 2015.SILVA, Wilker Solidade; MARQUES, Eugenia Portela Siqueira. Educação e relações étnico-raciais: a Lei 10.639/03, a formação docente e o espaço escolar. Horizontes, Itatiba, v. 33, n. 2, jul./dez., 2015.SILVA, Robson de Souza. Direito educacional: Conceito, orientação e princípios na atividade dos Conselhos Estaduais de Educação. 2010. Disponível em: https://www.direitonet.com.br/artigos/exibir/6081/Direito-Educacional-Conceito-orientacao-e-principios-na-atividade-dos-Conselhos-Estaduais-de-Educacao. Acesso em: 29 de jun. 2020.SOUSA, Sandra Maria Zákia Lian. Avaliação da aprendizagem na legislação nacional: dos anos 1930 aos dias atuais. Estudos em Avaliação Educacional. São Paulo. v. 20. n. 44, p. 453-470, set./dez. 2009.SOUSA, Letícia Pereira de. Reserva de vagas na Universidade Federal de São João del-Rei: o perfil dos beneficiados pela Ação Afirmativa 2 em 2010. 2013. 240 f. Dissertação (Mestrado em Educação) – Programa de Pós-graduação em Processos Educativos e Práticas Escolares, Universidade Federal de São João Del-Rei, São João Del-Rei, 2013.THEODORO, Mário. À guisa de conclusão: o difícil debate da questão racial e das políticas públicas de combate à desigualdade e à discriminação racial no Brasil. In: THEODORO, Mário (Org.). As políticas públicas e a desigualdade racial no Brasil: 120 anos após a abolição. Brasília: IPEA, 2008, 180 p.VASCONCELOS, Mário Sérgio; GALHARDO, Eduardo. O programa de inclusão na UNESP: valores, contradições e ações afirmativas. Revista Ibero-Americana de Estudos em Educação, v. 11, n. 25, p. 285-306, maio, 2016. Disponível em: https://periodicos.fclar.unesp.br/iberoamericana/article/view/8553/5732. Acesso em: 18 mar. 2020.VELLOSO, Jacques. Cotistas e não-cotistas: rendimento de alunos da Universidade de Brasília. Cadernos de Pesquisa, Rio de Janeiro, v. 39, n. 137, p. 621-644, maio/ago., 2009.