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1

Di Giovangiulio, Renzo. « Osservazioni archeologiche sottomarine dal Lazio meridionale. Consegne e rinvenimenti ». Salduie, no 11-12 (31 décembre 2012) : 249–63. http://dx.doi.org/10.26754/ojs_salduie/sald.201211-126640.

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Se analizan las rutas, comercio y navegacion de la Costa sur del Lazio (Italia - Mediterráneo central) durante la época romana, republicana y alto imperial a través de las evidencias proporcionadas por el estudio de varios depósitos y colecciones que contienen dicho material.
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Toscano, Maurizio. « La red de los castillos de la provincia de Viterbo, Italia (siglos X-XV) ». Arqueología y Territorio Medieval 15 (16 octobre 2008) : 73–89. http://dx.doi.org/10.17561/aytm.v15i0.1495.

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La construcción de bases de datos georeferenciadas extensivas se ha revelado a menudo, en las últimas décadas, como elección estratégica eficaz al afrontar las problemáticas ligadas a la comprensión de las dinámicas de asentamiento bajomedievales, y en particular al fenómeno castrense. Aquí se presentan los primeros resultados de la aplicación de este enfoque al territorio del Alto Lazio. Tras una breve alusión a la problemática del contexto territorial y a los límites cronológicos impuestos a la investigación, se ofrece un primer esquema de las características cuantitativas y espaciales de la red, y se presentan algunas comparaciones con territorios limítrofes. La imagen de conjunto obtenida es la de una malla de ocupación articulada, nacida de un proceso de fundación/fortificación de los centros no lineal, y de un balance entre encastillamiento y descastillamiento de características peculiares, pero que al mismo tiempo se inserta en el cuadro que hasta ahora dibujan los análisis llevados a cabo sobre el territorio toscano y prefigura la existencia de un modo de asentamiento for tificado con carácter disperso, extendido desde la Toscana meridional al Alto Lazio.
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Masseti, Marco, Gloria Adinolfi, Rodolfo Carmagnola, Maria Cataldi et Luciano Marras. « Predatori esotici e prede nostrane nell’invenzione pittorica della Tomba dei Demoni Azzurri (V secolo) della necropoli di Monterozzi, a Tarquinia ». Aristonothos. Rivista di Studi sul Mediterraneo Antico, no 18 (18 juillet 2022) : 263–83. http://dx.doi.org/10.54103/2037-4488/18106.

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L’impiego delle più sofisticate tecniche di rilevamento delle antiche pitture murali, mediante imaging multispettrali con analisi multivariate hanno consentito la restituzione e l’elaborazione grafica virtuale della decorazione pittorica murale della Tomba dei Demoni Azzurri (450–430 a.C.) della necropoli di Monterozzi, a Tarquinia (Viterbo, alto Lazio). È stato così possibile analizzare il programma iconografico originariamente concepito per la tomba, che comprendeva scene di caccia cui partecipavano prede autoctone e predatori esotici fra cui alcuni felidi vicino-orientali e/o nordafricani il cui uso come ausiliari venatori sarebbe qui documentato per la prima volta. The use of the most sophisticated techniques for the detection of ancient wall paintings, by means of multispectral imaging with multivariate analysis, has enabled the restitution and virtual graphic elaboration of the pictorial wall decoration of the Etruscan Tomba dei Demoni Azzurri (450-430 BCE) of the Monterozzi necropolis in Tarquinia (Viterbo, upper Latium). It was thus possible to analyse the iconographic programme originally conceived for the tomb, which included hunting scenes involving indigenous prey and exotic predators, including Near Eastern and/or North African felids whose use as hunting auxiliaries is documented here for the first time.
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Brichetti, Pierandrea, et Nunzio Grattini. « Distribuzione, consistenza ed evoluzione delle popolazioni di cigno reale, Cygnus olor, nidificanti in Italia nel periodo 1980-2012 ». Rivista Italiana di Ornitologia 84, no 1 (20 mars 2015) : 29. http://dx.doi.org/10.4081/rio.2014.216.

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Storicamente, i primi casi di nidificazione di Cigno reale (<em>Cygnus olor)</em> in Italia sono stati accertati in Lombardia e Piemonte negli anni ‘60-’70 del secolo scorso, in seguito ad introduzioni iniziate negli anni ‘30-’40 nelle parti svizzere di alcuni laghi lombardi e continuate nei decenni successivi. La popolazione nidificante risulta attualmente concentrata nelle regioni settentrionali, dal Piemonte orientale alla fascia costiera alto-adriatica, dove si riproduce quasi il 90 % della popolazione nazionale; presenze più frammentate in Liguria, Trentino-Alto Adige, Toscana, Umbria, Lazio, Basilicata e Sardegna. All’inizio degli anni ‘80 del secolo scorso erano state stimate 20-35 coppie nidificanti in meno di 15 siti; di queste, l’80% si trovava in Piemonte e Lombardia. Le coppie sono aumentate a 25-45 nel 1987, poi a 300-500 nei primi anni del 2000, ed attualmente a 500-700 in oltre 150 siti, con un aumento di oltre il 900% rispetto ai valori iniziali. Questi dati confermano la fase di incremento ed espansione territoriale nota a livello europeo negli ultimi decenni. La colonizzazione di molti siti riproduttivi, localizzati in prevalenza nelle regioni settentrionali, è dovuta alla formazione di nuclei svernanti, cui fa seguito la formazione di coppie riproduttrici. Tale fenomeno ha interessato, seppur in misura più limitata, anche le regioni centro-meridionali, dove le osservazioni sono andate aumentando negli ultimi due decenni. Il Cigno reale nidifica a coppie isolate o localmente raggruppate in forma coloniale in zone umide naturali o artificiali, anche di modesta estensione, preferibilmente dal livello del mare fino a 300 m, con un’altitudine massima di 970 m s.l.m., rilevata in Trentino.
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Rossi, Marco, et Alessandro Rovetta. « Pittura in alto Lario fra XIII e XIV secolo ». Mélanges de l'Ecole française de Rome. Moyen-Age, Temps modernes 106, no 1 (1994) : 17–30. http://dx.doi.org/10.3406/mefr.1994.3349.

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Ramos-Fuentes, Germán A., Iván D. Melo-Lagos et Fernando J. Regino-Ubarnes. « Control repetitivo impar de alto orden de un rectificador monofásico : operación a frecuencia variable ». TecnoLógicas 19, no 36 (30 janvier 2016) : 63. http://dx.doi.org/10.22430/22565337.587.

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Los rectificadores de potencia controlados son dispositivos utilizados con el fin de minimizar la contaminación armónica producida en las redes eléctricas durante el proceso de conversión de la potencia. El objetivo es obtener una corriente de entrada sinusoidal en fase con el voltaje de la red. Aunque es extenso el uso del control Proporcional Integral en el lazo de corriente, no es posible lograr altos desempeños con estos compensadores. Por otro lado, el Control Repetitivo y el Control Resonante son técnicas mediante las cuales se logran resultados excepcionales. La desventaja de estas estrategias de control es la gran pérdida de desempeño en el sistema cuando la frecuencia de lared se desvía de su valor nominal. En este artículo, se propone el uso de un Controlador Repetitivo Impar de Alto Orden para el lazo de corriente del rectificador. Este controlador se diseña para obtener una señal sinusoidal de corriente y rechazar los armónicos impares introducidos en el sistema. Al atacar sólo los armónicos impares, el costo computacional de su implementación resulta muy similar al del controlador repetitivo convencional, con la ventaja de proporcionar robustez ante cambios en la frecuencia de la red. Los resultados experimentales muestran el alto desempeño del compensador aún cuando la frecuencia de la red se desvía del valor nominal de diseño.
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Mut, Alejandro, José Luis Guinot, Leoncio Arribas, Lorena Díez-Presa, María Isabel Tortajada, Miguel Ángel Santos, Josefa Samper, Paula Santamaría et Juan Bosco Vendrell. « Braquiterapia de alta tasa en el carcinoma escamoso de labio en estadios iniciales ». Acta Otorrinolaringológica Española 67, no 5 (septembre 2016) : 282–87. http://dx.doi.org/10.1016/j.otorri.2015.12.003.

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Ansini, Luca, et Benedetta Fani. « Il Setting di Cammino per giovani in messa alla prova. Un progetto pilota ». MINORIGIUSTIZIA, no 1 (septembre 2020) : 204–12. http://dx.doi.org/10.3280/mg2020-001019.

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Nel presente contributo viene descritto un progetto educativo pilota realizzato dalla Onlus "Setting in Cammino" in collaborazione con l'Ussm di Roma, la Regione Lazio e il Dipartimento di Scienze della Formazione dell'Università Roma Tre. Nell'ambito di tre progetti di messa alla prova comunitari (art. 28 Dpr 448/88), già in corso, è stata inserita un'esperienza educativa nel Setting di Cammino: 140 km a piedi lungo la Via Francigena del Lazio, da Bolsena a Roma, per complessivi sette giorni. I tre giovani sono stati accompagnati da due operatori con alta formazione e con specifiche competenze di aiuto nel Setting di Cammino: un pedagogista ed una psicoterapeuta, entrambi di orientamento analitico transazionale. La Regione Lazio ha finanziato il progetto e l'Università di Roma Tre è stata incaricata di effettuare una valutazione pedagogica. Infine, è stata realizzata una Giornata di Studi conclusiva con la presenza dei rappresentanti di tutte le istituzionali coinvolte. Nella premessa vengono sinteticamente descritti gli elementi e le dimensioni del Setting di Cammino, indicando i contesti di ricerca nei quali sono stati elaborati.
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Torres, Danilo, Miriam Lima-Illescas, Magaly Jiménez-Romero et Maribel Llanes-Serrantes. « Evaluación sagital de los labios en individuos con diferente patrón de crecimiento facial vertical : estudio retrospectivo en radiografías cefálicas laterales, Cuenca. » Odontología Activa Revista Científica 7, Esp. (11 novembre 2022) : 1–8. http://dx.doi.org/10.31984/oactiva.v7iesp..822.

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Introducción: Es importante el análisis de la posición de los labios ya que influye de la oclusión, la estabilidad de los dientes y por consiguiente en la estética facial. Objetivo: Evaluar el espesor de los labios en individuos de 18 a 45 años de edad, con diferente patrón facial vertical en radiografías cefálicas laterales del cráneo Métodos: Estudio observacional con enfoque correlacional, se evaluaron160 radiografías cefálicas laterales en formato digital usando una pantalla de 13,3 pulgadas mediante el software AutoCAD 2020. Se dividió en cuatro grupos de acuerdo al patrón facial vertical (S-N/G-Gn): Bajo, Medio Bajo, Medio Alto y Alto; y el espesor de los tejidos blandos de los labios, se midió en cuatro niveles; el grosor de la base del labio superior, grosor del labio superior, grosor del labio inferior y grosor de la base del labio inferior. Para el análisis estadístico se utilizó el test de Kruskal-wallis y la prueba post-hoc Tukey, con un nivel de confiabilidad del 95% (p<0,05). Resultados: Se observaron diferencias significativas en el grosor de la base del labio superior con el tipo facial (p=0,005) mostró una correlación baja y negativa (Rho de Spearman -0,177). De acuerdo al sexo solo para las mujeres fue significativo en el espesor base del labio inferior (p=0,047). Conclusiones: El grosor de la base del labio superior va disminuyendo a medida que incrementa el patrón facial vertical por otro lado en las mujeres el grosor de la base del labio inferior aumenta a medida que aumenta el patrón facial.
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Huaynate-Villalobos, Anadely, et Américo Alejandro Munayco-Magallanes. « Factores de riesgo asociados a fisuras no sindrómicas de labio y paladar en neonatos del Instituto Nacional Materno Perinatal, 2012 -2017 ». Revista Peruana de Investigación Materno Perinatal 8, no 2 (28 août 2019) : 11–23. http://dx.doi.org/10.33421/inmp.2019148.

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Objetivo. Determinar los factores de riesgo asociados a fisuras no sindrómicas de labio y paladar en neonatos del Instituto Nacional Materno Perinatal, durante el 2012 al 2017. Material y método. Estudio observacional, analítico, transversal y retrospectivo, en el que se evaluó historias clínicas de madres y neonatos, se registraron dos grupos; un grupo de casos conformado por 40 neonatos con fisuras no sindrómicas de labio y paladar y, un grupo control formado por 52 neonatos sanos. Resultados. Se encontró mayor presencia de fisuras no sindrómicas de labio y paladar en neonatos de sexo masculino (22,8%), dándose más en el año 2016, y el diagnóstico más frecuente fue fisura del paladar duro y del paladar blando con labio leporino bilateral (Q37.4) (19,6%). Además, se encontró que el presentar antecedentes aumenta ligeramente el riesgo de nacer con fisuras no sindrómicas de labio y paladar, y las gestantes que presentan edad materna de alto riesgo y no consumen ácido fólico tienen 1,228 y 4,891 más riesgo de desarrollar un bebé con fisuras de labio y paladar respectivamente. Conclusiones. Las fisuras de labio y paladar, se presentaron en mayor frecuencia en neonatos de sexo masculino, en el año 2016 y el diagnóstico de fisura de labio y paladar más frecuente el Q37.4, y los factores de riesgo asociados a fisuras no sindrómicas de labio y paladar fueron la edad materna y el no consumo de ácido fólico.
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González-Gallegos, Jesús Guadalupe, et Remedios Aguilar-Santelises. « Salvia tilantongensis (Lamiaceae), una especie nueva de la Mixteca Alta de Oaxaca, México ». Acta Botanica Mexicana 1, no 109 (1 octobre 2014) : 1. http://dx.doi.org/10.21829/abm109.2014.1145.

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Se describe e ilustra a Salvia tilantongensis como una especie nueva de la Mixteca Alta de Oaxaca, México. El taxon es similar en su morfología a Salvia fulgens y S. gesneriiflora. Se distingue de ambas por su corteza exfoliante, peciolos articulados en un engrosamiento del nudo, hojas más estrechas, brácteas florales de menor tamaño y de ápice más corto, pedicelos más largos durante la fructificación, los lóbulos del cáliz agudos y largamente aristados, lóbulo medio del labio inferior de la corola incurvado cóncavo, filamento y estilo más cortos, y rama inferior del estilo más larga. Además, difiere de S. fulgens por la ausencia de un par de papilas en la porción basal del tubo de la corola. También se provee de descripciones detalladas de S. fulgens y S. gesneriiflora.
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W. Lazio, T. Joseph, Jill Tarter et Peter R. Backus. « Megachannel Extraterrestrial Assay Candidates : No Transmissions from Intrinsically Steady Sources ». Symposium - International Astronomical Union 213 (2004) : 433–36. http://dx.doi.org/10.1017/s0074180900193660.

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This paper reports new, more sensitive observations of nine of the eleven extrastatistical signals in the Megachannel Extraterrestrial Assay (META). These extrastatistical signals had all of the expected characteristics of extraterrestrial transmissions, except that they did not repeat. Cordes, Lazio, & Sagan (1997) showed that this lack of repeatability could be explained by interstellar scintillation of intrinsically steady sources. We use their methodology and our observations to exclude the scintillation hypothesis at a confidence level of at least 97.8% (for the case of an intrinsically weak source) to a level in excess of 99% (if the source strengths are comparable to that favored by Cordes, Lazio, & Sagan 1997). We also demonstrate that gravitational microlensing cannot account for the initial detection of these candidates nor is microlensing likely to play a role in future SETI programs. We conclude that the META candidates do not reflect a large population of powerful beacons.
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Lombardo-Aburto, Esther. « La intervención del pediatra en el niño con labio y paladar hendido ». Acta Pediátrica de México 38, no 4 (30 juin 2017) : 267. http://dx.doi.org/10.18233/apm38no4pp267-2731435.

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Las malformaciones congénitas son defectos estructurales presentes en el nacimiento. Las fisuras labio-alvéolo palatinas tienen una alta incidencia que se presenta en uno de cada 750 recién nacidos vivos, por lo que están entre las malformaciones más frecuentes y mejor conocidas. El labio y paladar hendido son anomalías que comúnmente están asociadas y constituyen las malformaciones congénitas más frecuentes de la cabeza y el cuello. Se define como labio leporino o hendido, fisura labial o queilosquisis al defecto facial que involucra el cierre incompleto del labio, unilateral, bilateral o medial, generalmente lateral a la línea media. Se define como paladar hendido, palatosquisis, o fisura palatina al defecto palatino en la línea media que comunica con fosas nasales y cavidad oral.
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Calixto, Sanderson Dias, Thatiana Lopes Biá Ventura Simão, Fabrício Moreira de Almeida, Stella Schuenck Antunes, Nelilma Correia Romeiro, Warley de Souza Borges, Fernanda Oliveira das Chagas et al. « (R)-(+)-Lasiodiplodin isolated from the endophytic fungus Sordaria tamaensis exhibits potent antimycobacterial and anti-inflammatory activities in vitro and in vivo : a dual approach for the treatment of severe pulmonary tuberculosis ». Journal of Pharmacy and Pharmacology 74, no 3 (24 novembre 2021) : 446–57. http://dx.doi.org/10.1093/jpp/rgab165.

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Abstract Objectives This study aimed to evaluate endophytic fungi isolated from Tocoyena bullata and Humiria balsamifera plant species for their antimycobacterial and anti-inflammatory activities, focusing on severe pulmonary tuberculosis cases which are often associated with exacerbated inflammation. Methods Mycobacterium suspensions were incubated with the samples for 5 days. RAW 264.7 macrophages stimulated with LPS were also incubated with them for 24 h to assess the inhibition of inflammatory mediator production and cytotoxicity. C57BL/6 mice were infected with Mtb M299 and treated for 15 days with lasiodiplodin (Lasio). Key findings Endophytic fungus Sordaria tamaensis, obtained from T. bullata, was the most promising. Its ethanolic extract impaired mycobacterial growth with MIC50 (µg/ml): 1.5 ± 0.6 (BCG), 66.8 ± 0.1 (H37Rv) and 80.0 ± 0.1 (M299). (R)-(+)-Lasio showed MIC50 92.2 ± 1.8 µg/ml (M299). In addition, Lasio was able to inhibit NO, IL-1β and TNF-α production and was not cytotoxic for macrophages. M. tuberculosis-infected C57BL/6 animals treated by Lasio reduced the number of acid-fast bacilli, lung pathology, leucocyte influx and proinflammatory cytokine production in the lungs. The class IIa fructose 1,6-bisphosphate aldolase was the predicted hypothetical target of Lasio. Conclusions (R)-(+)-Lasio stood out as a promising anti-TB compound, exhibiting anti-inflammatory and antimycobacterial effects, as well as low cytotoxicity.
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SAGART, Laurent, William H. BAXTER, Laurent SAGART et William BAXTER. « Reconstructing Old Chinese uvulars in the Baxter-Sagart system (Version 0.99)' ». Cahiers de Linguistique Asie Orientale 38, no 2 (2009) : 221–44. http://dx.doi.org/10.1163/1960602809x00027.

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This paper discusses the reconstruction of uvular and labio-uvular stops in Old Chinese, originally proposed by Pan Wuyun. The following two improvements are proposed: (1) the Old Chinese non labialized voiced uvular stop evolved to Middle Chinese y- (???) rather than hj- (???) in Pan's theory (which implies that Middle Chinese y- has two sources in Old Chinese: *1- and *G-); (2) uvulars and labio-uvulars evolve to MC velars when preceded by a minor syllable. This explains why velars and uvulars frequently alternate in phonetic series. The article also explores the evolution of (labio)uvulars in the context of different prefixes.
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Dominguez Ratamoza, E. A., A. Arvizu Mondragón, F. Rojas Iñiguez, F. J. Mendieta Jiménez et J. Santos Aguilar. « Detección intradina en comunicaciones ópticas con modulación de fase binaria empleando un lazo de Costas en el dominio del procesamiento digital de señales ». Revista Mexicana de Física 67, no 2 Mar-Apr (15 juillet 2021) : 238–48. http://dx.doi.org/10.31349/revmexfis.67.238.

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Reportamos un lazo de Costas para demodulación de un campo óptico con modulación de fase binaria (BPSK). El lazo opera en el dominio del procesamiento digital de señales (DSP) como parte de un receptor digital coherente intradino. La implementación práctica de demodulación BPSK en el dominio óptico generalmente no es factible. Por ello, empleamos técnicas basadas en la digitalización a alta velocidad del observable eléctrico post-fotodetección y el lazo de Costas en DSP actúa sobre la señal digitalizada. Elegimos este lazo por ser una estructura óptima tanto de demodulación BPSK como de sincronización de portadora. Normalmente, los lazos de Costas para demodulación BPSK operan con una portadora con frecuencia mayor que la velocidad del bit. Sin embargo, como demostramos en este trabajo, este lazo también puede operar adecuadamente para una velocidad de bit mayor que la frecuencia de portadora (detección intradina). A lo mejor de nuestro conocimiento, el lazo de Costas en DSP para demodulación BPSK intradina es reportado por primera vez en este trabajo. Para el diseño del lazo de Costas intradino nos basamos en el modelo PLL equivalente de un lazo de Costas convencional. Con fines de comparación y evaluación del desempeño, implementamos en simulación, en primer lugar, un lazo de Costas tradicional y posteriormente uno intradino. Para nuestras simulaciones empleamos señales del mundo real (datos binarios y ruido aditivo) adquiridos mediante digitalización. Finalmente, se realizó la caracterización del lazo de Costas intradino empleando una señal eléctrica post-fotodetección digitalizada obtenida a la salida de nuestro receptor digital coherente. Se observó un desempeño muy cercano al obtenido mediante simulación.
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Fazrin, Ditha Nurul, et Iwan Sukoco. « Peran Media Sosial Instagram dalam Membangun Kesadaran berdonasi di Lazis Darul Hikam ». Jurnal Sosiologi USK (Media Pemikiran & ; Aplikasi) 15, no 1 (30 juin 2021) : 22–41. http://dx.doi.org/10.24815/jsu.v15i1.20343.

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This study aims to determine the social interaction of Lazis Darul Hikam and the community through Instagram social media and to find out the role of social media Instagram in building awareness of donation in Lazis Darul Hikam. The research uses symbolic interaction theory to photograph how people interact using social media, define the meaning of the symbols conveyed and ultimately lead to actions in this case giving donations. The method used is a qualitative method, the donor Lazis Darul Hikam, an active user of Instagram, is an informant in this study. The results showed that social media has the following roles: (1) Instagram is a medium for inter-institutional interaction with the community to introduce programs and reporting media, (2) Instagram social media is also able to build awareness of donations by collecting funds obtained through social media.AbstrakPenelitian ini bertujuan untuk mengetahui interaksi sosial Lazis Darul Hikam dan masyarakat melalui media sosial Instagram serta untuk mengetahui peran media sosial Instagram membangun kesadaran berdonasi di Lazis Darul Hikam. Penelitian menggunakan teori interaksi simbolik untuk memotret bagaimana masyarakat berinteraksi menggunakan media sosial, mendefinisikan makna dari simbol-simbol yang disampaikan dan akhirnya bermuara pada perbuatan dalam hal ini memberikan donasi. Metode yang digunakan adalah metode kualitatif, donatur Lazis Darul Hikam pengguna aktif Instagram menjadi informan dalam penelitian ini. Hasil penelitian didapatkan bahwa media sosial memiliki peran sebagai berikut: (1) Instagram menjadi media untuk berinteraksi antar lembaga dengan masyarakat untuk memperkenalkan program dan media pelaporan, (2) Media sosial Instagram juga mampu membangun kesadaran berdonasi dengan terkumpulnya dana yang didapatkan melalui media sosial
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Paucar Muñoz, Norma, Miriam Ortega López, Mario Téliz Meneses et Ronald Ramos Montiel. « Etiología, diagnóstico y tratamiento del labio, paladar y labio/paladar fisurado en neonatos y lactantes. Revisión de literatura ». Revista Científica Especialidades Odontológicas UG 6, no 1 (4 janvier 2023) : 37–55. http://dx.doi.org/10.53591/eoug.v6i1.1626.

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Introducción: Las hendiduras orofaciales, como el labio y paladar fisurado, son malformaciones congénitas más comunes, con una alta incidencia y prevalencia a nivel mundial. El tratamiento de las HO, inicia inmediatamente después del nacimiento, hasta la adolescencia, incluso hasta la edad adulta, mediante múltiples intervenciones pre-quirúrgicas, quirúrgicas y postquirúrgicas. Objetivos: El objetivo de este estudio fue evaluar mediante una revisión de literatura la etiología, diagnóstico y tratamiento de labio, paladar y labio/paladar fisurado en neonatos y lactantes. Materiales y Métodos: La literatura se seleccionó mediante una búsqueda en las bases de datos electrónicas: ScienceDirect, PubMed, SciELO, Google Scholar, y los informes de la Organización Mundial de la Salud (OMS), plataformas de American Chef Palate (ACPA) - Craniofacial Association Centers for Disease Control and Prevention, WebMD, y el portal de Información de Enfermedades Raras y Medicamentos Huérfanos. La búsqueda se restringió a artículos en inglés y español, publicados desde el año 2011 al 2021. Resultados: Después de aplicar los criterios de inclusión, en total se obtuvieron y revisaron 35 artículos. Se realizó la revisión de literatura de la etiología, diagnóstico y tratamiento del labio, paladar y labio/paladar fisurado en neonatos y lactantes. Conclusiones: Los autores consideran que la etiología principal del labio y paladar fisurado es desconocida; sin embargo, existen diversos factores de riesgo genéticos y no genéticos. El diagnóstico se realiza mediante la exploración ecográfica a las 20 semanas de vida intra-uterina, y es indispensable la coordinación de los equipos multidisciplinarios para garantizar los mejores resultados.
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Pujayanti, Bella Apryani, et Rohmawati Kusumaningtias. « IDENTIFIKASI 8 ASHNAF UNTUK MENDUKUNG AKUNTABILITAS LAZIS DALAM PENGENTASAN KEMISKINAN DI KECAMATAN PALENGAAN, PAMEKASAN ». Wacana Equiliberium (Jurnal Pemikiran Penelitian Ekonomi) 9, no 01 (28 juin 2021) : 01–16. http://dx.doi.org/10.31102/equilibrium.9.01.01-16.

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The purpose of this study was to identify 8 ashnaf to support LAZIS accountability in poverty alleviation in Palengaan District. The type of research used is qualitative research with a descriptive approach. The data in this study were obtained through interview, observation and documentation techniques. Sources of data used in the form of primary data sourced from interviews with the head of LAZIS, mustahik, muzakki, and local religious leaders, as well as secondary data from books, articles and journals. The results showed that there were only 4 groups of zakat recipients (ashnaf) identified in the LAZIS Panyeppen area, namely the indigent, the poor, amil, and fi sabilillah. In addition, from the results of the study it is also known that the distribution of zakat carried out by LAZIS Panyeppen has not fully helped the needs of the mustahik (the poor), this is because the nominal amount of zakat received by the poor is relatively lower than that received by other groups, so poverty in the Palengaan area has not been fully resolved.
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Battaglini, Elena. « The Sustainable Territorial Innovation of “Inner Peripheries”. The Lazio Region (Italy) Case ». International Studies. Interdisciplinary Political and Cultural Journal 19, no 1 (15 septembre 2017) : 87–101. http://dx.doi.org/10.1515/ipcj-2017-0006.

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This methodological, policy-focused paper firstly defines the concept of “sustainable territorial innovation” and its operationalisation according to the strategic objectives of Europe 2020. Statistical processing was based on 26 indicators, which helped to perform a multivariate analysis and allowed to identify ten groups of municipalities characterised in terms of the territorial sustainable innovation idea. Their GIS spatial distribution has led authors to combine them with the set of indicators proposed by the Italian Government in the UE Cohesion Policy 2014–2020 perspective. The paper also addresses the constraints and opportunities for urban and peri-urban policies within new scenarios.
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Munadi, Muhammad, et Muslimah Susilayati. « KINERJA LEMBAGA ZAKAT DALAM PEMBERDAYAAN UMMAT (Studi pada Web Dompet Dhuafa, Lazis NU dan Lazis Muhammadiyah) ». INFERENSI 10, no 2 (1 décembre 2016) : 289. http://dx.doi.org/10.18326/infsl3.v10i2.289-308.

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This paper aims to describe the performance of zakat organizations for global empowerment (umma). The subjects of the study are three zakat organizations namely Dompet Dhuafa (DD), Lazis Nahdlatul Ulama (LAZISNU) and Lazis Muhammadiyah (LazisMU). Qualitative approach using content analysis is used to analyse the Data. The official websitesof those three zakat institution are used as primary sources. The results showed that the performance of Dompet Dhuafa is distinguished for its detail in the preparation of the vision, mission, goals, programs and organizational structures.Dompet Dhuafa develops the main program then makes it into specific program in details. There is relationship between vision, mission and objectives to reach both the local and global performance. LAZISMU is distinctive in optimizing the website. It can be foundthrough the use of four languages on the website: Bahasa Indonesia, Arabic, English, and France.LazisNU has outlined its program not only in the management of zakat, but also the empowerment.
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Wicaksono, Aries. « Audit Sistem Informasi Akuntansi Siklus Pengeluaran pada PT. Lagio Furniture ». Binus Business Review 5, no 2 (28 novembre 2014) : 510. http://dx.doi.org/10.21512/bbr.v5i2.1009.

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Rapid technological developments make the whole thing easier. Many companies also take advantage of these technological developments. Similarly, the corporate accounting system that uses the benefits of information technology in the form of Accounting Information Systems (AIS). PT. Lagio Furniture is amanufacturing company that produces furniture for the premium class. Information system is an important part that helps the company's operations become more effective and efficient, therefore it is important for information systems running properly.This research aimed to audit the general control and applications control on the expenditure cycle accounting information system at PT. Lagio Furniture. This type of audit is audit around the computer. And then also collecting data through observation and interviews with relevant parties. Results of thereserarch is the expenditure cycle accounting information system at PT. Lagio Furniture was good. But there is still need to be improved in the control plan security, operational management control, and control inputs.
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Sakalian, Vladimir, Enrico Migliaccio, Franco Tassi, Danail Doychev et Georgi Georgiev. « New and interesting records of jewel and longhorn beetles from Abruzzo, Lazio and Molise National Park, Italy (Coleoptera : Buprestidae and Cerambycidae) ». Fragmenta Entomologica 52, no 1 (14 avril 2020) : 63–66. http://dx.doi.org/10.4081/fe.2020.412.

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The present article lists distributional data about 19 taxa, which are new records for the Abruzzo, Lazio and Molise National Park, respectively – 16 jewel and 3 longhorn beetles. Data about 4 Italian endemics (2 buprestids and 2 cerambycids) are listed, and the category of risk according to the Italian IUCN Red Lists is also indicated for each species (when available); among the listed species, 1 is Endangered, 1 is Near threatened and 27 are Least concern.
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Yamada, Chiaki, Noriyuki Kitai, Naoya Kakimoto, Shumei Murakami, Souhei Furukawa et Kenji Takada. « Spatial Relationships between the Mandibular Central Incisor and Associated Alveolar Bone in Adults with Mandibular Prognathism ». Angle Orthodontist 77, no 5 (1 septembre 2007) : 766–72. http://dx.doi.org/10.2319/072906-309.

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Abstract Objective: To examine if there was any correlation between the labio-lingual inclinations of the mandibular central incisor and the associated alveolar bone, and to investigate the labio-lingual position of the mandibular central incisor root apex in the associated cancellous bone in adults with untreated mandibular prognathism. Materials and Methods: High-resolution computed tomography images of the mandible were recorded in 20 adult patients with mandibular prognathism. The labio-lingual inclinations of a central incisor and its associated alveolar bone, the thickness of the associated cancellous bone, and the distance from the central incisor root apex to the inner contour of both the labial and lingual cortical plates were measured. Correlations and differences between the measured variables were tested for statistical significance. Results: The labio-lingual inclination of the central incisor significantly correlated with the labio-lingual inclination of the associated alveolar bone, the thickness of cancellous bone, and the distance from the central incisor root apex to the inner contour of the lingual cortical bone. The distance from the central incisor root apex to the inner contour of the labial cortical plate of bone was significantly smaller than that to the lingual cortical plate. Conclusions: In adults with untreated mandibular prognathism, when the mandibular central incisor was more lingually inclined, the associated alveolar bone was also more lingually inclined and thinner. The mandibular central incisor root apex was closer to the inner contour of the labial cortical bone than to the lingual cortical bone.
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Lucena, Rosangelina, et Kasandra Uzcátegui. « Prevalencia de hendidura labiopalatina ». Revista Vive 2, no 6 (1 septembre 2019) : 124–33. http://dx.doi.org/10.33996/revistavive.v2i6.33.

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Introducción: La hendidura labio-palatina es un defecto congénito, donde existe la separación del labio superior y fisura del maxilar, por la fusión incompleta de los procesos maxilares y naso-medial del embrión, que conduce a múltiples alteraciones. Objetivo: Determinar la prevalencia de hendidura labio-palatina en pacientes que acuden a la Asociación Valenciana, para la atención interdisciplinaria de pacientes con alteraciones cráneo-faciales, Valencia-Carabobo/Venezuela, en el período 2016-2017. Materiales y métodos: Se realizó una investigación de campo, descriptiva, con el apoyo de historias clínicas. Con una población de 93 pacientes y una muestra pertinente de 45 pacientes; plasmando la información en gráficos y cuadros por frecuencia y % simple. Resultados: La hendidura labio-palatina bilateral, se presenta con mayor frecuencia que la unilateral, puede ser derecha e izquierda; todas predominantes en el sexo masculino y en edades de 0- a 9 años. Conclusión: Esta alteración acarrea problemas estéticos, alimenticios, auditivos, respiratorios y foniátricos, que deben ser abordados por un grupo multidisciplinario. Cada vez su prevalencia es alta, lo que conlleva a crear instituciones especializadas, con carácter resolutivo, para dar respuestas rápidas, a las diferentes malformaciones cráneo-faciales.
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Latterini, Francesco, Walter Stefanoni, Alessandro Suardi, Vincenzo Alfano, Simone Bergonzoli, Nadia Palmieri et Luigi Pari. « A GIS Approach to Locate a Small Size Biomass Plant Powered by Olive Pruning and to Estimate Supply Chain Costs ». Energies 13, no 13 (1 juillet 2020) : 3385. http://dx.doi.org/10.3390/en13133385.

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The valorization of agricultural residues plays a fundamental role in renewable energy production. Particularly, the management of olive orchards in Lazio region generates a considerable amount of biomass that is currently unexploited, but it could represent a valid source of solid biofuel for energy production in the Lazio region (Italy). Using a Geographic Information System (GIS) approach entirely based on open source software, five suitable areas (A, B, C, D and E) have been selected as eligible for hosting and feeding a 1 MWe power plant. Harvesting and transportation costs were also calculated. The harvesting operation costs were EUR 96.79 Mgfm−1 in A, while they ranged from EUR 49.83 Mgfm−1 (E) up to EUR 56.51 Mgfm−1 (D) for the other sub-areas. Sub-area A showed also higher transport costs, EUR 21.55 Mgfm−1 while the same value ranged from EUR 14.75 Mgfm−1 (E) to EUR 16.59 Mgfm−1 (B) in the other sub-areas. However harvesting costs resulted higher than those reported in the literature, mainly due to the low pruning yield per surface unit, an aspect which is directly related to the olive grove’s management in the region where annual pruning is the usual practice. Future developments of the present study should encompass the social and environmental aspects of residual biomass supply chains herein proposed.
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D’Alfonso, Rossella, Maria Adelaide Marini, Lucia Frittitta, Roberto Sorge, Simona Frontoni, Ottavia Porzio, Luisa Marina Mariani et al. « Polymorphisms of the Insulin Receptor Subtrate-2 in Patients with Type 2 Diabetes ». Journal of Clinical Endocrinology & ; Metabolism 88, no 1 (1 janvier 2003) : 317–22. http://dx.doi.org/10.1210/jc.2002-020807.

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We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy). The allelic frequency of Gly1057Asp variant did not differ between diabetics (32.9%) and nondiabetic subjects, whatever their ethnicity was (35.8% and 33.7% from Lazio and Sicily, respectively). As compared with Gly/Gly subjects within each group, Asp/Asp individuals showed no differences in quantitative traits, including fasting insulin and C-peptide, and several indices of insulin sensitivity and secretion. Only one of the diabetic patients was heterozygous for the Leu647Val variant, and none of the control subjects carried this variant. This patient had three children who were also heterozygous for this variant. They were glucose tolerant, and their insulin sensitivity and insulin secretion indices were within the range of age-matched controls. We also analyzed IRS-2 function in fibroblasts from carriers of Gly1057Asp or Leu647Val variant. No defects in IRS-2 expression, insulin-stimulated phosphorylation, or binding to the p85 subunit of phosphatidylinositol 3-kinase were observed. These results strongly argue against a major role of IRS-2 polymorphisms in the pathogenesis of type 2 diabetes.
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Fontana, Panebianco, Picchianti-Diamanti, Laganà, Cavalieri, Potenza, Pracella, Binda, Copetti et Pazienza. « Gut Microbiota Profiles Differ among Individuals Depending on Their Region of Origin : An Italian Pilot Study ». International Journal of Environmental Research and Public Health 16, no 21 (23 octobre 2019) : 4065. http://dx.doi.org/10.3390/ijerph16214065.

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Background and aims: Microbiota heterogeneity among humans is mainly due to genetic background, age, dietary habits, lifestyle and local environments. In this study we investigated whether the gut microbiota profile of Italian healthy volunteers could differ based on their geographical origin. Materials and Methods: 16S rRNA gene sequencing was employed to analyze the gut microbiota of 31 healthy volunteers from three different Italian regions: Apulia (South), Lazio (Center) and Lombardy (North). Results: Differences in microbiota composition were detected when the study participants were grouped by their region of origin and when they were classified based on age classes (p-values < 0.05). Also species richness was significantly different both according to Italian Regions (median richness: 177.8 vs. 140.7 vs. 168.0 in Apulia, Lazio and Lombardy; p < 0.001) and according to age classes (median richness: 140.1 vs. 177.8 vs. 160.0 in subjects < 32, 32–41 and > 41 years; p < 0.001), whereas the Shannon index and beta diversity did not change. Conclusions: This study identified differences in the gut microbiota composition and richness among individuals with the same ethnicity coming from three different Italian regions. Our results underline the importance of studies on population-specific variations in human microbiota composition leading to geographically tailored approaches to microbiota engineering.
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Jelis Septiana, Nanda, et Dani Kusumastuti. « Business Development Service Through Lazis Partnership With Universities in Mentoring MSMEs in Purbalingga Regency ». Social Science Studies 2, no 4 (16 juillet 2022) : 296–316. http://dx.doi.org/10.47153/sss24.4062022.

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Indonesia is a country where most of yhe population is Muslim, where the potential for zakat funds is quite large so that it can be used as an alternative in minimizing existing poverty. With the obligtion of zakat, if can be used as a bridge to even out commonuty‟s economy, so that the gap between the rich and the poor will be reduced. We can pay zakat institutions, one of which is LAZIS Muhammadiyah, Purbalingga Regency. This institution itself was founded in 2002. During the course of the establishment of LAZIS Muhammadiyah, not only consumptive zakat funds were distributed to 8 groups of zakat recipients. However LAZISMU, Purbalingga also distributes and utiliez produvtive zakat for MSMEs who are joined with them form f Business Development Service through mentoring programs. Thus, this study aims to find out in more detail related to an assistance which will later be described in the formulation og the problem that the author has determined. The type of research in this research is field research. This research was conducted at LAZISMU, Purbalingga Regency with a descriptive-qualitative approach. Which descriptive it self describing and explaining the Business Development Service Through LAZIS Partenrship with Higher Education in Assisting MSMEs in Purbalingga Regency, this research was taken with data collection techniques in the form of observation, interviews, and documentation. The speakers are from the LAZIS, universitas, counterparts, and MSME actors. The results of research in the field related to Business Development Service through LAZIS Partenrship with Universities in Monitoring MSMEs in Purblingga Regency are as follows : (1)The effectiveness of the implementation of the Business Development Service. (2) Evaluation of the Business Development Service.
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Ciarini, Andrea, et Stefano Neri. « ‘Intended’ and ‘unintended’ consequences of the privatisation of health and social care systems in Italy in light of the pandemic ». Transfer : European Review of Labour and Research 27, no 3 (21 juillet 2021) : 303–17. http://dx.doi.org/10.1177/10242589211028458.

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This article analyses the long-term effects of privatisation and marketisation on the Italian regional health and social care systems. The research focuses on three Italian regions – Lombardy, Veneto and Lazio – which are representative of three different models of governance in these sectors. We examine the effects of privatisation and marketisation on the health and social care system by discussing how the regional health-care systems have managed the impact of the COVID-19 pandemic. We also shed light on the dramatic consequences of the pandemic crisis on employment levels and working conditions.
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Vozella, Federico, Agostina Siniscalchi, Manuela Rizzo, Tommaso Za, Giusy Antolino, Ugo Coppetelli, Alfonso Piciocchi et al. « Immunotherapy in Multiple Myeloma : Experience of the Multiple Myeloma Gimema Lazio Group ». Blood 132, Supplement 1 (29 novembre 2018) : 5634. http://dx.doi.org/10.1182/blood-2018-99-115463.

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Abstract Introduction .Treatment of multiple myeloma (MM) patients (pts) has radically changed over the last years following the introduction of next generation proteasome inhibitors (PI) and immunomodulatory derivatives (IMiDs). Despite the improvement of pts' outcome due to these drugs, MM remainsan incurable disease given its propensity for clonal heterogeneity and its complex interaction with the surrounding bone marrow microenvironment. Almost all pts eventually relapse despite their responses to PI, IMiDs or both. Recently, one further therapeutic option for MM patients is represented bydaratumumab, an anti-CD38 monoclonal antibody approved alsofor heavily pre-treated pts who have exhausted all other therapeutic options. Patients and Methods. We report the experience of the Multiple Myeloma GIMEMA Lazio Group in 50 relapsed/refractory MM pts treated with daratumumab as monotherapy. Twenty-nine pts (58%) were men and 21 (32%) women. According to the ISS,24 pts (48%) were ISS I, 11 (22%) ISS II, 7 (14%) ISS III and 8(16%)not evaluable. According toDurie& Salmon, 20 pts (40%) were 1 A, 2 (4%) 1 B, 12 (24%) II A, 1 (2%) II B,7 (14%) III A, 3 (6%) III B and 5 (10%) not evaluable. Isotype IgG-k was found in 21 pts (42%), IgG-λ in 13 (26%), IgA-k in 6 (12%), IgA-λ in 3 (6%), micromolecular k in 5 (10%) andmicromolecular λ in 2 (4%). Median age was 62.3 years (range, 43.1 - 85.7); 32 pts (64%) were refractory to the last line of therapy; 26 (52%) had previously received a stem cell transplant (13 single autologous, 12 tandem autologous and one an autologous followed by an allogeneic transplant). After a median follow-up from diagnosis of 54.5 months (range 1.0 - 203.0) and a median of 3 previous lines of therapy (range 2 - 8), pts received a median of 3 cycles (range 1 - 23) of daratumumab. Results.Forty-seven pts (94%) performed at least one cycle and were evaluable for response. The overall response rate was 74%; in particular, 2 pts obtained a CR (4.2%), 3 pts a VGPR (6.3%), 17 pts a PR (36.2%) and 15 pts a SD (32%), while 10 pts (21.3%) presented a PD. After a median follow-up of 5.3 months (range 1 - 31) ,24 pts(65%) were still in response and alive, one pt (5.8%) died in PR due to post-allograft GVHD and 12 (32%) experienced a PD (1 CR, 1 VGPR, 6 PR and 4 SD). Seven (19%) pts died and 30 (81%) are still alive. With regard to the 3 pts not evaluable for response, 2 died early and 1 has not yet completed the first cycle. The median time to response, duration of response, progression-free survival and overall survival were 1.5 months (range 1.0 - 6.0), 6.7 months (95% CI, 4.14 - 14.21), 5.7 months (95% CI, 3.26 - 13.75) and 22.5 months (95% CI, 11.6 - 36.1), respectively. Daratumumab was well tolerated; the most common adverse events, of any grade, were infections in 20 pts (42.0%) and anaemia in 21 pts (44.0%), which did not lead to treatment discontinuation. Infusion-related reactionswere observed in 7pts (14.8%), grade I-II (4 pts), grade III (3 pts). Conclusions.Daratumumab monotherapy is an effective strategy for heavily pre-treated and refractory pts with multiple myeloma, with a favorable safety profile. This treatment option needs to be considered for pts not eligible for combination therapy of daratumumab with bortezomib or lenalidomide, recently approved also in our country. Disclosures Vozella: Takeda Oncology; Amgen: Honoraria. Annibali:Celgene; Takeda; Amgen, Janssen Cilag: Honoraria. Caravita di Toritto:Johnson & Johnson: Other: Advisory Board, Travel and Accomodation EHA; Amgen: Other: Advisory Board; Bristol-Myers Squibb: Honoraria, Other: Travel and Accomodation EMN; Takeda: Other: Advisory Board; Celgene: Other: Advisory Board, Travel and Accomodation ASH, Research Funding. Foà:NOVARTIS: Speakers Bureau; JANSSEN: Other: ADVISORY BOARD, Speakers Bureau; CELGENE: Other: ADVISORY BOARD, Speakers Bureau; GILEAD: Speakers Bureau; AMGEN: Other: ADVISORY BOARD; INCYTE: Other: ADVISORY BOARD; CELTRION: Other: ADVISORY BOARD; ABBVIE: Other: ADVISORY BOARD, Speakers Bureau; ROCHE: Other: ADVISORY BOARD, Speakers Bureau. Petrucci:Takeda Oncology; Amgen; Celgene; BMS; Janssen Cilag: Honoraria, Other: Advisory Board.
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Sosa-Vesga, Cristian David, Laura Daniela Arenas-Camacho, Carlos Alfonso Moreno González, Francisco Javier Nazar-Meneses, Andrés Felipe Pimiento Macías, Diego Alejandro Téllez Gamarra et Carlos Enrique Ramírez Rivero. « Complicaciones postquirúrgicas en intervenciones correctivas de labio y paladar hendido en pacientes pediátricos de un hospital de tercer nivel en Bucaramanga, Colombia 2013-2016 ». Revista Médicas UIS 31, no 2 (21 août 2018) : 25–32. http://dx.doi.org/10.18273/revmed.v31n2-2018003.

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Introducción: las hendiduras orofaciales son las malformaciones congénitas de cabeza y cuello más frecuentes en el mundo, con gran importancia epidemiológica por su alto impacto sobre la calidad de vida de la población. Este impacto está dado en gran parte por la presencia de complicaciones postquirúrgicas, por lo que es importante conocerlas, con el fin de aplicar estrategias de prevención o de corrección temprana. Objetivo: identificar las principales complicaciones posquirúrgicas de la cirugía correctiva de labio hendido, paladar hendido o ambos, en un hospital de tercer nivel en Bucaramanga, Santander, Colombia. Materiales y métodos: estudio observacional descriptivo de corte transversal. Se obtuvo la información de los registros de historias clínicas médicas, de pacientes cuya intervención quirúrgica fue realizada durante el período de enero de 2013 a diciembre de 2016. Resultados: se obtuvieron registros de 55 pacientes. La presentación conjunta de labio y paladar hendido fue la anomalía craneoencefálica más frecuente (70,9%). La complicación más frecuente fue la fístula oronasal (23,9% de pacientes con compromiso del paladar), seguida por la dehiscencia de la herida quirúrgica (3,6%). Se encontró un mayor porcentaje de complicaciones postquirúrgicas en el sexo masculino. Conclusión: la complicación postquirúrgica de corrección de labio y/o paladar hendido más frecuente encontrada en la muestra fue la fístula oronasal. MÉD.UIS. 2018;31(2):25-32.
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Pinzari, Manuela, et Mario Pinzari. « Genus Pempeliella Caradja, 1916 and P. bayassensis Leraut, 2001 (Lepidoptera, Pyralidae) in Italy ». ZooKeys 854 (10 juin 2019) : 131–44. http://dx.doi.org/10.3897/zookeys.854.35351.

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Pempeliellabayassensis has been reported for the first time in Italy. This species has been confused with P.ornatella for a long time. Our study of the historical collections of Carlo Prola and Federico Hartig, and also newly collected materials from central Italy, allowed us to verify the presence of P.bayassensis in Italy. At present, this species is known only in central Italy (Lazio), where it coexists with P.ornatella and P.sororiella. We also provide information on the geographical distribution of the genus Pempeliella in Italy. In northern Italy we found P.ornatella and P.sororiella, and in the south (Puglia), P.sororiella. In Sardinia, P.matilella, which has been confused with Delplanqueiacortella in the past, coexists with P.sororiella.
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Fatmawati, Naning, et Indra Hidayatullah. « Analysis of Accounting Application of Zakat, Infaq and Shadaqah and Accountability in the Presentation of Financial Statements ». Muhasabatuna : Jurnal Akuntansi Syariah 3, no 2 (5 décembre 2021) : 15. http://dx.doi.org/10.54471/muhasabatuna.v3i2.1335.

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The performance of zakat, infaq, and shadaqah management institutions can be seen with fund accounting, namely the recording system and appearance of entities in accounting such as assets and liabilities which are grouped based on the benefits in each account. In this case, the accounting treatment of zakat, infaq, and shadaqah includes acknowledgment, recording, and presentation of financial statements of zakat, infaq, and shadaqah management institutions. The purpose of this study was to determine the application of accounting for zakat, infaq and shadaqah as well as accountability in the presentation of financial statements based on PSAK 109 and to determine the application of accountability in the presentation of financial statements at LAZIS Al-Haromain Kediri City Branch based on PSAK 101. This research is a descriptive qualitative research, in which the presentation and processing of data is carried out in a descriptive manner by focusing on the data obtained, but this research is not used to test hypotheses or not use hypotheses. Sources of data in this study came from primary data and secondary data. Data collection procedures by means of interviews, observation and documentation. The results of this study are that at the recognition and measurement stage, LAZIS Al-Haromain is not fully in accordance with PSAK 109, where LAZIS Al-Haromain has not fully determined the receipt of non-cash assets from donors using the fair value required by PSAK 109. So far, LAZIS Al-Haromain has not journalized This non-cash infaq shadaqah receipt has an impact on the balance in the components of the financial statements, including the balance sheet (statement of financial position), reports on the use of infaq funds, and notes to financial statements. And the distribution of cash infaq shadaqah so far has not been journalized because in the early stages of receipt of infaq and cash shadaqah it was not journalized so that up to the distribution stage it also could not be journalized and directly in the form of a distribution report only. And at the stage of amil's financial statements based on PSAK 109, LAZIS Al-Haromain is not fully compliant. The implementation of accountability by LAZIS Al-Haromain in the presentation of financial statements and reporting is almost in accordance with the indicators of honesty and legal accountability, process accountability, program accountability, and policy accountability and is based on PSAK 101.
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Charry, Ingid, Mónica lorena Aguirre, José jaime Castaño castrillón, Brenda juliana Gómez, Juliana Higuera, Gloria lucía Mateus, Diana Montes et Oscar alberto Villegas. « Caracterización de los pacientes con labio y paladar hendido y de la atención brindada en el hospital infantil universitario de manizales (Colombia), 2010./Study of clinical and epidemiological characteristics of patients with lip and palate treated in th ». Archivos de Medicina (Manizales) 12, no 2 (15 décembre 2012) : 190–98. http://dx.doi.org/10.30554/archmed.12.2.8.2012.

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Objetivo: El labio y paladar hendido es la malformación más común de cabeza y cuello en el medio colombiano, es una patología multifactorial determinada por alteraciones genéticas y ambientales. Se da en uno de cada 900 nacidos vivos afectando a varones en una mayor proporción. El objetivo del presente estudio es registrar las características sociodemográficas, clínicas y de tratamiento de 118 pacientes con labioy paladar hendido atendidos en el Hospital Infantil Universitario “Rafael Henao Toro” de la ciudad de Manizales (Colombia).Materiales y Métodos: Estudio de corte transversal en pacientes que asistieron a la clínica de labio y paladar en el mencionado hospital.Resultados: Se encontró frecuencia del sexo masculino en un 55,1%, un 51,7% procedente del área urbana y en su mayoría de los estratos III y IV, la frecuencia más alta se presentó para labio y paladar hendido grado III con 36,4%. El esquema de tratamiento más utilizado fue la palatorrafia (63,6%) y la queiloplastia (69,5%).Conclusiones: La caracterización de los pacientes con labio y Paladar Hendido indica predominio por los pacientes con diagnóstico de labio y paladar hendido Grado III, igual distribución entre géneros, procedencia urbana en los cuales el estrato IV cuenta con la mayor frecuencia. Cabe destacar la importancia de un diagnóstico oportuno además un tratamiento multidisciplinario, que cuente con apoyo personal además del quirúrgico que se verá reflejado en una buena evolución y calidad de vida de los pacientes. Background: Cleft lip and cleft palate is the most common malformation of the headand neck of our environment, is a multifactorial disease determined by genetic andenvironmental factors. It occurs in one in every 900 live births, affecting males at agreater rate, today’s advances in terms of proposed treatment from the multidisciplinaryapproach, starting with a strict evaluation by pediatric to ensure that patients are in theright conditions to initiate surgical procedures.Materials and Methods: A cross sectional study. We recorded demographic characteristics,clinical and treatment of 118 patients who attended the lip and palate clinicat Children’s Hospital University of Manizales.Results: We found more frequently in males 55.1%, 51.7% from the urban area andmost of the layers III and IV, the highest incidence is presented for cleft lip and palategrade III in 36.4% The most commonly used treatment regimen was palate surgeryand cheiloplasty.Conclusions: The characterization of patients with cleft lip and cleft palate indicatespredominance for patients with cleft lip and palate grade III, gender equality, urbanhometown strata IV which has the highest frequency. Remarkable the importance ofearly diagnosis also appropriate multidisciplinary treatment, that has support in additionto the surgical staff will be reflected in a good performance and quality of life of patients
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Dakskobler, Igor, et Livio Poldini. « Phytosociological analysis of noble hardwood forests (Ostryo-Tilienion platyphylli) in the Karst and its neighbouring regions (SW Slovenia) ». Hacquetia 20, no 2 (8 juillet 2021) : 327–72. http://dx.doi.org/10.2478/hacq-2021-0015.

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Abstract In SW Slovenia, at Gora under Železna Vrata and Petnik gorge near Branik – both on the northern edge of the Karst, in the collapse doline Orleška Draga at Sežana and under Brkinski Rob at the contact of the Karst and Brkini Hills, we conducted a phytosociological analysis of the stands whose tree layer is dominated by Tilia platyphyllos, T. cordata, Acer pseudoplatanus, Ulmus glabra, in places also Carpinus betulus and Ostrya carpinifolia, and classified them into three associations, Corydalido ochroleucae-Aceretum pseudoplatani, Paeonio officinalis-Tilietum platyphylli and Fraxino orni-Aceretum pseudoplatani. The latter was described as a new. Also new is a secondary large-leaved lime association Lamio orvalae-Tilietum platyphylli on the sites of montane beech forests (Lamio orvalae-Fagetum) in the Čepovan valley, at the contact of the Dinaric and sub-Mediterranean phytogeographical regions of Slovenia.
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Yaniasti, Ni Luh. « LAZIMKANLAH YANG BENAR, JANGAN SELALU MEMBENARKAN YANG LAZIM, KARENA YANG LAZIM TIDAK SELALU BENAR,SALAH KAPRAH DALAM PEMAKAIAN BAHASA INDONESIA ». Daiwi Widya 9, no 2 (17 janvier 2023) : 18–36. http://dx.doi.org/10.37637/dw.v9i2.1182.

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AbstractIndonesian language users in official forums are expected to use Indonesian in accordance with applicable rules, both in spoken and written form. In accordance with the reality, currently there are still uses of Indonesian that are not in accordance with the rules of good and correct Indonesian or also known as standard language. This study was expected to be able to broaden Indonesian speakers to gain knowledge and to understand the rules for using the Indonesian language properly and correctly. The method used in obtaining data was observation method with note-taking techniques. Furthermore, the data obtained were analyzed using descriptive qualitative interpretive analysis methods. Based on data analysis, it can be seen that in the use of Indonesian there are forms of language that are misguided, such as ambiguous/contaminated sentences, wrong diction, and wrong reasoning. In this regard, the author suggests that Indonesian language users must pay attention to and comply with good and correct Indonesian language rules to create a dignified language and be proud to use Indonesian in accordance with what is mandated by the 1945 Constitution, namely in chapter XV, article 36.Keywords: Misguided, Standard Indonesian
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Barone, Pier Matteo, Elizabeth Wueste et Richard Hodges. « Remote Sensing Materials for a Preliminary Archaeological Evaluation of the Giove Countryside (Terni, Italy) ». Remote Sensing 12, no 12 (24 juin 2020) : 2023. http://dx.doi.org/10.3390/rs12122023.

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A collaboration between the American University of Rome, the Municipality of Giove, and Soprintendenza Archeologia, Belle Arti e Paesaggio dellʼUmbria has resulted in an academic project aimed at a preliminary evaluation of a particular area along the Tiber river that straddles the border between Umbria and Lazio. Archaeological prospection methods, such as Unmanned Aerial Vehicle (UAV)-based remote sensing, ground-penetrating radar (GPR), and photogrammetry, have made it possible to better study the landscape with respect to not only the changes the area has undergone recently, but also its evolution during the Roman and Medieval periods, while keeping the main communication route represented by the Tiber river as its fulcrum.
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Di Pietro, Romeo, Marco Giardini, Duilio Iamonico, Giancarlo Tondi, Daniele Angeloni, Emanuela Carli, Michele Aleffi et al. « Floristic and coenological data from the travertine substrates of the SAC “Travertini Acque Albule (Bagni di Tivoli)” (Lazio Region – Central Italy) ». Plant Sociology 59, no 2 (30 décembre 2022) : 51–70. http://dx.doi.org/10.3897/pls2022592/05.

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During a phytosociological field-work campaign on the vegetation of the travertine outcrops, included in the Special Area of Conservation (SAC) “Travertini Acque Albule (Bagni di Tivoli)” (Central Italy), several taxa of particular interest were identified. Carex vulpina, Lolium apenninum, Onosma echioides subsp. angustifolia, Typha domingensis, T. laxmannii and Vicia pannonica subsp. pannonica are new for the Lazio administrative Region, while Ophrys illyrica and Zannichellia peltata are confirmed for the flora of this Region. For each of these taxa phytosociological samples describing the plant communities in which they were found are provided. New records for rare species were also reported for cryptogams such as Algae, Lichens and Mosses.
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Gastelbondo-Barragan, Walter, Rocco Tarantino-Alvarado et Sandra Maigualida Aranguren-Zambrano. « Metodología para el cálculo del nivel integrado de seguridad (sil), aplicada al caso : estudio de un sistema instrumentado de seguridad (sis) de nivel en calderas industriales de alta presión ». Respuestas 13, no 1 (6 mai 2016) : 19–31. http://dx.doi.org/10.22463/0122820x.551.

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En el presente trabajo se desarrolla la metodología para el cálculo del nivel integrado de seguridad en el lazo de nivel en una caldera industrial de alta presión. El Nivel Integrado de Seguridad (SIL), se obtiene a partir de la representación dinámica de la confiabilidad de cada uno de los elementos que hacen parte de la función instrumentada de seguridad, a través de la cual se obtiene la Probabilidad de Falla en Demanda, el cual es el parámetro fundamental para la determinación del Nivel Integrado de Seguridad de un Sistema Instrumentado de Seguridad.Palabras Clave: Confiabilidad; Nivel Integrado de Seguridad; Cadenas de Markov; Fallas; Sistema Instrumentado de Seguridad; Calderas Industriales.
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Rombolà, Pasquale, Giulia Barlozzari, Andrea Carvelli, Manuela Scarpulla, Francesca Iacoponi et Gladia Macrì. « Seroprevalence and risk factors associated with exposure to Leishmania infantum in dogs, in an endemic Mediterranean region ». PLOS ONE 16, no 1 (4 janvier 2021) : e0244923. http://dx.doi.org/10.1371/journal.pone.0244923.

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Canine leishmaniasis (CanL) is a zoonotic parasitic disease caused by Leishmania infantum in the Mediterranean area and transmitted by phlebotomine sand fly vectors. The domestic dog is the main reservoir host. The aim of this study was to assess the influence of different individual, environmental and spatial risk factors on the dog exposure to L. infantum and to estimate the seroprevalence among owned and kennel dogs, in the Lazio region (central Italy), where canine leishmaniasis is endemic. In the period 2010–2014, 13,292 sera from kennel and owned dogs were collected by official and private veterinarians. The presence of anti-Leishmania IgG was analysed by indirect fluorescent antibody test (IFAT), using a 1:80 titre cut-off. At the univariable analysis, CanL seropositivity was associated with sex, size, breed, coat length, living with other dogs and forest/semi-natural land cover. At the multivariable analysis, age, ownership and attitude were confirmed as risk factors, being more than 2 years old, owned, and hunting dogs at higher risk. Being a Maremma sheepdog was a protective factor. A true overall seroprevalence of 6.7% (95% CI: 6.2–7.2) was estimated in the whole population while 7.3% (95% CI: 6.8–7.8) was estimated in kennel dogs and 74.3% (95% CI: 70.8–77.6) in owned dogs. The role of kennels as a key component for CanL active and passive surveillance was also highlighted. This study confirmed the endemicity of CanL in the Lazio region and focused some factors that can influence the seropositivity of dogs in a Mediterranean region.
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Salazar Pérez, Juan Manuel. « Hacia una Ciudad de las Artes ». Bitácora Arquitectura, no 49 (24 janvier 2023) : 58–61. http://dx.doi.org/10.22201/fa.14058901p.2022.49.84597.

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Al investigar sobre el tema de su tesis, la Secretaría de Comunicaciones y Obra Pública (SCOP) en el Archivo de Carlos Lazo, ubicado en el Archivo General de la Nación, Juan Manuel Salazar Pérez halló un raro mensaje que Diego Rivera le dirigió a Carlos Lazo el 27 de noviembre de 1951. Permanecía inédito hasta hoy y aquí se da a conocer. ¿Por qué es raro y por qué violar su derecho a permanecer oculto, si así, al parecer, lo decidieron su remitente y destinatario? El breve recado es anómalo porque, en pocas y cortas palabras, el pintor propone al arquitecto algo extravagante.
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Granata, Francesco. « Dropshaft cascades in urban drainage systems ». Water Science and Technology 73, no 9 (1 février 2016) : 2052–59. http://dx.doi.org/10.2166/wst.2016.051.

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Dropshaft cascades are typical elements of sewer systems in steep urban catchment basins. The design of a dropshaft cascade, which is generally addressed as an optimization problem, also needs to consider the subsequent effects induced on the flow by the different elements of the cascade. Experimental research has been performed at the hydraulic engineering laboratory of the University of Cassino and Southern Lazio in order to investigate the basic flow patterns in a dropshaft cascade, with particular reference to energy dissipation and air entrainment. This research has shown that, regarding these aspects, a dropshaft cascade proved to be a more efficient solution of the single drop manhole with the same total drop height.
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Thomas, Teresa Fava. « Italian Diaspora in a Massachusetts Mill Town : Migration between Palestrina (Lazio), Italy, and Southbridge, Massachusetts ». Diasporic Italy : Journal of the Italian American Studies Association 1 (1 octobre 2021) : 24–42. http://dx.doi.org/10.5406/27697738.1.1.024.

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Abstract This article offers a transnational examination of the Italian diaspora community from Palestrina, Lazio, in Southbridge, Massachusetts between 1900 and 1945 that addresses the impact of education on the economic empowerment of Italian immigrants. Due to the labor shortage in the area, the assimilation of Italians was more effective and second-generation Italians remained in the public school system longer. This combination of factors created more economic mobility for both foreign-born and second-generation Southbridge Italians. Factors that contributed to this unique circumstance included the intense competition for labor between two factories, American Optical Company (AO) and Hamilton Woolen Mill. Both firms were among the first in Massachusetts to invest in workplace English education and citizenship programs. This educational investment had the goal of retaining and advancing entry-level workers into skilled level positions. Furthermore, AO encouraged the town to establish a high school in 1917 and made substantial contributions to the establishment of a trade school in 1927. The Italian community in Southbridge developed their own institutions to promote cohesiveness and assimilation via their own social, community, and citizenship groups. There was also an increase in entrepreneurship within the Southbridge Italian community. Assimilation and upward economic mobility for Italians in Southbridge began in the workplace.
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Sberna, Giuseppe, Eleonora Lalle, Maria Beatrice Valli, Licia Bordi, Anna Rosa Garbuglia et Alessandra Amendola. « Changes in the Circulation of Common Respiratory Pathogens among Hospitalized Patients with Influenza-like Illnesses in the Lazio Region (Italy) during Fall Season of the Past Three Years ». International Journal of Environmental Research and Public Health 19, no 10 (13 mai 2022) : 5962. http://dx.doi.org/10.3390/ijerph19105962.

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A descriptive analysis of common respiratory pathogens (CRPs) detected in nasopharyngeal swabs (NPSs) from hospitalized patients with influenza-like illness during the fall seasons of the past three years, 2019–2021, in the Lazio region, Italy, was conducted to assess whether or not CRP circulation changed because of COVID-19 during the fall season. The results observed in a total of 633 NPSs subjected to molecular diagnosis for CRPs by multiplex PCR assay during the autumn seasons (exactly from week 41 to week 50) were compared with each other. In 2019, in 144 NPSs, the more represented CRPs were rhinovirus/enterovirus (7.6%) and influenza A/B (4.2%). In 2020, 55 (21.6%) out of 255 NPSs resulted positive for SARS-CoV-2 and, except for one case of Legionella pneumophila, the CRPs detected were exclusively rhinovirus/enterovirus (4.7%). In 2021, among 234 NPSs, 25.6% resulted positive for SARS-CoV-2, 14.5% for respiratory syncytial virus (RSV), and 12.8% for rhinovirus/enterovirus. Compared with 2019, in 2020, CRP circulation was severely limited to a few cases; in 2021, instead, infections by RSV (detected also among adults), rhinovirus/enterovirus, and other respiratory pathogens were observed again, while influenza was practically absent. The comparison of the CRPs detected in the NPSs depicts a different circulation in the Lazio region during the last three fall seasons. CRP monitoring has a direct impact on the prevention and control strategies of respiratory infectious diseases, such as the non-pharmacological interventions implemented in response to the COVID-19 pandemic. Future studies should investigate the impact of specific interventions on the spread of respiratory infections.
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Calvani, M., D. Di Lallo, A. Polo, A. Spinelli, D. Zappalà et A. M. Zicari. « Hospitalizations for Pediatric Anaphylaxis ». International Journal of Immunopathology and Pharmacology 21, no 4 (octobre 2008) : 977–83. http://dx.doi.org/10.1177/039463200802100422.

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The aim of the study is to examine the epidemiology of anaphylaxis in hospitalized children in Lazio (Central Italy) and to evaluate the incidence and case fatality rate. We also verified the concordance of diagnosis between the Emergency Department and Ordinary Hospitalizations. In order to obtain these results, we reviewed all ICD-9 codes indicative of anaphylaxis in all primary and secondary diagnoses from 2000 to 2003 in all Emergency Departments, Ordinary Hospitalizations and Day Hospitals in Lazio. We then identified 203 ICD-9 diagnoses of anaphylaxis in children aged between 0 and 17 years. Anaphylactic shock (995.0) accounted for 109 (53.7%) of cases. Food anaphylaxis (995.60 onwards) accounted for 87 (43.0%) of cases. Food anaphylaxis was more frequent in the first years of life. In fact, it decreased from 12.5/100,000 resident children/year in the first year of life to 6.1/100,000 resident children/year in the first two years of life, and less than 3/100,000 resident children/year after the seventh year (p <0.001). Only 12.5% of cases of anaphylaxis diagnosed in Ordinary Hospitalizations were subsequently diagnosed by the Emergency Department as anaphylaxis. Moreover, only 42.3% of the diagnoses of anaphylaxis made in the Emergency Department were later confirmed during Ordinary Hospitalization. In the four years of study, one child died from anaphylaxis. Thus, mortality was 0.038 cases/100,000 resident children/year. In conclusion, the incidence of hospitalization was highest in the first years of life, during which food anaphylaxis accounted for most hospitalizations. The inconsistency of diagnoses between Emergency Departments and Ordinary Hospitalizations suggests the need to increase awareness of anaphylaxis among health workers.
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Zhao, Dan, Ling-Feng Kong, Takenori Sasaki et Qi Li. « Shell variations in the gastropod, Monodonta labio, in the North-western Pacific : the important role of temperature in the evolution process ». Journal of the Marine Biological Association of the United Kingdom 99, no 7 (24 juin 2019) : 1591–99. http://dx.doi.org/10.1017/s0025315419000481.

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AbstractMolluscan shells showing phenotypic variations are ideal models for studying evolution and plasticity. In north-eastern Asia, genetic and morphological diversity of the gastropod, Monodonta labio, were assumed to be influenced by both palaeoclimatic changes and current ecological factors. In this study, we examined spatial variations in shell shape of M. labio using general measurement and geometric morphometric analysis. We also investigated whether shell shape variation is best explained by environmental gradients or by genetic structuring, based on our prior molecular phylogeographic study. Two common morphological forms were observed among Chinese populations and in the adjacent Asian areas. Both the analyses revealed separation patterns in morphological variations of shell shape among the clades and populations. Environmental modelling analysis showed a significant correlation between shape variations and local maximum temperatures of the warmest month, indicating the role of natural selection in the evolution of this species. Data obtained in this study, combined with the cytochrome oxidase subunit I (COI) molecular phylogenetic data from the prior study, showed that morphological variations in M. labio were constrained by both local adaptation and phenotypic plasticity. We hypothesized that geographic separation by the Dongshan Landbridge was the first step towards its diversification, and that the temperature gradient between the East China Sea and South China Sea probably was the selective force driving the divergence of its morphological variations.
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Vinci, Giuliana, Sabrina Antonia Prencipe, Ada Abbafati et Matteo Filippi. « Environmental Impact Assessment of an Organic Wine Production in Central Italy : Case Study from Lazio ». Sustainability 14, no 22 (21 novembre 2022) : 15483. http://dx.doi.org/10.3390/su142215483.

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Growing awareness of environmental sustainability in the agri-food sector has enhanced the gradual shift toward less-impactful food and organic production systems. In 2021, nearly three million hectolitres of organic wine were produced which accounted for 6% of the whole wine production in Italy (50.2 million hectolitres); thus, registering an increase of almost 60% in the last three years. The economic and cultural importance attributed to Italian wine production worldwide represents a key factor to assess and reduce the environmental burdens associated with the activities of this industry. Furthermore, literature studies have highlighted consumer sensitivity for sustainable winemaking processed, and there is even a trend towards eco-friendly wines. In particular, the bottling stage has been identified as an impactful stage for the environmental performance of the wine life cycle. This study examined the environmental impact assessment of organic wine production in the Lazio region, by performing a “cradle-to-gate” approach according to the life cycle assessment (LCA) methodology. High-quality inventory data for one year of operation was obtained directly from the farming company, “Tenute Filippi” (Cori, Lazio, Italy), and the wine process considered the input from grape cultivation to the winery phases. In these regards, the study also provided an impact assessment for the primary packaging of a 0.75 L wine bottle, with contributions from the different life cycle stages. The results showed a total amount of greenhouse gas emissions (GHGs) of 1.1 kg CO2 eq, that are responsible for climate change. Referring to the individual production input, the primary packaging phase accounted for 55% of the total GHGs, with 0.86 kg CO2 eq per bottle, followed by agricultural fuel use for grape production and harvesting activities, with 0.30 kg CO2 eq. Building on these results, the study provides recommendations on the selection of the most significant and relevant indicators for the environmental life cycle impact assessment, thus, identifying possible hotspots in the wine sector.
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Ismanto et Aristejo. « Optimalisasi Keamanan Jaringan Menggunakan Metode Port Knocking Pada LAZIS Wahdah Jakarta ». Jurnal Teknik Informatika 7, no 1 (2 février 2021) : 40–48. http://dx.doi.org/10.51998/jti.v7i1.350.

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Abstract— Network security system is very important, because it relates to the security of resources in network, if the networksecurity system is weak, so people are not interested could be easy to attacks on the system, either to manipulate the data or changing the configuration of the network . In Lazis Wahdah has not made the block on port network systems, and used of modem Asymmetric Digital Subscriber Line (ADSL) in the network do not block the port. This is because the ADSL Modem just can do simple configuration and also not have features such as Router. Focusing on the issue, the use of methods Port Knocking on Mikrotik RB951UI-2ND is an appropriate way to improve network security system. With Port Knocking only IP address that corresponds to the rule or according to a predetermined Knock can access Mikrotik, while that does not comply with the rule will remain blocked. So Port Knockingmethod can improve the security system on the network at Lazis Wahdah Jakarta. Intisari— Keamanan sistem jaringan sangat penting, karena berkaitan dengan keamanan sumber daya yang ada padajaringan berupa data-data, jika system keamanan jaringan lemah,maka orang yang tidak berkepentingan dapat denganmudah melakukan serangan pada sistem tersebut, baik untuk melakukan manipulasi data atau merubah konfigurasi padajaringan. Di Lazis Wahdah Jakarta belum melakukan blok pada port system jaringan, dan penggunaan modem AsymmetricDigital Subscriber Line (ADSL) pada jaringaan tidak melakukan blok terhadap port, ini karena Modem ADSL hanya bisamelakukan konfigurasi sederhana dan juga tidak memilik ifitur seperti halnya Router. Berfokus pada masalah tersebut,penggunaan metode Port Knocking pada Mikrotik RB941-2ND merupakan cara yang tepat untuk meningkatkan sistemkeamanan jaringan. Dengan Port Knocking hanya IP Address yang sesuai dengan rule atau sesuai dengan Knock yang telahditentukan yang dapat mengakses ke Mikrotik, sementara yang tidak sesuai dengan rule akan tetap diblok. Sehingga metodePort Knocking dapat meningkatkan system keamanan pada jaringan Lazis Wahdah Jakarta.
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Corrao, Giovanni, Federico Rea, Mirko Di Martino, Rossana De Palma, Salvatore Scondotto, Danilo Fusco, Adele Lallo et al. « Developing and validating a novel multisource comorbidity score from administrative data : a large population-based cohort study from Italy ». BMJ Open 7, no 12 (décembre 2017) : e019503. http://dx.doi.org/10.1136/bmjopen-2017-019503.

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ObjectiveTo develop and validate a novel comorbidity score (multisource comorbidity score (MCS)) predictive of mortality, hospital admissions and healthcare costs using multiple source information from the administrative Italian National Health System (NHS) databases.MethodsAn index of 34 variables (measured from inpatient diagnoses and outpatient drug prescriptions within 2 years before baseline) independently predicting 1-year mortality in a sample of 500 000 individuals aged 50 years or older randomly selected from the NHS beneficiaries of the Italian region of Lombardy (training set) was developed. The corresponding weights were assigned from the regression coefficients of a Weibull survival model. MCS performance was evaluated by using an internal (ie, another sample of 500 000 NHS beneficiaries from Lombardy) and three external (each consisting of 500 000 NHS beneficiaries from Emilia-Romagna, Lazio and Sicily) validation sets. Discriminant power and net reclassification improvement were used to compare MCS performance with that of other comorbidity scores. MCS ability to predict secondary health outcomes (ie, hospital admissions and costs) was also investigated.ResultsPrimary and secondary outcomes progressively increased with increasing MCS value. MCS improved the net 1-year mortality reclassification from 27% (with respect to the Chronic Disease Score) to 69% (with respect to the Elixhauser Index). MCS discrimination performance was similar in the four regions of Italy we tested, the area under the receiver operating characteristic curves (95% CI) being 0.78 (0.77 to 0.79) in Lombardy, 0.78 (0.77 to 0.79) in Emilia-Romagna, 0.77 (0.76 to 0.78) in Lazio and 0.78 (0.77 to 0.79) in Sicily.ConclusionMCS seems better than conventional scores for predicting health outcomes, at least in the general population from Italy. This may offer an improved tool for risk adjustment, policy planning and identifying patients in need of a focused treatment approach in the everyday medical practice.
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