Thèses sur le sujet « Alpha4 integrins »
Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres
Consultez les 50 meilleures thèses pour votre recherche sur le sujet « Alpha4 integrins ».
À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.
Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.
Parcourez les thèses sur diverses disciplines et organisez correctement votre bibliographie.
Mutz, Diana. « Identifizierung von Bindungspartnern des cytosolischen Teils der [alpha]3-Integrin-Untereinheit [Alpha3-Integrin-Untereinheit] und die Aufklärung ihrer Rolle bei der Funktion des [alpha]3[beta]1-Integrins [Alpha3beta1-Integrins] ». [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2004/214/index.html.
Texte intégralBao, Wenjie. « Role of integrin signaling in cell proliferation and survival / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-394-9/.
Texte intégralNadif, Raja. « The in vivo role of integrin alpha7 in heart integrity and function ». Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492878.
Texte intégralRahman, Abdul. « Neonatale Alloimmunthrombozytopenie die Entwicklung von rekombinanten [alpha]II-1tnb[beta]3-Integrin-Isoformen [Alpha-IIb-Beta-3-Integrin-Isoformen] (HPA-1 Antigene) und funktionelle Untersuchung einer seltenen Punktmutation auf [beta]3-Integrins [Beta-3-Integrins] (Oea-Antigen) / ». [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968380859.
Texte intégralChakraborty, Arup R. « Differential expression of integrin [alpha]₃[beta]₁ and [alpha]₆[beta]₄ molecules on a panel of rat esophageal cell lines ». Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1131345357.
Texte intégralKacsinta, Apollo Daniel. « Determining Biological Effectors of alpha6 Integrin Cleavage ». Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193604.
Texte intégralParks, William. « Force activation of I domain containing and lacking integrins on live cells ». Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42695.
Texte intégralLaplantine, Emmanuel. « Interactions au niveau des domaines intracellulaires des sous-unites alpha3a, alpha6a et beta1a des integrines ». Paris 6, 2000. http://www.theses.fr/2000PA066262.
Texte intégralNollet, Eric A. « Integrin alpha6 Activity in Castration-Resistant Prostate Cancer ». Thesis, Van Andel Research Institute, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10289534.
Texte intégralAlthough castration-resistant prostate cancers no longer respond to anti-androgen therapies, the androgen receptor (AR) is still required to promote tumor survival. However, the signaling pathways downstream of AR that promote this survival are not well known. We recently identified an AR-dependent survival pathway whereby AR induction of integrin α6β1 and adhesion to laminin activates NF-κB/RelA signaling and Bcl-xL. This pathway acts in parallel with the PI3K/Akt pathway in Pten-null tumor cells such that combined inhibition of both PI3K and integrin α6β1 is required to effectively kill tumor cells adherent to laminin. However, PTEN-null castration-resistant tumors were not effectively killed by this combination. I discovered that BNIP3, a hypoxia-induced BH3-only, pro-mitophagic Bcl-2 family member, is induced by androgen in castration-resistant cells through integrin α6β1 and HIF1α. Furthermore, castration-resistant cells adherent to laminin were much more efficient at inducing autophagy in response to androgen. Androgen blocked the ability of the PI3K inhibitor PX866 to kill castration-resistant tumors, but this was reversed by loss of BNIP3. Although BNIP3 was dispensable for androgen-induced autophagy, its mitophagy function was required for BNIP3 to promote resistance to PX866. Thus, enhanced hypoxia signaling in cooperation with AR/α6β1/HIF1α signaling on laminin in castration-resistant cells drives the expression of BNIP3 and enhances autophagy, both of which contribute to PX866 resistance through induction of mitophagy.
Weiken, Claudia. « Kollagenrezeptor [alpha]2[beta]1-Integrin [Alpha-2-Beta-1-Integrin] auf humanen und tierischen Thrombozyten Heterogenität und ihre Bedeutung / ». [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=976077981.
Texte intégralZargham, Ramin. « [Alpha]8[beta]1 integrin and vascular injury : role of [alpha]8[beta]1 integrin in restenosis after balloon injury ». Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111876.
Texte intégralIn this work, a rat model of carotid angioplasty was used to mimic vascular injury in humans. alpha8beta1 integrin was downregulated in the tunica media concomitantly with loss of the contractile phenotype. In vitro study revealed that it is a differentiation marker of VSMCs. To test the functional significance of the association between alpha8 integrin and the VSMC phenotype, short interference RNA was deployed to silence the alpha8 integrin gene. alpha8 integrin gene silencing heightened VSMC migratory activity as well as modulation of the VSMC phenotype in favour of the noncontractile state. In addition, alpha8 integrin overexpression induced re-differentiation of VSMCs and attenuated their migratory activity. It is, therefore, suggested that alpha8 integrin overexpression after vascular injury might control VSMC migration and neointima formation. On the other hand, alpha8 integrin gene silencing led to a reduced growth rate, which indicated a dichotomy between VSMC migration and proliferation.
In the later stages of neointima formation, constrictive remodeling plays a major role in late lumen loss. Our data demonstrated that alpha8 integrin is upregulated in the neointima during constrictive remodeling with concomitant luminal narrowing. The importance of this finding was highlighted by results showing that alpha8 integrin was required for the VSMC contractile phenotype evoked by transforming growth factor-beta (TFG-beta) and TFG-beta-induced myofibroblastic differentiation of Rat1 fibroblasts. Thus, it appears that alpha8 integrin expression blockade might reduce contractile remodeling and late lumen loss. Although the mechanism of alpha8 integrin signaling is not yet clear, our findings demonstrate that the alpha8 integrin-induced contractile phenotype is blocked by RhoA inhibitors. Furthermore, alpha8 integrin and RhoA are co-immunoprecipitated, and alpha8 integrin gene silencing reduces RhoA activity. Hence, it is postulated that alpha8-RhoA signaling might be closely intertwined.
Altogether, these studies indicate that alpha8 integrin is a contractile marker of VSMCs and a negative regulator of VSMC migration. Therefore, forced alpha8 integrin expression may be applied to reduce neointima formation. However, alpha8 integrin upregulation during constrictive remodeling concomitant with late lumen loss suggest that it could be involved in lumen narrowing. It seems likely that in therapeutic strategies to reduce restenosis the timeline of interference might be very important. Therefore, alpha8 integrin gene silencing in the later stages of neointima formation might be beneficial.
Alemany, i. Boor Monica. « Domaines fonctionnels de l'intégrine plaquettaire (alpha)IIb(beta)3 ». Grenoble 1, 1995. http://www.theses.fr/1995GRE10023.
Texte intégralDydensborg, Anders Bondo. « Integrin [alpha]6A[béta]4 in colon cancer ». Thèse, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/4231.
Texte intégralDydensborg, Anders Bondo. « Integrin [alpha]6A[bêta]4 in colon cancer ». [S.l. : s.n.], 2006.
Trouver le texte intégralPawar, Sangita. « Regulation of Integrin Alpha 6 Cleavage in Cancer ». Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194296.
Texte intégralLeppert, Jan. « Identifizierung und Charakterisierung von Interaktionspartnern des Integrins [alpha]6[beta]4 [alpha-6-beta-4] ». [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=974508780.
Texte intégralDiCara, Danielle. « Targeting alpha v beta 6 integrin for cancer imaging ». Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522319.
Texte intégralMechai, Nadja. « Untersuchungen zur biologischen Funktion der [alpha]3-cytoplasmatischen [alpha-3-cytoplasmatischen] Domäne des [alpha]3[beta]1-Integrins [Alpha-3-Beta-1-Integrins] und deren Einfluss auf die Aktivierung der kleinen GTPasen Rac1 und RhoA in PC12-Zellen ». [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2005/27/index.html.
Texte intégralGeginat, Jens. « Interdependence between adhesion and proliferation the role of the [alpha]L- [alphaL-], [beta]2-integrin [beta2-integrin] (LFA-1) in t cell antigen receptor dependent proliferation of primary human t lymphocytes / ». [S.l.] : [s.n.], 1999. http://www.diss.fu-berlin.de/1999/35/index.html.
Texte intégralGhannad, Farzin. « Expression of alpha v beta 6 integrin in periodontal disease ». Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31758.
Texte intégralDentistry, Faculty of
Graduate
Ni, He-Hong. « Contribution of integrin [alpha]6[bêta]4 to colon cancer ». Thèse, Université de Sherbrooke, 2004. http://savoirs.usherbrooke.ca/handle/11143/4190.
Texte intégralNi, He-Hong. « Contribution of integrin [alpha] 6 [bêta] 4 to colon cancer ». Sherbrooke : Université de Sherbrooke, 2004.
Trouver le texte intégralWorst, Robinson André. « Influência da expressão da alfa-6 integrina na produção de células-tronco espermatogoniais murinas transgênicas ». Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-25042013-142427/.
Texte intégralThroughout the reproductive life of adult males, spermatozoa are formed from spermatogonial stem cells (SSCs) by a process known as spermatogenesis. The in vitro culture of SSCs created new possibilities for transgenesis, however the protocols require addition of growth factors, which increases the maintenance costs of these cells for a prolonged time, making of the cryopreservation of SSCs an alternative for this problem. The molecular phenotype of spermatogonial stem cells have been target of studies in recent decades. One of the most studied marker molecule in the characterization of spermatogonia is integrin alpha-6. Based on these informations, the following hypothesis was proposed: SSCs that show increased expression of integrin alpha-6 are more efficient for genetic modification and colonization of seminiferous tubules. In order to test this hypotesis, murine SSCs were dissociated from testes of 8 to 11 days old mice. These cells were in vitro cultured, characterized based on its morphology, frozen and incubated with anti-integrin alpha-6 antibody for the purification of SSCs by activated cell sorting fluorescence (FACS). Testicular cells were genetically modified with the insertion of the marker gene LacZ and transplantation through the efferent ducts was standardized. The testicular germ cells were dissociated and in vitro cultured, however viability was below expected, precluding the steps of transformation, transplantation and subsequent histological evaluation. Using molecular marker integrin alpha-6 it was possible to separate testicular germ cell populations by FACS and gene expression of ITGα6, GFRα1, Oct-4 and Thy-1was detected by quantitative RT-PCR. In conclusion, it was not possible to prove the efficiency of transduction and colonization in the seminiferous tubules by spermatogonial stem cells selected with alpha 6 integrin.
SKALSKI, MYLENE. « Integrines et developpement : expression et fonction des integrines alpha-v au cours du developpement chez l'amphibien pleurodeles waltl ». Paris 6, 1998. http://www.theses.fr/1998PA066338.
Texte intégralKünneken, Kerstin. « Rekombinante Mini-Laminin-5-Proteine zur Charakterisierung der 3 1-Integrin-Bindung [Alpha-3-Beta-1-Integrin-Bindung] ». [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967391334.
Texte intégralBrunton, Fiona. « Targeting the osteoclast alpha v beta 3 integrin by phage display ». Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511761.
Texte intégralMohazab, Leila. « The role of alpha v beta 6 integrin in enamel biomineralization ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45355.
Texte intégralStanco, Amelia Anton Eva S. « The role of [alpha]3[beta]1 integrin in cortical development ». Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1789.
Texte intégralTitle from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Neurobiology in the Curriculum of Neurobiology." Discipline: Neurobiology; Department/School: Medicine. On title page, [alpha] and [beta] appear as Greek characters.
Woodard-Grice, Alencia V. « Hyposialylation regulates [alpha]4[beta]1 integrin binding to VCAM-1 ». Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/woodard.pdf.
Texte intégralYEHIA, GHASSAN. « Analyse de la fonction de la chaine integrine alpha-6 chez la souris : role des deux isoformes alpha-6a et alpha-6b ». Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13243.
Texte intégralSONG, YUKUN SONG. « Stochastic Integrals with Respect to Tempered $\alpha$-Stable Levy Process ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1501506513936836.
Texte intégralVignoud, Lucile. « Étude du rôle des motifs NPXY dans la fonction de l'intégrine alpha 5/beta 1 ». Grenoble 1, 1996. http://www.theses.fr/1996GRE10274.
Texte intégralZimmermann, Dunja. « Der Einfluss cyclischer RGD-Peptide auf die Wechselwirkung Fibronectin-Integrin [alpha]5[beta]1[alpha 5 beta 1] ». [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970414277.
Texte intégralHook, Lilian Alexandra. « Roles of beta 1 and alpha 4 integrins in development of the definitive haemopoietic system ». Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/15048.
Texte intégralHeller, Kristin Noreen. « Alternative to Gene Replacement for Duchenne Muscular Dystrophy using Human Alpha7 Integrin (ITGA7) ». The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388401639.
Texte intégralPinco, Karen Ann. « In vivo and in vitro analyses of the functional role of alpha4 integrin in cell migration ». Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080746.
Texte intégralJacquelin, Béatrice. « Etude des bases moléculaires à l'origine des variations d'expression de la sous-unité alpha2 de l'intégrine alpha2beta1 ». Paris 7, 2001. http://www.theses.fr/2001PA077089.
Texte intégralNguyen, Beth P. « Integrin alpha 6 beta 4 ligation to laminin 5 and phosphoinositide 3-OH kinase define differences in alpha 3 beta 1-laminin 5 and alpha 2 beta 1-collagen spreading : implications for epidermal wound repair / ». Thesis, Connect to this title online ; UW restricted, 1999. http://hdl.handle.net/1773/9286.
Texte intégralMcCandless, John Richard 1954. « Alpha-6 beta-1 and alpha-6 beta-4 integrin expression and the vascularization of human prostate tumor xenografts ». Thesis, The University of Arizona, 1997. http://hdl.handle.net/10150/278603.
Texte intégralLiu, Chi-Chao. « Alpha-integrin expression and function modify chemoresistance and immunogenicity of acute lymphoblastic leukemia ». Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60560.
Texte intégralMedicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate
Sun, Guobin. « The role of protein tyrosine phosphatase alpha tyrosine 789 phosphorylation in integrin signaling ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43924.
Texte intégralCheng, Suzanne Yuen Shan. « The function of protein tyrosine phosphatase alpha (PTPα) phosphorylation in integrin-mediated signaling ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45615.
Texte intégralWray, Helen. « Characterisation of apoptotic responses in human keratinocytes expressnig alpha-6 integrin and CD44 ». Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/372.
Texte intégralRabinovitz, Isaac. « The role of alpha 6 integrin and its ligand, laminin, in prostate cancer ». Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187186.
Texte intégralSiller-Jackson, Arlene J. « Connexin 43 hemichannels are regulated by mechanical stress and [alpha]5 integrin in osteocyte-like cells : a dissertation / ». San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1400962241&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.
Texte intégralChang, Cheng. « Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer : A Dissertation ». eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/734.
Texte intégralWenke, Ann-Kathrin. « Die Rolle und Regulation von Integrin alpha10 bei physiologischen und pathophysiologischen Prozessen ». kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/943/.
Texte intégralQuinn, Jeffrey Alan. « Requirement of integrin [alpha]5[beta]1 and tyrosine phosphorylation of SHC for prohb-EGF release by GPR30, a seven transmembrane receptor for estrogen / ». View online ; access limited to URI, 2006. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3225328.
Texte intégralBroich, Kerstin. « Importance of [alpha]v[beta]3 [alpha-v-beta-3] integrin in arteriogenesis in the peripheral circulation of the rabbit ». Giessen : DVG-Service-GmbH, 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972754466.
Texte intégralEverding, Jens [Verfasser], et Michael J. [Akademischer Betreuer] Raschke. « Untersuchung des Einflusses von Integrin Alpha 2 Beta 1 auf den nativen Knochen im Alterungsprozess und die Frakturheilung anhand der Integrin-Alpha-2-Knock-out-Maus / Jens Everding. Betreuer : Michael J. Raschke ». Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2013. http://d-nb.info/1034311719/34.
Texte intégral