Thèses sur le sujet « Alkylamido »
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1
Lahiri, Amaresh Chandra. « Investigation on some : 2-Alkylamido-6-Bromo-4ft-1,3,2 - Benzodioxaphosphorin 2-Sulphide : having pesticidal activities ». Thesis, University of North Bengal, 1990. http://hdl.handle.net/123456789/1132.
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Dasgupta, Jhinuk. « Investigation on some 2-Alkylamido 6-chloro/Nitro-4H-1, 3, 2-Benjodi-oxaphosphorin-2 - Sulphides having pesticidal activities ». Thesis, University of North Bengal, 1988. http://hdl.handle.net/123456789/1130.
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Subra, Guy. « Optimisation de structures en série alkylamido-tempo en vue d'une amélioration de la relaxivité en milieu protéique ». Montpellier 1, 1996. http://www.theses.fr/1996MON13513.
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Bonsen, Eva. « Photokatalytischer Abbau von Ammoniak und Alkylaminen mit reinem und dotiertem TiO2 ». [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=961830662.
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Schneider, Marc. « Nouveaux antagonistes 5-ht2 : derives de l'(indolyl-1) alkylamine ». Université Louis Pasteur (Strasbourg) (1971-2008), 1991. http://www.theses.fr/1991STR13181.
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L'historique de la decouverte des recepteurs serotoninergiques et leur classification sont discutes dans l'introduction. La structure et les principaux effets fonctionnels du recepteur 5-ht#2 sont decrits dans le chapitre suivant. Une etude bibliographique des antagonistes 5-ht#2 fait apparaitre 3 elements essentiels pour une bonne affinite: une amine tertiaire et 2 systemes aromatiques, ou un systeme aromatique et un systeme riche en electrons pi delocalises, dont l'un peut etre qualifie de principal, et l'autre de secondaire. Nous avons etudie l'importance du systeme secondaire en ajoutant un noyau phtalimide en tant que centre actif aromatique secondaire a des structures qui en sont depourvues: les (indolyl-1) et (phenyl-2 indolyl-1) alkylamines. L'activite antagoniste des molecules a ete determinee a l'aide d'un modele pharmacologique in vitro specifiquement lie aux recepteurs 5-ht#2: l'agregation plaquettaire. Les molecules testees inhibent l'agregation potentialisee par la serotonine et induite par l'adp. L'introduction du groupe phtalimide n'a pas ameliore l'ic50 des molecules de depart (1-10 microm). Le remplacement du noyau tetrahydro-1,2,3,4 quinazolinedione-2,4 centre actif aromatique secondaire de la ketanserine (ic50: 0,014 microm), par des noyaux indole ou phenyl-2 indole conduit a des derives ayant des ic50 de 0,067 et 0,198 microm respectivement. Ainsi, le centre actif aromatique principal d'un antagoniste 5-ht#2 ayant 2 systemes aromatiques doit etre inclu dans une structure peu flexible comportant l'amine tertiaire
6
CHAYER, SAID. « Bioisosteres des 3-alkylamine pyridazines : synthese et proprietes inhibitrices de l'acetylcholinesterase ». Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13237.
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Les 3-aminoethylaminopyridazines, analogues structuraux de la minaprine, constituent une classe pharmacologique importante. En particulier, certaines d'entre elles facilitent la neurotransmission cholinergique et l'un d'entre eux est actuellement etudie chez l'homme, pour le traitement de la maladie d'alzheimer. L'objectif de cette these etait d'etudier plus particulierement les possibilites de remplacement du cycle pyridazine dans ces composes par d'autres systemes bioisosteres (pyridines, triazines, dihydrotriazines). La cible pharmacologique visee au cours de ce travail est l'acetylcholinesterase (ache), enzyme responsable de la degradation de l'acetylcholine. Ceci nous a amene a etudier plus en detail les proprietes oxydo-reductrices des triazines, en particulier l'aromatisation des dihydrotriazinones par deprotonation. D'autre part, la synthese des 3-aminopyridazines est rendue delicate du fait de la faible reactivite des intermediaires de synthese (3-chloropyridazines). L'introduction reversible d'un groupe cyano en position 4 sur de tels systemes augmente tres sensiblement leur pouvoir electrophile. Cette observation a permis de mettre au point une methode plus versatile (rapport stoechiometrique, conditions de reaction plus douces) des 3-alkylaminopyridazines. Au plan pharmacologique, nous avons obtenu un derive environ trois cent fois plus puissant que la minaprine comme inhibiteur de l'ache
7
Jasso, Alfredo Rosales. « Synthesis and mode of action of gem-dimethylated and alkylamino-s-triazines stabilisers in polyolefins ». Thesis, Manchester Metropolitan University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307589.
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Spelman, Kevin. « The extraction, stability, metabolism and bioactivity of the alkylamides in Echinacea spp ». Thesis, University of Exeter, 2009. http://hdl.handle.net/10036/86198.
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The fatty acid amides, a structurally diverse endogenous congener of molecules active in cell signaling, may prove to have diverse activity due to their interface with a number of receptor systems, including, but not limited to cannabinoid receptor 2 (CB2) and PPARγ. Select extracts of Echinacea spp. contain the fatty acid amides known as alkylamides. These extracts were a previously popular remedy relied on by U.S. physicians, one of the top sellers in the natural products industry and are currently a frequently physician prescribed remedy in Germany. In the series of experiments contained within, Galenic ethanolic extracts of Echinacea spp. root were used for the quantification, identification, degradation and bioactivity studies. On extraction, depending on the ratio of plant to solvent and fresh or dry, the data indicate that there is variability in the alkylamide classes extracted. For example the acetylene alkylamides appear to extract under different concentrations, as well as degrade faster than the olefinic alkylamides. In addition, the alkylamides are found to degrade significantly in both cut/sift and powdered forms of echinacea root. Human liver microsome oxidation of the major alkylamide dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide generate hydroxylated, caboxylated and epoxidized metabolites. The carboxylated metabolite has, thus far, shown different immune activity than the native tetraene isobutylamide. Bioactivity studies, based on cytokine modulation of the alkylamides have been assumed to be due to a classic CB2 response. However, the results of experiments contained herein suggest that IL-2 inhibition by the alkylamide undeca-2E-ene-8,10-diynoic acid isobutylamide, which does not bind to CB2, is due to PPARγ activation. These data, combined with data generated by other groups, suggest that the alkylamides of Echinacea spp. are polyvalent in effect, in that they modulate multiple biochemical pathways.
9
Park, Bongjin. « Single electron transfer in reactions involving alkyl halides with lithium alkylamide, lithium alkyl and lithium metal ». Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/27052.
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Ekcan, Ismail. « Metal complexes of selected 5-alkylamino-1,2-benzoquinone-2-oximes and their applicability in solvent extraction ». Thesis, London Metropolitan University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341731.
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Bénézech, Véronique. « Approche de la réceptologie des (alkylamino)imidazo[1,2-a]pyrazidines : Synthèse et évaluation d'un outil pharmacologique ». Montpellier 1, 1997. http://www.theses.fr/1997MON13512.
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Roman, Miguel Angel. « Synthesis of branched nucleosides and oligonucleotides containing flexible alkylamine linkers on the heterocyclic bases ». Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22797.
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The N3 position of thymidine was alkylated with different sized bromoalkyl phthalimide linkers in generally good yields, with no alkylation observed on the sugar ring. The free amino group, available after methylamine deprotection of the phthalimide linker, was protected with the levulinyl protecting group (e.g., 20). Branched 'Y'-shaped nucleic acids containing branching monomer 20 were synthesized using standard solid phase synthetic methodology and complexes of these branched nucleic acids with one and two mole-equivalents of linear complement dA$ sb{10}$ are investigated by thermal melting. At the branching point the levulinic amide exhibited poor lability to Letsinger's hydrazine solution and proved to be incompatible with the solid phase synthesis of branched nucleic acids. The primary amino group provided a handle which was used to extend the size of the linker incorporating a primary hydroxyl group at the site of levulinic protection (e.g., 37, 38). The levulinic ester showed much better lability to hydrazinolysis rendering it more compatible with the solid phase synthesis of branched nucleic acids. An extensive one and two dimensional NMR characterization of the functionalized nucleosides is reported.
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Wortham, Etienne. « Intercalation et échange ionique dans les oxydes de manganèse lamellaires. Formation de mésophases oxydes de manganèse-alkylamine ». Montpellier 2, 2000. http://www.theses.fr/2000MON20030.
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Les oxydes ternaires axmno 2 (a = li, na, k,) peuvent adopter diverses structures a tunnels, lamellaires et de type spinelle. Ces oxydes de manganese sont utilises pour leurs proprietes d'echange ionique et de tamis moleculaire, en catalyse, et comme materiaux cathodiques dans les batteries au lithium. Nous avons etudie la birnessite qui est un oxyde de manganese lamellaire hydrate comprenant des ions alcalins entre les feuillets formes d'octaedres mno 6. Les syntheses de la birnessite par voie sol-gel, par precipitation directe et par traitement hydrothermal sont decrites et comparees. L'intercalation d'alkylamines a longue chaine c nh 2 n + 1nh 2 (6 n 18) dans la birnessite a 298 k conduit a l'obtention de phases expansees dans lesquelles les ions alkylammonium sont arranges en monocouche interdigitee dans la region interfoliaire. En chauffant moderement cet arrangement subit une transition. La reduction partielle de la birnessite, par reaction avec un hydroxyde d'ion alcalin permet l'exfoliation de l'arrangement lamellaire. Les suspensions colloidales de l'oxyde de manganese peuvent subir des reactions de transfert d'electron avec l'aniline conduisant apres precipitation a un nanocomposite forme de feuillets mineraux encapsulant le polymere organique. La spectroscopie d'absorption des rayons x a ete utilisee pour caracteriser la birnessite de depart et de ses differentes phases obtenues par intercalation.
14
Revais, Catherine. « Etude du comportement d'un alkylamide : le N,N-di (2-éthyl hexyl) hexanamide en vue de son utilisation comme extractant pour le retraitement des combustibles nucléaires ». Grenoble 1, 1990. http://www.theses.fr/1990GRE10098.
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Les n,n-dialkylamides sont susceptibles de remplacer le phosphate de tributyle (tbp), extractant actuellement utilise pour le retraitement des combustibles nucleaires. Pour notre part, nous avons particulierement etudie un dioctyl hexanamide (doha): le di(2-ethyl hexyl) hexanamide. Les principaux avantages de ces molecules par rapport au tbp sont les suivants: 1) la simplification eventuelle du procede, en permettant de supprimer l'etape de reduction du plutonium lors de la partition u/pu; 2) la possibilite d'incineration totale du solvant. Les recherches que nous avons effectuees ont permis d'apporter des connaissances nouvelles sur la degradation thermique et radiolytique du solvant (di(2-ethyl hexyl)hexanamide 1m dans le dodecane). Nous avons realise une analyse qualitative et semi-quantitative du melange obtenu apres une irradiation simulee par bombardement electronique. Les principaux produits de degradation ont ete identifies. De plus, les gaz et les parties organiques volatiles engendres lors de l'irradiation ont ete egalement analyses. Le dosage precis de l'acide hexanoique forme a permis un meilleur suivi de la degradation thermique et radiolytique du solvant. D'autre part, nous avons aussi observe l'evolution de ses proprietes en tant qu'extractant: le test de desengagement de phase, ainsi que la mesure des coefficients de partage ont permis d'apprecier l'efficacite de cet amide dans le fonctionnement du procede de retraitement. L'influence de la presence de cations sur la formation de crasses d'interphases dans le milieu irradie a ete prise en compte. Ce doha semble donner, sur ce plan, de meilleurs resultats que le tbp
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Bae, Stacy S. « A HPLC/ESI-MS method developed and validated to evaluate the quantity, identity, and stability of the alkylamides in ethanolic extracts of Spilanthes acmella ». Greensboro, N.C. : University of North Carolina at Greensboro, 2007. http://libres.uncg.edu/edocs/etd/1411/umi-uncg-1411.pdf.
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Thesis (M.S.)--University of North Carolina at Greensboro, 2007.Title from PDF t.p. (viewed Oct. 18, 2007). Directed by Nadja B. Cech; submitted to the Dept. of Chemistry and Biochemistry. Includes bibliographical references (p. 68-71).
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Hofmann, Fabian [Verfasser], Dirk M. [Akademischer Betreuer] Guldi et Dirk M. [Gutachter] Guldi. « Self-Assembling Monolayers as Contamination Protection Evaluation of Adsorbed Alkylamine Films from ODACON F Emulsion / Fabian Hofmann ; Gutachter : Dirk M. Guldi ; Betreuer : Dirk M. Guldi ». Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1216333025/34.
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Cruz, Paula Barroso. « Atividade acaricida do extrato metanólico de Acmella oleracea (L.) R.K. Jansen (Asteraceae) e espilantol sobre Rhipicephalus microplus (Acari : Ixodidae) e Dermacentor nitens (Acari : Ixodidae) ». Universidade Federal de Juiz de Fora (UFJF), 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/4146.
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O objetivo do presente trabalho foi avaliar a atividade carrapaticida do extrato metanólico de Acmella oleracea e do espilantol sobre Rhipicephalus microplus e Dermacentor nitens. O extrato metanólico foi obtido através de maceração com metanol. Desse extrato, foi obtida uma fração diclorometano com 99% de espilantol (que pode ser considerado um composto puro), que também foi testada sobre larvas e fêmeas ingurgitadas de R. microplus e larvas de D. nitens. Para a avaliação da atividade sobre larvas, foi utilizado o teste de pacote de larvas modificados e o extrato metanólico e a fração diclorometano (99% de espilantol) foram testadas em concentrações de 0,2 a 50,0 mg/mL. No teste de tempo letal, também foi utilizado a técnica de pacote de larvas, o extrato metanólico foi usado na concentração de 12,5 mg/mL e a avaliação do percentual de mortalidade foi feita após 15, 30, 45, 60, 75, 90, 120 minutos e 24 horas. Nesse teste foi feito o cálculo de tempo letal 50% (TL50). O teste com fêmeas ingurgitadas foi feito apenas com R. microplus, sendo testadas concentrações de 25 a 200 mg/mL do extrato metanólico e concentrações entre 2,5 a 20,0 mg/mL para o espilantol. O extrato metanólico ocasionou mortalidade de 100% das larvas de R. microplus e D. nitens a partir de concentrações de 3,1 e 12,5 mg/mL, respectivamente. O espilantol resultou em mortalidade de 100% para larvas de R. microplus a partir da concentração 1,6 mg/mL e de 12,5 mg/mL para D. nitens. No experimento de tempo letal, a mortalidade foi de 100% para larvas de R. microplus e D. nitens após 120 minutos e 24 horas, com TL50 de 38 e 57 minutos. No teste com fêmeas, o peso da massa de ovos e percentagem de eclosão dos grupos tratados com concentrações iguais e/ou superiores a 50,0 mg/mL do extrato metanólico apresentaram redução significativa (p> 0,05) em relação ao controle, enquanto o espilantol provocou redução significativa do peso da massa de ovos e percentagem de eclosão em concentrações de 10,0 mg/mL e 2,5 mg/mL, respectivamente. As fêmeas tratadas com 200,0 mg/mL do extrato morreram antes de iniciar o processo de oviposição, resultando em eficácia de 100%, enquanto a melhor eficácia para espilantol foi de 92,9% na concentração de 20,0 mg/mL. Portanto, é possível concluir que o extrato metanólico da A. oleracea e o espilantol apresentam atividade acaricida sobre R. microplus e D. nitens.
We evaluate the acaricidal activity of Acmella oleracea methanol extract and spilanthol on Rhipicephalus microplus and Dermacentor nitens. The methanol extract was made through maceration with methanol. From this extract, a dichloromethane fraction with approximately 100% spilanthol was obtained and tested on R. microplus larvae and engorged females and D. nitens larvae. For evaluation against larvae, modified larvae test packages were used, and both methanol extract and the dichloromethane fraction were tested at concentrations of 0.2 to 50.0 mg/mL. The larvae package technique was also used in the lethal time (LT) test, with methanol extract at a concentration of 12.5 mg/mL and the mortality percentage assessment was made after 15, 30, 45, 60, 75, 90, 120 minutes and 24 hours. The lethal time calculation 50% (LT50) was performed in this test. The engorged female test was done with R. microplus only, at concentrations of 25 to 200 mg/mL for methanol extract and 2.5 to 20.0 mg/mL for spilanthol. The methanol extract caused 100% mortality of the R. microplus and D. nitens larvae at concentrations from 3.1 and 12.5 mg/mL, respectively. Spilanthol resulted in 100% mortality for R. microplus larvae at concentration from 1.6 mg/mL and 12.5 for D. nitens. In the lethal time essay using the methanol extract, the mortality rate was 100% for R. microplus and D. nitens larvae after 120 minutes and 24 hours with LT50 of 38 and 57 minutes. In the test of females, the egg mass weight and the hatching percentage of the groups treated with concentrations equal to and/or higher than 100.0 mg/mL of methanol extract showed significant differences (p> 0.05) while spilanthol causes significant reduction of the egg mass weight and hatching percentage at concentrations of 10.0 mg/mL and 2.5 mg/mL, respectively. Females treated with 200.0 mg/mL of extract died before starting the oviposition process, resulting in 100% effectiveness, while the best efficacy for spilanthol was 92.9% at concentration of 20.0 mg/mL. Thus we conclude that the methanol extract of A. oleracea and spilanthol present acaricide activity against R. microplus and D. nitens.
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Silva, Márcia Maria Fernandes. « Híbridos da montmorillonita-KSF contendo grupos alquiamina - Sintese, caracterização e aplicações adsortivas ». Universidade Federal da Paraíba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/7044.
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The sodium montmorillonite-KSF (KSF-Na+) was organically modified by intercalation reactions, ion exchange and silanization using amines and amino silanes. The solids were characterized by various techniques of X-ray diffraction, infrared spectroscopy, elemental analysis (CHN), thermogravimetry, scanning electron microscopy and nuclear magnetic resonance of 29Si and 13C. The solid chlorinated indicated the immobilization of 0.97 mmolg-1 of chlorine in the matrix KSF-Na+. The reaction of the solid precursor and chlorinated with diamines in aqueous solution and without solvent was more efficient with the molecule of ethylenediamine. Substrates containing a silanized aminosilanos with two nitrogens indicated 1.47 and 1.13 mmolg-1 groups immobilized on the matrix KSF-Na+, respectively. For reactions with increasing chain diamines (H2N ((CH2) nNH2) where n = 8, 9, 10 and 12) it was realized that nonildiamina showed better incorporation into the matrix KSF-Na+. The synthesis of solid dodecylamine saw the entry of a 2,12 mmolg-1 of organic groups, and the matrix applied to the retention of copper ions (II) with values of 115.0, 80.06, 71.16 and 62.26 mg g-1 at 303, 308, 313 and 318 K, respectively. For diamines (H2N ((CH2) nNH2) where n = 8, 9, 10 and 12) there was protonated by the set of characterizations the effectiveness of the reactions. The solid containing protonated dodecylamine (KSF-C12N+) was applied to the adsorption of the dye Remazol Brilliant Blue R 303, 313 and 323 K, other words, the adsorptive process followed the pseudo second order model. The maximum retention capacities were 27.28, 28.84 and 31.87 mg/g at temperatures of 303, 313 and 323 K, respectively, and the process is adjusted to the Langmuir model.
A montmorillonita-KSF sódica (KSF-Na+) foi organicamente modificada por reações de intercalação, silanização e troca iônica utilizando aminas e silanos aminados. Os diversos sólidos foram caracterizados pelas técnicas de difratometria de raio-X, espectroscopia na região do infravermelho, análise elementar (CHN), termogravimetria, microscopia eletrônica de varredura e ressonância magnética nuclear de 29Si e 13C. O sólido clorado indicou a imobilização de 0,97 mmolg-1 de cloro na matriz KSF-Na+. A reação do sólido precursor e clorado com as diaminas em meio aquoso e sem solvente foi mais eficiente com a molécula do etilenodiamino. Os suportes silanizados com aminosilanos contendo um e dois nitrogênios indicaram 1,47 e 1,13 mmolg-1 de grupos imobilizados na matriz KSF-Na+, respectivamente. Para as reações com diaminas de cadeia crescente (H2N ((CH)nNH2) onde n= 8, 9, 10 e 12) percebeu-se que nonildiamina apresentou melhor incorporação na matriz KSF-Na+. A síntese do sólido com dodecilamina houve a entrada de 2,12 mmolg-1 de grupos orgânicos, sendo a matriz aplicada na retenção de íons de cobre (II) cujos valores foram de 115,0; 80,06; 71,16 e 62,26 mg g-1 a 303, 308, 313 e 318 K, respectivamente. Para as diaminas (H2N ((CH)nNH2) onde n= 8, 9, 10 e 12) protonadas observou-se pelo conjunto de caracterizações a efetividade das reações. O sólido contendo dodecilamina protonada (KSF-C12N+) foi aplicado na adsorção do corante azul de remazol RN a 303, 313 e 323 K, ou seja, o processo adsortivo seguiu o modelo de pseudo segunda ordem. As capacidades máximas de retenção foram de 27,28; 28,84 e 31,87 mg/g nas temperaturas de 303, 313 e 323 K, respectivamente e o processo se ajustou ao modelo de Langmuir.
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Hajhassan, Houssein. « Synthese et etude de la structure et de proprietes de lipopeptides amphipatiques ». Orléans, 1987. http://www.theses.fr/1987ORLE2007.
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Des lipopeptides amphipathes ont ete synthetises : suivant la methode utilisee. On obtient des lipsamino-acides ou des lipopeptides ; etude par diffraction x, proprietes tensio-actives, pouvoir emulsifiant. Par le test d'hemolyse, il a ete montre que certains lipopeptides ont une hemocompatibilite similaire a celles des meilleurs tensio-actifs bicatenaires
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Laduranty, Joëlle. « Mise au point de la préparation de molécules polyfonctionnelles comportant l'unité structurale SCCN de la cystéamine : applications en radioprotection et synthèse organique ». Poitiers, 1988. http://www.theses.fr/1988POIT2013.
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Maddaluno, Jacques. « Synthèse énantiosélective de composés d'intérêt biologique : approche de polyols vicinaux par aldolisation stéréocontrôlée, approche de bêta-amino esters par addition de Michael stéréocontrôlée sous haute pression ». Paris 6, 1986. http://www.theses.fr/1986PA066240.
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La réaction d'aldolisation des benzoylaryacetates avec l'acétaldéhyde fait ressortir la capacité de ce synthon à effectuer un transfert d'asymétrie. Etude de la réactivité des alcoxy-3 acroléines. L'addition d'amines primaire sur des crotonates à haute pression permettent d'obtenir de meilleures sélectivités
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Tsai, Chih-Pin, et 蔡智斌. « Chemical Vapor Deposition of Tantalum Carbonitride and Tantalum Oxide Thin Films from Alkylamido Tantalum Complex ». Thesis, 1999. http://ndltd.ncl.edu.tw/handle/31631190922368428990.
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碩士國立交通大學
應用化學系
87
In this research, we used pentakis(ethylmethyl-amido) tantalum as precursor with different carrier gas (H2 and Ar) to deposit tantalum carbonitride thin film and with O2 as reactive gas to deposit tantalum oxide thin film by low-pressure chemical vapor deposition. The deposition temperature in our experiment was between 723 K~923 K and the base pressure is between 10-3~1 torr. The tantalum carbonitride films on the Si (100) substrate have yellow-gray color The grain size that was measured by SEM and AFM is small than 70nm. Then we used XRD to measure the microstructure of deposited films. At lower temperature 723 K, we could see diffraction pattern from XRD and know the polycrystalline thin films is cubic phase tantalum carbonitride. AES, ESCA and EPMA analysis revealed the composition of the films, we could show the composition as TaCxNyOz x = 0.42~0.91, y = 0.88~1.69, z = 0.07~0.34 , this is a carbon-rich thin films. When H2 was carrier gas, we can see highest carbon level in the films. Tantalum oxide was deposited on Si (100) by using O2 as a reactive gas. From the EPMA and ESCA analysis, we knew the film is Ta2O5 and contain much lower carbon and nitrogen level. The nitrogen contents is even lower than the limit of instrument. As evidenced by X-ray diffraction, an orthorhombic Ta2O5 was obtain in our experiment, and prefer to (100). Finally, we proposed the possible reaction mechanism based on the byproduct gas
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賈素娟. « Preparation and properties of polyoxyethylene alkylamine derivatives ». Thesis, 1990. http://ndltd.ncl.edu.tw/handle/82559328177962877779.
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郭木城. « Polymentization and surface activities of polyepichlorohydrin-alkylamine ». Thesis, 1988. http://ndltd.ncl.edu.tw/handle/46302746781741543850.
Texte intégral
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Chen, Ming-Hua, et 陳明華. « Synthesis and cytotoxicity of 6-alkylamino-2-substituted phenyl-4-quinolone derivatives ». Thesis, 2010. http://ndltd.ncl.edu.tw/handle/70300389449589386315.
Texte intégralRésumé :
碩士中國醫藥大學
藥物化學研究所碩士班
98
In our previous study , 2-(3’-methoxyphenyl)-6-alkylaminoquinolin-4-one (1) was identified as a potent cytotoxicity agents. Compound 1 was evaluated at a maximally tolerance dose with evidence of moderate antitumor activity. In order to search safer antitumor agents , a series of 6-alkylamino- 2-hydroxyphenyl-4-quinolone derivatives were designed and synthesized. Following published methods , 5-alkylamino-2-aminoacetophenone (4a-4c) were reacted separately with substituted benzoyl chloride (28-35) to yield the correspounding biaryl amide (36-44) which were subsequently cyclized in 1,4 dioxane in the presence of NaOH to give the correspounding substituted 2-phenylquinolin-4-one (45-53). Compounds (45-48、51) were catalytic hydrogenation or demethylated by HBr to afford the correspounding trarget compounds(54-57、60). The newly synthesized 6-alkylamino-2-hydroxyphenyl-4-quinolone dervatives (54-57、60) were evaluated for cytotoxicity against several human cancer cell lines. The structure-activity relationship was discussed. Preliminary results showed that 3’-hydroxy-6-morpholinyl-2-phenyl-4- quinolone (55a)、3’-hydroxy-6-pyrrolidinyl-2-phenyl-4-quinolone (55b) and 3’-hydroxy-6-dimethylamino-2-phenyl-4-quinolone (55c)have potent cytotoicity (IC50 values of 0.23-0.009 μM) against HL-60 leukemia cancer cell line with low toxicity against Detroit 551 normal human cell line. These target compounds will be used as new lead compounds for further evaluation.
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Lin, Li Husi, et 林麗惠. « Preparation and Surface Activity of polyoxyethylene alkylamine-maleic anhydride ». Thesis, 1993. http://ndltd.ncl.edu.tw/handle/57341535384478371991.
Texte intégralRésumé :
碩士國立臺灣科技大學
工程技術研究所
81
A series of amphoteric surfactants, including anionic and nonionic properties, has been synthesized by the rea- ction of polyoxyethylene alkylamine, maleic anhydride and sodium hydrogen sulfite. NMR, FTIR and element analysis have been used to con- firm the structure of these compound. These surfactants have been found to exhibit excellent surface active pro- perties including reducing surface tension, low-foaming and improving the dyeing abilities in direct dye-cotton dyeing system.
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Syh, Lee Jeng, et 李徵賜. « Preparation and Surface Activities of anionic modified polyoxyethylene Alkylamine surfactants ». Thesis, 1994. http://ndltd.ncl.edu.tw/handle/28198448833838097486.
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Cheng-TseWang et 王振擇. « Self-Assembled Behavior and Electrochemical Characteristics of Alkylamine on Au(111) Surface ». Thesis, 2015. http://ndltd.ncl.edu.tw/handle/04777280781683094898.
Texte intégralRésumé :
碩士國立成功大學
化學工程學系
103
The interfacial properties between the substrate and the deposited film are the major determinants of film construction. In this study, Cyclic voltammetry (CV) and electrochemical scanning tunneling microscopy (EC-STM) were used to study the alkyl amine molecules self-assembly behavior. This study reveals the R-NH2 molecules will form an adsorption pattern with highly regular “ lie down “ shape on Au(111) surface, even in an extreme acid system (pH = 1), the R-NH2 to gold atom binding will not break, only the outer layer R-NH2 will be protonated to R-NH3+ by acid electrolyte and the appearance of R-NH3+ will change when Au(111) electrode’s potential shifts to negative site. By In-situ method to proceed the in time observation, the study result shows a unique “ transform ” behavior of R-NH3+ to R-NH2 when the Au(111) electrode’s potential shifts to more positive site (0.6~0.8 V) from negative site (0.1V). This transform model was confirmed by EC-STM and X-ray Photoelectron Spectroscopy (XPS), once the R-NH2 adsorption structure is formed, the potential operation will not dismiss this adlayer.
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FAN, SHENG-CHIEH, et 范盛傑. « Multi−component synthesis of (3E)−7−dimethylamino−3−[alkylamino(aryl)methylidene]chroman−2,4−diones and their photochromic properties ». Thesis, 2017. http://ndltd.ncl.edu.tw/handle/94568178148838454477.
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Hsiao, Ying-Hsiu, et 蕭瑛 ? « Synthesis and Characterization of Polyamides and Polyimides with Main-chain Triphenylamine Units and Pendent Alkylamine Groups ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/92496100780445604302.
Texte intégralRésumé :
碩士大同大學
化學工程學系(所)
96
This thesis consists of two parts. The first part deals with the syntheses and characterization of novel aromatic poly(amine-amide)s and poly(amine-imide)s with 4-piperidinotriphenylamine [(Pi)TPA] units in the backbone from a newly synthesized diamine monomer, 4,4’-diamino-4”-piperidinotriphenylamine, which was synthesized via the cesium fluoride-mediated N,N-diarylation of 4-piperidinoaniline with 4-fluoronitrobenzene, followed by palladium-catalyzed hydrazine reduction of the intermediate dinitro compound. Amorphous and organosoluble poly(amine-amide)s were prepared by the phosphorylation polyamidation of the newly synthesized diamine monomer with various aromatic or aliphatic dicarboxylic acids. Poly(amine-imide)s were prepared from the diamine monomer with various aromatic dianhydrides via a conventional two-step procedure that included a ring-opening polyaddition to form poly(amic acid)s, followed by thermal or chemical cyclodehydration. All poly(amine-amide)s were readily soluble in polar organic solvents and could be solution cast into tough and flexible films. All the polymers showed high glass-transition temperatures (Tg) between 252-318 °C, and they were fairly stable up to a temperature above 400 °C [for poly(amine-amide)s] or 500 °C [for poly(amine-imide)s]. These polymers exhibited UV absorption maxima around 296-366 nm. The photoluminescence spectra of these polymers in N-methyl-2-pyrrolidone (NMP) solution (10-5 M) exhibited a blue light emission at 387-449 nm with a fluorescence quantum yield (ΦF) up to 3.57 %. The hole-transporting and electrochromic properties are examined by electrochemical and spectroelectrochemical methods. Cyclic voltammograms of the poly(amine-amide) films cast onto an indium-tin oxide (ITO) coated glass substrate exhibited two reversible oxidation redox couples at 0.44-0.49 and 0.80-0.88 V versus Ag/AgCl in acetonitrile solution. Most of these poly(amine-amide) films revealed excellent stability of electrochromic characteristics, with a color change from colorless or pale yellowish neutral form to green and blue oxidized forms at applied potentials ranging from 0.00 to 1.20 V. The polymer films showed reversible electrochemical oxidation accompanied by strong color changes with high coloration efficiency, high contrast ratio, and rapid switching time. The optical transmittance change (Δ%T) at 636 nm between the neutral state and the fully oxidized state is up to 83 %. The polymers also displayed low ionization potentials as a result of their (Pi)TPA moieties. Cyclic voltammograms of the poly(amine-amide) films on the indium-tin oxide (ITO)-coated glass substrate exhibited a pair of reversible oxidation waves with very low onset potential of 0.27 V (vs. Ag/AgCl) in acetonitrile solution. The second part deals with the syntheses and characterization of novel aromatic poly(amine-amide)s and poly(amine-imide)s with 4-morpholinotriphenylamine [(Mo)TPA] units in the backbone from another newly synthesized diamine monomer, 4,4’-diamino-4”-morpholinotriphenylamine, which was synthesized via the cesium fluoride-mediated N,N-diarylation of 4-morpholinoaniline with 4-fluoronitrobenzene, followed by palladium-catalyzed hydrazine reduction of the dinitro intermediate. All poly(amine-amide)s were readily soluble in polar organic solvents and could be solution cast into tough and flexible films. All the polymers showed high glass-transition temperatures (Tg) between 260-313 °C, and they were fairly stable up to a temperature above 450 °C [for poly(amine-amide)s] or 550 °C [for poly(amine-imide)s]. These polymers exhibited UV absorption maxima around 295-372 nm. The photoluminescence spectra of these polymers in N-methyl-2-pyrrolidone (NMP) solution (10-5 M) exhibited a blue light emission at 376-452 nm with a fluorescence quantum yield (ΦF) up to 4.85 %. The hole-transporting and electrochromic properties are examined by electrochemical and spectroelectrochemical methods. Cyclic voltammograms of the poly(amine-amide) films cast onto an indium-tin oxide (ITO) coated glass substrate exhibited two reversible oxidation redox couples at 0.50-0.56 and 0.87-0.93 V vs. Ag/AgCl in acetonitrile solution. Most of the poly(amine-amide) films revealed excellent stability of electrochromic characteristics, with a color change from colorless or pale yellowish neutral form to green and blue oxidized form at applied potentials ranging from 0.00 to 1.20 V. The polymer films showed reversible electrochemical oxidation accompanied by strong color changes with high coloration efficiency, high contrast ratio, and rapid switching time. The optical transmittance change (Δ%T) at 650 nm between the neutral state and the fully oxidized state is up to 90 %. The polymers also displayed low ionization potentials as a result of their (Mo)TPA moieties. Cyclic voltammograms of the poly(amine-amid)e films on the indium-tin oxide (ITO)-coated glass substrate exhibited a pair of reversible oxidation waves with very low onset potential of 0.36 V (vs. Ag/AgCl) in acetonitrile solution.
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Li, Ying-Hsuan, et 李映璇. « I. Study on the gland of Myocastor coypus by GC-MS AnalysisII. Study on the Preparation of N-[(3-Alkylamino)-propyl]norglaucine ». Thesis, 2004. http://ndltd.ncl.edu.tw/handle/77999273175695423538.
Texte intégralRésumé :
碩士國立臺灣大學
藥學研究所
92
Abstract Part I. Study on the gland of Myocastor coypus by GC-MS Analysis Part II. Study on the Synthesis of N-[(3-Alkylamino)-propyl] norglaucine Part I. Study on the gland of Myocastor coypus by GC-MS Analysis Musk, which is favorably used in the manufacture of perfume, is an important drug in Traditional Chinese Medicine. To obtain the musk, generally the gland producing musk was picked after killing the male deer (Moschus moschiferu L.). Wide use of this substance has forced the species standing on the verge of extinction. In Taiwan, the gland from nutria (Myocastor coypus) has been applied as less cost and more reproductive resource to replace musk. Hence, chemical analysis of the nutria gland was performed here to evaluate the feasibility as a substitute for musk. GC-MS coupled with MS data library is mostly used to analyze volatile substances. Therefore, we applied this technique with optimal temperature program to identify the components of the nutria gland secretion or the gland extract. Six authentic samples as standards were subjected to the same GC-MS system to confirm the major components and distinguish structural isomers. This study discloses that long-chain fatty acid esters, C10 and C15 terpenoid esters are the major components, the latter being the perfume substances. The minor constituents were also studied after removal of the major substances by saponification. Under analysis with the same condition, some cholesterol derivatives and fragrant Farnesol, and Neraniol were identified. In addition, muscone was identified as a minor component (1.3%) from the gland extraction. Present study indicates that the chemical ingredients between musk and nutria gland are quite different. Conclusively, using nutria gland as musk substitute in the medicine is not recommended. Part II. Study on the Synthesis of N-[(3-Alkylamino)-propyl] norglaucine A perusal of past studies of thaliporphine, an aporphine alkaloid, indicated positive inotropic and negative chronotropic effects as well as normalization of the arrhythmia induced by ouabain. Recently, Glaucine, an O-methylated derivative, was also demonstrated to be a potent anti-inflammatory agent. In order to increase the bioactivity of thaliporphine and glaucine, the dimmeric glaucine analogs were designed and prepared in this study. This study used laurolitsine, obtained from Phoebe formosana as raw material to prepare large quantity of norglaucine (6), a key intermediate for synthesizing thaliporphine and glaucine. Reaction of norglaucine with 1-bromo-3-chloropropane yielded N-(3-Chloropropyl) norglaucine (8). During the preparation of compound 8, we found a reaction condition to increase the yield of a common method from 20% to 75%. Treatment of compound 8 with various alkyl amine produced a series of N-[(3-Alkylamino)-propyl] norglaucine (9-13). The bioactivity of the prepared norglaucine derivatives remain to be assayed.
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YANG, YA-AN, et 楊雅安. « Part I、Synthesis of Coumarin-fused Pyrido[2,1-a]isoquinolin-8-ium Heterocycles and Their DerivativesPart II、Multicomponent Synthesis of (3E)-3-[Alkylamino(aryl)methylidene]chroman-2,4-diones and -Nitro Amide Derivatives ». Thesis, 2018. http://ndltd.ncl.edu.tw/handle/z6e558.
Texte intégralRésumé :
碩士東海大學
化學系
106
Part I、Synthesis of Coumarin-fused Pyrido[2,1-a]isoquinolin -8-ium Heterocycles and Their Derivatives Protoberberines are alkaloids that exhibit a wide range of biological activities such as antimicrobial, anti-inflammatory, antimalarial, and antitumor. Previous synthetic efforts have been primarily focused on the biological and therapeutic applications of protoberberines, their intrinsic photochemical properties were much less explored. In this study, a coumarin and pyrido[2,1-a]isoquinolin-8-ium-fused heterocycles were synthesized by p-TsOH-mediated coupling of 3-formylcoumarins and dihydroisoquinolines. The prepared compounds were further subjected to based-mediated ring opening and subsequent photochemical electrocyclization to investigate their potential functional properties. The synthetic details, structural characterization and photochemical properties of the prepared compounds were described. Part II、Multicomponent Synthesis of (3E)-3-[Alkylamino(aryl)methylidene]chroman-2,4-diones and -Nitro Amide Derivatives We have developed the nitromethane-mediated synthesis of (3E)-3-[alkylamino(aryl)methylidene]chroman-2,4-dione by one-pot three-component reaction and nitromethane-mediated synthesis of -nitro amide deriviates by one-pot four-component reaction in this thesis. Their molecular structures were characterized by 1H and 13C NMR spectra and X-ray crystal analysis. The mechanisms for the two reactions were proposed. Finally, the scope of the two multicomponent reactions were explored. Twenty four derivatives of (3E)-3-[alkylamino(aryl) methylidene]chroman-2,4-dione and three derivatives of -nitro amide were obtained.