Articles de revues : « Affiliate Program Selection »

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Yaremenko, Svitlana S., Iryna V. Taranenko, Valentyna M. Shevchenko et Mariia O. Kuzmenko. « INFLUENCE MARKETING AS AN EFFECTIVE TOOL FOR ATTRACTING CONSUMERS ». Європейський вектор економічного розвитку 2, n^o 35 (décembre 2023) : 125–42. http://dx.doi.org/10.32342/2074-5362-2023-2-35-10.

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The purpose of the article is to justify the importance of the company’s implementation of the partner program as an influencer marketing tool aimed at improving the company’s marketing communication system. The conducted analysis showed that the current state of companies’ marketing communications requires greater use of influencer marketing as an effective tool for influencing consumer purchase decisions, namely through the implementation of partnership programs that contribute to the formation of consumer trust in a specific brand, their retention and the creation of long-term relationships with them. On the basis of the conducted research devoted to the use of influencer marketing by the domestic drogerie chain “EVA”, the article justifies that the key to a successful and effective affiliate program is not only the organization of this process, but also the correct selection of bloggers. In the article a list of criteria that they must meet is represented. These criteria will help “EVA” to select bloggers for effective cooperation and positive influence on the brand. In the article 7 steps of implementation of the affiliate program for influencers from “EVA” are proposed. The introduction of an affiliate program will contribute an effective communication with bloggers and allow to create a base of influencers who can independently promote “EVA” without additional agreements. That is, it optimizes the working process for two company divisions: the marketing promotion of the Internet store “EVA”, and the influencer direction. In addition, the implementation of the program will allow to optimize the budget, since the funds will be planned as an investment in long-term partnership relations that are beneficial to both parties. This will help to provide continuous exposure for “EVA” and its online store, so the company will get more exposure to the audience for a relatively small cost. Using a specific example in the article, it is justified that the company can afford to implement a partner program not just as an ordinary one with commissions, but as affiliate program in the format of building a bloggers community. When implementing the program, the involved bloggers will be the face of the brand as well as additional marketing channel of communication through which “EVA” new marketing communications can be transmitted. Moreover, since influencers will be brand representatives, they will also build the positioning of the company for the audience, contribute the increase of loyalty, which will positively affect the further development of the company. In further research, it will be appropriate to consider the effectiveness of the implementation of partner programs and the spread of their use in other industries.

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Anella, Louis B., Michael A. Schnelle et Dale M. Maronek. « Oklahoma Proven—A Statewide Marketing and Evaluation Program ». HortScience 35, n^o 4 (juillet 2000) : 555B—555a. http://dx.doi.org/10.21273/hortsci.35.4.555b.

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Oklahoma Proven (OKP) is a plant promotion and evaluation program designed to help consumers choose plants appropriate for Oklahoma gardens. Aiding consumers with plant selection will lead to greater gardening success, enthusiasm, and increased sales for Oklahoma green industries. There are two major facets to the program: marketing, coordinated by Dr. Lou Anella, and evaluation, coordinated by Dr. Michael Schnelle. Plants to be promoted by OKP will be selected by an OKP executive committee based on recommendations from an OKP advisory committee comprised of industry professionals, cooperative extension specialists and educators, Oklahoma Botanical Garden and Arboretum affiliate members, and Department of Horticulture and Landscape Architecture faculty. Plants chosen for OKP must meet the following selection criteria: appropriate for gardens throughout the state of Oklahoma; readily available in the trade; limited input required, i.e. few pest or disease problems, tolerant of Oklahoma's diverse soil types and weather conditions; noninvasive; can be profitably produced. The OKP Advisory Board selected the following OKP Selections for 2000: Taxodium distichum; Spiraea japonica `Magic Carpet'; Verbena canadensis `Homestead Purple'; and Scaevola aemula. Promotional materials, such as posters and signs, will be available just after the first of the year, and the promotional push will begin in early March. Posters and signs will be distributed to retailers throughout the state free-of-charge and pot stakes and hang tags will be sold to wholesalers as a means of generating income for the Oklahoma Proven program. OKP plants will also be promoted through the television show “Oklahoma Gardening,” extension newsletters, and the press.

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Fox, Paul B., et Jonathan D. Wareham. « Governance Mechanisms in Internet-Based Affiliate Marketing Programs in Spain ». International Journal of E-Business Research 6, n^o 1 (janvier 2010) : 1–18. http://dx.doi.org/10.4018/jebr.2010100901.

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Internet-based affiliate marketing programs have emerged as one of the fastest-growing methods for online retailers to acquire customers and increase sales by tapping into the power of independent web sites to reach a large, diverse audience of potential customers. However, while these programs have proven effective in increasing website traffic and sales, illegal or inappropriate activities on the part of affiliates could negatively impact a retailer’s brand in the eyes of customers. This study is an exploratory analysis of governance mechanisms (formal contracts, partner selection, incentives and monitoring) in one-to-many affiliate programs in Spain. Agency theory and transaction cost analysis provide the theoretical background. The conclusion is that there is a significant lack of transparency in the guidance and restrictions communicated to affiliates, and a lack of systematic monitoring of affiliate behavior, which increases the risk of opportunism or misconduct. General recommendations for managers of affiliate programs are considered.

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Mosha, Donnati M. S. « Preface ». Pure and Applied Chemistry 77, n^o 11 (1 janvier 2005) : vi. http://dx.doi.org/10.1351/pac20057711vi.

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The 9th International Chemistry Conference in Africa (ICCA-9), Africa's continent-wide premier conferencing event in the chemical sciences, was this year hosted in Tanzania. Organized under the umbrella of the continent's African Association of Pure and Applied Chemistry (AAPAC), the event takes place every third year on a rotating basis, in a country so designated at the preceding meeting, with the national affiliate as hosts. This year's event was held for the first time since AAPAC instituted the series in 1990, in the scenic tourist setting of Arusha in northern Tanzania from 2-7 August 2004. That event, hailed as among the continent's most successful, was by coincidence, befittingly held at this panoramic location which has been designated as the exact Cape-to-Cairo midpoint and has as its backdrop, Mt. Kilimanjaro, the highest point on the continent. The event brought together participants from over 60 countries from the five continents, and the scientific sessions included a total of over 100 lectures, presentations, and posters. The social program was structured to afford participants the opportunity to sample nature's unique and spectacular wildlife heritage in the proximity, including the world famous game parks of the Serengeti and the Ngorongoro Crater, which have no parallel elsewhere.The scientific coverage included topics in analytical, physical, organic, environmental, industrial, and natural products chemistry. Delegates heard from the International Union of Pure and Applied Chemistry (IUPAC), who sponsored the event; the Royal Society of Chemistry, from whom generous conferencing input was sourced; and the American Chemical Society, who sent representatives to grace the event; plus the local partners of the Tanzania Chemical Society (TCS), the national affiliate to IUPAC and AAPAC. The official theme of the conference, "Chemistry towards disease and poverty eradication", was more than adequately targeted by the scientific conference content, which did it justice by exploring, evaluating, and demonstrating how advances in the chemical sciences and technology form vital partnerships toward those goals across the continent. This issue of Pure and Applied Chemistry features a small selection of papers arising from the main lecture program, and serves to exemplify important features of the conference theme.After a general assembly to elect new AAPAC office bearers for the coming triennium, the conference wound up business amidst unprecedented optimism that the road to success is always under construction, and that through this gathering we had cast off doubt, demonstrating and providing solid evidence that this activity is alive and well in all corners of the continent. With that upbeat note, delegates bade farewell to each other and to Arusha 2004, promising to gather again in three years time in Botswana for the 10th International Chemistry Conference in Africa.Donnati M. S. MoshaConference Editor

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Curtis, Sarah, Heather Martin, Michelle DiNella, Barry Lavallee, Caroline Chartrand, Lorraine McLeod, Cathy Woods et al. « Kidney Check Point-of-Care Testing—Furthering Patient Engagement and Patient-Centered Care in Canada’s Rural and Remote Indigenous Communities : Program Report ». Canadian Journal of Kidney Health and Disease 8 (janvier 2021) : 205435812110037. http://dx.doi.org/10.1177/20543581211003744.

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Purpose of program: Access to health care services remains a significant barrier for many Indigenous people’s living in rural and remote regions of Canada. Driven by geographical isolation and compounded by socioeconomic and environmental disparities, individuals living under these circumstances face disproportionately poor health outcomes. Kidney Check is a comprehensive screening, triage, and treatment initiative working to bring culturally safe preventive care to rural and remote Indigenous communities across Manitoba, Ontario, BC, Alberta, and Saskatchewan. The project’s patient-oriented approach addresses concerns raised by kidney patients and their caregivers using culturally safe practices. Using the various expertise of their multidisciplinary team, Kidney Check seeks to further collaborative efforts to improve access to preventive health care for these groups. Meaningful engagement with patients, communities, and local health care stakeholders ensures Indigenous voices are heard and incorporated into the project in a way that promotes shared decision-making and sustainability. Sources of information: As an affiliate program of the Can-SOLVE CKD Network, Kidney Check’s guiding priorities were developed over 3 years of patient consultation and finalized during 2 workshops held with more than 30 patients, caregivers, Indigenous peoples, researchers, and policy makers using a modified Delphi process. Today, patients continue to participate in project development via 2 governing bodies: The Patient Governance Circle and the Indigenous Peoples Engagement and Research Council (IPERC). Methods: Modeled after the Indigenous-led 2015 FINISHED project in Manitoba, Kidney Check employs point-of-care testing to identify diabetes, hypertension, and chronic kidney disease (CKD) in individuals, ages 10 and above, regardless of pre-existing risk factors. The Kidney Check team consists of 4 working groups: project leadership, provincial management, local community partners, and patient partners. By using and building on existing relationships between local and provincial health care stakeholders and various Indigenous communities, the program furthers collaborative efforts to bridge gaps in health equity. Key findings: The Kidney Check program has established an infrastructure that integrates patient engagement at all stages of the program from priority setting to deployment and dissemination strategies. Limitations: While we encourage and offer screening services to all, many still choose not to attend for a variety of reasons which may introduce selection bias. Kidney Check uses patient engagement as a foundational component of the program; however, there is currently a limited amount of research documenting the benefits of patient engagement in health care settings. More formal qualitative evaluations of these activities are needed. In addition, as the COVID-19 pandemic has halted screening procedures in most communities, we currently do not have quantitative data to support the efficacy of the Kidney Check program. Implications: For many Indigenous people, lack of accessibility to health care services is compounded by sociopolitical barriers that disrupt relationships between patients and providers. Meaningful engagement presents one opportunity to ensure the voices and perspectives of Indigenous patients and communities are incorporated into health services. In addition, this screening paradigm has shown to be cost effective as shown by analyses done on the FINISHED screening program.

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Shaath, Deena S., et Thomas J. Whittaker. « Evaluation of Ophthalmology Residency Program Web Sites ». Journal of Academic Ophthalmology 11, n^o 02 (juillet 2019) : e44-e48. http://dx.doi.org/10.1055/s-0039-3400736.

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Abstract Objective This article evaluates the current availability of information on residency program Web sites that may be of interest to residency applicants. Design Cross-sectional analysis of 117 Accreditation Council for Graduate Medical Education (ACGME)-accredited ophthalmology residency program Web sites from October 17, 2018 to December 17, 2018. Methods Programs were identified through the ACGME-specialty search, and the URL links provided by the program were evaluated for directing the user to the institution, department, or residency program. If a link was not functional or not provided, programs were identified through a Google search. Web sites were evaluated for having information on how to apply, application requirements and eligibility, and providing a link to the San Francisco (SF) Match. Educational content included: didactic instruction, rotation overview, research requirement information, active and/or past research, institutional conferences, academic conferences, call schedules, and charitable work. Recruitment content included current residents and faculty and their biographies, graduate placement, salary, benefits, surrounding area information, message from the Program Director, Chair, and/or Chief Residents, surgical statistics, affiliated hospital information, selection criteria, and association links. Data was stratified by program size, geographic region, and top 20 hospitals in ophthalmology by the U.S. News & World Report. Results Nonfunctional links were provided by 16.2% of programs, and 3.4% did not provide a link. Application instructions were presented by 83% of programs and 77% provided a link to the SF Match. Greater than 80% provided didactic instruction, rotation overviews, research expectations of residents, and faculty and resident listings. Up to half of programs listed information about application requirements and eligibility, call schedules, surgical statistics, academic conferences, charitable work, salary, and selection criteria. A message to applicants was displayed by 48% of programs, and 16% of programs provided association links. Programs with more than 15 residents provided more educational content than programs with less than 12 (p = 0.042). Differences in recruitment content were observed among programs in the Northeast and West, (p = 0.003) and programs in the South and West (p = 0.037). No other differences were observed. Conclusion The Internet is frequently consulted during the residency application process. Many programs provide basic information, but this can be further optimized to maximize the utility of residency Web sites.

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Anella, Louis B., Michael A. Schnelle et Dale M. Maronek. « Oklahoma Proven : A Plant Evaluation and Marketing Program ». HortTechnology 11, n^o 3 (janvier 2001) : 381–84. http://dx.doi.org/10.21273/horttech.11.3.381.

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Oklahoma Proven is a plant evaluation and marketing program developed by the Department of Horticulture and Landscape Architecture at Oklahoma State University. An advisory committee comprised of representatives from state agencies, industry, and Oklahoma Botanical Garden and Arboretum Affiliate Gardens makes plant recommendations to an executive committee which in turn selects one tree, shrub, perennial, and annual for promotion each year. Trees and shrubs are selected 3 to 5 years ahead of promotion while perennials and annuals are selected 1 to 2 years in advance to give nurseries time to increase production. Marketing includes posters, billboards, pot stakes, and hang tags with the Oklahoma Proven logo and related extension service programming and news coverage. Consumers appreciate having help selecting plants and one retail nursery reported an 81% increase in sales of Oklahoma Proven plants. Funding for the program is provided by industry, Oklahoma Agricultural Experiment Station, Oklahoma Cooperative Extension Service, and a grant from Oklahoma Department of Agriculture.

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Khalil, Amanda J., Krutika N. Mediwala, Meera Mehta, Amy J. Yanicak, Jared S. Ham, Elizabeth W. Blake, Kathey F. Rumley, Ingrid Pan et P. Brandon Bookstaver. « Survey of residency program directors’ perceptions of nontraditional pharmacy residency applicants ». American Journal of Health-System Pharmacy 76, n^o 21 (15 octobre 2019) : 1788–93. http://dx.doi.org/10.1093/ajhp/zxz191.

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Abstract Purpose The attitudes and expectations of residency program directors (RPDs) regarding nontraditional residency applicants (NTAs) were evaluated. Methods This was a cross-sectional, survey-based study targeting RPDs of American Society of Health-System Pharmacists–accredited residency programs. A 14-question survey requesting information related to demographics, perceptions of NTAs compared with traditional applicants, advantages and disadvantages of NTAs, and advice for NTAs was administered electronically to RPDs. The primary outcome of this study was to determine RPDs’ perceptions of NTAs as suitable residency candidates. The secondary outcome evaluated the rate of NTA acceptance into residency programs and a qualitative assessment of RPDs’ advice for NTAs. Results Of the 1,414 RPDs contacted to participate, 328 (23%) completed the survey. RPDs were primarily affiliated with postgraduate year 1 pharmacy practice (52%) or postgraduate year 2 specialty residencies (30%), and 35% reported having an NTA in their program. Most respondents (87%) reported that NTAs are given equal consideration relative to traditional residency applicants. RPDs rated work experience as the most important quality of an NTA, followed closely by the ability to work with others and teachability. Most (277 [85%]) RPDs agreed that NTAs should possess experiences beyond work experience, such as research, leadership, and community service. The biggest concern regarding NTAs was significant time since graduation prior to application. Conclusion The majority of RPDs did not perceive NTAs differently from traditional applicants in the selection process of prospective candidates.

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Patel, Hares, Ram Yakkanti, Krishna Bellam, Kofi Agyeman et Amiethab Aiyer. « Innovation in Resident Selection : Life Without Step 1 ». Journal of Medical Education and Curricular Development 9 (janvier 2022) : 238212052210849. http://dx.doi.org/10.1177/23821205221084936.

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INTRODUCTION The announcement of Step 1 shifting to a Pass/Fail metric has prompted resident selection committees (RSCs) to pursue objective methods of evaluating prospective residents. Regardless of the program's specialty or affiliated hospital/school, RSCs universally aim to recognize and choose applicants who are an “optimal fit” to their programs.1 An optimal fit can be defined as a candidate who thrives in the clinical and academic setting, both contributing to and benefiting from their respective training environments. OBJECTIVE The objective of this scoping review is to evaluate alternative, innovative methods by which RSCs can evaluate applicants and predict success during residency. Objective methods include: Step 2 scores, Traditionally Used Metrics (core clerkship scores), interview performance, musical talent, sports involvement, AOA membership, research publications, unprofessional behavior, Dean's letters, Rank list, judgement testing, and specialty-specific shelf exams.13–15 METHODS A scoping review was performed in compliance with the guidelines indicated by the PRISMA Protocol for scoping review.18 9308 results were identified in the original PubMed search for articles with the key words “Resident Success”. Abstract screening and application of inclusion and exclusion criteria yielded 97 articles that were critically appraised via review of full manuscript. RESULTS Of the articles that focused on personality traits, situational judgement testing, and specialty specific pre-assessment, all of them demonstrated some level of predictability for resident success. Standardized Letter of Recommendations, Traditionally Used Metrics, and STEP 2 did not show a unanimous consensus in demonstrating predictability of a resident's success, this is because some articles suggested predictability and some articles disputed predictability. CONCLUSION The authors found personality traits, situational judgement testing, and specialty specific assessments to be predictive in selecting successful residents. Further research should aim to analyze exactly how RSCs utilize these assessment tools to aid in screening their large and competitive applicant pools to find residents that will be successful in their program.

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Harber, B. W., et SA Miller. « Program Management and Health Care Informatics : Defining Relationships ». Healthcare Management Forum 7, n^o 4 (décembre 1994) : 28–35. http://dx.doi.org/10.1016/s0840-4704(10)61075-7.

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The program management (PM) structure is a relatively well-known organizational model for hospitals. A variation of the matrix structure, it allows for an interdisciplinary team of health care providers to facilitate patient care delivery. However, providing such focused care results in a complex, highly information-dependent operational environment. To meet the information needs of such an environment, careful planning in selecting and implementing technology is required. Along with supporting patient care, the technology will also help in managing costs, human resources, quality and utilization, as well as in monitoring performance and outcomes measurement. Focusing specifically on the information technology environment, this article addresses health care in formatics (the diverse categories of information and systems) needed to support clinical program managers, executives and others in a PM organization. Examples from both a university-affiliated and a community-based program managed hospital illustrate their approach to PM and information technology.

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Eggleston, Alyson, et Jessica Petrie. « 165 Predicting Success : A Mixed Model of KL2 Trainee Profiles and Outcomes ». Journal of Clinical and Translational Science 8, s1 (avril 2024) : 49–50. http://dx.doi.org/10.1017/cts.2024.158.

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OBJECTIVES/GOALS: Penn State CTSI supports KL2 career development awards for faculty seeking to become leaders in clinical and translational research. CTSAs can benefit from a better understanding of KL2 applicant profiles and trainee outcomes. Predictive modeling of KL2 records provides insights into institutional processes and continuous improvement goals. METHODS/STUDY POPULATION: Collecting KL2 application records at Penn State CTSI from 2017 to 2023, comprising both accepted and not accepted candidate profiles, this study used a generalized logistic mixed model with binomial distribution to understand the factors predictive of KL2 trainee acceptance, (n=47). The following factors were modeled as potentially predictive of scholars’ acceptance: Institution-specific Processes—Campus; Terminal Degree Type; College of Residency, Applicant Demographics and Portfolio—Minoritized or Protected Groups; Mean Application Score; Rurality Focus; Gender, and Outcomes—Post-Program h-index. RESULTS/ANTICIPATED RESULTS: Only Campus and Degree were significant factors predictive of trainee acceptance (r<.0001), with a particular campus and the MD degree-designation both exerting selectional pressures on acceptance rates. Applicant demographics were not significant historical factors in selection despite the most recent trainee cohort comprised of all women. Similarly, while our CTSA focuses on rural inequality and accessibility, a research proposal focused on rurality was not a significant factor for acceptance. Notably, NIH-scaled application scores and post-program h-indices were not significant for accepted and non-accepted applicants. DISCUSSION/SIGNIFICANCE: The absence of applicant-focused selectional pressure is striking—Penn State CTSI does not significantly select for gender, URM, or URP status. Administration is now empowered to intentionally engage, recruit, and retain from our other affiliated campuses and colleges.

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Karki, Tek Mani. « A Study of Practical Examinations : Provision and Practices ». Tribhuvan University Journal 35, n^o 1 (30 juin 2020) : 97–110. http://dx.doi.org/10.3126/tuj.v35i1.35874.

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Tribhuvan University, Faculty of Education has introduced four-year annual B. Ed. program in 2015. The Department of English Education has of fereda course with theory plus practice in nature each year in this program. One of the courses with this nature is ‘Research Methodology in English Education’, introduced in the fourth year. Concerning the practical portion of this course, this paper highlights the variations of research reports and explores the challenges faced by the subject teachers (internal examiners) and the students selecting five affiliated campuses applying convenient sampling procedure in Bagmati province. Five research reports (one from each campus) selected randomly were analyzed, five teachers and five students (one from each campus) purposively selected were interviewed to gather information, and the data were interpreted thematically. Considerable amount of variation appeared in the research reports in terms of format, content, and citations and referencing style. Challenges occurred when the teachers did not receive clear guidelines from the concerned authorities to uniform the practical works. Students’ irregularities seemed another challenge for quality improvement in research works. The challenges can be minimized by implementing the course guidelines in practice. For this, the concerned authorities can organize several programs to support the teachers and to attract the students attending the classes regularly at the campuses.

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Das, Rosalina, Eva Olivares, Sheela Dominguez et Erin Kobetz. « 422 Addressing complex and urgent problems through innovative team science : The University of Miami Laboratory for Integrative Knowledge (U-LINK) ». Journal of Clinical and Translational Science 7, s1 (avril 2023) : 126. http://dx.doi.org/10.1017/cts.2023.455.

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OBJECTIVES/GOALS: The goal of U-LINK is to bring together diverse scholars from multiple disciplines to address complex and challenging problems in healthcare, climate change, social equity, and community, through innovative team science, and aligned with the University of Miami’s strategic plans. METHODS/STUDY POPULATION: The U-LINK program has supported developmental and implementation projects through a competitive selection process. Developmental funding was intended for teams to develop and refine ideas and to become established as an effective team. Additional funding was provided to teams to advance their projects by conducting data collection and feasibility testing. In addition, U-LINK has supported fellowship for pre-doctoral and affiliated doctoral trainees. Team science training was provided to all teams through didactic lectures and hands-on training. Teams were tracked longitudinally by using surveys and bibliometrics to measure success and impact including scholarly output and follow on funding. Network analysis was performed to analyze research collaboration networks before and after ULINK funding. RESULTS/ANTICIPATED RESULTS: U-LINK has funded pilot programs and initial phases for 57 projects and 13 fellowships in the last three years. Over 400 individuals on teams from 16 schools/academic units collaborated on these projects on topics such as resilience, climate change, social equity and societal challenges, health, and impact of recent legislation on LGBTQ+ community. While data collection and analysis are ongoing, initial results show successful outcomes from U-LINK projects including publications and $29.5m in follow-on external funding. We anticipate network analysis to demonstrate increased and continued multi-disciplinary collaborations among U-LINK teams through co-authorship networks and increase in collaborative grants being submitted and/or funded. DISCUSSION/SIGNIFICANCE: The University of Miami’s U-LINK program has demonstrated success in forming interdisciplinary teams that have produced real-world solutions to complex problems by harnessing the inherent diversity and strength across UM’s programs.

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El-Zubair, Banaga Taha, El-Rusheed Habob Mohammed et Huda Salem Alkubaisi. « Teacher Education, Teacher Preparation and Professional Development of Secondary Schoolteachers in Light of Recent Global Trends ». Journal of Education and Training Studies 7, n^o 11 (9 septembre 2019) : 91. http://dx.doi.org/10.11114/jets.v7i11.4434.

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The purpose of this study is to present a brief overview of the nature of teacher education and preparation programs, and the professional development of secondary schoolteachers in the Arab world, and to offer insights into recent global trends in the matter.By examining some of the relevant literature and scholarly work, this study’s main objective is to provide a comprehensive picture of the teacher-program-related policies offered by education colleges/institutions in the region in the light of global trends. To achieve this, the researchers surveyed most of the existing related studies conducted in the region. This was pursued through analysis of evidence, methodologies, underlying ideologies, and indicators of examined literature. Similarly, an analysis of publications relating to recent global trends was undertaken.Results suggest that a comprehensive “five-year” teacher programs is ideal to be integrated into higher education in the Arab world due to its feasibility, affordability as well as lower financial costs. It was found that that the components of existing teacher programs must be subject to evaluation and review for further development. However, the results indicate not only that the strategy of candidate admission and enrollment in colleges are not based on appropriate criteria, but also that a clear policy for teaching licensure is ignored.The study emphasizes the need to establish fully equipped teacher training centers. To attain this, we strongly suggest selecting or creating well-equipped and administratively affiliated schools to the colleges to provide an experimental environment for candidates to practice what they have learned. Achieving a balance between different course packages should be considered.

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Özen, Fatmanur, et Müzeyyen Altunbay. « Students' Expectations From Postgraduate Education and the Factors Affecting Course and Advisor Selection Processes : The Case of a City University ». Yuksekogretim Dergisi 11, n^o 1 (29 avril 2021) : 97–110. http://dx.doi.org/10.2399/yod.20.722456.

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Postgraduate education consisting of master's, doctorate and proficiency in arts programs is an educational process that continues according to certain criteria after undergraduate education. It is the education process through which certain specializations and doctorate qualifications are gained. In this quantitative study, the expectations of graduate students studying at Giresun University, which has a city university status in Turkey, from postgraduate education, i.e. their reasons for continuing with their postgraduate education and the factors affecting their selection of courses and advisors are investigated. With the help of a questionnaire created by the researchers in line with the opinions of the field experts, the data were collected from a group of graduate students who were attending the programs affiliated with Giresun University Graduate School of Science and Social Sciences. The results obtained from the data analyzed by using descriptive statistics, conceptual connotation and descriptive analysis show that the main expectation of the participants is to pursue an academic career. Thus, postgraduate education evokes 'academia' and 'development' the most. They are careful to choose the courses related to the field they will study and research and they mostly learn about the content of the courses by reading the course contents published electronically. In the selection of advisors, while some of the postgraduate students chose their advisor according to their academic discipline; the majority was automatically assigned an advisor without first asking for their opinions. In the two graduate schools where the research is conducted the course and advisor selection processes should be improved and the quality of the offered programs should be increased by aligning them with the student expectations from postgraduate education.

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San Martin, Maria T., Ruth Rios, Barbara Segarra, Karen G. Martinez, Estela Estape et Margarita Irizarry-Ramírez. « 2531 Phase II award : Evaluation of outcomes in preparing independent researchers by continued mentoring and career development support (2006–2016) ». Journal of Clinical and Translational Science 2, S1 (juin 2018) : 59. http://dx.doi.org/10.1017/cts.2018.221.

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OBJECTIVES/SPECIFIC AIMS: The Hispanic Clinical and Translational Education and Career Development program entails formal research training (Phase I) through an established post-doctoral Master of Science in Clinical and Translational Research. The most qualified graduates from Phase I compete to receive 1–2 years support for continued mentoring and career development (Phase II program) aiming to apply for a regular research grant or career award (K or R series). OBJECTIVE: This project aims to present an evaluation of the Phase II program and Scholars outcomes. METHODS/STUDY POPULATION: METHODS: Participants (n=12) responded to a semistructured interview including 43 questions about program’s processes and outcomes. Descriptive and content analysis was done. RESULTS/ANTICIPATED RESULTS: RESULTS: Results show that 83% are women, 42% are MD, and 67% are affiliated to the University of Puerto Rico-Medical Sciences Campus and 67% were able to fulfill their career development expectations during the Phase II Award. At present (92%) are conducting clinical research in their current position. Outcomes include new selection of research line, K Awards, and enhanced skills in clinical and translational research DISCUSSION/SIGNIFICANCE OF IMPACT: DISCUSSION: Challenges identified were: time management, better coaching and a more structured mentoring experience. The main benefit of the program were protected time, research budget, and the opportunity to acquire more research experience.

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Lu, Qin-Pei, Yong-Mei Huang, Shao-Wei Liu, Gang Wu, Qin Yang, Li-Fang Liu, Hai-Tao Zhang et al. « Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula ». Marine Drugs 19, n^o 12 (1 décembre 2021) : 688. http://dx.doi.org/10.3390/md19120688.

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Mangrove actinomycetia are considered one of the promising sources for discovering novel biologically active compounds. Traditional bioactivity- and/or taxonomy-based methods are inefficient and usually result in the re-discovery of known metabolites. Thus, improving selection efficiency among strain candidates is of interest especially in the early stage of the antibiotic discovery program. In this study, an integrated strategy of combining phylogenetic data and bioactivity tests with a metabolomics-based dereplication approach was applied to fast track the selection process. A total of 521 actinomycetial strains affiliated to 40 genera in 23 families were isolated from 13 different mangrove soil samples by the culture-dependent method. A total of 179 strains affiliated to 40 different genera with a unique colony morphology were selected to evaluate antibacterial activity against 12 indicator bacteria. Of the 179 tested isolates, 47 showed activities against at least one of the tested pathogens. Analysis of 23 out of 47 active isolates using UPLC-HRMS-PCA revealed six outliers. Further analysis using the OPLS-DA model identified five compounds from two outliers contributing to the bioactivity against drug-sensitive A. baumannii. Molecular networking was used to determine the relationship of significant metabolites in six outliers and to find their potentially new congeners. Finally, two Streptomyces strains (M22, H37) producing potentially new compounds were rapidly prioritized on the basis of their distinct chemistry profiles, dereplication results, and antibacterial activities, as well as taxonomical information. Two new trioxacarcins with keto-reduced trioxacarcinose B, gutingimycin B (16) and trioxacarcin G (20), together with known gutingimycin (12), were isolated from the scale-up fermentation broth of Streptomyces sp. M22. Our study demonstrated that metabolomics tools could greatly assist classic antibiotic discovery methods in strain prioritization to improve efficiency in discovering novel antibiotics from those highly productive and rich diversity ecosystems.

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Alvarado-Ramy, Francisco, Elise M. Beltrami, Louise J. Short, Pamela U. Srivastava, Keith Henry, Meryl Mendelson, Julie L. Gerberding et al. « A Comprehensive Approach to Percutaneous Injury Prevention During Phlebotomy : Results of a Multicenter Study, 1993-1995 ». Infection Control & ; Hospital Epidemiology 24, n^o 2 (février 2003) : 97–104. http://dx.doi.org/10.1017/s019594170008509x.

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AbstractObjective:To examine a comprehensive approach for preventing percutaneous injuries associated with phlebotomy procedures.Design and Setting:From 1993 through 1995, personnel at 10 university-affiliated hospitals enhanced surveillance and assessed underreporting of percutaneous injuries; selected, implemented, and evaluated the efficacy of phlebotomy devices with safety features (ie, engineered sharps injury prevention devices [ESIPDs]); and assessed healthcare worker satisfaction with ESIPDs. Investigators also evaluated the preventability of a subset of percutaneous injuries and conducted an audit of sharps disposal containers to quantify activation rates for devices with safety features.Results:The three selected phlebotomy devices with safety features reduced percutaneous injury rates compared with conventional devices. Activation rates varied according to ease of use, healthcare worker preference for ESIPDs, perceived “patient adverse events,” and device-specific training.Conclusions:Device-specific features and healthcare worker training and involvement in the selection of ESIPDs affect the activation rates for ESIPDs and therefore their efficacy. The implementation of ESIPDs is a useful measure in a comprehensive program to reduce percutaneous injuries associated with phlebotomy procedures.

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Brubaker, Lauren, Katy Schroeder, Dawn Sherwood, Daniel Stroud et Monique A. R. Udell. « Horse Behavior towards Familiar and Unfamiliar Humans : Implications for Equine-Assisted Services ». Animals 11, n^o 8 (11 août 2021) : 2369. http://dx.doi.org/10.3390/ani11082369.

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While human benefits of animal-assisted therapy programs have been documented, relatively little research has been conducted on behavioral factors that predict a successful equine-assisted services (EAS) horse. This study compares the behavior of experienced and non-experienced EAS horses as well as horses selected for future EAS work in a series of sociability and temperament tests. No significant differences were found between experienced and non-experienced horses in the sociability measures or for most of the temperament tests; however, significant differences were found between groups in the brushing test, with non-experienced horses showing more affiliative behaviors towards the familiar handler and unfamiliar persons. No significant differences were found between selected and non-selected horses in the temperament tests. However, non-selected horses were found to show significantly more affiliative behaviors towards a familiar person during a sociability test compared with selected horses. These findings suggest that the social behavior and temperament of EAS horses may not be significantly different from other available horses not selected for EAS work. Instead, these decisions may primarily reflect subjective impressions of fit. Interestingly, on measures where significant differences were identified, the horses not actively engaged in or selected for therapy were the ones that showed greater affiliative responses to familiar and unfamiliar humans. Reasons for why this may be, as well as future directions in EAS selection, are discussed.

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Jamalnik, Maryam, Mohammad Reza Falsafinejad et Anahita Khodabakhshi-Koolaee. « Long-term Marital Satisfaction : Couples’ Narratives of the Role of Mate Selection ». Journal of Client-centered Nursing Care 6, n^o 4 (1 novembre 2020) : 267–76. http://dx.doi.org/10.32598/jccnc.6.4.337.1.

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Background: Long-term marital satisfaction depends on various factors in couples’ lives. Shared interests, beliefs, and goals can guarantee couples’ long and satisfying relationships. However, mate selection is one of the primary requirements for establishing a marital relationship in both modern and traditional societies. Based on the narratives of couples, the present study aimed to explore the role of mate selection in marital satisfaction. Methods: This study employed a qualitative narrative research design. The participants were couples who lived together at least for 10 years, were satisfied with their married life, and had children. They were selected through the purposive sampling method from the family entertainment centers of health houses affiliated with Qom Municipality, in 2019. The data were generated using in-depth in-person interviews. After interviewing 13 couples, theoretical saturation was obtained. The data were recorded, transcribed, and analyzed manually using the textual analytic approach. Results: The analysis of the participants’ narratives showed that the couples believed that four main themes, including spouse personality traits, shared religious beliefs, shared socioeconomic positions, and mutual respect and understanding affected their marital satisfaction. Conclusion: The couples who were satisfied with their marriage believed that realistic and correct mate selection played a vital role in the survival and stability of their marital life. It is very important to pay attention to the role and conditions of mate selection and its impact on the stability of marriage. Results from this study help counselors, couples’ therapists, mental health professionals, psychiatric nurses, and midwifery consultants prepare couples for premarital programs.

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Ebert, Steven C. « 1049. Using Alternative Alerts in the Electronic Health Record to Guide Antimicrobial Selection Decisionmaking at the Point of Order Entry ». Open Forum Infectious Diseases 6, Supplement_2 (octobre 2019) : S370. http://dx.doi.org/10.1093/ofid/ofz360.913.

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Abstract Background In a White Paper published in 2019, SHEA describes “The role of electronic health record and ‘add-on’ clinical decision support systems to enhance antimicrobial stewardship programs.” Modifications of the electronic health record and add-on clinical decision support systems are compared and contrasted. Some disadvantages of modification of the EHR include the need to include all end-user affiliates in modifications, lack of order set utilization, and heavy demands of IT staff to modify the EHR. We have utilized alternative alerts which may be customized to individual affiliates and are relatively easy to build which fire when specific medications are ordered (whether within order sets or not) and guide clinicians to more appropriate antibiotic choices. Methods From an antimicrobial stewardship perspective, alternative alerts are activated during the ordering of antibiotics for which routine use is discouraged (e.g., carbapenems, fluoroquinolones). When a provider enters an order, the alternative alert will pop up. The alert consists of two sections: an alert section describing the reason for the alert and a list of therapeutic options for the targeted drug; and links to orders for alternative antibiotics/combinations. The alerts may be configured to allow or not allow the orderer to continue with the original order. Different alternative alerts can be created and used at different facilities using the same EHR platform. We designed alternative alerts for fluoroquinolones, carbapenems, and fifth-generation cephalosporins that allowed providers to continue with the original order. We tested their impact on antimicrobial prescribing for 18 months after implementation, measured as quarterly days of therapy (DOT)/1000 pt-days. Results We noted marked reductions in quarterly DOT/1000 pt-days for fluoroquinolones (-70%) and fifth-generation cephalosporins (-90%). The impact on carbapenem prescribing was more variable. Conclusion Alternative alerts represent an easily created, customizable means to guide providers’ antimicrobial selections. We plan to incorporate more alternative alerts into our antimicrobial ordering process and strengthen the alert for carbapenems. Disclosures All authors: No reported disclosures.

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Medina, Cesar A., Harpreet Kaur, Ian Ray et Long-Xi Yu. « Strategies to Increase Prediction Accuracy in Genomic Selection of Complex Traits in Alfalfa (Medicago sativa L.) ». Cells 10, n^o 12 (30 novembre 2021) : 3372. http://dx.doi.org/10.3390/cells10123372.

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Agronomic traits such as biomass yield and abiotic stress tolerance are genetically complex and challenging to improve through conventional breeding approaches. Genomic selection (GS) is an alternative approach in which genome-wide markers are used to determine the genomic estimated breeding value (GEBV) of individuals in a population. In alfalfa (Medicago sativa L.), previous results indicated that low to moderate prediction accuracy values (<70%) were obtained in complex traits, such as yield and abiotic stress resistance. There is a need to increase the prediction value in order to employ GS in breeding programs. In this paper we reviewed different statistic models and their applications in polyploid crops, such as alfalfa and potato. Specifically, we used empirical data affiliated with alfalfa yield under salt stress to investigate approaches that use DNA marker importance values derived from machine learning models, and genome-wide association studies (GWAS) of marker-trait association scores based on different GWASpoly models, in weighted GBLUP analyses. This approach increased prediction accuracies from 50% to more than 80% for alfalfa yield under salt stress. Finally, we expended the weighted GBLUP approach to potato and analyzed 13 phenotypic traits and obtained similar results. This is the first report on alfalfa to use variable importance and GWAS-assisted approaches to increase the prediction accuracy of GS, thus helping to select superior alfalfa lines based on their GEBVs.

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Roy, Arya Mariam, Ziad Bakouny, Nazli Dizman, Zeynep Irem Ozay, Bhavesh Mohan Lal, Rashad Nawfal, Marc Eid et al. « International medical graduates (IMG) representation at international oncology conference meetings. » Journal of Clinical Oncology 42, n^o 16_suppl (1 juin 2024) : 9000. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.9000.

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9000 Background: Despite IMGs accounting for up to one-third of all practicing oncologists in the United States, little is known about their contributions to presentations at international oncology meetings, such as the American Society of Clinical Oncology (ASCO). Therefore, we investigated the representation of IMGs in invited faculty roles at ASCO Annual Meetings. Methods: Speaker presentation details at ASCO 2022 and 2023 Annual Meetings were collected using publicly available program guides. We collected presentation-level variables of invited faculty roles (discussant, moderator, chairmanship, session topic presenter) and original research type (oral abstract, poster discussion, plenary session). Speaker-level variables comprised presumed gender, academic rank, and institution. Speakers were categorized into the following groups - American Medical Graduate (AMG): currently affiliated with a US institution, completed medical school in the US; IMG: affiliated with a US institution, completed medical school outside the US; non-US based speakers: affiliated with an institution outside the US; non-MD speakers. Univariable and multivariable analyses were employed to assess factors associated with the selection of presenters for invited faculty roles. Results: A total of 3337 presentations (1649 from 2022, 1688 from 2023) were included. 71.6% of the speakers were US-based, 56.6% were male and 40.5% were full professors. The highest proportion of podium presentations was by AMGs (48.5%), followed by non-US based (28.3%), IMGs (14.1%), and non-MD (9.1%) speakers. 57% of IMG presentations consisted of original research compared to 48.7% for AMGs (Table). Notably, compared to AMGs, IMGs were significantly less likely to be included in invited faculty roles (odds ratio [OR] 0.72 [95% CI 0.58 – 0.88], p <0.01), a finding that remained significant after accounting for gender and academic rank (adjusted OR 0.75 [0.61 – 0.94], p= 0.01). Conclusions: Relative to IMGs’ original research output, IMGs appear to receive less invitations for ASCO Annual Meeting invited faculty roles compared to AMGs. Our findings suggest potential under-representation and under-recognition of IMGs in these roles, despite their contributions to the oncology workforce in the US. [Table: see text]

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Alvarado-Ramy, Francisco, Elise M. Beltrami, Louise J. Short, Pamela U. Srivastava, Keith Henry, Meryl Mendelson, Julie L. Gerberding et al. « A Comprehensive Approach to Percutaneous Injury Prevention During Phlebotomy : Results of a Multicenter Study, 1993-1995 ». Infection Control & ; Hospital Epidemiology 24, n^o 02 (février 2003) : 97–104. http://dx.doi.org/10.1086/502179.

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Abstract Objective: To examine a comprehensive approach for preventing percutaneous injuries associated with phlebotomy procedures. Design and Setting: From 1993 through 1995, personnel at 10 university-affiliated hospitals enhanced surveillance and assessed underreporting of percutaneous injuries; selected, implemented, and evaluated the efficacy of phlebotomy devices with safety features (ie, engineered sharps injury prevention devices [ESIPDs]); and assessed healthcare worker satisfaction with ESIPDs. Investigators also evaluated the preventability of a subset of percutaneous injuries and conducted an audit of sharps disposal containers to quantify activation rates for devices with safety features. Results: The three selected phlebotomy devices with safety features reduced percutaneous injury rates compared with conventional devices. Activation rates varied according to ease of use, healthcare worker preference for ESIPDs, perceived “patient adverse events,” and device-specific training. Conclusions: Device-specific features and healthcare worker training and involvement in the selection of ESIPDs affect the activation rates for ESIPDs and therefore their efficacy. The implementation of ESIPDs is a useful measure in a comprehensive program to reduce percutaneous injuries associated with phlebotomy procedures.

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Rizk, Emanuelle M., Jiangxia Wang, Xiyu Zhao, Brittany Tsou, Beruk E. Metiku, Katie Cho, Pranav Samineni, Jayanth Sridhar et Fasika A. Woreta. « Rates of Internal Hiring of Ophthalmology Faculty from their Institution of Training at Top Academic Medical Centers : A Cross-Sectional Study ». Journal of Academic Ophthalmology 15, n^o 02 (juillet 2023) : e154-e161. http://dx.doi.org/10.1055/s-0043-1771377.

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Abstract Background Throughout graduate and postgraduate education, trainees need to gauge the impact of training location on future institutions of practice. Objective We assessed rates of internal hiring of ophthalmology faculty at academic institutions from their same institution of training. Methods This was a cross-sectional study. We included 1,246 clinical ophthalmology faculty at the 13 top-ranked institutions listed in the 2021 U.S. News and World Report. Primary, emeritus, adjunct, and affiliate faculty were included. Publicly available information was collected from institutional websites and other online sources. Statistical analyses were conducted using t-tests or Mann–Whitney tests, chi-squared or Fisher's exact tests, and multivariate logistic regression. The main outcome measured was internal hires, defined as faculty who had completed residency and/or fellowship training at their current institution. Results In total, 47.3% of faculty were internal hires who completed residency or fellowship at the same institution. Among externally trained faculty, 27.7% completed residency and 56.0% completed fellowship at another top 13 programs. Internal hires were more frequently fellowship-trained, had a greater number of publications, and practiced in smaller departments (p < 0.001, p < 0.001, and p = 0.002, respectively). A greater proportion of internal hires held leadership positions (p = 0.012). Faculty practicing in the Midwest or West and with more years since residency graduation were less likely (odds ratio [OR], 0.29, 95% confidence interval [CI], 0.18–0.48; OR, 0.49, 95% CI, 0.31–0.78; OR, 0.98, 95% CI, 0.97–0.99, respectively) to be internal hires. Faculty with non-R01 National Institutes of Health funding were more likely to be internal hires (OR, 1.82, 95% CI: 1.12–2.96). Conclusions Training institution is key to determining the institution of practice. These results may be beneficial for trainees to consider when selecting a training program.

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Kholood Mohammad Almassadeh, Kholood Mohammad Almassadeh. « Students Mistakes Analysis of the Tenth- Grade in Interpretation Verbal Expressions into Algebraic Equations and Quantities : تحليل أخطاء طلبة الصّف العاشر الأساسي في ترجمة التعابير اللفظية إلى معادلات ومقادير جبرية ». مجلة العلوم التربوية و النفسية 5, n^o 51 (30 décembre 2021) : 37–16. http://dx.doi.org/10.26389/ajsrp.d130621.

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The study aims to detecting the mistakes of the tenth- grade student's interpretation verbal expressions into algebraic equations and quantities and vice versa, identify and analyze common students’ mistakes. The researcher used the descriptive approach and applied the study to a sample that formed of (100) female students of the tenth grade from Fatima Bint Al Khattab Secondary School, that affiliated to the Directorate of Education for First Zarqa District. A test was prepared - in two models, each model included 3 paragraphs - in phrasing of algebraic equations and quantities and vice versa into verbal expressions and vice versa, and it was applied to two divisions of the tenth- grade. The results have indicated to a classification of students' most common mistakes at the level of all test items, which were arranged in descending order: Common mistakes in interpretation the verbal phrases of addition, subtraction or multiplication into algebraic symbols: repeated by (39%) within the six test paragraphs, followed by mistakes in mathematical concepts, repeated by (29%), followed by the mistake: Confusion between an equation and an algebraic expression, repeated by (25%). The study also found, through checking the percentages of common mistakes, that the students were unimproved in an interpretation the verbal formulation within a story or phrase into algebraic symbols, or formulating equations or algebraic expressions in a verbal phrase, in a story or a life’s situation. In light of the results, several recommendations were suggested, the most important were as following: Application and execution of the teachers for the teaching strategy by using common students’ mistakes, and the committees based on curriculum development and design should take into account the selection of appropriate words for each age group, when phrasing verbal mistakes, and to ensure that they are linguistically and orthographically correct. Based on the development and design of curricula, choosing appropriate words for each age group, when formulating verbal mistakes, and ensuring that they are linguistically and orthographically correct. It was also proposed to hold training courses for teachers, in order to train them on the use of the developed programs to address common students' mistakes in mathematics, such as Drive program and Roll Space program.

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Kashif, Mehwash, Ayesha Aslam, Uzma Zareef, Sana Iqbal, Shama Mashood et Tauseef Ahmed. « The Necessity to Review Oral Pathology Curriculum : A need of time ». Pakistan Journal of Medical and Health Sciences 15, n^o 8 (26 août 2021) : 1995–98. http://dx.doi.org/10.53350/pjmhs211581995.

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Aim: To assess the necessity to review the Oral pathology curriculum, based on the expert opinion of faculty members of oral pathology of Karachi. Methods: In this cross-sectional study the data was collected by non-probability sampling technique from different colleges of Karachi. Distribution of the online questionnaire regarding curriculum of oral pathology was made through Google online forms. Questionnaire was only filled by oral pathology specialists/ experts/faculty of dental colleges of different cities after taking their verbal consent. Inclusion criteria was Oral pathology faculty members from all Pakistan Medical Council affiliated colleges having undergraduate BDS program. Results: Males were 22(66.7%). Among the respondents, 40.62% were Assistant Professor, followed by Demonstrator 31.25% and Associate professor 28.12%. Among participants, approximately 13(39.4%) agreed that the PMC syllabus is non-specific. Topic selection is difficult for 12(36.4%) participants. About 21(63.6%) thought that an extensive Oral Pathology syllabus is needed. Reviews for the inclusion of general pathology topics scored 14(42.4%) disagreement. About 11(33.3%) reported having missing Oral Pathology topics in the curriculum. Majority 18(54.5%) agreed to revise the curriculum. Conclusion: It has been concluded that faculty members of oral pathology recommend a high necessity to review the Oral pathology curriculum in Pakistan. By gathering modifications within the existing program of curriculum, it can be made more intriguing and systematized for students. Keywords: Oral pathology, curriculum, cross-sectional, study

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Haerazi, Haerazi. « ICT integration into English language teaching-learning : Insights from some private higher education institutions ». Englisia : Journal of Language, Education, and Humanities 11, n^o 2 (30 avril 2024) : 48. http://dx.doi.org/10.22373/ej.v11i2.19913.

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The integration of technology within language classrooms is a pivotal facet of modern education. Due to this, this study aims to investigate the English lecturers’ views about the use of educational technology in English language classrooms and the English teachers’ implementation strategies about ICT integration into ELE programs in higher education. The study employs a qualitative research approach to facilitate an in-depth exploration and elucidation of its findings. The participants under scrutiny consisted of English lecturers affiliated with English language education study programs situated within private universities located in the West Nusa Tenggara region. The selection of participants was facilitated through the utilization of a convenient sampling method, which was deemed appropriate for the purposes of data collection in this study. In total, the study encompassed the involvement of 25 participants, and it is noteworthy to mention that the composition of this participant pool exhibited certain demographic characteristics. This study used semi-structured interview guidelines as the research instruments. The data analysis process encompassed several key stages, including data condensation, data display, and drawing conclusions. The research findings highlight a diverse landscape of ICT integration among English lecturers in private universities in West Nusa Tenggara, Indonesia. While some educators demonstrate a propensity for innovative and multifaceted technology integration, others exhibit more conventional and hardware-focused approaches. It can be concluded that English lecturers have views about the technology use that should be optimized in the ICT integration within English language education programs.

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Grubenhoff, Joseph A., Sonja I. Ziniel, Lalit Bajaj et Daniel Hyman. « Pediatric faculty knowledge and comfort discussing diagnostic errors : a pilot survey to understand barriers to an educational program ». Diagnosis 6, n^o 2 (26 juin 2019) : 101–7. http://dx.doi.org/10.1515/dx-2018-0056.

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Abstract Background Improving Diagnosis in Healthcare calls for improved training in diagnostic reasoning and establishing non-judgmental forums to learn from diagnostic errors arising from heuristic-driven reasoning. Little is known about pediatric providers’ familiarity with heuristics or the culture surrounding forums where diagnostic errors are discussed. This study aimed to describe pediatric providers’ familiarity with common heuristics and perceptions surrounding public discussions of diagnostic errors. Methods We surveyed pediatric providers at a university-affiliated children’s hospital. The survey asked participants to identify common heuristics used during clinical reasoning (five definitions; four exemplar clinical vignettes). Participants answered questions regarding comfort publicly discussing their own diagnostic errors and barriers to sharing them. Results Seventy (30.6% response rate) faculty completed the survey. The mean number of correctly selected heuristics was 1.60/5 [standard deviation (SD)=1.13] and 1.01/4 (SD=1.06) for the definitions and vignettes, respectively. A low but significant correlation existed between correctly identifying a definition and selecting the correct heuristic in vignettes (Spearman’s ρ=0.27, p=0.02). Clinicians were significantly less likely to be “pretty” or “very” comfortable discussing diagnostic errors in public vs. private conversations (28.3% vs. 74.3%, p<0.01). The most frequently cited barriers to discussing errors were loss of reputation (62.9%) and fear of knowledge-base (58.6%) or decision-making (57.1%) being judged. Conclusions Pediatric providers demonstrated limited familiarity with common heuristics leading to diagnostic error. Greater years in practice is associated with more comfort discussing diagnostic errors, but negative peer and personal perceptions of diagnostic performance are common barriers to discussing errors publicly.

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Kuspriyadi, Indra, Marlina Widiyanti, Aslamia Rosa et Muchsin Saggaff Shihab. « influence of product quality and digital marketing on the performance of SMEs ». International journal of business, economics & ; management 6, n^o 4 (26 décembre 2023) : 296–303. http://dx.doi.org/10.21744/ijbem.v6n4.2228.

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This research explores the intricate dynamics between product quality, digital marketing strategies, and Small and Medium Enterprises (SMEs) performance. The study focuses on the entire population of 43 SMEs affiliated with the Representative Office of Bank Indonesia in South Sumatra Province in 2022. These SMEs benefit from comprehensive guidance provided by Bank Indonesia consultants and actively participate in mentoring programs spanning both conventional and Sharia SME schemes, reflecting a census-based sample selection. The findings derived from multiple linear regression analysis underscore a noteworthy positive and significant impact of product quality and digital marketing on SME performance. In a marketplace saturated with similar products in South Sumatra Province, SMEs must cultivate distinctive attributes that resonate with the local community, thus enhancing their competitive edge. Additionally, the geographical remoteness of SMEs from the city center emerges as a pivotal factor influencing their performance. This remoteness not only affects production logistics but also poses challenges to sales, thereby shaping the overall performance landscape of these enterprises. In essence, this research contributes valuable insights into the multifaceted relationship between product quality, digital marketing strategies, and the performance of SMEs, particularly those aligned with Bank Indonesia in South Sumatra Province.

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Sato, Kazuhiko, Nobuaki Shinozaki, Masaru Iwai, Yoshio Mizuno, Rai Shimoyama, Noriyuki Takahashi et Yoshiro Niitsu. « Web-based standard-regimen selection (SRS) and cancer-care registry (CCR) systems of a nationwide network in Japan : An attempt to improve breast cancer treatment. » Journal of Clinical Oncology 30, n^o 27_suppl (20 septembre 2012) : 76. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.76.

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76 Background: Tokushukai group has a nation-wide network of 67 affiliated hospitals, and has started an “oncology project” to improve the quality of cancer care using web-based SRS and CCR systems. Methods: Every institution has been introduced the same electric-medical-record (EMR) to share the unified code to order chemotherapy regimens, and patient data could be collected on a database in the central office. 141 recommended regimens for 15 types of solid tumor have been approved in the cancer committee consisting of working-group and program-evaluation members. In breast cancer, 31 recommended regimens (7 for adjuvant and 24 for metastatic settings) were selected from the NCCN guidelines and approved by the committee. Not only recommended but also non-recommended regimens have their own specific codes in EMR, and the patterns of care in the selection of chemotherapy regimen were examined. Results: In 2011, 21 of 67 hospitals utilized these systems. 71.8% of 2,676 patients with cancer including 753 with colorectal, 317 with breast, 273 with gastric, 144 with non-small cell lung, 123 with pancreatic, and 73 patients with esophageal cancer had received 97 types of recommended therapies (11,022 cycles). In terms of breast cancer, 86% of 388 patients had been treated with recommended regimens (1,994 cycles). Among 71 patients received non-recommend therapies, only 6 patients (1.5%) had been treated with three regimens which were not regarded as standard regimens. Conclusions: The introduction of web-based SRS and CCR systems in a large medical group could facilitate standard chemotherapy regimen by an accurate examination of current treatment patterns.

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McCurley, Jessica L., Vicki Fung, Douglas E. Levy, Sydney McGovern, Christine Vogeli, Cheryl R. Clark, Stephen Bartels et Anne N. Thorndike. « Assessment of the Massachusetts Flexible Services Program to Address Food and Housing Insecurity in a Medicaid Accountable Care Organization ». JAMA Health Forum 4, n^o 6 (2 juin 2023) : e231191. http://dx.doi.org/10.1001/jamahealthforum.2023.1191.

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ImportanceHealth systems are increasingly addressing health-related social needs. The Massachusetts Flexible Services program (Flex) is a 3-year pilot program to address food insecurity and housing insecurity by connecting Medicaid accountable care organization (ACO) enrollees to community resources.ObjectiveTo understand barriers and facilitators of Flex implementation in 1 Medicaid ACO during the first 17 months of the program.Design, Setting, and ParticipantsThis mixed-methods qualitative evaluation study from March 2020 to July 2021 used the Reach, Efficacy, Adoption, Implementation, Maintenance/Practical, Robust Implementation, and Sustainability Model (RE-AIM/PRISM) framework. Two Mass General Brigham (MGB) hospitals and affiliated community health centers were included in the analysis. Quantitative data included all MGB Medicaid ACO enrollees. Qualitative interviews were conducted with 15 members of ACO staff and 17 Flex enrollees.Main Outcomes and MeasuresReach was assessed by the proportion of ACO enrollees who completed annual social needs screening (eg, food insecurity and housing insecurity) and the proportion and demographics of Flex enrollees. Qualitative interviews examined other RE-AIM/PRISM constructs (eg, implementation challenges, facilitators, and perceived effectiveness).ResultsOf 67 098 Medicaid ACO enrollees from March 2020 to July 2021 (mean [SD] age, 28.8 [18.7] years), 38 442 (57.3%) completed at least 1 social needs screening; 10 730 (16.0%) screened positive for food insecurity, and 7401 (11.0%) screened positive for housing insecurity. There were 658 (1.6%) adults (mean [SD] age, 46.6 [11.8] years) and 173 (0.7%) children (&lt;21 years; mean [SD] age, 10.1 [5.5]) enrolled in Flex; of these 831 people, 613 (73.8%) were female, 444 (53.4%) were Hispanic/Latinx, and 172 (20.7%) were Black. Most Flex enrollees (584 [88.8%] adults; 143 [82.7%] children) received the intended nutrition or housing services. Implementation challenges identified by staff interviewed included administrative burden, coordination with community organizations, data-sharing and information-sharing, and COVID-19 factors (eg, reduced clinical visits). Implementation facilitators included administrative funding for enrollment staff, bidirectional communication with community partners, adaptive strategies to identify eligible patients, and raising clinician awareness of Flex. In Flex enrollee interviews, those receiving nutrition services reported increased healthy eating and food security; they also reported higher program satisfaction than Flex enrollees receiving housing services. Enrollees who received nutrition services that allowed for selecting food based on preferences reported higher satisfaction than those not able to select food.Conclusions and RelevanceThis mixed-methods qualitative evaluation study found that to improve implementation, Medicaid and health system programs that address social needs may benefit from providing funding for administrative costs, developing bidirectional data-sharing platforms, and tailoring support to patient preferences.

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AlFattani, Areej, Fatimah Rabhan, Lujain AlAssaf, Amal Alghammas et Edward De Vol. « National Survey about awareness of Primary Immunodeficiency Disorders among Primary Care Physicians in Saudi Arabia : Protocol and Challenges ». Journal of Primary Care & ; Community Health 11 (janvier 2020) : 215013272095128. http://dx.doi.org/10.1177/2150132720951288.

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Introduction: Primary Health Care Centers (PHCC) are the first contact health facility to which patients in Saudi Arabia can go to seek help. Primary Immunodeficiency Disorders (PIDD) are of various types and severities, and they are associated with a delay in diagnosis. Early diagnosis of PIDD helps to improve the quality of life of affected children and prevent permanent consequences such as organ damage and disability. In this study, we present a protocol of a national survey that assesses awareness among PHCC physicians about diagnosing PIDD and the challenges associated with the execution of this protocol. Methods: This cross-sectional survey used stratified multistage sampling and systematic random selection of PHCC from a list of PHCC affiliated centers under the Ministry of Health (MOH) in Saudi Arabia. The survey was conducted through phone calls to the selected physicians. Data collection started in April 2020, and it is still ongoing. Conclusion: In Saudi Arabia, this study will provide baseline data about PHCC physicians’ levels of awareness of the diagnosis of PIDD. This will help policy-makers in designing educational courses or programs to increase awareness levels among physicians. The protocol could be used to study other health outcomes at a national level.

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DOGAN, Soner, Yücel OKTAY et Emine Tunçer GÜNAY. « Teaching Profession Law According to the Perspective of Union Representative Teachers ». Journal of Qualitative Research in Education, n^o 37 (30 janvier 2024) : 220–46. http://dx.doi.org/10.14689/enad.37.1659.

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This study, which aims to analyze the Teaching Profession Law in terms of purpose, content and innovations, according to the opinions of teachers, was designed according to the phenomenology pattern. The study was determined by the criterion sampling method. The working group consisted of six workplace representatives of the three education unions affiliated to the Ministry of National Education and three teachers. A semi-structured interview form consisting of open-ended questions developed by the researchers was used. Content analysis method was used in the analysis of the research data. According to the results, participants find the law insufficient for reasons such as limited content, insufficient improvement of personal rights, not determining the general competencies, teachers' lack of access to professional development programs, not approaching the teaching holistically, and not meeting the needs and demands of teachers. Participants stated that the Law did not meet the expectations regarding the selection, training and on-the-job training of teachers, and that the teaching career steps did not provide teachers with the motivation to improve themselves. It has been concluded that the issues of "supervision and guidance system" and "professional ethics" are not included in the Teaching Profession Law, which is an important deficiency.

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Kaplan, Barbara, Nancy A. Mason, Leslie A. Shimp et Frank J. Ascione. « Chronic Hemodialysis Patients. Part I : Characterization and Drug-Related Problems ». Annals of Pharmacotherapy 28, n^o 3 (mars 1994) : 316–19. http://dx.doi.org/10.1177/106002809402800303.

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OBJECIVE: To describe medication use in hemodialysis patients and to characterize the potential drug-related problems that may occur in this population. DESIGN: All patients being dialyzed during the study period who were responsible for taking their own medications and who were able to provide an accurate medication history were included in this study. A pharmacist administered a structured medication history and drug therapy review protocol known as the Focused Drug Therapy Review Program to identify potential drug-related problems. This process was modified for a hemodialysis population. SETIING: Outpatient hemodialysis unit at a university-affiliated hospital. RESULTS: Thirty patients with endstage renal disease requiring hemodialysis were enrolled in the study. On average, 10 prescription and 2 prescribed nonprescription medications were used per patient. The incidence of potential adverse effects and medication allergies or intolerances averaged 5.5 and 2.2 per patient, respectively. Twenty patients (67 percent) reported missing an average of 3.4 (range I-II) doses of medication per month. A total of 216 potential drug-related problems (encompassing both prescribing choices and patient behaviors) were identifiedby the pharmacist; the categories of drug selection and medication compliance contained the greatest number of potential problems (24 and 23 percent, respectively). CONCLUSIONS: Hemodialysis patients use a large number of medications, which increases the risk for adverse reactions and other drug-related problems. The types of potential drug-related problems identified are amenable to pharmacist input. Thus, such patients should be targeted for clinical pharmacy intervention.

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Buinytska, Oksana, et Svitlana Vasylenko. « USING E-COURSES TO ENHANCE THE FUTURE TEACHERS` DIGITAL COMPETENCE ». OPEN EDUCATIONAL E-ENVIRONMENT OF MODERN UNIVERSITY, SPECIAL EDITION (2018) : 44–62. http://dx.doi.org/10.28925/2414-0325.2019s5.

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The article presents the experience of developing the digital competence level as one of the main components of future teachers’ success, including the implementation of STEAM education in the educational process of secondary education institutions. An overview of modern scientific publications was performed, mainly published by foreign researchers and also by researchers from Ukraine, which define the concept of digital competence, reveal different approaches to determine the level of digital competence of future specialists using the digital competence wheel; STEAM education and digital competence communication, formed enough to integrate STEAM principles into the educational process of secondary education institutions. The author presents the results of the implementation e-learning courses, that were developed for key disciplines in the specialization «Management of e-learning in the intercultural space» and joint research of IT in Education Laboratory staff, teachers of the Department of Computer Science and Mathematics and students of the Pedagogical Institute of Borys Grinchenko Kyiv University on training courses to enhance the digital competence of future teachers. The description of the two key disciplines of the e-learning course presents information on the development of integrated, professional and digital competences. While updating the content and selection of teaching methods, the recommendations and articles issued in the framework of the project «Modernization of Pedagogical Higher Education through the Use of Innovative Teaching Instruments» (MoPED) of the EU program Erasmus + KA2 – Development of Higher Education Capacity, No. 586098-EPP- 1-2017-1-UA-EPPKA2-CBHE-JP, JP, which is affiliated with Borys Grinchenko Kyiv University, are included.

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JPT staff, _. « E&P Notes (December 2021) ». Journal of Petroleum Technology 73, n^o 12 (1 décembre 2021) : 14–16. http://dx.doi.org/10.2118/1221-0014-jpt.

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Sinopec Signals Fresh Shale Success With Dongye Deep 2 Sinopec has announced that the Dongye Deep 2 key shale gas well in Dongxi, Chongqing, was drilled to a total depth of 4300 m and tested at 412000 m3/d of high-quality natural gas. The operator said the result shows significant progress in ultradeep shale gas exploration in China and will increase Sinopec’s shale gas production capacity in southeast Sichuan by more than 2 trillion m3. Following the breakthrough of the Fuling shale gas field in 2012, Sinopec has been expanding its expertise in deep shale gas. In 2018, Sinopec discovered and commercialized the Weirong shale gas field at a depth of 3800 m. The technical requirements of developing deep marine shale gas reservoirs at depths exceeding 4000 m are high due to challenges faced at ultrahigh depths and complex crustal stress. Sinopec plans to increase oil and gas exploration by developing unconventional resources such as shale oil and gas while focusing on growing reserves and production of conventional petroleum. Qatar Energy Farms Into Hampden License off Eastern Canada Qatar Energy has signed an agreement with ExxonMobil Canada to acquire a 40% ownership of exploration license 1165A off Canada’s east coast, marking the state-owned oil company’s first foray into offshore exploration in Canada. The Block EL 1165A is where operator ExxonMobil plans to drill the deepwater Hampden exploration well sometime in 2022. In May 2020, Seadrill semisubmersible rig West Aquarius began drilling for ExxonMobil at the Hampden prospect, but operations were suspended after a week, without explanation. ExxonMobil is said to be nearing a deal for a rig to complete the exploration well. Qatar is the world’s largest supplier of liquefied natural gas, or LNG, and is undertaking a strategy to boost production significantly over the next 5 years to meet the growing market for LNG. ExxonMobil led the way in developing Newfoundland and Labrador’s offshore, and operates both the Hibernia and Hebron oil fields. The oil major has been broadening its attention to the Flemish Pass Basin, a frontier area where other major discoveries have been made, including Equinor’s Bay du Nord find. TGS Plans 3D Shoot Offshore Suriname TGS, in a consortium with CGG and BGP, have signed a multiclient agreement with Staatsolie, the state-owned company leading the development of the energy industry in the Republic of Suriname. The deal allows for the acquisition, promotion, and licensing of multiclient seismic programs, including new 3D acquisition and legacy data reprocessing, in the shallow-water acreage offshore Suriname. Suriname’s acreage includes three blocks recently awarded, and current open acreage slated to be offered, in a competitive bid round for 2023. The new seismic data from the consortium’s programs can be used to delineate the prospectivity and potential of this underexplored area and is on trend with the recent material discoveries announced on the prolific Block 58. Plans are in place to start acquiring the new 3D seismic data in the area prior to year-end, with first products to be made available during the first half of 2022. BGP Offshore will deploy its 3D vessel BGP Prospector in phase 1 of the project. ExxonMobil Increases Stabroek Resource Estimate Again ExxonMobil has increased the estimated overall resource at its Stabroek Block offshore Guyana to around 10 billion bbl, reflecting the recent exploration success at its Cataback prospect. The Cataback-1 well encountered 243 ft of net pay in high-quality hydrocarbon-bearing sandstone reservoirs. The find is located approximately 3.7 miles east of Turbot-1 and was drilled in 5,928 ft of water by the drillship Noble Tom Madden. Success at Cataback brings the total significant discoveries to more than 20 within the Stabroek Block. The Stabroek Block spans 6.6 million acres. ExxonMobil affiliate Esso Exploration and Production Guyana Limited is operator and holds 45% interest in the block. Hess Guyana Exploration holds 30% interest, and CNOOC Petroleum Guyana Limited holds the remaining 25% stake. Shell To Sign PSA on Trindad’s Manatee Discovery Royal Dutch Shell expects to sign a production-sharing contract for the 2.7-Tcf Manatee offshore gas field in Trinidad and Tobago. The country’s Energy Minister Stuart Young confirmed the contract has been negotiated and is hoping the operator signs on in the coming weeks. The field is part of the 10-Tcf Loran-Manatee complex that straddles Trinidad and Tobago’s maritime border with Venezuela. Young said it “is going to be the single largest new gas production contract and gas production in TT [Trinidad and Tobago] for decades.” Gas volumes could start flowing as early as 2025, but this depends on the speed at which the parties can install infrastructure. Production rates from the field are expected to range from 270 million to 400 MMcf/D. US sanctions against the regime of Venezuela’s Nicolás Maduro prevented co-development of the complex. Lundin Increases Stake in Wisting Lundin Energy has entered into an agreement with OMV to acquire its entire 25% working interest in the Wisting development in the southern Barents Sea for $320 million. The acquisition takes Lundin Energy’s working interest to 35% in the 500-MMBO development. In addition to the 35% stake in Wisting, Lundin Energy also holds surrounding acreage which is estimated to hold gross unrisked prospective resources of a further 500 MMBO. Wisting will be one of the largest development projects in Norway over the next few years, to become the next Barents Sea production hub, according to Lundin. Concept selection is anticipated shortly, and the submission of the Plan of Development and Operation is targeted by year-end 2022 to qualify for the temporary tax incentives established by the Norwegian government in June 2020. With first oil scheduled for 2028, the acquisition provides a material contribution to sustaining the company’s production in the long term. The Wisting development is also planned to have power supplied from shore, which is aligned with the company’s decarbonization strategy and its commitment to becoming carbon neutral by 2023. The transaction, which has an effective date of 1 January 2021, is subject to the customary Norwegian regulatory approvals, and is expected to complete during Q4 2021. The other partners in Wisting are Equinor, the development-phase operator, with a 35% working interest, Petoro with a 20% working interest, and Idemitsu with a 10% stake. Panoro Energy Awarded Stakes Offshore Gabon Panoro Energy has provisionally been awarded a 25% nonoperated interest in exploration blocks G12-13 and H12-13 offshore shallow-water Gabon following the 12th Offshore Licensing Round. The award remains subject to final agreement of the terms of the production-sharing contracts with the government of Gabon. Partners in the blocks will include BW Energy (37.5% and operator) and VAALCO Energy (37.5%). Blocks G12-13 and H12-13 cover a surface area of 2989 km2 and 1929 km2, respectively, and are adjacent to the producing Dussafu Marin Permit, in which Panoro holds a 17.5% interest and is partnered with BW Energy. The G12-13 block is also adjacent to the producing Etame Marin license operated by VAALCO Energy. Panoro expects the contracts over the two blocks will have an exploration period of 8 years with an option to extend by another 2 years. During the exploration period, the partners intend to carry out a work program which may include reprocessing of existing seismic, new seismic acquisition, and exploration drilling.

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de Laplante, Jean. « La recherche au service de l'éducation syndicale ». Relations industrielles 12, n^o 3 (13 février 2014) : 238–43. http://dx.doi.org/10.7202/1022569ar.

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Summary Four years ago, the National Union of Municipal Employees of the City of Montreal, affiliated to the C.C.C.L., established an education service which has made interesting and valuable efforts to improve the training of its members. This selection was taken for indirect reasons: the increasing effort towards education in trade unionism in general; the growing interest of people in education and the development of consciousness among the City Hall personnel for the urgency of education. There also were direct reasons: the vigilant action of the union itself to favour the personal development of its members; the climate reigning at the City Hall, and the attitude of the Union towards the civic authorities. Before getting into action, everyone decided that some thinking and discussion was in order; so the group responsible for educational activities was supported by the union leaders and strongly encouraged. Every member was convinced that education should promote the human person, develop his consciousness and make him accept his responsibilities. First of all, one must know oneself in order to be integrated into society; science and techniques are very useful and must not be neglected; in and of themselves, however, they are unable to shape man. For the last two years, the themes inspiring the education program have been: "Conscience and competence of the unionized civic employee", and "Development of the personal initiative and of the sense of responsibilities". To realize its objectives, the group makes use of various techniques: study circle, union paper, union meetings, and luncheon meetings; it has also added a union practices workshop and a course for professional betterment in cooperation with the University of Montreal. Almost 300 unionized civic employees attended these sessions and paid their own fees; the union offered 50 scholarships. The methods of education used are simple, and the efforts made are on a collective basis. The key to its surprising success is group work and group decision-making. A research study has been undertaken and published in order to appreciate the value of the methodological technique used and to be used successfully in the elaboration and application of an educational program for civic employees.

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Yan, Nie, Lu Zinan et Gang Sun. « Predicting survival and prognosis of postoperative breast cancer brain metastasis : A population-based retrospective analysis. » Journal of Clinical Oncology 41, n^o 16_suppl (1 juin 2023) : e14011-e14011. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e14011.

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e14011 Background: The study aimed to construct a novel predictive clinical model to evaluate the overall survival (OS) of patients with postoperative brain metastasis of breast cancer (BCBM) and validate its effectiveness. Methods: From 2010 to 2020, a total of 310 female patients with BCBM were diagnosed in The Affiliated Cancer Hospital of Xinjiang Medical University, and were randomly assigned to the training cohort and the validation cohort. Another 173 BCBM patients were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database as an external validation cohort. In the training cohort, the least absolute shrinkage and selection operator (LASSO) Cox regression model was used to determine the fundamental clinical predictive indicators and the nomogram was constructed to predict OS. The model capability was assessed using receiver operating characteristic, C-index, and calibration curves. Kaplan–Meier survival analysis was performed to evaluate clinical effectiveness of the risk stratification system in the model. The accuracy and prediction capability of the model were verified using the validation and SEER cohorts. Results: LASSO Cox regression analysis revealed that lymph node metastasis, molecular subtype, tumor size, chemotherapy, radiotherapy, and lung metastasis were statistically correlated with BCBM. The C-indexes of the survival nomogram in the training, validation, and SEER cohorts were 0.714, 0.710, and 0.670, respectively, which showed good prediction capability. The calibration curves demonstrated that the nomogram had great forecast precision, and a dynamic diagram was drawn to increase the maneuverability of the results. The R showed that the OS of low-risk patients was considerably better than that of high-risk patients ( P <0.001). Conclusions: The nomogram prediction model constructed in this study has a good predictive value, which can effectively evaluate the survival rate of patients with postoperative BCBM.

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Blau, Sibel, Julio Antonio Peguero, Halle C. F. Moore, Ian Churchill Anderson, Minal A. Barve, Mathew Amprayil Cherian, Ahmed Elkhanany et al. « Operational metrics for the ELAINE II study combining a traditional approach with a just-in-time model. » Journal of Clinical Oncology 40, n^o 16_suppl (1 juin 2022) : 1504. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1504.

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1504 Background: Trial recruitment that requires specific actionable mutations based on next-generation sequencing (NGS) is challenging. Barriers can include competing studies, physician study awareness, site proximity, mutation incidence, among other concerns. Methods: This study (NCT04432454) opened clinical sites using two methods during the COVID-19 pandemic. The “Traditional” approach included site selection, IRB and contract approval, and trial activation prior to a patient being identified for enrollment. The second approach used the Tempus “TIME” Trials network that would only open a site after identifying a patient with a mutation of interest and eligible for the trial. Results: The first patient enrolled was on 10/12/20 and the last patient was on 6/24/21. A total of 16 sites (6 Traditional and 10 TIME) participated. All Traditional sites, and none of the TIME sites, were affiliated with major academic institutions. Duration for full CTA execution for Traditional sites averaged 200.5 days (range 142 to 257) and for TIME sites averaged 7.6 days (range 2 to 14). IRB approval time average for Traditional sites was 27.5 days (range 12 to 71) and TIME sites was 3.0 days (range 1 to 12 days). Days from site selection to activation letter for Traditional sites was on average 250.0 days (range 187 to 281) and for TIME sites was 131.6 days (range 22 to 248). Time from study activation to first consent was 33.3 days (range 18 to 58) for Traditional sites and 8.8 days (range 1 to 35) for TIME sites. The first patient on-study was at a TIME site 115 days prior to a Traditional site and the first 7 patients enrolled were at TIME sites. Traditional sites consented 23 and enrolled 16 patients while the TIME sites consented 16 and enrolled 13. The trial enrolled all 29 patients in 8 months with the anticipated enrollment duration being 12 to 18 months. Conclusions: Although the Traditional and TIME programs had different operational models, they both contributed a significant number of patients and reduced the projected enrollment timeline. TIME sites enrolled the initial patients. These results demonstrate that the “Just-in-Time model,” in conjunction with a Traditional model, can reduce projected overall time to enrollment in biomarker-driven studies. [Table: see text]

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García-Hernández, C., J. Ruiz-Fernández et E. Serrano-Cañadas. « Social network analysis in Geosciences : scientific collaboration between periglacial scholars in the Iberian Peninsula ». Cuadernos de Investigación Geográfica 46, n^o 1 (24 juin 2020) : 319–39. http://dx.doi.org/10.18172/cig.3939.

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This research examines the collaboration relationships between those authors affiliated to Iberian institutions and involved in periglacial studies between 2000 and 2017. The data has been extracted from the Google Scholar database and processed using Social Network Analysis (SNA) techniques. A total of 230 scientific publications have been selected, involving 198 researchers of which 113 belong to Spanish institutions, 38 to Portuguese institutions and 47 to foreign institutions. The work carried out by the Iberian community (assembled through national groups linked to the International Permafrost Association) has considerably improved its possibilities of dissemination and citation in this period: There has been an increase in the number of publications per year, in the number of authors per publication, and in the number of publications with international collaboration. Nowadays there is a group of very productive and well-connected authors, who play an important role as intermediaries, and future prospects are good. However, 50% of the authors have a low capacity for interaction, and there is a low presence of women in the network: These imbalances should constitute the main challenges to be faced by the Iberian community in the next decade. Beyond the Iberian community of periglacial scholars, this study provides an example of methodology to be applied in other co-authorship networks in subdisciplines of the Earth Sciences, and its results are discussed in this sense. The results of this research offer valuable information for the management of scientific collaboration programs, the selection of representatives and to weigh the possibilities and needs of the Iberian network. But, especially, it presents a socioscientific framework of reference for early career scientists and makes them aware of the need to integrate themselves into a booming scientific community.

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Huang, Joanne, Zahra Kassamali Escobar, Rupali Jain, Jeannie D. Chan, John B. Lynch, Marisa A. D’Angeli, Victoria Fang, Larissa May et Chloe Bryson-Cahn. « 131. Antimicrobial Usage for Respiratory Infections in Urgent Care Settings within the University of Washington Medicine Network ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S77. http://dx.doi.org/10.1093/ofid/ofaa439.176.

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Abstract Background In an effort to combat antimicrobial resistance and adverse drug events, The Joint Commission mandated expansion of antimicrobial stewardship programs into ambulatory healthcare settings Jan 2020. The most common diagnoses resulting in inappropriate antimicrobial prescribing are respiratory infections. This study aimed to assess the rate of antibiotic prescribing for viral respiratory tract infections within six urgent care clinics affiliated with University of Washington Medicine health system in Seattle, WA. Methods This was a retrospective observational study from Jan 2019-Feb 2020. We used the MITIGATE toolkit; a resource that meets CDC’s core elements for outpatient stewardship. Patients were identified based upon pre-specified ICD-10 codes for viral respiratory infections. The primary outcome was the rate of unnecessary antimicrobial prescriptions for acute viral respiratory infections. Secondary outcomes evaluated inappropriate prescribing practices based on antibiotic selection, diagnosis, and age. Results Of 7,313 patients (6078 adults and 1235 pediatric) included, 23% were inappropriately prescribed antibiotics. The most common antibiotics inappropriately prescribed were azithromycin (62%), amoxicillin (13%), and doxycycline (13%). Fluoroquinolone (FQ) utilization was low (2%). Bronchitis (61%) and nonsuppurative otitis media (NSOM) (24%) were the most common viral diagnoses for which antibiotics were prescribed. Overall, unnecessary prescribing was lower in pediatrics than adults at 13% and 25%, respectively (p< 0.001). Adults were more often prescribed antibiotics inappropriately for bronchitis and NSOM compared to pediatrics (p=0.0013). Conclusion Inappropriate prescribing practices across six urgent care clinics varied based upon age and diagnosis. Azithromycin is most often inappropriately prescribed but the low rate of FQ prescribing is encouraging. The lower rate of unnecessary prescribing in pediatrics is promising although there is room for improvement as 1 in 8 children were unnecessarily prescribed antibiotics. These findings support the need for antibiotic stewardship in the outpatient setting, targeting areas for azithromycin use and therapeutic management of bronchitis. Disclosures All Authors: No reported disclosures

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Bjegovich-Weidman, Marija, Jill Kahabka, Amy Bock, Jacob Frick, Helga Kowalski et Joseph Mirro. « Development by a Large Integrated Health Care System of an Objective Methodology for Evaluation of Medical Oncology Service Sites ». Journal of Oncology Practice 8, n^o 2 (mars 2012) : 70. http://dx.doi.org/10.1200/jop.2011.000425.

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Purpose: Aurora Health Care (AHC) is the largest health care system in Wisconsin, with 14 acute care hospitals. In early 2010, a group of 18 medical oncologists became affiliated with AHC. This affiliation added 13 medical oncology infusion clinics to our existing 12 sites. In the era of health care reform and declining reimbursement, we need an objective method and criteria to evaluate our 25 outpatient medical oncology sites. We developed financial, clinical, and strategic tools for the evaluation and management of our cancer subservice lines and outpatient sites. The key to our success has been the direct involvement of stakeholders with a vested interest in the services in the selection of the criteria and evaluation process. Methods: We developed our objective metrics for evaluation based on strategic, financial, operational, and patient experience criteria. Strategic criteria included: population trends, full-time equivalent (FTE) medical oncologists/primary care physicians, FTE radiation oncologists, FTE oncologic surgeons, new annual cases of patients with cancer, and market share trends. Financial criteria per site included: physician work relative value units, staff FTE by type, staff salaries, and profit and loss. Operational criteria included: facility by type (clinic v hospital based), hours of operation, and facility detail (eg, No. of chairs, No. of procedure and examination rooms, square footage). Patient experience criteria included: nursing model primary/nurse navigators, multidisciplinary support at site, Press Ganey (South Bend, IN; health care performance improvement company) results, and employee engagement score. Results: The outcome of our data analysis has resulted in the development of recommendations for AHC senior leadership and geographic market leadership to consider the consolidation of four sites (phase one, four sites; phase two, two sites) and priority strategic sites to address capacity issues that limit growth. The recommendations if implemented would result in significant cost savings, currently being quantified as a result of consolidation and improved efficiency. A reinvestment of these cost savings would be required to address facility expansion and program enhancement to maximize patient-centered expert care consistently across all of our remaining sites of service.

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Zhao, Jin, Huan Wang, Hongyu Guan, Kang Du, Yunyun Zhang et Nathan Congdon. « Impact of Teacher Incentive Intervention on Students’ Vision Healthcare Uptake : A Cluster-Randomized Controlled Trial ». International Journal of Environmental Research and Public Health 19, n^o 19 (5 octobre 2022) : 12727. http://dx.doi.org/10.3390/ijerph191912727.

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Less than one-third of rural Chinese children with refractive error own or wear eyeglasses. To study the effect of teacher incentives on the acceptance of vision care offered to rural students with uncorrected refractive error, we conducted a cluster-randomized controlled trial in 18 townships in one county in Shaanxi Province. Primary and junior high schools within each township were assigned to either intervention (all teachers received an incentive) or control (no teacher incentives were offered) groups. A total of 42 schools were assigned to either the intervention group (13 schools) or the control group (29 schools). Teachers in the intervention group could elect to receive high-value (sunglasses worth USD 148), moderate-value (eyeglasses worth USD 89), or cash incentives (USD 35) if ≥70% of eligible students (uncorrected visual acuity (VA) ≤ 6/12 in both eyes and corrected VA ≤ 6/9.5 in both eyes) in the teacher’s class visited a program-affiliated vision center (VC) within 60 days after their vision screening. Among 8238 students, 3401 (41.2%, of which 53.0% were girls with a mean age of 12 (SD 1.75)) met the enrollment criteria and were randomly allocated to the intervention (n = 1645, 49.0%) and control groups (n = 1579, 51.0%). Among these, 3224 (94.8%) completed the study and underwent analysis. Nearly equal numbers of students had classroom teachers selecting the high-value (n = 524, 31.9%), moderate-value (n = 582, 35.4%), and cash incentives (n = 539, 32.8%). The rate of the acceptance of offered vision care was significantly higher in the intervention group (382/1645 = 23.2%) compared to the control group (172/1579 = 10.9%, 95% confidence interval for observed difference 12.3%, p < 0.001). Teacher incentives appeared effective in improving Chinese rural school-aged children’s uptake rate of vision services provided by county hospital-based VCs.

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Elston Lafata, Jennifer Elston, Jenna Benjamin, Lori A. David, Emily Miller Ray et Hanna Kelly Sanoff. « Establishing purposeful oncology care disparities reduction strategies. » JCO Oncology Practice 19, n^o 11_suppl (novembre 2023) : 166. http://dx.doi.org/10.1200/op.2023.19.11_suppl.166.

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166 Background: Quality thought leaders have noted the oneness of care quality and equity. Yet, quality improvement (QI) often ignores equity. We implemented a holistic approach to quality specifically designed to facilitate equity. We report the components of the approach and how it is being used to address disparities in unplanned acute care events (ACEs) among chemotherapy patients. Methods: We used the Institute for Health Improvement Whole System Quality framework to integrate care equity in an established quality program. We started by stratifying oncology dashboards by race, ethnicity, and language (REAL) as well as other factors (monitoring). We developed and implemented an Umbrella Action Plan Policy that specified an accountability structure to identify and address disparities (planning) and via goal setting (planning), prioritized, developed, and executed action plans to address disparities once identified (improvement). Results: In February 2023 a system-level senior leadership committee charged with priority setting cancer care quality initiatives approved the Umbrella Action Policy. This led to REAL-stratified, quarterly performance reports being shared with senior leadership who voted for this year’s annual goals to include identification and use of rapid cycle testing to eliminate ACE disparities. The organization-level goal engendered central QI coaching resources, established local entity QI teams within each System-affiliated entity with dedicated oncology program (N=6), and formed a learning collaborative across entities. One of each local QI team chose to focus on reducing race-related, language-related, and payor-related (Medicaid) disparities. The other organizations chose otherwise (e.g., age or gender). Teams are using two approaches to identify ACE root causes among target populations: (1) a structured chart abstraction form to search for, among other things, communication breakdowns, gaps in symptom management or other supportive care, and access barriers; and (2) a semi-structured interview guide to engage patients and caregivers for input and suggestions. In September, teams will work collaboratively to identify and execute small tests of change to alleviate identified drivers contributing to ACE disparities. Data from chart abstractions and patient engagement interviews will be shared along with results from tests of change tried to date. Conclusions: Facilitating the identification of disparities via REAL stratified dashboards, leadership teams setting expectations regarding gap closure, and allocation of resources to support local QI teams has focused the quality planning, monitoring, and, to some extent, improvement activities on care equity among marginalized populations. Prescriptively focusing local organization efforts may be needed for appropriate selection of target populations when wanting to infuse REAL equity in QI programming.

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Hensel, Jennifer M., James Shaw, Noah M. Ivers, Laura Desveaux, Simone N. Vigod, Ashley Cohen, Nike Onabajo et al. « A Web-Based Mental Health Platform for Individuals Seeking Specialized Mental Health Care Services : Multicenter Pragmatic Randomized Controlled Trial ». Journal of Medical Internet Research 21, n^o 6 (4 juin 2019) : e10838. http://dx.doi.org/10.2196/10838.

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Background Web-based self-directed mental health applications are rapidly emerging to address health service gaps and unmet needs for information and support. Objective The aim of this study was to determine if a multicomponent, moderated Web-based mental health application could benefit individuals with mental health symptoms severe enough to warrant specialized mental health care. Methods A multicenter, pragmatic randomized controlled trial was conducted across several outpatient mental health programs affiliated with 3 hospital programs in Ontario, Canada. Individuals referred to or receiving treatment, aged 16 years or older, with access to the internet and an email address, and having the ability to navigate a Web-based mental health application were eligible. A total of 812 participants were randomized 2:1 to receive immediate (immediate treatment group, ITG) or delayed (delayed treatment group, DTG) access for 3 months to the Big White Wall (BWW), a multicomponent Web-based mental health intervention based in the United Kingdom and New Zealand. The primary outcome was the total score on the Recovery Assessment Scale, revised (RAS-r) which measures mental health recovery. Secondary outcomes were total scores on the Patient Health Questionnaire-9 item (PHQ-9), the Generalized Anxiety Disorder Questionnaire-7 item (GAD-7), the EuroQOL 5-dimension quality of life questionnaire (EQ-5D-5L), and the Community Integration Questionnaire. An exploratory analysis examined the association between actual BWW use (categorized into quartiles) and outcomes among study completers. Results Intervention participants achieved small, statistically significant increases in adjusted RAS-r score (4.97 points, 95% CI 2.90 to 7.05), and decreases in PHQ-9 score (−1.83 points, 95% CI −2.85 to −0.82) and GAD-7 score (−1.55 points, 95% CI −2.42 to −0.70). Follow-up was achieved for 55% (446/812) at 3 months, 48% (260/542) of ITG participants and 69% (186/270) of DTG participants. Only 58% (312/542) of ITG participants logged on more than once. Some higher BWW user groups had significantly greater improvements in PHQ-9 and GAD-7 relative to the lowest use group. Conclusions The Web-based application may be beneficial; however, many participants did not engage in an ongoing way. This has implications for patient selection and engagement as well as delivery and funding structures for similar Web-based interventions. Trial Registration ClinicalTrials.gov NCT02896894; https://clinicaltrials.gov/ct2/show/NCT02896894 (Archived by WebCite at http://www.webcitation.org/78LIpnuRO)

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Mokadem, Naglaa M. EL, Eman A. Shokr, Alyaa H. Salama, Hanaa M. Abo Shereda, Hanaa A. Radwan et Hemat Mostafa Amer. « Peer Education Intervention to Promote Drug Abuse Prevention among Secondary Schools Students ». NeuroQuantology 19, n^o 5 (10 juin 2021) : 68–78. http://dx.doi.org/10.14704/nq.2021.19.5.nq21050.

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Drug abuse is a worldwide serious health problem. Peer education is an effective method in preventing risky behaviors and educating teens about drug abuse. Aim of the current study was to evaluate the effectiveness of peer education intervention to promote drug abuse prevention among secondary schools students. Methods: a quasi-experimental research design was used. A multi-stage random sample selection of six secondary schools affiliated to the Ministry of Education and Technical Education was utilized. A convenience sample of 1200 students was selected from the 1st, 2nd and 3rd grades of the selected schools at Shebin El kom, Menoufia Governorate, Egypt. Instruments: (1) Sociodemographic data questionnaire; (2) Basic knowledge of students about drug abuse questionnaire; (3) Attitudes of the students toward drug abuse prevention assessment questionnaire and; (4) Self-efficacy of students about drug abuse prevention questionnaire. Results: the mean age of the studied students in both study and control groups were (16.14 ± 1.08 &15.96 ± 1.01) respectively. There were statistically significant differences between study and control group in the total mean score of knowledge about drug abuse post intervention (12.39 ±1.72 & 6.88 ± 1.35; P value .000) compared to pre-intervention (6.95 ± 2.14 & 6.72 ± 2.19; P 0 .535). There was a statistically significant difference between study and control group regarding students' attitudes toward drug abuse post intervention (160.98 ± 11.72 & 75.55 ± 13.35; P 0.000) compared to pre-intervention (77.53 ± 12.14 & 75.89 ± 11.19; P 0.735). Finally, there was a statistically significant difference between study and control group regarding students' self efficacy about drug abuse prevention post intervention (11.84 ± 1.92 & 8.18 ± 1.55; P 0.000) compared to pre-intervention (8.89 ± 3.14 & 7.99 ± 1.92; P 0.598). Conclusions: the findings of the current study suggest that peer education intervention has a positive effect and significantly enhances knowledge, self-efficacy and attitudes of secondary school students toward drug abuse. Recommendation: Peer education intervention as a school-based prevention programs is an appropriate model to be implemented for drug abuse prevention among school students.

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Croitoru, Ionuț Marius, Răzvan Mihai Dobrescu et Cosmin Alexandru Spiridon. « Impact of European Projects on Human Resources ». Proceedings of the International Conference on Business Excellence 18, n^o 1 (1 juin 2024) : 3007–22. http://dx.doi.org/10.2478/picbe-2024-0248.

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Abstract In the knowledge-based economy, effective public policies and programs that enhance the quality of human capital are an essential requirement for maintaining the competitiveness of the European economy on a global scale. As regional disparities remain to this day, the Structural Funds aim to promote convergence by improving the economic efficiency of the poorest states. It is normal to analyze and determine the effect that European funding has on the development of human capital in those regions. In order to emphasize the significance of European funding and the relationship between the level of support offered through the implementation of European projects and the development of human capital, we have carried out a bibliometric study of the data available in the WOS database. The 479 scientific articles were extracted using the tag "impact of European projects on human resources" by applying specific filters and keywords. The searches were distributed by year, by country, by affiliated institutions, and by the highest word density of the reviewed articles. The stages of the investigation method were based on the PRISMA Statements methodology. The conclusions of the article are a starting point for future analyzes regarding the impact of European funds on human resources, considering that the end of the second programming period of the structural funds accessed directly by Romania was 2023. Our findings show the existence of 4 separate directions of analysis and substantiation of the results.: cluster 1 contains the impact of European funding on the development of human resources; cluster 2 contains systems for distribution, prioritization and selection of potential beneficiaries; cluster 3 contains references to the specific policies of the European Union, and cluster 4 contains articles that analyze models for the allocation, management and evaluation of European funds. For the specific analysis of a certain field of research, we can have as a starting point a keyword found in the 4 clusters with the links within the clusters and between the clusters to find new topics of interest, new interdisciplinary correlations and new methods of approach.

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Zureigat, Hadil, Daniel P. Nurse, Mariah Odneck, Bridget Adcock, Asad Rauf, Heya Batah, Bianca Honnekeri et al. « Survey Study : Exploring Adoption Rates of the 2022 I.C.C and W.H.O Myeloid Neoplasm Classifications in the U.S ». Blood 142, Supplement 1 (28 novembre 2023) : 7293. http://dx.doi.org/10.1182/blood-2023-190547.

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Introduction: Standardizing the diagnosis of neoplasms is critical and can be achieved by having a clearly defined set of diagnostic guidelines. These guidelines play a vital role in guiding treatment choices and facilitating meaningful comparisons among patient populations in both intra- and inter-clinical trials. In 2022, two distinct pathologic guidelines for hematopoietic neoplasm classification were published, the International consensus classification (ICC) and the fifth edition of the World Health Organization (WHO HEM5) classification. Despite having major overlap, there are differences between the two guidelines, posing a potential source of confusion for clinicians. Methods: An anonymous online survey was deployed to assess the impact of having two separate diagnostic classifications on both clinical practice and research. The survey was carefully designed to gather valuable insights from attending physicians and fellows-in-training associated with Hematology, Medical Oncology, and Hematopathology fellowship programs at various US institutions. The survey was distributed electronically via a secure link, ensuring participant confidentiality. The link was disseminated to all program directors, program coordinators, and department chiefs/heads, requesting further distribution among their respective teams. Moreover, it was disseminated using social media platforms, including Twitter and LinkedIn. A sample size was estimated to be 140 responses from hematopathologists and 148 from other specialties, using a 95% confidence interval and 8% error margin. Results: A total of 310 responses were obtained. Of those, 228/308 (73.5%) were attendings and more than half (54%) have been in the field for over five years. A total of 239/310 (77.1%) work in a large hospital setting and 265/310 (85.5%) reported that published guidelines are important for clinical practice/management. Additionally, 246/300 (82%) agree that guidelines are important for patient selection in research studies. A total of 292/297 (98%) reported using WHO 2016 before 2022, and 68/310 (22%) reported still using it currently. Otherwise, 112/310 (36%) reported using WHO HEM5 2022 and 57/310 (18.4%) reported ICC, while 143/310 (46.1%) reported using a combination of the above. There was no association between community type (urban/suburban/rural), region (West, Southwest, Midwest, Northeast, Southeast), practice setting (Community-based, Community-based/University affiliated or University based), on choice of diagnostic guideline (p>0.05). Among respondents 131/251 (52%) reported that ICC and WHO HEM5 2022 were “somewhat” similar as opposed to similar/very similar. The most differences were reported in diagnostic criteria for MDS and AML. When asked about potential confusion resulting from having two guidelines, 45/310 (14.5%) believed it would cause confusion in clinical management, 124/310 (40%) in clinical diagnosis, 46/310 (14.8%) in trial design, and 29/310 (9.4%) in drug authorization. Among respondents, 255/309 (82.5%) reported that the presence of two distinct classifications was discussed at their institutions, and most reported that the discussion was brought in the context of making a new diagnosis. More than half 179/310 (57.7%) describe the general opinion of their colleagues as negative, while 59/310 (19%) stated that the reaction was rather indifferent. More than half 176/308 (57.1%) of pathologists reported that their institution adopted both/either depending on style/condition. Only 60% 155/258 stated that the leadership has discussed the presence of two classifications with their faculty. Of those working in an institution where it was not brought up, 54/102 (52.9%) think it should have been discussed, and a single classification should be adopted instead. Conclusions: There is significant variation in the adoption rate of diagnostic classification of hematologic disorders across the USA, both at an inter and intra-institutional level. Having two separate diagnostic guidelines poses a potential source of confusion for clinicians and researchers. Consequently, it is imperative to focus on future endeavors aimed at unifying diagnostic classifications to enhance clarity and consistency in the field.

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Wu, Xingyue, Chengcheng Fu, Hongmiao Shen, Hongying You, Yingying Zhai, Jing Wang, Zhi Yan et al. « IMWG /ECOG Frailty Score Was a Good Indicator for ASCT Candidate Selection for NDMM in China from a Hcmmd Retrospective Study ». Blood 142, Supplement 1 (28 novembre 2023) : 7061. http://dx.doi.org/10.1182/blood-2023-185763.

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Background Autologous hematopoietic stem cell transplantation (ASCT) has always been considered as the standard choice for newly diagnosed multiple myeloma (NDMM) patients less than 65 years old, or even older. At present, how to define the patients who is suitable for transplantation is still controversial in clinic in China. Rate of utility of ASCT in front line was as low as 10%. The screening of transplant patients mainly depends on the evaluation of the general condition of patients, the wishes of patients and their families, and the evaluation of organ function by physical examination. In this way, it is particularly difficult for doctors in non-transplant medical units to recommend stem cell transplantation for patients. Based on “HemaTank” Chinese multiple myeloma database(HCMMD), a retrospective study of construction of special disease cohort and prognostic model for multiple myeloma were conducted to explore the posibilities of utility of IMWG/ECOG frailty score to select transplantation candidate, and the prognostic significance of frailty score in all MM patients. Methods In this study, 322 NDMM in the first affiliated Hospital of Soochow University from August 2018 to October 2022 were analyzed retrospectively. All patients were valuated with IMWG/ECOG frailty score before each cycle of treatment, which included age, the ECOG score, and the Charlson Comorbidity Index. Patients with IMWG frailty score≥2 were defined as frail, with score <2 were unfrail. Transplant patients received 4 courses of induction of VRd regimen followed by ASCT, and 2 courses of VRD consolidation after transplantation. Non-transplant patients received 8 courses of induction with VRD regimen. Standard risk patients received lenalidomide as maintenance therapy until PD. High risk patients received V+R as maintenance treatment until PD. Results The median age of 322 patients was 58(29-79). 178(55.3%) patients were male. 170 (52.8%) patients were unfrail at diagnosis, with a mean age of 56.72±7.11. 77.8% of the unfrail patients were less than 65 years old. 152 patients were frail at diagnosis, with a mean age of 59.47±8.28. 68% of the patients were less than 65 years old. There were statistical differences in age, DS stage, ISS stage and R-ISS stage between the two groups. (P < 0.05). After induction therapy, 246 patients (76%) rescored IMWG/ECOG frailty score before ASCT. 46 patients changed from frail state at first diagnosis to nonfrail before transplantation, mainly because of the improvement of ECOG score and renal function. There is no change from a nonfrail state at the first diagnosis to a frail state when entering the ASCT program. After logistics regression analysis of IMWG/ECOG score, age, renal function and CCI, unfrailty is the best indicator of selection patients as ASCT candidate, OR=0.37, 95%CI 0.21-0.63 (P < 0.001). At the time of ASCT, there was no significant difference in the ORR of induction therapy between frail and unfrail patients. But the granulocyte and platelet reconstruction during ASCT in the frail group was slower than that in the unfrail group, P<0.0001. The transplantation-related mortality was 0. In this cohort, the PFS and OS of the NDMM patients accepted VRD+transplantation was all better than those received VRD only. Most importantly, the OS of the frail patients scored at the time of ASCT was much poorer (P<0.05) than that of the unfrail group with no significant difference in PFS between two groups. But there were no significant differences in PFS and OS of the patients who changed from frail to unfrail after induction therapy compared with those remained unfrail at diagnosis and after induction therapy. Conclusion IMWG/ECOG frailty score can be used to select ASCT candidate for NDMM patients. In the study 144 patients (84.7%) remained unfrail at diagnosis and before transplantation accepted ASCT. and 46 frail patients (30.2%) at diagnosis transferred from frail to unfrail after induction and accepted transplantation. It was suggested that the IMWG/ECOG frailty score evaluated before transplantation is more instructive for long-term overall survival. The OS of unfrail patients was better than that of frail patients even with no significant difference in PFS.

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