Littérature scientifique sur le sujet « Acyl-CoAs metabolome »
Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres
Sommaire
Consultez les listes thématiques d’articles de revues, de livres, de thèses, de rapports de conférences et d’autres sources académiques sur le sujet « Acyl-CoAs metabolome ».
À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.
Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.
Articles de revues sur le sujet "Acyl-CoAs metabolome"
Tokarska-Schlattner, Malgorzata, Nour Zeaiter, Valérie Cunin, Stéphane Attia, Cécile Meunier, Laurence Kay, Amel Achouri et al. « Multi-Method Quantification of Acetyl-Coenzyme A and Further Acyl-Coenzyme A Species in Normal and Ischemic Rat Liver ». International Journal of Molecular Sciences 24, no 19 (6 octobre 2023) : 14957. http://dx.doi.org/10.3390/ijms241914957.
Texte intégralHan, Lijuan, Ling Zhao, Yong Zhou, Chao Yang, Teng Xiong, Lin Lu, Yusheng Deng et al. « Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity ». ISME Journal 16, no 4 (8 novembre 2021) : 983–96. http://dx.doi.org/10.1038/s41396-021-01123-5.
Texte intégralIGAL, R. Ariel, Ping WANG et Rosalind A. COLEMAN. « Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid : evidence for functionally separate pools of acyl-CoA ». Biochemical Journal 324, no 2 (1 juin 1997) : 529–34. http://dx.doi.org/10.1042/bj3240529.
Texte intégralPons, Roser, et Darryl C. De Vivo. « Primary and Secondary Carnitine Deficiency Syndromes ». Journal of Child Neurology 10, no 2_suppl (novembre 1995) : 2S8–2S24. http://dx.doi.org/10.1177/0883073895010002s03.
Texte intégralYu, Wenfeng, Xiquan Liang, Regina E. Ensenauer, Jerry Vockley, Lawrence Sweetman et Horst Schulz. « Leaky β-Oxidation of atrans-Fatty Acid ». Journal of Biological Chemistry 279, no 50 (4 octobre 2004) : 52160–67. http://dx.doi.org/10.1074/jbc.m409640200.
Texte intégralVarner, Erika L., Sophie Trefely, David Bartee, Eliana von Krusenstiern, Luke Izzo, Carmen Bekeova, Roddy S. O'Connor et al. « Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues ». Open Biology 10, no 9 (septembre 2020) : 200187. http://dx.doi.org/10.1098/rsob.200187.
Texte intégralXia, Chuanwu, Zhuji Fu, Kevin P. Battaile et Jung-Ja P. Kim. « Crystal structure of human mitochondrial trifunctional protein, a fatty acid β-oxidation metabolon ». Proceedings of the National Academy of Sciences 116, no 13 (8 mars 2019) : 6069–74. http://dx.doi.org/10.1073/pnas.1816317116.
Texte intégralLone, Museer A., Andreas J. Hülsmeier, Essa M. Saied, Gergely Karsai, Christoph Arenz, Arnold von Eckardstein et Thorsten Hornemann. « Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases ». Proceedings of the National Academy of Sciences 117, no 27 (23 juin 2020) : 15591–98. http://dx.doi.org/10.1073/pnas.2002391117.
Texte intégralCarrer, Alessandro, Joshua L. D. Parris, Sophie Trefely, Ryan A. Henry, David C. Montgomery, AnnMarie Torres, John M. Viola et al. « Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels ». Journal of Biological Chemistry 292, no 8 (11 janvier 2017) : 3312–22. http://dx.doi.org/10.1074/jbc.m116.750620.
Texte intégralWu, Hao, Jingdan Liang, Lixia Gou, Qiulin Wu, Wei-Jun Liang, Xiufen Zhou, Ian J. Bruce, Zixin Deng et Zhijun Wang. « Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882 ». Applied and Environmental Microbiology 84, no 12 (13 avril 2018) : e00587-18. http://dx.doi.org/10.1128/aem.00587-18.
Texte intégralThèses sur le sujet "Acyl-CoAs metabolome"
Zeaiter, Nour. « Les effets des changements métaboliques sur le métabolome des acyl-CoAs et l'acylation d'histone épigénétique ». Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALV013.
Texte intégralAccumulating evidence suggests that metabolism can affect epigenetic post-translational modifications of histones, thus potentially linking nutrient availability or environmental conditions to gene expression and human physiopathology. However, there is still a lack of more detailed insight into this relationship. Here we study the role of short-chain (sc)-acyl-CoAs, generated in various metabolic pathways, as substrates for histone acylation. Analyzing acyl-CoAs is challenging due to their diverging (sub)cellular concentrations and physico-chemical properties. First, we applied a panel of analytical methods to establish reliable acyl-CoAs quantification, using liver ischemia as a model for inducing a metabolic shift. HPLC and MS emerged as the most suitable methods for unbiased analysis of sc-acyl-CoAs. Second, we employed HepG2 cells as a model system to explore the role of metabolic key enzymes and nutrient-induced metabolic shifts on acyl-CoA levels and histone acylation. Here and in the following, sc-acyl-CoAs were quantified by MS, and histone acylation was assessed at H4K5 and H4K8 by immunoblotting. Knockdown (KD) of enzymes involved in nucleocytosolic generation of acetyl-CoA (and potentially other acyl-CoAs) confirmed that ATP citrate lyase (ACLY) and acetyl-CoA synthetase short chain 2 (ACSS2) are the two major sources for nucleo-cytosolic acetyl-CoA. Moreover, we demonstrated that contrary to widespread believe, ACSS2 is not involved in biosynthesis of sc-acyl-CoAs other than acetyl-CoA. Further, KD of carnitine palmitoyltransferase 1A (CPT1A) did not yield clear evidence for its involvement in the export of mitochondrial sc-acyl-CoAs. Among the metabolic shifts studied, changes in acyl-CoA levels correlated with altered histone acylation only in some cases, namely octanoate fatty acid supplementation and glucose deprivation. These data suggest that substrate availability can be a determining factor for histone acylation, but that other factors can also be involved. Third, a transgenerational rat model for the effects of an environmental pollutant, endocrine disruptors (ED), revealed altered histone acylation patterns. Here we developed a HepG2 cell model that recapitulates direct ED effects on histone acylation, in particular an increased level of acetylation, together with increased acetyl-CoA levels. These data suggest HepG2 cells as a suitable model to study epigenetic ED effects mechanistically. In summary, this work established a basis to study epigenetic effects of nutrients and environmental pollutants in more detail
Knoll, Anja. « Etude du métabolisme des acides gras à très longues chaînes dans le cerveau du rat : activités enzymatiques d'élongation des acyl-CoAs, expression des gènes de la béta-oxydation peroxysomale ». Bordeaux 2, 2000. http://www.theses.fr/2000BOR28756.
Texte intégral