Littérature scientifique sur le sujet « Activation de la liaison C(sp2)-H »
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Articles de revues sur le sujet "Activation de la liaison C(sp2)-H"
Wencel-Delord, Joanna, et Françoise Colobert. « Asymmetric C(sp2)H Activation ». Chemistry - A European Journal 19, no 42 (17 septembre 2013) : 14010–17. http://dx.doi.org/10.1002/chem.201302576.
Texte intégralWencel-Delord, Joanna, et Francoise Colobert. « ChemInform Abstract : Asymmetric C(sp2)-H Activation ». ChemInform 45, no 2 (19 décembre 2013) : no. http://dx.doi.org/10.1002/chin.201402241.
Texte intégralBakthadoss, Manickam, Tadiparthi Thirupathi Reddy, Vishal Agarwal et Duddu S. Sharada. « Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination ». Chemical Communications 58, no 9 (2022) : 1406–9. http://dx.doi.org/10.1039/d1cc06097j.
Texte intégralDutta, Uttam, Sudip Maiti, Trisha Bhattacharya et Debabrata Maiti. « Arene diversification through distal C(sp2)−H functionalization ». Science 372, no 6543 (13 mai 2021) : eabd5992. http://dx.doi.org/10.1126/science.abd5992.
Texte intégralZhang, Yanghui, Bo Zhou et Ailan Lu. « Pd-Catalyzed C–H Silylation Reactions with Disilanes ». Synlett 30, no 06 (18 décembre 2018) : 685–93. http://dx.doi.org/10.1055/s-0037-1610339.
Texte intégralBritton, Luke, Jamie H. Docherty, Andrew P. Dominey et Stephen P. Thomas. « Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation ». Molecules 25, no 4 (18 février 2020) : 905. http://dx.doi.org/10.3390/molecules25040905.
Texte intégralGeng, Cuihuan, Sujuan Zhang, Chonggang Duan, Tongxiang Lu, Rongxiu Zhu et Chengbu Liu. « Theoretical investigation of gold-catalyzed oxidative Csp3–Csp2 bond formation via aromatic C–H activation ». RSC Advances 5, no 97 (2015) : 80048–56. http://dx.doi.org/10.1039/c5ra16359e.
Texte intégralSong, Liangliang, Guilong Tian, Johan Van der Eycken et Erik V. Van der Eycken. « Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)–H activation and C(sp3)–H amination ». Beilstein Journal of Organic Chemistry 15 (27 février 2019) : 571–76. http://dx.doi.org/10.3762/bjoc.15.52.
Texte intégralMoghimi, Setareh, Mohammad Mahdavi, Abbas Shafiee et Alireza Foroumadi. « Transition-Metal-Catalyzed Acyloxylation : Activation of C(sp2)-H and C(sp3)-H Bonds ». European Journal of Organic Chemistry 2016, no 20 (19 juin 2016) : 3282–99. http://dx.doi.org/10.1002/ejoc.201600138.
Texte intégralDhara, Shubhendu, Raju Singha, Atiur Ahmed, Haridas Mandal, Munmun Ghosh, Yasin Nuree et Jayanta K. Ray. « Synthesis of α, β and γ-carbolines via Pd-mediated Csp2-H/N–H activation ». RSC Adv. 4, no 85 (2014) : 45163–67. http://dx.doi.org/10.1039/c4ra08457h.
Texte intégralThèses sur le sujet "Activation de la liaison C(sp2)-H"
Massouh, Joe. « Transition metals-catalyzed C(sp2)-H bond activation for aldehyde functionalization ». Electronic Thesis or Diss., Ecole centrale de Marseille, 2022. http://www.theses.fr/2022ECDM0001.
Texte intégralThe synthesis of α-ketoacid, precursor or analogue of amino-acid, presents a center of interest. One of the synthetic pathways leading to these molecules could be the direct functionalization of aldehyde. The C(sp2)-H bond activation of aldehyde catalyzed by organometallic complexes is a powerful tool to afford various elaborated products in a relatively sustainable manner.In the first chapter of this manuscript, we presented the organometallic complexes based on different transition metals like Rh, Co, Ru, Ni, and Ir, that are able to activate selectively the C(sp2)-H bond of aldehyde. The reported procedures involve transition metals at low oxidation state favoring the oxidative addition mechanism, or at high oxidation state favoring the concerted metalation deprotonation process. This presentation allows to display the advantages and the drawbacks of each approach and highlights the novelty in each concept.In the second chapter, according to bibliography, procedures were investigated to achieve aldehyde C-H functionalization with various reagents, notably carbon dioxide. Various transition metals at low oxidation states were studied, and the reactivity of the aldehyde substrate remained restricted to the reported examples under Rh(I)-catalysis. In the case of high oxidation state transition metals, Rh(III)-catalytic complex was found efficient to mediate new pathway to imides using dioxazolones in good yields (up to 97%). Numerous parameters affecting the C-H activation of aldehyde were screened, and the mechanistic investigations were supported by labelling tests. Unfortunately, we observed that some catalytic systems, that are able to achieve aromatic C(sp2)-H bond functionalization with carbon dioxide, were not efficient to afford the carboxylation of aldehydic C(sp2)-H bond. The third chapter disclosed the experimental procedures and the characterization of the new products, notably imides
Zhao, Liqin. « Palladium-catalyzed direct arylation via sp² and sp³ C-H activation of hetero(aromatics) and hydrocarbons for C-C bond formation ». Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S038/document.
Texte intégralDuring this thesis, we were interested in the sp² and sp³ C-H bond activation catalyzed by palladium catalysts for the preparation of (hetero)aryl-aryls and biaryls. This method is considered as cost effective and environmentally attractive compared to the classical couplings such as Suzuki, Heck, or Negishi. First we described the palladium-catalyzed direct C2-arylation of benzothiophene in the absence of phosphine ligand with high selectivity. We also demonstrated that it is possible to active both C2 and C5 C-H bonds for access to 2,5-diarylated compounds in one step, and also to non-symmetrically substituted 2,5-diarylpyrroles via sequential C2 arylation followed by C5 arylation. We also studied the reactivity of polychlorobenzenes via palladium-catalyzed C-H activation. We finally examined the palladium-catalysed selective sp² and sp³ C-H bond activation of guaiazulene. The selectivity depends on the solvent and base: sp² C2-arylation (KOAc in ethylbenzene), sp² C3-arylation (KOAc in DMAc) and sp³ C4-Me arylation (CsOAc/K₂CO₃ in DMAc). Through this method, a challenging sp³ C-H bond was activated
Gonnard, Laurine. « Réactions métallo-catalysées : synthèse d'hétérocycles azotés saturés fonctionnalisés ». Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066438/document.
Texte intégralIn order to facilitate the total synthesis of active molecules used in pharmaceutical or agrochemical industries, chemists try constantly to develop new, general, practical and sustainable methods. In 2014, a study revealed that piperidine was the most frequently present aza-heterocycle in medicines approved by the Food and Drug Administration (FDA). In this context, three different methods were developed during this Ph.D in order to synthesize functionalized piperidines. A wide variety of substituted piperidines was first efficiently obtained by a cobalt catalyzed cross-coupling reaction between 4- and 3-halogenopiperidines and Grignard reagents. Cobalt has appeared as a good alternative to the expensive palladium salts or the toxic nickel salts. Moreover, it can prevent side reactions such as dehydrohalogenation or β-H elimination. Next, 2-dienylpiperidines, present in a myriad of alkaloids, were prepared by iron catalyzed cyclization from diallylic amino-alcools. Finally, new conditions for the ruthenium catalyzed C(sp3)‒H monoarylation of piperidines were developed. The influence of the electronic and steric properties of the directing group attached to the nitrogen of the piperidine was fully studied. These methods were then applied to the synthesis of other azacycles
Sofack-Kreutzer, Julien. « Synthèses de carbocycles et d'hétérocycles à cinq chaînons par activation de liaisons c(sp3)-h non activées ». Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00744243.
Texte intégralRenaudat, Alice. « Fonctionnalisation de liaisons C(sp3)-H non activées catalysées par le palladium ». Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00704011.
Texte intégralHitce, Julien. « Fonctionnalisation intramoléculaire de liaisons C(sp3)-H catalysée par le palladium : études méthodologiques et applications en synthèse organique ». Paris 11, 2007. http://www.theses.fr/2007PA112192.
Texte intégralA palladium-catalyzed intramolecular C(sp3)-H functionalization reaction of benzylic alkyl groups was studied. Both methodological and synthetic aspects were investigated. Thus, in order to determine the scope and the limitations of this new methodology and to emphasize its synthetic value, the reactivity of a variety of substrates was studied using a specifically designed catalyst. This transformation afforded either olefins adjacent to a quaternary carbon atom by dehydrogenation or polycycles by intramolecular arylation of C(sp3)-H bonds. The dehydrogenation methodology was illustrated in the synthesis of the antihypertensive drug verapamil. The mechanism of the new reaction involves 5- and 6-membered palladacycles: the C-H bond cleavage is an intramolecular process. Moreover, the catalytically active species is most probably a molecular complex though the formation of palladium nanoparticles was evidenced. Finally, selective palladium-catalyzed cascade reactions were designed. They combined C(sp3)-H functionalization, Heck cyclization, Heck arylation or olefin hydrogenation to afford valuable 4- and 5-membered carbocycles
Quint, Valentin. « Formation de liaison C-P par fonctionnalisation de liaison C-H sans métal de transition : aspects snthétiques et mécanistiques ». Thesis, Normandie, 2017. http://www.theses.fr/2017NORMC219/document.
Texte intégralThis thesis describes the successful development of three modes of activation for the formation of Carbon–Phosphorus bonds under mild conditions and without the use of transition metals.First, a regioselective phosphorylation of pyridines has been developed via a sequential process consisting of the activation of the pyridine with a Lewis acid (BF3) followed by oxidative aromatization mediated by chloranil. The characterization of the Meisenheimer complex enabled to confirm the proposed reaction mechanism. Next, we developed a straightforward approach for the synthesis of benzo[b]phospholes from the reaction of secondary phosphine oxides and alkynes in the presence of an organic oxidant and eosin Y as a catalyst. Apart from the broad scope of this reaction, extensive mechanistic investigations, including EPR, NMR, steady state photolysis permitted the elucidation of the mechanism of this photoreaction. It has been suggested that the oxidant and the photocatalyst come together to form a ground state charge transfer complex that is the driving force of the photocatalyzed process. Finally, we developed a metal-free photoinduced approach for the phosphorylation of anilines and related structures. The reaction proceeded through the formation of an electron donor acceptor complexes between anilines derivatives (electron donors) and N–ethoxypyridinium (electron acceptor). Scope and limitations of this process are discussed along with detailed mechanistic studies
Guyonnet, Mathieu. « Synthèse totale d’alcaloïdes de type dibenzopyrrocoline par arylation C(sp3)-H intramoléculaire ». Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10143.
Texte intégralThe direct functionalization of unactivated C-H bonds represents an atom- and stepeconomical alternative to more traditional synthetic methods based on functional group interconversion. Transition-metal catalysis has recently emerged as a powerful tool to functionalize otherwise unreactive C-H bonds. Whereas a lot of methodological studies have been developed in the past decade, few applications of these methodologies in multi-step or total synthesis have been reported in the literature. In this context, we envisioned the total synthesis of dibenzopyrrocoline alkaloids, a family of structurally original natural products, by using intramolecular C(sp3)-H arylation as a key step. This work led us to first develop a N-arylation / bromination / intramolecular C(sp3)-H arylation sequence which allowed us to access diverse fused tricyclic indolines. We next investigated the application of this strategy to the synthesis of the dibenzopyrrocoline motif. The difficulty to access the C(sp3)-H arylation precursor required an exploration of different synthetic pathways, which proved to be potentially promising. Finally the different performed methodological studies showed the feasibility of the intramolecular C(sp3)-H arylation of tertiary anilines, which was never described in the literature
Obenhuber, Andreas H. [Verfasser]. « Investigation into the chelate assisted activation of non-strained C(sp2)-C(sp2) single bonds using group 8, 9 and 10 transition metal complexes / Andreas H. Obenhuber ». München : Verlag Dr. Hut, 2011. http://d-nb.info/1011441535/34.
Texte intégralLEBRETON, HAQUETTE CAROLE. « Activation de la liaison c-h des alcanes par des complexes du rhodium (i) ». Paris 6, 1999. http://www.theses.fr/1999PA066614.
Texte intégralChapitres de livres sur le sujet "Activation de la liaison C(sp2)-H"
« Intramolecular Coupling via C(sp2)—H Activation ». Dans Cross Coupling and Heck-Type Reactions 3, sous la direction de Larhed et Odell. Stuttgart : Georg Thieme Verlag, 2013. http://dx.doi.org/10.1055/sos-sd-209-00374.
Texte intégralBanerjee, S., et L. Ilies. « 2.8 Iron-Catalyzed C—H Functionalization ». Dans Base-Metal Catalysis 2. Stuttgart : Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/sos-sd-239-00143.
Texte intégral« 2.6 C—H Functionalization Catalyzed by Low-Valent Cobalt ». Dans Base-Metal Catalysis 2. Stuttgart : Georg Thieme Verlag KG, 2023. http://dx.doi.org/10.1055/sos-sd-239-00042.
Texte intégralTaber, Douglass. « C-H Functionalization to Form C-O, C-N, and C-C Bonds ». Dans Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0015.
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