Thèses sur le sujet « Abdomina Aortic Aneurysm »
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Rossaak, Jeremy Ian, et n/a. « The genetics of abdominal aortic aneurysms ». University of Otago. Dunedin School of Medicine, 2004. http://adt.otago.ac.nz./public/adt-NZDU20070502.143818.
Texte intégralMello, Flávia Moerbeck Casadei de [UNESP]. « Aneurisma da aorta abdominal infra-renal : avaliação ultra-sonográfica em homens acima de 50 anos ». Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/87358.
Texte intégralCom o objetivo de avaliar a ocorrência de aneurisma da aorta abdominal infra-renal (AAAIR), estudou-se uma amostra da população masculina do Município de Marília, com idade igual ou acima de 50 anos, no período de 2000 a 2002. Foram avaliados 240 homens por meio da ultrasonografia abdominal (USAb), com média de idade de 65,1 anos (±9,8 anos). A aorta abdominal foi medida no sentido ânteroposterior (AP) e látero-lateral (LL) aproximadamente a 2cm abaixo da artéria mesentérica superior (AMS) e 2cm acima de sua bifurcação. O critério utilizado para considerar aneurisma foi o maior diâmetro encontrado igual ou maior que 3,1cm. Também por questionário, foram avaliados os fatores de risco (tabagismo, sedentarismo, alimentação) e as doenças associadas (HAS, DPOC, IM, DM, AOP ou hiperlipidemia). Nos 240 homens, foram encontrados 11 aneurismas, sendo, portanto, a freqüência de 4,6%. Desses 11 aneurismas, 8 mediam entre 3,1 e 4cm (72,7%) e 3, entre 4,1 e 5cm (27,3%). O maior diâmetro da aorta aneurismática foi de 5 cm (sentido AP a 2cm abaixo da AMS). Foi encontrada uma associação significativa entre aneurisma e AOP e DM, não ocorrendo o mesmo com os demais fatores de risco ou outras doenças associadas. A freqüência de aneurisma encontrada em nossa amostra não foi diferente da referida nos estudos populacionais publicados na literatura, o que mostra a importância da doença em nosso meio, e os indivíduos com AOP e DM têm risco maior de desenvolver a doença.
In order to evaluate the occurrence of Infra-Renal Abdominal Aortic Aneurysm (AAAIR), a sample of the male population in the city of Marília aged 50 years or older was studied from 2000 to 2002. A group of 240 men with mean age of 65,1 years (±9,8 years) was evaluated through abdominal ultra-sonography examination. The abdominal aorta was measured in the anteroposterior (AP) and in the latero-lateral directions (LL) approximately 2cm below the superior mesenteric artery and 2cm above its bifurcation. The largest diameter equal or larger than 3.1cm found was the criterion used for aneurysm. Risk factors such as smoking, eating, and exercise habits and associated diseases (systemic arterial hypertension, chronic obstructive pulmonary disease, myocardial infarction, diabetes mellitus, occlusive peripheral arterial disease, or hyperlipidemia) were also evaluated through questionnaires. Eleven aneurysms were found in the 240 men, which meant a frequency of 4,6%. Out of these 11 aneurysms, 8 measured from 3.1 to 4cm (72,7%) and 3 measured from 4.1 to 5cm (27,3%). The largest diameter of the aneurysmatic aorta was 5cm (AP direction approximately 2cm of the superior mesenteric artery). A significant association between aneurysm and peripheral vascular disease and diabetes mellitus was found. The same did not occur with the other risk factors or other associated diseases. The frequency of aneurysm found in our sample was not different from the frequency mentioned in population studies published in the literature, which shows the importance of the disease in our environment and that patients with peripheral vascular disease and diabetes mellitus have a higher risk to develop the disease.
Mello, Flávia Moerbeck Casadei de. « Aneurisma da aorta abdominal infra-renal : avaliação ultra-sonográfica em homens acima de 50 anos / ». Botucatu : [s.n.], 2003. http://hdl.handle.net/11449/87358.
Texte intégralResumo: Com o objetivo de avaliar a ocorrência de aneurisma da aorta abdominal infra-renal (AAAIR), estudou-se uma amostra da população masculina do Município de Marília, com idade igual ou acima de 50 anos, no período de 2000 a 2002. Foram avaliados 240 homens por meio da ultrasonografia abdominal (USAb), com média de idade de 65,1 anos (±9,8 anos). A aorta abdominal foi medida no sentido ânteroposterior (AP) e látero-lateral (LL) aproximadamente a 2cm abaixo da artéria mesentérica superior (AMS) e 2cm acima de sua bifurcação. O critério utilizado para considerar aneurisma foi o maior diâmetro encontrado igual ou maior que 3,1cm. Também por questionário, foram avaliados os fatores de risco (tabagismo, sedentarismo, alimentação) e as doenças associadas (HAS, DPOC, IM, DM, AOP ou hiperlipidemia). Nos 240 homens, foram encontrados 11 aneurismas, sendo, portanto, a freqüência de 4,6%. Desses 11 aneurismas, 8 mediam entre 3,1 e 4cm (72,7%) e 3, entre 4,1 e 5cm (27,3%). O maior diâmetro da aorta aneurismática foi de 5 cm (sentido AP a 2cm abaixo da AMS). Foi encontrada uma associação significativa entre aneurisma e AOP e DM, não ocorrendo o mesmo com os demais fatores de risco ou outras doenças associadas. A freqüência de aneurisma encontrada em nossa amostra não foi diferente da referida nos estudos populacionais publicados na literatura, o que mostra a importância da doença em nosso meio, e os indivíduos com AOP e DM têm risco maior de desenvolver a doença.
Abstract: In order to evaluate the occurrence of Infra-Renal Abdominal Aortic Aneurysm (AAAIR), a sample of the male population in the city of Marília aged 50 years or older was studied from 2000 to 2002. A group of 240 men with mean age of 65,1 years (±9,8 years) was evaluated through abdominal ultra-sonography examination. The abdominal aorta was measured in the anteroposterior (AP) and in the latero-lateral directions (LL) approximately 2cm below the superior mesenteric artery and 2cm above its bifurcation. The largest diameter equal or larger than 3.1cm found was the criterion used for aneurysm. Risk factors such as smoking, eating, and exercise habits and associated diseases (systemic arterial hypertension, chronic obstructive pulmonary disease, myocardial infarction, diabetes mellitus, occlusive peripheral arterial disease, or hyperlipidemia) were also evaluated through questionnaires. Eleven aneurysms were found in the 240 men, which meant a frequency of 4,6%. Out of these 11 aneurysms, 8 measured from 3.1 to 4cm (72,7%) and 3 measured from 4.1 to 5cm (27,3%). The largest diameter of the aneurysmatic aorta was 5cm (AP direction approximately 2cm of the superior mesenteric artery). A significant association between aneurysm and peripheral vascular disease and diabetes mellitus was found. The same did not occur with the other risk factors or other associated diseases. The frequency of aneurysm found in our sample was not different from the frequency mentioned in population studies published in the literature, which shows the importance of the disease in our environment and that patients with peripheral vascular disease and diabetes mellitus have a higher risk to develop the disease.
Mestre
Malina, Martin. « Endovascular repair of abdominal aortic aneurysms aspects on a novel technique / ». Lund : Dept. of Vascular and Renal Diseases, Lund University, Malmö University Hospital, 1998. http://books.google.com/books?id=hWBsAAAAMAAJ.
Texte intégralTenório, Emanuel Júnio Ramos. « Expressão dos níveis plasmáticos dos miRNA-191 e miRNA-455-3P em pacientes com aneurisma de aorta abdominal e suas relações com a evolução clínica após tratamento endovascular ». Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-10042018-142246/.
Texte intégralBackground: Abdominal aortic aneurysm (AAA) is an important cause of morbidity and mortality in the elderly population. Endovascular treatment is associated with lower morbidity and mortality than conventional treatment, however, it requires a rigorous follow-up with contrast imaging tests to confirm the aneurysmal sac exclusion. Considering that the formation of an aneurysm is a complex multifactorial process, involving the destructive remodeling of the connective tissue throughout the affected segment of the aortic wall and that this process involves a chronic local inflammation, a decrease in the number of smooth muscle cells of the media tunic, and fragmentation of the extracellular matrix of the aorta and although an aberrant expression profile of miRNAs has been associated with human diseases, including cardiovascular dysfunction, it was proposed to carry out this study involving this whole process. The main objective was to quantify and evaluate miRNA expression response to endovascular correction of abdominal aortic aneurysm based on serum dosages at the six-month follow-up. Population and Method: We recruited 30 consecutive patients with AAA without other associated inflammatory diseases from the Ambulatory of Vascular and Endovascular Surgery of the HCFMRPUSP with indication of endovascular treatment. The miRNA-191 and miRNA-455-3p were selected for study and serum dosages. The differential expression of the miRNAs was performed by the real-time PCR method, after extraction of RNA from the whole blood samples at two moments, preoperatively and after 6 months of follow-up. In addition, bioinformatics tools were used to determine pathophysiological pathways related to AAA. Demographic profile, clinical follow-up and imaging examinations with angiotomography performed in the preoperative period and after 6 months were collected. Results: Hyperexpression of miR-191 and miR-455-3p in whole blood of AAA patients was observed. The endovascular treatment of patients with AAA resulted in a significant decrease in the expression of the miRNAS studied, indicating that the exclusion of the aneurysmal sac altered their expression. In addition, the expression of miR-191 and miR-455-3p showed no correlation with the diameter of the aneurysm and analysis of the influence of the various types of devices used for the endovascular treatment of AAA did not show significant differences in the expression of miR-191 And miR-455-3p. Conclusions: The hyperexpression of miR- 191 and miR-455-3p with its significant reduction after endovascular treatment may suggest the use of these molecules as potential biomarkers in the follow-up of these patients. New studies with a greater number of cases should be performed with the objective of validating the data obtained including patients with possible endoleaks.
Svensjö, Sverker. « Screening for Abdominal Aortic Aneurysm ». Doctoral thesis, Uppsala universitet, Kärlkirurgi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198677.
Texte intégralLowe, Christopher. « Three-dimensional ultrasound in the management of abdominal aortic aneurysm ». Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/threedimensional-ultrasound-in-themanagement-of-abdominal-aorticaneurysm(b8950db7-847b-4d11-a6a5-2a06b3bb66d0).html.
Texte intégralChinien, Ganessen. « Molecular genetics of abdominal aortic aneurysm ». Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/molecular-genetics-of-abdominal-aortic-aneurysm(e269485a-e71a-41a7-9a8e-ae40eb968dd4).html.
Texte intégralDjavani, Gidlund Khatereh. « Intra-abdominal Hypertension and Colonic Hypoperfusion after Abdominal Aortic Aneurysm Repair ». Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149241.
Texte intégralAlves, Lais Missae Murakami Domingues Estraiotto. « Estudo da expressão sérica do microRNA-1281, proteína C reativa e avaliação da função renal em indivíduos com aneurisma de aorta abdominal antes e após tratamento endovascular ». Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-28052018-160605/.
Texte intégralIntroduction: Abdominal aortic aneurysm (AAA) is a prevalent and silent disease. Currently, the endovascular approach has been widely used and is the main technique due to the innumerable advantages. However, it has a higher rate of reintervention and requires periodic follow-up with tomography over the years, which increases its costs and has implications such as altered renal function besides the accumulation of radiation. Such conditions justify the search for possible biomarkers that may perhaps replace CT. Objectives: In this study, we sought to correlate the microRNA-1281, Creactive protein (CRP) and the renal function evaluation of individuals with AAA with their evolution after endovascular treatment. Patients and methods: We selected 30 consecutive patients from the Ambulatory of Vascular and Endovascular Surgery of the HCFMRP-USP, in the period from January of 2104 until November of 2015, with abdominal aortic aneurysm and with indication for endovascular treatment. Serum dosages were made preoperatively and 6 months after the intervention Results: There was a hyperexpression of the micro-RNA -1281 in patients with aneurysm and a significant reduction of their serum levels after endovascular correction. Expression of miRNA-1281 showed a positive correlation with creatinine clearence. There was also a positive correlation of CRP with the presence of the aneurysm, and with its diameter, and there was no significant alteration of renal function measured through serum urea, creatinine and indirect clearance calculations. Conclusion: The study showed that 1281 miRNAs may prove to be a potential biomarker for eventual follow-up of patients undergoing AAA endovascular repair. New studies are needed to validate and complement these findings.
Chamberlain, Ciara M. « Granzyme B in abdominal aortic aneurysm and aortic dissection ». Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5584.
Texte intégralGopalakrishnan, Shyam Sunder. « Dynamics and Stability of Flow through Abdominal Aortic Aneurysms ». Doctoral thesis, Université de Lyon 1, Ecole Centrale de Lyon, Lyon, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/245358.
Texte intégralCarvalho, Adriana Camargo. « Niveis plasmaticos de vasopressina em cirugia de correção de aneurisma de aorta abdominal ». [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312004.
Texte intégralDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-13T22:15:18Z (GMT). No. of bitstreams: 1 Carvalho_AdrianaCamargo_M.pdf: 1640507 bytes, checksum: d217bd19f4b6097e48dac1bb2f824e35 (MD5) Previous issue date: 2009
Resumo: Objetivos: Avaliar os níveis plasmáticos de vasopressina (AVP) em pacientes submetidos à correção cirúrgica não-complicada de aneurisma de aorta abdominal (AAA). Desenho: Estudo prospectivo, descritivo, observacional. Intervenções: Nenhuma. Local: Hospital de Clínicas da Unicamp. Métodos: A AVP plasmática foi mensurada por radio-imuno-ensaio em 22 pacientes não-consecutivos submetidos à correção cirúrgica convencional de AAA infra-renal, sob anestesia combinada (geral e epidural) nos seguintes tempos: pré-operatório (T0); 2h (T1) e 6h (T2) após o término da cirurgia; e nas manhãs do 1º (T3), 2º (T4) e 3º (T5) dia pós-operatório (PO). Algumas variáveis clínicas e laboratoriais de interesse foram registradas concomitantemente. Resultados: A idade média dos pacientes foi de 68,2±10,2 anos (variando de 49-82 anos), sendo 17 homens e 5 mulheres. Os níveis plasmáticos de AVP (média±DP pg/mL) estavam baixos e dentro da faixa de normalidade em T0 (1,4±0,7; controle), aumentando significativamente em T1 (62,6±62,9; p<0,001) e T2 (31,5±49,7; p<0,001), com uma queda exponencial a seguir, retornando aos níveis basais em T5 (2,1±3,8; p = NS). Correlações positivas e estatisticamente significativas foram encontradas entre a AVP e a glicemia, lactatemia e leucócitos sangüíneos, mas não com a pressão arterial sistêmica ou osmolaridade plasmática no PO. Conclusões: O padrão de aumento da AVP plasmática, com picos nas primeiras horas de PO nestes pacientes, sugere que esta resposta está diretamente relacionada ao trauma cirúrgico, mas não às alterações hemodinâmicas e da osmolaridade plasmática. A fisiopatologia deste padrão de resposta ao estresse é ainda obscuro, e merece investigações adicionais em procedimentos cirúrgicos gerais
Abstract: Objectives: To evaluate plasma vasopressin (AVP) levels in patients undergoing uncomplicated conventional abdominal aortic aneurysm (AAA) repair. Design: Prospective, descriptive, observational study. Interventions: None. Setting: A tertiary academic hospital at Campinas, Sao Paulo, Brazil. Methods: Plasma AVP concentrations were measured by radioimmunoassay in 22 nonconsecutive adult patients undergoing infra-renal AAA repair under combined general and epidural anesthesia at the following moments: pre-operative (T0); 2h (T1) and 6h (T2) after surgical procedure; and by the morning at the 1st (T3), 2nd (T4) and 3rd (T5) postoperative days. Some clinical and laboratory variables were concomitantly recorded. Results: Patients mean age was 68.2±10.2 years (ranging 49-82 years), with 17 males and 05 females. AVP plasma levels (mean±SD pg/mL) were low and within the normal range at T0 (1.4±0.7; control), showing a significant increase at T1 (62.6±62.9; p<0.001) and at T2 (31.5±49.7; p<0.001), with a marked progressive fall in the subsequent days, returning to basal levels at T5 (2.1±3.8; p = NS). Positive and statistically significant correlations were found between AVP levels and glycemia, lactatemia and white blood cells counts, but not with systemic arterial pressure or plasma osmolarity during postoperative period. Conclusions: The pattern of plasma AVP increasing, peaking during the 1st postoperative hours, suggests that this response is directly related to the surgical trauma, but not to hemodynamic and/or plasmatic osmolarity derangements. The pathophysiology of this pattern of stress response is still unclear, and deserves further investigation in general surgical procedures
Mestrado
Pesquisa Experimental
Mestre em Cirurgia
Boyle, Jonathan Robert. « New perspectives in abdominal aortic aneurysm management ». Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29606.
Texte intégralChoke, Tieng Chek. « Molecular mechanisms of abdominal aortic aneurysm rupture ». Thesis, St George's, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511897.
Texte intégralWatton, Paul N. « Mathematical modelling of the abdominal aortic aneurysm ». Thesis, University of Leeds, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411948.
Texte intégralHolmström, Ami. « Abdominal Aortic Aneurysm Screening : an Ethical Discussion ». Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72994.
Texte intégralAbbas, Abeera. « Multimodality imaging of the abdominal aortic aneurysm ». Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/multimodality-imaging-of-the-nabdominal-aortic-aneurysm(fcdd75c2-eb72-4623-9529-515004d32d8d).html.
Texte intégralNorrgård, Örjan. « Familial occurrence of abdominal aortic aneurysms ». Doctoral thesis, Umeå universitet, Kirurgi, 1985. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100555.
Texte intégralS. 1-42: sammanfattning, s. 43-103: 5 uppsatser
digitalisering@umu
Maroney, Roy Thomas. « Missed opportunities for the detection of abdominal aortic aneurysms : a retrospective study of eighteen patients presenting with a ruptured or acute symptomatic abdominal aortic aneurysm ». Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/25566.
Texte intégralHua, Fang. « Role of angiotensin II and inflammatory cells in the development of human abdominal aortic aneurysm / ». [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18409.pdf.
Texte intégralKrenzien, Felix, Ivan Matia, Georg Wiltberger, Hans-Michael Hau, Moritz Schmelzle, Sven Jonas, Udo X. Kaisers et Peter T. Fellmer. « Early prediction of survival after open surgical repair of ruptured abdominal aortic aneurysms ». Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-156960.
Texte intégralBailey, Marc Aaron. « Store operated calcium entry in abdominal aortic aneurysm ». Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13678/.
Texte intégralTambyraja, Andrew Laksman. « Prediction of outcome after abdominal aortic aneurysm rupture ». Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/29391.
Texte intégralTegler, Gustaf. « Abdominal Aortic Aneurysm : Molecular Imaging Studies of Pathophysiology ». Doctoral thesis, Uppsala universitet, Kärlkirurgi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194663.
Texte intégralOlofsson, Anna. « Capturing circulating microRNAs in abdominal aortic aneurysm disease ». Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296450.
Texte intégralPotseluev, V., et M. Kora. « Anesthesia in endovascular abdominal aortic aneurysm (AAA) repair ». Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/58598.
Texte intégralMani, Kevin. « Abdominal aortic aneurysm epidemiological and health economic aspects / ». Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110810.
Texte intégralMascoli, Chiara <1983>. « Abdominal aortic aneurysm treatment in Emilia Romagna region ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amsdottorato.unibo.it/9291/1/mascoli-chiara-tesi.pdf.
Texte intégralNordon, Ian Michael. « Mining the proteome of abdominal aortic aneurysms ». Thesis, St George's, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546777.
Texte intégralForester, Nerys Dawn. « Mechanisms of inflammation in abdominal aortic aneurysms ». Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417894.
Texte intégralNorwood, Michael Geoffrey Austin. « Inflammatory responses in abdominal aortic aneurism repair ». Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29473.
Texte intégralMonsur, Kazi. « Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rupture / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-558-5/.
Texte intégralBrekken, Reidar. « Ultrasound-based Estimation of Strain in Abdominal Aortic Aneurysm ». Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-19999.
Texte intégralGrytsan, Andrii. « Abdominal aortic aneurysm inception and evolution - A computational model ». Doctoral thesis, KTH, Biomekanik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-197289.
Texte intégralBukaortaaneurysm (AAA) kännetecknas av en utbuktning hos aortaväggen i buken. Tillväxt av en AAA är oftast asymtomatisk, men en sådan utbuktning kan plö̈tsligt brista, vilket har hög dödlighet. Tyvärr finns det inga mediciner som kan förhindra AAA från att expandera eller brista. Patienter med upptä̈ckt AAA hålls därför under uppsikt tills operationskrav är uppnådda, såsom maximal AAA-diameter på 55 mm eller expansionstakt på 1 cm/år. Modeller för AAA-tillväxt kan bidra till att öka förståelsen för sjukdomsförloppet och till att förbättra beslutsunderlaget på en patientspecifik basis. AAA modeller för tillväxt och strukturförändring (G&R) är ganska komplicerade och innan man tar sig an denna utmaning krävs de god klinisk validering. I Artikel A har en befintlig tjockväggig modell för tillväxt av ett skikt av en AAA-skiva utö̈kats till en två-skiktsmodell. Denna modell återspeglar bättre den skiktade strukturen hos kärlväggen. Genom en parameterstudie undersö̈ktes påverkan av mekaniska egenskaper och G&R-parametrar hos en sådan modell för AAA-tillväxt. I Artikel B utvidgades modellen från Artikel A till en organnivå-modell för AAA-tillväxt. Vidare inkorporerades modellen i ett “Fluid–Solid–Growth” (FSG) ramverk. En patientspecifik geometri hos bukaortan användes för att illustrera möjligheterna med modellen. I Artikel C undersöktes utvecklingen av patientspecifika biomekaniska egenskaper hos AAA. Fyra patienter som skannats fem till åtta gånger med “Computed Tomography-Angiography” (CT-A) vid olika tillfällen analyserades. Flera icke triviala statistiska samband konstaterades mellan de analyserade parametrarna. I Artikel D undersöktes effekten av olika tillväxt-kinematik för AAA tillväxt. En modell med transversellt-isotrop-i-tjockleken-tillväxt var den bäst lämpade för AAA tillväxt, medans antagandet om fullt-isotrop-tillväxt och transversellt-isotrop-i-planet-tillväxt producerade orimliga resultat. Dessutom gav modellering av vävnadsvolymsförändring ett förbättrat väggtjockleks resultat men en fortsatt överskattning av väggförtunningen under AAA-expansionen.
QC 20161201
Milne, Alan Anderson. « Coagulopathy and haemostasis in surgery for abdominal aortic aneurysm ». Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/21422.
Texte intégralGrytsan, Andrii. « Computational model of abdominal aortic aneurysm inception and evolution ». Licentiate thesis, KTH, Biomekanik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-142649.
Texte intégralQC 20140311
Ashton, John Hardy. « Polymeric Endo-Aortic Paving (PEAP) : Initial Development of a Novel Treatment for Abdominal Aortic Aneurysms ». Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/204293.
Texte intégralSolanich, Valldaura Teresa. « Síndrome compartimental abdominal en aneurismas de aorta abdominal rotos ». Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/665385.
Texte intégralIntroduction: Ruptured abdominal aortic aneurysms (RAAA) carry a high mortality. Patients who survive surgery have mortality rates of 32 to 80%1-4). Multi-organ failure during the immediate postoperative period is a very common cause of death. Abdominal compartment syndrome (ACS) is present in 30-53% of cases and represents a frequent cause of multi-organ failure with both endovascular and open inter-ventions, which accounts for 70% of deaths (3). ACS is an independent predictor of mortality in RAAA and its prevention, detection and treatment with decompressive laparotomy can increase survival. The aim of the present study was to analyse 30-day survival of patients undergoing RAAA repair, the presence of risk factors for ACS and RAAA and the results obtained with delayed abdominal closure. Material and methods: A retrospective observational study was designed, with the inclusion of patients undergoing RAAA repair between 2002 and 2016 in the Angiology and Vascular Surgery service, at the Hospital Uni-versitari Parc Taulí. RAAA was defined as the extravasation of blood or haematoma outside the wall of the abdominal aortic aneurysm (AAA) in computed tomography (CT) angiography and/or evidence of haematoma outside the AAA during the surgery. The presence of ACS was established according to the parameters established by the WSACS or when primary abdominal closure could not be performed at the discretion of the vascular surgeon. Demographic variables, type of surgery, delayed abdominal closure, pre-, intra- and postoperative ACS risk factors and 30-day survival were collected. Results: A total of 61 patients were included out 85 eligible: 39 open and 22 endovascular surgeries.Patient not submitted to repair were excluded. Overall intra- and postoperative mortality was 54% (66.7% with open surgery and 31.8% with endovascular surgery (p=0.009)). The postoperative results of 43 patients who survived surgery were analysed: 21 (48.8%) with open surgery and 22 (51.2%) with endovascular surgery. Overall 30-day postoperative survival was 67.4% (61.9% with open surgery and 72.7 with endovascular surgery). The most frequent risk factors for abdominal compartment syndrome were: perfusion >5 litres, coag-ulopathy, transfusion > 6 units of packed red blood cells and metabolic acidosis. In the open surgery group: 12 presented ACS, 4 of which died, and 4 of the 9 patients who did not present ACS died (p=0.604). In the endovascular surgery group, 6 patients presented ACS, 4 of which died, and 3 of the 6 patients who did not present ACS died (p=0.032). Of the patients who underwent OS, the abdomen was left open in 9 cases (42.86%), and primary abdominal closure was performed in 12. Delayed abdominal closure increased survival (88.9% vs. 41.7%). Six patients in the endovascular group had decompressive laparotomy during the same sur-gical procedure. Decompressive laparotomy did not increase survival in the endovascular surgery group (42.9% vs. 87.5%). Conclusions: Abdominal compartment syndrome did not increase mortality in the open surgery group. Abdominal compartment syndrome increased mortality in the endovascular surgery group. Intraoperative mortality of RAAA was higher in the open surgery group. We did not detect differences in postoperative mortality of RAAA according to the type of surgery. The risk factors for abdominal compartment syndrome were: perfusion >5 litres, coagulopathy, trans-fusion >6 units of packed red blood cells and metabolic acidosis. Primary decompressive laparotomy increased survival in the open surgery group, but not in the endovascular surgery group.
Nasim, Akhtar. « Evaluation of endovascular repair of abdominal aortic aneurysms ». Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29600.
Texte intégralMaiellaro, Kathryn Adele. « The role of oxidative stress in abdominal aortic aneurysm development : molecular and mechanical effects in the origins of aneurysmal disease ». Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24708.
Texte intégralCommittee Chair: W. Robert Taylor; Committee Member: John Oshinski; Committee Member: Kathy Griendling; Committee Member: Raymond P. Vito; Committee Member: Rudolph L. Gleason.
Sun, Zhonghua. « CT virtual intravascular endoscopy in aortic stent grafting ». Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248607.
Texte intégralQueiroz, Andre Brito. « Análise biomecânica e histológica do colo do aneurisma da aorta abdominal infrarrenal : estudo em necrópsia ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-22012016-083039/.
Texte intégralINTRODUCTION: The neck of the infrarenal abdominal aortic aneurysm is the principal site of interaction between the aortic wall and the devices used in the repair of these aneurysms, by open or endovascular technique. Postoperative aneurysm neck dilation leading to aneurysm exclusion failures demonstrates the importance of a reliable neck for the long-term efficient repair. OBJECTIVE: To access the biomechanical and histological properties of the infrarenal aortic aneurysm neck, comparing the results with the properties of the suprarenal aorta and the anterior wall of the aneurysm. METHODS: Sixteen infrarenal abdominal aortic aneurysms found in necropsies were removed and dissected in laboratory. The original anatomy of the aneurysms was restored with the aid of a compliant balloon inserted in the specimens lumen and aneurysms with a neck shorter than 10 mm were excluded. Similar transverse fragments from the anterior aneurysm wall, aneurysm neck, and suprarenal aorta were obtained with the aid of a cutting device. Uniaxial destructive tensile tests were performed to obtain the following biomechanical properties: tension, stress, strain energy and strain at the moment of fragment failure, and the thickness of the fragments. Histological analysis was performed with the quantification of collagen and elastin, and middle layer thickness in these three fragments. RESULTS: In twelve ruptured and four unruptured aneurysms, the biomechanical analysis of the fragments showed no statiscally signicant differences between the mean values of the biomechanical properties (tension, stress, strain energy and strain), as well as the thickness of the fragments in the three groups. The percentage of collagen in the neck was significantly lower than in the aneurysm wall (p = 0,010) and was not significantly different from the suprarenal aorta (p = 0,155). Higher percentage of elastin was present in the neck (p < 0,001) and in the suprarenal aorta (p < 0,001) when compared to aneurysms. There was no difference in the quantification of elastin between the neck and the suprarenal segment (p = 0,457). The middle layer thickness showed no significant statistical difference between the three evaluated regions (p = 0,660). CONCLUSIONS: Biomechanical results suggest that the infrarenal aortic aneurysm, rather than a localized process, is a result of diffuse aortic involvement. Both the resistance and elasticity of the aneurysmal segment have similarities when compared to non-dilated aortic segments. In the histological analysis, there is preservation of elastin in non-dilated aortic segments, while there is a reduction in the aneurysmal wall; and there is greater collagen deposition in the aneurysmatic region
Haug, Erik Skaaheim. « Infrarenal abdominal aortic aneurysm : comorbidity and results following open surgery ». Doctoral thesis, Norwegian University of Science and Technology, Department of Circulation and Medical Imaging, 2005. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1772.
Texte intégralHadjianastassiou, Vassilis Georgiou. « Risk stratification modelling in post-operative abdominal aortic aneurysm patients ». Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491903.
Texte intégralQu, Zao, et 瞿早. « Expression of sphingosine-1-phosphate receptor in abdominal aortic aneurysm ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47050834.
Texte intégralAng, Lisa Shouning. « The extracellular role of granzyme B in abdominal aortic aneurysm ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45649.
Texte intégralLiu, Jing. « THE ROLE OF APOB-CONTAINING LIPOPROTEINS IN ABDOMINAL AORTIC ANEURYSM ». UKnowledge, 2015. http://uknowledge.uky.edu/pharmacol_etds/12.
Texte intégralO'Connell, Mary Kathleen. « Understanding abdominal aortic aneurysm progression through three-dimensional microstructure imaging / ». May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Texte intégralTroxler, M., Khalid M. Naseem et Shervanthi Homer-Vanniasinkam. « Increased nitrotyrosine production in patients undergoing abdominal aortic aneurysm repair ». Wiley, 2004. http://hdl.handle.net/10454/4094.
Texte intégralVascular inflammation is implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm (AAA), and is thought to involve reactive species such as the nitric oxide-derived oxidant peroxynitrite. In the present study nitrotyrosine was measured as a stable marker of peroxynitrite production in vivo. Perioperative blood samples were obtained from patients undergoing elective open or endovascular repair of an AAA and from patients with intermittent claudication, smoking aged-matched controls, non-smoking aged-matched controls and non-smoking young healthy controls. Plasma nitrotyrosine was measured by an enzyme-linked immunosorbent assay. The median plasma nitrotyrosine concentration in patients with an AAA (0·46 nmol nitrated bovine serum albumin equivalents per mg protein) was significantly higher than that in patients with intermittent claudication (0·35 nmol; P = 0·002), smoking controls (0·36 nmol; P = 0·001), non-smoking controls (0·35 nmol; P = 0·002) and young healthy controls (0·27 nmol; P < 0·001). Nitrotyrosine concentrations increased during early reperfusion in open AAA repair, but not during endovascular repair. AAA exclusion from the circulation reduced levels to control values (P = 0·001). Patients with an AAA had raised levels of circulating nitrated proteins compared with patients with claudication and controls, suggesting a greater degree of ongoing inflammation that was not related to smoking. Copyright