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Littérature scientifique sur le sujet « AARS2 »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "AARS2"

Lakshmanan, Rahul, Matthew E. Adams, David S. Lynch, et al. "Redefining the phenotype of ALSP and AARS2 mutation–related leukodystrophy." Neurology Genetics 3, no. 2 (2017): e135. http://dx.doi.org/10.1212/nxg.0000000000000135.

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Objective:To provide an overview of the phenotype of 2 clinically, radiologically, and pathologically similar leukodystrophies, adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and alanyl-transfer RNA synthetase 2 mutation–related leukodystrophy (AARS2-L), and highlight key differentiating features.Methods:ALSP and AARS2-L cases were identified from the adult-onset leukodystrophy database at our institution. In addition, cases with imaging findings were identified from a literature review. The phenotypic features were determined by combining published cases with those from our database.Results:A combined total of 74 cases of ALSP and 10 cases of AARS2-L with neuroimaging data were identified. The mean age at onset was 42 years in ALSP and 26 years in AARS2-L. Cognitive and motor symptoms were the most common symptoms overall in both. Ovarian failure was exclusive to AARS2-L, present in all known female cases. Both ALSP and AARS2-L showed a confluent, asymmetric, predominantly frontoparietal, periventricular pattern of white matter disease with subcortical U-fiber sparing; pyramidal tract and corpus callosum involvement; and diffusion changes in the white matter which we have termed “deep white matter diffusion dots.” Central atrophy and corpus callosal thinning were prominent in ALSP and disproportionately mild in AARS2-L when present. ALSP also occasionally showed ventricular abnormalities and calcifications in the frontal periventricular white matter, features not seen in AARS2-L. AARS2-L demonstrates white matter rarefaction which suppresses on fluid-attenuated inversion recovery MRI sequences, a feature not seen in ALSP.Conclusions:ALSP and AARS2-L share similar clinical, imaging, and pathologic characteristics with key differentiating features that we have highlighted.

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Axelsen, Tobias Melton, Tzvetelina Lubenova Vammen, Mads Bak, Nelsan Pourhadi, Christian Midtgaard Stenør, and Sabine Grønborg. "Case report: ‘AARS2 leukodystrophy’." Molecular Genetics and Metabolism Reports 28 (September 2021): 100782. http://dx.doi.org/10.1016/j.ymgmr.2021.100782.

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Bhardwaj, Priya, Christoffer Rasmus Vissing, Niels Kjær Stampe, et al. "Reassessment of Gene-Elusive Familial Dilated Cardiomyopathy Leading to the Discovery of a Homozygous AARS2 Variant—The Importance of Regular Reassessment of Genetic Findings." Cardiogenetics 11, no. 3 (2021): 122–28. http://dx.doi.org/10.3390/cardiogenetics11030013.

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Background: AARS2 encodes the mitochondrial protein alanyl-tRNA synthetase 2 (MT-AlaRS), an important enzyme in oxidative phosphorylation. Variants in AARS2 have previously been associated with infantile cardiomyopathy. Case summary: A 4-year-old girl died of infantile-onset dilated cardiomyopathy (DCM) in 1996. Fifteen years later, her 21-year-old brother was diagnosed with DCM and ultimately underwent heart transplantation. Initial sequencing of 15 genes discovered no pathogenic variants in the brother at the time of his diagnosis. However, 9 years later re-screening in an updated screening panel of 129 genes identified a homozygous AARS2 (c.1774C > T) variant. Sanger sequencing of the deceased girl confirmed her to be homozygous for the AARS2 variant, while both parents and a third sibling were all found to be unaffected heterozygous carriers of the AARS2 variant. Discussion: This report underlines the importance of repeated and extended genetic screening of elusive families with suspected hereditary cardiomyopathies, as our knowledge of disease-causing mutations continuously grows. Although identification of the genetic etiology in the reported family would not have changed the clinical management, the genetic finding allows genetic counselling and holds substantial value in identifying at-risk relatives.

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Dallabona, C., D. Diodato, S. H. Kevelam, et al. "Novel (ovario) leukodystrophy related to AARS2 mutations." Neurology 82, no. 23 (2014): 2063–71. http://dx.doi.org/10.1212/wnl.0000000000000497.

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Parra, Sahyli Perez, Stephan H. Heckers, William R. Wilcox, Colin David Mcknight, and H. A. Jinnah. "The emerging neurological spectrum of AARS2-associated disorders." Parkinsonism & Related Disorders 93 (December 2021): 50–54. http://dx.doi.org/10.1016/j.parkreldis.2021.10.031.

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van der Knaap, Marjo S., and Truus E. M. Abbink. "Ovarioleukodystrophy: Vanishing white matter versus AARS2-related ovarioleukodystrophy." Clinical Neurology and Neurosurgery 171 (August 2018): 195. http://dx.doi.org/10.1016/j.clineuro.2018.06.024.

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Szpisjak, Laszlo, Nora Zsindely, Jozsef I. Engelhardt, Laszlo Vecsei, Gabor G. Kovacs, and Peter Klivenyi. "Novel AARS2 gene mutation producing leukodystrophy: a case report." Journal of Human Genetics 62, no. 2 (2016): 329–33. http://dx.doi.org/10.1038/jhg.2016.126.

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Kuo, Molly E., Anthony Antonellis, and Vikram G. Shakkottai. "Alanyl-tRNA Synthetase 2 (AARS2)-Related Ataxia Without Leukoencephalopathy." Cerebellum 19, no. 1 (2019): 154–60. http://dx.doi.org/10.1007/s12311-019-01080-y.

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Taglia, I., I. Di Donato, S. Bianchi, et al. "AARS2-related ovarioleukodystrophy: Clinical and neuroimaging features of three new cases." Acta Neurologica Scandinavica 138, no. 4 (2018): 278–83. http://dx.doi.org/10.1111/ane.12954.

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Bruwer, Zandrè, Nihal Al Riyami, Tamima Al Dughaishi, et al. "Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: a single center experience." Journal of Perinatal Medicine 46, no. 9 (2018): 968–74. http://dx.doi.org/10.1515/jpm-2017-0124.

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Abstract Objective: The purpose of this study was to determine the frequency of non-immune hydrops fetalis (NIHF) among all pregnancies referred for prenatal care at Sultan Qaboos University Hospital (SQUH) during the study period and to evaluate the underlying etiologies of NIH. Study design: All pregnancies referred to SQUH between February 2014 and December 2015 were identified, and all pregnancies meeting the diagnosis of NIHF were included in this study. All cases of NIHF referred to our center during this period underwent standard systematic diagnostic work-up that included biochemical and molecular studies in addition to the standard investigations for hydrops fetalis. Clinical characteristics and results of the diagnostic work-up were retrospectively reviewed. Results: A total of 3234 pregnancies were referred for prenatal care at SQUH during the study period, and 12 pregnancies were affected by NIHF. An underlying diagnosis was established in nine cases, and the majority of cases (7/9) were caused by inborn errors of metabolism (IEM). These included a novel homozygous variant in the AARS2 gene (5/7) and two cases of galactosialidosis (2/7). Conclusion: IEM was a major cause of NIHF in this cohort. The AARS2 variant accounts for a significant number of cases with NIHF in this cohort of Omani patients.

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Thèses sur le sujet "AARS2"

DIODATO, DARIA. "Identification and functional validation of new mtDNA and nuclear gene variants responsible for mitochondrial disorders." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50549.

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My project has been focused on the identification and validation of new mitochondrial gene variants and new mitochondria-related genes. The first report is about a woman presenting with a stroke-like episode and an history of severe hearing loss, frequent migraines, exercise intolerance, myalgias and limb-girdle muscle weakness indicating a slowly progressive myopathy and secondary amenorrhea with low gonadotropin levels. A muscle biopsy showed ragged-red, cytochrome c oxidase-negative fibers, and an isolated defect of cytochrome c oxidase activity in muscle mitochondria and sequence analysis of muscle mtDNA revealed a new heteroplasmic m.6597C>A transversion in the MTCOI gene, encoding subunit I of cytochrome c oxidase. Analysis on transmitochondrial cybrids demonstrated that the mutation is indeed associated with COX deficiency, i.e. pathogenic. The second report is about a new phenotype associated to mutations in the AARS2 gene encoding for the mitochondrial aminoacyl tRNA synthetase, identified in six patients presenting with primary ovarian failure, cerebellar and pyramidal signs and cognitive or behavioural disturbances. Two patients underlined a muscle biopsy which showed a severe complex IV defect at histochemical and biochemical analyses. The third report is about the clinical and biochemical phenotypes associated with mutations in two new mitochondrial aminoacyl tRNA synthetases (ARSs2) genes. In the first patient, an 8 years old child presenting with psychomotor delay, seizures, facial dysmorphisms and hyperlactacidemia and a brain MRI showing hyperintense lesions in the insula and fronto-temporal right cortex, whole exome sequencing (WES) identified a homozygous missense mutation in VARS2, encoding the mitochondrial valyl tRNA-synthetase. In two siblings presenting with a phenotype characterized by hypotonia and psychomotor retardation, high plasma and liquor lactate, both died at few months of age WES revealed two variants in TARS2, encoding the mitochondrial threonyl tRNA-synthetase: a missense and a splice site mutation. VARS2 and TARS2 mutations segregate within patients families. Patients’ clinical- biochemical phenotype and in silico and in vitro analyses of VARS2 and TARS2 mutations clearly indicate these genes as disease-causative. Expression of the corresponding wild-type enzymes led to recovery of the biochemical impairment of mitochondrial respiration in immortalized mutant fibroblasts; yeast modelling of the VARS2 mutation confirmed its pathogenic role.

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Hausmann, Corinne D. "Multi-Aminoacyl-Trna Synthetase Complexes In Archaeal Translation." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213641006.

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Guth, Ethan. "tRNA Identity Mediated Control of the Catalytic mechanism in E. coli Histidyl-tRNA Synthetase." ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/98.

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The aminoacyl-tRNA synthetases (aaRSs) are the universal set of enzymes responsible for attaching amino acids to tRNA to be used as substrates in the process of protein translation. As these enzymes act at the transition between nucleic acids and proteins, their specificity of action is critical for maintaining the fidelity of the genetic code. From a mechanistic standpoint, aaRS specificity is enforced by a complex series of tRNA structural and chemical elements that collectively make up its identity set and serve to distinguish one tRNA from another. Based on sequence, structure, and oligomeric differences, the aaRS family has been partitioned into two classes, each of which is responsible for roughly half of the 22 genetically encoded amino acids. In the studies presented here, pre-steady-state kinetic methods were employed to measure individual events that collectively make up the catalytic cycle of the class II Escherichia coli Histidyl-tRNA Synthetase (HisRS) in order to elucidate the nature of its enzymatic activity and determine how these events contribute to the exquisite specificity between enzyme and tRNA. The results presented here indicate indentiy elements of tRNAHis regulate the activity of the amino acid activation and aminoacyl transfer half reactions. Additional evidence suggests communication between active sites of the HisRS homodimer plays a role in establishing an alternating cycle of catalysis in the steady state.

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Sanders, Michael. "THE EFFECT OF IMMEDIATE FEEDBACK AND AFTER ACTION REVIEWS (AARS) ON LEARNING, RETENTION AND TRANSFER." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3657.

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An After Action Review (AAR) is the Army training system's performance feedback mechanism. The purpose of the AAR is to improve team (unit) and individual performance in order to increase organizational readiness. While a large body of knowledge exists that discusses instructional strategies, feedback and training systems, neither the AAR process nor the AAR systems have been examined in terms of learning effectiveness and efficiency for embedded trainers as part of a holistic training system. In this thesis, different feedback methods for embedded training are evaluated based on the timing and type of feedback used during and after training exercises. Those feedback methodologies include: providing Immediate Directive Feedback (IDF) only, the IDF Only feedback condition group; using Immediate Direct Feedback and delayed feedback with open ended prompts to elicit self-elaboration during the AAR, the IDF with AAR feedback condition group; and delaying feedback using opened ended prompts without any IDF, the AAR Only feedback condition group. The results of the experiment support the hypothesis that feedback timing and type do effect skill acquisition, retention and transfer in different ways. Immediate directive feedback has a significant effect in reducing the number of errors committed while acquiring new procedural skills during training. Delayed feedback, in the form of an AAR, has a significant effect on the acquisition, retention and transfer of higher order conceptual knowledge as well as procedural knowledge about a task. The combination of Immediate Directive Feedback with an After Action Review demonstrated the greatest degree of transfer on a transfer task. M.S. Department of Industrial Engineering and Management Systems Engineering and Computer Science Industrial Engineering and Management Systems

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Schwerdtner, Annegret [Verfasser], and Florian [Akademischer Betreuer] Baumann. "Atlanto-axiale Rotationssubluxation (AARS) im Kindesalter - Diagnostik, Therapie und Langzeitergebnisse aus manualmedizinischer Sicht / Annegret Schwerdtner ; Betreuer: Florian Baumann." Regensburg : Universitätsbibliothek Regensburg, 2020. http://d-nb.info/1204635889/34.

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Aarse, Janna Maria [Verfasser], Denise [Gutachter] Manahan-Vaughan, and Stefan [Gutachter] Herlitze. "Investigations of the functional mechanisms underlying communication between the cerebellum and the hippocampus / Janna Maria Aarse ; Gutachter: Denise Manahan-Vaughan, Stefan Herlitze." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1125106026/34.

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Kuzmishin, Nagy Alexandra Burden. "Maintaining Fidelity of Translation by Bacterial Trans-Editing Proteins:Caulobacter crescentus ProXp-ala and Rhodopseudomonas palustris ProXp-x." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563478757446243.

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Holmborn, Towe. "Zooplankton growth and trophic linkages : Implications for fish feeding conditions in the Baltic Sea." Doctoral thesis, Stockholms universitet, Systemekologiska institutionen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29485.

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The aim of this Thesis was to improve our understanding and assessment of feeding conditions for zooplanktivorous fish in the Baltic Sea. We investigated (papers I, II) the usefulness of biochemical proxies for assessments of growth and metabolic rates in the dominant Baltic copepod Acartia bifilosa. A predictive model (paper I) for egg production rate (EPR), based on body size, RNA content, and water temperature, was established using females of different geographical origin. This model demonstrates the usefulness of RNA content as a proxy for growth in zooplankton and, together with abundance data, it could be used to evaluate fish feeding conditions. Further (paper II), using A. bifilosa exposed to a food gradient, we evaluated responses of physiological rates and other biochemical proxies for growth and established correlations between physiological and biochemical variables. EPR and ingestion rate were most significantly correlated with RNA content. As assayed variables saturated at different food concentrations, food availability may affect assessments of physiological rates using proxies. In paper III, we explored the effect of high EPR and ingestion rate on astaxanthin content in A. bifilosa. We found that the astaxanthin content decreased at high feeding rates, most likely due to decreased assimilation efficiency. This may impact the quality of zooplankton as prey. The invasion of Cercopagis pengoi, a zooplanktivorous cladoceran, has altered the trophic linkages in the Baltic Sea food web. In paper IV, we evaluated the feeding of zooplanktivorous fish on C. pengoi and found that irrespective of size both herring and sprat feed on it, with large herring being more selective. In turn, C. pengoi feeds mainly on older copepods (paper V), which are acknowledged important in fish nutrition. These results indicate that C. pengoi may compete with fish due to the diet overlap. At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: In progress. Paper 3: Submitted

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Gonzalez, Serrano Ligia Elena. "Caractérisation de l'ArgRS mitochondriale humaine et contribution à la compréhension des pathologies liées aux mutations des aminoacyl-ARNt synthétases mitochondriales." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ074/document.

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Les aminoacyl-ARNt synthétases mitochondriales humaines (aaRS mt) sont des enzymes clés de la traduction mitochondriale. Elles catalysent l'aminoacylation des ARNt par les acides aminés correspondent. Des mutations dans leurs gènes sont corrélées à des pathologies avec un large spectre de phénotypes cliniques, mais aux mécanismes moléculaires sous-jacents encore incompris. L'objectif de ce travail de thèse s'intègre dans les axes scientifiques du laboratoire, mais élargit l'intérêt et les connaissance à un système encore peu exploré: l'arginyl-ARNt synthétase mitochondriale (ArgRS mt). Des mutations dans la ArgRS sont liées à une hypoplasie Pontocérébelleuse (PCH6), une pathologie neurodéveloppementale sévère. Le travail de cette thèse s’articule autour de 3 axes : (I) L’analyse des phénotypes cliniques des pathologies liées aux mutations dans les aaRS mt, (II) La caractérisation des propriétéscellulaires de l’ArgRS mt, et (III) L'étude de l’impact de mutations « pathologiques » sur diverses propriétés de l’ArgRS mt. Combinés avec les travaux précédents, les résultats obtenus sont une contribution importante à l'élargissement des connaissances fondamentales des mt aaRSs, et apportent un nouvel éclairage sur le lien entre les mt-aaRSs-mutations et la maladie Human mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are housekeeping enzymes involved in the mitochondrial translation. They catalyze the aminoacylation of tRNAs with their cognate amino acids. Mutations in their nuclear genes are correlated with pathologies with a broad spectrum of clinical phenotypes, but with so far no clear explanations about the underlying molecular mechanism(s). The aim of this PhD work follows the long-standing efforts of the host laboratory but expand the interest and knowledge to an unexplored system: the human mitochondrial arginyl-tRNA synthetase (mt-ArgRS). Mutations in the mt-ArgRS lead to Pontocebellar hypoplasia type 6, a severe neuro-developmental pathology. I thus contributed to i) comprehensively analyze the clinical data reported in pathologies related to mutations on mt-aaRSs, resulting in a categorization according to the affected anatomical system; ii) decipher some cellular properties of the mt-ArgRS; and iii) investigate to impact of disease-associated mutations on mt-aaRSs properties. Combined with previous works, the present results expand the knowledge of the mt-aaRSs, shedding new light on the link between mt-aaRSs-mutations and disease

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Galatolo, Daniele. "An integrated, next-generation approach to identify new genes and new pathways in hereditary ataxias." Doctoral thesis, 2020. http://hdl.handle.net/2158/1188709.

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The Hereditary ataxias (HAs) are a group of heterogenous neurological disorders associated with multiple genetic etiologies and encompassing a wide spectrum of phenotypes, where ataxia is the prominent feature. HAs are characterized by degeneration of Purkinje cell and/or spinocerebellar connections, often associated with defects in additional brain structures, and all patterns of inheritance may occur. Similar to other fields of medical genetics, Next Generation Sequencing (NGS) has entered the HA scenario widening our genetic and clinical knowledge of this condition, but routine NGS applications still miss genetic diagnosis in about two third of patients. In this doctoral study, we applied multi-gene panels to define the molecular basis in 259 patients with a clinical diagnosis of HA and negative to tests for pathological expansion in SCA1, 2, 3, 6, 7, 8, 12, 17 and FXN. We found a positive molecular diagnosis in 25% of patients, whereas a similar number of patients had an uncertain diagnosis due to the presence of either variants of uncertain significance or lack of biological samples to determine segregation among family members. Hence despite a higher positive diagnostic rate compared to similar studies described in literature, a half of patients lacked any indication of the genetic cause of their disease. Using exome sequencing as a second-tier approach in some families, refractory to multi-gene panel analysis, did not significantly improved our diagnostic yield. On the other hand, NGS analysis in our cohort indicated that familial cases were more easily diagnosed rather than sporadic cases, and also that combining massive sequencing with detailed clinical information and family studies increases the likelihood to reach a molecular diagnosis. Among positive patients, we could expand clinical and allelic information in a subgroup of genes offering original description of new mutations and corroborating genetic findings with functional investigations that took advantage of different in vitro or in vivo platforms. In particular, through functional studies in SPG7 knock-down models of Drosophila melanogaster, we remarked that SPG7, whose mutations cause spastic paraplegia type 7, has a critical role in neurons more than in skeletal muscle. The high frequency of p.Ala510Val mutation in SPG7 observed in our cohort as well in similar studies performed elsewhere moved us to develop a humanized knock-in fruit fly model harboring that specific mutation and prepare preliminary characterizations. Similar studies in fruit fly were performed silencing AFG3L2, the gene causing SPAX5 in a child in association with an unusual, relatively milder phenotype. Furthermore, combination of skin fibroblasts and Saccharomyces cerevisiae as models was employed in the genetic characterization of new mutations in a novel recessive HARS-related phenotype whereas primary human cells, yeast and Danio rerio models were used to functionally characterize new HA-related mutations in COQ4. Finally, we could expand the clinical presentation of rare causes of HAs describing new dominant mutations in STUB1 and biallelic variants in RFN216, COQ8A, and ATP13A2. Altogether, studies performed during this doctoral work further underlined the usefulness of NGS in HAs and highlighted how NGS technologies rely on the integrated use of family and clinical studies and different in vitro/in vivo platforms to substantiate molecular findings. The latter platform will be also a tool for future investigations to dissect pathogenesis and to improve therapies.

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Livres sur le sujet "AARS2"

Verhelst, Peter. Aars!: Anatomische studie van de Oresteia. Prometheus, 2000.

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Tyve aars kamp: Tilageblik og fremsyn. Norges allmennvitenskapelige forskningsrad, 1985.

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Hansteen, Aasta. Tyve aars kamp: Tilbageblik og fremsyn. [Norges allmennvitenskapelige forskningsråd], 1985.

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Kirkeby, Per. At bygge i Aars: Skitser til musikhus. Vesthimmerlands gymnasium, 1996.

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Burney, DeAnna McKinnie. AARS: Adolescent Anger Rating Sale : professional manual. Psychological Assessment Resources, 2001.

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United Nations. Economic Commission for Africa and GIS Society of Ethiopia, eds. AARSE 2010: 8th AARSE Conference, Addis Ababa, Ethiopia, October 25-29, 2010 : earth observation for Africa's development agenda : scientific symposium, exhibition, workshops. GISSE, 2010.

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Jensen, Peter Klint. Preliminary simulations of transformation ratios for the Danish Well AARS - 1A. Riso National Laboratory, 1986.

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Verhelst, Peter. Aars!: Anatomische studie van de Oresteia. Prometheus, 2000.

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Sharma, Pankaj. AarSu a Soul for a Soul: The Mystery of the Golden Showers. Independently Published, 2020.

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Ltd, ICON Group. AARS BANK A/S: Labor Productivity Benchmarks and International Gap Analysis (Labor Productivity Series). 2nd ed. Icon Group International, 2000.

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Chapitres de livres sur le sujet "AARS2"

Mathews, Rick C. "Exercises and AARs in Emergency Management." In Principles of Emergency Management and Emergency Operations Centers (EOC), 2nd ed. CRC Press, 2021. http://dx.doi.org/10.4324/9781315118345-11.

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Townsend, Lisa, Joan Johnston, William A. Ross, Laura Milham, Dawn Riddle, and Henry Phillips. "An Integrated After Action Review (IAAR) Approach: Conducting AARs for Scenario-Based Training Across Multiple and Distinct Skill Areas." In Engineering Psychology and Cognitive Ergonomics. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-91122-9_20.

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"aaRS." In Encyclopedia of Biophysics. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-16712-6_100025.

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Quek, Chai, Zaiyi Guo, and Douglas L. Maskell. "A Novel Fuzzy Associative Memory Architecture for Stock Market Prediction and Trading." In Contemporary Theory and Pragmatic Approaches in Fuzzy Computing Utilization. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-1870-1.ch007.

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In this paper, a novel stock trading framework based on a neuro-fuzzy associative memory (FAM) architecture is proposed. The architecture incorporates the approximate analogical reasoning schema (AARS) to resolve the problem of discontinuous (staircase) response and inefficient memory utilization with uniform quantization in the associative memory structure. The resultant structure is conceptually clearer and more computationally efficient than the Compositional Rule Inference (CRI) and Truth Value Restriction (TVR) fuzzy inference schemes. The local generalization characteristic of the associative memory structure is preserved by the FAM-AARS architecture. The prediction and trading framework exploits the price percentage oscillator (PPO) for input preprocessing and trading decision making. Numerical experiments conducted on real-life stock data confirm the validity of the design and the performance of the proposed architecture.

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Denham, Magdalena, and Ashish Kumar Khemka. "Reducing Risk Through Academic Community Engagement in Homeland Security and Emergency Management." In Research Anthology on Service Learning and Community Engagement Teaching Practices. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3877-0.ch080.

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This inquiry engaged graduate students in the Homeland Security and Emergency Management program course designated as Academic Community Engagement (ACE) at an Institution of Higher Education (IHE) in rural Texas. The purpose was to evaluate an American Red Cross (ARC) risk-reduction Home Fire Campaign initiative and to implement new strategies designed by students and grounded in after action reports (AARs) and principles of emergency management (EM). Vygotsky's model of social learning and Cultural Historical Activity Theory (CHAT) framed the study. Students partnered with the ARC, emergency responders, and civil society organizations to (a) assess the effectiveness of the ARC-led campaign; (b) apply EM principles in designing the student-led campaign; (c) implement EM principles to new capability-building strategies; and (d) offer recommendations. Comparative analyses of separate campaign events in the community revealed reciprocal benefits; solutions devised by students enhanced program effectiveness and expanded social capital; students reported deep contextualized learning.

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Actes de conférences sur le sujet "AARS2"

Benoit, Michael J. "AARS: The Automated Aircraft Rework System." In Aerofast Conference & Exposition. SAE International, 1995. http://dx.doi.org/10.4271/952180.

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Davidson, David B., Pietro Bolli, Mirko Bercigli, et al. "Electromagnetic modelling of the SKA-LOW AAVS2 prototype." In 2020 XXXIIIrd General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS). IEEE, 2020. http://dx.doi.org/10.23919/ursigass49373.2020.9232307.

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Sokolowski, M., J. W. Broderick, R. B. Wayth, et al. "Preliminary sensitivity verification of the SKA-Low AAVS2 prototype." In 2021 15th European Conference on Antennas and Propagation (EuCAP). IEEE, 2021. http://dx.doi.org/10.23919/eucap51087.2021.9410962.

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Gibson, Joseph W. "After Action Review System (AARS) design and functional capabilities." In the 27th conference. ACM Press, 1995. http://dx.doi.org/10.1145/224401.224807.

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Benoit, Michael. "The Automated Aircraft Rework System (AARS) - A system integration approach." In Conference on Intelligent Robots in Factory, Field, Space, and Service. American Institute of Aeronautics and Astronautics, 1994. http://dx.doi.org/10.2514/6.1994-1225.

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Li, Mingrui, and Meng Su. "Phylogenetic Analysis of aaRS Reveals the Kinship of Amino Acids." In ICCBB '21: 2021 5th International Conference on Computational Biology and Bioinformatics. ACM, 2021. http://dx.doi.org/10.1145/3512452.3512459.

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"What LEGAD needs to know? Analysis of AARs from Locked Shields (2012-2018)." In The 19th European Conference on Cyber Warfare. ACPI, 2020. http://dx.doi.org/10.34190/ews.20.075.

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Biswas, Saiib K., Pranab K. Muhuri, and Uttam K. Roy. "AARS: A novel adaptive archive-based efficient counting method for machine learning applications." In 2022 IEEE International Conference on Data Mining Workshops (ICDMW). IEEE, 2022. http://dx.doi.org/10.1109/icdmw58026.2022.00085.

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Davidson, David B., and D. Ung. "Spectral smoothness of embedded element patterns in the SKA-LOW prototype station AAVS2: preliminary results." In 2021 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting (APS/URSI). IEEE, 2021. http://dx.doi.org/10.1109/aps/ursi47566.2021.9704644.

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Boyle, N., B. Archambault, A. Hagen, C. Meert, and R. P. Taleyarkhan. "Detection of Radon-Progeny and Other Alpha-Emitting Radionuclides in Air Using Tensioned Metastable Fluid Detectors." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-66805.

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Résumé :

Alpha radiation emitting radon (Rn) gas seepage into homes in the USA leads to over 21,000 annual lung cancer deaths (according to the US-Environmental Protection Agency, EPA) leading to mandatory monitoring for Rn throughout the USA. In the nuclear industry alpha emitting radionuclides in air (e.g., in spent fuel reprocessing) also constitute a major safety and security-safeguards related issues. Purdue University, along with Sagamore Adams Laboratories LLC, is developing the tensioned metastable fluid detector (TMFD) technology for general-purpose alpha-neutron-fission spectroscopy. This paper focuses on rapid, high-efficiency detection of Rn and progeny in air using the novel TMFD technology; Rn and progeny isotopes in air are sparged through the TMFD detection fluid (to entrap the radioactive gas), which is then placed under a metastable state. Through tailoring the metastable fluid state, an audible and visible cavitation detection event is created and readily detected from transient bubble formation. Changing the tensioned state allows for the spectroscopic differentiability of Rn and its daughters which can be used to actively measure the equilibrium between the parent and daughter products. Such a technique can also be used to monitor the atmosphere in critical nuclear facilities for contamination from other alpha emitting isotopes (e.g., Pu, Cm, U...). TMFDs offer the unique ability for high intrinsic efficiency (>95%) alpha-neutron-fission fragment detection, while remaining blind to background beta and gamma radiation (qualified to >3.8×108 Bq m−3 using a dissolved 32P beta source, and also via gammas from a 53 R/hr 137Cs gamma source). Immunity to beta and gamma is beneficial for the discrimination of buildup of beta-emitting Thoron and Rn progeny in the detection fluid allowing for reusability. This paper will discuss the research results pertaining to detection of Radon and progeny in air, for concentrations between 74 Bq m−3 (2 pCi/L) and 740 Bq m−3 (20 pCi/L). The system measures a radon concentration between these levels to within ±15% intrinsic relative error (IRE) within 24 hours meeting the standards outlined by the American Association of Radon Scientists and Technicians-National Radon Proficiency Program (AARST-NRPP) Device Evaluation Program. Precision evaluation was also performed and the relative standard deviation defined by the AARST-NRPP was <5% exceeded the requirement of 25%. Ambient temperature effects were assessed at 10 °C and at 27 °C, which revealed a large increase in collection efficiency with decreasing sampling temperature and slight increase with increasing sampling temperature. Temperature effects on sensitivity thresholds and volumetric expansion were measured and used to compensate for variability in temperature over time. Blind testing with the help of Bowser-Morner Radon Reference Laboratory was performed and succeeded in accurately determining the Rn in air concentration to within 20% within only 6h of sampling. Finally, a 48-hour based collection time has also been developed for use in dwellings where Rn in air concentrations may vary in a day. Overall, the reproducibility and precision of TMFD technology is found to allow for an efficient, cost-effective, reliable, and environmentally friendly means of Rn and progeny detection, and by extension for use for general actinide in air monitoring for the nuclear industry.

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Rapports d'organisations sur le sujet "AARS2"

Athey, J. E., and A. L. Nash. Alaskas story of radon challenges in a big, arctic, far-flung U.S. state (poster): 2022 American Association of Radon Scientists and Technologists (AARST) International Radon and Vapor Intrusion Symposium, Bellevue, Washington, October 24-26, 2022. Alaska Division of Geological & Geophysical Surveys, 2022. http://dx.doi.org/10.14509/30913.

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