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Poznarová, Vendula. « 4 + 4 ». Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2015. http://www.nusl.cz/ntk/nusl-253754.
Texte intégralAraya, Naranjo Sandra. « Población de una base de datos jurisprudencial a base de libros de registro de sentencias de protección de la corte suprema, mayo 3-3, año 2004, julio 1-4, 2-4, 3-4, 4-4, año 2004, diciembre 1-4, 2-4, 3-4, 4-4, año 2004 ; enero 1-4, 2-4, 3-4, 4-4 año 2005, febrero 1-2, 2-2, año 2005 ». Tesis, Universidad de Chile, 2005. http://www.repositorio.uchile.cl/handle/2250/113738.
Texte intégralNo autorizada por el autor para ser publicada a texto completo
En la realización de la Tesis analice 356 fallos emanados de la Ilustrísima Corte Suprema de Justicia, de ellos se extractaron definitivamente 322 fallos, en su mayoría son Recursos de Protección, aunque también fueron analizados en menor número Recursos de Amparo Económico.
Berretil, Slimane. « Proprietes electroniques des semi-conducteurs magnetiques gamo : :(4)s ::(8), gamo ::(4)se ::(8), gamo ::(4)se ::(4)te ::(4) et ganb ::(4)s ::(8) ». Paris 6, 1987. http://www.theses.fr/1987PA066262.
Texte intégralMoura, Silio Lima de. « Electrochemistry of 4-[(4-aminobenzene) sulfonyl] phenylamine ». Instituto Tecnológico de Aeronáutica, 2015. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=3312.
Texte intégralCenter, University of Arizona Water Resources Research. « Arroyo Vol. 4 No. 4 (February 1991) ». Water Resources Research Center, College of Agriculture, University of Arizona (Tucson, AZ), 1991. http://hdl.handle.net/10150/314794.
Texte intégralHuhn, Daniel M. « Rejoice in the Lord always Philippians 4:4 / ». Theological Research Exchange Network (TREN), 1986. http://www.tren.com.
Texte intégralBulloch, Esther Marcella MacLeod. « Mechanistic studies of 4-amino-4-deoxychorismate synthase ». Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597075.
Texte intégralDukhan, David. « Synthèse de 4'-thio-oligoribonucléotides (4'-S-ARN) ». Montpellier 2, 1999. http://www.theses.fr/1999MON20038.
Texte intégralPapet, Anne-Laure. « Complexes d'europium luminescents a unités 4, 4'-bipyrimidines ». Nancy 1, 1993. http://www.theses.fr/1993NAN12444.
Texte intégralPapet, Anne-Laure. « Complexes d'europium luminescents a unités 4, 4'-bipyrimidines ». Nancy 1, 1993. http://www.theses.fr/1993NAN10444.
Texte intégralDennehy, John Anthony. « A 4 ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://ndltd.ncl.edu.tw/handle/98312753620992735017.
Texte intégralEbert, Doreen. « 4 walls + ». Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/33424.
Texte intégralMaster of Architecture
Ruhland, James Randolph III. « 4 Theatres… ». Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/32004.
Texte intégralMaster of Architecture
Ecker, James Sherwood. « D+4 ». Xavier University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=xavier1352821786.
Texte intégralCrispino, Anna Lisa. « Commento a Ov. Pont. 4, 8 e 4, 9 ». Doctoral thesis, Universita degli studi di Salerno, 2014. http://hdl.handle.net/10556/1432.
Texte intégralIl quarto libro dei Pontica ha un’importanza fondamentale all’interno dell’intera raccolta, per le tematiche affrontate e per la peculiarità delle riflessioni a cui il poeta approda in questa parte della raccolta, un unicum rispetto alla poesia precedente. L’ultimo commento al quarto libro è quello di di Helzle del 1989. Tale commento, in origine una tesi di dottorato, si limita a commentare le prime sette elegie del quarto libro e la sedicesima, tralasciando, di fatto, quella elegia, la ottava, che, a giusto titolo, da Galasso è stata definita un proemio al mezzo, perché un condensato sul ruolo e l’attività del poeta, e la nona, perfettamente armonizzata con l’elegia precedente in quanto piena esemplificazione della poesia celebrativa soltanto teorizzata nel precedente componimento e introduzione perfetta delle tematiche della seconda parte della raccolta. Il poeta, costretto lontano da Roma, non intende chiudersi nel proprio mondo ma tenta ogni strada possibile, concependo una poesia che venga incontro alle necessità dei destinatari a cui si rivolge. Ciò che può garantire è la gloria eterna, che nasce dal ricordo nella sua poesia. L’esule emarginato riorganizza, lontano da Roma, la sua realtà precedente, attraverso la poesia e la sua mente, surrogato della vista, che gli permette, egli spera, di partecipare come può agli eventi importanti della vita pubblica romana, come l’inizio del consolato di Grecino. Il nuovo modo di far poesia è dettato dalla particolare situazione dell’esiliato che necessita di appoggi. La figura del princeps e dell’ambiente di corte, dei membri dell’elite politica divengono una presenza invadente, ricompaiono le dediche personali e trasformano l’intimità dell’amicizia in deferenza clientelare. Talvolta sono state rivolte ad Ovidio accuse di piaggeria, Ovidio è stato talvolta definito il primo dei poeti cortigiani (si guardi Grimal, 1968). La poesia concepita in queste elegie ovidiane dà indubbiamente l’immagine di Ovidio poeta nuovo, che adopera spunti e materiali per la costruzione di un progetto poetico innovativo, che mostra un poeta spettatore e partecipe, protagonista quanto mai prima della poesia, rivendicatore di una posizione sociale che non gli appartiene più. La nuova poesia è costituita da carmi che troverebbero l’approvazione augustea, una poesia non tanto distante da Tristia e Pontica, più compatibile con la nuova realtà in cui il poeta è protagonista e partecipe, quella in cui rivendica con forza la propria appartenenza, una poesia che non può che essere la poesia d’occasione. Non è rintracciabile in questa nuova poesia una precisa ed esplicita volontà da parte di un destinatario, che quindi non è un committente, Ovidio non è un cliens. Del resto il nuovo genere poetico, la poesia d’occasione, trova spazio già precedentemente: è Ovidio stesso ad informarci in Pont. 1, 2, 129-132 di aver composto un epitalamio per le nozze di Paolo Fabio Massimo e in Pont. 1, 7, 29 ss. di aver composto in occasione della morte del padre di Messalino un carme recitato poi ai suoi funerali nel foro. Sebbene non se ne conservi traccia Ovidio svolgeva, dunque, attività di poeta d’occasione. L’irrigidirsi dei rapporti con il princeps, il sistema piramidale di rapporti e la progressiva creazione di un linguaggio formulare e adulatorio cliens patronus modificano radicalmente la poesia ovidiana e la poesia di omaggio personale diventano parte della sua opera. [a cura dell'autore]
XII n.s.
Ohta, Takeshi. « Pharmacological effect of a novle antidiabetic agent, trans-4-(4-methylcyclohexyl)-4-oxobutyric acid, in rats ». Kyoto University, 1999. http://hdl.handle.net/2433/181408.
Texte intégralMATHE, LAURENCE. « Synthese et etudes pharmacologiques in vivo et in vitro des proprietes antalgiques d'une nouvelle famille de 1-aminotetralines disubstituees en position 4 (4-aryl-4-methyl et 4-aryl-4-trifluoromethyl) ». Paris 6, 1993. http://www.theses.fr/1993PA066171.
Texte intégralWajngot, Avital. « Fridskränkningsbrott eller olaga förföljelse ? : en analys av gränsdragningen mellan 4 kap. 4 a och 4 b § § BrB ». Thesis, Stockholms universitet, Juridiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-94927.
Texte intégralScartazzini, Luiz Silvio. « Medidas termodinamicas e eletricas na serie homologa do 4 (4'-n- nanoxibenzoiloxi) benzilideno 4" ; -n- alcoxianilina ». reponame:Repositório Institucional da UFSC, 1987. http://repositorio.ufsc.br/xmlui/handle/123456789/75400.
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Neste trabalho são apresentadas propriedades termodinâmicas e elétricas da série homóloga do 4(4'-n-nanoxibenzoiloxi) benzilideno 4"-n-alcoxianilina. Submetendo-se amostras de cada composto da série à variações da temperatura e com o auxílio do microscópio de luz polarizada e do calorímetro diferencial de varredura, foram determinadas as temperaturas de transição das fases mesomórficas e suas respectivas variações de entalpia. Em alguns compostos desta série, com o auxílio do conjunto de ponte de capacitância, foram investigadas as constantes dielétricas na fase nemática para determinar o sinal da anisotropia dielétrica. Da série n-metilen-bis(4-oxi-fenilen-carboxi 4-fenilenoxi heptila) foram investigadas as constantes dielétricas em dois compostos, para determinar o sinal da anisotropia dielétrica.
Jones, Tiffany Celeste. « Syndecan-4 binds insulin-like growth factor binding protein-4 ». Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/jones.pdf.
Texte intégralIngelmark, Emelie. « Var går gränsen ? : tillämpning av 4:4 miljöbalkens geografiska begränsningar ». Thesis, KTH, Fastigheter och byggande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211039.
Texte intégralThis study aims to investigate the practical use of the 4:4 Environmental Code in Sweden. The paragraph regulates national interest areas of high-exploited coast where only vacation buildings exceptionally may be constructed and in that case the vacation buildings must make a complement to the already existing settlement or they must make a natural rounding to an already built area. The coastal areas this paragraph regulates specifies some location name s, but it is still not clear which geographical limits to apply. For example, how far inland does the coastal area extends. Where is the limit? In this work four legal cases are treated. These cases are within the field of exploitation in the national interest area where 4:4 Environmental Code have been a key paragraph. All the legal cases refer to the time after the Environmental Code became legally valid in 1998. One of these legal cases showed that the 4:4 Environmental Code was not applicable and the question was sent back to the municipality for further processing. Thereby it is not clear if there was any exploitation in the case in the end. What I generally find in the legal cases is that the courts often sentence so that there is no exploitation, but that it is private individuals which live in the current area, that take the case to court and not the municipality. In this study, county governments and municipalities were contacted to get a better understanding of how 4:4 Environmental Code is used. The municipalities that where studied in this work have some very different management of 4:4 Environmental Code. Some municipalities have a lot of pressure on exploitation in coastal areas while other municipalities have less pressure, and the amount of errands with connection to 4:4 Environmental Code seems to match the exploitation interest. Something that several representatives of the municipalities bring up in the conducted interviews is the lack of some sort of template or something similar that clarifies the values the Code intend to protect, definitions of word in the law such as “urban area” and “vacation building”, and what development is being sought. In general, the information regarding the national interests available on the websites of the chosen county governments respectively, is the same. What is usually brought up, regarding the fourth chapter in the Environmental Code or generally about national interest s, is a rendering of the paragraph, a reference to where in the county this paragraph is applicable and thereafter a closure with another reference to a GIS-map. The county governments and the municipalities apply 4:4 Environmental Code differently. What the most county governments and municipalities seem to have in common is their use of the GIS-map. The studied municipalities in this work have many different managements of 4:4 Environmental Code. This is because, as in the case with the county governments, that the pressure on exploitation varies and thereby does the amount of errands about 4:4 Environmental Code vary as well. For further research, I consider that a clarification of the 4:4 Environmental Code is necessary. Furthermore, there should be an inventory to see if the paragraph’s regulated areas are still current enough to be classified as national interest areas. Also the definition of other words in 4:4 Environmental Code would be desirable, such as a definition of “urban area“ and “vacation building“, and as well as a clarification of what values the Swedish state intends to protect. In conclusion, the paragraph is applied today at the county governments and municipalities with a great support of a GIS-map and other previous errands. However, neither the county governments or the municipalities seems to have a totally clear picture regarding what values that are supposed to be protected and can therefore not be completely sure about where the geographical delimitation should be. But the geographical delimitations do not seem to be the greatest problem about the 4:4 Environmental Code, but definitions of expressions for instance “urban area“ and “vacation building “, and which values that the legislature aims to preserve.
Al-Dawoodi, M. T. S. « The synthesis and properties of some 4'-phenylazo 4-aminoazobenzenes ». Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371465.
Texte intégralCenter, University of Arizona Water Resources Research. « Arizona Water Resource Vol. 4 No. 4 (April-May 1995) ». Water Resources Research Center, College of Agriculture, University of Arizona (Tucson, AZ), 1995. http://hdl.handle.net/10150/316498.
Texte intégralTembo, Norbert Olivier. « Synthèse et étude physicochimique des 4-amino-1, 2, 3, 4-tétrahydro-1-isoquinolones et 2-quinolones ; 4-aryl-2, 3-dihydropyrrolizines ; 4-aryl-1-oxo-1, 2, 3, 4-tétrahydro-pyrrolo [1, 2-a] pyrazines ; 4-aryl-2-imidazolidinones ». Caen, 1990. http://www.theses.fr/1990CAEN4044.
Texte intégralViselgė, Vita. « Galimybė Nr.4 ». Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130805_102700-69467.
Texte intégralGamarra, Palacios Guillermo Leonardo, Tello Charles André Grados et Falcón Marco Seclén. « DRESS 4 LESS ». Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/624935.
Texte intégralTrabajo de investigación
Sousa, Cláudia Sofia Gonçalves Vinhas de. « Finance 4 All ». Master's thesis, Instituto Superior de Economia e Gestão, 2015. http://hdl.handle.net/10400.5/10876.
Texte intégralO projecto Finance4All consiste na criação de materiais pedagógicos que fomentem a literacia financeira. Nesse sentido, foi desenvolvido o jogo de cartas Deal Widit inserido na temática de literacia financeira e aprendizagem baseada em jogos. Optou-se por um jogo de cartas, uma alternativa eficaz e com custos muito reduzidos em comparação com outros tipos de jogos. O jogo tem como base a compra de negócios com elementos de risco e recompensa, poupança, orçamentação e estratégia. Também tem uma componente de figuras corporativas que enriquecerão o valor da empresa. O jogo, ainda na fase de protótipo, foi testado num pequeno grupo do qual se obteve feedback, pretendendo atingir o público em geral acima dos 12 anos.
There are many studies that prove that playing games is often better than conventional methods for learning. Playing helps not only to develop knowledge on the theme but also the improvement of soft skills such as problem solving, strategic thinking or perseverance. The main idea of the project was to create a game that spiked the interest on the financial topic. A card based game with a playing board was chosen. The lack of financial literacy, a problem for all age groups, can be tackled by small incentives such as playing a related game. This project is an attempt to make finance in general fun and easy – saving, investing, risk and return and another concepts are very much the main part of the game. The prototype game was tested in a small group several times and got a positive response. As a future objective the prototype should be finished and proceed its development stage with more testing, packing and distribution.
Sutinen, S. (Simo). « Prolyyli-4-hydroksylaasit ». Bachelor's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201702101164.
Texte intégralKemppainen, Tuula. « Årsta 4-9 ». Thesis, KTH, Arkitektur, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-208519.
Texte intégralAn elementary school for children aged 4 to 9 in the suburb Årsta in Stockholm. The school is located adjacent to a new residental area surrounding Årstafältet. The school will cater to around 500 students and a sport centre which will be available to the public. The program is divided into two volumes, where the sports centre is placed as the endpoint to an activitypath stretching across Årstafältet. The school is constructed with a wooden frame with adobe features, and interiorly exposed wood and earth. Three massive rammed earth walls mark the students abiding-places. Each class has its own abiding-place constituted by cloakroom, homeroom and a group activity room, which is intended to work as a safe base point throughout the school day. Workspaces and community spaces are designed to meet different preferences and social contexts. The shared workspaces consists of sociofugal spaces ment for separating the students from each other, while centered sociopatal spaces bring students together.
Scott, Keith A. « 4 urban houses ». Thesis, Virginia Tech, 1994. http://hdl.handle.net/10919/41385.
Texte intégralBodenham, Dean. « Exotic 4-manifolds ». Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/4865.
Texte intégralBrandt, Shawn Patrick. « Chamber Essay #4 ». University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1383913640.
Texte intégralSandoval, Francia William Junniors, Ocola Zait Deyanira Quenaya, Chirinos Yenny Paola Montenegro et Simón Nely Basilio. « ABC Service 4 ». Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/621983.
Texte intégralHollick, Jonathan J. « Pyran-4-one, thiopyran-4-one and 4-pyridone inhibitors of the phosphatidylinositol 3-kinase-related kinase family ». Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402415.
Texte intégralLeopold, Samuel Harris. « Photogeneration of Aryloxenium Ions : Photolysis of 4-acetoxy-4-(4'-methylphenyl)-2,5-cyclohexadienone in Acetonitrile as a Precursor ». Miami University Honors Theses / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1210088217.
Texte intégralPrie, Gildas. « Utilisation du 4, 4, 4-Trifluorobutynoate d'éthyle en synthèse organique : application à la synthèse de nouveaux rétinoïdes trifluorométhylés ». Tours, 2000. http://www.theses.fr/2000TOUR4034.
Texte intégralNilsson, Mary Francis. « Characterisation of proteinase-activated receptor-4 (PAR-4) signalling in NCTC-2544 cells stably expressing PAR-4 (Clone 10H9) and PAR-4 expressing cells, EAhy-926 ». Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=12777.
Texte intégralDuret, Guillaume. « Synthèse de 4-aminopyridines par réaction de cycloaddition (4+2) d’ynamides ». Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF012/document.
Texte intégralPyridine scaffolds are very interesting building blocks in various fields, they appear in various drugs, and are relevant either in agrochemistry, marials chemistry, polymers and in organic chemistry. Many efficient and direct methods to access polysubstituted pyridine scaffolds are described in the litterature, amongst these, the fused aminopyridines caught our attention. Indeed, there are only few reports in the litterature of such scaffold
Koppehele, Albina. « Synthese und Funktionalisierung von Calix[4]resorcin- und Calix[4]pyrogallolarenen ». Dresden TUDpress, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2674340&prov=M&dok_var=1&dok_ext=htm.
Texte intégralDias, Rafael Mafra de Paula. « Síntese e avaliação biológica de derivados 4-aminoquinolínicos e 4-mercaptoquinolínicos ». Universidade Federal de Juiz de Fora (UFJF), 2011. https://repositorio.ufjf.br/jspui/handle/ufjf/4296.
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Este trabalho intitulado Síntese e Avaliação Biológica de Derivados 4-Aminoquinolínicos e 4-Mercaptoquinolínicos está dividido em duas partes e descreve a síntese de compostos quinolínicos acoplados a moléculas e/ou compostos heterocíclicos com atividade biológica. A primeira parte que trata da obtenção de derivados 4-aminoquinolínicos, apresenta a síntese de 20 substâncias no qual acoplou-se derivados de sulfanilamida, isoniazida e ácido 4-aminosalicílico ao núcleo quinolínico. A segunda parte trata da obtenção de derivados 4-mercaptoquinolínicos visando a obtenção de 12 substâncias acoplando o núcleo quinolínico a outros heterocíclicos (2-mercaptobenzotiazol e 4-mercaptopiridina). Das 32 substâncias obtidas, 11 são inéditas e todas foram devidamente caracterizadas por técnicas espectroscópicas. Submeteram-se estas à avaliação biológica em parasitas causadores da Leishmaniose e em bactérias patogênicas Gram-positivas e Gram-negativas, bem como testes de citotoxicidade. Considerando as 15 substâncias testadas, 13 não se mostraram citotóxicas nas concentrações avaliadas e 11 apresentaram alguma atividade biológica, seja em promastigotas do gênero Leishmania ou em bactérias patogênicas.
This work entitled Synthesis and Biological Evaluation of 4-Aminoquinolines and 4-Mercaptoquinolines Derivatives is divided in two parts and describes the synthesis of quinolinic compounds coupled to molecules and / or heterocyclic compounds with biological activity. The first part deals with obtaining of 4-aminoquinolines derivatives. It presents the synthesis of 20 substances made by the coupling of sulfanilamide, isoniazid and 4-aminosalicylic acid derivatives to the quinolinic nucleus. The second part deals with obtaining of 4-mercaptoquinolines derivatives to obtain 12 substances with the quinolinic nucleus coupled to other heterocyclic (2-mercaptobenzothiazole and 4-mercaptopyridine). Of the 32 substances synthesized, 11 are new and all were properly characterized by spectroscopic techniques. The compounds were submitted to the biological evaluation against parasites that cause leishmaniasis and pathogenic Gram-positive and Gram-negative bacteria, as well as cytotoxicity tests. Considering the 15 substances tested, 13 were not cytotoxic at the concentrations evaluated, and 11 showed some biological activity, either in promastigotes of the Leishmania genus or pathogenic bacteria.
Matschonat, Gunda. « Zur NH 4 + -Sorption und NH 4 + -Fixierung in europäischen Waldböden / ». Bayreuth : BITÖK, 1995. http://www.gbv.de/dms/bs/toc/191522597.pdf.
Texte intégralKislyak, Anastasia. « In-depth kinetic understanding and design of [4+4] anthracene photocycloadditions ». Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/226945/1/Anastasia_Kislyak_Thesis.pdf.
Texte intégralWebb, Gordon A. « Radiopharmaceutical applications of technetium 3-oxy-4-pyrones and 3-oxy-4-pyridinones and gallium 3-oxy-4-pyridinones ». Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29206.
Texte intégralScience, Faculty of
Chemistry, Department of
Graduate
Stern, Eric. « Nouveaux agonistes des récepteurs aux cannabinoïdes CB², dérivés de 4-oxo-quinoléines, 4-oxo-naphtyridines et 4-oxo-cinnolines ». Lille 2, 2006. http://www.theses.fr/2006LIL2S013.
Texte intégralCancer, second cause of mortality nad morbidity in the developed countries, just after cardiovascular diseases, results from a deregulation of the genetic cell program leading to its immortality and its uncontroled proliferation. In France in 2004, about 40,000 new cases of prostate cancer were diagnosed. Prostate cancer reaches in general old people and represents the second cause of death per cancer, after lung cancer. Because of the ageing of the population of developed countries, the number of prostate cancer patients will increase. In order to solve problems related to the use of traditional anti-cancer drugs (lack of selectivity, resistance. . . ), the development of new therapeutic strategies to treat prostate cancer proves to be essential. Since 1997, Δ9-THC ( Δ9 – tétrahydrocannabinol, the major psychoactive component of Cannabis sativa L. ) is currently used to treat nausea and emesis in cancer patient undergoing extensive chemotherapy. Moreover some cannabis-based drugs are in phase three clinical trials for treating pain associated with cancer. Since Δ9-THC characterization in the sixties, many improvements have been made in cannabinoid pharmacology knowledge, particularly, in the nineties with the discovery of two G-protein coupled receptors : the CB1 receptor, which is mainly located in the central nervous system (CNS), and the CB2 receptor which is principally present in the immune system. Thanks to the development of a great variety of new synthetic ligands, the study of these receptors has revealed the anticancer potency of the cannabinoid receptors agonists. CB1 receptor stimulation could induce undesirable effects due to its CNS localization, so we proposed to study the anticancer potency of CB2-selective agonists. In order to develop new potent CB2-selective ligands, a 98-compound library was built using a central heterocyclic ring as quinoleine, naphthyridine or cinnoline, substitued in position 3 by various carboxamido substituents, and hydrophobic side chains in the N1-position. Pharmacological results revealed a strong CB2 selectivity, and an agonist profile for all compounds. Thus, some chemical modulations were next realized as : replacement of the carboxamide link, in position 3, by inverse amide analogue or its reduction in secondary amine ; introduction of differentsubstituents on the position 2, 5, 6, 7 and 8 ; modulation of the N1-position side chain. Anticancer potency of these new potent CB2 receptor ligands was investigated using different prostate cancer cell lines
Tasso, Thiago Teixeira. « Síntese, caracterização e estudo das propriedades eletrônicas de heterocomplexos formados por 4, 4 , 4 , 4 , tetrassulfoftalocianina de cobalto (II) e tetrakis(N-metil-4- piridil)porfirina de cobalto (II) e formação de filmes Layer-by- Layer ». Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/6483.
Texte intégralUniversidade Federal de Sao Carlos
This work reports the synthesis, characterization and investigation of the electronic properties of heterocomplexes formed by cobalt(II) tetrakis(N-methyl-4- pyridyl)porphyrin (CoTMPyP) and cobalt(II) 4, 4 , 4 , 4 , tetrasulfophtalocyanine (CoTsPc) in solution and thin films. Spectroscopic titrations were performed using solutions of the CoTsPc and CoTMPyP macrocycles, and the heteroaggregates stoichiometries were investigated using Job s method. The Job s plots pointed to the formation of supramolecular arrays containing higher proportions of CoTsPc. It was possible, for the first time, to isolate species formed in solution by changing the medium s dielectric constant. After characterization of the isolated species, it was verified that, despite the different stoichiometries, only one heterocomplex was formed, composed by two molecules of CoTsPc in terminal positions and one CoTMPyP molecule. The triad was characterized by mass spectrometry and UV-vis and i.v. absorption spectroscopy. Strong interactions between the charged substituent groups of the CoTsPc and CoTMPyP macrocycles were observed, in addition to the significant changes on the macrocycles electronic levels, due to the coupling of the electronic densities in the face-to-face array. Thin films containing the precursor macrocycles and the triad were grown using the Layer-by-Layer (LbL) technique. LbL films of CoTsPc with poly(allylamine hydrochloride) (PAH) polymer and CoTMPyP with poly(styrenesulfonate) (PSS) polymer were grown up to 30 bilayers. The CoTsPc and CoTMPyP macrocycles, in the mixed LbL films, behave independently, without formation of heteroaggregates during bilayers deposition. Triad s LbL films, using PAH as polyelectrolyte, were also obtained up to 15 bilayers. Cyclic voltammetry measurements of the LbL films demonstrated the coupling of the macrocycles electronic densities in the triad, through changes in the redox potential of both rings and metallic centers.
Neste trabalho relatam-se as etapas de síntese, caracterização e estudo das propriedades eletrônicas de heterocomplexos formados por tetrakis(N-metil-4- piridil)porfirina de cobalto (II) (CoTMPyP) e 4, 4 , 4 , 4 , tetrassulfoftalocianina de cobalto (II) (CoTsPc) em solução e em filmes finos. Foram realizadas titulações espectroscópicas utilizando-se soluções dos macrociclos CoTsPc e CoTMPyP e, através do método de Job foram investigadas as possíveis estequiometrias dos heteroagregagos. Os gráficos de Job apontaram para formação de arranjos supramoleculares com maior proporção de CoTsPc. Utilizando-se as estequiometrias determinadas pelo método de Job, foi possível isolar, pela primeira vez, as espécies formadas em solução através da mudança da constante dielétrica do meio. Após caracterização das espécies isoladas, verificou-se que, apesar das diferentes estequiometrias, ocorreu a formação de somente um heterocomplexo, formado por duas moléculas de CoTsPc em posições terminais e uma de CoTMPyP central. A tríade foi caracterizada por medidas de espectrometria de massas e espectroscopia de absorção na região do i.v. e UV-vis. Observou-se uma forte interação entre os grupos substituintes carregados dos macrociclos CoTsPc e CoTMPyP, além de significativa alteração dos níveis eletrônicos dos anéis macrocíclicos, devido ao acoplamento das densidades eletrônicas no arranjo face-a-face. Filmes finos contendo os macrociclos precursores e a tríade foram preparados a partir da técnica Layer-by-Layer (LbL). Filmes LbL utilizando-se CoTsPc com hidrocloreto de polialilamina (PAH) e CoTMPyP com poliestirenossulfonato (PSS) foram depositados com boa linearidade até 30 bicamadas. Os macrociclos CoTsPc e CoTMPyP nos filmes LbL mistos comportam-se de maneira independente, não havendo a formação de heteroagregados durante a deposição das bicamadas. Foram também obtidos filmes LbL utilizando-se a tríade e PAH como polieletrólitos até 15 bicamadas. Medidas de voltametria cíclica dos filmes LbL demonstraram o acoplamento das densidades eletrônicas dos macrociclos na tríade, através da mudança dos potenciais redox dos anéis e do centro metálico.
Wintrich, Klaus. « Schädigungsverhalten der einkristallinen Superlegierung CMSX-4 bei Hochtemperaturbelastung ». [S.l. : s.n.], 2004. http://elib.tu-darmstadt.de/diss/000446.
Texte intégralWilhelmsson, Natalie. « Samverkan 4 U : En studie om samverkan med organisationen Here 4 U ». Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-23678.
Texte intégralSyftet med föreliggande studie var att undersöka betydelsen för och effekterna av samverkan mellan elevorganisationen Here 4 U och dess partners. Utgångspunkten var en enkät som sändes till berörda handledare, rektorer och andra samverkanspartners. De mest framträdande kvantitativa resultaten från enkäten relaterades till tidigare forskning om nyinstitutionell organisationsteori och empowerment. Det visade sig att de som samverkar med Here 4 U ansåg samarbetet vara nödvändigt och att de ville fortsätta med det i framtiden. Respondenterna hade ombetts definiera samverkansbegreppet. De faktorer som genomgående lyftes fram var gemenskap, trygghet och gemensamma mål. Effekterna av samverkan sades ha positiv effekt på de berörda ungdomarna och bedömdes ha förbättrats med samverkan. En samordnare från Here 4 U ombads därefter kommentera resultaten i en intervju. Slutsatsen blir att samtliga samverkanspartners var nöjda med samverkan med Here 4 U, inte bara för sin egen skull, utan också med tanke på de positiva effekterna i arbetet med och för ungdomar.
Tsoi, Lai-shan, et 蔡麗珊. « Tumor suppressive functions of Krüppel-like factor 4 (KLF 4) in neuroblastoma ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hdl.handle.net/10722/208425.
Texte intégralpublished_or_final_version
Surgery
Master
Master of Philosophy
Davies, Alexandra Katherine. « An investigation of the function of adaptor protein complex 4 (AP-4) ». Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289777.
Texte intégralFrick, Eduard [Verfasser], et Michael [Akademischer Betreuer] Müller. « Funktionelle und strukturelle Charakterisierung von 4-Hydroxyphenylpyruvat Dioxygenasen und 4-Hydroxymandelat Synthasen ». Freiburg : Universität, 2014. http://d-nb.info/1115495623/34.
Texte intégral