Articles de revues : « 812/.54 »

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Goodrick, I., et P. N. Nelson. « Mineralisation of soil organic carbon in two Andisols under oil palm : an incubation study into controlling factors ». Soil Research 56, n^o 1 (2018) : 105. http://dx.doi.org/10.1071/sr16089.

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Understanding the factors controlling stability against mineralisation of soil organic matter is important for predicting changes in carbon stocks under changed environment or management. Soil carbon dynamics in oil palm plantations are little studied and have some characteristics that are unusual compared with other agricultural soils, such as high management-induced spatial variability and warm moist conditions. The aim of this work was to determine the factors controlling the mineralisability of the intermediate-stability carbon fraction of volcanic ash surface soils (0–5 and 15–20 cm depth) from oil palm plantations in Papua New Guinea. Soils with carbon contents of 2.2–35.2%, from areas with low and high organic matter inputs, were incubated for up to 812 days and soil respiration was measured periodically. Mean carbon turnover rates were 0.18–1.58, 0.07–0.23 and 0.03–0.07 a–1 on Days 54, 379 and 812 respectively. Turnover rate was initially (Day 54) correlated with pre-incubation total carbon content (r = 0.88), the ratio of permanganate-oxidisable carbon to total carbon (r = 0.62) and the ratio of oxalate-extractable Al and Fe to total carbon (r = –0.51 and –0.54 respectively), but the correlations decreased with time, being insignificant on Day 812. In the soils that had changed from C4 grassland 25 years previously, turnover rate was negatively correlated with δ13C, which increased with depth, but δ13C did not change significantly over the course of the incubation. Temperature sensitivity of mineralisation varied little, despite large differences in soil properties and changes in mineralisation rate. This suggested that turnover rates were affected to similar extents by biochemical recalcitrance and physical protection, as these two factors influence temperature sensitivity in opposing directions. Physico-chemical protection of organic matter appeared largely related to interaction with poorly crystalline Al and Fe oxides.

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赵, 美霞, 嵘. 王, 天然陈, J. Price Gilbert, 祺. 施, 建新赵, 淑. 李, 克服余 et 特固陈. « 大亚湾石珊瑚群落近25年的变化及其对2008年极端低温事件的响应 ». Chinese Science Bulletin 54, n^o 6 (1 mars 2009) : 812–20. http://dx.doi.org/10.1360/csb2009-54-6-812.

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Janis, Mark W. « International Human Rights. By Frank Newman and David Weissbrodt. (Cincinnati : Anderson Publishing Co., 1990. Pp. xxiv, 812. Index. Handbook included. $54.) ». American Journal of International Law 87, n^o 1 (janvier 1993) : 196. http://dx.doi.org/10.2307/2203881.

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Vigren, E., M. Galand, A. I. Eriksson, N. J. T. Edberg, E. Odelstad et S. J. Schwartz. « ON THE ELECTRON-TO-NEUTRAL NUMBER DENSITY RATIO IN THE COMA OF COMET 67P/CHURYUMOV–GERASIMENKO : GUIDING EXPRESSION AND SOURCES FOR DEVIATIONS ». Astrophysical Journal 812, n^o 1 (8 octobre 2015) : 54. http://dx.doi.org/10.1088/0004-637x/812/1/54.

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Demirel, A., et S. Suma. « The Efficacy of Non-Contrast Helical Computed Tomography in the Prediction of Urinary Stone Composition In Vivo ». Journal of International Medical Research 31, n^o 1 (février 2003) : 1–5. http://dx.doi.org/10.1177/147323000303100101.

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The composition of urinary stones was predicted on the basis of the differences in their Hounsfield unit (HU) densities as detected by in vivo non-contrast helical computed tomography (NCHCT). A total of 87 stones, which had been obtained from patients admitted to the emergency department with acute flank pain, were analysed biochemically. These stones had been visualized by NCHCT before spontaneous passage, ureteroscopic extraction or surgical removal, and their HU densities had been recorded. The HU densities of the stones were compared with the results of biochemical analysis. The mean HU densities of the stones composed of calcium oxalate ( n = 54), struvite ( n = 19) and uric acid ( n = 14) were 812 ± 135, 614 ± 121 and 413 ± 143, respectively. The differences between the mean HU densities of these three stone types were statistically significant. This initial clinical study demonstrated that in vivo NCHCT analysis may be used to predict the composition of urinary stones.

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Amarasena, N., N. Ikeda, K. K. S. Win, Y. Yamaguchi, T. Takehara et H. Miyazaki. « Factors Associated with Severe Periodontitis in Rural Cambodia ». Asia Pacific Journal of Public Health 16, n^o 1 (janvier 2004) : 50–53. http://dx.doi.org/10.1177/101053950401600109.

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An analytical cross-sectional study was conducted with 812 subjects aged 35-74 years in Prek Russey commune, Cambodia to detect some factors associated with severe periodontitis. Four calibrated examiners employed Community Periodontal Index (CPI) to ascertain periodontal pocket depth (PD) and loss of epithelial attachment (LA). A questionnaire was used to obtain tobacco and alcohol consumption habits. One hundred (12.3%) subjects had one or more sextants with ≥ 4mm PD and ≥ 6mm LA (severe periodontitis). Smoking, tobacco chewing and age were significantly associated with severe periodontitis in bivariate analysis while only age and quantified smoking remained significant in a logistic regression analysis. The impact of quantified smoking on severe periodontitis was almost negligible [OR: 1.0006 (95% CI: 1.0001, 1.001)] compared to that of age [OR ranged from 8.3 at 45-54 years to 22 at 65-74 years (95% CI: 3.1, 62.3)]. Nevertheless, both age and quantified smoking can be considered as factors associated with severe periodontitis in rural Cambodians. Asia Pac J Public Health 2004; 16(1): 50-53.

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Yu, Qing, Jianfeng Gu et Weimin Ye. « Deladenus prorsus n. sp. (Nematoda : Neotylenchidae) in dunnage wood from Malaysia intercepted in Ningbo, China ». Nematology 15, n^o 4 (2013) : 379–88. http://dx.doi.org/10.1163/15685411-00002683.

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Deladenus prorsus n. sp., isolated from dunnage wood originating from Malaysia and intercepted in Ningbo port, P.R. China, is described and illustrated. The dunnage wood material appeared to have holes resembling the typical exit holes of wood-boring insects and have associated blue stain. The new species is characterised by the presence of both the mycophagous and infective forms (Deladenus consists of mycetophagous-only forms and those with known female dimorphism), the body length of 814 (670-1147) and 898 (812-979) μm for mycetophagous males and females, respectively, and 1129 (1114-1352) μm for the infective female, and by the very anterior position of the excretory pore which is situated at 30.7 (24.4-33.0), 30.6 (25.4-35.6) and 37.9 (27.3-39.7) μm for the mycetophagous males and females and infective females, respectively, and the distance that the excretory pore is located anterior to the hemizonid which is 82 (77-90), 74 (54-92) and 86 (64-106) μm for the mycetophagous males and females and infective females, respectively. The diagnostic value of the excretory pore and the hemizonid of the species of the genus are discussed. The ribosomal DNA ITS region was sequenced and analysed.

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Fırat Durdukoca, Şule. « Okul Dışı Öğrenme Üzerine Eğitim Araştırmalarının Bibliyometrik Analizi ». MANAS Sosyal Araştırmalar Dergisi 13, n^o 3 (25 juin 2024) : 940–55. http://dx.doi.org/10.33206/mjss.1288622.

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Okul çağındaki öğrenciler günlük yaşamlarının yaklaşık üçte ikisini formal eğitim dışında geçirmektedirler. 21. yüzyılda değişen bilgi paradigmasına bağlı olarak öğrenenlerin öğrenme ortamları, öğretim programlarının faaliyet alanları formal eğitimin ötesine çıkmakta; öğrencilerin okul dışındaki deneyimleri, bilgi edinme süreçleri, tutumları, inançları ve bu değişkenlerin davranışları üzerindeki etkileri okuldaki öğrenme süreçleri kadar önemsenmekte ve eğitim araştırmalarına konu olmaktadır. Bu araştırmada Web of Science (WoS) veri tabanında eğitim araştırmaları kategorisinde yer alan okul dışı öğrenme konusunda yayınlanmış makalelerin bibliyometrik değerlendirmesi yapılarak bu alandaki eğilimlerin ortaya konulması amaçlanmıştır. Araştırmada bibliyometrik analiz yöntemi kullanılmış, veriler 14.04.2023 tarihinde WoS veri tabanından alınmıştır. Veri tabanında okul dışı öğrenme konusunda 1267 adet çalışmaya ulaşılmış, Eğitim/Eğitim Araştırmaları kategorisindeki 812 makaleye ait veri, araştırmanın veri setini oluşturmuştur. Araştırma sonucunda; okul dışı öğrenme konusu ilk makalenin 1971 yılında, en fazla sayıda makalenin ise 2018 yılında yayınlandığı, 2006 yılından itibaren yayınlanan makalelere yapılan atıfların sayısında ciddi artışlar olduğu belirlenmiştir. En fazla sayıda atıf alan makale Computers & Education dergisinde yayınlanmıştır. Konu alanıyla ilgili literatüre katkı sağlayan 54 farklı ülkeden 1434 yazara ulaşılmıştır. İncelenen makalelerde 377 ortak anahtar kelime olduğu, sıklıkla ortak atıf alan yazarların birbirlerine yakın yayın sayılarıyla konu alanı ile ilgili literatüre en fazla katkı sağlayan yazarlar olduğu belirlenmiştir.

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Xu, Xiaoyu, Si Shan, Wenlei Wang et Hongning Liu. « Analysis of the Components in Moxa Smoke by GC-MS and Preliminary Discussion on Its Toxicity and Side Effects ». Evidence-Based Complementary and Alternative Medicine 2020 (31 octobre 2020) : 1–13. http://dx.doi.org/10.1155/2020/2648759.

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Moxibustion plays an important role in the prevention and treatment of diseases and the promotion of human health. In this study, the components in moxa smoke from Jiangxi Poai Biotechnology Co., Ltd., namely, Qing moxa sticks, were absorbed by five solvents (cyclohexane, ethyl acetate, n-butanol, anhydrous ethanol, and water) and identified by gas chromatography-mass spectrometry. The identification results of the smoke from the Qing moxa sticks that was absorbed in liquid are as follows: a total of 294 compounds were identified, including 139 in cyclohexane, 145 in ethyl acetate, 60 in n-butanol, 89 in anhydrous ethanol, and 77 in water, and of those, 112 toxic compounds were identified. Furthermore, Ingenuity Pathway Analysis software and the PubChem database were successfully applied to analyze the toxic compounds. There were 812 target proteins related to the toxic components, 25 molecular networks, and 54 biological pathways. The results showed that the toxic compounds of moxa smoke may have some side effects on the heart, liver, and kidney of humans. This study revealed that the components of moxa smoke are complex and diverse. Due to the findings of toxic compounds in moxa smoke, we recommend that moxibustion rooms should be equipped with ventilation equipment or enough artificial ventilation to ensure the health of patients and practitioners.

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Ushida, Yuta, Eiji Shinozaki, Keisho Chin, Mitsukuni Suenaga, Daisuke Takahari, Masato Ozaka, Mariko Ogura et al. « Clinical outcomes of anti-EGFR antibody treatment for right-sided colon cancer patients without RAS, BRAF, and PIK3CA mutations in the later line. » Journal of Clinical Oncology 36, n^o 4_suppl (1 février 2018) : 812. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.812.

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812 Background: Several studies have reported that patients with right-sided colon cancers (RCC) have more unfavorable responses to anti-epidermal growth factor receptor (EGFR) antibody therapy than those with left-sided colon cancers (LCC). One of the causes is that RCC have more frequently genetic mutations such as RAS, BRAF, and PIK3CA than LCC. We investigated clinical outcomes of RCC patients treated with anti-EGFR antibody in the later line without these mutations. Methods: We reviewed 653 cases of colorectal cancer treated with anti-EGFR antibody from October 2009 to July 2017. There were 150 cases of RCC patients. Among them, 32 patients without KRAS status and 54 patients without enough genetic samples for gene re-analysis were excluded. We extracted 64 patients with status on RAS, BRAF, and PIK3CA , and finally enrolled 25 patients treated with anti-EGFR antibody plus irinotecan or anti-EGFR antibody alone in the later line. We analyzed the relationship of molecular status with clinical outcomes; overall response rate (RR), overall survival (OS) and progression-free survival (PFS) in this retrospective study. Results: Overall, there were 48% of cases with any mutations; among them 8.0% for KRAS, 4.0% for NRAS, 24.0% for BRAF and 4.0% for PIK3CA. Twenty percent of patients were treated as 2nd line therapy, while 72%, 16% treated as 3rd, 4th line therapy. RR of all cases, those whom without KRAS, RAS, RAS or BRAF, any mutations were 16.0%, 19.1%, 20.0%, 28.6%, 30.8%. The median OS and PFS in all wild-type patients were tended to be better than in those of all cases (OS; 14.9 vs. 11.6 months, hazard ratio = 0.70, p = 0.30, PFS; 8.17 vs. 5.37 months, hazard ratio = 0.67, p = 0.24). Conclusions: Even if primary tumors are in right-sided colon, in the enriched and selected patients anti-EGFR antibody therapy showed enough antitumor activity. Anti-EGFR antibody for RCC cases without using it at the front line is an effective option in the later line.

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Pohlmann, Dominika, Martin Berlin, Felix Reidl, Steffen Emil Künzel, Uwe Pleyer, Antonia M. Joussen et Sibylle Winterhalter. « Longitudinal Comparison of Constant Artifacts in Optical Coherence Tomography Angiography in Patients with Posterior Uveitis Compared to Healthy Subjects ». Journal of Clinical Medicine 11, n^o 18 (13 septembre 2022) : 5376. http://dx.doi.org/10.3390/jcm11185376.

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Background: Knowledge about artifacts in optical coherence tomography angiography (OCTA) is important to avoid misinterpretations. An overview of possible artifacts in posterior uveitis provides important information for interpretations. Methods: In this monocentric prospective study, OCTA images from a total of 102 eyes of 54 patients with posterior uveitis, and an age-matched control group including 34 healthy subjects (67 eyes), were evaluated (day 0, month 3, month 6). We assigned different artifacts to distinct layers. Various types of artifacts were examined in different retinal layers. The χ2 test for the comparison between the control and uveitis group and Cochran’s Q test for the longitudinal comparison within the uveitis group were used. Results: A total of 2238 images were evaluated; 1836 from uveitis patients and 402 from healthy subjects. A total of 2193 artifacts were revealed. Projection (812 [36.3%]), segmentation (579 [25.9%]), shadowing (404 [18.1%]), and blink artifacts (297 [13.3%]) were the most common artifact types. The uveitis group displayed significantly more segmentation artifacts and projection artifacts (p < 0.001). No segmentation artifacts were documented in healthy subjects. The consecutive examinations within the uveitis group revealed the same artifact types without significance (p > 0.1). Conclusions: The uveitis patients showed more segmentation and projection artifacts than the control group. Within the uveitis group, artifacts remained longitudinally constant in terms of artifact type and pattern. The artifacts therefore appear to be reproducible on an individual level.

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Rubio Cobarruvias, Oswaldo Ángel, et Mateo Armando Cadena Hinojosa. « Optimización del fraccionamiento del nitrógeno en el cultivo de papa en el Valle de Toluca ». Revista Mexicana de Ciencias Agrícolas 3, n^o 6 (21 juin 2018) : 1075–84. http://dx.doi.org/10.29312/remexca.v3i6.1360.

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La forma más conveniente de fraccionar el fertilizante nitrogenado varía de acuerdo al tipo de suelo, manejo del cultivo y a las condiciones climáticas. El objetivo del presente trabajo fue determinar la mejor forma de fraccionar el nitrógeno en el cultivo de papa en el Valle de Toluca, bajo condiciones de temporal. En 2006 se estableció un experimento en el que se probaron tres dosis de nitrógeno (100, 200 y 300 kg N ha-1) fraccionadas en 1, 2 y 4 partes que se aplicaron a la siembra, 18, 34 y 47 días después de la emergencia de las plantas (DDE). Además se incluyó un tratamiento sin nitrógeno. Durante el ciclo vegetativo del cultivo se hicieron cuatro determinaciones de la concentración de nitrato en el extracto celular de los pecíolos foliares (ECP) a los 25, 40, 54 y 68 DDE, para ello se usó un medidor CARDY. Los máximos rendimientos de 42.4 y 42.1 t ha-1 se obtuvieron con 200 kg N ha-1 cuando el nitrógeno se fraccionó en una o dos partes respectivamente. La concentración de nitrato en el ECP a los 25 DDE asociada con los máximos rendimientos fue de 1 818 y 1 812 mg L-1 de N-NO3 respectivamente. Los análisis de nitratos en el ECP indicaron que al fraccionar en cuatro partes el nitrógeno, se propiciaron def iciencias de este elemento durante las primeras etapas de desarrollo de las plantas que y las aplicaciones tardías ocasionaron alteraciones fisiológicas en detrimento de la producción de tubérculos.

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More O'Ferrall, G. J., et M. G. Keane. « A comparison for live weight and carcass production of Charolais, Hereford and Friesian steer progeny from Friesian cows finished on two energy levels and serially slaughtered ». Animal Science 50, n^o 1 (février 1990) : 19–28. http://dx.doi.org/10.1017/s0003356100004438.

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ABSTRACTOne hundred and sixty-two spring born steers comprising 54 Charolais × Friesian (CH), 54 Hereford × Friesian (HE) and 54 Friesians (FR) were reared together from shortly after birth until the end of their second grazing season at a mean age of 573 days. The animals were then blocked on weight within genotype, housed in a slatted shed and allocated to either a high (12·6 MJ metabolizable energy (ME) per kg) or a medium (10·4 MJ ME per kg) energy diet offered ad libitum until slaughter at one of three target carcass weights · light (260 kg (HE, FR and CH)), normal (300 kg (HE and FR) and 320 kg (CH)) or heavy (340 kg (HE and FR) and 380 kg (CH)) to give a 3 (breed type) · 2 (energy level) · 3 (slaughter weight) factorial arrangement during the finishing winter. The trial was repeated in 3 years consecutively.CH were significantly heavier than HE at all times up to 18 months of age when they were 43 kg heavier, at which stage they were also 24 kg heavier than FR. CH grew significantly faster at pasture than HE in both seasons and faster than FR in the second season. HE had the best daily gain in the finishing period.Overall slaughter weights per day of age, carcass weights per day of age and carcass weights of CH, HE and FR were 812, 771 and 761 (s.e. 9·2) g, 448, 418 and 405 (s.e. 4·8) g and 318. 299 and 298 (s.e. 2·2) kg, respectively. CH had significantly better killing-out proportions (lOg/kg) than HE which in turn were 10 g/kg better than FR. CH and FR had similar carcass length, carcass depth, leg length and leg widths and both were significantly larger than HE. CH had significantly larger longissimus dorsi areas than either HE or FR (80·9 v. 67·0 and 66·4 cm-); they also had significantly better conformation scores than HE which in turn were significantly better than FR.Increasing the energy level during the finishing period increased daily gain by proportionately 0·52 (1089 v. 684 g/day), reduced slaughter age by 51 days (711 v. 762 days) and significantly increased killing-out proportion (551 v. 534 g/kg) and conformation score (4·86 v. 4·64). Offal as a proportion of empty live weight tended to be higher for FR than for HE or CH, the exception being the hide, which was significantly lower for FR.

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Thacher, Tom D., Christopher T. Sempos, Ramon A. Durazo-Arvizu, Philip R. Fischer, Craig F. Munns et John M. Pettifor. « The Validity of Serum Alkaline Phosphatase to Identify Nutritional Rickets in Nigerian Children on a Calcium-Deprived Diet ». Journal of Clinical Endocrinology & ; Metabolism 106, n^o 9 (13 mai 2021) : e3559-e3564. http://dx.doi.org/10.1210/clinem/dgab328.

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Abstract Context Nutritional rickets results from the interaction of low vitamin D status and limited calcium intake. Serum alkaline phosphatase (AP) activity is a biomarker of impaired mineralization in rickets. Objective To assess the performance of serum AP activity in identifying nutritional rickets in calcium-deprived Nigerian children. Methods We reanalyzed data from a case-control study of children with active rickets and matched control subjects without rickets, using a multivariate logistic regression to assess the odds of rickets associated with AP activity, adjusting for age, sex, and weight-for-age z-score. Results A total of 122 children with rickets and 119 controls were included. Rachitic children had a mean (±SD) age of 54 ± 29 months, and 55 (45.1%) were male. Cases and controls had low dietary calcium intakes (216 ± 87 and 214 ± 96 mg/day, respectively). Serum AP activity levels in cases and controls were 812 ± 415 and 245 ± 78 U/L, respectively (P < 0.001). AP was negatively associated with 25-hydroxyvitamin D values (r = −0.34; P < 0.001). In the adjusted model, the odds ratio (95% CI) receiver operating characteristic curve was 0.978. AP > 350 U/L identified nutritional rickets in Nigerian children with sensitivity 0.93, specificity 0.92, positive likelihood ratio 11.3, and negative likelihood ratio 0.07. Conclusion An AP > 350 U/L effectively discriminated between Nigerian children with and without nutritional rickets. AP is a low-cost biochemical test that could be used to screen for nutritional rickets, but cutoff values require validation in other populations, and laboratory values need to be standardized for widespread population studies.

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Schreuder, Anne, Klaske Booij, Philip de Reuver, Otto van Delden, Krijn van Lienden, Marc Besselink, Olivier Busch, Dirk Gouma, Erik Rauws et Thomas van Gulik. « Percutaneous-endoscopic rendezvous procedure for the management of bile duct injuries after cholecystectomy : short- and long-term outcomes ». Endoscopy 50, n^o 06 (19 janvier 2018) : 577–87. http://dx.doi.org/10.1055/s-0043-123935.

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Abstract Background Bile duct injury (BDI) remains a daunting complication of laparoscopic cholecystectomy. In patients with complex BDI, a percutaneous-endoscopic rendezvous procedure may be required to establish bile duct continuity. The aim of this study was to assess short- and long-term outcomes of the rendezvous procedure. Methods All consecutive patients with BDI referred to our tertiary referral center between 1995 and 2016 were analyzed. A rendezvous procedure was performed when endoscopic or radiologic intervention failed, and when deemed feasible by a dedicated multidisciplinary team including hepatopancreaticobiliary surgeons, gastrointestinal endoscopists, and interventional radiologists. Classification of BDI, technical success of the rendezvous procedure, procedure-related adverse events, and outcomes were assessed. Results Among a total of 812 patients, rendezvous was performed in 47 (6 %), 31 (66 %) of whom were diagnosed with complete transection of the bile duct (Amsterdam type D/Strasberg type E injury). The primary success rate of rendezvous was 94 % (44 /47 patients). Overall morbidity was 18 % (10 /55 procedures). No life-threatening adverse events or 90-day mortality occurred. After a median follow-up of 40 months (interquartile range 23 – 54 months), rendezvous was the final successful treatment in 26 /47 patients (55 %). In 14 /47 patients (30 %), rendezvous acted as a bridge to surgery, with hepaticojejunostomy being chosen either primarily or secondarily to treat refractory or relapsing stenosis. Conclusions In experienced hands, rendezvous was a safe procedure, with a long-term success rate of 55 %. When endoscopic or transhepatic interventions fail to restore bile duct continuity in patients with BDI, rendezvous should be considered, either as definitive treatment or as a bridge to elective surgery.

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Koneska, Elena, Duncan Appelbe, Paula R. Williamson et Susanna Dodd. « Usage Metrics of Web-Based Interventions Evaluated in Randomized Controlled Trials : Systematic Review ». Journal of Medical Internet Research 22, n^o 4 (16 avril 2020) : e15474. http://dx.doi.org/10.2196/15474.

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Background The evaluation of web-based interventions (defined as an intervention that can be downloaded or accessed on the internet through a web browser) in randomized controlled trials (RCTs) has increased over the past two decades. Little is known about how participants’ use of the intervention is measured, reported, and analyzed in these studies. Objective This study aimed to review the evaluation of web-based interventions in RCTs, assessing study characteristics and the methods used to record, and adjust for, intervention usage. Methods A systematic review of the literature was undertaken to identify all published reports of RCTs that involved a web-based intervention. A random sample of 100 published trials was selected for detailed data extraction. Information on trial characteristics was extracted, including whether web usage data were recorded, and if so, the methods used to gather these data and whether these data were used to inform efficacy analyses. Results A PubMed search identified 812 trials of web-based interventions published up to the end of 2017 and demonstrated a growing trend over time. Of the 100 studies reviewed, 90 studies collected web usage data, but more than half (49/90, 54%) of these studies did not state the method used for recording web usage. Only four studies attempted to check on the reliability of their web usage data collection methods. A total of 39% (35/90) studies reported patterns or levels of web intervention use, of which 21% (19/90) studies adjusted for intervention use in their outcome analysis, but only two of these used appropriate statistical methods. Conclusions Trialists frequently report a measure of web-based intervention usage but do not always report the collection method or provide enough detail on their analysis of web usage. Appropriate statistical methods to account for intervention use are rarely used and are not well reported even in the very few trials in which they are used. The number of trialists who attempt to check on the reliability of their web usage collection methods is extremely low.

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Oliveria, Susan A., Laura Chu, Deborah Casso, Karen Wells, Wei Dong, Robert Dubrow, Asha Das, David R. Nerenz et Marianne Ulcickas Yood. « Treatment patterns and comorbidities in a population-based cohort of glioblastoma patients diagnosed 1997-2008. » Journal of Clinical Oncology 30, n^o 15_suppl (20 mai 2012) : 1591. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1591.

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1591 Background: Glioblastoma multiforme (GBM) is one of the most common, most malignant and rapidly progressive forms of brain cancer. Published reports of GBM in non-trial populations are limited. The purpose of this study was to assemble a population-based cohort of GBM patients with comprehensive clinical and demographic information and to define treatment patterns and outcomes in this population. Methods: GBM patients served by Henry Ford Health System (HFHS), a major GBM referral center, were identified using ICD-O and histology codes from the HFHS tumor registry. Eligible patients were newly diagnosed with GBM between 1997 and 2008. Comprehensive, population-based data were compiled using tumor registry data (including histology and mortality) with linkages to pharmacy data (including infusion), outpatient and inpatient encounter data, and laboratory results. Results: Overall, 812 GBM patients were identified; mean age was 54 years (standard deviation 15.8). The cohort was 63% male and 84% white. Among the most common post-diagnosis comorbidities/complications, 14% of patients had venous thromboembolism (95% confidence interval [CI] 12-17), 16% had seizures (95% CI 14-19), and 6% had central nervous system hemorrhage (95% CI 4-7). Arterial thromboembolism occurred in 3% of patients (95% CI 2-4), while 7% experienced infections such as candidiasis, herpes simplex, and pneumocystis pneumonia (95% CI 5-9) and 2% experienced wound dehiscence (95% CI 1-3). 94% (95% CI 93-96) of the cohort received some form of treatment with 81% undergoing surgery (95% CI 78-84), 75% receiving radiation therapy (95% CI 72-78), and 67% receiving chemotherapy (95% CI 64-70). Median overall survival after diagnosis was 1.4 years (95% CI 1.3-1.5) among all patients, and 1.6 years (95% CI 1.4-2.0) among those diagnosed 2005-2008. Conclusions: This study presents a well-characterized population-based cohort of GBM patients. Understanding treatment patterns and comorbidities outside the clinical trial setting is important in informing and evaluating real-world treatment decisions. Additional results exploring time trends in systemic cancer therapy and Kaplan-Meier survival curves will be presented.

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Vetchinnikova, O. N. « Hyperparathyroidism in kidney transplant candidates and postoperative parathyroid gland function in recipients ». Russian Journal of Transplantology and Artificial Organs 26, n^o 2 (7 février 2024) : 82–93. http://dx.doi.org/10.15825/1995-1191-2024-2-82-93.

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Objective: to evaluate the effects of secondary hyperparathyroidism (HPT) in kidney transplantation (KT) candidates on recipients’ parathyroid gland function in the first postoperative year.Materials and methods. The retrospective cohort study included 210 patients (103 women, 107 men, age 45 ± 9 years) with stage 5 chronic kidney disease (stage 5 CKD, including dialysis-dependent patients), who had undergone cadaveric KT. Biochemical screening before kidney transplantation and in the postoperative period at 3 and 12 months determined serum levels of parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase activity, albumin and creatinine using standard methods. PTH levels of 130–595 pg/mL and ≤130 pg/mL were taken as the target level in the pre- and post-transplant periods, respectively.Results. Fifty-six KT candidates (group 1) had HPT and 154 (group 2) had the target PTH levels. PTH level was 897 (722; 1136) and 301 (229; 411) pg/mL, respectively, p < 0.001. PTH decreased in all recipients at 3 months after KT: by 595 (420; 812) in group 1 and 148 (77; 230) pg/ mL in group 2, p < 0.001, to 254 (180; 455) and 150 (118; 212) pg/mL, respectively, p < 0.001; the target level was detected in 10.7% and 42.2% of recipients, respectively, p < 0.001. At 12 months, blood PTH was 171 (94; 239) pg/mL in group 1 and 112 (90; 135) pg/mL in group 2, p = 0.004; target level was found in 48.2% and 73.4% of recipients, respectively, p < 0.001. Kidney graft function was identical in both recipient groups: acute tubular necrosis in 41.1% and 54.5%; at 3 months, median glomerular filtration rates (GFR) of 60 and 65 mL/min (n.d.); at 12 months, 56 and 54 mL/min (n.d.). Post-transplant PTH levels correlated directly with preoperative levels in both groups and inversely with renal graft function in group 2 recipients.Conclusion. HPT in kidney transplant candidates is a major, graft function-independent predictor of excess PTH secretion in recipients, increasing the risk of persistent HPT 1.9-fold, one year after KT.

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kabwe, Stephen, Gelson Tembo et Thomson Kalinda. « Factors Affecting the Efficiency of Smallholder Cotton Producers in Zambia ». University of Zambia Journal of Agricultural and Biomedical Sciences 1, n^o 1 (31 mars 2012) : 30–36. http://dx.doi.org/10.53974/unza.jabs.1.1.332.

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Agriculture in Sub-Sahara Africa is considered as an engine of economic growth and has the potential to reduce rural poverty of smallholder farmers through increased food security and household income. However, most of Sub-Sahara Africa countries are faced with low agricultural productivity and this has undermined the potential to reduce rural poverty. The study focused on smallholder cotton producers in Zambia. Cotton is grown in Central, Eastern and Southern Provinces of Zambia and is an important cash crop which contributes over $60 million to the economy. It also supports over 150,000 households. However, productivity of smallholder cotton farmers in Zambia is low, around 800 kg per hectare or less. While in West Africa productivityis over 1000 kg perhectare. Agriculturalproductivity is defined as a measure of value of output for a given level of inputs. Efficiency is defined as the actual productivity of a farm relative to a maximal potential productivity.Thisshowsthatefficiencyisrelatedtoproductivity though it is productivity at maximum or minimum values. The study used the 2008 supplemental survey data collected by the Ministry of Agriculture and Cooperatives, Central Statistics and Food Security Research Project. Using Data Envelopment Analysis (DEA) this study determines the technical, allocative and economic efficiency indices of a sample of 812 (population estimates 150,801) cotton producers in Zambia. Using the Ordinary Least Squares (OLS) regression, the study determinesthe factors influencing technical,allocative and economic efficiency variations. Results show that the mean technical, allocative and economic efficiency indices in cotton production are 46%, 37% and 20% respectively. This means that Zambian cotton farmers could reduce input use and production cost without altering the output by improving technical and allocative efficiency by 54% and 63% respectively. Female headed households, number of years spent in school by the household head, leaving crop residues, value of productive assets and off farm income are some of the factors found to positively influence the technical, allocative and economic efficiency. The study found that cotton farmers are relatively inefficient and there is room to improve efficiency among smallholder cotton farmers in Zambia. Some socio-economic and farm specific factors have a positive influence on efficiency. The study recommends that cotton stakeholders should devise strategies of involving more women in cotton production, improve access to productive assets, and encourage adoption of conservation farming crop residue retention as the means to improve cotton production efficiency

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Hu, Xin, Scott D. Grosse, Xuesong Han, Jordan Gilleland Marchak et Xu Ji. « Mental Health Care Utilization Among Parents of Children With Cancer ». JAMA Network Open 7, n^o 4 (2 avril 2024) : e244531. http://dx.doi.org/10.1001/jamanetworkopen.2024.4531.

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ImportanceCaring for children diagnosed with cancer may adversely affect the mental health (MH) of parents.ObjectiveTo characterize utilization of MH services among parents of children with vs without cancer using nationwide commercial claims data.Design, Setting, and ParticipantsFor this cross-sectional study, the Merative MarketScan Commercial Claims Database was used to identify continuously insured families of children treated for cancer (aged ≤21 years at diagnosis) during 2010 to 2018, compared with families who matched eligibility criteria but did not have a child with a cancer history. Parents were assessed from 18 months before to 12 months after their child’s cancer diagnosis. Analyses were conducted from February 2022 to September 2023.ExposuresChildren’s cancer diagnosis.Main Outcomes and MeasuresOutcomes included parents’ MH-related visits during the first year following their child’s cancer diagnosis. Logistic regressions compared outcomes between families of children with vs without cancer, adjusting for sociodemographic and clinical factors.ResultsThis study included 4837 families of children with cancer (4210 mothers and 4016 fathers) and 24 185 families of children without cancer (21 444 mothers and 19 591 fathers) with continuous insurance enrollment. Most household leads were aged 35 to 54 years (3700 [76.5%] in families of children with cancer vs 17 812 [73.6%] in families of children without cancer) and resided in urban areas (4252 [87.9%] vs 21 156 [87.5%]). The probabilities of parents having anxiety-related visits (10.6% vs 7.0%), depression-related visits (8.4% vs 6.1%), and any MH-related visits (18.1% vs 13.3%) were higher in families of children with vs without cancer. Adjusted analyses showed absolute increases of 3.2 percentage points (95% CI, 2.3 to 4.0; 45.7% relative increase), 2.2 percentage points (95% CI, 1.4 to 3.0; 36.1% relative increase), and 4.2 percentage points (95% CI, 3.1 to 5.3; 31.3% relative increase) in the probabilities of 1 or both parents having anxiety-related visits, depression-related visits, and any MH-related visits, respectively, among families of children with vs without cancer. Such differences were greater in magnitude among mothers than fathers.Conclusions and RelevanceIn this cohort study of privately insured parents, those caring for children with cancer had a higher likelihood of utilizing MH care than other parents. These findings underline the importance of interventions toward targeted counseling and support to better meet MH care needs among parents and caregivers of children with cancer.

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D’Heilly, Paige, Amanda Beaudoin, Davis Melin et Stacy Holzbauer. « Characteristics of antibiotic exposures for surgical procedures prior to Clostridioides difficile diagnosis—Minnesota, 2018 ». Antimicrobial Stewardship & ; Healthcare Epidemiology 2, S1 (16 mai 2022) : s27. http://dx.doi.org/10.1017/ash.2022.105.

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Background:Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. Significant risk factors for CDI include antibiotic use and healthcare exposure. Antibiotics are often administered before, during and/or after surgery to prevent postsurgical infection. The contribution of surgery-related antibiotics to the overall CDI burden has not been well described, and assessment of the appropriateness of surgical antibiotic use is complicated by complex clinical guidelines. We have described surgical antibiotic prophylaxis history among adult with CDI in Minnesota in 2018. Method: The Minnesota Department of Health (MDH) performs 5-county active population- and laboratory-based CDI surveillance as a CDC Emerging Infections Program site. Incident CDI was defined as stool positive for C. difficile by toxin or molecular assay from a person aged ≥18 years with no positive test in the preceding 8 weeks. History of CDI was defined as having had a previous CDI episode in the 2009–2018 surveillance data set. Medical records were reviewed for 12 weeks prior to incident CDI test date to identify antibiotic prescriptions. Antibiotics with documented indication for surgical-site infection prevention or surgical prophylaxis were classified as “surgical antibiotic prophylaxis” (SPPX). SPPX type (eg, intraoperative, postoperative), appropriateness of SPPX, and clinical guideline adherence were not assessed. Results: During 2018, 812 incident CDIs were reported to MDH among 736 patients. SPPX preceded 84 (10.3%) cases, non-SPPX antibiotic use preceded 465 cases (57.3%), and 263 cases (32.4%) had no documented prior antibiotic use. The median age of incident CDIs with preceding SPPX was 68 years (IQR, 54–79.5). In 25 incident CDI cases with preceding SPPX (29.8%), there were no other antibiotic exposures. Among incident CDIs with preceding SPPX, 11 (13.1%) had >1 surgery event with SPPX. Prior CDI was identified for 13 (15.7%) with SPPX. Among 99 procedures with preceding SPPX, orthopedic surgeries (n = 27, 27.3%), gastrointestinal surgeries (n = 26, 26.3%), and cardiovascular surgeries (n = 22, 22.2%) were most common. In total 18 SPPX prescriptions (18.2%) originated in outpatient settings. SPPX drugs included cefazolin (n = 67, 67.7%), ceftriaxone (n = 7, 7.1%), ertapenem (n = 6, 6.1%), and clindamycin (n = 6, 6.1%). Median SPPX duration was 1 day (IQR, 1–2), and the median number days between surgery and specimen collection date was 19 (IQR, 7–49). Conclusions: Antibiotic stewardship programs should assess surgical prescribing, including in outpatient centers. Even short antibiotic duration for surgery could put patients at risk for CDI. More data are needed to evaluate the appropriateness of SPPX prescribing and to describe the impact of SPPX on CDI.Funding: NoneDisclosures: None

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Brissot-Davaine, Eolia, Philippe Moreau, Sameh Ayari, Jacques Delaunay, Thierry Guillaume, Jean-Baptiste Pelletier, Jean-Luc Harousseau et Patrice Chevallier. « GVHD Prophylaxis with Cyclosporine + Mycophenolate Mofetil Improves Outcome Compared to Cyclosporine Alone in Patients Receiving Reduced Intensity Conditioning Hematopoietic Stem-Cell Transplantation from Unrelated Donor for Hematological Diseases. » Blood 110, n^o 11 (16 novembre 2007) : 4983. http://dx.doi.org/10.1182/blood.v110.11.4983.4983.

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Abstract Introduction: As observed in myeloablative allograft, incidence of acute and chronic GVHD remains a major problem in patients receiving RIC HSCT in term of TRM and quality of life. So far, the best GVHD prophylaxis has not been yet established in this settings, as it could depend on the type of donor or of the RIC regimen. Thus, GVHD incidence is expected to be higher in patients receiving transplantation from unrelated donor compared to related donor. Here we have compared two GVHD prophylaxis regimen (Cyclosporine (CsA) alone vs CsA + Mycophenolate mofetil (MMF)) in patients receiving RIC allograft from unrelated donor in order to demonstrate the favourable impact of a stronger immmunosupressive treatment in term of overall survival (OS) due to less GVHD incidence. Patients and Methods: We have studied retrospectively 40 successive patients from our institution who received RIC allogeneic HSCT from unrelated donor for haematological malignancies. Two GVHD prophylaxis regimen were administrated: CsA alone in Group 1 (n=19) from 2000 to 2005 and CsA +MMF in Group 2 (n=21) from 2005. Indeed, the observation of high incidence of acute GVHD in the former group conducted us to modify our strategy of GVHD prophylaxis. Almost all patients received a Slavin’s like RIC regimen associating Fludarabine, Busulfan and ATG. The graft consisted of peripheral blood stem cells for all patients except 4 patients in Group 1 who received bone marrow and 3 patients in Group 2 who received unrelated cord blood stem cells. The 2 groups were comparable in term of sex, status at transplant (CR1 vs others) and age at transplant (median age 49 years in Group 1 and 54 years in Group 2, p=0.05). Median follow-up for survival patients were 35 months and 12 months in Group 1 and 2 respectively. All patients have given informed consent. Results: OS was significantly higher in Group 2: median 300 days (range: 36–2620 days) in group 1 versus median not reached (range: 181–812 days) in Group 2. OS was 40% at 1 year in group 1 compared to 92% in Group 2, p=0.0004. This discrepancy was due to the observation of a trend for higher acute GVHD grade III–IV occurrence in group 1 compared to Group 2 (75% vs 41%, p=0.21) and significant more deaths due to acute GVHD in Group 1 compared to Group 2 (4 patients vs 1, p<0.05). No difference was observed in term of relapse when comparing the 2 groups. Conclusion: With restriction due to the short follow-up in Group 2, we demonstrated here the favourable impact of the combination of CsA + MMF as GVHD prophylaxis in patients receiving RIC transplant from unrelated donor as we demonstrate a significant benefit in term of overall survival due to less acute GVHD.

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Jaber Chehayeb, Rachel, Annette Hood, Xiaoliang Wang, Rebecca Miksad, Sarah Schellhorn Mougalian, Maryam B. Lustberg, Shi-Yi Wang, Rachel A. Greenup, Lajos Pusztai et Natalia Kunst. « Treatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021 ». JAMA Network Open 5, n^o 11 (29 novembre 2022) : e2244204. http://dx.doi.org/10.1001/jamanetworkopen.2022.44204.

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ImportanceAdvances in treatment of metastatic breast cancer (MBC) led to changes in clinical practice and treatment costs in the US over the past decade. There is limited information on current MBC treatment sequences and associated costs by MBC subtype in the US.ObjectivesTo identify treatment patterns by MBC subtype and associated anticancer and supportive drug costs from health care sector and Medicare perspectives.Design, Setting, and ParticipantsThis economic evaluation analyzed data of patients with MBC obtained from the nationwide Flatiron Health database, an electronic health record–derived, deidentified database with data from community and academic practices across the US from 2011 to 2021. Participants included women aged at least 18 years diagnosed with MBC, who had at least 6 months of follow-up data, known hormone receptor (HR) and human epidermal growth factor receptor 2 (ERBB2) receptor status, and at least 1 documented line of therapy. Patients with documented receipt of clinical study drugs were excluded. Data were analyzed from June 2021 to May 2022.Main Outcomes and MeasuresOutcomes of interest were frequency of different drug regimens received as a line of therapy by subtype for the first 5 lines and mean medical costs of documented anticancer treatment and supportive care drugs per patient by MBC subtype and years since metastatic diagnosis, indexed to 2021 US dollars.ResultsAmong 15 215 patients (10 171 patients [66.85%] with HR-positive and ERBB2-negative MBC; 2785 patients [18.30%] with HR-positive and ERBB2-positive MBC; 802 patients [5.27%] with HR-negative and ERBB2-positive MBC; 1457 patients [9.58%] with triple-negative breast cancer [TNBC]) who met eligibility criteria, 1777 (11.68%) were African American, 363 (2.39%) were Asian, and 9800 (64.41%) were White; the median (range) age was 64 (21-84) years. The mean total per-patient treatment and supportive care drug cost using publicly available Medicare prices was $334 812 for patients with HR-positive and ERBB2-positive MBC, $284 609 for patients with HR-negative and ERBB2-positive MBC, $104 774 for patients with HR-positive and ERBB2-negative MBC, and $54 355 for patients with TNBC. From 2011 to 2019 (most recent complete year 1 data are for patients diagnosed in 2019), annual costs in year 1 increased from $12 986 to $80 563 for ERBB2-negative and HR-positive MBC, $99 997 to $156 712 for ERBB2-positive and HR-positive MBC, and $31 397 to $53 775 for TNBC.Conclusions and RelevanceThis economic evaluation found that drug costs related to MBC treatment increased between 2011 and 2021 and differed by tumor subtype. These findings suggest the growing financial burden of MBC treatment in the US and highlights the importance of performing more accurate cost-effectiveness analysis of novel adjuvant therapies that aim to reduce metastatic recurrence rates for early-stage breast cancer.

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Wake, Atsushi, Shunro Kai, Masaya Okada, Koji Kato, Naoyuki Uchida, Naoki Kobayashi, Nobuyuki Aotsuka et al. « Comparison of Outcomes after Double or Single-Unit Cord Blood Transplantation in Patients with Hematological Malignancies Using TBI-Containing Myeloablative Conditioning Regimen, a Retrospective Matched Control Study on Behalf of C-SHOT0507 and JSHCT Registry Data in Japan ». Blood 124, n^o 21 (6 décembre 2014) : 2548. http://dx.doi.org/10.1182/blood.v124.21.2548.2548.

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Abstract INTRODUCITON: We reported the outcomes of double-unit cord blood transplantation (dCBT) after myeloablative conditioning performed in a prospective multicenter phase II study (C-SHOT0507) (Biol Blood Marrow Transplant 19, 2013: 812-819). However, the benefit of using double unit compared to single unit was not clearly shown. We performed matched control analysis to compare dCBT and single-unit CBT (sCBT), using C-SHOT0507 data of dCBT and registry data of sCBT. METHODS: Between Apr.2006 and Jan.2010, 61 cases of dCBT in C-SHOT0507 phase II clinical study and 932 cases of sCBT were performed in Japan. Because all cases of dCBT perfomed by TBI12Gy containing myeloablative conditioning (CA/Cy/TBI +/- G-CSF for myeloid and Cy/TBI for lymphoid) and uniform GVHD prophylaxis (CSA/MTX), we excluded reduced intensity conditioning and myeloablative conditioning without TBI 12 Gy from the cases of sCBT. Finally 307 sCBT patients who had hematological malignancies (AML170, ALL80, MDS24, CML14 and ML20) were extracted. All the sCBT recipients received uniform preconditioning described above and same GVHD prophylaxis (CSA/MTX), selected as a matched control cohort of dCBT C-SHOT0507 study. All statistical analyses were performed using EZR (Kanda Y, Saitama Medical Center, Jichi Medical University), a graphical user interface for R (The R Foundation for Statistical Computing, version 2.13.0). RESULTS: Median observation period of survivors was 1431 (106-2315) days post-transplant. Backgrounds of dCBT group and matched-control sCBT group were comparable except gender: (dCBT:M/F = 53 /8 versus sCBT:M/F = 154/153). Median age were 37 (10-54) in dCBT and 40 (14-54) in sCBT. Disease risk included standard 27, advanced 34 cases in dCBT, and standard 142, advanced 165 cases in sCBT. sCBT were grouped according to infused TNC number; 148 cases of low TNC (<2.5x107/kg) group (lowTNC) including 35 cases of <2.0x107/kg, and 159 cases of high TNC (>=2.5x107/kg) group (highTNC). Cumulative incidence (C.I.) of neutrophil engraftment were 87.2% (69.5-95.0) in dCBT, 84.7% (76.2-90.3) in sCBT of low TNC and 86.8% (79.3-91.7) in those of high TNC (n.s.) [Figure] and median days of engraftment were 25, 23, 22 days, respectively. 3yEFS were 44.3% (31.8-56.7), 41.6% (33.5-49.7), 44.0% (36.1-51.9) [Figure], and 3yOS were 52.3% (39.7-64.8), 48.7% (40.5-56.9), 51.0%(43.1-59.0), respectively. There were no statistically significant differences in both of them. C.I. of NRM were 24.1% (13.9-35.7), 31.0% (22.0-40.3), 40.0% (18.0-61.3), acute GVHDII-IV were 30.8% (18.2-44.4), 41.9% (33.1-50.4), 54.8% (45.5-63.1), acute GVHDIII-IV were 10.8% (3.2-23.6), 12.7% (6.8-20.6), 19.0% (11.4-28.1), chronic GVHD were 31.6% (19.8-44.1), 41.4% (32.6-50.0), 33.8% (26.2-41.6), and relapse incidences were 24.6% (14.6-36.1), 24.5% (17.7-31.8), 26.3% (19.6-33.5), respectively. All parameters assessed showed no significant differences between dCBT, sCBT, sCBT of low TNC and high TNC, except C.I of acute GVHDII-IV and NRM. In multivariate analysis, disease risk was an only significant factor affected on EFS (HR0.58; 95%CI: 0.400-0.833, P=0.003). DISCUSSION: Although this is a retrospective analysis, double-unit use for CBT showed no statistically significant impact on engraftment rate and transplant outcomes compared to single-unit use of CBT even in patients of TNC number lower than 2.5x107/kg after myeloablative conditioning in Japan. Since more than 90% of the transplant candidates can find single CB unit >2x107/kg TNC, advantage of adding another CB unit may be quite limited in Japan both scientifically and financially, until meaningful benefit is demonstrated by randomized phase III study such as BMT-CTN 0501. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.

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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos et R. Chebel. « 11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018 ». Reproduction, Fertility and Development 32, n^o 2 (2020) : 130. http://dx.doi.org/10.1071/rdv32n2ab11.

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Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis was done by transrectal ultrasonography at 32-46 days in VH and by the IDEXX PAG test at 30 days in LC. June, July, August, September, and October were called critical months (first service AI conception rate drops below 44%) and compared with the other months. The data from 32 503 ETs between January 2008 and December 2018 are summarised on Table 1. Pregnancy rates (PR) are lower for LC recipients than for VH. Embryo transfers performed 7 or 8 days after oestrus had higher PR in both types of recipients and embryos, but Day 6 and 9 oestrus are also used with fair results. The season does not seem to affect PR. There is not enough difference in the combination of stage and days from oestrus for invivo-derived embryos. These numbers do not belong to a planned experiment. Several management changes during the years were made, which make it very difficult to apply statistical methods to analyse the data correctly. They are used as a tool to make decisions in an attempt to improve future results. Table 1.Pregnancy rate (PR) of virgin heifers (top) and lactating cows (bottom)-fresh (SH) and frozen (OZ) invivo-derived embryo transfer1 Heat-months SH-ST4 SH-ST5 SH-ST6 SH-All OZ-ST4 OZ-ST5 OZ-ST6 OZ-All PR% n PR% n PR% n PR% n PR% n PR% n PR% n PR% n Heifers 6 d-CM 62 934 66 243 68 69 63 1246 56 473 58 219 62 42 57 734 6 d-OM 62 1623 67 489 69 211 64 2323 56 600 55 296 48 137 55 1033 6 d-T 62 2557 67 732 69 280 63 3569 56 1073 57 515 51 179 56 1767 7 d-CM 64 1506 68 495 67 221 65 2222 60 822 62 340 63 156 61 1318 7 d-OM 66 2723 68 1021 69 510 67 4254 57 1120 59 581 57 231 58 1932 7 d-T 66 4229 68 1516 69 731 67 6476 58 1942 60 921 60 387 59 3250 8 d-CM 65 1348 64 518 67 322 65 2188 59 595 64 258 63 108 61 961 8 d-OM 66 2166 68 886 70 510 67 3562 61 770 60 364 51 130 60 1264 8 d-T 66 3514 67 1404 69 832 66 5750 60 1365 62 622 56 238 60 2225 9 d-CM 60 109 56 43 70 20 60 172 60 5 33 6 50 4 47 15 9 d-OM 58 129 63 57 60 40 60 226 63 16 50 18 75 4 58 38 9 d-T 59 238 60 100 63 60 60 398 62 21 46 24 63 8 55 53 All-CM 64 3897 66 1299 67 632 65 5828 58 1895 61 823 63 310 60 3028 All-OM 65 6641 67 2453 69 1271 66 10 365 58 2506 58 1259 53 502 58 4267 All-T 65 10 538 67 3752 69 1903 66 16 193 58 4401 60 2082 57 812 59 7295 Lactating cows 6 d-CM 54 265 48 86 50 12 53 363 38 141 31 77 50 10 36 228 6 d-OM 49 463 52 203 45 56 50 723 46 101 48 54 59 27 48 182 6 d-T 51 728 51 289 46 68 51 1086 41 242 38 131 57 37 42 410 7 d-CM 54 755 59 274 56 103 55 1137 43 928 48 450 43 192 45 1570 7 d-OM 55 914 66 367 54 109 58 1393 46 1052 45 564 47 353 46 1969 7 d-T 55 1669 63 641 55 212 57 2530 45 1980 46 1014 46 545 45 3539 8 d-CM 63 252 68 82 76 33 65 368 48 219 56 80 42 33 50 332 8 d-OM 61 257 64 161 53 47 61 466 50 191 53 77 56 16 51 284 8 d-T 62 509 65 243 63 80 63 834 49 410 55 157 47 49 50 616 All-CM 56 1272 58 442 60 148 57 1868 44 1288 47 607 43 235 45 2130 All-OM 55 1634 62 731 51 212 56 2582 47 1344 46 695 48 396 47 2435 All-T 55 2906 60 1173 55 360 57 4450 45 2632 47 1302 46 631 46 4565 1ST=stage; CM=critical months (June, July, August, September, and October); OM=other months.

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Knop, Stefan, Katja Bauer, Holger Hebart, Hannes Wandt, Lorenz Trumper, Peter Liebisch, Georg Maschmeyer et al. « A Randomized Comparison of Total-Marrow Irradiation, Busulfan and Cyclophosphamide with Tandem High-Dose Melphalan in Patients with Multiple Myeloma. » Blood 110, n^o 11 (16 novembre 2007) : 728. http://dx.doi.org/10.1182/blood.v110.11.728.728.

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Abstract Background Myeloablative chemotherapy with support of autologous peripheral blood stem cells (APBSC) has widely been accepted as a standard of care in patients (pts) with newly diagnosed multiple myeloma (MM). High-dose (HD) melphalan (Mel) 200 mg/m2 was considered superior to total-body irradiaton (TBI) plus Mel 140 mg/m2 for toxicity reasons. Since MM plasma cells are inherently responsive to irradiation, our group evaluated TBI aimed at reduced organ toxicity by shielding lungs and liver (total-marrow irradiation [TMI], 9 Gy) combined with busulfan (Bu, 12 mg/kg) and cyclophosphamide (Cy, 120 mg/kg) in a previous phase I/II trial (Einsele et al, Bone Marrow Transplant, 2003). Patients and methods In the current study (DSMM I), subjects with previously untreated MM in Durie-Salmon stages II/III were randomly assigned to either receive one course of TMI/Bu/Cy versus two cycles of HD Mel 200 mg/m2 each with APBSC transplantation if having had an adequate number of stem cells collected and at least stable disease. Primary end point was event-free survival (EFS), secondary end points overall (OS) and disease-free survival (DFS). Results A total of 294 pts (median age, 54 years), 246 of whom completed stem cell harvest were enrolled between 8/1998 and 1/2002 by 46 centres. Eventually, 198 (n=100 TMI/Bu/Cy and n=98 HD Mel) pts were randomized and included into the ITT population. The safety population (n=80 TMI and n=118 HD Mel, due to 18 pts switching to Mel) was analyzed for toxicity and response. CR rate before HD therapy was 7.0% (7/100) in the TMI and 6.1% (6/98) in the Mel arm respectively. Significantly more pts receiving TMI/Bu/Cy experienced WHO grades 3 and 4 pulmonary and gastrointestinal toxicity and pain. Following HDT, CR rate increased to 17.5% (14/80, TMI) and 32.2% (38/118, HD Mel; p=.022) respectively. After a median follow-up of 1447 days, median EFS in the TMI group was 1161 days versus 1090 days for HD Mel (p=.812). Probability of 4-year OS was 72.7% (95%-CI: 62.1–80.7) with TMI and also 72.7% (95%-CI: 61.7–81.1) after HD Mel (p=.754). For pts in CR following HD therapy, probability of 4 year DFS was 62.4% (95%-CI: 33.6–81.6) for TMI vs. 50.4% (95%-CI: 30.6–67.3) for HD-Mel (p=.138). Conclusion In this randomized trial on pts with newly diagnosed MM, the irradiation-based regimen was associated with more pulmonary and GI toxicity when compared to HD Mel. Incidences of other toxicities including hepatotoxicity, however, were not different between the two treatment arms. CR rate was superior for HD-Mel, while there was no difference in OS and EFS between the two treatment arms. Subjects achieving CR may be more likely to enjoy prolonged DFS after TMI/Bu/Cy.

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Jamal, Ahmedin, Robert Winn, William Cance, Tim Johnson et Wayne Lilyestrom. « Abstract C108 : Employer-based implementation of Galleri multi-cancer early detection testing to address socioeconomic disparities in receipt of screening ». Cancer Epidemiology, Biomarkers & ; Prevention 32, n^o 12_Supplement (1 décembre 2023) : C108. http://dx.doi.org/10.1158/1538-7755.disp23-c108.

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Abstract Background: Multi-cancer early detection (MCED) tests are designed to complement USPSTF-recommended screening to detect many cancers for which no established screening methods exist. Implementing an MCED test as an employee benefit offers an approach to detect cancers for which there is no screening method and to address socioeconomic disparities in receipt of screening. Methods: Galleri, a blood-based MCED test, was implemented in companies with employees in industrial/manufacturing spaces. We approximated educational attainment (≤12 years vs >12 years) as a dichotomous measurement of socioeconomic status (SES). The industrial locations with employees of lower SES were selected based on data from individual companies and focused on diverse employees, low rates of preventive screenings, high healthcare costs, and low health literacy. Enrollment was accomplished through on-site events where consent and blood draws were available, as well as telehealth visits with subsequent blood draws. Results: From October 2021 to May 2023, 812 Galleri MCED tests were administered in a population of industrial employees. Of the participants, 317 (39%) were female and 495 (61%) were male, and the median age was 54 years. A total of 217 (27%) participants were aged 35-49, 531 (65%) were aged 50-64, and 62 (8%) were aged 65-79. Four tests returned a cancer signal detected result with a predicted cancer signal origin of colorectal (n=2), anus (n=1), and breast (n=1). Of the four participants with a cancer signal detected result, three were in the 50-64 age group and one was in the 65-79 age group. The breast cancer diagnosis was confirmed, and follow-up is ongoing in the participants with a cancer sign origin of colorectal and anus. A total of 676 (83%) tests were administered during 9 on-site events and 136 (17%) were obtained by telehealth visits. Factors that were important for taking the Galleri test were onsite events, trusted long-time employees onsite that spoke their language and helped translate the request form, explanation of the test in their native language, and the ability to administer the test without a computer or other digital requirements. Conclusion: MCED testing may be implemented more widely among individuals of lower SES when it is included as an employee benefit with in-person communication by trusted employee messengers and by limiting digital requirements. Supporting the unique needs of individuals before administering an MCED test and those with a cancer signal detected result are important steps for improving access and achieving diagnostic resolution. Citation Format: Ahmedin Jamal, Robert Winn, William Cance, Tim Johnson, Wayne Lilyestrom. Employer-based implementation of Galleri multi-cancer early detection testing to address socioeconomic disparities in receipt of screening [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C108.

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Hanna, Glenn J., Scott Roof, James Jabalee, Eleni M. Rettig, Rocco M. Ferrandino, Sida Chen, Marshall Posner et al. « Abstract 3360 : Negative predictive value of circulating tumor tissue modified viral HPV DNA for identifying recurrence among patients treated for HPV-driven oropharyngeal cancer ». Cancer Research 83, n^o 7_Supplement (4 avril 2023) : 3360. http://dx.doi.org/10.1158/1538-7445.am2023-3360.

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Abstract Purpose: Despite favorable outcomes, up to 20% of patients with human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) will experience recurrence. Monitoring circulating tumor tissue modified viral (TTMV)-HPV DNA during post-treatment surveillance has emerged as a tool that has demonstrated >95% positive predictive value (PPV) for detecting recurrence. Here we describe a large real-world population with detailed clinical follow-up, permitting determination of the longitudinal negative predictive value (NPV) of the assay. Patients and methods: This IRB-approved, retrospective observational cohort study included 312 patients across five U.S. centers who were ≥3 months post-treatment for HPV-driven OPSCC. Patients had one or more TTMV-HPV DNA results (NavDx®, Naveris Laboratories) obtained during surveillance between February 2020 and January 2021. A baseline TTMV-HPV DNA test was not required. HPV status was assessed by p16 immunohistochemistry or HPV PCR/ISH. Test results were correlated with physician-reported exam and imaging findings to assess disease status in follow-up. Results: The cohort was mostly male (85%), had a median age of 61 (range: 27-81), included smokers (50%), and 282 (90%) had involved nodes (N1: 204, N2: 70, N3: 8) at initial staging. Curative-intent treatment involved surgery with or without another modality in 54% of cases (169/312). Median follow-up time was 23.5 months, and 39 patients (12.5%) had documented recurrence. Most patients had >1 TTMV-HPV DNA test result ≥3 months post-treatment (231, 74%), with 48 (15%) having 5 or more tests. Among patients with multiple negative surveillance tests, the median time between tests was 126 days (4.2 months, range: 0.37-24.2). The first TTMV-HPV DNA surveillance test was most often performed within the first year post-treatment (195, 63%). Across 812 test results, the NPV was 99.5%. There were 4 false negative tests among patients with confirmed p16-positive (3/4) or HPV PCR-positive (1/4) biopsy-proven recurrence. One of these patients had a subsequent positive TTMV-HPV DNA test during salvage immunotherapy. Only one of these patients had baseline TTMV-HPV DNA testing available, which showed a low positive <50 TTMV-HPV16 DNA Score, whereas the other three patients did not have a baseline result available. Conclusion: Our findings further support the clinical potential of monitoring circulating TTMV-HPV DNA during post-treatment surveillance. We demonstrate a very high assay NPV correlated with physician-reported outcomes. TTMV-HPV DNA can be used to assist in surveillance and could inform imaging needs and future practice guidelines for HPV-driven head and neck cancer survivors. Citation Format: Glenn J. Hanna, Scott Roof, James Jabalee, Eleni M. Rettig, Rocco M. Ferrandino, Sida Chen, Marshall Posner, Krzysztof J. Misiukiewicz, Eric M. Genden, Raymond L. Chai, John Sims, Elaine Thrash, Scott J. Stern, Adam Raben, Lydia I. Clements, Abie H. Mendelsohn, Charlotte Kuperwasser, Catherine Del Vecchio Fitz, Barry M. Berger. Negative predictive value of circulating tumor tissue modified viral HPV DNA for identifying recurrence among patients treated for HPV-driven oropharyngeal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3360.

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Nabi, H., R. Ibsen, M. Ibsen, J. Kjellberg, M. L. Hetland et B. Glintborg. « POS0376 DOES A MANDATORY SWITCH FROM ORIGINATOR ADALIMUMAB TO BIOSIMILAR GP2017 OR SB5 LEAD TO INCREASED HOSPITAL COSTS ? A DANBIO STUDY OF >1,300 PATIENTS WITH INFLAMMATORY ARTHRITIS ». Annals of the Rheumatic Diseases 82, Suppl 1 (30 mai 2023) : 441–42. http://dx.doi.org/10.1136/annrheumdis-2023-eular.812.

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BackgroundIn 2018, Danish national guidelines dictated a mandatory switch from originator to biosimilar adalimumab based on geographical residence, i.e., GP2017 in Eastern regions and SB5 in Western regions of Denmark[1]. The switch was motivated by cost savings (approx. 34-49%). Concerns were raised if hospitals would encounter additional costs as a result of increased numbers of outpatient visits/contacts (due to patient concerns, education, treatment monitoring).ObjectivesTo investigate if the switch from originator to either of the adalimumab biosimilars led to increased hospital costs, defined as all in- and outpatient contacts.MethodsObservational cohort study with surrogate cluster (i.e. geographical) pseudo-randomization. Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or axial spondyloartritis (AxSpA), who performed an adalimumab biosimilar switch were identified in the rheumatology registry, DANBIO. Hospital contacts were identified through linkage to the National Patient Registry. Hospital costs (based on DRG tariffs) were reported 9 months pre- and post-switch. In addition, the difference between pre- and postswitch costs was estimated by a generalized estimation equations (GEE) model. Medication costs of adalimumab originator and biosimilars were not available, and thus not included in the model.Results1,318 patients were included (51% male, mean disease duration 16 years) and switched to either GP2017 (n=621) or SB5 (n=695). Baseline characteristics for both treatment groups stratified by diagnosis are given inTable 1.Monthly hospital costs 9 months pre- and post-switch were largely similar or decreased post-switch (Figure 1). No increase was found in the adjusted analyses (GEE); hospital costs decreased post-switch (by approximately 15%) for GP2017 switchers, especially PsA (estimate 0.83; 95% CI 0.75-0.92) and AxSpA patients (estimate 0.85;0.77-0.93), whereas no significant changes were found for SB5 switchers (Table 1).ConclusionIn this study of >1,300 patient with inflammatory arthritis, we found no sign of increased healthcare hospital costs 9 months following a nationwide mandatory adalimumab originator to biosimilar switch. Our findings were strengthened by similar results regardless of whether patients switched to GP2017 or SB5.Reference[1]Nabi H, Georgiadis S, Loft AG, et al. Ann Rheum Dis, doi:10.1136/annrheumdis-2021-219951Figure 1.Hospital costs stratified by biosimilar drug. Black dotted line indicates time of switch. y-axis: Mean cost per patient per monthTable 1.Baseline characteristics of patients who switched from originator adalimumab to biosimilar GP2017 or SB5, stratified by diagnosisGP2017 (n=621)SB5 (n=695)PSARAAxSpAPsARAAxSpANumber of patients (N)146213262173253269Age, years (mean, SD)54 (11)62 (11)48 (12)55 (11)63 (10)49 (11)Female, n (%)80 (55)158 (74)82 (31)58 (34)181 (72)89 (3)Disease duration, years (mean, SD)14 (7)18 (9)14 (10)15 (8)19 (10)14 (8)Duration of originator adalimumab treatment before switch (n,%) <6 years43 (29)59 (28)72 (27)36 (21)34 (13)68 (25) ≥6 years103 (71)154 (72)190 (73)137 (79)219 (87)201 (75)Stopped biosimilar treatment within 180 days (n, %)10 (7)8 (4)15 (6)6 (4)18 (7)16 (6)GLM regression estimates for costs after versus before switching, stratified by drug and diagnosis*GP2017SB5PsARAAxSpAPsARAAxSpATotal hospital costs0.83 (0.75-0.92)§0.99 (0.86-1.14)0.85 (0.77-0.93)§1.03 (0.95-1.13)1.00 (0.93-1.08)1.01 (0.91-1.12)*Adjusted for gender, age, duration of treatment with originator drug (6+ years=1), stopped the medication within 6 months (yes-no) and comorbidity (number of WHO 21 chapters excluding WHO 13 ICD-10 M). After=1 included as a dummy variable, and the estimates for this shows whether there were changes over time.§p-values <0.05.AcknowledgementsWe thank all the Danish departments of rheumatology, which report to the DANBIO registry. Also the work of IT consultant Niels Steen Krogh, Zitelab Aps, who extracted data from DANBIO is acknowledged.Disclosure of InterestsHafsah Nabi Grant/research support from: Research grant from AbbVie, who had no influence on the data collection, statistical analyses or decision to submit.Other research grants: Sandoz, Rikke Ibsen: None declared, Michael Ibsen: None declared, Jakob Kjellberg: None declared, Merete L. Hetland Speakers bureau: Biogen, Celtrion, Janssen Biologics B.V, MSD, Pfizer, Samsung Bioepis, Consultant of: Biogen, Celtrion, Janssen Biologics B.V, MSD, Pfizer, Samsung Bioepis, Grant/research support from: AbbVie, Biogen, BMS, Eli Lilly Denmark A/S, Lundbeck Fonden, Novartis, Pfizer, Roche, Sandoz., Bente Glintborg Grant/research support from: BMS, Pfizer, Sandoz.

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Sibagariang, Pradita Permatasari, et Weny Savitry S. Pandia. « Teaching Approach and Teacher Self-Efficacy during Early Childhood Distance Learning ». JPUD - Jurnal Pendidikan Usia Dini 15, n^o 1 (30 avril 2021) : 41–59. http://dx.doi.org/10.21009/jpud.151.03.

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Child Distance Learning (CDL) during the pandemic has led to an optimal development of children and effective teaching and learning processes in kindergartens. To overcome this, teachers need to apply a teaching approach in accordance with the principles of kindergarten education. In addition, teachers' self-efficacy of their ability to teach is also important for developing children's skills. This study aims to describe the teaching approach and the efficacy of kindergarten teachers during the CDL process and to identify the relationship between the two. The research method used is quantitative through document analysis as a source of data findings. A total of 116 Public Kindergarten (PK) teachers in DKI Jakarta participated in filling out the Classroom Management Scale and Teachers' Sense of Efficacy Scale online. All data were processed using descriptive statistics and correlation. Furthermore, there is a document analysis carried out on the Daily / Weekly Learning Program Design in PK Jakarta. The findings identified that the teaching approach of kindergarten teachers during CDL included only two principles of kindergarten education, namely thematic teaching and developing life skills. Furthermore, PK teachers in the Jakarta area showed low self-efficacy during CDL. The teaching approach and self-efficacy were caused by teachers' unpreparedness in facing challenges during CDL. In addition, other findings indicate that there is a relationship between teaching approaches and teacher self-efficacy. Another CDL model Interventions to increase teacher self-efficacy and the extent to which the relationship between the two variables can be studied further in future studies. Keywords: Early Childhood, Distance Learning, Teaching Approach, Teacher Self-Efficacy References: Agustin, M., & Wahyudin, U. (2011). Penilaian perkembangan anak usia dini. Refika Aditama. Agustin, M., Puspita, R. D., Nurinten, D., & Nafiqoh, H. (2020). Tipikal Kendala Guru PAUD dalam Mengajar pada Masa Pandemi Covid 19 dan Implikasinya. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 5(1), 334. https://doi.org/10.31004/obsesi.v5i1.598 Ayu, N. (2015). Pengelolaan Kurikulum 2013 Di Tk Negeri Pembina Semarang. Program Sarjana Universitas Negeri Semarang. Bullock, A., Coplan, R. J., & Bosacki, S. (2015). Exploring links between early childhood educators’ psychological characteristics and classroom management self-efficacy beliefs. Canadian Journal of Behavioural Science, 47(2), 175–183. https://doi.org/10.1037/a0038547 Cheung, S. K., Fong, R. W. tsz, Leung, S. K. Y., & Ling, E. K. wei. (2019). The Roles of Hong Kong Preservice Early Childhood Teachers’ Creativity and Zest in Their Self-efficacy in Creating Child-centered Learning Environments. Early Education and Development, 30(6), 788–799. https://doi.org/10.1080/10409289.2019.1586224 Choi, J., Lee, J., & Kim, B. (2019). How does learner-centered education affect teacher self-efficacy? The case of project-based learning in Korea. Teaching and Teacher Education, 85, 45–57. Dimyati, J. (2016). Pembelajaran terpadu untuk taman kanak-kanak/ raudhatul athfal dan sekolah dasar. Prenamedia Group. Dinçer, Ç., & Akgün, E. (2015). Developing a classroom management skills inventory for preschool teachers and the correlation of preschool teachers’ classroom management skills with different variables. Egitim Ve Bilim, 40(117). Duffin, L., Patrick, H., & French, B. (2012). The teachers’ sense of efficacy scale: Confirming the factor structure with beginning pre-service teachers. Teaching and Teacher Education: An International Journal of Research and Studies, 28(6), 827–834. Essa, E. (2011). Introduction to early childhood education. Wadsworth. Harwati, D., & Mariyanti, S. (2014). Hubungan antara self-efficacy dengan burnout pada pengajar taman kanak-kanak sekolah “X” di Jakarta. Jurnal Psikologi, 12(2), 54–60. Ismawati, D., & Prasetyo, I. (2020). Efektivitas pembelajaran menggunakan video zoom cloud meeting pada anak usia dini era pandemi covid-19. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 5(1), 665-675. DOI: 10.31004/obsesi. v5i1.671 Jackman, H. (2011). Early education curriculum: A child’s connection to the world. Delmar Thomson Learning. Jalal, M. (2020). Kesiapan guru menghadapi pembelajaran jarak jauh di masa covid-19. Smart Kids: Jurnal Pendidikan Islam Anak Usa Dini, 2(1), 35–40. Johar, R., & Hanum, L. (2016). Strategi belajar mengajar. Penerbit Deepublish. Klassen, R. M., & Chiu, M. M. (2010). Effects on teachers’ self-efficacy and job satisfaction: Teacher gender, years of experience, and job stress. Journal of Educational Psychology, 102(3), 741–756. https://doi.org/10.1037/a0019237 Lee, C., & Davis, H. (2014). Teacher self-efficacy. In W. Scarlett (Ed.), The sage encyclopedia of classroom management (Vol. 2, pp. 811-812). SAGE Publications Inc., https://www.doi.org/10.4135/9781483346243.n341. Masdudi, M. (2016). Karakteristik perkembangan pendidikan anak usia dini. Jurnal Pendidikan Anak, 1(2), 1-26. Moran, M., & Hoy, A. (2001). Teacher efficacy: capturing an elusive construct. Teaching and Teacher Education, 17, 783-805. Mulyani, S., Nasution, E., & Pratiwi, I. (2020). Hubungan efikasi diri dan keterikatan kerja guru taman kanak-kanak. JP3SDM, 9(1), 74-89. Ndari., & Chandrawaty. (2018). Telaah kurikulum pendidikan anak usia dini. Edu Publisher. Nindiati, D. (2020). Pengelolaan pembelajaran jarak jauh yang memandirikan siswa dan implikasinya pada pelayanan pendidikan. Journal of Education and Instruction, 3(1), 14-20. Restyningtyas, D. (2013). Penerapan Child Centered pada Anak Usia Dini di Taman Anak (TA) Sanggar Anak Alam (SALAM). Fakultkas Ilmu Pendidikan Universitas Negeri Yogyakarta. Saifulloh, A. M., & Darwis, M. (2020). Manajemen pembelajaran dalam meningkatkan efektifikas proses belajar mengajar di masa pandemic covid-19. Jurnal Pendidikan Guru Madrasah Ibtidaiyah. 3(2). Saptaningrum, ernawati & wiwik, & refiane, fine. (2012). Model pembelajaran aktif kreatif efektif menyenangkan melalui pendekatan tematik untuk pembelajaran sains. Jurnal penelitian pembelajaran fisika. 2. 10.26877/jp2f.v2i1/april.125. Scarlett, W. (Ed.) (2014). The sage encyclopedia of classroom management. (Vols. 1-2). SAGE Publications Inc., https://www.doi.org/10.4135/9781483346243 Schweinhart, L. (2016). Child-initiated learning. In D. Couchenour, & J. Chrisman (Eds.), The sage encyclopedia of contemporary early childhood education (pp. 231-233). SAGE Publications, Inc, https://www.doi.org/10.4135/9781483340333.n61 Shaukat, S., & Iqbal, H. (2012). Teacher self-efficacy as a function of student engagement, instructional strategies, and classroom management. Pakistan Journal of Social and Clinical Psychology, 9(3), 82-85. Soedjono, 2008. Pembelajaran Sains Moderen. http://www.guru-scn/pakem.html. Syarah, E. S., Mayuni, I., & Dhieni, N. (2020). Understanding Teacher's Perspectives in Media Literacy Education as an Empowerment Instrument of Blended Learning in Early Childhood Classroom. Jurnal Pendidikan Usia Dini, 14(2), 201-214. Tiara, D. R., & Pratiwi, E. (2020). Mengukur Kesiapan Guru Sebagai Dasar Pembelajaran Daring Di Lembaga PAUD. Jurnal Golden Age, 4(02), 362-368. Utami, dkk. (2014). Modul PLPG pendidikan anak usia dini, Buku I. Konsorsium Sertifikasi Guru. Yusnita, N., & Muqowim. (2020). Pendekatan student centered learning dalam menanamkan karakter disiplin dan mandiri anak di TK Annur II. Jurnal Ilmiah Potentia, 5(2), 116–126.

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Editor, E. « Retraction notice ». Genetika 55, n^o 2 (2023) : 791. http://dx.doi.org/10.2298/gensr2302791e.

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The article listed below, published in journal Genetika has been retracted due to evidence indicating that the peer review of this paper was compromised, using of frauted data, high number of unfitting citation, overoll general misconduct related to professional codes of ethics. All papers which belong to this group have passed a regular review process. As part of the reviewing process, according to Journal policy, it is expected from reviewers to check all relevant data including citations probity. All papers were published after two positive reviewers? opinions. The journal Genetika condemns such an unethical behavior and will take all necessary measures to ensure that such incidents do not happen again in the future. Authors of those papers as well reviewers are barred from publishing in the journal Genetika in the future and will be blacklisted by the journal. The list of retracted articles is: 1. Bouzarisaravani Z., F. Sharifnia, F. Salimpour, S. Arbabian, A. Geran (2021). Molecular systematic studies in the genus Glaucium (Papaveraceae). - Genetika, Vol 53, No.3, 1179-1192 https://doi.org/10.2298/GENSR2103179B 2. Hang L., L. Pan, T. Yong, L. Jianguo, X. Xingmin, Faisal (2021). Population genetic structure and gene flow in Alcea aucheri (boiss.) Alef.: a potential medicinal plant- Genetika, Vol 53, No.2, 867-882. https://doi.org/10.2298/GENSR2102867H 3. Jiao L., H. Xiao, X. Zhao, F. M. Abarghuei (2021). RAPD profiling in detecting genetic variation in Glaucium (Papaveraceae) species: Edible and Medicinal plant. - Genetika, Vol 53, No.3,1081 - 1092. https://doi.org/10.2298/GENSR2103081J 4. Li H., H. Yu, X. Zeng, S. Hussein Hamarashid (2021). Study on genetic diversity between Malva L. (Malvaceae): a high value medicinal plant using SCoT molecular markers.- Genetika, Vol 53, No.2, 895-910 https://doi.org/10.2298/GENSR2102895L 5. Li H., Y. Wang, R, Iqbal (2021). SCoT molecular markers and population differentiation in Hedera helix L.. - Genetika, Vol 53, No.2, 739-756. https://doi.org/10.2298/GENSR2102739L 6. Li J., X. Yang, S.Mehri (2021). Genetic diversity in Stellaria L. (Caryophyllaceae) using sequence related amplified polymorphism. - Genetika, Vol 53, No.3, 1369 - 1377. https://doi.org/10.2298/GENSR2103369L 7. Lin L., L. Lin, A.Waheed (2021). Assessment of genetic structure and diversity of Erodium (Geranaiceae) species. - Genetika, Vol 53, No.2, 507-520. https://doi.org/10.2298/GENSR2102507L 8. Li S. X. Jiang, S. Mehri (2021). Genetic diversity and gene-pool of Aegilops tauschii coss. (Poaceae) based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1331- 1340. https://doi.org/10.2298/GENSR2103331L 9. Ma X., H. Tian, H. Xia, Zeenat (2021). Genetic diversity of Lonicera L. (caprifoliaceae) estimated by molecular markers and morphological characters. - Genetika, Vol 53, No.2, 651-662. https://doi.org/10.2298/GENSR2102651M 10. Mahdavi M., F. Sharifnia, F.Salimpour, A. Esmaeili, M. Larypoor (2021). Genetic diversity and population structure of Iranian pistachio (Pistacia vera L.) cultivars.- Genetika, Vol 53, No.2, 671-686 https://doi.org/10.2298/GENSR2102671M 11. Meng K., J. Yao, C.Y. He and H. Morabbi Heravi (2021). Gene flow and genetic structure between populations of Hesperis L. (Brassicaceae) species using molecular markers. - Genetika, Vol 53, No.2, 769-782. https://doi.org/10.2298/GENSR2102769M 12. Mowang S.-C., F.-J. Chen, Zeenat (2021). Study on genetic diversity between Erodium (Geranaiceae) species based on inter-simple sequence repeat markers- Genetika, Vol 53, No.2, 927-939. https://doi.org/10.2298/GENSR2102837M 13. Najafian S., I.Mehregan, A. Iranbakhsh, M. Assadi, S. Fici (2021). Species delimitation in Capparis (Capparaceae): morphological and molecular. - Genetika, Vol 53, No.2, 609-627. https://doi.org/10.2298/GENSR2102609N name mark red not autors of paper (corrigentdum) 14. Nikkhah M., S. Arbabian, A. Majd, F. Sharifnia (2022). Genetic diversity of Cordia myxa L. assessed by ISSR markers. - Genetika, Vol 54, No.1, 63-72. https://doi.org/10.2298/GENSR2201063N 15. Ou C., Z. Shen, Y. Liu, Z. Wang, M. Farshadfar (2021). Morphometric analysis and genetic diversity in Pistacia species populations using sequence related amplified polymorphism. - Genetika, Vol 53, No.3, 1193-1205 https://doi.org/10.2298/GENSR2103193O 16. Qian X. and S. Mehri (2021). Detecting DNA polymorphism and genetic diversity in a wide pistachio germplasm by RAPD markers- Genetika, Vol 53, No.2, 783-798 https://doi.org/10.2298/GENSR2102783Q 17. Xu P.,C. Xu, X.Huang, H.Wang, H. Morabbi Heravi (2021). Genetic diversity and genepool of Salicornia sinus-persica akhani based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1287 - 1296.https://doi.org/10.2298/GENSR2103287X 18. Garshasbi S., A. Iranbakhsh, Y. Asri, S. Z. Bostanabad (2021). Genetic diversity and population structure analysis in Lonicera L. (Caprifoliaceae) with the use of ISSR molecular markers. - Genetika, Vol 53, No.3, 1273 - 1286 https://doi.org/10.2298/GENSR2103273G name mark red not autors of paper (corrigentdum) 19. Sun Y., H. Jiang, F. Zeng, X. Pan, X. Wu, Y. Qi, X. Wu (2022). Species identification and genetic diversity of Alcea (Malvaceae) using SCOT molecular markers: medicinal plant. - Genetika, Vol 54, No.1, 369-378. https://doi.org/10.2298/GENSR2201369S 20. Ting S. and Y. Yibing (2022). Population differentiation and gene flow of Glaucium flavum (Papaveraceae). - Genetika, Vol 54, No.1, 275-288 https://doi.org/10.2298/GENSR2201275T 21. Xu P.,C. Xu, X.Huang, H.Wang, H. Morabbi Heravi (2021). Genetic diversity and genepool of Salicornia sinus-persica akhani based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1287 - 1296. https://doi.org/10.2298/GENSR2103287X 22. Yanpeng Z., W. Hongmei, L. Wei, M. Khayatnezhad, Faisal (2021). Genetic diversity and relationships among Salvia species by ISSR markers. - Genetika, Vol 53, No.2, 559-574. https://doi.org/10.2298/GENSR2102559Y 23. Yao X., R. Zhou, M.Farshadfar (2021). Comparison of individual based approaches using RAPD markers for identifying genetic relationships in Erodium (Geranaiceae)- Genetika, Vol 53, No.3, 1229 - 1238 https://doi.org/10.2298/GENSR2103229Y 24. Yin J. (2022). Evaluation of genetic variability Rindera using RAPD markers. - Genetika, Vol 54, No.1, 173-186. https://doi.org/10.2298/GENSR2201173Y 25. Zhang X. and A. Shakoor (2021). Strong genetic differentiation of the Paracaryum species (Boraginaceae) detected by inter-simple sequence repeats (ISSR).- Genetika, Vol 53, No.2, 883-894 https://doi.org/10.2298/GENSR2102883Z 26. Zhang Z., H. Yu, S. Feng, A. A. Minaeifar (2021). Species identification and population structure analysis in Hesperis L. (Brassicaceae). - Genetika, Vol 53, No.3, 1357 - 1368 https://doi.org/10.2298/GENSR2103357Z 27. Zhou Y. and Z. Zheng (2022). Genetic Diversity and inter-relationship among Stellaria L. (Caryophyllaceae) species ISSR markers. - Genetika, Vol 54, No.1, 119-130. https://doi.org/10.2298/GENSR2201119Z In addition, Clarivate provided the publisher with evidence of inappropriate manipulation of citations of five paper published in journal Genetika in journal Bioscenece research: 1. Bi D., D. Chen, M. Khayatnezhad, Z. S. Hashjin, Z. Li, Y. Ma (2021). Genetic response of growth phases for abiotic environmental stress tolerance in cereal crop plants. - Genetika, Vol 53, No.1,393-405 https://doi.org/10.2298/GENSR2101393B 2. Chen W., M. Khayatnezhad, N, Sarhadi (2021). Gene flow and population structure in Allochrusa (Caryophylloideae, caryophyllaceae) with the use of molecular markers- Genetika, Vol 53, No.2, 799-812 https://doi.org/10.2298/GENSR2102799C 3. Jia Y., M. Khayatnezhad, S. Mehri (2020). Population differentiation and gene flow in Erodium cicutarium: a potential medicinal plant- Genetika, Vol 52, No.3, 1127-1144. https://doi.org/10.2298/GENSR2003127J 4. Peng X., M. Khayyatnezhad and L. Joudi Ghezeljehmeidan (2021). RAPD profiling in detecting genetic variation in Stellaria L. (Caryophyllaceae).- Genetika, Vol 53, No.1,349 -362. https://doi.org/10.2298/GENSR2101349P 5. Yin J., M. Khayatnezhad, A. Shakoor (2021). Evaluation of genetic diversity in geranium (Geraniaceae) using RAPD marker.- Genetika, Vol 53, No.1,363 -378. https://doi.org/10.2298/GENSR2101363Y Authors who misused the papers published in Genetika by citing them unjustifiably as well as authors of the cited papers are barred from publishing in that journal in the future and will be blacklisted by the journal. We would like to apologize authors, readers and all scientific community that we are having to make those retractions, and we will take all necessary steps to ensure our editorial and peer review processes keep pace with the evolving threat and advancements in scientific fraud. Snezana Mladenovic Drinic, editor Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103179B">10.2298/GENSR2103179B</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102867H">10.2298/GENSR2102867H</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103081J">10.2298/GENSR2103081J</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102895L">10.2298/GENSR2102895L</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102739L">10.2298/GENSR2102739L</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103369L">10.2298/GENSR2103369L</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102507L">10.2298/GENSR2102507L</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103331L">10.2298/GENSR2103331L</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102651M">10.2298/GENSR2102651M</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102671M">10.2298/GENSR2102671M</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102769M">10.2298/GENSR2102769M</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102837M">10.2298/GENSR2102837M</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102609N">10.2298/GENSR2102609N</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2201063N">10.2298/GENSR2201063N</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103193O">10.2298/GENSR2103193O</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102783Q">10.2298/GENSR2102783Q</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103287X">10.2298/GENSR2103287X</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103273G">10.2298/GENSR2103273G</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2201369S">10.2298/GENSR2201369S</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2201275T">10.2298/GENSR2201275T</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102559Y">10.2298/GENSR2102559Y</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103229Y">10.2298/GENSR2103229Y</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2201173Y">10.2298/GENSR2201173Y</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102883Z">10.2298/GENSR2102883Z</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2103357Z">10.2298/GENSR2103357Z</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2201119Z">10.2298/GENSR2201119Z</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2101393B">10.2298/GENSR2101393B</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2102799C">10.2298/GENSR2102799C</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2003127J">10.2298/GENSR2003127J</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2101349P">10.2298/GENSR2101349P</a> Link to the retracted article <a href="http://dx.doi.org/10.2298/GENSR2101363Y">10.2298/GENSR2101363Y</a>

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Schulte, Stephanie. « Teachers in the UK Prefer Research Evidence that is Synthesized, Practical, and Locally Available ». Evidence Based Library and Information Practice 3, n^o 4 (3 décembre 2008) : 72. http://dx.doi.org/10.18438/b8r62d.

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A Review of: Williams, Dorothy and Louisa Coles. “Evidence-Based Practice in Teaching: An Information Perspective.” Journal of Documentation 63.6 (2007): 812-35. Objective – The objective of the study was to explore how teachers in the United Kingdom use research literature to inform their practice. Special emphasis was given to the effect of the teachers’ information literacy and their level of ready access to research information. Design – This study was primarily a qualitative study utilizing mixed methods, including individual interviews, focus groups (“literature review groups”), and an online discussion forum. Qualitative data was supplemented by a questionnaire survey. Setting – The qualitative portions of the study took place in the United Kingdom across five education authorities; however, it is unclear where these authorities were geographically. The survey was distributed across Scotland, England, and Wales. The study was conducted during 2002 to 2003. Subjects – Nursery, primary, and secondary teachers, school librarians, school library systems, and education authority advisors (EA) in the United Kingdom. Methods – The 28 interviews (54% primary teachers, 39% secondary teachers, 7% special education) and four focus groups (each with three to five participants; 15 participants in total, including teachers at various levels from primary, secondary, and nursery schools) were conducted with volunteers from a random sample across five education authorities. Recruitment was done by sending written materials to schools. Those interviewed represented five authorities. Focus groups were conducted in just four authorities. It is not clear when the individual and group interviews were conducted (time of day and year). Volunteers were given the option to receive funding for a substitute teacher in order to participate, though none took advantage of this offer. The interview process used a vignette technique to elicit teachers’ attitudes to a situation in a non-threatening way. Interviewees were asked to comment on two situations that might make them seek information. One was adding a new subject or new aspect of an existing subject into the classroom. The second dealt with a “new pedagogical challenge.” Though the topics of the vignettes were provided, the exact way the topics were presented was not. They were asked how they would advise another teacher in these situations then relate their thoughts to a real situation they had faced. Interviews were about one hour in length. Twenty-five of the 28 interviews were taped and transcribed verbatim. Extensive notes were made for the other three. Transcripts and notes were analyzed using QSR N4 Classic content analysis software. Themes related to information literacy and information seeking, including barriers, were noted. Four literature response groups were given examples of research information (journal articles, reports, etc) related to information computer technology (ICT) and class size. Each topic had information from various evidence levels and included both print and electronic format. Again, the discussion topics were provided in the article, but the exact way the topics were presented was not. Over 2 to 2.5 hours, teachers read the materials, made notes, and discussed the information as a group. For the ICT information, groups were asked to discuss presentation of the information. For the class size information, groups were asked to discuss content of the materials. Discussions were transcribed verbatim and analyzed with the content analysis software. A total of 3899 questionnaire surveys were distributed to teachers (3000), head teachers (500), school librarians (250), education authority advisors (100), and school library systems (49). Response rate was exceptionally low in the teacher and head teacher categories, with only 10.9% of teachers and 15.6% of head teachers responding. Response rates in other categories ranged from 31.2% to 55%, with the highest response rates from education authorities and school library systems. The survey served to gain an understanding of attitudes about using research in practice across a broad spectrum of stakeholders. The survey instrument itself, which was not provided in the article, was piloted prior to the study, but there is no mention of reliability or validity analysis. To supplement study data, participants who had stated they would be interested in participating in an online discussion were sent preliminary findings and asked to comment on themes using the online discussion forum. Only 21 posts were gathered using this method. Overall, the methods used in this study are appropriate for the questions that were posed in the article. Qualitative studies are useful for gathering data where little is known and where more data would help identify possibly hypotheses for further study. Main Results – Teachers in this study relied on a small set of resources and preferred what was readily available at their own school. These teachers most frequently used colleagues, in-service events, the Internet, newspapers, and reports typically found in schools as sources of information. Sources that information professionals would consider quality evidence were rarely mentioned. These teachers also tended to prefer sources that present information in a practical context. Not surprisingly, time was identified as a major barrier to accessing research information in addition to limited access to resources. The Internet was identified as the preferred point of access, citing ease of use, speed, and convenience as the reasons for this preference. Comments suggested a preference for synthesized information sources. Teachers indicated they felt the responsibility for disseminating research information fell on head teachers and EA. They also noted that access to information from their own school library was a problem. They felt librarians and libraries in schools were meant for students, not for teachers, and also expressed that school libraries typically did not provide access to research. Comments suggested that the structure of teaching in a classroom itself does not allow teachers to use information as is needed for evidence-based practice. There were concerns expressed about lack of school library funding available to supply research evidence needed by teachers. School librarians and school library services respondents did indicate that they provide a broad range of services aimed at teachers, such as alerts to literature, information skills training, and advice on resources. However, their sources of research for teachers were limited in nature. Librarians indicated that teachers did not ask for research information, but if demand were there, they could respond accordingly. Teacher comments suggest that librarians might want to consider being more proactive in distributing information. Though teachers expressed high confidence in their abilities to find information, comments about search habits and practices contradicted this. Most remarks suggested searching techniques that were not sophisticated or showing higher levels of information literacy competency. The respondents were concerned with evaluating the quality of information sources but found this appraisal to be more difficult if the authors did not explain the impact or change in practice that should come from the findings. The participants in this study were likely biased toward using research information more than other teachers. This is an important limitation that the authors do address. Additionally, the response rate for the survey was quite low for the teacher subset. Despite this limitation, data from the questionnaire was used appropriately to confirm and clarify data from the qualitative portions of the study. Conclusion – In order for teachers to appreciate the value of quality research evidence enough to regularly seek it out and place it into practice, a culture of evidence based practice must be embraced and supported by their school authorities. This study indicates significant potential for school librarians and systems to support this culture through proactive dissemination of research, provision of local access to materials, and education related to information literacy. School librarians must evolve from their typical student-centric role to accomplish this.

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Silva, Fátima Maria Rodrigues Chagas da, et Laélia Portela Moreira. « Professores iniciantes em escolas de periferia : desafios da “sobrevivência” na sala de aula (Beginning teachers in periphery schools : challenges of “survival” in the classroom) ». Revista Eletrônica de Educação 14 (9 octobre 2020) : 4183122. http://dx.doi.org/10.14244/198271994183.

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e4183122The beginning of the teaching practice is a phase of utmost importance for the constitution of the teacher's identity and it generally presents itself as being full of challenges. This article presents the results of a research that analyzed the main difficulties of the initial years of teaching, from the point of view of novice teachers teaching for the Municipality of Duque de Caxias (Brazil), complemented with testimonies of the pedagogical team. Concepts such as "Reality Shock" and "Professional Development" gave theoretical support to the research. The methodology included analysis of documents, questionnaires and interviews. The results made it possible to identify general challenges related to student learning, such as the work with literacy classes, students from integration programmes, difficulties in dealing with the diversity present in the classroom and also with the structural conditions of the system. The research made it possible to raise important aspects to be considered for in-service training, as well as reinforcing the need for integration policies for these teachers.ResumoO início da docência é uma fase de máxima importância para a constituição da identidade do professor e se apresenta, no geral, pleno de desafios. O artigo apresenta os resultados de uma pesquisa que analisou as principais dificuldades dos anos iniciais da docência, sob a ótica de professores iniciantes da Rede de Ensino do Município de Duque de Caxias, RJ, complementada com depoimentos da equipe pedagógica. Conceitos como “Choque de Realidade” e “Desenvolvimento Profissional” deram suporte teórico à pesquisa. A metodologia incluiu análise de documentos, questionários e entrevistas. Os resultados possibilitaram, além da identificação de desafios gerais relacionados à aprendizagem dos alunos, outros como, trabalho com turmas de alfabetização, com estudantes incluídos, dificuldades de lidar com a diversidade presente em sala de aula e ainda com as condições estruturais da Rede. A pesquisa favoreceu também o levantamento de aspectos importantes a serem considerados para a formação em serviço, bem como reforçou a necessidade de políticas de acolhimento a esses professores.Resumen El inicio de la docencia es una fase de máxima importancia para la constitución de la identidad del profesor y se presenta, en general, pleno de desafíos. El artículo presenta los resultados de una investigación que buscó analizar las principales dificultades de los años iniciales de la docencia, bajo la óptica de profesores iniciantes de la Red de Enseñanza del Municipio de Duque de Caxias, RJ (Brasil), complementada con testimonios del equipo pedagógico. Conceptos como "Choque de Realidad" y "Desarrollo Profesional" dieron soporte teórico a la investigación. La metodología incluyó análisis de documentos, cuestionarios y entrevistas. Los resultados posibilitar, además de la identificación de desafíos generales relacionados al aprendizaje de los alumnos, otros como, trabajo con grupos de alfabetización, con estudiantes incluidos, dificultades de lidiar con la diversidad presente en el aula y aún con las condiciones estructurales de la Red. La investigación favoreció también el levantamiento de aspectos importantes a ser considerados para la formación en servicio, así como reforzó la necesidad de políticas de acogida a esos profesores.Palavras chave: Profissão docente, Professor iniciante, Formação em serviço.Keywords: Teaching profession, Beginning teacher, In-service training.Palabras clave: Profesión docente. Profesor principiante. Formación en servicio.ReferencesANDRÉ, Marli. Políticas de valorização do trabalho docente no Brasil: algumas questões. Ensaio: Avaliação e. Políticas. Públicas em Educação, Rio de Janeiro, v. 23, n. 86, p. 213-230, jan./mar. 2015.BARDIN, Laurence. Análise de conteúdo. Lisboa: Edições 70, 1977.BEHRENS, Marilda Aparecida; FEDEL, Tiago Reus Barbosa. Os contributos da reflexão e da experiência vivenciada na formação continuada de professores. Revista Eletrônica de Educação, v. 14, 1-13, e3009045, jan./dez. 2020.BRASIL. Lei n. 9.394, de 20 de dezembro de 1996. Brasília, 1996. Disponível em: http://www.planalto.gov.br/ccivil_03/LEIS/l9394.htm. Acesso em: 2 abr. 2016.BRASIL. MEC-Ministério da Educação. O PNE - Plano Nacional de Educação (2014/2024) em Movimento. Disponível em: < http://pne.mec.gov.br/ >. Acesso em: 5 jun. 2016.CALIL, Ana Maria Gimenes Corrêa; ANDRÉ, Marli Eliza Dalmazo Afonso de. Uma política voltada para os professores iniciantes de Sobral-CE. Diálogo Educacional, Curitiba, v. 16, n. 50, p. 891-909, out./dez. 2016DUQUE DE CAXIAS. Prefeitura Municipal. Secretaria Municipal de Educação. PME-Plano Municipal de Educação da Rede Escolar de Duque de Caxias. Duque de Caxias, 2015. Disponível em: http://smeduquedecaxias.rj.gov.br/portalsme/cpfpf/wp-content/uploads/2017/10/PME-2015-2025-PARTE-I.pdfFERREIRO, Emilia. Reflexões sobre alfabetização. 21. ed. São Paulo: Cortez, 1993.GABARDO, Claudia Valéria Lopes. O início da docência no ensino fundamental na rede municipal de ensino. 2012. 127 f. Dissertação de Mestrado. UNIVILLE-Universidade da Região de Joinville. Joinville. 2012.GARCIA, Carlos Marcelo. Formação de Professores: para uma mudança educativa. Portugal: Porto, 1999.GARCIA, Carlos Marcelo. O professor iniciante, a prática pedagógica e o sentido da experiência. Formação Docente, Belo Horizonte, v. 2, n. 3, p. 11-49, ago./dez. 2010. Disponível em: http://formacaodocente.autenticaeditora.com.br < Acesso em: 13 jul. 2017.HUBERMAN, Michael. O ciclo de vida profissional dos professores. In: NÓVOA, António. (Org.). Vidas de professores. 2. ed. Portugal: Porto, cap. 2, p. 31-61, 2013.LEONE, Naiara Mendonça. A inserção no exercício da docência: necessidades formativas de professores em seus anos iniciais. São Paulo: Cultura Acadêmica, 2012. Disponível em: <http://culturaacademica.com.br/ img/arquivos/A_insercao_no_exercicio_da_docencia-Web_v2.pdf> Acesso em: 2 jan. 2018.MAGALHÃES, Lígia Karam Corrêa de; AZEVEDO, Leny Cristina Soares Souza. Formação continuada e suas implicações: entre a lei e o trabalho docente. Cadernos Cedes, Campinas, v. 35, n. 95, p. 15-36, jan./abr. 2015. Disponível em: <http://www.scielo.br/pdf/ccedes/ v35n95/0101-3262-ccedes-35-95-00015.pdf>. Acesso em: 20 mai. 2106.MARCELO, Carlos. Desenvolvimento profissional docente: passado e futuro. Sísifo, Revista de Ciências da Educação, n. 8, p. 7-22, jan./abr. 2009. Disponível em: < http://sisifo.ie.ulisboa.pt/index.php/sisifo/article/view/130>. Acesso em 2 jan. 2018.MIZUKAMI, Maria da Graça Nicoletti. Escola e desenvolvimento profissional da docência. In: GATTI, Bernardete Angelina et al. (Orgs.). Por uma política nacional de formação de professores. São Paulo: Unesp, p. 23-54, 2013.MORGADO, José Carlos. Identidade e profissionalidade docente: sentidos e (im) possibilidades. Ensaio: aval. pol. públ. Educ., Rio de Janeiro, v. 19, n. 73, p. 793-812, out./dez. 2011. Disponínel em http://www.redalyc.org/html/3995/399538139004/. Acesso em: 20 abr. 2018.NÓVOA, Antônio. Para uma formação de professores construída dentro da profissão. Revista de Educación, n. 350, septiembre/diciembre 2009. Texto em Português disponível em: < www.revistaeducacion.mec.es/re350_09.html.> . Acesso em abr. 2018.NÓVOA, Antônio. Os professores e o novo espaço público da educação. In: TARDIF, M.; LESSARD, C. (Org.). O ofício de professor: história, perspectivas e desafios internacionais. Petrópolis: Vozes, 2012. p. 213-229.NÓVOA, Antônio. Entrevista com o professor António Nóvoa. Educação em Perspectiva, Viçosa, v. 4, n. 1, p. 224-237, jan./jun. 2013. Disponível em: <http://www.seer.fv.br/seer/educacaoemperspectiva/index.php/ppgeufv/article/view/436/112>. Acesso em: 28 jan. 2017.PINTO, Joseane Amâncio. Professores iniciantes da Rede Municipal de Ensino São José dos Campos: inserção, desafios e necessidades. 2016. 162f. Dissertação de Mestrado. Universidade de Taubaté. 2016. Disponível em: <http://mpemdh.unitau.br/wp-content/uploads/2014/dissertacoes/mpe/Joseane-Amancio-Pinto.pdf> Acesso em: 10 jan. 2018.ROLDÃO, Maria do Céu Neves. Formação docente: natureza e construção do conhecimento profissional. Revista Brasileira de Educação, Rio de Janeiro, v. 12, n. 34, p. 94-103, jan./abr. 2007. Disponível em: <http://www.scielo.br/pdf/rbedu/v12n34/a08v1234.pdf>. Acesso em: 4 nov. 2017.ROMANOWSKI, Joana Paulin. Professores principiantes no Brasil: questões atuais. In: CONGRESSO INTERNACIONAL SOBRE PROFESSORADO PRINCIPIANTE E INSERCIÒN PROFESIONAL A LA DOCENCIA, 3, 2012, Santiago do Chile. Disponível em: <http://congressoprinc.com.br/artigo?id_artigo=195>. Acesso em: 20 set. 2017.ROMANOWSKI, Joana Paulin; MARTINS, Pura Lúcia Oliver. Desafios da formação de professores iniciantes. Páginas de Educación, Montevidéu, v. 6, n. 1, p. 81-94, jun. 2013. Disponível em: <http://www.scielo.edu.uy/pdf/pe/v6n1/v6n1a05.pdf >. Acesso em: 4 mar. 2017.SILVA, Vandré Gomes da; ALMEIDA, Patrícia Cristina Albieri de; GATTI, Bernardete Angelina. Referentes e critérios para a ação docente. Cadernos de Pesquisa, São Paulo, v. 46, n. 160, p. 286-311, abr./jun. 2016. Disponível em: <http://www.scielo.br/pdf/cp/v46n160/ 1980-5314-cp-46-160-00286.pdf>. Acesso em: 3 jun. 2017.

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TÜKENMEZ TİGEN, Elif, Buket ERTURK SENGEL, Canan CİMSİT, Hande PERK GURUN, Çiğdem APAYDIN KAYA et Volkan KORTEN. « Diagnostic performance between RT-PCR and chest CT in outpatients with clinically suspected COVID-19 ». Marmara Medical Journal, 3 août 2023. http://dx.doi.org/10.5472/marumj.1379916.

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Objective: To investigate the diagnostic performance between chest computed tomography (CT) and reverse transcription-polymerase chain reaction (RT-PCR) in outpatients with suspected coronavirus disease 2019 (COVID-19). Patients and Methods: Between March and June 2020, a total of 812 patients with clinically suspected COVID-19 who underwent both chest CT and initial-single RT-PCR on admission to outpatient units were retrospectively enrolled. CT severity-score (CT-SS) was calculated and data were matched with PCR results. Results: Of 812 patients, 54% (439/812) had positive RT-PCR results, and 47% (425/812) had a positive chest CT scan. With RT-PCR results as reference, the sensitivity, specificity, accuracy of chest CT in defining COVID-19 infection were 60%, (95% CI 56-65%, 265/439 patients), 57% (95% CI 52-62%, 213/373), 59% (95% CI 55-62%, 478/812), respectively. Three hundred eighty-seven (47%) patients had no CT findings, 380/812 (46.8%) had mild, 45/812 (5.5%) had moderate, and no patients in the severe group Conclusion: Chest CT did not show high sensitivity for the diagnosis of COVID-19 for outpatients. We suggest RT-PCR should be the primary diagnostic tool. Chest CT might be considered if there is a strong clinical suspicion with repeatedly negative RT-PCR test results, ensuring infection prevention and control measures can be preserved.

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Chew-Harris, J., S. Appleby, R. W. Troughton, A. M. Richards et C. J. Pemberton. « Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain ». European Heart Journal 41, Supplement_2 (1 novembre 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.1696.

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Abstract Background Soluble urokinase plasminogen activator receptor (suPAR) is an emerging biomarker of sub-inflammation related to plaque instability. Its modulation may reflect on immune dysfunction related to cardiovascular (CVD) outcomes. We assessed the prognostic performance of suPAR to predict 2-year clinical outcomes in patients with acute chest pain, suspicious of acute coronary syndromes. Methods A total of 812 patients presenting to the emergency department with the primary complaint of acute chest pain were prospectively recruited. Baseline suPAR concentrations were measured at presentation using the ViroGates CE-marked ELISA. Standard cardiac markers including hsTnT and NT-proBNP (both Roche) were also measured. Data for all biomarkers were treated as continuous and expressed as median [interquartile range (IQR)]. Statistical assessment was made using SPSS v25 (IBM). Groups were compared by Mann-Whitney U test/Spearman's rho. Prognostic performance of suPAR in comparison with hsTnT and NT-proBNP to predict the primary outcomes of new myocardial infarction (MI), new heart failure (HF), all cause readmission, and the composite of major adverse cardiac events (MACE) were assessed using binary logistic regression after the adjustment of traditional risk factors. Results In the entire chest pain cohort [median age: 63 yrs (IQR: 54–74), 34% female], 156/812 of patients had adjudicated AMI [STEMI (n=22)/NSTEMI (n=134)]. suPAR concentrations were found to be lower in males (Spearman's Rho, r=−0.17, P<0.0001) and in those with eGFR ≥60mL/min/1.73m2 (n=439) (r=−0.40, P<0.0001), but elevated in those older than 65 years (n=372) (r=0.55, P<0.0001). During the 2-year follow-up period, there were 54 fatalities, 287 recorded as having new CVD events, 46 diagnosed with new heart failure, 71 with new MI (66 NSTEMI/5 STEMI), 54 with new unstable angina, 126 patients classified with MACE and 190 patients who were readmitted into hospital within 1-year from presentation. In logistic regression analyses, the odds ratio (OR) of suPAR; 8.5 (95% CI:1.8–40.9) to predict a 2-year event (for example new total CVD events) was stronger than hsTnT; OR: 1.2 (95% CI: 0.9–1.5) and NT-proBNP; OR: 0.8 (95% CI:0.8–1.3) (P<0.0001) (Figure). Further, incorporation of baseline suPAR values into multivariate models for predicting events, such as MACE at 2-years (adjusted for age, gender and eGFR), resulted in an improvement in the C-statistic from 0.72 to 0.76. Conclusion In this acute chest pain cohort, suPAR concentrations are independent predictors of cardiovascular outcomes at 2 years. suPAR may add value in the risk assessment of patients with acute chest pain. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Health Research Council of New Zealand, National Heart Foundation of New Zealand

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Yang, Chengcheng, Wanqi Zhao, Huihui Chen, Yinhui Yao et Jingmin Zhang. « Cardiac adverse events associated with lacosamide : a disproportionality analysis of the FAERS database ». Scientific Reports 14, n^o 1 (13 juillet 2024). http://dx.doi.org/10.1038/s41598-024-67209-0.

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AbstractLacosamide was the first approved third-generation antiepileptic drug. However, real-world data regarding its adverse cardiac reactions in large samples still need to be completed. We evaluated the cardiac safety profile of lacosamide using the Food and Drug Administration Adverse Event Reporting System (FAERS). We performed disproportionality analysis computing reporting odds ratio (ROR) as a quantitative metric to assess the signal of lacosamide-related cardiac adverse events (AEs) from 2013 Q1 to 2022 Q4. The signal was considered significant when the lower limit of the 95% confidence interval (CI) of the ROR exceeded 1, and ≥ 5 AEs were reported. Serious and nonserious cases were compared by statistical analysis, and signals were further prioritized using a rating scale. A total of 812 cardiac AEs associated with lacosamide were identified, and 92 signals were detected, of which 17 AEs were significantly associated signals. The median time-to-onset (TTO) for moderate priority signals was 10 days, whereas for weak priority signals, it was 54 days. Notably, all cardiac AEs exhibited an early failing pattern, indicating the risk gradually decreasing. Based on the comprehensive analysis of the FAERS database and prioritization of cardiac AE signals, our research enhances the awareness among healthcare professionals regarding cardiac AEs associated with lacosamide.

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Yang, Min, Kailv Sun et Jianmin Chang. « Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus ». BioMedical Engineering OnLine 21, n^o 1 (1 août 2022). http://dx.doi.org/10.1186/s12938-022-01013-7.

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Abstract Background Vulvar lichen sclerosus (VLS) is one of the most common clinical manifestations of vulva. Thirteen percent of women have symptomatic vulvar diseases. The aim of this study is to investigate the expression profile of circular RNA (circRNAs) in vulvar lichen sclerosus, and to identify the underlying core genes of VLS. Methods We removed rRNA for sequencing, and screened the differentially expressed messenger RNA (mRNAs), long non-coding RNA (lncRNAs) and single-stranded circRNA in 20 groups of VLS tissues and 20 groups of healthy female vulvar skin tissues. Bioinformatics analysis was used to analyze its potential functions. Results A total of 2545 differentially expressed mRNAs were assessed in VLS patients, of which 1541 samples were up-regulated and 1004 samples were down-regulated. A total of 1453 differentially expressed lncRNAs were assessed, of which 812 samples were up-regulated and 641 samples were down-regulated. A total of 79 differentially expressed circRNAs were assessed, of which 54 were up-regulated and 25 were down-regulated. The differential expression of circRNAs was closely related to biological processes and molecular functions. The differences in circRNAs were mainly related to the “human T-cell leukemia virus 1 infection” signaling pathway and the “axon guidance” signaling pathway. Conclusion The profile of abnormal regulation of circRNA exists in VLS. According to biological informatics analysis, the dysregulation of circRNAs may be related to the pathogenesis and pathological process of VLS.

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Chew-Harris, J., S. Appleby, R. W. Troughton, A. M. Richards et C. J. Pemberton. « Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain ». European Heart Journal 41, Supplement_2 (1 novembre 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.1695.

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Abstract Background Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory protein associated with plaque instability. Its modulation may reflect on immune dysfunction related to cardiovascular disease burden. We describe the prognostic performance of suPAR in patients presenting with chest pain suspicious of acute myocardial infarction (AMI). Methods suPAR concentrations were measured at presentation using the ViroGates CE-marked ELISA in 812 patients with the primary complaint of acute chest pain. Standard cardiac markers including hsTnT and NT-proBNP (both Roche) were also measured. Data for all biomarkers were treated as continuous and expressed as median [interquartile range (IQR)]. Statistical assessment was made using SPSS v25 (IBM). Groups were compared by Mann-Whitney U test/Spearman's rho. Prognostic performance of suPAR was assessed using receiver operator curve (ROC) area under the curve (AUC), Cox-proportional hazards regression and Kaplan-Meier analyses. Results In this chest pain cohort [median age: 63 yrs (IQR: 54–74), 34% female], 156/812 of patients had adjudicated AMI [STEMI (n=22)/NSTEMI (n=134)]. Total all-cause mortality was 18% within 10 yrs. Although median suPAR concentrations were elevated in AMI patients versus all other diagnoses [3.2 ng/mL (IQR:2.4–4.3) vs 2.7 ng/mL (IQR:2.2–3.6) (P<0.0001)], it did not assist in AMI diagnosis (ROC-AUC=0.60). In the entire chest pain cohort, suPAR (AUC≥0.82) had comparable discrimination to that of NT-proBNP (AUC≥0.84) for the prediction of mortality within 2 yrs (n=52), 4 yrs (n=77) and 10 yrs (n=149), and was better than hsTnT (AUC≤0.70). Addition of suPAR improved the mortality ROC curve of NT-proBNP (0.84 to 0.87) and for hsTnT (0.70 to 0.81) for 2-yr death prediction (Figure). Alone, suPAR was the strongest predictor (AUC=0.77) of new unstable angina at 2-yrs (n=52). The fully adjusted hazard ratio (HR) using Cox models showed suPAR (HR: 1.2) and NT-proBNP (HR: 1.3) to be the only independent biomarkers associated with death at 4 and 10-yrs (P<0.0001). Stratification of baseline suPAR by Kaplan-Meier plots for all-cause mortality showed the highest tertile of suPAR, compared to the lowest, was associated with a HR of 5.7 and 5.1 for 4-yr and 10-yr death, respectively. Conclusion suPAR is a strong prognostic indicator of long-term mortality and its usage alongside current cardiac biomarkers may assist in the risk stratification of AMI patients. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Health Research Council of New Zealand, National Heart Foundation of New Zealand

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van der Zaag, Pieter Date, Stephanie Geurts, Romke Rozema, Inge H. F. Reininga et Baucke van Minnen. « Maxillofacial haemorrhagic symptoms in emergency department patients : impact of antithrombotics ». European Journal of Trauma and Emergency Surgery, 10 janvier 2024. http://dx.doi.org/10.1007/s00068-023-02428-0.

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Abstract Purpose To investigate the effect of antithrombotics on the occurrence of maxillofacial haemorrhagic symptoms, and to determine if these haemorrhagic symptoms are predictors of maxillofacial fractures. Method A prospective cohort study was conducted of consecutive patients with maxillofacial trauma who had been admitted to the emergency department of four hospitals in the Netherlands. This study compared five haemorrhagic symptoms (peri-orbital haematoma, raccoon eyes, epistaxis, subconjunctival ecchymosis, and intra-oral haematoma) between patients not-using (NUA) and using (UA) of antithrombotics, and whether these maxillofacial haemorrhagic symptoms served as predictors for maxillofacial fractures. Results Out of the 1005 patients, 812 (81%) belonged to the NUA group, and 193 (19%) to the UA group. UA patients exhibited higher frequencies of peri-orbital hematoma (54% vs. 39%, p < 0.001), raccoon eyes (10% vs. 5%, p = 0.01), and subconjunctival ecchymoses (16% vs. 7%, p < 0.001). In NUA, peri-orbital hematoma (OR = 2.5, p < 0.001), epistaxis (OR = 4.1, p < 0.001), subconjunctival ecchymosis (OR = 2.3, p = 0.02), and intra-oral hematoma (OR = 7.1, p < 0.001) were significant fracture predictors. Among UA, peri-orbital hematoma (OR = 2.2, p = 0.04), epistaxis (OR = 5.4, p < 0.001), subconjunctival ecchymosis (OR = 3.7, p = 0.008), and intra-oral hematoma (OR = 22.0, p < 0.001) were significant fracture predictors. Conclusion Maxillofacial haemorrhagic symptoms were observed more frequently in the UA group than in the NUA group. However, in both groups, maxillofacial haemorrhagic symptoms appear to be predictors of maxillofacial fractures. Caution is warranted in attributing these symptoms solely to antithrombotic use during emergency department assessments.

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Woodford, Sarah, Trisha Parmar, Emily Leong, Jiayue Zhong, Ju Lee Oei, Keiji Suzuki, Kishore Kumar et al. « International Online Survey on the Management of Patent Ductus Arteriosus ». Neonatology, 11 janvier 2024, 1–7. http://dx.doi.org/10.1159/000535121.

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Introduction: There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally. Materials and Methods: We surveyed PDA management practices in neonatal intensive care units using a pre-piloted web-based survey, which was distributed to perinatal societies in 31 countries. The survey was available online from March 2018 to March 2019. Results: There were 812 responses. The majority of clinicians (54%) did not have institutional protocols for PDA treatment, and 42% reported variable management within their own unit. Among infants <28 weeks (or <1,000 g), most clinicians (60%) treat symptomatically. Respondents in Australasia were more likely to treat PDA pre-symptomatically (44% vs. 18% all countries [OR 4.1; 95% CI 2.6–6.5; p < 0.001]), and respondents from North America were more likely to treat symptomatic PDA (67% vs. 60% all countries [OR 2.0; 95% CI 1.5–2.6; p < 0.001]). In infants ≥28 weeks (or ≥1,000 g), most clinicians (54%) treat symptomatically. Respondents in North America were more likely to treat PDAs in this group of infants conservatively (47% vs. 38% all countries [OR 2.3; 95% CI 1.7–3.2; p < 0.001]), and respondents from Asia were more likely to treat the PDA pre-symptomatically (21% vs. 7% all countries [OR 5.5; 95% CI 3.2–9.8; p < 0.001]). Discussion/Conclusion: There were marked international differences in clinical practice, highlighting ongoing uncertainty and a lack of consensus regarding PDA management. An international conglomeration to coordinate research that prioritises and addresses these areas of contention is indicated.

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Fabbri, Raffaella, Rossella Vicenti, Valentina Magnani, Roberto Paradisi, Mario Lima, Lucia De Meis, Stefania Rossi et al. « Ovarian tissue cryopreservation and transplantation : 20 years experience in Bologna University ». Frontiers in Endocrinology 13 (12 octobre 2022). http://dx.doi.org/10.3389/fendo.2022.1035109.

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ObjectiveTo report the 20-year experience in ovarian tissue cryopreservation (OTC) and ovarian tissue transplantation (OTT) of the Bologna clinical center (Bologna, Italy).DesignRetrospective cohort study.Patients1026 pediatrics and women aged between 2 and 38 years who underwent OTC and OTT between January 2002 to January 2022.ResultsOf the 1026 patients, 238 (22.8%) were pediatrics (≤ 17 years, Group 1) and 788 (77.2%) were adult women (range 18-38 years, Group 2). In Group 1, 184 (77.3%) patients had malignant diseases and 54 (22.7%) had non-malignant diseases. In Group 2, 746 (94.7%) patients had malignant diseases and 42 (5.3%) had non-malignant diseases. No real complications were observed during surgery. In all the samples analyzed most of the follicles were in the resting stage, while only a few follicles were growing. In both fresh and thawed samples, follicular density was higher in Group 1 than in Group 2 (p < 0.01). Regardless of age, good preservation of follicles and stroma was observed in fresh and thawed ovarian tissue by histological and immunohistochemical analyses (estrogen and progesterone receptors; Ki67 and Bcl2 markers; TUNEL). To date, out of 1026 total women, 812 (79.1%) had their tissue stored. Sixty-eight (6.6%) patients died from their primary disease. Twenty-four (2.3%) women performed 33 OTTs between December 2011 and January 2022. Restoration of menstruation was observed in 15 out of 17 menopausal women. Six pregnancies were achieved, two hesitated in abortion and four in the birth of healthy babies.ConclusionOTC is the only fertility preservation technique applicable in pre-pubertal/pediatrics and in adult patients when stimulation for oocytes/embryos cryopreservation is not possible. The reported data can help future patients and physicians in their discussions and decisions about the need and possibilities of preserving ovarian function.

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Kato, Hirotaka, Anupam B. Jena et Yusuke Tsugawa. « Patient mortality after surgery on the surgeon’s birthday : observational study ». BMJ, 10 décembre 2020, m4381. http://dx.doi.org/10.1136/bmj.m4381.

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Abstract Objective To determine whether patient mortality after surgery differs between surgeries performed on surgeons’ birthdays compared with other days of the year. Design Retrospective observational study. Setting US acute care and critical access hospitals. Participants 100% fee-for-service Medicare beneficiaries aged 65 to 99 years who underwent one of 17 common emergency surgical procedures in 2011-14. Main outcome measures Patient postoperative 30 day mortality, defined as death within 30 days after surgery, with adjustment for patient characteristics and surgeon fixed effects. Results 980 876 procedures performed by 47 489 surgeons were analyzed. 2064 (0.2%) of the procedures were performed on surgeons’ birthdays. Patient characteristics, including severity of illness, were similar between patients who underwent surgery on a surgeon’s birthday and those who underwent surgery on other days. The overall unadjusted 30 day mortality on the operating surgeon’s birthday was 7.0% (145/2064) and that on other days was 5.6% (54 824/978 812). After adjusting for patient characteristics and surgeon fixed effects (effectively comparing outcomes of patients treated by the same surgeon on different days), patients who underwent surgery on a surgeon’s birthday exhibited higher mortality compared with patients who underwent surgery on other days (adjusted mortality rate, 6.9% v 5.6%; adjusted difference 1.3%, 95% confidence interval 0.1% to 2.5%; P=0.03). Event study analysis of patient mortality by day of surgery relative to a surgeon’s birthday found similar results. Conclusions Among Medicare beneficiaries who underwent common emergency surgeries, those who received surgery on the surgeon’s birthday experienced higher mortality compared with patients who underwent surgery on other days. These findings suggest that surgeons might be distracted by life events that are not directly related to work.

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Rizzo, Stefania, Giorgio Raia, Maria Del Grande, Maria Luisa Gasparri, Ilaria Colombo, Lucia Manganaro, Andrea Papadia et Filippo Del Grande. « Body composition as a predictor of chemotherapy-related toxicity in ovarian cancer patients : A systematic review ». Frontiers in Oncology 12 (2 novembre 2022). http://dx.doi.org/10.3389/fonc.2022.1057631.

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ObjectivesThe main objective of this systematic review was to examine the literature evaluating association of image-based body composition with chemotherapy-related toxicity in ovarian cancer patients. A secondary objective was to evaluate the different definitions of sarcopenia across studies.MethodsThis systematic review was conducted according to the PRISMA-DTA statement and the protocol was registered on Prospero. A comprehensive literature search of 3 electronic databases was performed by two authors. For each eligible article, information was collected concerning the clinical setting; basic study data; population characteristics; technical aspects; body composition features; chemotherapy drugs administered; association of body composition values and toxicities. The overall quality of the included studies was critically evaluated.ResultsAfter the initial retrieval of 812 articles, the systematic review included 6 articles (5/6 studies were retrospective; one was prospective). The number of patients ranged between 69 and 239; mean/median age ranged between 55 and 65 years; the percentage of sarcopenic patients ranged between 25% and 54%. The cut-off values to define sarcopenia and the vertebral levels for evaluation of body composition were different. Five studies included chemotherapy based on carboplatin and paclitaxel, 1 included chemotherapy based on pegylated liposomal doxorubicin. Among the studies including carboplatin and paclitaxel, 3/5 demonstrated an association with toxicity, whereas 2/5 did not. Altogether, 4/6 papers demonstrated an association between the body composition values and the development of chemotherapy-related toxicities.ConclusionsThere is a wide variability of results about the association of body composition and chemotherapy-related toxicity in ovarian cancer patients. Therefore further studies, possibly including a comprehensive assessment of body compartments and where the definition of body composition cut-offs is constant, are warranted to better understand this association.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337753, identifier (CRD42022337753).

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Oppel, Steffen, Robert Eisler et Nik Aspey. « Population status of the endemic Pitcairn Reed Warbler Acrocephalus vaughani on Pitcairn Island, South Pacific ». Bird Conservation International 34 (2024). http://dx.doi.org/10.1017/s0959270923000370.

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Summary Reed warblers are widespread throughout Eurasia, Africa, and Australasia, and many species undertake long seasonal migrations. By contrast, other species of the genus Acrocephalus are sedentary and endemic to single oceanic islands. The Pitcairn Reed Warbler Acrocephalus vaughani is confined to the small volcanic island of Pitcairn in the South Pacific Ocean, and no population assessments have ever been conducted for this species. Due to its restricted range, the presence of invasive species, and the loss of natural habitat, the species is considered as globally “Endangered”, but its actual conservation status is entirely speculative. We conducted transect surveys and nest monitoring in the austral summer of 2022/23 and present abundance estimates for the species. We counted between 51 and 158 reed warblers along 54 transects that were each 100 m long and covered all habitats and roughly 13% of the vegetated island area. Using binomial mixture models accounting for imperfect detection and habitat variation in abundance, we estimated that Pitcairn may hold 1,568 (95% confidence interval 812–3,237) Pitcairn Reed Warblers, and that the species appeared to be most abundant in introduced Rose Apple Syzygium jambos stands. Based on the monitoring of 49 nests, of which only four failed to fledge any young, we estimated that Mayfield nest survival rate was 0.69 and estimated productivity was 1.07 (± 0.39 standard deviation) fledglings per nest. Assuming that Pitcairn Reed Warblers have similar annual survival probabilities as other island reed warblers, the productivity appears sufficient to maintain the population and there is no indication that the species has decreased significantly over the past three generations. Given the limited extent of occurrence, and the stable current population size between 442 and 2,774 mature individuals, we recommend that the global conservation status of the Pitcairn Reed Warbler be classified as “Vulnerable”.

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Chrisp, Georgina L., Maria Quartararo, David J. Torpy, Henrik Falhammar et R. Louise Rushworth. « Trends in hospital admissions for adrenal insufficiency in adolescents and young adults in the 21st century ». Frontiers in Endocrinology 13 (20 septembre 2022). http://dx.doi.org/10.3389/fendo.2022.986342.

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BackgroundVery little is known about the epidemiology of adrenal crises (AC) and adrenal insufficiency (AI) in adolescents and young adults.MethodsData on all admissions to Australian hospitals between 2000/1 to 2019/20 for a principal diagnosis of AI (including AC) in 10-24 year olds were extracted from a national repository. Age and sex-specific rates and age-adjusted rates were compared.FindingsOver the study, there were 3386 admissions for a principal diagnosis of AI; 24.0% (n=812) were for an AC and 50·7% (n=1718) were for secondary AI. Age-adjusted AI admissions increased from 31·70/million in 2000/1 to 54·68/million in 2019/20 (p<0·0001). Age-adjusted AC admissions also increased, most notably in the second decade (from 5·80/million in 2010/11 to 15·75/million in 2019/20) (p<0·00001). Average AI and AC admission rates were comparable between the sexes, but rates increased significantly in females, especially in those aged 20 to 24 years, whose AC rate in 2019/20 (39·65/million) was significantly higher than the corresponding rate in 2000/1 (3·15/million) (p<0·00001). Average age-adjusted SAI admission rates were higher in males (23·92/million) than females (15·47/million) (p<0·00001). However, SAI admission rates increased only among females (from 11·81/million to 22·12/million in 2019/20), with an increase in 20-24 year old females in the second decade from 5·07/million in 2010 to 20·42/million (p<0·00001). Age adjusted admissions for congenital adrenal hyperplasia, primary AI (PAI) and drug-induced AI did not change significantly over the study.InterpretationAC/AI admissions increased over the first two decades of this century in the emerging adult population, particularly among females who also experienced a marked increase in AC admission rates, most evident in the second decade. Although uncertain, possible explanations include: dose of glucocorticoid replacement; non-adherence to therapy; psychosocial factors; and difficulty in transition to adult services. Admissions for SAI also increased, while rates of PAI and CAH remained constant.

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Bolser, Donald, Tabitha Shen, Ivan Poliacek, Melanie Rose, M. Nicholas Musselwhite, Zuzana Kotmanova et Lukas Martvon. « Influence of Microinjection of Kynurenic acid into the Pre-Botzinger Complex on Swallowing in the Cat ». Physiology 39, S1 (mai 2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.1538.

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Recent evidence supports the involvement of the pre-BÖtzinger complex (pre-BOT) in spatiotemporal features of swallowing and swallowing-breathing coordination in mice. We hypothesized that pharmacological disruption of glutamate neurotransmission in this brainstem region would perturb the swallow motor pattern in anesthetized cats. Electromyograms (EMGs) of upper airway muscles were recorded in anesthetized, spontaneously breathing cats (n=5). Swallowing was induced by injection of 3 cc of water into the oropharynx. Multi-barrel micropipettes were employed to inject artificial cerebrospinal fluid or kynurenic acid (KYN; 50 mM, 44±3 nL per injection) bilaterally into the region of the pre-BOT. Microinjection sites were confirmed histologically by detection of fluorescent beads that were suspended in the microinjectate. Blocking glutamate-related neuronal excitation by bilateral microinjections of the nonspecific glutamate receptor antagonist kynurenic acid had no effect on the number of swallows induced by water injection (control 2.3±0.3; KYN 3.0±0.7; P<0.32). Swallow durations were significantly increased following microinjections of KYN from 691±54 ms to 812±81 ms (p<0.04). KYN significantly reduced the magnitudes of geniohyoid (control 97±3 % of median; Kyn 47±12% of control median, p<0.02), thyrohyoid (control 100±3% of median; KYN 69±8% of control median, p<0.01), and posterior cricoarytenoid (control 103±2% of median; KYN 74±8% of control median, p<0.04) muscle EMGs during swallowing. There was no significant effect of microinjection of KYN on the magnitudes of thyroartytenoid, mylohyoid, or thyropharyngeus electromyograms during swallowing. The results suggest that disruption of glutamate neurotransmission in the preBOT has preferential effects consistent with actions on motor drive to hypoglossal and ventrolateral motoneuron pools that participate in swallowing. Lengthening of swallow duration induced by KYN supports a role for the preBOT in modulating the excitability of the swallow oscillatory circuit. NIH HL163008; NIH HL 131716; HL 155721. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

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Nguyen, Steven, Weihua Guan, Jan Bressler, Megan Grove, Priya Palta, Rui Xia, Zhiying Wang et al. « Abstract P271 : Dna Methylation Measures of Aging in Midlife are Associated With Frailty Components in African American and European American Older Adults : The Atherosclerosis Risk in Communities (ARIC) Study ». Circulation 141, Suppl_1 (3 mars 2020). http://dx.doi.org/10.1161/circ.141.suppl_1.p271.

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Introduction: Several putative biomarkers of accelerated biological aging have been developed from patterns of DNA methylation in blood and other tissues (DNAm-Age scores). Some of these DNAm-Age scores have been found to be associated with age-related outcomes such as CVD and all-cause mortality, but their associations with frailty are unclear. We hypothesized that higher DNAm-Age scores measured in midlife are associated with higher odds of frailty and its components in late life. Methods: DNAm was measured at visit 2 or 3 in leukocyte DNA from 812 African American (AA) and 400 European American (EA) participants (mean age=54 years in AA, 57 years in EA), and was used to calculate three different DNAm-Age scores (Horvath, Hannum, and PhenoAge). Frailty status was assessed at visit 5, and dichotomized (frail/pre-frail or robust) using the following component criteria: slow walking speed, low grip strength, weight loss, low physical activity, and exhaustion. Logistic regression tested the associations of DNAm-Age scores, as the predictors of frailty status or each frailty component. Model 1 adjusted for visit 2 or 3 age, sex, education, white blood cell count, cell type proportions, and technical variables and model 2 additionally adjusted for BMI, smoking, alcohol, and visit 5 CHD, stroke, hypertension, and T2D. Inverse probability weights accounted for cohort attrition prior to frailty assessment. The Bonferroni-corrected threshold for statistical significance was set to p<8.3E-3 (0.05/6). Results: In African American participants, a 4-year increase in the PhenoAge score in midlife was associated with frailty in late life (OR=1.21, 95% CI=1.09, 1.35, p=3E-4) in model 1, which was attenuated in model 2 (OR=1.13, 95% CI=1.02, 1.26, p=2.4E-2), and with physical activity (model 2 OR=1.32, 95% CI=1.13-1.53, p=4E-4); a 4-year increase in the Hannum score was associated with the exhaustion and grip strength components (OR=1.33, 95% CI=1.13-1.57, p=6E-4; OR=1.38, 95% CI=1.16-1.64, p=3E-4, respectively). In European American participants, the DNAm-Age scores were not associated with frailty however a 4-year increase in both the Horvath and Hannum scores was associated with the weight loss component (model 2 OR=1.56, 95% CI=1.20-2.02, p=9E-4; OR=2.37, 95% CI=1.49-3.76, p=2E-4), respectively. Conclusions: In African American ARIC participants, a higher mid-life PhenoAge score was associated with higher odds of frailty/pre-frailty in late life, consistent with accelerated biological aging, but was not significant after further adjustment. The Horvath, Hannum, and PhenoAge scores were associated with some frailty components in African American and European American ARIC participants, consistent with accelerated biological aging. Following replication, future studies should examine the causal relationship between DNAm-Age, frailty, and frailty components.

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Zhan, Yang, Matthias G. Friedrich, Nandini Dendukuri, Yang Lu, Michael Chetrit, Ian Schiller, Lawrence Joseph et al. « Meta-Analysis of Normal Reference Values for Right and Left Ventricular Quantification by Cardiovascular Magnetic Resonance ». Circulation : Cardiovascular Imaging 17, n^o 2 (février 2024). http://dx.doi.org/10.1161/circimaging.123.016090.

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BACKGROUND: Cardiovascular magnetic resonance (CMR) reference values are relied upon to accurately diagnose left ventricular (LV) and right ventricular (RV) pathologies. To date, reference values have been derived from modest sample sizes with limited patient diversity and attention to 1 but not both commonly used tracing techniques for papillary muscles and trabeculations. We sought to overcome these limitations by meta-analyzing normal reference values for CMR parameters stemming from multiple countries, vendors, analysts, and patient populations. METHODS: We comprehensively extracted published and unpublished data from studies reporting CMR parameters in healthy adults. A steady-state free-precession short-axis stack at 1.5T or 3T was used to trace either counting the papillary muscles and trabeculations in the LV volume or mass. We used a novel Bayesian hierarchical meta-analysis model to derive the pooled lower and upper reference values for each CMR parameter. Our model accounted for the expected differences between tracing techniques by including informative prior distributions from a large external data set. RESULTS: A total of 254 studies from 25 different countries were systematically reviewed, representing 12 812 healthy adults, of which 52 were meta-analyzed. For LV parameters counting papillary muscles and trabeculations in the LV volume, pooled normative reference ranges in men and women, respectively, were as follows: LV ejection fraction of 52% to 73% and 54% to 75%, LV end-diastolic volume index of 60 to 109 and 56 to 96 mL/m 2 , LV end-systolic volume index of 18 to 45 and 16 to 38 mL/m 2 , and LV mass index of 41 to 76 and 33 to 57 g/m 2 . For LV parameters counting papillary muscles and trabeculations in the LV mass, pooled normative reference ranges in men and women, respectively, were as follows: LV ejection fraction of 57% to 74% and 57% to 75%, LV end-diastolic volume index of 60 to 97 and 55 to 88 mL/m 2 , LV end-systolic volume index of 18 to 37 and 15 to 34 mL/m 2 , and LV mass index of 50 to 83 and 38 to 65 g/m 2 . For RV parameters, pooled normative reference ranges in men and women, respectively, were as follows: RV ejection fraction of 47% to 68% and 49% to 71%, RV end-diastolic volume index of 64 to 115 and 57 to 99 mL/m 2 , RV end-systolic volume index of 23 to 52 and 18 to 42 mL/m 2 , and RV mass index of 14 to 29 and 13 to 25 g/m 2 . CONCLUSIONS: Our Bayesian hierarchical meta-analysis provides normative reference values for CMR parameters of LV and RV size, systolic function, and mass, encompassing both tracing techniques across a diverse multinational sample of healthy men and women.

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SALING, JARROD, ALEXANDRA L. MIGDAL, MARIA A. URRUTIA, ZOHYRA ZABALA, BOBAK MOAZZAMI, RODOLFO J. GALINDO, MAYA FAYFMAN, AMMAR A. RASHIED et GUILLERMO UMPIERREZ. « 812-P : Tight vs. Standard Inpatient Glycemic Targets in Non–Critical Care Settings—A Propensity Scored–Matched Analysis of Insulin-Treated Patients with Type 2 Diabetes ». Diabetes 72, Supplement_1 (20 juin 2023). http://dx.doi.org/10.2337/db23-812-p.

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Differing blood glucose (BG) targets are recommended by professional organizations in noncritical care settings. Previous Endocrine Society and ADA guidelines recommended a target BG of 70-140 and 140-180 mg/dl; however, the 2023 ADA Standards of Care recommends a target of 100-180 mg/dl. The lack of consensus is due to the lack of randomized clinical trials (RTC) to support a tight vs relaxed BG target. We performed a post-hoc analysis on 9 RCTs to assess hospital outcomes in non-critically ill insulin-treated subjects with T2D targeting BG 70-140 mg/dL vs. 140-180 mg/dL. Among 1446 patients, 640 were treated to a target of 70-140 mg/dl and 806 to a target of 140-180 mg/dL. Propensity score matching was used to reduce the bias including sex, HbA1c, and home insulin use, for a final count of 1,146 patients (573 subjects in each target group). Patients in the tight BG target group had lower mean BG (163.73±39.79 vs 170.15±39.94 mg/dL, p=0.004), less hyperglycemia (BG >180: 86% vs 92%, p=0.003; BG >240: 51% vs 62%, p<.001), similar rates of hypoglycemia (BG <70: 12% vs 15%, p=0.11; BG <54: 2.5% vs 4.0%, p=0.14). The intensive target resulted in a shorter length of stay (4.0 vs 6.0 days, p<.001) and lower composite of complication rate (acute kidney injury, infection, myocardial infarction, respiratory failure and stroke) (3.7% vs 6.8%, p=0.02) than the relaxed BG target, with similar mortality rates (0.9% vs 0.3%, p=0.36). There were no differences in glycemic variability (GV) between groups with greater GV in those experiencing hypoglycemia <70 mg/dL or hyperglycemia >200 mg/dL. Our results indicate that lower BG target of 70-140 mg/dl leads to lower mean daily BG, less severe hyperglycemia events, similar rates of hypoglycemia and glycemic variability, and lower length of stay and complication rates compared to a higher target of 140-180 mg/dl. RCTs are indicated to elucidate optimal glycemic targets in hospitalized patients with T2D. Disclosure J.Saling: None. A.L.Migdal: None. M.A.Urrutia: None. Z.Zabala: None. B.Moazzami: None. R.J.Galindo: Consultant; Novo Nordisk, Eli Lilly and Company, Sanofi, Pfizer Inc., Bayer Inc., WW (Weight Watchers), Research Support; Novo Nordisk, Eli Lilly and Company, Dexcom, Inc. M.Fayfman: None. A.A.Rashied: None. G.Umpierrez: Research Support; Abbott, Dexcom, Inc., Baxter. Funding Jacob Family Funds

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Chavdarov, Anatoliy V. « Special Issue No. – 10, June, 2020 Journal > ; Special Issue > ; Special Issue No. – 10, June, 2020 > ; Page 5 “Quantative Methods in Modern Science” organized by Academic Paper Ltd, Russia MORPHOLOGICAL AND ANATOMICAL FEATURES OF THE GENUS GAGEA SALISB., GROWING IN THE EAST KAZAKHSTAN REGION Authors : Zhamal T. Igissinova,Almash A. Kitapbayeva,Anargul S. Sharipkhanova,Alexander L. Vorobyev,Svetlana F. Kolosova,Zhanat K. Idrisheva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00041 Abstract : Due to ecological preferences among species of the genus GageaSalisb, many plants are qualified as rare and/or endangered. Therefore, the problem of rational use of natural resources, in particular protection of early spring plant species is very important. However, literary sources analysis only reveals data on the biology of species of this genus. The present research,conducted in the spring of 2017-2019, focuses on anatomical and morphological features of two Altai species : Gagealutea and Gagea minima ; these features were studied, clarified and confirmed by drawings and photographs. The anatomical structure of the stem and leaf blade was studied in detail. The obtained research results will prove useful for studies of medicinal raw materials and honey plants. The aforementioned species are similar in morphological features, yet G. minima issmaller in size, and its shoots appear earlier than those of other species Keywords : Flora,gageas,Altai species,vegetative organs., Refference : I. Atlas of areas and resources of medicinal plants of Kazakhstan.Almaty, 2008. II. Baitenov M.S. Flora of Kazakhstan.Almaty : Ġylym, 2001. III. DanilevichV. G. ThegenusGageaSalisb. of WesternTienShan. PhD Thesis, St. Petersburg,1996. IV. EgeubaevaR.A., GemedzhievaN.G. The current state of stocks of medicinal plants in some mountain ecosystems of Kazakhstan.Proceedings of the international scientific conference ‘”Results and prospects for the development of botanical science in Kazakhstan’, 2002. V. Kotukhov Yu.A. New species of the genus Gagea (Liliaceae) from Southern Altai. Bot. Journal.1989;74(11). VI. KotukhovYu.A. ListofvascularplantsofKazakhstanAltai. Botan. Researches ofSiberiaandKazakhstan.2005;11. VII. KotukhovYu. The current state of populations of rare and endangered plants in Eastern Kazakhstan. Almaty : AST, 2009. VIII. Kotukhov Yu.A., DanilovaA.N., AnufrievaO.A. Synopsisoftheonions (AlliumL.) oftheKazakhstanAltai, Sauro-ManrakandtheZaisandepression. BotanicalstudiesofSiberiaandKazakhstan. 2011;17 : 3-33. IX. Kotukhov, Yu.A., Baytulin, I.O. Rareandendangered, endemicandrelictelementsofthefloraofKazakhstanAltai. MaterialsoftheIntern. scientific-practical. conf. ‘Sustainablemanagementofprotectedareas’.Almaty : Ridder, 2010. X. Krasnoborov I.M. et al. The determinant of plants of the Republic of Altai. Novosibirsk : SB RAS, 2012. XI. Levichev I.G. On the species status of Gagea Rubicunda. Botanical Journal.1997;6:71-76. XII. Levichev I.G. A new species of the genus Gagea (Liliaceae). Botanical Journal. 2000;7 : 186-189. XIII. Levichev I.G., Jangb Chang-gee, Seung Hwan Ohc, Lazkovd G.A.A new species of genus GageaSalisb.(Liliaceae) from Kyrgyz Republic (Western Tian Shan, Chatkal Range, Sary-Chelek Nature Reserve). Journal of Asia-Pacific Biodiversity.2019 ; 12 : 341-343. XIV. Peterson A., Levichev I.G., Peterson J. Systematics of Gagea and Lloydia (Liliaceae) and infrageneric classification of Gagea based on molecular and morphological data. Molecular Phylogenetics and Evolution.2008 ; 46. XV. Peruzzi L., Peterson A., Tison J.-M., Peterson J. Phylogenetic relationships of GageaSalisb.(Liliaceae) in Italy, inferred from molecular and morphological data matrices. Plant Systematics and Evolution ; 2008 : 276. XVI. Rib R.D. Honey plants of Kazakhstan. Advertising Digest, 2013. XVII. Scherbakova L.I., Shirshikova N.A. Flora of medicinal plants in the vicinity of Ust-Kamenogorsk. Collection of materials of the scientific-practical conference ‘Unity of Education, Science and Innovation’. Ust-Kamenogorsk : EKSU, 2011. XVIII. syganovA.P. PrimrosesofEastKazakhstan. Ust-Kamenogorsk : EKSU, 2001. XIX. Tsyganov A.P. Flora and vegetation of the South Altai Tarbagatay. Berlin : LAP LAMBERT,2014. XX. Utyasheva, T.R., Berezovikov, N.N., Zinchenko, Yu.K. ProceedingsoftheMarkakolskStateNatureReserve. Ust-Kamenogorsk, 2009. XXI. Xinqi C, Turland NJ. Gagea. Flora of China.2000;24 : 117-121. XXII. Zarrei M., Zarre S., Wilkin P., Rix E.M. Systematic revision of the genus GageaSalisb. (Liliaceae) in Iran.BotJourn Linn Soc.2007;154. XXIII. Zarrei M., Wilkin P., Ingroille M.J., Chase M.W. A revised infrageneric classification for GageaSalisb. (Tulipeae ; Liliaceae) : insights from DNA sequence and morphological data.Phytotaxa.2011:5. View | Download INFLUENCE OF SUCCESSION CROPPING ON ECONOMIC EFFICIENCY OF NO-TILL CROP ROTATIONS Authors : Victor K. Dridiger,Roman S. Stukalov,Rasul G. Gadzhiumarov,Anastasiya A. Voropaeva,Viktoriay A. Kolomytseva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00042 Abstract : This study was aimed at examining the influence of succession cropping on the economic efficiency of no-till field crop rotations on the black earth in the zone of unstable moistening of the Stavropol krai. A long-term stationary experiment was conducted to examine for the purpose nine field crop rotation patterns different in the number of fields (four to six), set of crops, and their succession in crop rotation. The respective shares of legumes, oilseeds, and cereals in the cropping pattern were 17 to 33, 17 to 40, and 50 to 67 %. It has been established that in case of no-till field crop cultivation the economic efficiency of plant production depends on the set of crops and their succession in rotation. The most economically efficient type of crop rotation is the soya-winter wheat-peas-winter wheat-sunflower-corn six-field rotation with two fields of legumes : in this rotation 1 ha of crop rotation area yields 3 850 grain units per ha at a grain unit prime cost of 5.46 roubles ; the plant production output return and profitability were 20,888 roubles per ha and 113 %, respectively. The high production profitabilities provided by the soya-winter wheat-sunflower four-field and the soya-winter-wheat-sunflower-corn-winter wheat five-field crop rotation are 108.7 and 106.2 %, respectively. The inclusion of winter wheat in crop rotation for two years in a row reduces the second winter wheat crop yield by 80 to 100 %, which means a certain reduction in the grain unit harvesting rate to 3.48-3.57 thousands per ha of rotation area and cuts the production profitability down to 84.4-92.3 %. This is why, no-till cropping should not include winter wheat for a second time Keywords : No-till technology,crop rotation,predecessor,yield,return,profitability, Refference : I Badakhova G. Kh. and Knutas A. V., Stavropol Krai : Modern Climate Conditions [Stavropol’skiykray : sovremennyyeklimaticheskiyeusloviya]. Stavropol : SUE Krai Communication Networks, 2007. II Cherkasov G. N. and Akimenko A. S. Scientific Basis of Modernization of Crop Rotations and Formation of Their Systems according to the Specializations of Farms in the Central Chernozem Region [Osnovy moderniz atsiisevooborotoviformirovaniyaikh sistem v sootvetstvii so spetsi-alizatsiyeykhozyaystvTsentral’nogoChernozem’ya]. Zemledelie. 2017 ; 4 : 3-5. III Decree 330 of July 6, 2017 the Ministry of Agriculture of Russia “On Approving Coefficients of Converting to Agricultural Crops to Grain Units [Ob utverzhdeniikoeffitsiyentovperevoda v zernovyyee dinitsysel’s kokhozyaystvennykhkul’tur]. IV Dridiger V. K., About Methods of Research of No-Till Technology [O metodikeissledovaniytekhnologii No-till]//Achievements of Science and Technology of AIC (Dostizheniyanaukiitekhniki APK). 2016 ; 30 (4) : 30-32. V Dridiger V. K. and Gadzhiumarov R. G. Growth, Development, and Productivity of Soya Beans Cultivated On No-Till Technology in the Zone of Unstable Moistening of Stavropol Region [Rost, razvitiyeiproduktivnost’ soiprivozdelyvaniipotekhnologii No-till v zone ne-ustoychivog ouvlazhneniyaStavropol’skogokraya]//Oil Crops RTBVNIIMK (Maslichnyyekul’turyNTBVNIIMK). 2018 ; 3 (175) : 52–57. VI Dridiger V. K., Godunova E. I., Eroshenko F. V., Stukalov R. S., Gadzhiumarov, R. G., Effekt of No-till Technology on erosion resistance, the population of earthworms and humus content in soil (Vliyaniyetekhnologii No-till naprotivoerozionnuyuustoychivost’, populyatsiyudozhdevykhcherveyisoderzhaniyegumusa v pochve)//Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018 ; 9 (2) : 766-770. VII Karabutov A. P., Solovichenko V. D., Nikitin V. V. et al., Reproduction of Soil Fertility, Productivity and Energy Efficiency of Crop Rotations [Vosproizvodstvoplodorodiyapochv, produktivnost’ ienergeticheskayaeffektivnost’ sevooborotov]. Zemledelie. 2019 ; 2 : 3-7. VIII Kulintsev V. V., Dridiger V. K., Godunova E. I., Kovtun V. I., Zhukova M. P., Effekt of No-till Technology on The Available Moisture Content and Soil Density in The Crop Rotation [Vliyaniyetekhnologii No-till nasoderzhaniyedostupnoyvlagiiplotnost’ pochvy v sevoob-orote]// Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2017 ; 8 (6) : 795-99. IX Kulintsev V. V., Godunova E. I., Zhelnakova L. I. et al., Next-Gen Agriculture System for Stavropol Krai : Monograph [SistemazemledeliyanovogopokoleniyaStavropol’skogokraya : Monogtafiya]. Stavropol : AGRUS Publishers, Stavropol State Agrarian University, 2013. X Lessiter Frank, 29 reasons why many growers are harvesting higher no-till yields in their fields than some university scientists find in research plots//No-till Farmer. 2015 ; 44 (2) : 8. XI Rodionova O. A. Reproduction and Exchange-Distributive Relations in Farming Entities [Vosproizvodstvoiobmenno-raspredelitel’nyyeotnosheniya v sel’skokhozyaystvennykhorganizatsiyakh]//Economy, Labour, and Control in Agriculture (Ekonomika, trud, upravleniye v sel’skomkhozyaystve). 2010 ; 1 (2) : 24-27. XII Sandu I. S., Svobodin V. A., Nechaev V. I., Kosolapova M. V., and Fedorenko V. F., Agricultural Production Efficiency : Recommended Practices [Effektivnost’ sel’skokhozyaystvennogoproizvodstva (metodicheskiyerekomendatsii)]. Moscow : Rosinforagrotech, 2013. XIII Sotchenko V. S. Modern Corn Cultivation Technologies [Sovremennayatekhnologiyavozdelyvaniya]. Moscow : Rosagrokhim, 2009. View | Download DEVELOPMENT AND TESTING OF AUTONOMOUS PORTABLE SEISMOMETER DESIGNED FOR USE AT ULTRALOW TEMPERATURES IN ARCTIC ENVIRONMENT Authors : Mikhail A. Abaturov,Yuriy V. Sirotinskiy, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00043 Abstract : This paper is concerned with solving one of the issues of the general problem of designing geophysical equipment for the natural climatic environment of the Arctic. The relevance of the topic has to do with an increased global interest in this region. The paper is aimed at considering the basic principles of developing and the procedure of testing seismic instruments for use at ultralow climatic temperatures. In this paper the indicated issue is considered through the example of a seismic module designed for petroleum and gas exploration by passive seismoacoustic methods. The seismic module is a direct-burial portable unit of around 5 kg in weight, designed to continuously measure and record microseismic triaxial orthogonal (ZNE) noise in a range from 0.1 to 45 Hz during several days in autonomous mode. The functional chart of designing the seismic module was considered, and concrete conclusions were made for choosing the necessary components to meet the ultralow-temperature operational requirements. The conclusions made served for developing appropriate seismic module. In this case, the components and tools used included a SAFT MP 176065 xc low-temperature lithium cell, industrial-spec electronic component parts, a Zhaofeng Geophysical ZF-4.5 Chinese primary electrodynamic seismic sensor, housing seal parts made of frost-resistant silicone materials, and finely dispersed silica gel used as water-retaining sorbent to avoid condensation in the housing. The paper also describes a procedure of low-temperature collation tests at the lab using a New Brunswick Scientific freezing plant. The test results proved the operability of the developed equipment at ultralow temperatures down to -55°C. In addition, tests were conducted at low microseismic noises in the actual Arctic environment. The possibility to detect signals in a range from 1 to 10 Hz at the level close to the NLNM limit (the Peterson model) has been confirmed, which allows monitoring and exploring petroleum and gas deposits by passive methods. As revealed by this study, the suggested approaches are efficient in developing high-precision mobile seismic instruments for use at ultralow climatic temperatures. The solution of the considered instrumentation and methodical issues is of great practical significance as a constituent of the generic problem of Arctic exploration. Keywords : Seismic instrumentation,microseismic monitoring,Peterson model,geological exploration,temperature ratings,cooling test, Refference : I. AD797 : Ultralow Distortion, Ultralow Noise Op Amp, Analog Devices, Inc., Data Sheet (Rev. K). Analog Devices, Inc. URL : https://www.analog.com/media/en/technical-documentation/data-sheets/AD797.pdf(Date of access September 2, 2019). II. Agafonov, V. M., Egorov, I. V., and Shabalina, A. S. Operating Principles and Technical Characteristics of a Small-Sized Molecular–Electronic Seismic Sensor with Negative Feedback [Printsipyraboty I tekhnicheskiyekharakteristikimalogabaritnogomolekulyarno-elektronnogoseysmodatchika s otritsatel’noyobratnoysvyaz’yu]. SeysmicheskiyePribory (Seismic Instruments). 2014 ; 50 (1) : 1–8. DOI : 10.3103/S0747923914010022. III. Antonovskaya, G., Konechnaya, Ya.,Kremenetskaya, E., Asming, V., Kvaema, T., Schweitzer, J., Ringdal, F. Enhanced Earthquake Monitoring in the European Arctic. Polar Science. 2015 ; 1 (9) : 158-167. IV. Anthony, R. E., Aster, R. C., Wiens, D., Nyblade, Andr., Anandakrishnan, Sr., Huerta, Audr., Winberry, J. P., Wilson, T., and Rowe, Ch. The Seismic Noise Environment of Antarctica. Seismological Research Letters. 2015 ; 86(1) : 89-100. DOI : 10.1785/0220150005 V. Brincker, R., Lago, T. L., Andersen, P., and Ventura, C. Improving the Classical Geophone Sensor Element by Digital Correction. In Conference Proceedings : IMAC-XXIII : A Conference & ; Exposition on Structural Dynamics Society for Experimental Mechanics, 2005. URL : https://www.researchgate.net/publication/242452637_Improving_the_Classical_Geophone_Sensor_Element_by_Digital_Correction(Date of access September 2, 2019). VI. Bylaw 164 of the State Committee for Construction of the Russian Federation “On adopting amendments to SNiP 31-01-99 “Construction climatology”. URL : https://base.garant.ru/2322381/(Date of access September 2, 2019). VII. Chao Xu, Junbo Wang, Deyong Chen, Jian Chen, Bowen Liu, Wenjie Qi, XichenZheng, Hua Wei, Guoqing Zhang. The Electrochemical Seismometer Based on a Novel Designed.Sensing Electrode for Undersea Exploration. 20th International Conference on Solid-State Sensors, Actuators and Microsystems &Eurosensors XXXIII (TRANSDUCERS &EUROSENSORS XXXIII). IEEE, 2019. DOI : 10.1109/TRANSDUCERS.2019.8808450. VIII. Chebotareva, I. Ya. New algorithms of emission tomography for passive seismic monitoring of a producing hydrocarbon deposit : Part I. Algorithms of processing and numerical simulation [Novyye algoritmyemissionnoyto mografiidlyapassivnogoseysmicheskogomonitoringarazrabatyvayemykhmestorozhdeniyuglevodorodov. Chast’ I : Algoritmyobrabotki I chislennoyemodelirovaniye]. FizikaZemli. 2010 ; 46(3):187-98. DOI : 10.1134/S106935131003002X IX. Danilov, A. V. and Konechnaya, Ya. V. Analytical comparison of seismic instruments for stationary surveys in the Arctic [Sravnitel’nyyanalizseysmicheskoyapparaturydlyastatsionarnykhnablyudeniy v Arktike]. DSYS. URL : https://dsys.ru/upload/id254_docPDF_FranzJosefLand.pdf(Date of access September 2, 2019). X. Dew point temperature calculator. Maple Tech. International LLC. URL : https://www.calculator.net/dew-point-calculator.html?airtemperature=20&airtemperatureunit=celsius&humidity=0.34&dewpoint=&dewpointunit=celsius&x=51&y=14(Date of access September 2, 2019). XI. Frolov, A. S. Matching of wave fields recorded by different geophysical receivers [Soglasovaniyevolnovykhpoley, poluchennykh s primeneniyemrazlichnoyregistriruyushcheyapparatury]. Abstracts IX International scientific and technical conference competition of young specialists “Geophysics-2013”. Saint-Petersburg : Gubkin University, 2013. URL : https://www.gubkin.ru/faculty/geology_and_geophysics/chairs_and_departments/exploration_geophysics_and_computers_systems/files/2013_SPb_Frolov.pdf. (Date of access September 2, 2019). XII. Gibbons, S. J., Asming, V., Fedorov, A., Fyen, J., Kero, J., Kozlovskaya, E., Kværna, T., Liszka, L., Näsholm, S.P., Raita, T., Roth, M., Tiira, T., Vinogradov, Yu. The European Arctic : A laboratory for seismoacoustic studies. Seism. Res. Letters. 2015 ; 86 (3) : 917–928. XIII. GOST 8.395-80. State system for ensuring the uniformity of measurements. Reference conditions of measurements while calibrating. General requirements [Gosudarstvennayasistemaobespecheniyaedinstvaizmereniy. Normal’nyyeusloviyaizmereniypripoverke. Obshchiyetrebovaniya]. Moscow : Standartinform, 2008. URL : http://gostrf.com/normadata/1/4294821/4294821960.pdf (Date of access September 2, 2019). XIV. Guralp 6TD. Operators’ Guide. Document Number : MAN-T60-0002, Issue J : April, 2017. Guralp Systems Limited. URL : https://www.guralp.com/documents/MAN-T60-0002.pdf (Date of access September 2, 2019). XV. Inshakova, A. S., Barykina, E. S., and Kozlov, V. V. Role of silica gel in adsorption air drying [Rol’ silikagelya v adsorbtsionnoyosushkevozdukha]. AlleyaNauki (Alley of Science). 2017 ; 15. URL : https://www.alley- science.ru/domains_data/files/November2017/ROL%20SILIKAGELYa%20V%20ADSORBCIONNOY%20OSUShKE%20VOZDUHA.pdf(Date of access September 2, 2019). XVI. Ioffe, D. and Pozdnyakov, P. Searching for Hidden Reserves of Modern Microchip Circuits. Part I [Poiskskrytykhrezervovsovremennykhmikroskhem. Chast’ I].Komponenty I tekhnologii (Components and Technologies). 2015 ; 4 : 144-46. XVII. Jiang Xu, Xi Wang, Ningyi Yuan, Jianning Ding, Si Qin, Joselito M. Razal, Xuehang Wang, ShanhaiGe, Gogotsi, Yu. Extending the low temperature operational limit of Li-ion battery to −80 °C. Energy Storage Materials (IF0). Published 2019-04-27. DOI : 10.1016/j.ensm.2019.04.033. XVIII. Kouznetsov, O. L., Lyasch, Y. F., Chirkin, I. A., Rizanov, E. G., LeRoy, S. D., Koligaev, S. O. Long-term monitoring of microseismic emissions : Earth tides, fracture distribution, and fluid content. SEG, APPG Interpretation. 2016 : 4 (2) : T191–T204. XIX. Laverov, N. P., Bogoyavlenskiy, V. I., Bogoyavlenskiy, I. V. Fundamental Aspects of Rational Management of the Petroleum and Gas Resources of the Arctic and the Russian Continental Shelf : Strategy, Prospects, and Problems [Fundamental’nyyeaspektyratsional’nogoosvoyeniyaresursovneftiigazaArktiki I shel’faRossii : strategiya, perspektivyi problem].Arktika : ekologiya I ekonomika [Arctic : Ecology and Economy]. 2016 ; 2 (22) : 4-13. XX. Lee, P. Low Noise Amplifier Selection Guide for Optimal Noise Performance, Analog Devices, Inc., AN-940 Application Note. Analog Devices, Inc. URL : https://www.analog.com/media/en/technical-documentation/application-notes/AN-940.pdf(Date of access September 2, 2019). XXI. Markatis, N., Polychronopoulou, K., Tselentis, Ak. Passive seismic tomography : A passive concept actively evolving. First Break. 2012 ; 30 (7) : 83-90. XXII. Matveev, I. V. and Matveeva, N. V. Portable seismic recorder “SEISAR-5” with very low energy consumption for autonomous work in harsh climatic conditions [Portativnyyseysmicheskiyregistrator «Seysar-5» s ochen’ nizkimenergopotrebleniyemdlyaavtonomnoyraboty v slozhnykhklimatic heskikhusloviyakh]. Nauka I tekhnologicheskierazrabotki (Science and Technological Developments). 2017 ; 96 (3) : 33-40. [Special Issue “Applied Geophysics : New Developments and Results. Part 1. Seismology and Seismic Exploration]. DOI : 10.21455/std2017.3-3. XXIII. Mishra, R. The Temperature Ratings of Electronic Parts.Electronics Cooling magazine. URL : http://www.electronics-cooling.com/2004/02/the-temperature-ratings-of-electronic-parts(Date of access September 2, 2019). XXIV. Moore, Sue E. ; Stabeno, Phyllis J. ; Van Pelt, Thomas I. The Synthesis of Arctic Research (SOAR) project. Deep-Sea Research Part II. 152 : 1-7. DOI : 10.1016/j.dsr2.2018.05.013. XXV. MS-SPORT Viscous Silicone Lubricant with Fluoroplastic. ToR2257-010-45540231-2003. OOO VMPAUTO, URL : https://smazka.ru/attachments/get/469/ms-sport-tds.pdf(Date of access September 2, 2019). XXVI. New Brunswick™ Premium -86 °C Freezers. Operating manual. URL : https://www.eppendorf.com/product-media/doc/en/142770_Operating-Manual/New-Brunswick_Freezers_Operating-manual-86-C-Premium-Freezers.pdf(Date of access September 2, 2019). XXVII. New seismic digitizer/recorder for passive seismic monitoring applications. LandTech Enterprises. URL : http://www.landtechsa.com/Images/Instrument/SRi32L/SRi32L.pdf(Date of access September 2, 2019). XXVIII. Parker, T., Winberry, P., Huerta, A., Bainbridge, G., Devanney, P. Direct Burial Broadband Seismic Instrumentation for Polar Environments. Nanometrics Inc. URL : https://www.nanometrics.ca/sites/default/files/2017-11/direct_burial_bb_seismic_instrumentation_for_polar_environments.pdf. (Date of access September 2, 2019). XXIX. Peterson, J. Observation and Modeling of Seismic Background Noise. Albuquerque, New Mexico : US Department of Interior Geological Survey, 1993. XXX. Razinkov, O.G., Sidorov-Biryukov, D. D., Townsend, B., Parker, T., Bainbridge, G., Greiss, R. Strengths and Applications of Direct Burial Seismic Instruments [Preimushchestva I oblastiprimeneniyaseysmicheskikhpriborovdlyapryamoyustanovki v grunt] in Proc. VI Sci. Tech. Conf. “Problems of Complex Geophysical Monitoring of the Russian Far East”, Petropavlovsk-Kamchatskiy : Geophysical Survey, Russian Academy of Sciences, 2017. URL : http://www.emsd.ru/conf2017lib/pdf/techn/razinkov.pdf (Date of access September 2, 2019). XXXI. Roux, Ph., Wathelet, M., Roueff, Ant. The San Andreas Fault revisited through seismic-noise and surface-wave tomography. Geophysical Research Letters. 2011 ; 38 (13). DOI : 10.1029/2011GL047811. XXXII. Rubber O-ring seals for hydraulic and pneumatic equipment. Specifications [Kol’tsarezinovyyeuplotnitel’nyyekruglogosecheniyadlyagidravlicheskikh I pnevmaticheskikhustroystv. Tekhnicheskiyeusloviya]. GOST 18829-2017 Interstate standard. Moscow : Standartinform, 2017. URL : https://files.stroyinf.ru/Data/645/64562.pdf (Date of access September 2, 2019). XXXIII. Sanina, I., Gabsatarova, I., Chernykh, О.,Riznichenko, О., Volosov, S., Nesterkina, M., Konstantinovskaya, N. The Mikhnevo small aperture array enhances the resolution property of seismological observations on the East European Platform. Journal of Seismology (JOSE). 2011 ; 15 (3) : 545-56. (DOI : 10.1007/sl0950-010-9211-х). XXXIV. SM-3VK Magnetoelectric Seismic Pickup. Specifications. ToR-4314-001-02698826-01. N. Laverov Federal Centre for Integrated Arctic Research, Russian Academy of Sciences. URL : http://fciarctic.ru/index.php?page=ckpg (Date of access September 2, 2019). XXXV. Sobisevich, A. L.,Presnov, D. A.,Agafonov, V. M.,Sobisevich, L. E. Autonomous geohydroacoustic ice buoy of new generation [Vmorazhivayemyyavtonomnyygeogidroakusticheskiy buy novogopokoleniya]. Nauka I tekhnologicheskierazrabotki (Science and Technological Developments). 2018 ; 97 (1) : 25–34. [Special issue “Precise Geophysical Monitoring of Natural Hazards. Part 1. Instruments andTechnologies”]. DOI : 10.21455/ std2018.1-3. XXXVI. Zhukov, Y. V. Issues of resistance and reliability of electronic equipment products to the exposure factors [Voprosystoykosti i nadezhnostiizdeliyradioelektronnoytekhniki k vneshnimvozdeystvuyushchimfaktoram]. Provintsial’nyyenauchnyyezapiski (The journal Provincial scientific proceedings). 2019 ; 1 (9) : 118-124. View | Download COMPARATIVE ANALYSIS OF RESULTS OF TREATMENT OF PATIENTS WITH FOOT PATHOLOGY WHO UNDERWENT WEIL OPEN OSTEOTOMY BY CLASSICAL METHOD AND WITHOUT STEOSYNTHESIS Authors : Yuriy V. Lartsev,Dmitrii A. Rasputin,Sergey D. Zuev-Ratnikov,Pavel V.Ryzhov,Dmitry S. Kudashev,Anton A. Bogdanov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00044 Abstract : The article considers the problem of surgical correction of the second metatarsal bone length. The article analyzes the results of treatment of patients with excess length of the second metatarsal bones that underwent osteotomy with and without osteosynthesis. The results of treatment of patients who underwent metatarsal shortening due to classical Weil-osteotomy with and without osteosynthesis were analyzed. The first group consisted of 34 patients. They underwent classical Weil osteotomy. The second group included 44 patients in whomosteotomy of the second metatarsal bone were not by the screw. When studying the results of the treatment in the immediate postoperative period, weeks 6, 12, slightly better results were observed in patients of the first group, while one year after surgical treatment the results in both groups were comparable. One year after surgical treatment, there were 2.9% (1 patient) of unsatisfactory results in the first group and 4.5% (2 patients) in the second group. Considering the comparability of the results of treatment in remote postoperative period, the choice of concrete method remains with the operating surgeon. Keywords : Flat feet,hallux valgus,corrective osteotomy,metatarsal bones, Refference : I. A novel modification of the Stainsby procedure : surgical technique and clinical outcome [Text] / E. Concannon, R. MacNiocaill, R. Flavin [et al.] // Foot Ankle Surg. – 2014. – Dec., Vol. 20(4). – P. 262–267. II. Accurate determination of relative metatarsal protrusion with a small intermetatarsal angle : a novel simplified method [Text] / L. Osher, M.M. Blazer, S. Buck [et al.] // J. Foot Ankle Surg. – 2014. – Sep.-Oct., Vol. 53(5). – P. 548–556. III. Argerakis, N.G. The radiographic effects of the scarf bunionectomy on rearfoot alignment [Text] / N.G. Argerakis, L.Jr. Weil, L.S. Sr. Weil // Foot Ankle Spec. – 2015. – Apr., Vol. 8(2). – P. 89–94. IV. Bauer, T. Percutaneous forefoot surgery [Text] / T. Bauer // Orthop. Traumatol. Surg. Res. – 2014. – Feb., Vol. 100(1 Suppl.). – P. S191–S204. V. Biomechanical Evaluation of Custom Foot Orthoses for Hallux Valgus Deformity [Text] // J. Foot Ankle Surg. – 2015. – Sep.-Oct., Vol.54(5). – P. 852–855. VI. Chopra, S. Characterization of gait in female patients with moderate to severe hallux valgus deformity [Text] / S. Chopra, K. Moerenhout, X. Crevoisier // Clin. Biomech. (Bristol, Avon). – 2015. – Jul., Vol. 30(6). – P. 629–635. VII. Computer assisted planning and custom-made surgical guide for malunited pronation deformity after first metatarsophalangeal joint arthrodesis in rheumatoid arthritis : a case report [Text] / M. Hirao, S. Ikemoto, H. Tsuboi [et al.] // Comput. Aided Surg. – 2014. – Vol. 19(1-3). – P. 13–19. VIII. Correlation between static radiographic measurements and intersegmental angular measurements during gait using a multisegment foot model [Text] / D.Y. Lee, S.G. Seo, E.J. Kim [et al.] // Foot Ankle Int. – 2015. – Jan., Vol.36(1). – P. 1–10. IX. Correlative study between length of first metatarsal and transfer metatarsalgia after osteotomy of first metatarsal [Text] : [Article in Chinese] / F.Q. Zhang, B.Y. Pei, S.T. Wei [et al.] // Zhonghua Yi XueZaZhi. – 2013. – Nov. 19, Vol. 93(43). – P. 3441–3444. X. Dave, M.H. Forefoot Deformity in Rheumatoid Arthritis : A Comparison of Shod and Unshod Populations [Text] / M.H. Dave, L.W. Mason, K. Hariharan // Foot Ankle Spec. – 2015. – Oct., Vol. 8(5). – P. 378–383. XI. Does arthrodesis of the first metatarsophalangeal joint correct the intermetatarsal M1M2 angle ? Analysis of a continuous series of 208 arthrodeses fixed with plates [Text] / F. Dalat, F. Cottalorda, M.H. Fessy [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6). – P. 709–714. XII. Dynamic plantar pressure distribution after percutaneous hallux valgus correction using the Reverdin-Isham osteotomy [Text] : [Article in Spanish] / G. Rodríguez-Reyes, E. López-Gavito, A.I. Pérez-Sanpablo [et al.] // Rev. Invest. Clin. – 2014. – Jul., Vol. 66, Suppl. 1. – P. S79-S84. XIII. Efficacy of Bilateral Simultaneous Hallux Valgus Correction Compared to Unilateral [Text] / A.V. Boychenko, L.N. Solomin, S.G. Parfeyev [et al.] // Foot Ankle Int. – 2015. – Nov., Vol. 36(11). – P. 1339–1343. XIV. Endolog technique for correction of hallux valgus : a prospective study of 30 patients with 4-year follow-up [Text] / C. Biz, M. Corradin, I. Petretta [et al.] // J. OrthopSurg Res. – 2015. – Jul. 2, № 10. – P. 102. XV. First metatarsal proximal opening wedge osteotomy for correction of hallux valgus deformity : comparison of straight versus oblique osteotomy [Text] / S.H. Han, E.H. Park, J. Jo [et al.] // Yonsei Med. J. – 2015. – May, Vol. 56(3). – P. 744–752. XVI. Long-term outcome of joint-preserving surgery by combination metatarsal osteotomies for shortening for forefoot deformity in patients with rheumatoid arthritis [Text] / H. Niki, T. Hirano, Y. Akiyama [et al.] // Mod. Rheumatol. – 2015. – Sep., Vol. 25(5). – P. 683–638. XVII. Maceira, E. Transfer metatarsalgia post hallux valgus surgery [Text] / E. Maceira, M. Monteagudo // Foot Ankle Clin. – 2014. – Jun., Vol. 19(2). – P.285–307. XVIII. Nielson, D.L. Absorbable fixation in forefoot surgery : a viable alternative to metallic hardware [Text] / D.L. Nielson, N.J. Young, C.M. Zelen // Clin. Podiatr. Med. Surg. – 2013. – Jul., Vol. 30(3). – P. 283–293 XIX. Patient’s satisfaction after outpatient forefoot surgery : Study of 619 cases [Text] / A. Mouton, V. Le Strat, D. Medevielle [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6 Suppl.). – P. S217–S220. XX. Preference of surgical procedure for the forefoot deformity in the rheumatoid arthritis patients–A prospective, randomized, internal controlled study [Text] / M. Tada, T. Koike, T. Okano [et al.] // Mod. Rheumatol. – 2015. – May., Vol. 25(3). – P.362–366. XXI. Redfern, D. Percutaneous Surgery of the Forefoot [Text] / D. Redfern, J. Vernois, B.P. Legré // Clin. Podiatr. Med. Surg. – 2015. – Jul., Vol. 32(3). – P. 291–332. XXII. Singh, D. Bullous pemphigoid after bilateral forefoot surgery [Text] / D. Singh, A. Swann // Foot Ankle Spec. – 2015. – Feb., Vol. 8(1). – P. 68–72. XXIII. Treatment of moderate hallux valgus by percutaneous, extra-articular reverse-L Chevron (PERC) osteotomy [Text] / J. Lucas y Hernandez, P. Golanó, S. Roshan-Zamir [et al.] // Bone Joint J. – 2016. – Mar., Vol. 98-B(3). – P. 365–373. XXIV. Weil, L.Jr. Scarf osteotomy for correction of hallux abducto valgus deformity [Text] / L.Jr. Weil, M. Bowen // Clin. Podiatr. Med. Surg. – 2014. – Apr., Vol.31(2). – P. 233–246. View | Download QUANTITATIVE ULTRASONOGRAPHY OF THE STOMACH AND SMALL INTESTINE IN HEALTHYDOGS Authors : Roman A. Tcygansky,Irina I. Nekrasova,Angelina N. Shulunova,Alexander I.Sidelnikov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00045 Abstract : Purpose.To determine the quantitative echogenicity indicators (and their ratio) of the layers of stomach and small intestine wall in healthy dogs. Methods. A prospective 3-year study of 86 healthy dogs (aged 1-7 yrs) of different breeds and of both sexes. Echo homogeneity and echogenicity of the stomach and intestines wall were determined by the method of Silina, T.L., et al. (2010) in absolute values of average brightness levels of ultrasound image pixels using the 8-bit scale with 256 shades of gray. Results. Quantitative echogenicity indicators of the stomach and the small intestine wall in dogs were determined. Based on the numerical values characterizing echogenicity distribution in each layer of a separate structure of the digestive system, the coefficient of gastric echogenicity is determined as 1:2.4:1.1 (mucosa/submucosa/muscle layers, respectively), the coefficient of duodenum and jejunum echogenicity is determined as 1:3.5:2 and that of ileum is 1:1.8:1. Clinical significance. The echogenicity coefficient of the wall of the digestive system allows an objective assessment of the stomach and intestines wall and can serve as the basis for a quantitative assessment of echogenicity changes for various pathologies of the digestive system Keywords : Ultrasound (US),echogenicity,echogenicity coefficient,digestive system,dogs,stomach,intestines, Refference : I. Agut, A. Ultrasound examination of the small intestine in small animals // Veterinary focus. 2009.Vol. 19. No. 1. P. 20-29. II. Bull. 4.RF patent 2398513, IPC51A61B8 / 00 A61B8 / 14 (2006.01) A method for determining the homoechogeneity and the degree of echogenicity of an ultrasound image / T. Silina, S. S. Golubkov. – No. 2008149311/14 ; declared 12/16/2008 ; publ. 09/10/2010 III. Choi, M., Seo, M., Jung, J., Lee, K., Yoon, J., Chang, D., Park, RD. Evaluation of canine gastric motility with ultrasonography // J. of Veterinary Medical Science. – 2002. Vol. 64. – № 1. – P. 17-21. IV. Delaney, F., O’Brien, R.T., Waller, K.Ultrasound evaluation of small bowel thickness compared to weight in normal dogs // Veterinary Radiology and Ultrasound. 2003 Vol. 44, № 5. Р 577-580. V. Diana, A., Specchi, S., Toaldo, M.B., Chiocchetti, R., Laghi, A., Cipone, M. Contrast-enhanced ultrasonography of the small bowel in healthy cats // Veterinary Radiology and Ultrasound. – 2011. – Vol. 52, № 5. – Р. 555-559. VI. Garcia, D.A.A., Froes, T.R. Errors in abdominal ultrasonography in dogs and cats // J. of Small Animal Practice. – 2012. Vol. 53. – № 9. – P. 514-519. VII. Garcia, D.A.A., Froes, T.R. Importance of fasting in preparing dogs for abdominal ultrasound examination of specific organs // J. of Small Animal Practice. – 2014. Vol. 55. – № 12. – P. 630-634. VIII. Gaschen, L., Granger, L.A., Oubre, O., Shannon, D., Kearney, M., Gaschen, F. The effects of food intake and its fat composition on intestinal echogenicity in healthy dogs // Veterinary Radiology and Ultrasound. 2016. Vol. 57. № 5. P. 546-550 IX. Gaschen, L., Kircher, P., Stussi, A., Allenspach, K., Gaschen, F., Doherr, M., Grone, A. Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies // Veterinary radiology and ultrasound. – 2008. – Vol. 49. – № 1. – Р. 56-64. X. Gil, E.M.U. Garcia, D.A.A. Froes, T.R. In utero development of the fetal intestine : Sonographic evaluation and correlation with gestational age and fetal maturity in dogs // Theriogenology. 2015. Vol. 84, №5. Р. 681-686. XI. Gladwin, N.E. Penninck, D.G., Webster, C.R.L. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs // American Journal of Veterinary Research. 2014. Vol. 75, №4. Р. 349-353. XII. Gory, G., Rault, D.N., Gatel, L, Dally, C., Belli, P., Couturier, L., Cauvin, E. Ultrasonographic characteristics of the abdominal esophagus and cardia in dogs // Veterinary Radiology and Ultrasound. 2014. Vol. 55, № 5. P. 552-560. XIII. Günther, C.S. Lautenschläger, I.E., Scholz, V.B. Assessment of the inter- and intraobserver variability for sonographical measurement of intestinal wall thickness in dogs without gastrointestinal diseases | [Inter-und Intraobserver-Variabilitätbei der sonographischenBestimmung der Darmwanddicke von HundenohnegastrointestinaleErkrankungen] // Tierarztliche Praxis Ausgabe K : Kleintiere – Heimtiere. 2014. Vol. 42 №2. Р. 71-78. XIV. Hanazono, K., Fukumoto, S., Hirayama, K., Takashima, K., Yamane, Y., Natsuhori, M., Kadosawa, T., Uchide, T. Predicting Metastatic Potential of gastrointestinal stromal tumors in dog by ultrasonography // J. of Veterinary Medical Science. – 2012. Vol. 74. – № 11. – P. 1477-1482. XV. Heng, H.G., Lim, Ch.K., Miller, M.A., Broman, M.M.Prevalence and significance of an ultrasonographic colonic muscularishyperechoic band paralleling the serosal layer in dogs // Veterinary Radiology and Ultrasound. 2015. Vol. 56 № 6. P. 666-669. XVI. Ivančić, M., Mai, W. Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs // Veterinary Radiology and Ultrasound. 2008. Vol. 49. № 4. Р. 368-373. XVII. Lamb, C.R., Mantis, P. Ultrasonographic features of intestinal intussusception in 10 dogs // J. of Small Animal Practice. – 2008. Vol. 39. – № 9. – P. 437-441. XVIII. Le Roux, A. B., Granger, L.A., Wakamatsu, N, Kearney, M.T., Gaschen, L.Ex vivo correlation of ultrasonographic small intestinal wall layering with histology in dogs // Veterinary Radiology and Ultrasound.2016. Vol. 57. № 5. P. 534-545. XIX. Nielsen, T. High-frequency ultrasound of Peyer’s patches in the small intestine of young cats / T. Nielsen [et al.] // Journal of Feline Medicine and Surgery. – 2015. – Vol. 18, № 4. – Р. 303-309. XX. PenninckD.G. Gastrointestinal tract. In Nyland T.G., Mattoon J.S. (eds) : Small Animal Diagnostic Ultrasound. Philadelphia : WB Saunders. 2002, 2nd ed. Р. 207-230. XXI. PenninckD.G. Gastrointestinal tract. In : PenninckD.G.,d´Anjou M.A. Atlas of Small Animal Ultrasonography. Blackwell Publishing, Iowa. 2008. Р. 281-318. XXII. Penninck, D.G., Nyland, T.G., Kerr, L.Y., Fisher, P.E. Ultrasonographic evaluation of gastrointestinal diseases in small animals // Veterinary Radiology. 1990. Vol. 31. №3. P. 134-141. XXIII. Penninck, D.G.,Webster, C.R.L.,Keating, J.H. The sonographic appearance of intestinal mucosal fibrosis in cats // Veterinary Radiology and Ultrasound. – 2010. – Vol. 51, № 4. – Р. 458-461. XXIV. Pollard, R.E.,Johnson, E.G., Pesavento, P.A., Baker, T.W., Cannon, A.B., Kass, P.H., Marks, S.L. Effects of corn oil administered orally on conspicuity of ultrasonographic small intestinal lesions in dogs with lymphangiectasia // Veterinary Radiology and Ultrasound. 2013. Vol. 54. № 4. P. 390-397. XXV. Rault, D.N., Besso, J.G., Boulouha, L., Begon, D., Ruel, Y. Significance of a common extended mucosal interface observed in transverse small intestine sonograms // Veterinary Radiology and Ultrasound. 2004. Vol. 45. №2. Р. 177-179. XXVI. Sutherland-Smith, J., Penninck, D.G., Keating, J.H., Webster, C.R.L. Ultrasonographic intestinal hyperechoic mucosal striations in dogs are associated with lacteal dilation // Veterinary Radiology and Ultrasound. – 2007. Vol. 48. – № 1. – P. 51-57. View | Download EVALUATION OF ADAPTIVE POTENTIAL IN MEDICAL STUDENTS IN THE CONTEXT OF SEASONAL DYNAMICS Authors : Larisa A. Merdenova,Elena A. Takoeva,Marina I. Nartikoeva,Victoria A. Belyayeva,Fatima S. Datieva,Larisa R. Datieva, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00046 Abstract : The aim of this work was to assess the functional reserves of the body to quantify individual health ; adaptation, psychophysiological characteristics of the health quality of medical students in different seasons of the year. When studying the temporal organization of physiological functions, the rhythm parameters of physiological functions were determined, followed by processing the results using the Cosinor Analysis program, which reveals rhythms with an unknown period for unequal observations, evaluates 5 parameters of sinusoidal rhythms (mesor, amplitude, acrophase, period, reliability). The essence of desynchronization is the mismatch of circadian rhythms among themselves or destruction of the rhythms architectonics (instability of acrophases or their disappearance). Desynchronization with respect to the rhythmic structure of the body is of a disregulatory nature, most pronounced in pathological desynchronization. High neurotism, increased anxiety reinforces the tendency to internal desynchronization, which increases with stress. During examination stress, students experience a decrease in the stability of the temporary organization of the biosystem and the tension of adaptive mechanisms develops, which affects attention, mental performance and the quality of adaptation to the educational process. Time is shortened and the amplitude of the “initial minute” decreases, personal and situational anxiety develops, and the level of psychophysiological adaptation decreases. The results of the work are priority because they can be used in assessing quality and level of health. Keywords : Desynchronosis,biorhythms,psycho-emotional stress,mesor,acrophase,amplitude,individual minute, Refference : I. Arendt, J., Middleton, B. Human seasonal and circadian studies in Antarctica (Halley, 75_S) – General and Comparative Endocrinology. 2017 : 250-259. (http://dx.doi.org/10.1016/j.ygcen.2017.05.010). II. BalandinYu.P. A brief methodological guide on the use of the agro-industrial complex “Health Sources” / Yu.P. Balandin, V.S. Generalov, V.F. Shishlov. Ryazan, 2007. III. Buslovskaya L.K. Adaptation reactions in students at exam stress/ L.K. Buslovskaya, Yu.P. Ryzhkova. Scientific bulletin of Belgorod State University. Series : Natural Sciences. 2011;17(21):46-52. IV. Chutko L. S. Sindromjemocionalnogovygoranija – Klinicheskie I psihologicheskieaspekty./ L.S Chutko. Moscow : MEDpress-inform, 2013. V. Eroshina K., Paul Wilkinson, Martin Mackey. The role of environmental and social factors in the occurrence of diseases of the respiratory tract in children of primary school age in Moscow. Medicine. 2013:57-71. VI. Fagrell B. “Microcirculation of the Skin”. The physiology and pharmacology of the microcirculation. 2013:423. VII. Gurova O.A. Change in blood microcirculation in students throughout the day. New research. 2013 ; 2 (35):66-71. VIII. Khetagurova L.G. – Stress/Ed. L.G. Khetagurov. Vladikavkaz : Project-Press Publishing House, 2010. IX. Khetagurova L.G., Urumova L.T. et al. Stress (chronomedical aspects). International Journal of Experimental Education 2010 ; 12 : 30-31. X. Khetagurova L.G., Salbiev K.D., Belyaev S.D., Datieva F.S., Kataeva M.R., Tagaeva I.R. Chronopathology (experimental and clinical aspects/ Ed. L.G. Khetagurov, K.D. Salbiev, S.D.Belyaev, F.S. Datiev, M.R. Kataev, I.R. Tagaev. Moscow : Science, 2004. XI. KlassinaS.Ya. Self-regulatory reactions in the microvasculature of the nail bed of fingers in person with psycho-emotional stress. Bulletin of new medical technologies, 2013 ; 2 (XX):408-412. XII. Kovtun O.P., Anufrieva E.V., Polushina L.G. Gender-age characteristics of the component composition of the body in overweight and obese schoolchildren. Medical Science and Education of the Urals. 2019 ; 3:139-145. XIII. Kuchieva M.B., Chaplygina E.V., Vartanova O.T., Aksenova O.A., Evtushenko A.V., Nor-Arevyan K.A., Elizarova E.S., Efremova E.N. A comparative analysis of the constitutional features of various generations of healthy young men and women in the Rostov Region. Modern problems of science and education. 2017 ; 5:50-59. XIV. Mathias Adamsson1, ThorbjörnLaike, Takeshi Morita – Annual variation in daily light expo-sure and circadian change of melatonin and cortisol consent rations at a northern latitude with large seasonal differences in photoperiod length – Journal of Physiological Anthropology. 2017 ; 36 : 6 – 15. XV. Merdenova L.A., Tagaeva I.R., Takoeva E.A. Features of the study of biological rhythms in children. The results of fundamental and applied research in the field of natural and technical sciences. Materials of the International Scientific and Practical Conference. Belgorod, 2017, pp. 119-123. XVI. Ogarysheva N.V. The dynamics of mental performance as a criterion for adapting to the teaching load. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. 2014;16:5 (1) : S.636-638. XVII. Pekmezovi T. Gene-environment interaction : A genetic-epidemiological approach. Journal of Medical Biochemistry. 2010;29:131-134. XVIII. Rapoport S.I., Chibisov S.M. Chronobiology and chronomedicine : history and prospects/Ed. S.M. Chibisov, S.I. Rapoport ,, M.L. Blagonravova. Chronobiology and Chronomedicine : Peoples’ Friendship University of Russia (RUDN) Press. Moscow, 2018. XIX. Roustit M., Cracowski J.L. “Non-invasive assessment of skin microvascular function in humans : an insight into methods” – Microcirculation 2012 ; 19 (1) : 47-64. XX. Rud V.O., FisunYu.O. – References of the circadian desinchronosis in students. Ukrainian Bulletin of Psychoneurology. 2010 ; 18(2) (63) : 74-77. XXI. Takoeva Z. A., Medoeva N. O., Berezova D. T., Merdenova L. A. et al. Long-term analysis of the results of chronomonitoring of the health of the population of North Ossetia ; Vladikavkaz Medical and Biological Bulletin. 2011 ; 12(12,19) : 32-38. XXII. Urumova L.T., Tagaeva I.R., Takoeva E.A., Datieva L.R. – The study of some health indicators of medical students in different periods of the year. Health and education in the XXI century. 2016 ; 18(4) : 94-97. XXIII. Westman J. – Complex diseases. In : Medical genetics for the modern clinician. USA : Lippincott Williams & ; Wilkins, 2006. XXIV. Yadrischenskaya T.V. Circadian biorhythms of students and their importance in educational activities. Problems of higher education. Pacific State University Press. 2016 ; 2:176-178. View | Download TRIADIC COMPARATIVE ANALYSIS Authors : Stanislav A.Kudzh,Victor Ya. Tsvetkov, DOI : https://doi.org/10.26782/jmcms.spl.10/2020.06.00047 Abstract : The present study of comparison methods based on the triadic model introduces the following concepts : the relation of comparability and the relation of comparison, and object comparison and attributive comparison. The difference between active and passive qualitative comparison is shown, two triadic models of passive and active comparison and models for comparing two and three objects are described. Triadic comparison models are proposed as an alternative to dyadic comparison models. Comparison allows finding the common and the different ; this approach is proposed for the analysis of the nomothetic and ideographic method of obtaining knowledge. The nomothetic method identifies and evaluates the general, while the ideographic method searches for unique in parameters and in combinations of parameters. Triadic comparison is used in systems and methods of argumentation, as well as in the analysis of consistency/inconsistency. Keywords : Comparative analysis,dyad,triad,triadic model,comparability relation,object comparison,attributive comparison,nomothetic method,ideographic method, Refference : I. AltafS., Aslam.M.Paired comparison analysis of the van Baarenmodel using Bayesian approach with noninformativeprior.Pakistan Journal of Statistics and Operation Research 8(2) (2012) 259{270. II. AmooreJ. E., VenstromD Correlations between stereochemical assessments and organoleptic analysis of odorous compounds. Olfaction and Taste (2016) 3{17. III. BarnesJ., KlingerR. Embedding projection for targeted cross-lingual sentiment : model comparisons and a real-world study. Journal of Artificial Intelligence Research 66 (2019) 691{742. doi.org/10.1613/jair.1.11561 IV. Castro-SchiloL., FerrerE.Comparison of nomothetic versus idiographic-oriented methods for making predictions about distal outcomes from time series data. Multivariate Behavioral Research 48(2) (2013) 175{207. V. De BonaG.et al. Classifying inconsistency measures using graphs. Journal of Artificial Intelligence Research 66 (2019) 937{987. VI. FideliR. La comparazione. Milano : Angeli, 1998. VII. GordonT. F., PrakkenH., WaltonD. The Carneades model of argument and burden of proof. Artificial Intelligence 10(15) (2007) 875{896. VIII. GrenzS.J. The social god and the relational self : A Triad theology of the imago Dei. Westminster : John Knox Press, 2001. IX. HermansH.J. M.On the integration of nomothetic and idiographic research methods in the study of personal meaning.Journal of Personality 56(4) (1988) 785{812. X. JamiesonK. G., NowakR. Active ranking using pairwise comparisons.Advances in Neural Information Processing Systems (2011) 2240{2248. XI. JongsmaC.Poythress’s triad logic : a review essay. Pro Rege 42(4) (2014) 6{15. XII. KärkkäinenV.M. Trinity and Religious Pluralism : The Doctrine of the Trinity in Christian Theology of Religions. London : Routledge, 2017. XIII. KudzhS. A., TsvetkovV.Ya. Triadic systems. Russian Technology Magazine 7(6) (2019) 74{882. XIV. NelsonK.E.Some observations from the perspective of the rare event cognitive comparison theory of language acquisition.Children’s Language 6 (1987) 289{331. XV. NiskanenA., WallnerJ., JärvisaloM.Synthesizing argumentation frameworks from examples. Journal of Artificial Intelligence Research 66 (2019) 503{554. XVI. PührerJ.Realizability of three-valued semantics for abstract dialectical frameworks.Artificial Intelligence 278 (2020) 103{198. XVII. SwansonG.Frameworks for comparative research : structural anthropology and the theory of action. In : Vallier, Ivan (Ed.). Comparative methods in sociology : essays on trends and applications.Berkeley : University of California Press, 1971 141{202. XVIII. TsvetkovV.Ya.Worldview model as the result of education.World Applied Sciences Journal 31(2) (2014) 211{215. XIX. TsvetkovV. Ya. Logical analysis and variable scales. Slavic Forum 4(22) (2018) 103{109. XX. Wang S. et al. Transit traffic analysis zone delineating method based on Thiessen polygon. Sustainability 6(4) (2014) 1821{1832. View | Download DEVELOPING TECHNOLOGY OF CREATING WEAR-RESISTANT CERAMIC COATING FOR ICE CYLINDER ». JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES spl10, n^o 1 (28 juin 2020). http://dx.doi.org/10.26782/jmcms.spl.10/2020.06.00048.

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