Articles de revues : « 547/.05 »

1

Chaix, Benjamin, Jean-Emmanuel Bibault, Rolland Romain, Arthur Guillemassé, Mikaël Neeral, Guillaume Delamon, Julien Moussalli et Benoît Brouard. « Assessing the performances of a chatbot to collect real-life data of patients suffering from primary headache disorders ». DIGITAL HEALTH 8 (janvier 2022) : 205520762210977. http://dx.doi.org/10.1177/20552076221097783.

Texte intégral

Résumé :

Background There are many scales for screening the impact of a disease. These scales are generally used to diagnose or assess the type and severity of a disease and are carried out by doctors. The chatbot helps patients suffering from primary headache disorders through personalized text messages. It could be used to collect patient-reported outcomes. Objective The aims of this study were (1) to study whether the collection and analysis of remote scores, without prior medical intervention, are possible by a chatbot, (2) to perform suggested diagnosis and define the type of headaches, and (3) to assess the patient satisfaction and engagement with the chatbot. Method Voluntary users of the chatbot were recruited online. They had to be over 18 and have a personal history of headaches. A questionnaire was presented (1) by text messages to the participants to evaluate migraines (2) based on the criteria of the International Headache Society. Then, the Likert scale (3) was used to assess overall satisfaction with the use of the chatbot. Results We included 610 participants with primary headache disorders. A total of 89.94% (572/610) participants had fully completed the questionnaire (eight items), 4.72% (30/610) had partially completed it, and 5.41% (33) had refused to complete it. Statistical analysis was performed on 86.01% (547/610) of participants. Auto diagnostic showed that 14.26% (78/547) participants had a tension headache, and 85.74% (469/547) had a probable migraine. In this population, 15.78% (74/469) suffered from migraine without probable aura, and 84.22% (395/469) had migraine without aura. The patient’s age had a significant incidence regarding the auto diagnosis ( P = .008<.05). The evaluation of overall satisfaction shows that a total of 93.9% (599/610) of users were satisfied or very satisfied regarding the timeliness of responses the chatbot provides. Conclusion The study confirmed that it was possible to obtain such a collection remotely, and quickly (average time of 3.24 min) with a high success rate (89.67% (547/610) participants who had fully completed the IHS questionnaire). Users were strongly engaged through chatbot: out of the total number of participants, we observed a very low number of uncompleted questionnaires (6.23% (38/610)). Conversational agents can be used to remotely collect data on the nature of the symptoms of patients suffering from primary headache disorders. These results are promising regarding patient engagement and trust in the chatbot.

Styles APA, Harvard, Vancouver, ISO, etc.

2

J, RAGHAVENDRA K., et A. SURESH. « An analysis of economic benefits from adoption of drought tolerant soybean (Glycine max) in Madhya Pradesh ». Indian Journal of Agricultural Sciences 90, n^o 10 (4 décembre 2020) : 1888–93. http://dx.doi.org/10.56093/ijas.v90i10.107890.

Texte intégral

Résumé :

The research conducted to estimate the potential economic benefit from adoption of drought tolerant soybean (Glycine max (L.) Merr.) variety NRC-7 in Indore district of Madhya Pradesh, where majority of area is under rainfed system. In this study, the potential economic benefit in terms of economic surplus and risk reduction was estimated for NRC-7 and alternative varieties, JS-93-05 and JS 95-60. NRC-7 requires less cost of cultivation compared to other two varieties, and withstands stress condition. In normal condition, the economic surplus for NRC-7 was ₹ 686 million per year, and that of, JS-93-05 and JS 95-60 is about ₹ 3161 million, ₹ 6291 million, respectively. For NRC-7, the risk reduction benefit was to the level of ₹ 547 million, which accounted for about 83.8% of total benefits for that variety. On per ha basis, NRC 7 performs well over the other two varieties in reducing the fluctuation in income of farmers. So there is a need to develop and increase the awareness of abiotic stress tolerant varieties to cope up with the income fluctuation due to weather risks.

Styles APA, Harvard, Vancouver, ISO, etc.

3

Debora Valentina, Tience, Firmanto Adi Nurcahyo et Dewi Puri Astiti. « Self-efficacy and well-being of youth during the COVID-19 pandemic in Indonesia ». Salud mental 46, n^o 4 (20 juillet 2023) : 185–92. http://dx.doi.org/10.17711/sm.0185-3325.2023.023.

Texte intégral

Résumé :

Introduction. The impact of the COVID-19 pandemic on the well-being of young people has attracted the concerned of many parties. Self-efficacy, an individual’s belief to cope with various situations, is believed to have a relationship with individual’s psychological well-being. Objective. To explore the relationship between self-efficacy and well-being of young people in Indonesia during the COVID-19 pandemic. Method. A cross-sectional design with a convenience sample of high schools and universities students in Indonesia. The number of participants were 365 young people aged 15-23 years (M = 18.57; SD = 1.95). They were asked to complete the Self-efficacy Scale and the Flourishing Scale in the form of an online survey. Results. There is a positive correlation between self-efficacy and well-being (r = .547, p () .01) with the contribution percentage of 33.5%. The two-way ANOVA resulted there was an effect of education level on wellbeing (F = 12.956, p () .05), while there was no gender effect on wellbeing (F = .006, p #cer# .05). Discussion and conclusion. The findings of this study highlighting the importance of developing self-efficacy in young people in order to promote well-being despite facing a challenging situation.

Styles APA, Harvard, Vancouver, ISO, etc.

4

Киселев, В. А., et З. В. Киселева. « Анализ стилей спортивного плавания для коррекции осанки ». Тенденции развития науки и образования 97, n^o 10 (2023) : 60–63. http://dx.doi.org/10.18411/trnio-05-2023-547.

Texte intégral

Résumé :

В статье рассматривается современная проблема, связанная с ухудшением осанки детей, которым предписано для коррекции осанки заниматься плаванием. Рассматриваются спортивные стили плавания с позиции корригирующих средств.

Styles APA, Harvard, Vancouver, ISO, etc.

5

Liu, Liangchen, Di Yang, Shuanglin Zhao, Shiliang Ding et Yuntao Ni. « Clinical Observation of Wound Fluid Extravasation after Shoulder Arthroscopy ». Journal of Contemporary Medical Practice 6, n^o 6 (30 juin 2024) : 23–27. http://dx.doi.org/10.53469/jcmp.2024.06(06).05.

Texte intégral

Résumé :

Fluid leakage to the outside of the wound after shoulder arthroscopy can present a risk of complications such as wound infection and delayed wound healing. Most relevant studies dealt with fluid leakage to the internal environment and did not focus on fluid leakage outside the body and its effect on the wound. We, therefore, focused on and investigated the significance of wound fluid leakage to the body surface after shoulder arthroscopy. Methods: Observational and analyzed patient data from 15 cases of shoulder arthroscopy were used to calculate the amount of fluid exudation by recording the operation time, the amount of intraoperative fluid perfusion, the surgical incisions, and weighing the surgical dressings on the first day of the postoperative period. The statistical method of Pearson's correlation coefficient was used to evaluate the correlation between the patients' postoperative fluid exudate volume and the operation time, intraoperative fluid infusion volume, and surgical incision. Results: All patients had no incision infections or other postoperative complications. The duration of surgery and the amount of postoperative wound exudate were correlated in 15 patients (R=.547, p<.05), the amount of perfusion and the amount of postoperative wound exudate were statistically significant (R=.569, p<.05), and the incisions and the amount of postoperative wound exudate were statistically significant (R=.702, p<.05). Conclusion: There is a correlation between postoperative fluid exudation after shoulder arthroscopy and operative time, intraoperative perfusion, and surgical incisions. When the operator performs shoulder arthroscopy, he or she should try to shorten the operative time and reduce intraoperative fluid perfusion and surgical incisions.

Styles APA, Harvard, Vancouver, ISO, etc.

6

Seyyar, Gulce Kallem, Bahar Aras et Ozgen Aras. « Trunk Control in Children With Ataxic Cerebral Palsy ». Perceptual and Motor Skills 126, n^o 5 (24 juin 2019) : 815–27. http://dx.doi.org/10.1177/0031512519858275.

Texte intégral

Résumé :

This study aimed to investigate the clinical characteristics of trunk control in children with ataxic cerebral palsy (CP). We included 15 children with ataxic CP with a mean age of 9.46 years ( SD = 1.08 years, 5–17 years) and 15 healthy children with a mean age of 9.06 years ( SD = 0.84 years, 5–13 years). While the small sample size and large age range used here were not ideal for generalizability, they were made necessary by the rarity of this clinical sample. We used the Gross Motor Function Classification System Expanded and Revised (GMFCS-E&R) to classify the children’s functional levels, and we tested trunk control with the Trunk Control Measurement Scale (TCMS). We then used the Gross Motor Function Measurement-88 (GMFM-88) to assess their gross motor functions. We compared the total and subscale scores of the TCMS in healthy children and children with ataxic CP by using the Mann–Whitney U Test. We also analyzed differences between TCMS scores according to the children’s GMFCS levels with the Mann–Whitney U Test and also compared TCMS scores with the GMFM-88 by means of Spearman correlation analysis. Spearman correlation analysis was used to compare the scores of the TCMS with the GMFM-88. Our results showed that healthy children showed significantly higher scores than children with ataxic CP in total and subscale scores of TCMS ( p < .05).There was no significant difference between the TCMS scores in children of different GMFCS levels, but the GMFM-88B subscale was signiﬁcantly correlated with the static sitting balance ( rho = .568, p < .05) and dynamic sitting balance ( rho = .547, p < .05) TCMS subscales and with the TCMS total score ( rho = .590, p < .05). We concluded that trunk control, especially its dynamic aspects, was impaired in children with ataxic CP.

Styles APA, Harvard, Vancouver, ISO, etc.

7

Hatendi, P. R., F. M. Mulenga, S. Sibanda et P. Ndlovu. « The effect of diet and frequency of watering on the performance of growing cattle given food at maintenance ». Animal Science 63, n^o 1 (août 1996) : 33–38. http://dx.doi.org/10.1017/s1357729800028253.

Texte intégral

Résumé :

AbstractAn 18-week experiment investigated the effects of type of diet and frequency of watering on the performance of growing cattle given food at maintenance (metabolizable energy (ME) allowance (MJ) = 8·3 + 0·091 M where M = live weight of the animal). Three diets with 20: 80 (low, L), 50:50 (medium, M) and 80: 20 (high, H) roughage to concentrate ratios (10·2, 7·8 and 5·4 MJME per kg dry matter) were used in combination with free access to water for 2·5 h once daily or once every 3rd day. A completely randomized-block design with a 3 (diets) × 2 (watering frequencies) factorial arrangement of treatments was used. Five animals were allocated per treatment (average weight 245 (s.d. 21·6) kg).Dry-matter intake increased as the roughage content of the diet increased (P < 0·05) but was not affected by the watering regime (P > 0·05). Total water intake was found to be positively correlated with dry-matter intake and increased with dietary roughage level. Animals watered daily drank more (P < 0·05) water (12·6 v. 10·0 kg/day) than those watered every 3rd day. The apparent digestibility of the diets decreased as the amount of roughage increased (diet L 734g/kg, M471 g/kg and H 433 g/kg). Similar apparent digestibilities were observed under the two watering frequencies (546 g/kg and 547 g/kg).Type of diet significantly (P < 0·05) affected the final weights of the steers. Animals given diet H were proportionately 0·07 heavier than those offered diet L corresponding to total weight changes of −0·8 and +18·4 kg respectively. Carcass weight, backfat thickness and eye muscle area were not affected by the treatments. The chemical composition of the 9 to 11th rib joint was only affected by diet H which gave less fat (P < 0·05). Water, fat, protein and ash content averaged 607,118,190 and 84 g/kg respectively.

Styles APA, Harvard, Vancouver, ISO, etc.

8

Hecking, Julia, Pasha A. Davoudian et Samuel T. Wilkinson. « Emerging Therapeutics Based on the Amino Acid Neurotransmitter System : An Update on the Pharmaceutical Pipeline for Mood Disorders ». Chronic Stress 5 (janvier 2021) : 247054702110204. http://dx.doi.org/10.1177/24705470211020446.

Texte intégral

Résumé :

Mood disorders represent a pressing public health issue and significant source of disability throughout the world. The classical monoamine hypothesis, while useful in developing improved understanding and clinical treatments, has not fully captured the complex nature underlying mood disorders. Despite these shortcomings, the monoamine hypothesis continues to dominate the conceptual framework when approaching mood disorders. However, recent advances in basic and clinical research have led to a greater appreciation for the role that amino acid neurotransmitters play in the pathophysiology of mood disorders and as potential targets for novel therapies. In this article we review progress of compounds that focus on these systems. We cover both glutamate-targeting drugs such as: esketamine, AVP-786, REL-1017, AXS-05, rapastinel (GLYX-13), AV-101, NRX-101; as well as GABA-targeting drugs such as: brexanolone (SAGE-547), ganaxolone, zuranolone (SAGE-217), and PRAX-114. We focus the review on phase-II and phase-III clinical trials and evaluate the extant data and progress of these compounds.

Styles APA, Harvard, Vancouver, ISO, etc.

9

Kennedy, Katherine, John R. Bowblis et Katherine M. Abbott. « ONE-TWO PUNCH OF HIGH WAGES AND EMPOWERING PRACTICES FOR MAINTAINING CARE NETWORKS IN NURSING HOMES ». Innovation in Aging 3, Supplement_1 (novembre 2019) : S559—S560. http://dx.doi.org/10.1093/geroni/igz038.2068.

Texte intégral

Résumé :

Abstract Stabilizing certified nursing assistant (CNA) employment is necessary for maintaining care networks and providing high quality of care for nursing home (NH) residents. This study’s objective was to examine the relationship of high wages and empowerment practices on CNA retention. We used the 2015 Ohio Biennial Survey to construct a facility-level dataset of 547 NHs and estimated multivariable linear regressions. NHs that provided both high wages and high empowerment were associated with a 12.95 percentage-point improvement in the CNA retention rate (SE = 4.53, t-value = 2.86, p = 0.0045). High wages and a high empowerment score did not have significant effects individually (p > .05). Retention rates were similar between NHs that lacked high wages and scored low on the empowerment scale, and NHs that provided one at a high level but not the other. Implications for better retaining CNAs require multiple empowerment practices combined with high hourly wages.

Styles APA, Harvard, Vancouver, ISO, etc.

10

Coogan, John J. « Pathogen Control in Complex Fluids with Water-coupled Excimer Lamps at 282 and 308 nm ». Photochemistry and Photobiology 81, n^o 6 (2005) : 1511. http://dx.doi.org/10.1562/2005-05-27-ra-547.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

11

Morgan, Juliette, Martin I. Meltzer, Brian D. Plikaytis, Andre N. Sofair, Sharon Huie-White, Steven Wilcox, Lee H. Harrison, Eric C. Seaberg, Rana A. Hajjeh et Steven M. Teutsch. « Excess Mortality, Hospital Stay, and Cost Due to Candidemia : A Case-Control Study Using Data From Population-Based Candidemia Surveillance ». Infection Control & ; Hospital Epidemiology 26, n^o 6 (juin 2005) : 540–47. http://dx.doi.org/10.1086/502581.

Texte intégral

Résumé :

AbstractObjective:To determine the mortality, hospital stay, and total hospital charges and cost of hospitalization attributable to candidemia by comparing patients with candidemia with control-patients who have otherwise similar illnesses. Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices.Design:Our case-control study included case-patients with candidemia and their cost-related data, ascertained from laboratory-based candidemia surveillance conducted among all residents of Connecticut and Baltimore and Baltimore County, Maryland, during 1998 to 2000. Control-patients were matched on age, hospital type, admission year, discharge diagnoses, and duration of hospitalization prior to candidemia onset.Results:We identified 214 and 529 sets of matched case-patients and control-patients from the two locations, respectively. Mortality attributable to candidemia ranged between 19% and 24%. On multivariable analysis, candidemia was associated with mortality (OR, 5.3 for Connecticut and 8.5 for Baltimore and Baltimore County;P< .05), whereas receiving adequate treatment was protective (OR, 0.5 and 0.4 for the two locations, respectively;P< .05). Candidemia itself did not increase the total hospital charges and cost of hospitalization; when treatment status was accounted for, having received adequate treatment for candidemia significantly increased the total hospital charges and cost of hospitalization ($6,000 to $29,000 and $3,000 to $22,000, respectively) and the length of stay (3 to 13 days).Conclusion:Our findings underscore the burden of candidemia, particularly regarding the risk of death, length of hospitalization, and cost associated with treatment (Infect Control Hosp Epidemiol2005;26:540-547).

Styles APA, Harvard, Vancouver, ISO, etc.

12

Goto, Heita, et James A. King. « High-Intensity Demands of 6-a-Side Small-Sided Games and 11-a-Side Matches in Youth Soccer Players ». Pediatric Exercise Science 31, n^o 1 (1 février 2019) : 85–90. http://dx.doi.org/10.1123/pes.2018-0122.

Texte intégral

Résumé :

Purpose: The purposes of the present study were to examine high-intensity running distance during 6-a-side small-sided games (SSGs) and 11-a-side matches (11M) in youth soccer players using speed and metabolic power approaches and the magnitude of difference between the high-intensity running distance calculated with the 2 approaches. Method: A total of 11 outfield players (age = 16.3 [0.6] y) performed SSGs with 3 pitch sizes (small SSG [SSGS], medium SSG, and large SSG [SSGL]) and 11M. A Global Positioning System (15 Hz) was employed to calculate total distance covered, distance covered at a speed ≥4.3 m·s−1 (TS), and metabolic power of ≥20 W·kg−1 (TP). Results: The total distance covered increased from SSGS through to SSGL (P < .001) and was greater during 11M and SSGL compared with other SSGs (P < .01). TS and TP increased from SSGS (TS vs TP = 98 [55] vs 547 [181] m) through to SSGL (538 [167] vs 1050 [234] m; P < .001). TS and TP during 11M (370 [122] vs 869 [233] m) was greater than SSGS (P < .001 for both) and less than SSGL (P < .05 for both). The magnitude of difference between TS and TP (as a percentage) was lower with an increase in pitch size during SSGs and was greater in SSGS (615% [404%]; P < .001), medium SSG (195% [76%]; P < .05), and smaller in SSGL (102% [33%]; P < .01) compared with 11M (145% [53%]). Conclusion: SSGs can replicate the high-intensity demands of 11M and the speed approach underestimates the high-intensity demands of SSGs and 11M compared with the metabolic power approach.

Styles APA, Harvard, Vancouver, ISO, etc.

13

Chen, Qiong, Xin-lu Cheng et Xiang-dong Yang. « Influence of New Interaction Potential on MD Simulation of MgSiO3 Perovskite Thermodynamic Properties ». Chinese Journal of Chemical Physics 20, n^o 5 (octobre 2007) : 547–51. http://dx.doi.org/10.1088/1674-0068/20/05/547-551.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

14

Zhang, Ai-jie, et Guo-zhong He. « Quantum Mechanics Rate Constant for the N+ND Reaction ». Chinese Journal of Chemical Physics 24, n^o 5 (octobre 2011) : 547–50. http://dx.doi.org/10.1088/1674-0068/24/05/547-550.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

15

Tao, Qian, Wei Chen, Yao Yao, Ammar Bin Yousaf et Yan-xia Chen. « Study on Methanol Oxidation at Pt and PtRu Electrodes by Combiningin situInfrared Spectroscopy and Differential Electrochemical Mass Spectrometry ». Chinese Journal of Chemical Physics 27, n^o 5 (27 octobre 2014) : 541–47. http://dx.doi.org/10.1063/1674-0068/27/05/541-547.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

16

Ueda, Sho, Daisuke Oryoji, Ken Yamamoto, Jaeduk Yoshimura Noh, Ken Okamura, Mitsuhiko Noda, Koichi Kashiwase et al. « Identification of Independent Susceptible and Protective HLA Alleles in Japanese Autoimmune Thyroid Disease and Their Epistasis ». Journal of Clinical Endocrinology & ; Metabolism 99, n^o 2 (1 février 2014) : E379—E383. http://dx.doi.org/10.1210/jc.2013-2841.

Texte intégral

Résumé :

Background: Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto thyroiditis (HT), which partially share immunological features. Determining the genetic basis that distinguishes GD and HT is a key to understanding the differences between these 2 related diseases. Aim: The aims of this study were to identify HLA antigens that can explain the immunopathological difference between GD and HT and to elucidate epistatic interactions between protective and susceptible HLA alleles, which can delineate the distinct function of HLA in AITD etiology. Design: We genotyped 991 patients with AITD (547 patients with GD and 444 patients with HT) and 481 control subjects at the HLA-A, HLA-C, HLA-B, DRB1, DQB1, and DPB1 loci. A direct comparison of HLA antigen frequencies between GD and HT was performed. We further analyzed an epistatic interaction between the susceptible and protective HLA alleles in the development of GD and HT. Results: We identified 4 and 2 susceptible HLA molecules primarily associated with GD and HT, respectively, HLA-B*35:01, HLA-B*46:01, HLA-DRB1*14:03, and HLA-DPB1*05:01 for GD and HLA-A*02:07 and HLA-DRB4 for HT. In a direct comparison between GD and HT, we identified GD-specific susceptible class II molecules, HLA-DP5 (HLA-DPB1*05:01; Pc = 1.0 × 10−9) and HLA-DR14 (HLA-DRB*14:03; Pc = .0018). In contrast, HLA components on 3 common haplotypes in Japanese showed significant protective effects against the development of GD and HT (HLA-A*24:02-C*12:02-B*52:01-DRB1*15:02-DQB1*06:01-DPB1*09:01 and HLA-A*24:02-C*07:02-B*07:02-DRB1*01:01-DQB1*05:01-DPB1*04:02 haplotypes for GD and HLA-A*33:03-C*14:03-B*44:03-DRB1*13:02-DQB1*06:04-DPB1*04:01 haplotype for GD and HT). Interestingly, the representative protective HLA, HLA-DR13 (HLA-DRB1*13:02), was epistatic to susceptible HLA-DP5 in controlling the development of GD. Conclusion: We show that HLA exerts a dual function, susceptibility and resistance, in controlling the development of GD and HT. We also show that the protective HLA allele is partially epistatic to the susceptible HLA allele in GD.

Styles APA, Harvard, Vancouver, ISO, etc.

17

Boegemann, Martin, Michael Woike, Johanna Gillhaus et Andres Jan Schrader. « Comparison of different prognostic scores versus physician’s subjective prognosis in patients with advanced/metastatic renal cell carcinoma treated with temsirolimus in regular clinical setting : An analysis of the STAR-TOR registry. » Journal of Clinical Oncology 35, n^o 6_suppl (20 février 2017) : 441. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.441.

Texte intégral

Résumé :

441 Background: In treatment of metastatic renal cell carcinoma (mRCC) patients several prognostic scores are used: the MSKCC-, IMDC-, and for pts treated with Temsirolimus (TEMS) the Hudes-score. We assessed prognostic value of these scores in TEMS treated cohort and compared the results with physician’s prognosis. Methods: A German multicenter registry for pts with mRCC (NCT00700258) was established to evaluate the safety and efficacy of TEMS in clinical routine. We retrospectively analyzed the data to compare established prognostic scores with risk assessment by the treating physician and match them with survival outcomes. Results: From 02/2008-05/2015, 547 mRCC pts were treated with TEMS. Risk was calculated for 305 (MSKCC), 248 (IMDC), and 187 (Hudes) pts. Physician’s prognosis was documented for 530 pts. Multivariate survival analyses are shown in table below. Abbreviations: g (good), i (intermediate), p (poor), n-p (non-poor). Conclusions: Risk assessment by treating physician is as meaningful as objective prognostic scores. In this data set, IMDC and Hudes performed worse than the MSKCC score. Physician’s risk assessment independently discriminates better between good and intermediate risk. The MSKCC score performs better for discrimination between an intermediate and a poor prognosis. Thus, the physician seems to be able to identify a subset of patients with a good prognosis while the MSKCC score can identify pts which are falsely placed in poor risk group by the physician. [Table: see text]

Styles APA, Harvard, Vancouver, ISO, etc.

18

Hauta-alus, Helena H., Liisa Korkalo, Riitta Freese, Carina Ismael et Marja Mutanen. « Urban and rural dietary patterns are associated with anthropometric and biochemical indicators of nutritional status of adolescent Mozambican girls ». Public Health Nutrition 21, n^o 6 (22 décembre 2017) : 1057–64. http://dx.doi.org/10.1017/s1368980017003676.

Texte intégral

Résumé :

AbstractObjectiveThe objective of the present study was to explore whether dietary patterns (DP) are associated with nutritional status indicators among adolescent Mozambican girls.Design/Setting/SubjectsIn this population-based cross-sectional study we used the FFQ data of 547 girls aged 14–19 years from Central Mozambique to derive dietary patterns by means of principal component analysis. We used two-level linear regression models to examine the associations between the DP and anthropometric and biochemical indicators of nutritional status.ResultsWe identified three DP: ‘Urban bread and fats’, ‘Rural meat and vegetables’ and ‘Rural cassava and coconut’. The ‘Urban bread and fats’ DP was positively associated with BMI-for-age Z-score (BMIZ), mid-upper arm circumference (MUAC), triceps skinfold (P for all<0·001) and blood Hb (P=0·025). A negative association was observed between the ‘Urban bread and fats’ DP and serum folate (P<0·001). The ‘Rural meat and vegetables’ DP and the ‘Rural cassava and coconut’ DP were associated negatively with BMIZ, MUAC and triceps skinfold (P for all<0·05), but the ‘Rural meat and vegetables’ DP was associated positively with serum ferritin (P=0·007).ConclusionsUrban and rural DP were associated with nutritional status indicators. In a low-resource setting, urban diets may promote body fat storage and blood Hb concentrations but compromise serum folate concentration. It is important to continue valuing the traditional, rural foods that are high in folate.

Styles APA, Harvard, Vancouver, ISO, etc.

19

Cakra, Cakra. « PENGARUH BUDAYA KERJA TERHADAP EFEKTIVITAS PELAYANAN PUBLIK KANTOR DESA TIMORENG PANUA KECAMATAN PANCA RIJANG KABUPATEN SIDENRENG RAPPANG ». PRAJA : Jurnal Ilmiah Pemerintahan 8, n^o 2 (22 juin 2020) : 148–54. http://dx.doi.org/10.51817/prj.v8i2.246.

Texte intégral

Résumé :

Abstract The purpose of this research is to determinate the effect of work culture on the effectiness of public service in the office village of Timoreng Panua, Panca Rijang district, Sidenreng Rappang Regency. The populations of this research is the whole of Family card as much as 547 of 2 hamlets at Timoreng Panua village. The Collecting of Samples using Random Sampling technique and Yount Formula with 10% Standar error, resulting in a sample as much as 55 55 respondents.The data collecting technique of this research is observation, questionnaire, interview and library research. The data analysis of the research used the frecuency distribution tables and simple linaer regresion with SPSS (Statistical Product and Service Solution) 16.0 program for windows.The results showed that the work culture of the effectiveness of public services in the office village ofTimorengPanua,PancaRijang District, SidenrengRappangRegency had a significant influence from the results of calculations in the ANOVA table, t count> t Table or 8.262> 2.672 with a significance level of 0,000 <0, 05, then the decision is Ho “refused” and Ha “accepted”, meaning that work culture (X) has a significant influential on the effectiveness of public service (Y). While the model summary table shows that the influence of work culture (X) on the effectiveness of public service (Y) is 0.563 or 56.3% the category "quite influential". The factors that influence work culture are seen from the first factor that togetherness has an influence of 23.3%. The second factor of intensity has an influence of 30.2%. Keywords : Work Culture, Effectiveness of Public Service.

Styles APA, Harvard, Vancouver, ISO, etc.

20

Cakra, Cakra. « PENGARUH BUDAYA KERJA TERHADAP EFEKTIVITAS PELAYANAN PUBLIK KANTOR DESA TIMORENG PANUA KECAMATAN PANCA RIJANG KABUPATEN SIDENRENG RAPPANG ». PRAJA : Jurnal Ilmiah Pemerintahan 8, n^o 2 (22 juin 2020) : 148–54. http://dx.doi.org/10.55678/prj.v8i2.246.

Texte intégral

Résumé :

Abstract The purpose of this research is to determinate the effect of work culture on the effectiness of public service in the office village of Timoreng Panua, Panca Rijang district, Sidenreng Rappang Regency. The populations of this research is the whole of Family card as much as 547 of 2 hamlets at Timoreng Panua village. The Collecting of Samples using Random Sampling technique and Yount Formula with 10% Standar error, resulting in a sample as much as 55 55 respondents.The data collecting technique of this research is observation, questionnaire, interview and library research. The data analysis of the research used the frecuency distribution tables and simple linaer regresion with SPSS (Statistical Product and Service Solution) 16.0 program for windows.The results showed that the work culture of the effectiveness of public services in the office village ofTimorengPanua,PancaRijang District, SidenrengRappangRegency had a significant influence from the results of calculations in the ANOVA table, t count> t Table or 8.262> 2.672 with a significance level of 0,000 <0, 05, then the decision is Ho “refused” and Ha “accepted”, meaning that work culture (X) has a significant influential on the effectiveness of public service (Y). While the model summary table shows that the influence of work culture (X) on the effectiveness of public service (Y) is 0.563 or 56.3% the category "quite influential". The factors that influence work culture are seen from the first factor that togetherness has an influence of 23.3%. The second factor of intensity has an influence of 30.2%. Keywords : Work Culture, Effectiveness of Public Service.

Styles APA, Harvard, Vancouver, ISO, etc.

21

Savitri, Ary I., Nasim Yadegari, Julia Bakker, Reyn J. G. van Ewijk, Diederick E. Grobbee, Rebecca C. Painter, Cuno S. P. M. Uiterwaal et Tessa J. Roseboom. « Ramadan fasting and newborn's birth weight in pregnant Muslim women in The Netherlands ». British Journal of Nutrition 112, n^o 9 (18 septembre 2014) : 1503–9. http://dx.doi.org/10.1017/s0007114514002219.

Texte intégral

Résumé :

Many Muslim women worldwide are pregnant during Ramadan and adhere to Ramadan fasting during pregnancy. In the present study, we determined whether maternal adherence to Ramadan fasting during pregnancy has an impact on the birth weight of the newborn, and whether the effects differed according to trimester in which Ramadan fasting took place. A prospective cohort study was conducted in 130 pregnant Muslim women who attended antenatal care in Amsterdam and Zaanstad, The Netherlands. Data on adherence to Ramadan fasting during pregnancy and demographics were self-reported by pregnant women, and the outcome of the newborn was retrieved from medical records after delivery. The results showed that half of all the women adhered to Ramadan fasting. With strict adherence to Ramadan fasting in pregnancy, the birth weight of newborns tended to be lower than that of newborns of non-fasting mothers, although this was not statistically significant ( − 198 g, 95 % CI − 447, 51, P= 0·12). Children of mothers who fasted in the first trimester of pregnancy were lighter at birth than those whose mothers had not fasted ( − 272 g, 95 % CI − 547, 3, P= 0·05). There were no differences in birth weight between children whose mothers had or had not fasted if Ramadan fasting had taken place later in pregnancy. Ramadan fasting during early pregnancy may lead to lower birth weight of newborns. These findings call for further confirmation in larger studies that should also investigate potential implications for perinatal and long-term morbidity and mortality.

Styles APA, Harvard, Vancouver, ISO, etc.

22

Hewitt, David J., Sheena K. Aurora, David W. Dodick, Peter J. Goadsby, Yang (Joy) Ge, Robert Bachman, Donna Taraborelli et al. « Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine ». Cephalalgia 31, n^o 6 (7 mars 2011) : 712–22. http://dx.doi.org/10.1177/0333102411398399.

Texte intégral

Résumé :

Background: This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment of migraine. Methods: Multicenter, double-blind, randomized, placebo-controlled, parallel-group, two-stage adaptive study with two interim efficacy analyses to facilitate optimal dose selection. Migraine patients were initially randomized to MK-3207 2.5, 5, 10, 20, 50 and 100 mg or placebo to treat a moderate/severe migraine. One or more doses were to be discontinued based on the first interim analysis and a lower or higher dose could be added based on the second interim analysis. The primary endpoint was two-hour pain freedom. Results: A total of 547 patients took study medication. After the first interim analysis, the two lowest MK-3207 doses (2.5, 5 mg) were identified as showing insufficient efficacy. Per the pre-specified adaptive design decision rule, only the 2.5-mg group was discontinued and the five highest doses (5, 10, 20, 50, 100 mg) were continued into the second stage. After the second interim efficacy analysis, a 200 mg dose was added due to insufficient efficacy at the top three (20, 50, 100 mg) doses. A positive dose-response trend was demonstrated when data were combined across all MK-3207 doses for two-hour pain freedom ( p < .001). The pairwise difference versus placebo for two-hour pain freedom was significant for 200 mg ( p < .001) and nominally significant for 100 mg and 10 mg ( p < .05). The incidence of adverse events appeared comparable between active treatment groups and placebo, and did not appear to increase with increasing dose. Conclusions: MK-3207 was effective and generally well tolerated in the acute treatment of migraine.

Styles APA, Harvard, Vancouver, ISO, etc.

23

D'ANGELINO, JOSÉ LUIZ, MAURÍCIO GARCIA et EDUARDO HARRY BIRGEL. « Productive and reproductive performance in cattle infected with bovine leukosis virus ». Journal of Dairy Research 65, n^o 4 (novembre 1998) : 693–95. http://dx.doi.org/10.1017/s0022029998003124.

Texte intégral

Résumé :

Economic losses caused by enzootic bovine leukosis (EBL) have been of interest since World War II, when the neoplastic form of EBL increased dramatically in Europe. Olson (1974) and House et al. (1975) showed that animals with lymphosarcoma caused by the bovine leukosis virus (BLV) had reduced milk yields, a less efficient reproductive performance and high veterinary costs and mortality rates, while many carcasses were rejected at slaughter. However, the actual impact of BLV infection in cattle without lymphosarcoma is not clear. The purpose of the study reported here was to compare some productive and reproductive responses of cattle that were antibody-positive (BLV+) or negative (BLV−) for BLV.Holstein dairy cows in commercial dairy farms were used in this study. Blood samples were collected and subjected to BLV serological examination by the agar gel immunodiffusion test of Miller & van der Maaten (1976). Animals were then grouped as BLV+ or BLV− according to their serological response to the BLV antigen. Productive and reproductive histories were obtained from individual animal records and the following factors were considered: milk production, calving interval and birth rate. For milk production, we had the daily milk yields of 547 animals, and for calving interval the time between two successive parturitions for 444 cows. These values were examined by ANOVA and when this was significant a Student's t test was carried out for each age group. Birth rates, the percentage of animals that calved in 1 year, were available for 557 animals and were examined with the Z-two proportion test. For all analyses, P<0·05 was considered significant.

Styles APA, Harvard, Vancouver, ISO, etc.

24

Hernandez, Christina S., Michael C. Monuteaux, Richard G. Bachur, Jeanine E. Hall et Pradip P. Chaudhari. « Trends in ED Resource Use for Infants 0 to 60 Days Evaluated for Serious Bacterial Infection ». Hospital Pediatrics 11, n^o 12 (1 décembre 2021) : 1377–85. http://dx.doi.org/10.1542/hpeds.2021-005966.

Texte intégral

Résumé :

OBJECTIVES We examined trends in resource use for infants undergoing emergency department evaluation for serious bacterial infection, including lumbar puncture (LP), antibiotic administration, hospitalization, and procalcitonin testing, as well as the association between procalcitonin testing and LP, administration of parenteral antibiotics, and hospitalization. METHODS We performed a cross-sectional study of infants aged 0 to 60 days who underwent emergency department evaluation for serious bacterial infection with blood and urine cultures from 2010 to 2019 in 27 hospitals in the Pediatric Health Information System. We examined temporal trends in LP, antibiotic administration, hospitalization, and procalcitonin testing from 2010 to 2019. We also estimated multivariable logistic regression models for 2017–2019, adjusted for demographic factors and stratified by age (<28 and 29–60 days), with LP, antibiotic administration, and hospitalization as dependent variables and hospital-level procalcitonin testing as the independent variable. RESULTS We studied 106 547 index visits. From 2010 to 2019, rates of LP, antibiotic administration, and hospitalization decreased more for infants aged 29 to 60 days compared with infants aged 0 to 28 days (annual decrease in odds of LP, antibiotics administration, and hospitalization: 0 to 28 days: 5%, 5%, and 3%, respectively; 29–60 days: 15%, 12%, and 7%, respectively). Procalcitonin testing increased significantly each calendar year (odds ratio per calendar year 2.19; 95% confidence interval 1.82–2.62), with the majority (91.1%) performed during 2017–2019. From 2017 to 2019, there was no association between hospital-level procalcitonin testing and any outcome studied (all P values > .05). CONCLUSIONS Rates of LP, antibiotic administration, and hospitalization decreased significantly for infants 29 to 60 days during 2010–2019. Although procalcitonin testing increased during 2017–2019, we found no association with hospital-level procalcitonin testing and patterns of resource use.

Styles APA, Harvard, Vancouver, ISO, etc.

25

Bhattacharya, A. N., S. Al-Mutairi, A. Hashimi et S. Economides. « Energy and protein utilization of lucerne hay and barley grain by yearling camel calves ». Animal Science 47, n^o 3 (décembre 1988) : 481–85. http://dx.doi.org/10.1017/s0003356100003639.

Texte intégral

Résumé :

ABSTRACTTwo trials were conducted with eight yearling camels with an average intial body weight of 300 kg, to evaluate protein and energy values of lucerne hay and barley grains. In each trial, eight animals were randomly allotted to two different dietary treatments of coarsely ground lucerne hay or lucerne hay + barley grain (50:50) in such a way that two animals in each of the two blocks received the same ration. Each trial consisted of a 10-day preliminary period followed by a 7-day collection period during which total urine and faeces collections were made, and samples were processed and composited for later analysis.All animals consumed daily an average of about 5 kg food divided in two equal meals. The apparent digestibility coefficients for organic matter, crude protein, neutral-detergent fibre and cellulose of the lucerne hay ration improved respectively from 0·615, 0·662, 0·455 and 0·555 to 0·736, 0·655, 0·547 and 0·589, as a result of incorporating 500 g/kg barley grain in place of hay in the diet. Even though there was no difference in the proportion of nitrogen retained relative to intake, the proportion of nitrogen retained relative to that absorbed was higher (P < 0·05) in the lucerne + barley group (0·769) than in the lucerne-only group (0·747). On a dry-matter basis, the feeding value in camels of digestible protein (g/kg), total digestible nutrients (g/kg), digestible energy (MJ/kg), metabolizable energy (MJ/kg), net energy maintenance (MJ/kg), net energy lactation (MJ/kg) and net energy gain (MJ/kg) were respectively 118, 552, 10·0, 8·4, 5·4, 5·0 and 2·1 for lucerne hay and 80, 800, 14·6, 12·1, 8·4, 8·8 and 5·0 for barley grain (calculated by difference).

Styles APA, Harvard, Vancouver, ISO, etc.

26

Johnston, E. A., K. S. Petersen et P. M. Kris-Etherton. « Daily intake of non-fried potato does not affect markers of glycaemia and is associated with better diet quality compared with refined grains : a randomised, crossover study in healthy adults ». British Journal of Nutrition 123, n^o 9 (22 janvier 2020) : 1032–42. http://dx.doi.org/10.1017/s0007114520000252.

Texte intégral

Résumé :

AbstractEpidemiological studies suggest that consumption of potatoes is associated with increased risk of cardiometabolic diseases. However, few clinical trials have empirically tested this. The aim of this single-blind, randomised, crossover study was to evaluate the effect of daily potato consumption, compared with refined grains, on risk factors for cardiometabolic diseases. It was hypothesised that no difference in cardiometabolic endpoints would be detected between conditions, but diet quality would improve with potato consumption. Healthy participants on self-selected diets received one potato-based side dish or one refined grain-based side dish daily, for 4 weeks, separated by a minimum 2-week break. Dishes were isoenergetic, carbohydrate-matched and prepared without excess saturated fat or Na. Participants were instructed to consume the side dish with a meal in place of carbohydrates habitually consumed. Lipids/lipoproteins, markers of glycaemic control, blood pressure, weight and pulse wave velocity were measured at baseline and condition endpoints. Diet quality was calculated, based on 24-h recalls, using the Healthy Eating Index (HEI)-2015. Fifty adults (female n 34; age 40 (sd 13) years; BMI 24·5 (sd 3·6) kg/m2) completed the present study. No between-condition differences were detected for fasting plasma glucose (–0·05 mmol/l, 95 % CI –0·14, 0·04; P = 0·15), the primary outcome or any other outcomes. Compared with refined grains, the HEI-2015 score (3·5, 95 % CI 0·6, 6·4; P = 0·01), K (547 mg, 95 % CI 331, 764, P < 0·001) and fibre (2·4 g, 95 % CI 0·6, 4·2, P = 0·01) were higher following the potato condition. Consuming non-fried potatoes resulted in higher diet quality, K and fibre intake, without adversely affecting cardiometabolic risk.

Styles APA, Harvard, Vancouver, ISO, etc.

27

Fonseca, A. J. M., A. A. Dias-da-Silva et A. L. G. Lourenço. « Effects of maize and citrus-pulp supplementation of urea-treated wheat straw on intake and productivity in female lambs ». Animal Science 73, n^o 1 (avril 2001) : 123–36. http://dx.doi.org/10.1017/s1357729800058124.

Texte intégral

Résumé :

AbstractTwo experiments with lambs given food indoors and individually penned were designed to study the effects of different levels of ground maize and citrus pulp as supplements of a diet based on urea-treated straw (5 kg urea per 100 kg straw) offered ad libitum over a period of 16 weeks (experiment 1) or 10 weeks (experiment 2). The voluntary intake, live-weight gain (LWG), organic matter digestibility (OMD), urinary allantoin-nitrogen (UAN) excretion and acetate clearance rate were measured. The lambs were blocked on weight and randomly assigned to the treatments described below. Ruminal outflow rate of the solid and liquid phases from the rumen were also measured in experiment 2.In experiment 1, 20 female lambs from the Ile-de-France breed, with an initial live weight (LW) of 43 (s.e. 3·3) kg were used. Wheat straw (WS) was supplemented with 50 g/kg of fish meal (FM) and with 0, 100, 200 or 300 g/kg of ground maize on a dry-matter (DM) basis (M0, M1, M2 and M3, respectively). In experiment 2, 25 female lambs from the Portuguese breed Churra-da-Terra-Quente, with an initial LW of 24·2 (s.e. 4·3) kg were used. The straw was offered ad libitum during 10 weeks and supplemented with 50 g/kg of FM and 0, 100, 200, 300, or 400 g/kg of dried citrus pulp on a DM basis (CP0, CP1, CP2, CP3 and CP4, respectively).During the experiments, all animals were moved to metabolism cages to measure OMD and UAN excretion. Two additional incubation studies were carried out with rumen fistulated rams (experiment 1) or cows (experiment 2) given the diets described above close to the maintenance feeding level.In experiment 1 daily straw DM intake linearly decreased (P < 0·05) from 21·6 to 17·7 g/kg LW and LWG linearly increased (P < 0·05) from 51 to 154 g/day for treatments M0, M1, M2 and M3, respectively. The rate of straw DM degradation was significantly decreased (P < 0·01) by maize supplementation. Straw OMD (kg/kg) was 0·562, 0·583, 0·547 and 0·520 and UAN (mg/day) was 620, 790, 854 and 859 for treatments M0, M1, M2 and M3, respectively. Acetate clearance rate, increased (P < 0·05) as the level of maize inclusion increased.In experiment 2 daily straw DM intake was 23·3, 25·8, 24·7, 23·5 and 18·6 g/kg LW per day and LWG was –9, 28, 44, 64 and 67 g/day for treatments CP0, CP1, CP2, CP3 and CP4, respectively. Supplementation significantly increased LWG (P < 0·001) but at the 400 g/kg level depressed straw DM intake. Straw OMD linearly decreased (P < 0·05) from 0·484 (CP0) to 0·428 (CP4) g/kg and UAN (mg/day) was 181, 303, 363, 384 and 392 for treatments CP0, CP1, CP2, CP3 and CP4, respectively. Rumen outflow rate of fibre particles was unaffected by supplementation while the outflow of liquid phase tended to be increased (P < 0·10). The rate of DM degradation was significantly reduced (P < 0·01) by citrus-pulp inclusion. Acetate clearance rate was unaffected (P > 0·05) by citrus-pulp supplementation.The results of these experiments demonstrate that supplementation of urea-treated straw with ground maize up to 200 g/kg or with citrus pulp up to 300 g/kg of the diet DM increased or did not depress straw intake, increased the supply of microbial protein and have no significant effect on straw digestibility. The efficiency of utilization of absorbed energy was apparently improved by maize but not by citrus-pulp supplementation.

Styles APA, Harvard, Vancouver, ISO, etc.

28

Alexander, S. L., C. H. G. Irvine, J. H. Livesey et R. A. Donald. « Effect of isolation stress on concentrations of arginine vasopressin, α-melanocyte-stimulating hormone and ACTH in the pituitary venous effluent of the normal horse ». Journal of Endocrinology 116, n^o 3 (mars 1988) : 325–34. http://dx.doi.org/10.1677/joe.0.1160325.

Texte intégral

Résumé :

ABSTRACT A non-surgical, non-stressful technique was used for collection of pituitary venous blood from five conscious horses every minute for two 10-min periods before and during isolation from the herd, which caused a predictable, yet humane and physiological, emotional stress. Pituitary blood was also sampled every 5 min for two approximately 90-min periods before and after isolation, while jugular blood was sampled every 15 min throughout the experiment. During isolation, all horses became agitated, hyperventilating and sweating. Packed red cell volume increased, as did pituitary venous concentrations of adrenaline (mean ± s.e.m. concentration before isolation, 621·5±112·3 pmol/l; peak during isolation, 2665·4 ± 869·8 pmol/l; P <0·05) and noradrenaline (before, 871·8 ± 111·8 pmol/l; peak, 2726·1 ± 547·4 pmol/l; P<0·02). Concentrations of arginine vasopressin (AVP) were higher in pituitary venous but not in jugular blood during isolation than during the preceding 10-min period (P <0·05). Although AVP secretion increased in all horses, in three of the five it rose dramatically in the first minute of isolation to 25·7 (horse 1), 13·6 (horse 4) and 145·1 (horse 5) times the level in the last sample collected before isolation. Mean pituitary venous concentrations of ACTH and α-MSH increased during isolation in the three horses which had large increases in AVP secretion, but, overall, stress did not significantly affect ACTH or α-MSH secretion. Similarly, mean jugular cortisol levels were not significantly altered by isolation. However, the magnitudes of ACTH, AVP and α-MSH responses to isolation were negatively correlated with the jugular cortisol level before isolation. The changes in pituitary venous concentrations of ACTH and AVP were synchronous under resting conditions, whether samples were collected at intervals of 1 (P <0·01) or 5 (P <0·005) min; however, this synchrony was lost during isolation. The changes in pituitary venous concentrations of ACTH and α-MSH were synchronous both at rest (P <0·025 for 1-min sampling, P <0·01 for 5-min sampling) and during isolation (P<0·01). We conclude that isolation stress increases AVP secretion and may alter the temporal relationship between pituitary venous concentrations of AVP and ACTH. Furthermore, the magnitude of the responses of AVP, ACTH and α-MSH to isolation is significantly affected by the prevailing cortisol level. J. Endocr. (1988) 116, 325–334

Styles APA, Harvard, Vancouver, ISO, etc.

29

Krzakowski, M., J. Douillard, R. Ramlau, J. Jassem, A. Szczesna, P. Zatloukal, J. von Pawel, O. Hansen et X. Sun. « Phase III study of vinflunine versus docetaxel in patients (pts) with advanced non-small cell lung cancer (NSCLC) previously treated with a platinum-containing regimen ». Journal of Clinical Oncology 25, n^o 18_suppl (20 juin 2007) : 7511. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7511.

Texte intégral

Résumé :

7511 Background: Vinflunine (VFL) is a new microtubule inhibitor of the vinca alkaloid class with clinical activity in NSCLC (J. Bennouna, BJC, 2006). Single-agent efficacy and safety of VFL and docetaxel (DTX) were compared in the 2nd line chemotherapy. Methods: Open-label, multi-center, randomised, phase III study in platinum pre-treated locally advanced/metastatic NSCLC pts. At least 275 pts were to be randomized by arm to receive VFL (320 mg/m2, 20-min IV infusion) or DTX (75 mg/m2, 1-hour IV infusion with dexamethasone over 3 days) every 3 weeks. The primary endpoint was progression free survival (PFS), with a non-inferiority analysis based on a 10% difference (types I and II error rates: 5%, 20%). Results: From 06/03 to 03/05, 551 pts were randomized (VFL: 274; DTX: 277) and 547 treated (411 men, 136 women); median age 61 years [range 22–83]; ECOG PS 0–1: 89%; metastatic: 90%. All pts were platinum pre-treated, in combination with a vinca alkaloid (22%), paclitaxel (21%), or gemcitabine (48%). A total of 950 [1–20] and 1,025 [1–18] cycles were given with VFL and DTX respectively. Grade 3/4 toxicities were low in both arms: neutropenia (33% vs 30%), anemia (8% vs 3%), thrombocytopenia (2% vs <1%), febrile neutropenia (3% vs 5%), fatigue (11% vs 6%), vomiting (2% vs 1%), abdominal pain (4% vs <1%), constipation (7% vs <1%). Overall incidence of alopecia was: 20% vs 35%, nail disorders 1% vs 6%, injection site reaction 25% vs 1%, peripheral neuropathy 11% vs 15%, diarrhea 6% vs 12%. Efficacy: All efficacy endpoints were similar: median PFS (2.3 vs 2.3 months, HR:1.004 [95% CI: 0.841–1.199]), independent review response rate (4.4% vs 5.5%), stable disease (36.0% vs 39.6%), disease control (40.4 vs 45.1), median overall survival (6.7 vs 7.2 months, HR: 0.973 [0.805–1.176]). Conclusion: VFL shows efficacy equivalent to docetaxel in 2nd line NSCLC chemotherapy. Low, manageable but different toxicity profiles were observed in either arm. Vinflunine offers a new and useful alternative for the 2nd line treatment of pts with this disease. No significant financial relationships to disclose.

Styles APA, Harvard, Vancouver, ISO, etc.

30

Shingfield, K. J., et N. W. Offer. « Evaluation of the spot urine sampling technique to assess urinary purine derivative excretion in lactating dairy cows ». Animal Science 66, n^o 3 (juin 1998) : 557–68. http://dx.doi.org/10.1017/s1357729800009139.

Texte intégral

Résumé :

AbstractThe potential of the spot urine sampling technique as an alternative to performing a total urine collection was evaluated. Twelve multiparous Holstein-Friesian cows were given two experimental diets in a complete change-over design using two 14-day experimental periods. Experimental diets were either silage offeredad libitumwith 7 kg fresh weight concentrate supplement as a single meal (SF), or a complete diet formulated from the same ingredients with a similar foragexoncentrate ratio (CD). Total urine collections were performed every 2 h on days 11 and 14 of each experimental period. Subsamples of urine were stored at 20°C and subsequently analysed by high-performace liquid chromatography. Daily allantoin and purine derivative (PD) excretion were highly correlated (r = 0·995, no. = 48,P< 0·001). PD and creatinine excretion during each 2-h interval depended on time of collection (PD,P< 0·001 and creatinine,P< 0·05) and on cow (P< 0·01) but were unaffected by sampling day or treatment. Diurnal variations in the molar ratio ofPD or allantoin to creatinine (PD/c and Ale, respectively) followed similar diurnal patterns as observed for PD and allantoin excretion. The data were used to assess the error of prediction of daily mean PD/c or Ale ratios. Three spot sampling regimens (based on the collection of four 4-h samples, three 8-h samples or two 12-h samples) and also on either single or 2-day urine collections were evaluated. Collection of multiple samples within a day was more reliable than collecting fewer samples over several days. Prediction errors were greater for SF compared with CD. Even the most intensive sampling regimen did not allow an acceptable prediction of daily mean PDIc or Ale ratio, minimum r values for PDIc and Ale ratios were 0·098, 0·136 and 0·547, 0·579 for SF and CD, respectively. Furthermore, daily mean PDIc and Ale ratios proved poor predictors of daily PD and allantoin excretion (r values of 0·69 and 0·72, respectively). Total urine collection appears necessary to assess accurately daily PD excretion in dairy cows.

Styles APA, Harvard, Vancouver, ISO, etc.

31

Delgado, Estefan. « EVENTO CEREBROVASCULAR ISQUÉMICO ATEROTROMBÓTICO : ESTUDIO DE CASO ». Universidad Ciencia y Tecnología 24, n^o 103 (10 août 2020) : 28–34. http://dx.doi.org/10.47460/uct.v24i103.354.

Texte intégral

Résumé :

Los eventos cerebrovasculares componen una de las principales causas de defunción en el Ecuador, pese a que la prevención de estas condiciones son conocidas, los factores de riesgos prexistentes coadyuvan a su aparición, conocido como un gran desencadenante de discapacidad, éstos eventos conllevan a padecer trastornos de lenguaje, habla, deglución y voz. La fonoaudiología es la rama de la salud que se dedica a tratar estos trastornos. En la presente investigación se expone un caso, sus manifestaciones y valoraciones clínicas. El caso corresponde a una persona de sexo femenino de 85 años de edad quien padeció de un evento cerebrovascular isquémico aterotrombótico con varias secuelas fonoaudiológicas, se realizó un programa de intervención dirigida a los trastornos secundarios al evento, valorando los resultados posteriores a la intervención temprana, se demuestra la eficacia de la misma. Palabras Clave: evento cerebrovascular, fonoaudiología, trastorno. Referencias [1]L. A. Murria CJ, « Mortality by cause for eight regions of the world: Global burden of disease study.,» Lancet, 1997. [2]Á. M. V., «El accidente cerebrovascular desde la mirada del rehabilitador,» Hospital Clínico Universidad de Chile, 2010. [3]Y. Vega, A. Torres y D. C. Manuel, «Análisis del Rol del Fonoaudiólogo(a) en el Sector Salud en Chile,» Ciencia & Trabajo, vol. 19, nº 59, 2017. [4]A. Chacon, C. Uribe, A. Muñoz, F. Salinas y J. Celis, «Guía de práctica clínica: Enfermedad cerebrovascular.». [5]C. Bargiela y B. M. d. Mar, «Accidente cerebro vascular,» Revista de la Sociedad de Medicina Interna de Buenos Aires, vol. II, pp. 02-05, 2001. [6]D. Moreno, D. Santamaría, C. Ludeña, A. Barco, D. Vásquez y R. Santibañez, «Enfermedad Cerebrovascular en el Ecuador: Análisis de los Últimos 25 Años de Mortalidad, Realidad Actual y Recomendaciones,» Revista Ecuatoriana de Neurología, vol. XXV, pp. 1-3, 2016. [7]J. Rojas, M. Zurru, L. Patrucco, M. Romano, P. Riccio y E. Cristiano, «Registro de enfermedad cerebrovascular isquémica,» Medicina (Buenos Aires), pp. 547-551, 2006. [8]M. Gonzalez, A. Gonzalez, R. Pérez, T. Arrieta y Y. Martínez, «Caracterización del infarto cerebral de etiología aterotrombótica, del territorio carotídeo según tomografía computarizada.,» Revista Cubana de Medicina Militar, nº 4, 2012. [9]J. Fernández, «Enfermedad cerebrovascular: incidencia y tratamiento actual.,» CENIC Ciencias Biológicas, nº 3, pp. 152-178, 2014. [10]F. Silva, J. Zarruk, C. Quintero, W. Arenas, C. Rueda, S. Silva y A. Estupiñán, «Enfermedad cerebrovascular en Colombia,» Revista Colombiana de Cardiología, vol. XII, nº 2, 2006. [11]P. Ayala y Y. Marín, «Realidad Laboral del Fonoaudiólogo en la Unidad de Cuidados Intensivos,» Signos Fónicos, vol. I, nº 1, 2015.

Styles APA, Harvard, Vancouver, ISO, etc.

32

Montard, R., B. Clement, C. Putz, M. Barrali, B. Delbosc et M. Montard. « 547 Manifestations ophtalmologiques de la maladie de Lyme ». Journal Français d'Ophtalmologie 28 (mars 2005) : 300. http://dx.doi.org/10.1016/s0181-5512(05)73667-6.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

33

Mamounas, Eleftherios, Hanna Bandos, Priya Rastogi, Michael R. Crager, Carolyn Mies, Peter C. Lucas, Charles E. Geyer et al. « Abstract PD15-05 : Assessment of estrogen receptor (ESR1) mRNA expression for prediction of extended aromatase inhibitor benefit in HR-positive breast cancer using NRG Oncology/NSABP B-42 ». Cancer Research 82, n^o 4_Supplement (15 février 2022) : PD15–05—PD15–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd15-05.

Texte intégral

Résumé :

Abstract Background: In NSABP B-14, the quantitative levels of ESR1 mRNA, assessed using the standardized 21-gene assay and qRT-PCR platform predicted tamoxifen benefit (interaction p-value <0.001). NSABP B-42 evaluated the effect of extended letrozole in postmenopausal women with hormone receptor-positive breast cancer who have completed 5 years of hormonal therapy with either an aromatase inhibitor or tamoxifen followed by an aromatase inhibitor. We proposed to determine if ESR1 mRNA, reported as the quantitative ER single gene score, is predictive of the magnitude of benefit from extended adjuvant endocrine therapy with letrozole in patients enrolled in NSABP B-42. Methods: This prospectively planned retrospective study used a stratified cohort sample drawn from the 2,589 B-42 patients with available tumor tissue blocks and appropriate consent. All 133 patients who experienced distant recurrence and 48 patients who experienced local/regional but not distant recurrence were included along with a stratified random sample of 547/2,408 patients without recurrence. The primary endpoint was distant recurrence. The primary analysis tested for the interaction between the continuous ER single gene score and the effect of extended letrozole treatment using a weighted Cox proportional hazards regression model. A secondary analysis considered the ER single gene score categorized using the prespecified cutoff of ≤9.1 versus >9.1. Recurrence-free interval was a secondary endpoint. Results: The results of the assay were available for 587 patients. The median ER score was 10.2 (IQR 9.3-11.0). There were 131 patients (23.2% weighted) with ER ≤9.1 and 456 (76.8% weighted) with ER >9.1. No significant interaction of the effect of extended letrozole treatment was found for either the ER single gene score (interaction hazard ratio letrozole vs. placebo with an IQR change in ER score 1.10, 95% CI 0.66 - 1.82, p=.72) or the categories ER ≤9.1 (treatment HR=0.40, 95% CI 0.15-1.06) or ER >9.1 (treatment HR=0.70, 95% CI 0.43-1.12) (interaction p=.32). There was also no apparent prognostic effect of the ER single gene score for distant recurrence with placebo treatment after 5 years of endocrine therapy (p=.12). Results were similar in analyses of any recurrence, analyses adjusting for the proliferation axis from the 21-gene assay, and subgroup analyses by nodal and HER2-status. Conclusions: The B-42 study provided no evidence that ESR1 mRNA as measured by the ER single gene score can inform decisions regarding extended letrozole therapy after 5 years of adjuvant endocrine therapy. Confidence intervals were relatively wide but rule out a strong predictive effect of the ER single gene score in the expected direction. Support: U10CA180868, -180822, U24CA196067; Novartis; Exact Sciences Citation Format: Eleftherios Mamounas, Hanna Bandos, Priya Rastogi, Michael R Crager, Carolyn Mies, Peter C Lucas, Charles E Geyer, Jr, Louis Fehrenbacher, Mark L Graham, Stephen KL Chia, Adam M Brufsky, Janice M Walshe, Gamini S Soori, Shaker R Dakhil, Soonmyung Paik, Sandra M Swain, Frederick L Baehner, Steven Shak, Norman Wolmark. Assessment of estrogen receptor (ESR1) mRNA expression for prediction of extended aromatase inhibitor benefit in HR-positive breast cancer using NRG Oncology/NSABP B-42 [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD15-05.

Styles APA, Harvard, Vancouver, ISO, etc.

34

Papadakis, Emmanouil, Valia Papageorgiou, Konstantinos Tsepanis, Dionysia Theocharidou, Vassilios K. Papadopoulos, Elissavet Georgiou, Smaragda Efraimidou et Anna Kioumi. « Impact of Inherited Thrombophilia Factors On Thrombotic Risk in Patients with Newly Diagnosed BCR- Abl (-) Myeloproliferative Disorders ; Finally a Role of MTHFR- C677T Polymorphism ? » Blood 120, n^o 21 (16 novembre 2012) : 5065. http://dx.doi.org/10.1182/blood.v120.21.5065.5065.

Texte intégral

Résumé :

Abstract Abstract 5065 Introduction: Myeloproliferative Neoplasms (MPN) are commonly associated with thrombotic complications, which constitute the major cause for morbidity and mortality in these patients. While the pathogenesis of Thrombosis is not yet fully elucidated, the impact of inherited thrombophilia on MPN patients is unknown. MTHFR-C677T polymorphism is a usual variation of the MTHFR gene and exerts weak, if any, prothrombotic role mainly through increased homocysteine levels. Up to date there are no specific guidelines for treatment of thrombotic events in MPN patients. Objectives: The purpose of our study is to determine the impact of inherited thrombophilia factors on thrombotic risk in patients with newly diagnosed BCR- abl (-) myeloproliferative neoplasms. We also tried to assess the role of the MTHFR- C677T polymorphism in thrombotic risk in our MPN patients. Material and Methods: Our study population consisted of 68 patients diagnosed with BCR- abl (-) myeloproliferative neoplasms in the Hematology Department of our Hospital during the period 2005– 2008. Diagnosis was set according to the World Health Organization and Updated European Clinical and Pathological criteria for the Diagnosis, Clasification and Staging of the Philadelphia chromosome (-) chronic myeloproliferative disorders. Age, Sex, Platelet count, serum homocysteine levels, presence of Jak-2 mutation, together with genetic polymorphisms of Factor V-Leiden and FII- G121120A prothrombin mutations, and MTHFR- C677T polymorphism were assessed. Among our patients, whose median age was 65 years (range 21– 83), 40 were male and 28 female. 41 patients were diagnosed with essential thrombocythemia (ET), 22 with Polycythemia Vera (PV), 3 with essential myelofibrosis and 2 with Unclassified Chronic bcr- abl (-) MPN. Statistical analysis was conducted with SPSS 20. 0. At first a monovariate statistical model was used with significant level set at p= 0. 05. For the multivariable statistical analysis model we used all variables with p<0, 05 from the previous model and those mentioned at recent medical literature as significantly related with thrombotic risk. Results: From our patients, 31 suffered a thrombotic event (arterial or venous thrombosis, microvascular disorders). Regarding their thrombophilia profile patients were found to be: 4 carriers of the FVL mutation, 4 carriers of the FII- G121120A and 13 were carrying the MTHFR- C677T polymorphism. Moreover, 56 patients were tested for Jak-2V617F, and 42 of them were found to be positive (100% patients with P. V., 79% ET patients). We tried to define whether the following variables are high risk factors for thrombotic events in our population: Platelet count, serum homocystein levels, presence of Jak-2 mutation, Factor V-Leiden and FII- G121120A, mutations, and MTHFR- C677T. Surprisingly, the presence of MTHFR- C677T reached statistical significance on the monovariate analysis (p= 0. 001), while published data on general thrombosis population don't show any correlation of the MTHFR- C677T with thrombotic events. Jak-2 mutation was studied in a subgroup of patients, which didn't include patients with PV and was found to be statistically significant thrombosis risk factor in the monovariate analysis. Multiple regression analysis revealed MTHFR- C677T genetic polymorphism as independent risk factor concerning thrombotic events in patients with BCR- abl (-) MPNs (p= 0. 01, Exp (B)= 39. 227, 95%CI: 2. 41 –638. 547). The mean concentration of serum homocystein and the mean platelet count didn't show any statistically significant difference between patients carying MTHFR- C677T polymorphism and MTHFR- C677T negative patients. So serum homocystein levels and platelet count were not found to be confounding factors. In addition the co- existence of MTHFR- C677T with either G121120A or FVL mutations was detected in 4 patients, and all of them suffered from thrombotic events. Conclusions: Our study is the first to demonstrate a prothrombotic role of MTHFR- C677T polymorphism in a MPN population. Thrombophilia studies are needed in MPN patients in order to better assess the thrombotic risk for the patients but foremost to properly tailor anticoagulant treatment after a thrombotic episode. Disclosures: No relevant conflicts of interest to declare.

Styles APA, Harvard, Vancouver, ISO, etc.

35

Thomas, Deborah A., Stefan Faderl, Jorge Cortes, Susan O’Brien, Francis Giles, Guillermo Garcia, Steven Kornblau et al. « Update of the Hyper-CVAD and Imatinib Mesylate Regimen in Philadelphia (Ph) Positive Acute Lymphocytic Leukemia (ALL). » Blood 104, n^o 11 (16 novembre 2004) : 2738. http://dx.doi.org/10.1182/blood.v104.11.2738.2738.

Texte intégral

Résumé :

Abstract The intensive combination chemotherapy program hyper-CVAD in newly diagnosed Ph+ ALL yields complete remission (CR) rates of 90%, but remissions are brief with median CR duration of 16 months [Kantarjian et al, JCO 18:547, 2000]. The activity of the tyrosine kinase inhibitor imatinib given as a single agent in relapsed or refractory Ph+ ALL or chronic myelogenous leukemia in lymphoid blast phase was 20% [Druker et al, NEJM 344:1084, 2001]. A phase II trial of imatinib and hyper-CVAD was conducted in newly diagnosed Ph+ ALL. Imatinib was given 400 mg days 1–14 of each course of therapy (fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate and ara-C). Preliminary results were published in the first 20 patients (pts) treated, with CR rates of 100% in the de novo group, and improvement of disease-free survival (DFS) compared with hyper-CVAD alone [Thomas et al, Blood 103:4396, 2004]. To date, 32 pts with Ph+ ALL have been treated from April 2001 to February 2004. Twenty-six patients had active disease, either untreated (n=21) or refractory (n=5) to one induction course without imatinib. Six pts were in CR at study entry after one induction course without imatinib mesylate. Median age was 48 years (range, 17–75); 59% were male. Five had CNS disease (16%). Twenty-five of 26 pts (96%) with active disease at study entry achieved CR (1 failed to meet platelet criteria for CR). Median days to response was 21 days. Two of 26 pts (8%) required 2 courses to achieve CR. Allogeneic stem cell transplant (SCT) was performed in 13 pts in CR within a median of 3 months from start of therapy (range, 1–12). After a median follow-up of 2 years (range, 4–36 months), 1 primary refractory pt relapsed at 12 mos (bcr-abl/abl RT-PCR ratio <.05 at 9 mos), 1 pt relapsed day 149 after matched related SCT despite negative nested PCR for bcr-abl, and 2 pts changed therapy after 5 mos for persistent marrow Ph+ metaphases without overt leukemia relapse. Five pts died in CR, 3 older pts related to comorbid conditions (2 were negative for bcr-abl by nested PCR) and 2 related to complications of allogeneic SCT. Molecular response rate (negative bone marrow RT-PCR for bcr-abl confirmed by nested PCR) was approximately 50% in 19 pts who did not undergo allogeneic SCT. Outcome appears better with the hyper-CVAD and imatinib regimen with 2-year DFS rates of 87% (all pts) compared with 28% for hyper-CVAD alone or 12% for VAD (p<.001). Unexpected toxicities related to the addition of imatinib mesylate were not observed. The hyper-CVAD and imatinib regimen with or without allogeneic SCT continues to appear promising with additional accrual and longer follow-up.

Styles APA, Harvard, Vancouver, ISO, etc.

36

Amiri-Kordestani, Laleh, Xin Gao, Shrujal Baxi, Erik Bloomquist, Jonathan Bryan, Lynn Howie, Catherine Keane et al. « Abstract P2-11-05 : Generating real-world external comparators for randomized clinical trials (RCTs) in metastatic breast cancer (mBC) using electronic health records (EHRs) ». Cancer Research 82, n^o 4_Supplement (15 février 2022) : P2–11–05—P2–11–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-11-05.

Texte intégral

Résumé :

Abstract Objectives: Real-world data (RWD) from the routine care of patients with cancer captured through EHRs is a valuable resource for research. Understanding the relationship between characteristics and outcomes of patients treated in the real world and those treated in clinical trials is essential to produce evaluable trial-like populations using RWD in oncology for research and regulatory purposes. Methods: This study used: a) RWD from the Flatiron Health EHR-derived, de-identified, longitudinal database (comprising patient-level structured and unstructured data, curated via technology-enabled abstraction selected from approximately 280 US cancer clinics [~800 sites of care]) and b) patient-level data from three completed RCTs (PALOMA-2, MONALEESA-2, and MONARCH-3) including patients with previously untreated hormone receptor positive (HR+), HER2/neu negative (HER2-) mBC, then separately pooled across the trials into two treatment groups, patients who received aromatase inhibitor monotherapy (AI) or a CDK4/6 inhibitor + AI. Key eligibility criteria were similar across the RCTs and were used to select a real world external cohort (rwEC) initiating AI monotherapy on or prior to 11 Nov 2015 (end of MONARCH-3 enrollment period). Patients from the rwEC were matched separately to the control arm and experimental arm patients from the pooled RCT using propensity score method (PSM). The propensity score was estimated by a logistic regression using baseline covariates of age, race, site of disease (visceral, non-visceral), Eastern Cooperative Oncology Group Performance Status (ECOG PS) (0, 1), and metastatic disease (recurrent, new). The matching ratio was 1:1 without replacement with calipers. Covariate balance was measured by the absolute standardized mean difference (ASMD). Due to the high percentage of missing ECOG PS data, matching was repeated 100 times with imputed ECOG PS. The impact of including additional key covariates for propensity matching such as number of disease sites, bone-only disease, and prior endocrine therapy was assessed. Results: There were 1326 patients with HR+, HER2- mBC selected from the EHR-derived database who received first-line AI therapy and 1827 patients randomized in the RCTs (1106 and 721 patients for experimental and control arms, respectively). With 100 matching iterations, 563 rwEC patients on average (range, 547-572) were matched to the RCTs control arm, and 753 rwEC patients on average (range: 741-761) were matched to the RCTs experimental arm. Prior to matching, the ASMD varied widely across all prespecified baseline covariates (4.3 for the rwEC vs. RCTs control arm, 2.6 for the rwEC vs. RCTs experimental arm). After matching was performed, across all baseline covariates used in the PSM, the ASMD was reduced to be under 0.12 for the rwEC vs. RCTs control arm, and under 0.2 for the rwEC vs. RCTs experimental arm in more than 90% of the matching iterations. Analyses looking at the additional baseline covariates to the propensity matching resulted in similar ASMDs. Conclusions: EHR-derived RWD can be used to generate a cohort of patients with similar baseline characteristics to those treated on RCT. The next step in our trial emulation framework is to analyze the comparability of outcomes between these two matched cohorts. Citation Format: Laleh Amiri-Kordestani, Xin Gao, Shrujal Baxi, Erik Bloomquist, Jonathan Bryan, Lynn Howie, Catherine Keane, Paul G. Kluetz, Christy Osgood, Prashni Paliwal, Donna R. Rivera, James Roose, Julie Schneider, Harpreet Singh, Shenghui Tang, Lijun Zhang, Julia A. Beaver. Generating real-world external comparators for randomized clinical trials (RCTs) in metastatic breast cancer (mBC) using electronic health records (EHRs) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-11-05.

Styles APA, Harvard, Vancouver, ISO, etc.

37

Debus, J. « P-547 Epoetin alfa and survival in patients with non-resectable NSCLC-Interimresults ». Lung Cancer 49 (juillet 2005) : S261. http://dx.doi.org/10.1016/s0169-5002(05)81040-2.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

38

Cipriano, Jailson Araujo, et Lívia da Conceição Costa Zaqueu. « A dupla excepcionalidade altas habilidades/superdotação associada ao transtorno do espectro autista : compreendendo as especificidades ». Conjecturas 22, n^o 1 (28 janvier 2022) : 1023–41. http://dx.doi.org/10.53660/conj-547-802.

Texte intégral

Résumé :

RESUMO Este artigo científico teve como objetivo produzir um Estado da Arte sobre a temática da Dupla Excepcionalidade (D.E) em pessoas com altas habilidades com transtorno do espectro autista nível 1. Trata-se de uma pesquisa bibliográfica, qualitativa e de cunho exploratório. Foi utilizada a técnica de análise de conteúdo de Bardin (2011) para a análise de dados. À luz dos autores até aqui estudados podemos verificar que dos 09 (nove) artigos, 05 (cinco) deles são de revisão e 04 (quatro) são de pesquisa aplicada, o que coaduna com a literatura que aponta a necessidade de mais pesquisas aplicadas sobre o assunto. Foram analisados nove artigos segundo critérios preestabelecidos. As características mais presentes de maior incidente apontadas pelos autores foram: fraca capacidade de interação social, dificuldade de ser empático foco intenso naquilo em que lhes interessam e assincronia entre o desenvolvimento cognitivo motor e o Desenvolvimento Social e afetivo. Palavras-chave: Dupla Excepcionalidade; Transtorno do Espectro Autista nível 1; Altas Habilidades/Superdotação; Estado da Arte; Educação Especial e Inclusiva.

Styles APA, Harvard, Vancouver, ISO, etc.

39

Thomas, Deborah A., Susan O'Brien, Michael Rytting, Farhad Ravandi, Elias Jabbour, Alessandra Ferrajoli, Zeev Estrov et al. « Incidence of Central Nervous System (CNS) Relapse in De Novo Adult Acute Lymphoblastic Leukemia (ALL) ». Blood 124, n^o 21 (6 décembre 2014) : 940. http://dx.doi.org/10.1182/blood.v124.21.940.940.

Texte intégral

Résumé :

Abstract In the era of improved outcomes with systemic chemotherapy for de novo adult ALL, prevention of CNS relapse becomes even more paramount. Isolated CNS relapse may herald eventual marrow relapse in the absence of definitive CNS-directed and systemic chemotherapy strategies. CNS prophylaxis can be successfully achieved with intrathecal chemotherapy treatments (IT) in conjunction with systemic chemotherapy inclusive of high-dose methotrexate (MTX) and/or high-dose cytarabine (ara-C) without use of radiation therapy (XRT). The hyper-CVAD regimen (cycles of fractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone alternating with cycles of high dose MTX (1 g/m2) and cytarabine (3 gm/m2; 1 gm/m2 for age > 60 yrs) incorporates IT MTX alternating with IT ara-C during the intensive phase of induction-consolidation. The number of IT treatments was determined by CNS risk (4 IT for low risk = LDH < 1400 U/L and low proliferative index; 16 IT for high risk = LDH > 1400 U/L or high proliferative index; 8 IT for indeterminate risk = one of parameters unknown). An analysis performed in 2000 (Kantarjian et al, J Clin Oncol 18: 547, 2000) identified CNS relapse rates of 6%, 2%, and 0% for the low, high, and indeterminate CNS risk groups, respectively. The number of IT administered was modified from 4 to 6, from 16 to 8, and maintained at 8 for these CNS risk groups, respectively, until 2010, at which point all pts received 8 IT. An analysis was conducted to examine the incidence of CNS relapse for 565 pts with de novo ALL treated with hyper-CVAD-based regimens (n=453, inclusive of nelarabine, monoclonal antibodies such as rituximab, ofatumumab or inotuzumab, and/or tyrosine kinase inhibitors such as imatinib, dasatinib or ponatinib) from 2001 to 2014 or with the augmented BFM regimen (one IT ara-C, 15 IT MTX, Capizzi methotrexate) (n=112) from 2006 to 2014. T-lymphoblastic lymphoma (designated for 8 IT) and Burkitt leukemia/lymphoma (designated for 16 IT) cases were excluded from the analysis. The incidence of CNS relapse (n=42) was 7% overall; 59% were isolated CNS relapses (n=25, 5%) without concurrent marrow relapse. Median time to isolated CNS relapse was 19 mos versus 10 mos for concurrent relapse. The incidence of CNS relapse for cases with CNS disease at initial presentation (n=70) was 19%. Factors predictive of higher incidence of CNS relapse included younger age (12% for 30 yrs or younger, 3.5% for 60 yrs or older, p=.01), elevated LDH > 1400 U/L (13% vs 4%, p<.001), and Philadelphia chromosome positivity (12% vs 6%, p=.05). The overall CNS relapse rates were 4% for the hyper-CVAD and monoclonal antibody regimens; 11% for the augmented BFM regimen, and 14%-15% for the hyper-CVAD and imatinib/dasatinib regimens. The CNS relapse rate declined from 10% for pts treated prior to 2010 to 8% thereafter (8 IT for all risk groups). Overall, the 3-yr survival rates for CNS relapse was 47% vs 63% without CNS relapse (p=0.006). Modifications to the hyper-CVAD and tyrosine kinase inhibitor regimens for Philadelphia positive ALL have been implemented to increase the number of IT from 8 to 12. Similar modifications will be implemented for the augmented BFM regimen with consideration for incorporation of high dose MTX. Additional analyses will further refine the CNS risk model in order to guide CNS prophylaxis. Alternative agents such as IT rituximab may improve outcomes for CD20 positive cases with CNS disease at presentation; a clinical trial in the setting of active CNS disease is underway. Disclosures No relevant conflicts of interest to declare.

Styles APA, Harvard, Vancouver, ISO, etc.

40

Thomas, Deborah A., Hagop M. Kantarjian, Jeffrey L. Jorgensen, Stefan Faderl, Elias Jabbour, Marina Konopleva, Farhad Ravandi et al. « Outcomes Continue to Be Favorable for De Novo Philadelphia Chromosome Negative B-Lymphoblastic Leukemia (ALL) After Therapy with Hyper-CVAD (with or without Rituximab) Regimen ». Blood 120, n^o 21 (16 novembre 2012) : 3572. http://dx.doi.org/10.1182/blood.v120.21.3572.3572.

Texte intégral

Résumé :

Abstract Abstract 3572 The hyper-CVAD regimen [Kantarjian, JCO 18: 547, 2000; Kantarjian, Cancer 101: 2788, 2004] includes intensive cycles of hyper-CVAD (fractionated cyclophosphamide, vincristine [VCR], doxorubicin, dexamethasone) alternating with high dose methotrexate (MTX) and cytarabine every 21 days for 8 courses, followed by maintenance therapy with POMP (6-mercaptopurine, MTX, VCR, prednisone) interrupted by early and late intensifications. The regimen was modified in 1999 to include use of laminar air flow rooms during the induction phase for patients (pts) aged 60 years or older. Therapeutic modifications included rituximab 375 mg/m2 (Days 1 & 11 of hyper-CVAD, Days 1 & 8 of MTX-cytarabine for 8 total doses) for CD20 expression > 20% to counteract increased propensity for relapse [Thomas D, Blood 113: 6330, 2009], early anthracycline intensification with liposomal daunorubicin-cytarabine from 1999–2000 only [omitted thereafter owing to lack of benefit, Thomas D, Cancer 116: 4580, 2010], augmentation of CNS prophylaxis, and extension of maintenance POMP therapy from 24 to 30 months with additional early and late intensifications [details in Thomas D, JCO 28: 3830, 2010]. Overall, 216 pts with Ph negative B-lymphoblastic leukemia have been treated with the modified hyper-CVAD regimens. Median age was 46 years (range, 16–84). For the CD20 positive B-lymphoblastic subset treated with hyper-CVAD and rituximab 3-yr rates of CR duration (CRD) and survival (OS) were 66% and 57%. In the younger (age < 60 years) CD20-positive subset, rates of CRD and OS were superior compared with standard hyper-CVAD (69% v 38%; P <.001% and 71% v 47%, P =.003). Historical experience in 37 adolescent and young adult (AYA) subset aged 15 – 30 yrs with CD20 positive B-lymphoblastic leukemia (prior to shift to augmented BFM regimen as first line therapy) showed that the addition of rituximab improved 3-yr CRD rates from 26% to 60% (P =.001) and 3-yr OS rates from 47% to 70% (P =.05) compared with standard hyper-CVAD without rituximab. There were no significant differences in outcome for this AYA subset by regimen (standard or modified) for the CD20 negative groups (all 3-yr rates > 70%). Elderly pts aged 60 year or older with CD20 positive B-lymphoblastic leukemia treated with hyper-CVAD and rituximab, in contrast to the Burkitt experience, had outcomes which were similar to the historical experience with standard hyper-CVAD (rates of CRD 59% v 50%, P = NS and OS 23% v 32%, P = NS, respectively), despite high rates of negativity for minimal residual disease (MRD) by multiparameter flow cytometry (MFC) at CR, related mainly to deaths in CR during consolidation. MRD positivity by MFC after induction therapy with hyper-CVAD and rituximab was associated with a higher relapse rate and lower 3-yr CR duration rates compared with MRD negative status at the time of CR. Additional doses of rituximab were added to consolidation (Day 1 of cycles 5 – 8) and maintenance chemotherapy in order to potentially improve outcomes for the MRD positive subset. Upfront dose reductions of cyclophosphamide, doxorubicin, vincristine, dexamethasone and methotrexate have been implemented for all cycles of induction-consolidation phase for older age and/or poor performance status with reduction in rate of deaths in CR noted. Incorporation of pegylated asparginase (one dose of 2000 Units/m2 with capping per cycle, 1000 Units/m2 if older or poor performance status) during the induction-consolidation phase (“augmented hyper-CVAD”) was piloted as first line therapy in 19 pts aged 30 – 59 years of age, then omitted owing to excessive toxicity. Incorporation of rituximab into first line intensive chemotherapy such as the hyper-CVAD regimen appears beneficial for younger pts, prompting investigation of second generation anti-CD20 monoclonal antibodies such as ofatumumab and hyper-CVAD (regardless of CD20 expression owing to data showing upregulation of CD20 expression) for the younger subsets and inotuzumab (with or without rituximab) and “mini-hyper-CVAD” for the elderly group. Multivariate analysis of outcomes by risk groups (age/MRD status/CD20 expression) and the impact of the early/late intensifications during maintenance chemotherapy will be presented. Disclosures: O'Brien: Genentech: Consultancy, Membership on an entity's Board of Directors or advisory committees.

Styles APA, Harvard, Vancouver, ISO, etc.

41

Farinha Rodrigues, Célia Regina, et Samara Jamile Mendes. « Implicações do financiamento do tratamento oncológico no SUS e a sua judicialização ». JMPHC | Journal of Management & ; Primary Health Care | ISSN 2179-6750 14, spec (19 septembre 2022) : e014. http://dx.doi.org/10.14295/jmphc.v14.1220.

Texte intégral

Résumé :

No contexto recente, o financiamento do Sistema Único de Saúde – SUS tem gerado inúmeros debates acerca de sua tendência de tornar-se cada vez mais insuficiente, sendo considerado por muitos como subfinanciamento ou desfinanciamento, o que poderá acarretar em um aniquilamento da manutenção de um sistema universal de saúde. Esse processo de desfinanciamento tem como principal símbolo a Emenda Constitucional – EC n. 95/2016, que limita a expansão dos gastos públicos pelos próximos 20 anos, baseada no valor das despesas de 2017. Pesquisa publicada em 2016 estimou uma diminuição do recurso em cerca de R$ 318 bilhões entre 2003 e 2015, caso a medida tivesse sido implementada em 2003, o que corresponde a três anos de orçamento, tendo como base o ano de 2015. Em um cenário de escassez de recursos, chama a atenção a evolução de gastos na aquisição de medicamentos no SUS. No Brasil, enquanto os gastos totais com saúde aumentaram em 9,6% entre os anos de 2002 e 2006, os gastos com medicamentos tiveram um incremento de 123,9%, impulsionados principalmente por terapias relacionadas à média e alta complexidade. A evolução dos gastos com medicamentos e sua contribuição para ampliação da cobertura e melhoria do acesso a medicamentos pela população deve ser observada de maneira criteriosa, porque parte dessa demanda inclui as despesas com medicamentos adquiridos em razão de decisões judiciais. Com relação aos gastos com ações judiciais do governo federal entre os anos de 2010 e 2016, houve um crescimento do gasto de 547% e tem preocupado gestores públicos pelo potencial de produzir iniquidades no SUS. Ao se explorar os dados de publicações referentes às ações judiciais, observa-se que a oncologia é responsável por parte significativa do número de ações judiciais, assim como das despesas relacionadas ao atendimento dessa demanda. Considerando o atual modelo de financiamento do atendimento oncológico, no qual os serviços especializados são ressarcidos por Autorização de Procedimentos Ambulatoriais – APAC, com o valor global de atendimento, sem o estabelecimento de uma relação de medicamentos e desvinculada da Assistência Farmacêutica, este trabalho tem como objetivo identificar a relação entre a judicialização e o financiamento do tratamento oncológico no SUS. Trata-se de revisão integrativa da literatura utilizando-se as bases de dados da Biblioteca Virtual em Saúde – BVS e SciELO. Os descritores foram definidos através da pergunta da pesquisa, o que possibilitou a formulação da sintaxe alinhada aos objetivos propostos nesta revisão. A pergunta da pesquisa norteadora desta revisão é: O que a literatura científica relata sobre a relação entre o financiamento no tratamento oncológico no SUS e sua judicialização? Utilizou-se a técnica de funil, combinando-se diversos descritores relacionados ao tema. Buscou-se descritores representantes das áreas temáticas, oncologia representando a população, judicialização representando o fenômeno e financiamento representando o contexto. Os descritores foram identificados através da plataforma Descritores em Ciências da Saúde – DeCS, e selecionados de acordo com o escopo de definição dos mesmos. Foram efetuadas buscas individuais para cada descritor identificado e desenvolvidas sintaxes com o operador boleano “OR” para cada grupo temático. As pesquisas foram realizadas no dia 01 de fevereiro de 2022 na base de dados BVS e após definição da sintaxe final, foi aplicada na base de dados SciELO em 05 de fevereiro de 2022. Ao agrupar-se as sintaxes dos três eixos temáticos, utilizando-se o operador booleano “AND” foram identificadas apenas quatro publicações. Prosseguiu-se, portanto, a novas testagens visando que a sintaxe obtivesse um maior número de publicações, resultando na seguinte sintaxe: ("judicialização") OR ("Decisões Judiciais") AND ("oncologia") OR ("Antineoplásicos") OR ("neoplasia"). Após a definição da sintaxe final, efetuou-se a busca nas bases de dados BVS, a qual resultou em 328 publicações e na base de dados SciELO resultando em 172 publicações até a data de 05 de fevereiro de 2022, utilizando-se o critério de “Título, Resumo e Assunto” na base de dados BVS e “todos os índices" na base de dados SciELO. As publicações foram extraídas utilizando-se os filtros presentes na BVS e SciELO para seleção do tipo de publicação ao optar-se somente pelos artigos, do total de 500 publicações identificadas, 77 foram excluídas por tipo. A análise dos artigos duplicados foi realizada utilizando-se a ferramenta Zotero e 107 excluídas por repetição. Procedeu-se a avaliação dos títulos dos 316 artigos aplicando-se critérios de inclusão e exclusão, nesta etapa 257 artigos foram excluídos, resultando em 59 artigos para apreciação dos resumos. Após leitura dos resumos, 51 foram excluídos por divergirem do escopo proposto nesta revisão integrativa. Ao final, oito artigos foram selecionados para composição deste estudo e todos encontram-se integralmente disponíveis. Os artigos selecionados foram publicados entre os anos de 2007 e 2017. Os principais editoriais de publicação dos artigos selecionados são a “Revista de Saúde Pública” e o “Caderno Ibero Americano de Direito Sanitário”. Cinco artigos debatem a judicialização de medicamentos, em especial os antineoplásicos, em relação a estruturação da Assistência Farmacêutica e como a lógica de fornecimento de medicamentos não incorporados ao SUS pode comprometer a gestão orçamentária e gerar iniquidades. Um artigo discute especificamente o uso de medicamentos antineoplásicos off-label em ações judiciais. Dois artigos discutem a relação entre a judicialização e a incorporação de novas tecnologias, principalmente sobre o tempo oneroso na incorporação, o que limita o atendimento aos pacientes oncológicos. Outros ainda sobre como a judicialização pode forçar a incorporação de tecnologias. Como considerações preliminares, observa-se que embora a judicialização traga inúmeros debates e dificuldades na gestão do SUS, poucos estudos buscam compreender suas possíveis causas e pontos focais estratégicos para uma possível solução.

Styles APA, Harvard, Vancouver, ISO, etc.

42

MARTINELI, Telma Adriana Pacifico, Carolina De Moura VASCONCELOS et Eliane Maria de ALMEIDA. « CONCEPÇÃO PEDAGÓGICA E CURRICULAR PARA O ESPORTE NA BASE NACIONAL COMUM CURRICULAR ». Trama 14, n^o 33 (2 octobre 2018) : 106–17. http://dx.doi.org/10.48075/rt.v14i33.19528.

Texte intégral

Résumé :

O estudo teve objetivo analisar a BNCC para o Ensino Fundamental, em seus aspectos pedagógicos e curriculares, com foco na Educação Física e na concepção e classificação do esporte. Tratou-se de um estudo bibliográfico e documental fundamentado em uma perspectiva histórica- crítica. No documento, a Educação Física é um componente curricular que permite a aprendizagem de práticas corporais: brincadeiras e jogos, ginásticas, dança, lutas, práticas corporais de aventura e esportes. Essa concepção fundamenta-se na Praxiologia Motriz, que estuda a lógica interna e externa dos jogos e esportes, a partir da cooperação, interação com o adversário, desempenho motor e objetivos táticos da ação, na tentativa de romper com a perspectiva positivista, busca-se na linguagem e no significado da ação motriz uma vertente social do esporte. Essa concepção pelo viés da motricidade, continua se perpetuando na Educação Física, repercutindo na BNCC e contrariando as críticas histórias.REFERÊNCIASARAÚJO P. A., RIBAS, J. F. M. Contribuições da praxiologia motriz para a abordagem crítico-superadora. Disponível em: https://repositorio.ufsm.br/bitstream/handle/1/881/Araujo_Pablo_Aires.pdf?sequence=3. Acesso em: 20/03/2017.BETTI, Mauro. Por uma Teoria da Prática. Motus Corporis. Rio de Janeiro, v. 3, n. 2, p. 73-127, dez. 1996.BITTENCOURT, J. A base nacional comum curricular: uma análise a partir do ciclo de políticas. In: XIII Congresso Nacional de Educação. Anais do EDUCERE. Paraná, 2017. BRASIL. Base Nacional Comun Currícular. Ministerio da Educação. Brasília, DF, 2018. Disponivel em: http://basenacionalcomum.mec.gov.br/wp-content/uploads/2018/02/bncc-20dez-site.pdf. Acesso em: 07/08/2018.KUNZ, E. Transformação didático-pedagógica do esporte. Ijuí: Editora Unijuí, 1994.MARTINELI, T. A. P.; MAGALHÃES, C. H.; MILESKI, K. G.; ALMEIDA, E. M.. A Educação Física na BNCC: concepções e fundamentos políticos e pedagógicos. Motrivivência. Santa Catarina, v. 28, n. 48, p. 76-95, setembro/2016. Disponível em: https://periodicos.ufsc.br/index.php/motrivivencia/article/view/2175-8042.2016v28n48p76/32564 Acesso em: 09/08/2018.MELLO, R. A. A necessidade da Educação Física na escola. São Paulo: Instituto Lukács, 2014.MOREIRA, L. R.et al. Apreciação da Base Nacional Comum Curricular e a Educação Física em foco. Motrivivência, v. 28, n. 48, p. 61-75, setembro/2016.NEIRA, M. G.; JUNIOR, M. S. A Educação Física na BNCC: procedimentos, concepções e efeitos. Motrivivência. Santa Catarina, v. 28, n. 48, p. 188-206, setembro/2016. Disponível em: https://periodicos.ufsc.br/index.php/motrivivencia/article/view/45356 Acesso em: 09/08/2018.NORA, D. D.; WALTER, J; BUFFON, E.; RIBAS, J. F. M. Praxiologia motriz, trabalho pedagógico e didática na educação física. Movimento, Porto Alegre, v. 22, n. 4, 1365-1378, out./dez. de 2016. Disponível em: http://seer.ufrgs.br/index.php/Movimento/article/view/65268. Acesso em: 21/03/2018.OLIVEIRA, G. T; RIBAS, J. F. M. Articulações da praxiologia motriz coma Concepção Crítico-Emancipatória. Movimento, Porto Alegre, v. 16, n. 01, p. 131-148, jan./mar. 2010. Disponível em: http://www.seer.ufrgs.br/Movimento/article/viewFile/9680/7521. Acesso em: 03/05/2018.OLIVEIRA, A. A. B; PERIM, G. L. Fundamentos Pedagógicos do Programa Segundo Tempo. Maringá: EDUEM, 2009.PARLEBAS, P. Eléments de sociologie du sport. Revue française de sociologie. França, n. 3, v. 28, p. 547-550, 1987.PAULO-NETTO, J. Introdução ao estudo do método de Marx. São Paulo: Editora Expressão Popular, 2011.PIAGET, J. A Epistemologia genética; Sabedoria e ilusões da filosofia. São Paulo: Abril Cultural, 1983.PIMENTEL, A. O método da análise documental: seu uso numa pesquisa historiográfica. Cadernos de Pesquisa, n. 114, p. 179-195, novembro/ 2001. Disponível em: http://www.scielo.br/pdf/cp/n114/a08n114.pdf .Acesso em: 03/08/2018.RENE, B. X. L’education physique Au XX e Siecleen France. Paris: Nouvelle, 1994.RIBAS, J. F. M. Praxiologia Motriz: construção de um novo olhar dos jogos e esportes na escola. Motriz, Rio Claro, v.11 n.2 p.113-120, mai./ago. 2005. Disponível em: http://www.rc.unesp.br/ib/efisica/motriz/11n2/10MRJ.pdf . Acesso em: 20/03/2017.RIBAS, J. F. M. O voleibol e os novos olhares dos jogos esportivos coletivos. In: RIBAS, J. F. M (Org.). Praxiologia motriz e voleibol: elementos para o trabalho pedagógico. Ijuí: Editora Unijuí, p. 21-56, 2014.RODRIGUES, A. T. Base Nacional Comum Curricular para a área de linguagens e o componente curricular Educação Física. Motrivivência, v. 28, n. 48, p. 32-41, setembro/2016.RUFINO, L. G. B; NETO, S. de S. Saberes docentes e formação de professores de Educação Física: análise da Base Nacional Comum Curricular (BNCC) na perspectiva da Profissionalização do Ensino. Motrivivência, v. 28, n. 48, p. 42-60, setembro/2016.SARAVÍ, J. R. A praxiologia motriz: presente, passado e futuro. Entrevista com Pierre Parlebas. Movimento, Porto Alegre, v. 18, n. 01, p. 11-35, jan/mar de 2012. Disponível em: http://seer.ufrgs.br/Movimento/article/view/27065 . Acesso em: Acesso em: 21/03/2018.SILVA, M. R; PIRES, G. L.; PEREIRA, R. S. A Base Nacional Comum Curricular da Educação Básica em tempos de neoconservadorismo e de “neoliberalismo que saiu do armário”; mas também de tempos de resistência: Fora Temer!!!. Motrivivência. Santa Cataria, v. 28, n. 48, 2016. Disponível em: https://periodicos.ufsc.br/index.php/motrivivencia/article/view/2175-8042.2016v28n48p7/32530 Acesso em: 09/08/2018. SHIROMA, E.O.; CAMPO, R. F.; GARCIA, R. M. C. Decifrar textos para compreender a política: subsídios teórico-metodológicos para análise de documentos. Perspectiva. Florianópolis, v. 23, n. 02, p. 427-446, jul./dez. 2005.TABORDA, D. S. Aproximações teóricas entre a praxiologia motriz e a proposta transformação didático-pedagógica do esporte: por um diálogo da possibilidade. Dissertação (Mestrado). UFSM. Programa de Pós-Graduação em Educação Física. RS, 2014. Disponível em: http://repositorio.ufsm.br/bitstream/handle/1/6744/TABORDA%2c%20DOUGLAS%20DOS%20SANTOS.pdf?sequence=1isAllowed=y . Acesso em: 20/03/2017.Recebido em 15-05-2018 e aceito em 14-08-2018.

Styles APA, Harvard, Vancouver, ISO, etc.

43

Thomas, Deborah A., Hagop M. Kantarjian, Jeffrey L. Jorgensen, Stefan Faderl, Elias Jabbour, William G. Wierda, Farhad Ravandi et al. « Outcomes for Adult Lymphoblastic Leukemia (ALL) Are Mainly Influenced by Age and Status of Minimal Residual Disease (MRD) by Multiparameter Flow Cytometry (MFC) After Therapy with the Modified Hyper-CVAD (with or without Rituximab) Regimen ». Blood 118, n^o 21 (18 novembre 2011) : 1524. http://dx.doi.org/10.1182/blood.v118.21.1524.1524.

Texte intégral

Résumé :

Abstract Abstract 1524 The hyper-CVAD regimen is an effective frontline program for de novo adult ALL [Kantarjian, JCO 18: 547, 2000; Kantarjian, Cancer 101: 2788, 2004]. Intensive cycles of hyper-CVAD (fractionated cyclophosphamide, vincristine [VCR], doxorubicin, dexamethasone) alternate with high dose methotrexate (MTX) and cytarabine every 21 days for 8 courses, followed by maintenance therapy with POMP (6-mercaptopurine, MTX, VCR, prednisone) interrupted by early and late intensifications. The regimen was modified in 1999 to include use of laminar air flow rooms during the induction phase for pts aged 60 years or older. Rituximab 375 mg/m2 (Days 1 & 11 of hyper-CVAD, Days 1 & 8 of MTX-cytarabine for 8 total doses) was administered for CD20 expression > 20% to counteract increased propensity for relapse [Thomas D, Blood 113: 6330, 2009]. Early anthracycline intensification with liposomal daunorubicin and cytarabine was incorporated from 1999–2000 then omitted from the regimen [Thomas D, Cancer 116: 4580, 2010]. CNS prophylaxis alternated intrathecal MTX day 2 with cytarabine day 7 of the first 3 courses for low CNS risk and first 4 courses for high CNS risk (in the absence of CNS disease). Maintenance therapy was extended from 24 to 30 months inclusive of early and late intensifications (hyper-CVAD followed by weekly MTX and L-asparaginase mos 6 & 7 then mos 18 & 19) to reduce incidence of late relapses. Results in the CD20 positive B-lymphoblastic subset treated with hyper-CVAD and rituximab were encouraging; 3-yr rates of CR duration (CRD) and survival (OS) were 60% and 50% overall, respectively. In younger (age < 60 years) CD20-positive subset, rates of CRD and OS were superior compared with standard hyper-CVAD (70% v 38%; P <.001% and 75% v 47%, P =.003) [Thomas D, JCO 28: 3830, 2010]. Historical experience in the adolescent and young adult (AYA) subset aged 15 – 30 yrs with CD20 positive B-lymphoblastic leukemia (now treated with pediatric augmented BFM regimen) showed that the addition of rituximab improved the 3-yr CRD rates from 26% to 65% (P =.001) and 3-yr OS rates from 47% to 75% (P =.05) compared with standard hyper-CVAD. There were no significant differences in outcome for the AYA subset by regimen (standard or modified) for the CD20 negative groups (all 3-yr rates > 70%). In contrast to the Burkitt leukemia experience, elderly pts with CD20 positive B-lymphoblastic leukemia treated with hyper-CVAD and rituximab did not benefit (rates of CRD 45% v 50%, P = NS and OS 28% v 32%, P = NS, respectively), related in part to deaths in CR. For the modified hyper-CVAD regimen (no anthracycline intensification), the rate of MRD negativity by 4- or 6-color MFC (sensitivity 0.01%, assay now 8-color MFC) at the time of CR in 95 evaluable pts was 72%. Overall, MRD positivity by MFC at the time of CR was associated with a higher relapse rate (52% v 21%, P =.01) and lower 3-yr CR duration rates (45% v 78%, P =.01). CD20 positive pts treated with rituximab had a higher rate of MRD negativity by MFC at CR than their CD20 negative counterparts (81% v 58%, P =.02). MRD positivity by MFC after hyper-CVAD and rituximab was associated with a significantly lower 3-yr CR duration rate (24% v 82%, P =.002), but survival rates were not statistically different (27% v 70%) likely due in part to deaths in CR in the older subset of the MRD-negative group. In contrast, for the CD20 negative subset, presence of detectable MRD by MFC at the time of CR did not influence 3-yr CR duration rate (58% v 63%). Additional doses of rituximab have been added to the consolidation cycles (Day 1 of cycles 5 – 8) and during the maintenance phase. Upfront dose reductions have been implemented for the induction-consolidation phase according to age and performance status in order to reduce deaths in CR. MTX-cytarabine cycles now include vincristine. All pts receive 8 IT treatments in the absence of CNS disease. Younger pts age 40 – 50 yrs receive pegylated asparginase (2000 Units/m2 with capping) during the induction-consolidation phase and early/late intensifications (augmented hyper-CVAD). Elderly pts or younger pts with B-lymphoblastic leukemia with contraindications to asparaginase are now treated with the hyper-CVAD and ofatumumab regimen regardless of CD20 expression. The cumulative experience of the serial modifications to the hyper-CVAD regimen stratified by age/MRD status and the preliminary experience with the frontline version of the augmented hyper-CVAD regimen will be presented. Disclosures: Off Label Use: Rituximab in Lymphoblastic Leukemia.

Styles APA, Harvard, Vancouver, ISO, etc.

44

SUASSUNA, Lívia, et Sabrina Leite FELIX. « SABERES EM MOVIMENTO NO ESTÁGIO DE REGÊNCIA DE TURMA : O ENSINO DE ANÁLISE LINGUÍSTICA POR GRADUANDOS DE LETRAS ». Trama 17, n^o 41 (1 juin 2021) : 09–27. http://dx.doi.org/10.48075/rt.v17i41.26732.

Texte intégral

Résumé :

Neste estudo pretendemos analisar o modo como alunos da licenciatura em Letras-Português da Universidade Federal de Pernambuco, durante o estágio curricular, atuam para ensinar seus alunos a refletir sobre a língua, concretizando um dos eixos de ensino desse componente curricular que é a análise linguística. A pesquisa, do tipo qualitativo-descritiva, teve como corpus projetos e relatórios de estágio, além de depoimentos dos estagiários, captados no seminário de encerramento das atividades de regência de turma do ensino fundamental. Para montar o referencial teórico, buscamos autores que tratam da formação docente, do estágio e do ensino de análise linguística. Os resultados mostraram que os futuros professores trabalham numa perspectiva sociointeracionista e exploram uma diversidade de gêneros textuais, como indicado nas orientações mais recentes para o ensino de língua portuguesa. No entanto, a maioria deles explicita pouco os procedimentos didáticos realizados, não indica as dificuldades dos alunos quando da avaliação da aprendizagem e aborda determinados conhecimentos linguísticos de forma expositiva e dedutiva.Referências:ALMEIDA FILHO, J. C. Crise, transições e mudança no currículo de formação de professores de línguas. In: FORTKAMP, M. B. M.; TOMITCH, L. M.B. (org.). Aspectos da linguística aplicada: estudos em homenagem ao professor Hilário Inácio Bohn. Florianópolis: Insular, 2000. p. 33-47.AZEVEDO, T. M. Ensinar gêneros? Desenredo, Passo Fundo, RS, v. 10, n. 1, p. 92-103 - jan./jun. 2014.AZEVEDO, T. M. Transposição didática de gêneros discursivos: algumas reflexões. Desenredo. Passo Fundo, RS, v. 6, n. 2, p. 198-214 - jul./dez. 2010.BARBOSA, J. Análise e reflexão sobre a língua e as linguagens: ferramentas para os letramentos. In: RANGEL, E. O.; ROJO, R. H. R. (org.) Língua Portuguesa no Ensino Fundamental. Coleção Explorando o Ensino. vol. 19. Brasília: MEC/SEB, 2010, p. 155-182.CALLIAN, G. R.; BOTELHO, L. S. A análise linguística e o ensino de língua portuguesa: em busca do desenvolvimento da competência discursiva. Educação em Destaque. Juiz de Fora, MG, v. 5, n. 1, p. 1-21, 2014.DICKEL, A. Ensino de gramática: das polêmicas às proposições. In: SEMINÁRIO NACIONAL SOBRE LINGUAGENS E ENSINO, 7, 2012, Pelotas. Anais... Pelotas: UCPel, 2012.DUTRA. C. M. D.; LOULA, L. D. Incompreensão e desalinhamento teórico-metodológico como possíveis entraves à prática de análise linguística em sala de aula. Domínios de Lingu@gem, Uberlândia, MG, vol. 11, n. 3, p. 526-547, jul./set. 2017.EMILIO, A. Gramática, deve-se ou não se deve ensinar? Línguas Letras. Cascavel, PR, v. 9. n. 16, p. 27-35. 2007.GERALDI, J. W. Concepções de linguagem e ensino de português. In: GERALDI, J. W. (org.). O texto na sala de aula. São Paulo: Ática, 1997[1984], p. 39-46.GERALDI, J. W. Unidades básicas do ensino de português. In: GERALDI, J. W. (org.). O texto na sala de aula: leitura e produção. Cascavel: Assoeste, 1984, p. 49-69.LARROSA, Jorge. Algunas notas sobre la experiencia y sus lenguajes. In: BARBOSA, R. L. L. (org.). Trajetórias e perspectivas da formação de educadores. São Paulo: Ed. Unesp, 2004. p.19-34.LOMBARDI, R. F. e ARBOLEA, T. A. Formando professores pesquisadores do ensino de língua materna. In: CONGRESSO LATINO-AMERICANO SOBRE FORMAÇÃO DE PROFESSORES DE LÍNGUA. 1, Florianópolis, Anais... 2006, p. 614-619.MENDONÇA, M. Análise linguística: por que e como avaliar. In: Marcuschi, B. SUASSUNA, L. (org.). Avaliação em língua portuguesa: contribuições para a prática pedagógica. Belo Horizonte: Autêntica, 2007, p. 95-110.NÓBREGA, J. J.; SUASSUNA, L. Aula de gramática ou de análise linguística? Investigando objetos de estudo e objetivos norteadores. Linguagens, Educação e Sociedade. Teresina, PI, n. 31, p. 246-269, jul. 2014.OLIVEIRA, M. B. F. Revisitando a formação de professores de língua materna: teoria, prática e construção de identidades. Linguagem em (Dis)curso. Tubarão, SC, v. 6, n. 1, p. 101-117, jan./abr. 2006.PETRONI, M. R.; JUSTINO, A. R.; MELO, E. S. O. Ainda sobre a formação do professor de língua portuguesa no Brasil. Interacções, Santarém, PT, n. 19, p. 28-37, 2011.PIMENTA, S. G.; LIMA, M. S. L. Estágio e docência: diferentes concepções. Poiésis. Tubarão, SC, vol. 3, números 3 e 4, p. 5-24, 2006.RAUBER, A. L. A formação do professor de Língua Portuguesa: o diálogo entre teoria e prática. In: MAGALHÃES, J. S.; TRAVAGLIA, L. C. (org.). Múltiplas perspectivas em linguística. Uberlândia/MG: EDUFU, 2008, v. 01, p. 346-356.REINALDO, M. A. G. M. O conceito de análise linguística como eixo de ensino de língua portuguesa no Brasil. Estudos Linguísticos, n. 8. Edições Colibri/CLUNL, Lisboa, p. 229-241, 2012.REMENCHE, M. L. R.; ROHLING, N. Análise linguística e formação de professores: um discurso sobre a dicotomia teoria e prática. In: SIMPÓSIO MUNDIAL DE ESTUDOS DE LÍNGUA PORTUGUESA. SIMELP. 5, 2017. Salento. Atas... Salento: Università del Salento, 2017.SILVA, N. I. Ensino tradicional de gramática ou prática de análise linguística: uma questão de (con)tradição nas aulas de português. Revista Brasileira de Linguística Aplicada. Belo Horizonte, MG, v. 10, n. 4, p. 949-973, 2010.SILVA, W. R.; FAJARDO-TURBIN, A. E. F. Relatório de estágio supervisionado como registro da reflexão pela escrita na profissionalização do professor. Polifonia, Cuiabá, MT, v. 18, n. 23, p. 103-128, jan./jun., 2011.SIQUEIRA, R. A. R.; MESSIAS, R. A. L. Reflexão e ações na formação e atuação do professor de língua portuguesa: o diálogo como condição de autoria na prática educativa. In: Linguagem Ensino, Pelotas, RS, v.11, n.2, p.377-392, jul./dez. 2008.SUASSUNA, L. Ensino de análise linguística: situando a discussão. In: SILVA, A.; PESSOA, A. C.; LIMA, A. (org.). Ensino de gramática: reflexões sobre a língua portuguesa na escola. Belo Horizonte, MG: Autêntica Editora, 2012, p. 11-28.TARDIF, M.; LESSARD, C.; LAHAYE, L. Os professores face ao saber: esboço de uma problemática do saber docente. Teoria e Educação, Porto Alegre, RS, v. 04, p. 215-233, 1991.VIEIRA, S. R. Prática de análise linguística sem ensino de gramática? Reflexões e propostas. In: ATAÍDE, C. et al. (org.). GELNE 40 anos. Experiências teóricas e práticas nas pesquisas em Linguística e Literatura. Paulo: Blucher, 2017, p. 299-318. Recebido em 05-01-2021Revisões requeridas em 28-04-2021Aceito em 12-05-2021

Styles APA, Harvard, Vancouver, ISO, etc.

45

Nja, Cecilia Obi, Kimson Joseph Idiege, Uduak Edet Uwe, Anne Ndidi Meremikwu, Esther Etop Ekon, Costly Manyo Erim, Julius Ukah Ukah, Eneyo Okon Eyo, Mary Ideba Anari et Bernedette Umalili Cornelius-Ukpepi. « Adoption of artificial intelligence in science teaching : From the vantage point of the African science teachers ». Smart Learning Environments 10, n^o 1 (15 septembre 2023). http://dx.doi.org/10.1186/s40561-023-00261-x.

Texte intégral

Résumé :

AbstractThis study investigated the factors influencing science teachers' 'Artificial Intelligence' (AI) utilization by using the 'Technology Acceptance Model' (TAM). The factors investigated alongside TAM variables were teachers' data like; age, sex, and residence type. TAM items that were correlated in this study included; self-esteem, stress and anxiousness, ease of utilization, behavioural intention, attitude towards AI usage, and expected benefits. The population of this study comprised all science teachers (170) in the Calabar Education Zone of Cross River State, Nigeria. The sample was made up of 79 science teachers comprising (58.22%) 46 females and (41.77%) 33 males. The descriptive and analytical research design was used in this study. A questionnaire named ' Approval of Artificial Intelligence: The Teachers' Eye' Questionnaire (AAITEQ) was used for the study. This study raised 3 research questions. The reliability for AAITEQ was from 0.72 to 0.81 using Cronbach's alpha. Findings indicated that the approval for the utilization of AI was high with an overall mean score of 3.00. The highest predicting value for behaviour intent using TAM variables was the ease of usage r = .789. Science teachers' sex (t, 77 = 1.988; p = .060, (p ˃ .05), age F (2, 76) = .547; p = .581 (p ˃ .05) and teachers' residence location (t, .77 = .533; p = − .062 (p ˃ .05) did not influence the behaviour of science teachers' intention of the utilization of AI. It was recommended that both in-service and pre-service teachers be trained on the utilization of AI.

Styles APA, Harvard, Vancouver, ISO, etc.

46

Sun, Guang-Yi, Hao Jing, Shu-Lian Wang, Yong-Wen Song, Jing Jin, Hui Fang, Yue-Ping Liu et al. « Trastuzumab Provides a Comparable Prognosis in Patients With HER2-Positive Breast Cancer to Those With HER2-Negative Breast Cancer : Post Hoc Analyses of a Randomized Controlled Trial of Post-Mastectomy Hypofractionated Radiotherapy ». Frontiers in Oncology 10 (26 janvier 2021). http://dx.doi.org/10.3389/fonc.2020.605750.

Texte intégral

Résumé :

Background and PurposeWe investigated the locoregional effect of trastuzumab, and determined whether patients with human epidermal growth factor receptor (HER)2-positive breast cancer (BC) treated with trastuzumab could achieve comparable efficacy to that of patients with HER2-negative BC.Materials and MethodsThis was post hoc analyses of data of 793 BC patients from a randomized controlled trial comparing post-mastectomy hypofractionated radiotherapy with conventional fractionated radiotherapy. Survival rates were analyzed by the Kaplan–Meier method and compared by the log-rank test.ResultsPatients were classified into three groups: HER2-negative (HER2−; n = 547), HER2-positve with trastuzumab (HER2+ + T; n = 136), and HER2-positive without trastuzumab (HER2+ − T; n = 110). The HER2+ + T group had significantly lower locoregional recurrence (LRR, 6.0% vs. 13.9%), distant metastasis (DM, 17.4% vs. 33.8%) and higher disease-free survival (DFS, 81.2% vs. 61.9%) at 5 years than that of the HER2+ − T group (P <.05). The HER2− group had significantly lower LRR (6.8% vs. 13.9%), DM (22.4% vs. 33.8%) and higher DFS (76.1% vs. 61.9%) at 5 years than that of the HER2+ − T group (P <.05). The difference in LRR, DM and DFS at 5 years was not significant between the HER2+ + T group and HER2− group (P >.05). Different annual LRR patterns was found among groups according to HR status.ConclusionTrastuzumab reduces LRR in patients with locally advanced HER2-positive BC who have received post-mastectomy radiotherapy. It provides comparable DFS to that with patients with HER2-negative BC.

Styles APA, Harvard, Vancouver, ISO, etc.

47

KOÇALİ, Kaan. « Madencilik sektörü iş kazalarının kayıp iş günü ve cinsiyet risk faktörleri açısından sürveyans analizi ». Bilimsel Madencilik Dergisi, 5 juillet 2022. http://dx.doi.org/10.30797/madencilik.1081296.

Texte intégral

Résumé :

Bu çalışmada Türkiye madencilik sektörünü oluşturan “05 - Kömür ve Linyit Çıkartılması”, “07 - Metal Cevheri Madenciliği”, “08 - Diğer Madencilik ve Taşocakçılığı” ve “09 - Madenciliği Destekleyici Hizmetler” kodlu işletmelerde meydana gelen iş kazalarının kayıp iş günü ve cinsiyet risk faktörleri göz önünde bulundurularak sürveyans analizi yapılmıştır. Çalışma kapsamında, Amerika Birleşik Devleti Ulusal Standartlar Enstitüsü (ANSI) tarafından madencilik sektöründe kullanılan Z16.1-1967 isimli standart kapsamında yapılan çalışmalar ülkemize uyarlanmıştır. 2012-2020 yılları arasında Sosyal Sigortalar Kurumu (SGK)’na kayıtlı toplam 60.852 işyerinde toplam 1.210.926 adet sigortalı işçi çalıştırılarak, yaşanan iş kazalarında 11.214’sini erkek, 547’sinin ise kadın çalışanın etkilendiği görülmüştür. Kaza geçiren sigortalı erkek çalışanların toplam 1.496.268 gün, sigortalı kadın çalışanların ise 5.959 gün iş görmezlik süresi geçirdiği bulunmuştur. Bir kadın sigortalı iş kazasına karşılık 205 adet erkek sigortalı iş kazası meydana geldiği ve erkek sigortalıların iş kazası geçirdiklerinde kadın sigortalılara oranla ortalama 268,72 günlük iş kaybına uğradıklarını hesaplanmıştır. İş kazasının ve kayıp iş gücünün en çok yaşandığı alt sektörler yıllık olarak tek tek analiz edilerek ortaya çıkan sonuçlar ile iş kazalarının önlenmesinde alınabilecek olan önlemler önerilmiştir.

Styles APA, Harvard, Vancouver, ISO, etc.

48

Wands, David I. F., Laura Gianolio, David C. Wilson, Richard Hansen, Iain Chalmers, Paul Henderson, Konstantinos Gerasimidis et Richard K. Russell. « Nationwide Real-World Exclusive Enteral Nutrition Practice Over Time : Persistence of Use as Induction for Pediatric Crohn’s Disease and Emerging Combination Strategy With Biologics ». Inflammatory Bowel Diseases, 24 août 2023. http://dx.doi.org/10.1093/ibd/izad167.

Texte intégral

Résumé :

Abstract Background Exclusive enteral nutrition (EEN) is the recommended first-line induction treatment in pediatric patients with active luminal Crohn’s disease (CD). We aimed to provide a nationwide overview of evolving EEN practices during an era of increasing biologic use. Methods We analyzed a prospectively identified nationwide cohort of newly diagnosed pediatric patients with CD in Scotland between January 1, 2015, and June 30, 2022. Patients who received EEN for any indication were divided into 6-monthly epochs and examined over time. Differences during the COVID-19 pandemic (March 16, 2020, to July 19, 2021) were examined. Data were retrospectively collected from electronic medical records: demographics, anthropometrics, concomitant treatments, aspects of EEN administration, and remission/response rates. Descriptive statistics and linear regression were used for analyses. Results A total of 649 patients with CD were identified (63% male; median age 12.6 [interquartile range, 10.8-14.8] years); 497 (77%) of 649 received EEN as postdiagnosis induction therapy with a median course length of 7.7 (interquartile range, 5.9-8.0) weeks. Including repeat courses, 547 EEN courses were examined. An increasing incidence of CD was observed over time with no significant changes in EEN usage, remission or response rates, nasogastric tube usage, or course completion (all P > .05). Increasing use of EEN combined with biologics (combination induction) as first-line induction was observed over time (P < .001). Considering COVID-19, lower rates of EEN usage were observed (P = .008) with no differences in remission, oral administration, and course completion rates (all P > .05). Conclusions Over the past 7.5 years, except during the COVID-19 pandemic, EEN usage rates have not changed despite an increase in biologic use, although combination induction is an emerging trend.

Styles APA, Harvard, Vancouver, ISO, etc.

49

Higueras-Serrano, I., M. Cerván-Martín, S. González Muñoz, A. Guzmán-Jiménez, J. A. Castilla, N. Garrido, S. Luján et al. « P-055 Influence of a dynamic exposome on the genetic component of male infertility ». Human Reproduction 39, Supplement_1 (1 juillet 2024). http://dx.doi.org/10.1093/humrep/deae108.432.

Texte intégral

Résumé :

Abstract Study question Do the genetic factors associated with idiopathic severe spermatogenic failure (SPGF) differ across age groups due to evolving environmental exposures over generations? Summary answer Dynamic changes in environmental exposures have the potential to reshape the genetic predisposition to idiopathic SPGF. What is known already Accumulating evidence suggests that the idiopathic form of SPGF may represent a complex trait with a multifactorial aetiology, wherein environmental factors influence the predisposition and development of the disease through their interaction with genetic polymorphisms. In a recent genome-wide association study (GWAS) of SPGF conducted in a European population, we identified genetic variants associated with this condition in immune and spermatogenesis-related genes. However, while GWASs serve as valuable tools for identifying susceptibility risk loci, our understanding of the influence of environmental factors and their specific impact on the genetic architecture of these conditions remains limited. Study design, size, duration Genome-wide genotype data from 912 SPGF cases and 1,360 unaffected controls from the Iberian Peninsula and Germany were analysed considering age as a proxy to assess exposure to varying environmental factors across generations. An in silico functional prioritisation of associated genomic regions was also performed to comprehensively evaluate the gene-environment relationships influencing the disease. Participants/materials, setting, methods The study cohort was stratified into two age groups: individuals aged 40 or older in 2023 (452 cases and 965 controls) and those under 40 in 2023 (460 cases and 424 controls). SPGF comprised individuals with non-obstructive azoospermia (n = 547) or non-obstructive oligozoospermia (n = 365). Logistic regression models were used for the case-control analysis, with the generation included as a covariate. Bioinformatic approaches involved the examination of functional annotations of the genome sourced from different public databases. Main results and the role of chance Thirteen genetic loci were found to be associated with idiopathic SPGF, assuming generation-dependent effects. Five of them showed a correlation with an increased susceptibility to SPGF in the youngest age group (rs72818509: P = 2.19E−05, rs57701320: P = 5.20E−05, rs79733930: P = 7.81E−05, rs77137582: P = 1.04E−04, rs75938373: P = 3.56E−05), while the remaining eight were specifically associated with the disease in the oldest age group (rs144324356: P = 2.37E−05, rs3763812: P = 8.61E−05, rs61997636: P = 1.00E−04, rs111364930: P = 9.63E−05, rs115408081: P = 5.77E-05, rs142908940: P = 1.76E−04, rs144031067: P = 1.76E-04, rs74514513: P = 1.76E-04). These associations were primarily attributed to the interaction between each lead variant and the age group. Additionally, associations were established between the identified genomic risk loci and various environmental factors, including toxic habits (such as smoking or alcohol consumption), diet-related traits (such as cholesterol levels, type 2 diabetes, and body mass index), respiratory disorders (such as asthma or COVID-19), autoimmune diseases (including systemic lupus erythematosus), and educational attainment. Our findings suggest that changes in environmental factors across generations could alter the genetic basis of idiopathic SPGF over time. Limitations, reasons for caution Despite the overall statistical power of our study cohort being suitable for detecting the expected effects, further independent studies comprising extensive cohorts across diverse ethnic populations are needed to validate the outcomes of our research. Wider implications of the findings Using a novel approach assess the potential impact of varying environmental factors on the genetic susceptibility to complex diseases, we gained insights into the intricate mechanisms underlying onset and progression of idiopathic SPGF. Understanding the etiological causes of multifactorial human disorders would help in developing personalized healthcare strategies. Trial registration number Not applicable

Styles APA, Harvard, Vancouver, ISO, etc.

50

Stefana, Alberto, et Eric A. Youngstrom. « Erotic Feelings Towards Patients in the Psychotherapy Session : Investigating Their Relationship With the Characteristics of the Therapist, the Patient, and the Treatment ». Sexual Abuse, 17 juillet 2023. http://dx.doi.org/10.1177/10790632231190081.

Texte intégral

Résumé :

Experiencing erotic feelings towards a patient is a fairly common occurrence, not pathological per se, during phases of psychotherapy. This study aims to analyze associations between, on the one hand, the presence in therapists of romantic attraction (RA), sexual attraction (SA), or flirting behavior (FB) toward patients and, on the other hand, a series of characteristics of therapist, patient, and treatment. Between April and June 2022, 547 psychotherapists completed an online survey investigating their affective and behavioral responses toward their most recently treated patient. Compared to female therapists, males showed significantly higher prevalence of SA alone ( p < .001) or in combination with RA ( p < .01), FB ( p < .01), or both ( p < .05). Multivariate adjusted regression models showed that RA was associated with patient age ≤40 years (OR:39.49 for age 18–29; OR:28.44 for age 30–39), male sex (OR:10.40), and diagnosis of mood disorder (OR:14.08). Furthermore, RA was associated with intense countertransference feelings of tenderness towards the patient (OR:79.77) and hostility towards significant figures in their life (OR: 77.93). SA was associated with the therapist’s male sex/gender (OR: 16.14), psychoanalytic orientation (OR:13.34), post-license experience ≤20 years (OR:6.12 for 1–9 years; OR:6.08 for 10–19 years). Lastly, FB was associated with the therapist’s male sex/gender (OR:16.94).

Styles APA, Harvard, Vancouver, ISO, etc.

Articles de revues sur le sujet « 547/.05 »

Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres