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Littérature scientifique sur le sujet « 4-oxadiazoly »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 1 février 2022

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Articles de revues sur le sujet "4-oxadiazoly"

Stepanova, Elena V., et Andrei I. Stepanov. « UNUSUAL WAY OF REACTION OF 3-AMINO-4-(5-CHLOROMETHYL-1,2,4-OXADIAZOLE-3-YL)-FURAZAN WITH HYDRAZINE ». IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, n^o 4 (12 mai 2017) : 26. http://dx.doi.org/10.6060/tcct.2017604.5522.

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The results of our study of the pathways of selective reactivity of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan versus 5-unsubstituted or 5-methyl and 5-trifluoromethyl substituted 4-(5R-1,2,4-oxadiazole-3-yl)furazans (R = H, Me, CF3) towards the action of hydrazine are discussed. If the reductive opening of 1,2,4-oxadiazole ring in unsubstituted at the С-5 atom (1,2,4-oxadiazol-3-yl)furazan derivatives under the treatment with hydrazine can be used as a method for the preparation of a range of amidrazones of 4-R-furazan-3-carboxylic acid. 3-amino-4-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)furazan with hydrazine gives amidoxime of 4-aminofurazan-3-carboxylic acid. 3-amino-4-(5-methyl-1,2,4-oxadiazol-3-yl) furazan is inert to the action of hydrazine, on the contrary the reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine leads to oxidation of chloromethyl group of titled compound to the carbonyl one. In this case the product of reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine was isolated in a form of corresponding hydrazonomethyl derivative notably as 3-amino-4-(5-hydrazonomethyl-1,2,4-oxadiazole-3-yl)furazan. A possible reaction mechanism for the formation of hydrazonomethyl group by oxidation reaction of chloromethyl group by hydrazine is proposed. 3-Amino-4-(5-hydrazonomethyl-1,2,4-oxadiazol-3-yl)furazan undergoes a transhydrazination reaction with semicarbazide and thiosemicarbazide. But our attempts to its hydrolysis for the purpose to obtain free aldehyde were unsuccessful. Thus, hydrolysis of hydrazonomethyl derivative in acetic acid in the presence of catalytic amount of sulfuric acid results in azine – N,N'-bis(3-(4-aminofurazan-3-yl)-1,2,4-oxadiazol-5-ylmethylyden)hydrazine – precipitation, long-duration boiling in hydrochloric acid leads to Kishner-Wolff reduction of the carbonyl group to 3-amino-4-(5-methyl-1,2,4-oxadiazol-3-yl)furazan, and hydrolysis in alkaline medium leads to 1,2,4-oxadiazole ring opening to amidoxime of 4-aminofurazan-3-carboxylic acid. Synthesis of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan (R = CH2Cl) was carried out by condensation of amidoxime of 4-aminofurazan-3-carboxylic acid with an excess of chloroacetyl chloride in toluene at elevated temperature. The reaction proceeds through formation of intermediate product – 3-chloromethylamino-4-(5-chloromethyl-1,2,4-oxadiazol-3-yl)furazan. Removing of N-chloroacetyl group in such obtained intermediate was performed by hydrolysis in acidic media. One-pot synthesis without the need for isolation and purification of intermediate is allowed. The structures of obtained compounds were proved by modern methods of physical-chemical analysis (1H, 13C NMR, IR and MS spectroscopy).Forcitation:Stepanova E.V., Stepanov A.I. Unusual way of reaction of 3-amino-4-(5-chloromethyl-1,2,4-oxadiazole-3-yl)furazan with hydrazine. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 4. P. 26-32.

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Ahsan, Mohamed Jawed, Arun Choupra, Rakesh Kumar Sharma, Surender Singh Jadav, Pannala Padmaja, Mohd Zaheen Hassan, Abdulmalik Bin Saleh Al-Tamimi, Mohammed H. Geesi et Mohammed Afroz Bakht. « Rationale Design, Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of 1,3,4-oxadiazole Analogues ». Anti-Cancer Agents in Medicinal Chemistry 18, n^o 1 (16 mars 2018) : 121–38. http://dx.doi.org/10.2174/1871520617666170419124702.

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Background: 1,3,4-Oxadiazole heterocycles possess a broad spectrum of biological activities. They were reported as potent cytotoxic agents and tubulin inhibitors; hence it is of great interest to explore new oxadiazoles as cytotoxic agents targeting tubulin polymerization. Objective: Two new series of oxadiazoles (5a-h and 12a-h) were synthesized, structurally related to the heterocyclic linked aryl core of IMC-038525, NSC 776715, and NSC 776716, with further modification by incorporating methylene linker. Method: The 2,5-disubstituted-1,3,4-oxadiazoles (5a-h and 12a-h) were synthesized by refluxing an equimolar mixture of the intermediates [(4) and (8a-d)] and aromatic aldehydes in water-ethanol system using sodium bisulphite catalyst. The cytotoxicity evaluation was carried out according to the National Cancer Institute (NCI US) Protocol, while the tubulin polymerization assay kits from Cytoskeleton ™(bk011p) was used to perform an in vitro tubulin polymerization assay. Results: 2-(5-{[(4-Chlorophenyl)amino]methyl}-1,3,4-oxadiazol-2-yl)phenol (5f) and 2-[(2,4-dichlorophenoxy) methyl]-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole (12c) showed maximum cytotoxicity with the mean percent growth inhibitions (GIs) of 71.56 and 72.68 respectively at 10 µM drug concentrations. Both the compounds (5f and 12c) showed superior cytotoxicity than clinically prevalent anticancer drugs, Imatinib and Gefitinib in one dose assay. The compound 12c showed promising results in five dose assay, with GI50 values varies between 1.61 and >100 µM. Furthermore, the compounds, 5f and 12c also inhibited the polymerization of tubulin with, an IC50 of 2.8 and 2.2 µM, respectively. Conclusion: The oxadiazoles reported herein are tubulin inhibitors and cytotoxic agents. These findings will be helpful in future drug design of more potent tubulin inhibitor cytotoxic agents.

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Mohammadi-Khanaposhtani, Maryam, Kiana Fahimi, Elahe Karimpour-Razkenari, Maliheh Safavi, Mohammad Mahdavi, Mina Saeedi et Tahmineh Akbarzadeh. « Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents ». Letters in Drug Design & ; Discovery 16, n^o 7 (27 juin 2019) : 818–24. http://dx.doi.org/10.2174/1570180815666180627121006.

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Background: This work reports design, synthesis, and in vitro cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids against three breast cancer cell lines MCF-7, MDA-MB-231, and T-47D. Methods: Synthetic procedure for the preparation of desired compounds was started from the reaction of coumarins or with propargyl bromide to give O-propargylated coumarins or 5. Then, click reaction between the later compounds and 3-aryl-5-(chloromethyl)-1,2,4-oxadiazoles afforded the desired products in good yields. Results: Among the synthesized compounds, 4-((1-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5- yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)-2H-chromen-2-one (9a) showed the best cytotoxicity against breast cancer cell lines. Conclusion: Compound 9a depicted the most activity toward MDA-MB-231 and T-47D cells while compounds 8a and 8c were the most potent compounds against MCF-7.

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Saini, Sachin. « Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety ». Drug Research 69, n^o 08 (20 décembre 2018) : 445–50. http://dx.doi.org/10.1055/a-0809-5098.

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Abstract2-Amino-5-(3’-indolomethylene)-1, 3 , 4 - oxadiazole (3) undergoes facile condensation with various aromatic aldehydes to gave 2-substitiuted arylidenylamino-5-(3’- indolomethylene) – 1, 3 , 4 – oxadiazole (4–8). Cyclocondensation of (4–8) with thioglycolic acid and triethylamine yielded 3-[5’-(3”- indolomethylene)- 1’, 3’, 4’- oxadiazol-2’-yl]- 2- (substituted aryl)-4- thiazolidinones (9–13) and 1-[5’-(3”- indolomethylene) -1’, 3’, 4’- oxadiazol - 2’- yl ] -4-(substituted aryl) -2- azetidinones (14–18). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesised compounds were evaluated for their anticonvulsant activity and acute toxicity.

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Godovikova, T. I., S. K. Vorontsova, L. D. Konyushkin, S. I. Firgang et O. A. Rakitin. « 4-Methyl-1,2,5-oxadiazole-3-carbonitrile in the synthesis of 1,2,5-oxadiazolyl-1,2,4-oxadiazoles ». Russian Chemical Bulletin 57, n^o 11 (novembre 2008) : 2440–42. http://dx.doi.org/10.1007/s11172-008-0349-4.

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Tang, Yongxing, Chunlin He, Lauren A. Mitchell, Damon A. Parrish et Jean'ne M. Shreeve. « Energetic compounds consisting of 1,2,5- and 1,3,4-oxadiazole rings ». Journal of Materials Chemistry A 3, n^o 46 (2015) : 23143–48. http://dx.doi.org/10.1039/c5ta06898c.

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3-Nitroamino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan monohydrate (2·H₂O), which is a combination of the nitroaminofurazan and 1,3,4-oxadiazole rings, was obtained by the nitration of 3-amino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan (1) with 100% nitric acid.

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Ahsan, Mohamed Jawed, Mohd Zaheen Hassan, Surender Singh Jadav, Mohammed H. Geesi, Mohammed Afroz Bakht, Yassine Riadi, Salahuddin, Md Sayeed Akhtar, Mohammad Nasar Mallick et Md Habban Akhter. « Synthesis and Biological Potentials of 5-aryl-N-[4-(trifluoromethyl) phenyl]-1,3,4-oxadiazol-2-amines ». Letters in Organic Chemistry 17, n^o 2 (7 janvier 2020) : 133–40. http://dx.doi.org/10.2174/1570178616666190401193928.

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Oxadiazoles are an important class of heterocyclic compounds, having broad-spectrum activity. They were also reported as anticancer, and antioxidant agents, hence it is of significant importance to explore new oxadiazoles. A series of eleven (5-aryl-N-[4-(trifluoromethyl)phenyl]-1,3,4- oxadiazol-2-amines (6a-k) was synthesized based on the structures of reported compounds, SU-101, IMC38525, and FTAB. All these oxadiazoles were synthesized, characterized by spectral data, and further tested against melanoma, leukemia, colon, lung, CNS, ovarian, renal, breast and prostate cancer cell lines’ panels at a single dose of 10 μM drug concentrations. N-(4-(Trifluoromethyl)phenyl)-5-(3,4- dimethoxyphenyl)-1,3,4-oxadiazol-2-amine (6h) showed significant anticancer activity, and the most sensitive five cell lines were NCI-H522 (% GI = 53.24), K-562 (% GI = 47.22), MOLT-4 (% GI = 43.87), LOX-IMVI (% GI = 43.62), and HL-60(TB) (% GI = 40.30). The compound, 6h revealed better %GIs than imatinib, against 36 cell lines, taking 54 cell lines in common. The maximum sensitivity was recorded against cancer cell line CCRF-CEM (% GI = 68.89) by 2-(5-(4-(trifluoromethyl) phenylamino)-1,3,4-oxadiazol-2-yl)phenol (6f). The antioxidant activity of 4-(5-(4-(trifluoromethyl) phenylamino)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol (6i) was promising with an IC50 of 15.14 μM. It was observed that the oxadiazoles reported herein showed significant anticancer and antioxidant activities.

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Yadav, Mange, Shrikant Shirude, Devendra Puntambekar, Pinkal Patel, Hetal Prajapati, Arvind Parmar, R. Balaraman et Rajani Giridhar. « Studies in 3,4-diaryl-1,2,5-oxadiazoles and their N-oxides : Search for better COX-2 inhibitors ». Acta Pharmaceutica 57, n^o 1 (1 mars 2007) : 13–30. http://dx.doi.org/10.2478/v10007-007-0002-z.

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Studies in 3,4-diaryl-1,2,5-oxadiazoles and theirN-oxides: Search for better COX-2 inhibitorsA series of 3,4-diaryl-1,2,5-oxadiazoles and 3,4-diaryl-1,2,5-oxadiazoleN-oxides were prepared and evaluated for COX-2 and COX-1 binding affinityin vitroand for anti-inflammatory activity by the rat paw edema method.p-Methoxy (p-OMe) substituted compounds 9, 21, 34, 41, 42 showed COX-2 enzyme inhibition higher than that showed by compounds with other substituents. 3,4-Di(4-methoxyphenyl)-1,2,5-oxadiazoleN-oxide (42) showed COX-2 enzyme inhibition of 54% at 22 μmol L-1and COX-1 enzyme inhibition of 44% at 88 μmol L-1concentrations, but showed very lowin vivoanti-inflammatory activity. Its deoxygenated derivative (21) showed lower COX-2 enzyme inhibition (26% at 22 μmol L-1) and higher COX-1 enzyme inhibition (53% at 88 μmol L-1) but, markedin vivoanti-inflammatory activity (71% at 25 mg kg-1)vs.celecoxib (48% at 12.5 mg kg-1). Molecular modeling (docking) studies showed that the methoxy group is positioned in the vicinity of COX-2 secondary pocket and it also participates in hydrogen bonding interactions in the COX-2 active site. These preliminary studies suggest thatp-methoxy (p-OMe) group in one of benzene rings may give potentially active leads in this series of oxadiazole/N-oxides.

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Jin, Guoxia, Yuqi Ji, Teng Wang, Yanyan Sun, Yulong Li, Guiying Zhu et Jianping Ma. « Syntheses and characterization of dinuclear and tetranuclear AgI supramolecular complexes generated from symmetric and asymmetric molecular clips containing oxadiazole rings ». Acta Crystallographica Section C Structural Chemistry 75, n^o 10 (6 septembre 2019) : 1327–35. http://dx.doi.org/10.1107/s2053229619011744.

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A new asymmetric ligand, 5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole (L5), which contains two oxadiazole rings, was synthesized and characterized. The assembly of symmetric 2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole (L1) and asymmetric L5 with AgCO2CF3 in solution yielded two novel AgI complexes, namely catena-poly[[di-μ-trifluoroacetato-disilver(I)]-bis[μ-2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole]], [Ag2(C2F3O2)2(C12H8N4O)2] n or [Ag2(μ2-O2CCF3)2(L1)2] n (1), and bis(μ3-5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole)tetra-μ3-trifluoroacetato-tetrasilver(I) dichloromethane monosolvate, [Ag4(C2F3O2)4(C22H15N5O2)2]·CH2Cl2 or [Ag2(μ3-O2CCF3)2(L5)]2·CH2Cl2 (2). Complex 1 displays a one-dimensional ring–chain motif, where dinuclear Ag2(CF3CO2)2 units alternate with Ag2(L1)2 macrocycles. This structure is different from previously reported Ag–L1 complexes with different anions. Complex 2 features a tetranuclear supramolecular macrocycle, in which each ligand adopts a tridentate coordination mode with the oxadiazole ring next to the p-tolyl ring coordinated and that next to the pyridyl ring free. Two L5 ligands are bound to two Ag1 centres through two oxadiazole N and two pyridyl N atoms to form a macrocycle. The other two oxadiazole N atoms coordinate to the two Ag2 centres of the Ag2(O2CCF3)4 dimer. Each CF3CO2 − anion adopts a μ3-coordination mode, bridging the Ag1 and Ag2 centres to form a tetranuclear silver(I) complex. This study indicates that the donor ability of the bridging oxadiazole rings can be tuned by electron-withdrawing and -donating substituents. The emission properties of ligands L1 and L5 and complexes 1 and 2 were also investigated in the solid state.

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Yurttaş, Leyla, Betül K. Çavuşoğlu, Gülşen A. Çiftçi et Halide E. Temel. « Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors ». Anti-Cancer Agents in Medicinal Chemistry 18, n^o 6 (12 novembre 2018) : 914–21. http://dx.doi.org/10.2174/1871520618666180322123327.

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Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized and evaluated for determining their anticancer, anticholinesterase and lipoxygenase (LOX) inhibitory activity. Methods: All compounds were tested against C6 rat glioma, A549 human lung carcinoma and NIH/3T3 mouse embryo fibroblast cell lines to define cytotoxic concentrations and apoptosis induction levels which they cause. Results: Many of the compounds exhibited remarkable potency that compounds 2a, 2b, 2e, 2h and 2j against C6 cells and compounds 2a, 2b, 2d, 2g, 2i, 2j against A549 cells were found more active than cisplatin. Compound 2d namely, 2-[(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl)thio]-1-(4-chlorophenyl)ethan-1-one induced apoptosis of A549 cells with 74.9% whereas cisplatin caused 70.9% percentage. Conclusion: Among them, compounds 2d and 2j against A549 cell line, compounds 2b and 2e against both tumor cell lines showed selective cytotoxicity evaluating the inhibition concentration against NIH/3T3 cell line. None of the compounds showed significant acetylcholinesterase (AChE) and lipoxygenase inhibitory activities.

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Thèses sur le sujet "4-oxadiazoly"

Kivrak, Arif. « Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles ». Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.

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Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In the first part of the study, electrophilic cyclization of &alpha
,&beta
-alkynic hydrazones by molecular iodine and copper iodide were investigated as new ways for the synthesis of 4-iodopyrazoles and pyrazoles, respectively. Initially, &alpha
,&beta
-alkynic hydrazones were prepared by the reactions of propargyl aldehydes and ketones with hydrazines. Then &alpha
,&beta
-alkynic hydrazones were treated with molecular iodine in the presence of NaHCO3, which afforded 4-iodopyrazoles in good to excellent yields. Subsequently, the same reactions were carried out with CuI in the presence of NEt3, which furnished corresponding pyrazoles in good yields. Moreover, ferrocenyl-substituted 4-iodopyrazoles and pyrazole derivatives were synthesized from corresponding

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Paulo, TÃrcio de Freitas. « 5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O : SÃntese, caracterizaÃÃo e estudos de formaÃÃo de monocamadas automontadas ». Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1418.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
As espÃcies 5-(4-piridil)-1,3,4-oxadiazol-2-tiol (Hpyt) e [Fe(CN)5Hpyt]3- (FeHpyt) adsorvem espontaneamente sobre ouro formando monocamadas automontadas (SAM - "Self-Assembled Monolayers") das quais, de acordo com os dados eletroquÃmicos, apresentam defeitos ou nanoporos por onde as molÃculas de prova [Fe(CN)6]4â e [Ru(NH3)6]3+ acessam a superfÃcie do eletrodo de ouro policristalino. A partir dessas molÃculas de prova e da dependÃncia entre a corrente faradÃica e o pH do eletrÃlito, o pKa da monocamada de Hpyt foi calculada como 4,2. A partir dos resultados de microscopia de tunelamento STM (Scanning Tunneling Microscopy) obtidos para a monocamada automontada de Hpyt sobre Au(111) foi possÃvel estimar que as molÃculas de Hpyt sÃo adsorvidas em um arranjo hexagonal com um espaÃamento mÃdio entre os Ãtomo de enxofre de 5,5 Ã. Essas imagens tambÃm mostraram a presenÃa de nanoporos, do qual indica que fortes interaÃÃes laterais nÃo ocorrem efetivamente. Os parÃmetros termodinÃmicos ΔHads, ΔGads e ΔSads para o processo de adsorÃÃo das molÃculas Hpyt e FeHpyt foram calculados a partir da correlaÃÃo entre a concentraÃÃo dos adsorbatos na superfÃcie (Γ) e em soluÃÃo (C) para diferentes temperaturas. A quantidade de molÃculas adsorvidas foi calculada a partir do processo de desorÃÃo redutiva, onde R = Hpyt ou FeHpyt, observados em -555 e -566 mV versus Ag|AgCl|Cl- para as monocamadas de Hpyt e FeHpyt, respectivamente, indicando um fortalecimento da ligaÃÃo AuâS como conseqÃÃncia do efeito π-backbonding do centro metÃlico ferro para o ligante Hpyt. A reaÃÃo heterogÃnea de transferÃncia de elÃtrons da metaloproteÃna citocromo c foi satisfatoriamente acessada pelas monocamadas de Hpyt e FeHpyt, apresentando um voltamograma quasi-reversÃvel com potenciais consistentes com a forma nativa desta proteÃna.
-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) and [Fe(CN)5Hpyt]3- (FeHpyt) species spontaneously adsorbed on gold forming SAM (Self-Assembled Monolayers) that, based on electrochemical data, contain pinholes through which [Fe(CN)6]4â and [Ru(NH3)6]3+ probe molecules access the underlying gold electrode. From the former molecule and the dependence of the faradaic current on the pH value of the electrolyte solution, the surface pKa of the Hpyt SAM was evaluated as 4.2. Taking into account the STM (Scanning tunneling Microscopy) results obtained for the Hpyt SAM on Au(111), it was possible to estimate that the Hpyt molecules are adsorbed in an hexagonal arrangement with an average distance between the sulfur atoms of 5.5 Ã. These images also showed the presence of pinholes, which indicate that a strong lateral interaction does not effectively happen. The thermodynamics parameters ΔHads, ΔGads and ΔSads of the Hpyt and FeHpyt adsorption process were calculated from the correlation between the concentration of the adsorbates on the surface (Γ) and in solution (C) at different temperatures. The surface coverage data were obtained from the reductive desorption process RS-Au + e- �� RS- + AuÂ, where R = Hpyt or FeHpyt, observed at -555 and -566 mV vs Ag|AgCl|Cl- for Hpyt and FeHpyt SAM, respectively, indicating an enhancement of the AuâS bond as consequence of the π-backbonding interaction from iron metal center toward the Hpyt moiety. The heterogeneous electron transfer reaction of cytochrome c metalloprotein was successfully assessed by Hpyt and FeHpyt and SAM, presenting a quasi-reversible voltammograms with potentials consistent with the native form of the protein.

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Paulo, Tércio de Freitas. « 5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O : Síntese, caracterização e estudos de formação de monocamadas automontadas ». reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/13715.

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PAULO, T. F.; DIÓGENES, I. C. N. 5-(4-PIRIDIL)-1,3,4-(OXADIAZOL)-2-TIOL E Na3[Fe(CN)5Hpyt].3H2O: Síntese, caracterização e estudos de formação de monocamadas automontadas. 2007. 85 f. Dissertação (Mestrado em Química Inorgânica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2007.
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-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol (Hpyt) and [Fe(CN)5Hpyt]3- (FeHpyt) species spontaneously adsorbed on gold forming SAM (Self-Assembled Monolayers) that, based on electrochemical data, contain pinholes through which [Fe(CN)6]4– and [Ru(NH3)6]3+ probe molecules access the underlying gold electrode. From the former molecule and the dependence of the faradaic current on the pH value of the electrolyte solution, the surface pKa of the Hpyt SAM was evaluated as 4.2. Taking into account the STM (Scanning tunneling Microscopy) results obtained for the Hpyt SAM on Au(111), it was possible to estimate that the Hpyt molecules are adsorbed in an hexagonal arrangement with an average distance between the sulfur atoms of 5.5 Å. These images also showed the presence of pinholes, which indicate that a strong lateral interaction does not effectively happen. The thermodynamics parameters ΔHads, ΔGads and ΔSads of the Hpyt and FeHpyt adsorption process were calculated from the correlation between the concentration of the adsorbates on the surface (Γ) and in solution (C) at different temperatures. The surface coverage data were obtained from the reductive desorption process RS-Au + e- �� RS- + Au°, where R = Hpyt or FeHpyt, observed at -555 and -566 mV vs Ag|AgCl|Cl- for Hpyt and FeHpyt SAM, respectively, indicating an enhancement of the Au–S bond as consequence of the π-backbonding interaction from iron metal center toward the Hpyt moiety. The heterogeneous electron transfer reaction of cytochrome c metalloprotein was successfully assessed by Hpyt and FeHpyt and SAM, presenting a quasi-reversible voltammograms with potentials consistent with the native form of the protein.
As espécies 5-(4-piridil)-1,3,4-oxadiazol-2-tiol (Hpyt) e [Fe(CN)5Hpyt]3- (FeHpyt) adsorvem espontaneamente sobre ouro formando monocamadas automontadas (SAM - "Self-Assembled Monolayers") das quais, de acordo com os dados eletroquímicos, apresentam defeitos ou nanoporos por onde as moléculas de prova [Fe(CN)6]4– e [Ru(NH3)6]3+ acessam a superfície do eletrodo de ouro policristalino. A partir dessas moléculas de prova e da dependência entre a corrente faradáica e o pH do eletrólito, o pKa da monocamada de Hpyt foi calculada como 4,2. A partir dos resultados de microscopia de tunelamento STM (Scanning Tunneling Microscopy) obtidos para a monocamada automontada de Hpyt sobre Au(111) foi possível estimar que as moléculas de Hpyt são adsorvidas em um arranjo hexagonal com um espaçamento médio entre os átomo de enxofre de 5,5 Å. Essas imagens também mostraram a presença de nanoporos, do qual indica que fortes interações laterais não ocorrem efetivamente. Os parâmetros termodinâmicos ΔHads, ΔGads e ΔSads para o processo de adsorção das moléculas Hpyt e FeHpyt foram calculados a partir da correlação entre a concentração dos adsorbatos na superfície (Γ) e em solução (C) para diferentes temperaturas. A quantidade de moléculas adsorvidas foi calculada a partir do processo de desorção redutiva, onde R = Hpyt ou FeHpyt, observados em -555 e -566 mV versus Ag|AgCl|Cl- para as monocamadas de Hpyt e FeHpyt, respectivamente, indicando um fortalecimento da ligação Au–S como conseqüência do efeito π-backbonding do centro metálico ferro para o ligante Hpyt. A reação heterogênea de transferência de elétrons da metaloproteína citocromo c foi satisfatoriamente acessada pelas monocamadas de Hpyt e FeHpyt, apresentando um voltamograma quasi-reversível com potenciais consistentes com a forma nativa desta proteína.

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Riederer, Cordula. « Zur Synthese von Tetrahydro-oxazolo[4,3-c]-1,2,4-oxadiazol-5-onen und Tetrahydro-oxazolo[4,3-c]-1,2,4-oxadiazin-6-onen aus 4-Hydroxyimino-oxazolidin-2-onen ». [S.l. : s.n.], 1999. http://www.sub.uni-hamburg.de/disse/68/riederer.PDF.

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Le, Falher Laetitia. « Préparation et dérivatisation de 4H-pyrido[e][1,3]oxazinones : une contribution à la diversité chimique ». Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066344.

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Ce manuscrit porte sur la synthèse et les applications d'une nouvelle série de composés hétéroaromatiques : les 4H-pyrido[e][1,3]oxazin-4-ones. La première partie de ce manuscrit présente la préparation de ces squelettes via une réaction d'O-arylation intramoléculaire. La seconde partie du manuscrit repose sur la réactivité de ces entités chimiques et de leur utilisation en tant qu'intermédiaires de synthèse. La fonctionnalisation des 4H-pyrido[e][1,3]oxazin-4-ones, via des réactions de couplage pallado-catalysées, a permis d'obtenir des systèmes polyfonctionnalisés plus complexes. Les pyrido-oxazinones ont également été transformées, en une étape, en divers petits hétérocycles d'intérêt : les 1,3,5-triazines, les 1,2,4-triazoles et les 1,2,4-oxadiazoles. La dernière partie du manuscrit est consacrée à l'utilisation des molécules synthétisées comme potentielles sondes fluorescentes pour la détection de protéines oxydées
This work focused on the synthesis and applications of a novel series of heteroaromaticcompounds: the 4H-pyrido[e][1,3]oxazin-4-ones. The first part of this thesis presents thepreparation of these pyrido-oxazinones via an intramolecular O-arylation reaction. The secondpart of this work relies on the reactivity of these chemical entities and their use as buildingblocks. The functionalization of the 4H-pyrido[e][1,3]oxazin-4-ones has been studied viacross-coupling reactions to obtain more elaborated structures. The pyrido-oxazinones werealso converted, in one step, into other diverse small molecules of interest: 1,3,5-triazines,1,2,4-triazoles and 1,2,4-oxadiazoles. The last part of this thesis was devoted to the use of theobtained heterocycles as potential fluorescent probes for the detection of carbonylatedproteins

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Almeida, Leonardo Viana de. « Síntese e determinação da atividade antimicrobiana de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenil-substituído]-2,3-diidro-1,3,4-oxadiazol frente à cepa ATCC 25923 de Staphylococcus aureus ». Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-07042010-131506/.

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A introdução de um grupo substituinte na molécula de um fármaco promove alterações químico-estruturais que, por sua vez, modificam suas propriedades físicoquímicas. O arranjo espacial de átomos ou grupos de átomos, em especial grupos funcionais, na molécula de um fármaco, expressos por meio de suas propriedades físico-químicas, influenciam direta ou indiretamente na interação fármaco-receptor. Esta, por sua vez, determina aspectos farmacológicos e farmacocinéticos que influem na eficácia terapêutica do medicamento. Assim, uma série de compostos 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenil-substituído]-2,3-diidro-1,3,4-oxadiazolínicos foi planejada e os análogos foram sintetizados, identificados estruturalmente e avaliados in vitro quanto a atividade antimicrobiana frente a Staphylococcus aureus (cepa ATCC 25923), expressa pela determinação da concentração inibitória mínima. Cepas desta bactéria são comuns em infecções hospitalares e frequentemente apresentam caráter de multi-resistência, portanto, alternativas aos fármacos comumente empregados na terapia antibacteriana, especialmente em infecções multi-resitentes, são alvo de estudos e desenvolvimento. Relações entre mudanças estruturais de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4- fenil-substituído]-2,3-diidro-1,3,4-oxadiazolinas e suas respectivas concentrações inibitórias mínimas podem fornecer informações sobre a influência de propriedades físico-químicas na ação antibacteriana destes compostos, informações estas que podem contribuir para o entendimento das relações entre a estrutura química e a atividade biológica desta classe de compostos, visando a identificação qualitativa e quantitativa das propriedades físico-químicas que influenciam no perfil farmacológico desta classe de compostos. Os grupos substituintes introduzidos nos derivados de 2,3-diidro-1,3,4-oxadizolinas-2,3,5-substituídas contribuem para alterações em suas propriedades físico-químicas, sendo representadas por parâmetros físico-químicos que descrevem a natureza e intensidade da alteração observada. O presente trabalho objetivou identificar, partindo das propriedades físico-químicas, fatores da estrutura química que favoreçam a atividade antimicrobiana dos compostos estudados. A atividade antimicrobiana, expressa pela concentração inibitória mínima, foi determinada pelo procedimento de microdiluição sucessiva, no qual diferentes concentrações de composto a ser analisado foram incubadas em presença de inóculo de Staphylococcus aureus, em meio de cultura líquido. As microdiluições originam concentrações decrescentes a fim de se determinar a menor concentração do composto testado onde o crescimento microbiano foi inibido. Foram realizadas comparações entre as concentrações inibitórias mínimas dos compostos analisados e destas com parâmetros estruturais que representam as propriedades físico-químicas dos compostos. Baseado nas análises comparativas, identificou-se tendências que evidenciam a preponderância de propriedades físicoquímicas sobre a atividade antimicrobiana desempenhada. Constatou-se que a hidrofobicidade influi significativamente na atividade antimicrobiana. Observou-se também que o efeito eletrônico por indução e o volume do grupo substituinte em posição para-fenila também influenciam a ação antimicrobiana, mas estas ainda não foram conclusivas, carecendo de estudos mais aprofundados que levem à compreensão dos fatores estruturais que mais influenciam a ação antimicrobiana de 2-[5-nitro-tiofen-2-il]-3-acetil-5-[4-fenilsubstituído]- 2,3-diidro-1,3,4-oxadiazolinas, de forma a fundamentar o planejamento de futuros candidatos a fármacos antimicrobianos a partir desta classe de compostos.
The introduction of a substitute group within a drug molecule promotes chemical-structure shifts, which by consequence, alters its physical-chemical properties. The atomic special design, particularly the one related to functional groups, assumed in a drug molecule, expressed by the physical-chemical properties, interferers directly or indirectly on drug-receptor interaction. Theses effects collaborate to pharmacologic and pharmacokinetics aspects of drugs, interfering with its therapeutic efficient. Therefore, a set of 2-[5-nitro-thiophen-2-yl]-3-acetyl-5-[4- substitued-phenyl]-3,4-dihydro-1,3,4-oxadiazolines compounds was designed and its analogs synthesized, structurally identified, and in vitro assayed due to its antimicrobial activity against ATCC 25923 Staphylococcus aureus strains, through the determination of minimum inhibitory concentration. Strains of such bacterial species are commonly present within hospital infections, and frequently appear as multi-resistant variant. Consequently, alternatives to the agents usually applied in antimicrobial chemotherapy, particularly to multi-resistant infections, are target for drug research and development. Relations among structural shifts on 2-[5-nitro-thiophen-2-yl]-3-acetyl-5-[4-substitued-phenyl]-3,4-dihydro-1,3,4-oxadiazolines compounds and its respective minimum inhibitory concentration may lead to information about the influence of physical-chemical properties in antimicrobial activity. Continually, such information might contribute to the elucidation of chemical structure-biological activity relationship of these compounds. The substitutes groups inserted on 2,3,5-substituted-3,4-dihydro-1,3,4-oxadiazolines derivates contribute to differs the molecule physical-chemical properties, which is represented by its physical-chemical parameters, which describe the nature and intensity of the observed modification. Therefore, the following study aimed to identify, throughout physical-chemical properties, chemical structure factors that favor the antimicrobial activity of the synthesized compounds. The antibacterial activity, expressed as the minimum inhibitory concentration, was quantified by the microdilution method, where gradual concentrations of the tested conpound were incubated within ATCC 25923 Staphylococcus aureus cells suspended in broth medium. The microdilutions originated descending concentrations, in order to spot the minimum concentration whose microbial growth was inhibited. The minimum inhibitory concentration regarded to each compound was correlated to its physical-chemical parameters. Based on observed relations, it could be identified evidences assuming the physical-chemical properties relevance on antimicrobial assay. It was verified that hydrophobic effects interferes with antimicrobial activity, as well as inductive electronic effects and molecular volume of substitute group in para-phenyl position. These factors contribute to physical-chemical properties shifts and therefore play a role on the antimicrobial action. However, these latest two influences were enable to conclude, suggesting the need of more extensive studies. So that, a more profound comprehension about structure factors that interfere with 2,3,5-substitued-3,4-dihydro-1,3,4-oxadiazolines derivates might lead to the rational design of potential antimicrobial agents among this class of compounds.

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Wolf, Lucas. « Síntese de heterociclos : 2-alquil/arilcalcogeno-n-(4-aril-1,3-tiazol-2-il)acetamidas e (s)-n-(1-(3-aril-1,2,4-oxadiazol-5-il)alquil)-2-(calcogenofenil) acetamidas derivados de organocalcogênios ». Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4271.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
In the present work, a series of 2-alkyl/arylchalcogenide-N-(4-aryl-1,3-thiazol-2-yl)acetamide was prepared via addition of aryl or alkyl chalcogenides. This methodology allowed the preparation of new derivatives of 2-amino-1,3-thiazoles in good yields. The compound synthesized is intended to evaluate the biological potential from the antioxidant activity by scavenging capacity of the assay by ABTS and DPPH. Was also developed a methodology for obtaining the compounds (S)-N-(alkyl-1-(3-aryl-1,2,4-oxadiazol-5-yl)-2-(phenylchalcogenide)acetamide derived from (S)-2-(2-(phenylchalcogenide)acetamido)alkanoic acids and arylamidoximes employing microwave irradiation. This synthesis was carried out in three conditions by varying the reaction time, temperature and solvent. The reactions employing microwave irradiation exhibit advantages against reactions using conventional method. These compounds were characterized by 1H NMR, 13C NMR and techniques high resolution mass spectrometry.
No presente trabalho, uma série de 2-alquil/arilcalcogeno-N-(4-aril-1,3-tiazol-2-il)acetamidas foi preparada via adição de calcogenetos de alquila ou arila. Essa metodologia permitiu a obtenção de derivados de 2-amino-1,3-tiazois em bons rendimentos. A proposta dessa síntese tem a finalidade de avaliar o potencial biológico a partir da atividade antioxidante por meio da capacidade sequestradora dos compostos sintetizados através de ensaios de ABTS e DPPH. Também foi desenvolvido uma metodologia para a obtenção dos compostos (S)-N-(1-(3-aril-1,2,4-oxadiazol-5-il)alquil)-2-(calcogenofenil)acetamidas derivados de ácidos (S)-2-(2-(calcogenofenil)acetamido)alcanoicos e arilamidoximas, empregando irradiação de micro-ondas. Para essa síntese foram desenvolvidas três condições reacionais variando o tempo reacional, temperatura e solvente. As reações conduzidas em micro-ondas apresentaram vantagens frente às reações em método convencional. Estes compostos foram caracterizados por técnicas de RMN 1H, RMN 13C e por espectrometria de massas de alta resolução.

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Pisarenko, Irina [Verfasser], et Joachim Kurt [Akademischer Betreuer] Fandrey. « Interaktionsanalyse der Hypoxie-induzierbaren Transkriptionsfaktoren HIF-2α und ARNT unter Berücksichtigung der Einflussnahme durch den HIF-2α-Liganden N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine und verschiedener HIF-2α-Mutationen / Irina Pisarenko ; Betreuer : Joachim Kurt Fandrey ». Duisburg, 2018. http://d-nb.info/1159879133/34.

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Singh, Neeraj. « Generation of 4,5-Dihydro-1,2,3-oxadiazole and Study of the Decomposition Products ». Doctoral thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-191706.

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4,5-Dihydro-1,2,3-oxadiazoles are postulated to be key intermediates in the synthesis of ketones from alkenes on an industrial scale, alkylation of DNA in vivo, decomposition of N-nitrosoureas (potent carcinogens), and are also a subject of great interest for theoretical chemists. In this thesis, formation of the parent compound and decay into secondary products has been studied by NMR monitoring analysis. The elusive properties and the intermediacy of the parent compound, 4,5-dihydro-1,2,3-oxadiazole, in the decomposition of suitably substituted N-nitrosoureas using Tl(I) alkoxides as bases, have been confirmed by the characterisation of its decay products viz., ethylene oxide, acetaldehyde, and especially diazomethane, at very low temperatures by 1H NMR, 13C NMR, 15N NMR, and relevant 2D NMR methods. Moreover, it has been shown that the methylation of nucleophilic molecules by 3-methyl-4,5-dihydro-1,2,3-oxadiazolium salts, which are considered to be activated forms of β−hydroxyalkylnitrosamines, does not involve 4,5-dihydro-1,2,3-oxadiazole as an intermediate, as has been reported in literature; instead, nucleophilic substitution leading to synthesis of open-chain products dominates the reaction
4,5-Dihydro-1,2,3-oxadiazole wurden als Schlüsselintermediate in der industriellen Synthese von Ketonen aus Alkenen, der in vivo Alkylierung von DNA und der Zersetzung von N-Nitrosoharnstoffen (potente Karzinogene) postuliert. Sie sind ebenso von großem Interesse in der theoretischen Chemie. Im Rahmen dieser Arbeit wurde die Bildung der Stammverbindung und deren Zersetzung in sekundäre Produkte mittels NMR-Verfolgung studiert. Die ausgesprochene Kurzlebigkeit der Stammverbindung 4,5-Dihydro-1,2,3-oxadiazol wurde durch die Charakterisierung der Produkte bei der Zersetzung geeignet substituierter N-Nitrosoharnstoffe mit Tl(I)-Alkoxiden bestätigt. Die Zersetzungsprodukte Ethylenoxid, Acetaldehyd und besonders Diazomethan wurden bei sehr niedrigen Temperaturen mittels 1H-NMR, 13C-NMR, 15N-NMR und relevanten 2D-NMR-Methoden charakterisiert. Des Weiteren konnte gezeigt werden, dass die Methylierung nucleophiler Spezies mit 3-Methyl-4,5-dihydro-1,2,3-oxadiazoliumsalzen, welchen als aktivierte Äquivalente der β−Hydroxyalkylnitrosamine verstanden werden, nicht zur Bildung von 4,5-Dihydro-1,2,3-oxadiazol als Intermediat führt, so wie dies in der Literatur berichtet wurde. Stattdessen wird die Bildung offenkettiger Produkte durch nukleophile Substitution bevorzugt

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Chen, Hui-shan, et 陳慧珊. « Calamitic Mesogens Formed by Heterocyclic Isoxazole, Benzoxazole and 1, 3, 4-Oxadiazole ». Thesis, 2015. http://ndltd.ncl.edu.tw/handle/8rc2n9.

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碩士
國立中央大學
化學學系
103
In the first series, a new system of isoxazole containing function group of aldehyde, performed reaction of Schiff Base then exhibition mesomorphic properties was synthesize and examined. 2b exhibited SmC phase. The control group 2a with N、SmC phase and 2c exhibited SmC phase. Results indicated that increasing the rigid cores would raise the isotropic temperatures and increasing the OH functional group would supply hydrogen bonds for molecular arrangement regularity. Using variable temperature IR spectroscopy observed the change of interaction. 1b、1c performed reaction of cyclization exhibited N, SmC and/or SmA phase. 1d was extended from 1b, and exhibited N phase. Two single crystallographic structures(1b、1d) were determined by X-ray crystallographic analysis. These mesomorphic properties were studied and identified by polarization microscopy, differential scanning calorimetry, and X-ray diffraction methods. In the second series, we succeed to synthesize three heterocyclic symmetric structure, 1e, characterization and their mesomorphic properties investigated. One single crystallographic structures were determined by X-ray crystallographic analysis. Compare with other similar example, results indicated that isoxazole effected upon the molecular arrangement more than 1, 3, 4-oxadiazole but mesomorphic properties were no difference.

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Livres sur le sujet "4-oxadiazoly"

Rakaric, Peter. Oligo - 1, 3, 4 - oxadiazoles. Sudbury, Ont : Laurentian University, 1998.

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Tremblay, Rose-Marie. Synthesis of 5-methyl-1, 3, 4-oxadiazol-2-carboxylate esters. Sudbury, Ont : Laurentian University, 1994.

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Bradley, Jean-Claude. A study of the reactivity of the carboxyl function in 1, 3, 4-oxadiazole-2-carboxylates. Sudbury, Ont : Laurentian University, 1989.

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Chapitres de livres sur le sujet "4-oxadiazoly"

Ambhore, Ajay N. « An Efficient Green Synthesis of Diphenyl Pyrazol-4-Yl-Thiopyridin-4-Yl-1,3,4-Oxadiazole Derivatives and Evaluation of Their Antimicrobial and Antioxidant Activity ». Dans Modern Green Chemistry and Heterocyclic Compounds, 79–111. Series statement : Innovations in physical chemistry : monographic series : Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367276942-3.

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Khalid, Hira, Aziz-ur-Rehman, M. Athar Abbasi, Rashad Hussain, Abdul Malik, Muhammad Ashraf et M. Qaiser Fatmi. « Synthesis, Spectral Analysis and Biological Evaluation of 5-Substituted 1,3,4-Oxadiazole-2-yl-4-(Piperidin-1-ylsulfonyl)Benzyl Sulfide ». Dans Emerging Trends in Chemical Sciences, 221–38. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60408-4_14.

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Revanasiddappa, B. C., et E. V. S. Subrahmanyam. « Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents ». Dans New Innovations in Chemistry and Biochemistry Vol. 2, 124–29. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/nicb/v2/13095d.

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Actes de conférences sur le sujet "4-oxadiazoly"

Troitskaya-Markova, Nadezhda, Olga Vlasova et Oleg Rakitin. « 4,5-DIOXO-4,5-DIHYDRO-4Λ4,5Λ4-BIS([1,2,5]OXADIAZOLO)[3,4-с:3',4'-e]PYRIDAZINE AS A SYNTHETIC EQUIVALENT OF 4,4'-DINITROSO-3,3'-BI(1,2,5-OXADIAZOLE) ». Dans Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m779.aks-2019/305-307.

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Forostyanko, Anna, Elena Vasileva et Irina Proskurina. « SYNTHESIS OF 5-(4’-NITROPHENYL)-3-ARYL-1,2,4-OXADIAZOLES ». Dans Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m758.aks-2019/222-226.

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Stadlbauer, Wolfgang, Corinna Gressl, A. Elisabeth Täubl et Werner Fiala. « Cyclization of 4-Azido-3-nitroquinolines to Oxadiazolo[3,4-c]quinolines ». Dans The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland : MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00487.

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Malavolta, Juliana L., Alex F. C. Flores, Rayane B. Goularte, Alynne A. Souto et Morgana Doneda. « Synthesis of new biheterocyclic 4-(2-(1,3,4-oxadiazol-2- yl)ethyl)-6-(trifluoromethyl)pyrimidines ». Dans 14th Brazilian Meeting on Organic Synthesis. São Paulo : Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0107-1.

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Zhang, Wei, Junsheng Yu, Nana Wang, Chunhua Huang et Yadong Jiang. « Efficient organic photovoltaic cells using 2-(4-biphenylyl)-5-phenyl-1,3,4-oxadiazole as an exciton blocking layer ». Dans 5th International Symposium on Advanced Optical Manufacturing and Testing Technologies, sous la direction de Ya-Dong Jiang, Bernard Kippelen et Junsheng Yu. SPIE, 2010. http://dx.doi.org/10.1117/12.866815.

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Szafrański, Krzysztof, Jarosław Sławiński et Anna Kawiak. « Optimization of 4-chloro-5-[5-(2-arylvinyl)-1,3,4-oxadiazol-2-yl]benzenesulfonamide structure towards anticancer activity ». Dans 5th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland : MDPI, 2019. http://dx.doi.org/10.3390/ecmc2019-06318.

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Abood, Zeid Hassan, Hayder Raheem Ali et Hussein Ali Qabel. « Microwave synthesis of 2,3,5-trisubstituted-1,3-imidazolidin-4-ones bearing 1,3,4-oxadiazole moiety and preliminary evaluation of their antibacterial activity ». Dans THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5123064.

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Sushma et S. Ananda. « Synthesis of hybrid nano CoO/2-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-1,3,4-Oxadiazole : Characterization and its application for viscosity studies for lubrication and photo-degradation ». Dans DAE SOLID STATE PHYSICS SYMPOSIUM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0017530.

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saki, zeinab, Ali Kakanejadifard, Abedin Zabardasti, Farideh Azarbani et Sahar Kakanejadifard. « Synthesis, characterization, solvatochromic, antioxidant and antibacterial activities investigation of 2,2'-((1E,1'E)-((1,2,5-oxadiazole-3,4-diyl)bis (azanylylidene))bis(methanylylidene))bis(4-(phenyldiazenyl)phenol) ». Dans The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland : MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a047.

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Saleh, R. A., H. A. Mohammad, T. I. Gerber et E. C. Hosten. « Synthesis and characterization of mono and mixed ligand, Ni(II), Pd(II) and Pt(II) complexes of S-5-phenyl-1, 3, 4-oxadiazole-2-yl benzothioate with some tertiary diphosphines ligands ». Dans 6TH INTERNATIONAL CONFERENCE AND WORKSHOPS ON BASIC AND APPLIED SCIENCES. Author(s), 2017. http://dx.doi.org/10.1063/1.5004324.

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Rapports d'organisations sur le sujet "4-oxadiazoly"

Byrd, Edward F., et Jesse J. Sabatini. Theoretical Prediction of the Heats of Formation, Densities and Relative Sensitivities, and/or Synthetic Approaches Toward the Synthesis of High Energy Dense Materials (HEDMs) : 3,5-Dinitro-1,3,5-Oxadiazinane, Bis-Adjacent RDX, Bis-Adjacent HMX, 4,4',6,6'-Tetranitro-1,1'-Bis(N-oxide)-5,5',6,6'-4H,4'H-5,5'-Bisimidazo Oxadiazole, and the Open-Cage Derivative of CL-20. Fort Belvoir, VA : Defense Technical Information Center, août 2015. http://dx.doi.org/10.21236/ada626921.

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