Articles de revues : « 359.4/09/032 »

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Gilbertson, Robert L., et Meredith Blackwell. « George Baker Cummins 1904–2007 ». Mycologia 101, n^o 5 (septembre 2009) : 745–49. http://dx.doi.org/10.3852/09-032.

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Naughton, Corina, Marguerite de Foubert, Helen Cummins, Ruth McCullagh, Teresa Wills, Dawn A. Skelton, Darren Dahly et al. « Implementation of a Frailty Care Bundle (FCB) Targeting Mobilisation, Nutrition and Cognitive Engagement to Reduce Hospital Associated Decline in Older Orthopaedic Trauma Patients : Pretest-Posttest Intervention Study ». Journal of Frailty, Sarcopenia and Falls 9, n^o 1 (1 mars 2024) : 32–50. http://dx.doi.org/10.22540/jfsf-09-032.

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Zhu, Pingan, Chao Zhang et Jun Zou. « Digital image correlation for sensing kinematic fields in manufacturing processes : a review ». Journal of Intelligent Manufacturing and Special Equipment 2, n^o 2 (10 décembre 2021) : 37–62. http://dx.doi.org/10.1108/jimse-09-2021-032.

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PurposeThe purpose of the work is to provide a comprehensive review of the digital image correlation (DIC) technique for those who are interested in performing the DIC technique in the area of manufacturing.Design/methodology/approachNo methodology was used because the paper is a review article.Findingsno fundings.Originality/valueHerein, the historical development, main strengths and measurement setup of DIC are introduced. Subsequently, the basic principles of the DIC technique are outlined in detail. The analysis of measurement accuracy associated with experimental factors and correlation algorithms is discussed and some useful recommendations for reducing measurement errors are also offered. Then, the utilization of DIC in different manufacturing fields (e.g. cutting, welding, forming and additive manufacturing) is summarized. Finally, the current challenges and prospects of DIC in intelligent manufacturing are discussed.

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Wall, Tony. « Futures ». Journal of Work-Applied Management 11, n^o 2 (2 septembre 2019) : 102–5. http://dx.doi.org/10.1108/jwam-09-2019-032.

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Mygind, Niels, Joseph Blasi et Douglas Kruse. « Guest editorial : Introduction to special issue on overcoming the barriers for employee ownership part 1 ». Journal of Participation and Employee Ownership 6, n^o 2 (10 octobre 2023) : 97–100. http://dx.doi.org/10.1108/jpeo-09-2023-032.

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Ponomarev, Nikolaj Evgenevich, Dmitrij Mihajlovich Drozd, Tatyana Anatolevna Kamenskaya et Andrej Nikolaevich Shendrik. « ПОПЫТКА КОЛИЧЕСТВЕННОЙ ОЦЕНКИ ВКЛАДА ПАРАМЕТРОВ РАСТВОРИТЕЛЬ В ВЛИЯНИЕ НА СКОРОСТЬ РЕАКЦИЙ МОНОМОЛЕКУЛЯРНЫМ ГЕТЕРОЛИЗУ ». Научный взгляд в будущее, n^o 09-02 (30 avril 2018) : 88–92. http://dx.doi.org/10.30888/2415-7538.2018-09-02-032.

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. В роботі розглядається вплив параметрів розчинника, що впливають на швидкість реакцій мономолекулярного гетеролізу у розчинах та здійснено спробу кількісної оцінки вкладу параметрів розчинника (електрофільність, полярність) у прискорення реакцій

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Gu, Xiaojun, Sufen Tian, Dehui Wang, Gao Fei et Hui Wei. « Interaction between Short-Term Heat Pretreatment and Fipronil on 2ndInstar Larvae of Diamondback Moth,Plutella Xylostella(Linn) ». Dose-Response 8, n^o 3 (28 janvier 2010) : dose—response.0. http://dx.doi.org/10.2203/dose-response.09-032.gu.

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Agullo, Ivan, Béatrice Bonga et Patricia Ribes Metidieri. « Does inflation squeeze cosmological perturbations ? » Journal of Cosmology and Astroparticle Physics 2022, n^o 09 (1 septembre 2022) : 032. http://dx.doi.org/10.1088/1475-7516/2022/09/032.

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Abstract There seems to exist agreement about the fact that inflation squeezes the quantum state of cosmological perturbations and entangles modes with wavenumbers k⟶ and -k⟶. Paradoxically, this result has been used to justify both the classicality as well as the quantumness of the primordial perturbations at the end of inflation. We reexamine this question and point out that the definition of two-mode squeezing of the modes k⟶ and -k⟶ used in previous work rests on choices that are only justified for systems with time-independent Hamiltonians and finitely many degrees of freedom. We argue that for quantum fields propagating on generic time-dependent Friedmann-Lemaître-Robertson-Walker backgrounds, the notion of squeezed states is subject to ambiguities, which go hand in hand with the ambiguity in the definition of particles. In other words, we argue that the question “does the cosmic expansion squeeze and entangle modes with wavenumbers k⟶ and -k⟶?” contains the same ambiguity as the question “does the cosmic expansion create particles?”. When additional symmetries are present, like in the (quasi) de Sitter-like spacetimes used in inflationary models, one can resolve the ambiguities, and we find that the answer to the question in the title turns out to be in the negative. We further argue that this fact does not make the state of cosmological perturbations any less quantum, at least when deviations from Gaussianity can be neglected.

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Курляк, Петр, Владимир Костышин et Ярослав Бацала. « МОДЕЛИРОВАНИЕ ПРЕОБРАЗОВАТЕЛЕЙ ЭНЕРГИИ РАЗЛИЧНОЙ ФИЗИЧЕСКОЙ ПРИРОДЫ ». Modern engineering and innovative technologies, n^o 09-01 (29 octobre 2018) : 123–29. http://dx.doi.org/10.30890/2567-5273.2019-09-01-032.

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В статті розглянуто методологію моделювання перетворювачів енергії та описано основні постулати методу Bond Graph. Здійснено порівняння двох різнопланових аналогій між фізичними змінними систем різної фізичної природи та обґрунтовано доцільність застосува

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Annala, Jaakko, et Syksy Räsänen. « Inflation with R (αβ) terms in the Palatini formulation ». Journal of Cosmology and Astroparticle Physics 2021, n^o 09 (1 septembre 2021) : 032. http://dx.doi.org/10.1088/1475-7516/2021/09/032.

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Бэйке Ван. « COMPARATIVE ASPECTS OF INTERACTION OF DIFFERENT FORMS OF MUSICAL, THEATER AND CHOREOGRAPHY ART (on the example of the functioning of the National Academic Bolshoi Opera and Ballet Theater of Belarus ». Sworld-Us Conference proceedings, usc09-01 (30 janvier 2018) : 138–43. http://dx.doi.org/10.30888/2709-2267.2022-09-01-032.

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Олексенко, Светлана, et Елена Хоменко. « ПСИХОЛОГИЧЕСКОЕ ОБРАЗОВАНИЕ В УСЛОВИЯХ ДИСТАНЦИОННОГО ПОВЫШЕНИЯ КВАЛИФИКАЦИИ ». SWorldJournal, n^o 09-02 (30 septembre 2018) : 129–39. http://dx.doi.org/10.30888/2410-6615.2020-09-02-032.

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В статті розглядається проблема психологічної просвіти в процесі підвищення кваліфікації в дистанційному форматі, зокрема, доцільності впровадження навчальних модулів психологічного спрямування під час підвищення професійної компетентності в умовах диста

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Олексенко, Светлана, et Елена Хоменко. « ПСИХОЛОГИЧЕСКОЕ ОБРАЗОВАНИЕ В УСЛОВИЯХ ДИСТАНЦИОННОГО ПОВЫШЕНИЯ КВАЛИФИКАЦИИ ». SWorldJournal, n^o 09-02 (30 septembre 2018) : 129–39. http://dx.doi.org/10.30888/2663-5712.2021-09-02-032.

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В статті розглядається проблема психологічної просвіти в процесі підвищення кваліфікації в дистанційному форматі, зокрема, доцільності впровадження навчальних модулів психологічного спрямування під час підвищення професійної компетентності в умовах диста

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Graef, L. L., et R. Brandenberger. « A note on trans-Planckian tail effects ». Journal of Cosmology and Astroparticle Physics 2015, n^o 09 (9 septembre 2015) : 032. http://dx.doi.org/10.1088/1475-7516/2015/09/032.

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Eingorn, Maxim, Claus Kiefer et Alexander Zhuk. « Scalar and vector perturbations in a universe with discrete and continuous matter sources ». Journal of Cosmology and Astroparticle Physics 2016, n^o 09 (19 septembre 2016) : 032. http://dx.doi.org/10.1088/1475-7516/2016/09/032.

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Gondolo, Paolo, et Stefano Scopel. « Halo-independent determination of the unmodulated WIMP signal in DAMA : the isotropic case ». Journal of Cosmology and Astroparticle Physics 2017, n^o 09 (21 septembre 2017) : 032. http://dx.doi.org/10.1088/1475-7516/2017/09/032.

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Noorbala, Mahdiyar, Vincent Vennin, Hooshyar Assadullahi, Hassan Firouzjahi et David Wands. « Tunneling in stochastic inflation ». Journal of Cosmology and Astroparticle Physics 2018, n^o 09 (21 septembre 2018) : 032. http://dx.doi.org/10.1088/1475-7516/2018/09/032.

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Mas, Javier, Jonathan P. Shock et Javier Tarrío. « Holographic spectral functions in metallic AdS/CFT ». Journal of High Energy Physics 2009, n^o 09 (4 septembre 2009) : 032. http://dx.doi.org/10.1088/1126-6708/2009/09/032.

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Guo, Huai-Ke, Kuver Sinha et Chen Sun. « Probing boson stars with extreme mass ratio inspirals ». Journal of Cosmology and Astroparticle Physics 2019, n^o 09 (16 septembre 2019) : 032. http://dx.doi.org/10.1088/1475-7516/2019/09/032.

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Green, Daniel, et Enrico Pajer. « On the symmetries of cosmological perturbations ». Journal of Cosmology and Astroparticle Physics 2020, n^o 09 (15 septembre 2020) : 032. http://dx.doi.org/10.1088/1475-7516/2020/09/032.

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Roiban, Radu, et Anastasia Volovich. « Yang-Mills Correlation Functions from Integrable Spin Chains ». Journal of High Energy Physics 2004, n^o 09 (16 septembre 2004) : 032. http://dx.doi.org/10.1088/1126-6708/2004/09/032.

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Canoura, Felipe, Angel Paredes et Alfonso V. Ramallo. « Supersymmetric defects in the Maldacena-Núñez background ». Journal of High Energy Physics 2005, n^o 09 (12 septembre 2005) : 032. http://dx.doi.org/10.1088/1126-6708/2005/09/032.

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Herzog, Christopher P. « Energy loss of a heavy quark from asymptotically AdS geometries ». Journal of High Energy Physics 2006, n^o 09 (13 septembre 2006) : 032. http://dx.doi.org/10.1088/1126-6708/2006/09/032.

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Seiberg, Nathan, et Edward Witten. « String theory and noncommutative geometry ». Journal of High Energy Physics 1999, n^o 09 (30 septembre 1999) : 032. http://dx.doi.org/10.1088/1126-6708/1999/09/032.

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Imai, Shin'ichi, et Naoki Sasakura. « Scalar field theories in a Lorentz-invariant three-dimensional noncommutative space-time ». Journal of High Energy Physics 2000, n^o 09 (19 septembre 2000) : 032. http://dx.doi.org/10.1088/1126-6708/2000/09/032.

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Seto, Osamu, Kazunori Kohri et Takashi Nakamura. « Oscillating scalar-field dark matter in supergravity ». Journal of High Energy Physics 2001, n^o 09 (26 septembre 2001) : 032. http://dx.doi.org/10.1088/1126-6708/2001/09/032.

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Kikukawa, Yoshio, et Hiroshi Suzuki. « Chiral anomalies in the reduced model ». Journal of High Energy Physics 2002, n^o 09 (13 septembre 2002) : 032. http://dx.doi.org/10.1088/1126-6708/2002/09/032.

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Denk, Stefan, et Manfred Schweda. « Time ordered perturbation theory for non-local interactions ; applications to NCQFT ». Journal of High Energy Physics 2003, n^o 09 (15 septembre 2003) : 032. http://dx.doi.org/10.1088/1126-6708/2003/09/032.

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Essig, Rouven, Kuver Sinha et Gonzalo Torroba. « Meta-stable dynamical supersymmetry breaking near points of enhanced symmetry ». Journal of High Energy Physics 2007, n^o 09 (10 septembre 2007) : 032. http://dx.doi.org/10.1088/1126-6708/2007/09/032.

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Herranen, Matti, Kimmo Kainulainen et Pyry Matti Rahkila. « Quantum kinetic theory for fermions in temporally varying backrounds ». Journal of High Energy Physics 2008, n^o 09 (5 septembre 2008) : 032. http://dx.doi.org/10.1088/1126-6708/2008/09/032.

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Brax, Philippe, Carsten van de Bruck, Anne-Christine Davis et Jérôme Martin. « Decoupling dark energy from matter ». Journal of Cosmology and Astroparticle Physics 2009, n^o 09 (28 septembre 2009) : 032. http://dx.doi.org/10.1088/1475-7516/2009/09/032.

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Davis, Joshua L., Thomas S. Levi, Mark Van Raamsdonk et Kevin R. L. Whyte. « Twisted inflation ». Journal of Cosmology and Astroparticle Physics 2010, n^o 09 (29 septembre 2010) : 032. http://dx.doi.org/10.1088/1475-7516/2010/09/032.

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Lesgourgues, Julien, et Thomas Tram. « The Cosmic Linear Anisotropy Solving System (CLASS) IV : efficient implementation of non-cold relics ». Journal of Cosmology and Astroparticle Physics 2011, n^o 09 (27 septembre 2011) : 032. http://dx.doi.org/10.1088/1475-7516/2011/09/032.

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Tempel, Elmo, Andi Hektor et Martti Raidal. « Fermi 130 GeV gamma-ray excess and dark matter annihilation in sub-haloes and in the Galactic centre ». Journal of Cosmology and Astroparticle Physics 2012, n^o 09 (26 septembre 2012) : 032. http://dx.doi.org/10.1088/1475-7516/2012/09/032.

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Kobayashi, Takeshi, Ryosuke Kurematsu et Fuminobu Takahashi. « Isocurvature constraints and anharmonic effects on QCD axion dark matter ». Journal of Cosmology and Astroparticle Physics 2013, n^o 09 (25 septembre 2013) : 032. http://dx.doi.org/10.1088/1475-7516/2013/09/032.

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Lesgourgues, Julien, et Thomas Tram. « Fast and accurate CMB computations in non-flat FLRW universes ». Journal of Cosmology and Astroparticle Physics 2014, n^o 09 (17 septembre 2014) : 032. http://dx.doi.org/10.1088/1475-7516/2014/09/032.

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Kostyuk, Ivan, Robert Lilow et Matthias Bartelmann. « Baryon-photon interactions in Resummed Kinetic Field Theory ». Journal of Cosmology and Astroparticle Physics 2023, n^o 09 (1 septembre 2023) : 032. http://dx.doi.org/10.1088/1475-7516/2023/09/032.

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Abstract We explore how interactions between baryons and photons can be incorporated into Kinetic Field Theory (KFT), a description of cosmic structure formation based on classical Hamiltonian particle dynamics. In KFT, baryons are described as effective mesoscopic particles which represent fluid elements governed by the hydrodynamic equations. In this paper, we modify the mesoscopic particle model to include pressure effects exerted on baryonic matter through interactions with photons. As a proof of concept, we use this extended mesoscopic model to describe the tightly coupled baryon-photon fluid between matter-radiation equality and recombination. We show that this model can qualitatively reproduce the formation of baryon-acoustic oscillations in the cosmological power spectrum.

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Alter, Thomas D., Derrick M. Knapik, Floor Lambers, Martina Guidetti, Jorge Chahla, Philip Malloy et Shane J. Nho. « Sex-Based Differences in Femoroacetabular Impingement Syndrome and the Effect of Cam Deformity Location on the Extent of Labral Tearing : A 3-Dimensional Computed Tomography Study ». Orthopaedic Journal of Sports Medicine 10, n^o 5 (1 mai 2022) : 232596712210951. http://dx.doi.org/10.1177/23259671221095174.

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Background: Sex-specific quantification of cam morphology in patients with femoroacetabular impingement syndrome may improve diagnostics, surgical planning, and outcomes. Purpose: To (1) examine differences between men and women with symptomatic cam deformities based on deformity location, magnitude, and extent; (2) assess the association between cam deformity and labral pathology; and (3) evaluate the relationship between cam deformity and patient-reported outcome measures after hip arthroscopy. Study Design: Cohort study; Level of evidence, 3. Methods: Computed tomography (CT) scans were acquired in 98 consecutive patients before hip arthroscopy for femoroacetabular impingement syndrome. Custom software was used to generate 3-dimensional bone models and align them to a standard coordinate system. The alpha angle was measured at the 12-, 1-, 2-, and 3-o’clock positions, with 12 and 3 o’clock corresponding to the superior and anterior aspects of the femur, respectively. These alpha angle measurements were used to define the cam midpoint and extent. The labral tear midpoint and extent were evaluated intraoperatively. Bivariate correlation analysis was used to evaluate the association between the cam and labral tear midpoints and between the extent of the cam morphology and labral tearing. Results: The 3-dimensional models were analyzed in a cohort of 69 female and 29 male patients. Male patients were older (mean ± SD, 38.9 ± 12.6 vs 30.7 ± 12.2 years, P = .006) and had a greater body mass index (27.8 ± 4.4 vs 25.3 ± 5.6 kg/m2, P = .005). Male patients had greater alpha angle measures at 12, 1, and 3 o’clock ( P < .05) and a greater maximum alpha angle (69.0° ± 18.8° vs 62.1° ± 21.0°, P = .031); the location of their maximum cam impingement was also significantly different ( P < .05) when compared with female patients. Cam impingement (2:06 ± 1:09 vs 1:33 ± 1:16 clockfaces, P = .032) and labral tearing (3:02 ± 0:35 vs 2:34 ± 0:53 clockfaces, P = .003) in men extended over a greater region of the femoral clockface when compared with women. Significant correlations were demonstrated between the cam and labral tear midpoint locations ( r = 0.190, P = .032) and the extent of the cam deformity and labral tearing ( r = 0.203, P = .024). There were no sex-based differences in patient-reported outcome measures at baseline or 2-year follow-up. Conclusion: Male patients possessed greater cam deformity magnitude and extent when compared with female patients. Cam pathomorphology was associated with the location and extent of labral tearing.

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Vidyashankar, Satyakumar, Kari Sambaiah et Krishnapura Srinivasan. « Dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones in experimental mice ». British Journal of Nutrition 101, n^o 11 (5 novembre 2008) : 1621–29. http://dx.doi.org/10.1017/s0007114508118748.

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Mice fed with diet containing 0·5 % cholesterol for 10 weeks resulted in cholesterol supersaturation in gallbladder bile which promoted the formation of cholesterol gallstones (CGS). In this study, dietary hypocholesterolaemic spices, garlic and onion (both raw or heat-processed) were examined for their antilithogenic potential by including at 0·6 and 2·0 % level, respectively, along with lithogenic (LG) diet for 10 weeks. Dietary garlic and onion reduced the CGS incidence by 15–39 %, the effect being maximum in the heat-processed onion group. Dietary garlic and onion markedly reduced biliary cholesterol. The cholesterol:phospholipid ratio which was 1·58 in the LG diet group was reduced to 0·73–0·96 in the garlic and onion groups. The biliary cholesterol saturation index was 0·92, 1·25, 1·09 and 0·86, respectively, in the heat-processed onion, raw garlic, heat-processed garlic and raw onion groups, while it was 1·9 in the LG group. The hydrophobicity index of bile was − 0·08, − 0·079, − 0·032 and − 0·073, respectively, in the heat-processed onion, raw garlic, heat-processed garlic and raw onion groups, while it was +0·054 in the LG group. Hepatic hydroxymethyl glutaryl-CoA reductase activity was lowered in the LG diet-fed group, while dietary garlic or onion countered this alteration and also increased the activities of hepatic cholesterol 7α-hydroxylase and sterol 27-hydroxylase. Serum and liver cholesterol were decreased by feeding garlic or onion compared to the LG diet. Thus, dietaryAlliumspices exerted antilithogenic influence by decreasing the cholesterol hyper-secretion into bile and increasing the bile acid output thus decreasing the formation of lithogenic bile in experimental mice.

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Haroutonian, C., I. Johnston, T. Kao, A. McKinnon, A. Lam, A. Ricciardiello, A. D'Rozario et S. Naismith. « O005 Overnight consolidation of spatial navigation memories is impaired in Mild Cognitive Impairment and is associated with loss of sleep spindles and hippocampal subfield volumes ». SLEEP Advances 3, Supplement_1 (1 octobre 2022) : A2—A3. http://dx.doi.org/10.1093/sleepadvances/zpac029.004.

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Abstract Introduction Allocentric spatial navigation (SN) is considered a measure for conversion from mild cognitive impairment (MCI) to Alzheimer’s disease. NREM sleep slow waves and spindles, and hippocampal volume (HV) are impaired in MCI, however their relationship with SN overnight memory consolidation (OMC) is unknown. This study aimed to examine: 1) SN OMC in MCI, and, 2) associations between SN OMC and NREM oscillations and HV. Methods Cognitively-intact (n=25), non-amnestic MCI (naMCI, n=22) and amnestic-MCI (aMCI, n=10) older adults completed neuropsychological assessment, neuroimaging, overnight routine and high-density EEG polysomnography (hdEEG subset; controls=17, MCI=8). Slow oscillations, slow wave activity, slow and fast spindle density and power were computed. OMC% was calculated by: ([post-sleep error score/pre-sleep error score]*100) from a familiar and novel (allocentric) location. Right CA1, dentate gyrus (DG) and entorhinal cortex were computed using ASHS software. Results MCI performed worse on familiar location-OMC% compared to controls (Cohens d= -.67, p= .016). aMCI performed worse on allocentric-OMC% compared to controls (omega2= .09, p= .032). Reduced spindles were associated with worse allocentric-OMC% in aMCI (frontal-slow spindles [rho= -.782 p= .008], parietal-fast spindles [rho= -.576, p= .082]). Using hdEEG, widespread fast spindle and allocentric-OMC% associations were indicated in MCI. Reduced right HV (DG [r= -.453, p= .023], CA1 [r= -.426, p= .068]) was related to worse allocentric-OMC% in MCI. Discussion In MCI, SN OMC is impaired, with worse consolidation associated with spindle and right HV loss. Future studies should examine whether SN OMC and spindles capture conversion to Alzheimer’s disease in ‘at-risk’ older adults.

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Verberne, Suzan, Lou Boves, Nelleke Oostdijk et Peter-Arno Coppen. « What Is Not in the Bag of Words for Why-QA ? » Computational Linguistics 36, n^o 2 (juin 2010) : 229–45. http://dx.doi.org/10.1162/coli.09-032-r1-08-034.

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While developing an approach to why-QA, we extended a passage retrieval system that uses off-the-shelf retrieval technology with a re-ranking step incorporating structural information. We get significantly higher scores in terms of MRR@150 (from 0.25 to 0.34) and success@10. The 23% improvement that we reach in terms of MRR is comparable to the improvement reached on different QA tasks by other researchers in the field, although our re-ranking approach is based on relatively lightweight overlap measures incorporating syntactic constituents, cue words, and document structure.

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Яременко, Наталія. « ШЛЯХИ ПОДОЛАННЯ ОСВІТНІХ ВТРАТ У МОЛОДШИХ ШКОЛЯРІВ ». Педагогічні науки : теорія, історія, інноваційні технології 8-9, n^o 132-133 (23 novembre 2023) : 032–42. http://dx.doi.org/10.24139/2312-5993/2023.08-09/032-042.

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У статті автором проаналізовано стан освітніх втрат в Україні та запропоновано шляхи подолання освітніх втрат в учнів початкової школи. Серед можливих шляхів подолання освітніх втрат у молодших школярів окреслено систематичне та постійне визначення та закріплення необхідних навичок; підвищення інтересу та зацікавленість учнів; упровадження навчання через проєкти; персоналізація навчального досвіду; залучення членів родини та громадських організацій до процесу навчання; використання прийому позитивних дій та налагодження міжкласної співпраці

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Суркова, Ганна, Тетяна Плачинда et Наталія Долгополова. « ВПРОВАДЖЕННЯ ІННОВАЦІЙНИХ ПЕДАГОГІЧНИХ ТЕХНОЛОГІЙ У ПОЗАШКІЛЬНІЙ ОСВІТІ НА ПРИКЛАДІ КІРОВОГРАДСЬКОГО ОБЛАСНОГО ЦЕНТРУ ДИТЯЧОЇ ТА ЮНАЦЬКОЇ ТВОРЧОСТІ ». Педагогічні науки : теорія, історія, інноваційні технології 8-9, n^o 132-133 (23 novembre 2023) : 023–32. http://dx.doi.org/10.24139/2312-5993/2023.08-09/023-032.

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У статті порушено наукову проблему щодо необхідності впровадження в освітній процес позашкільних закладів освіти інноваційних педагогічних технологій. Розкрито застосування інноваційних педагогічних технологій у позашкільній освіті на прикладі Кіровоградського обласного центру дитячої та юнацької творчості. Висвітлено досвід роботи інноваційної педагогічної технології «Арт ‐ лабораторія життєвих завдань». Схарактеризовано етапи становлення інноваційної педагогічної технології й окреслено тематичні напрями зазначеної Арт – лабораторії. Описана робота з вихованцями за тематичними напрямами Арт – лабораторії життєвих завдань, зокрема мета, методи та форми організації занять. Більш детально розкрита форма роботи з вихованцями «Діамантове ранжування». Висновлено, що інноваційна педагогічна технологія, що розроблена та впроваджена педагогічним колективом Кіровоградського обласного ЦДЮТ сприяє формуванню у підростаючого покоління необхідних духовних, моральних і патріотичних цінностей.

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Cocciardi, Sibylle, Nina Weiß, Maral Saadati, Sabrina Skambraks, Daniela Weber, Isabelle Schneider, Annika Meid et al. « The Genomic Landscape and Its Clinical Implication in NPM1-Mutated AML Patients : A Study within the AMLSG 09-09 Clinical Trial ». Blood 142, Supplement 1 (28 novembre 2023) : 4311. http://dx.doi.org/10.1182/blood-2023-185566.

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Background: Mutations in the Nucleophosmin 1 gene ( NPM1 mut ) represent one of the most common genetic lesions in acute myeloid leukemia (AML).Based on its characteristic clinico-pathologic features, NPM1 mutAML has been recognized as a distinct entity among the category “AML with recurrent genetic abnormalities”. According to the ELN 2022 genetic risk-stratification, NPM1 mut AML, in the absence of FLT3-ITD mutation, is associated with a favorable prognosis. However, a significant proportion of these patients (pts) relapse after intensive therapy suggesting that other co-mutations may have an impact on outcome. Aims: To comprehensively characterize the genomic landscape and leukemogenic trajectoriesin a large cohort of NPM1 mut AML pts and to investigate its prognostic and predictive impact on outcome. Methods: Targeted DNA sequencing (mean read depth: 1817) on the entire coding region of 263 genes was performed in 568 NPM1 mut AML pts (median age: 58.7 years; 18-60 years, n=317; >60 years, n=251). All pts were enrolled in the randomized open-label Phase 3 AMLSG 09-09 trial [NCT00893399; Döhner H et al. Lancet Haematol 2023]. In this trial, pts were assigned to intensive chemotherapy plus all- trans retinoic acid with or without gemtuzumab ozogamicin; none of the pts received midostaurin. Results: In total n=3,058 variants (variant allele frequency of ≥1%) were identified in 195/263 genes. The median number of co-mutations was 3 (range 0-11). The most common co-mutated genes were DNMT3A (49.5%), FLT3-TKD (42.8%) PTPN11 (24.8%), NRAS (22.7%) TET2 (21.7%), IDH2 (21.3%), IDH1 (18%), and FLT3-ITD (17.3%). DNMT3AR882 hotspot mutations occurred more frequently in younger pts (36.6% vs 17.1%), while there was no difference for DNMT3AnonR882 mutations between the two age groups (21.8% and 21.9%). An age-dependent difference was also identified for mutations in myelodysplasia-related genes ( ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, and ZRSR2) as defined by the ICC, occurring with a higher incidence in older pts (30.3% vs 12.3% in younger pts). Analyzing the mutational pattern of co-mutations, we found statistically significant tertiary gene-gene interactions: e.g., NPM1- NFE2- STAG2 (p<.001), NPM1- IDH2- SRSF2 (p<.001), NPM1- CEBPA- TET2 (p<.001), NPM1- DNMT3AR882- NRAS (p=.002), and NPM1- ASXL1- SRSF2 (p=.004); mutual exclusivities were identified for NPM1- DNMT3AR882- DNMT3AnonR882 (p<.001), NPM1- IDH2- TET2 (p<.001), NPM1- DNMT3AR882- SRSF2 (p<.001), NPM1- IDH1- TET2 (p<.001), and NPM1- FLT3-ITD- KRAS (p<.002). Correlating co-mutation data with outcome, we found that DNMT3AR882 hotspot mutations confer inferior event-free (EFS) and overall survival (OS) only in younger pts (EFS, p<.001 vs p=.11, Figure 1a; OS, p=.003 vs p=.8), whereas DNMT3AnonR882 mutations did not impact prognosis within the two age groups. We also found a negative prognostic impact of IDH1 mutations which was restricted to younger pts (EFS, p=.05), whereas IDH2 mutations were associated with superior EFS in older pts (p=.04) and superior OS in both groups (p=.05 and p=.03). Of note, co-mutations occurring in one or more of the myelodysplasia-related genes did not impact EFS or OS (Figure 1b). In multivariable analysis (all pts) including age, WBC, LDH, allogeneic transplantation in CR1, and mutations with an incidence of at least 3% as covariables, age (HR,1.03; p<.001), DNMT3AR882 (HR, 1.86; p<.001), FLT3-ITD (HR, 1.54; p=.012), IDH1 (HR, 1.48; p=.009), MYC (HR, 1.83; p=.032), and WT1 (HR, 1.73; p=.012), were associated with an inferior EFS, while SMC3 mutation showed favorable EFS (HR, 0.44; p=.019). To further study the leukemogenic trajectories, we used an oncogenetic tree modeling algorithm, which yielded a tree with several main branches including DNMT3AR882, DNMT3AnonR882, FLT3-TKD , IDH1, IDH2, PTPN11, and TET2. These mutations might represent initiating events which predispose to additional events with further distinct branches. Conclusions: Our study provides comprehensive data on the genomic landscape and its clinical impact in pts with NPM1mut AML fit for intensive chemotherapy. The co-mutational pattern clearly differs between younger and older NPM1 mutAML pts. Using this large dataset allowed the identification of secondary and tertiary gene-gene interactions with significant impact on outcome. Further data analysis is ongoing and will be presented at the meeting.

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Chang, V. T., D. R. Hoover, J. Cogswell, M. Cholankeril, S. Badin, W. Yang, H. Yan, M. L. Gonzalez, J. Einhorn et B. S. Kasimis. « Comorbidity and survival in advanced non-small cell lung cancer (NSCLC) veteran patients ». Journal of Clinical Oncology 27, n^o 15_suppl (20 mai 2009) : e20675-e20675. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e20675.

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e20675 Background: Prognostic value of comorbidity at diagnosis has received increasing attention. We studied whether the Charlson Comorbidity Index (CMI), Cumulative Illness Rating Scale (CIRS), Kaplan Feinstein Index (KFI), and/or VA Comorbidity Scale (VA) independently predicted survival for NSCLC patients Methods: In an IRB approved protocol, the charts of 101 patients with Stage IIIA, IIIB or IV Non small cell lung cancer seen from 2004 through 2006 at a VA medical center were reviewed of whom 94 have already died. Comorbidity scores ECOG performance status (PS), stage, number of treatments, serum LDH, and albumin levels were obtained or coded from medical records. Survival analyses were performed using proportional hazards models. Results: Median (M) patient age was 69 years (range 51–88), the M ECOG PS was 1 (range 0–4); 13 (13%) had stage IIIA, 27 (26%) IIB and 62 (61%) IV. The M number of treatments was 1 (range 0–6). Histologies were adenocarcinoma in 48 (48%) pts, squamous cell in 37 (37%) pts, and other 17 (15%) pts. The M survival was 207 days (range 4–1785 days). The Median (and ranges) were: 4.2 (1.2–12.8) for CMI, 3 (0–6) for CIRS15, 5(0–11) for CIRS16, 1.8 (0–4) for CIRS17, 0(0–1) for CIRS18, 2 (0–3) for KFI, and 4 (0–8) for VA. The M albumin was 3.7 (range 1.9–5.3) and LDH 201 (range 104–1036). In univariate survival analyses, the stage (p<0.001), ECOG PS (p<0.001), albumin (p<0.003), and the CIRS 17 (p <0.052) were predictive of survival; when, however, bisected by median values, the VA scale (p<0.027), ECOG PS (p<0.052) and albumin (p<.0017) were significantly related to survival but age, LDH, CMI, KFI and subscales of the CIRS (CIRS 16, CIRS 17, CIRS18) were not related to survival. In multivariate proportional hazards analyses that included stage and a comorbidity index, the CIRS16 (p<.032) was an independent predictor of survival; the combinations of stage (p<0.008), ECOG PS (p<.004), stage (p<.006) and albumin (p<.002) were independent predictors of survival. Conclusions: In this small sample, current comorbidity indices did not add to determinations of survival of veterans with advanced NSCLC. Further research is needed in a larger sample. Supported in part by the New Jersey Commission for Cancer Research 09–1133-CCR-EO and VA HSRD IIR 02–103. No significant financial relationships to disclose.

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Rais, L., A. El Kettani, M. Zaki, G. Lahlou et A. Zaghloul. « 032 La cataracte congénitale unilatérale ». Journal Français d'Ophtalmologie 32 (avril 2009) : 1S26. http://dx.doi.org/10.1016/s0181-5512(09)73170-5.

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Gonçalves, RM, HB Lopes, BDR Lima, JMM Neto, RC Francisco, MC Bertolami, N. Ghorayeb, GS Dioguardi et DJ Daher. « L 032 Acute Variation of Lipid Profile in Marathon Runners after Competition ». Atherosclerosis Supplements 10, n^o 3 (août 2009) : 38. http://dx.doi.org/10.1016/s1567-5688(09)71798-2.

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Gallagher, A. M., F. De Vries, D. J. Nutt, J. Donoghue, A. T. Tylee, S. M. Cockle, T. P. van Staa et M. H. Lader. « P.2.a.032 Resource use in depressed patients with sleep disturbance ». European Neuropsychopharmacology 19 (septembre 2009) : S378—S379. http://dx.doi.org/10.1016/s0924-977x(09)70581-4.

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Soder, Rafael M., Guilherme Fortes Machado et Patrícia De Carli. « Os planos municipais de saúde como ferramenta de gestão e planejamento : um levantamento bibliométrico a respeito da produção acadêmica / Municipal health plans as a management and planning tool : a bibliometric survey about academic production ». Brazilian Journal of Health Review 5, n^o 4 (6 juillet 2022) : 12340–52. http://dx.doi.org/10.34119/bjhrv5n4-032.

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A revisão do estado da arte na área de Política, Planejamento e Gestão em Saúde (PPGS) é primordial para o desenvolvimento de estudos científicos, pois permite conhecer tendências, lacunas e desafios que se colocam para os pesquisadores, estudantes e gestores do sistema de saúde. O presente trabalho tem como objetivo delinear o perfil da produção científica a respeito dos Planos Municipais de saúde, considerando as dissertações e teses de doutorado. A pesquisa foi conduzida mediante a adoção da abordagem bibliométrica. A escolha da amostra está baseada em teses e dissertações. Nesse sentido, apropriou-se das publicações disponíveis no banco de teses do Portal de Periódicos da Capes/MEC. Na presente pesquisa foram analisados 10 trabalhos, sendo 09 dissertações e 01 tese de doutorado, houve concentração de trabalhos entre os anos de 2016 e 2020, a área de conhecimento ficou dividida entre Saúde Pública e Administração e planejamento em saúde, a metodologia mais utilizado foi a qualitativa, com análise documental e entrevistas semiestruturados, com abordagem metodológica em estudo de caso. Ficou evidente na pesquisa, o pouco envolvimento das universidades para pesquisar a respeito da temática.

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Boquoi, Amelie, Tina Chen et Greg H. Enders. « Chemoprevention of Mouse Intestinal Tumorigenesis by the Cyclin-Dependent Kinase Inhibitor SNS-032 ». Cancer Prevention Research 2, n^o 9 (septembre 2009) : 800–806. http://dx.doi.org/10.1158/1940-6207.capr-09-0053.

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